JPH0429680B2 - - Google Patents

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Publication number
JPH0429680B2
JPH0429680B2 JP58044509A JP4450983A JPH0429680B2 JP H0429680 B2 JPH0429680 B2 JP H0429680B2 JP 58044509 A JP58044509 A JP 58044509A JP 4450983 A JP4450983 A JP 4450983A JP H0429680 B2 JPH0429680 B2 JP H0429680B2
Authority
JP
Japan
Prior art keywords
blood coagulation
factor
polyethylene glycol
molecular weight
coagulation factor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP58044509A
Other languages
English (en)
Japanese (ja)
Other versions
JPS59172425A (ja
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Priority to JP58044509A priority Critical patent/JPS59172425A/ja
Publication of JPS59172425A publication Critical patent/JPS59172425A/ja
Publication of JPH0429680B2 publication Critical patent/JPH0429680B2/ja
Granted legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP58044509A 1983-03-18 1983-03-18 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤 Granted JPS59172425A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP58044509A JPS59172425A (ja) 1983-03-18 1983-03-18 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP58044509A JPS59172425A (ja) 1983-03-18 1983-03-18 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤

Publications (2)

Publication Number Publication Date
JPS59172425A JPS59172425A (ja) 1984-09-29
JPH0429680B2 true JPH0429680B2 (de) 1992-05-19

Family

ID=12693520

Family Applications (1)

Application Number Title Priority Date Filing Date
JP58044509A Granted JPS59172425A (ja) 1983-03-18 1983-03-18 新規な血液凝固因子誘導体およびその製造法ならびにそれを含有する血液凝固促進剤

Country Status (1)

Country Link
JP (1) JPS59172425A (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9503380D0 (sv) * 1995-09-29 1995-09-29 Pharmacia Ab Protein derivatives
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
LT1596887T (lt) 2003-02-26 2022-04-25 Nektar Therapeutics Polimero-faktoriaus viii fragmento konjugatai
SG155777A1 (en) 2003-04-09 2009-10-29 Neose Technologies Inc Glycopegylation methods and proteins/peptides produced by the methods
US9005625B2 (en) 2003-07-25 2015-04-14 Novo Nordisk A/S Antibody toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
CA2549413A1 (en) * 2003-12-03 2005-06-23 Neose Technologies, Inc. Glycopegylated factor ix
KR101100059B1 (ko) * 2004-06-30 2011-12-29 넥타르 테라퓨틱스 중합체­인자 ｉｘ 부분의 접합체
AU2014280936B2 (en) * 2004-06-30 2016-12-15 Nektar Therapeutics Polymer-factor ix moiety conjugates
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
PL2586456T3 (pl) 2004-10-29 2016-07-29 Ratiopharm Gmbh Remodeling i glikopegilacja czynnika wzrostu fibroblastów (FGF)
MX350293B (es) * 2004-11-12 2017-09-04 Bayer Healthcare Llc Modificacion dirigida al sitio del factor viii.
DK1835938T3 (da) * 2004-12-27 2013-11-04 Baxter Int Polymer-von Willebrand-faktor-konjugater
US9029331B2 (en) 2005-01-10 2015-05-12 Novo Nordisk A/S Glycopegylated granulocyte colony stimulating factor
EP1871795A4 (de) 2005-04-08 2010-03-31 Biogenerix Ag Zusammensetzungen und verfahren zur herstellung von glycosylierungsmutanten eines proteaseresistenten menschlichen wachstumshormons
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007056191A2 (en) 2005-11-03 2007-05-18 Neose Technologies, Inc. Nucleotide sugar purification using membranes
US20080248959A1 (en) 2006-07-21 2008-10-09 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
JP2010505874A (ja) 2006-10-03 2010-02-25 ノヴォ ノルディスク アー／エス ポリペプチドコンジュゲートの精製方法
BRPI0809670A8 (pt) 2007-04-03 2018-12-18 Biogenerix Ag métodos para aumentar a produção de célula tronco, para aumentar o número de granulócitos em um indivíduo, para prevenir, tratar e aliviar a mielossupressão que resulta de uma terapia contra o câncer, para tratar uma condição em um indivíduo, para tratar neutropenia e trombocitopenia em um mamífero, para expandir células tronco hematopoiéticas em cultura, para aumentar a hematopoiese em um indivíduo, para aumentar o número de célulars progenitoras hematopoiéticas em um indivíduo, e para fornecer enxerto estável da medula óssea, e, forma de dosagem oral.
MX2009013259A (es) 2007-06-12 2010-01-25 Novo Nordisk As Proceso mejorado para la produccion de azucares de nucleotidos.
ES2476690T3 (es) 2008-02-27 2014-07-15 Novo Nordisk A/S Moléculas conjugadas del Factor VIII

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5959629A (ja) * 1982-09-27 1984-04-05 Nippon Chem Res Kk 効力持続性組成物
JPS6042087A (ja) * 1983-08-19 1985-03-06 Nec Corp プリンタ

Also Published As

Publication number Publication date
JPS59172425A (ja) 1984-09-29

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