JPH0484900A - 変異誘発性および催奇形性を迅速にスクリーニングする検定法 - Google Patents

変異誘発性および催奇形性を迅速にスクリーニングする検定法

Info

Publication number: JPH0484900A
Authority: JP; Japan
Prior art keywords: reporter gene; gene; expression; product; sequence
Prior art date: 1988-11-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP1308838A

Other languages

English (en)

Japanese (ja)

Inventor

Cha-Mer Wei

チャーマー　ウェイ

Vermuri B Reddy

ヴァームリ　ビー．レディ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

rEVO Biologics Inc

Original Assignee

Transgenic Sciences Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-11-25

Filing date

1989-11-27

Publication date

1992-03-18

1989-11-27 Application filed by Transgenic Sciences Inc filed Critical Transgenic Sciences Inc

1992-03-18 Publication of JPH0484900A publication Critical patent/JPH0484900A/ja

Status Pending legal-status Critical Current

Links

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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0393—Animal model comprising a reporter system for screening tests

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Physics & Mathematics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Engineering & Computer Science (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Toxicology (AREA)
Tropical Medicine & Parasitology (AREA)
Cell Biology (AREA)
Plant Pathology (AREA)
Veterinary Medicine (AREA)
Food Science & Technology (AREA)
Medicinal Chemistry (AREA)
General Physics & Mathematics (AREA)
Pathology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

JP1308838A 1988-11-25 1989-11-27 変異誘発性および催奇形性を迅速にスクリーニングする検定法 Pending JPH0484900A (ja)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date
US27605588A	1988-11-25	1988-11-25
US276,055		1988-11-25
US43508589A	1989-11-13	1989-11-13
US435,085		1989-11-13

Publications (1)

Publication Number	Publication Date
JPH0484900A true JPH0484900A (ja)	1992-03-18

Family

ID=26957737

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1308838A Pending JPH0484900A (ja)	1988-11-25	1989-11-27	変異誘発性および催奇形性を迅速にスクリーニングする検定法

Country Status (3)

Country	Link
US (1)	US6100089A (fr)
EP (1)	EP0370813A3 (fr)
JP (1)	JPH0484900A (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH03502882A (ja) *	1987-12-15	1991-07-04	ザトラスティーズオブプリンストンユニヴァーシティ	変異原物質および発癌物質に関するトランスジェニック試験システム
FR2648149A1 (fr) *	1989-06-09	1990-12-14	Agronomique Inst Nat Rech	Souches modifiees de bacteries phytophathogenes et leurs applications pour le criblage de molecules utilisables pour la protection des cultures
JPH06506103A (ja) *	1990-04-05	1994-07-14	ストラタジーン	試験ｄｎａ配列を担持するトランスジェニック非ヒト動物を使用する変異誘発性試験
GB9100612D0 (en) *	1991-01-11	1991-02-27	Univ Edinburgh	Method of altering the metabolic state of non-dividing cells,transgenic animals and therapeutic agents
GB9103314D0 (en) *	1991-02-16	1991-04-03	Imp Cancer Res Tech	Assay systems
NL9100567A (nl) *	1991-04-02	1992-11-02	Ingeny Bv	Werkwijze voor het detecteren van mutaties, transgeen zoogdier, transgene zoogdiercel, en werkwijze voor het onderzoeken van stoffen of omstandigheden op mutagene eigenschappen.
EP0534640B1 (fr) *	1991-09-23	1996-10-02	Pfizer Inc.	Procédé pour détecter ARNm et ADN spécifiques dans les cellules
CA2130081A1 (fr) *	1992-02-14	1993-08-19	Jay M. Short	Test de mutagenese utilisant des animaux transgeniques non humanises portant des sequences d'adn temoin
AU3777693A (en) *	1992-02-27	1993-09-13	Ohio University	Mutagenicity testing using reporter genes with modified methylation frequencies
AU4220093A (en) *	1992-04-27	1993-11-29	Indiana University Foundation	Live animal mutagenesis systems for testing mutagenic agents in vivo
WO1993023533A1 (fr) *	1992-05-08	1993-11-25	Exemplar Corporation	Test in vivo de medicaments anti-neoplasiques
KR100300932B1 (ko) *	1992-07-06	2001-10-22	조이스 브린톤	리포터유전자에융합된세균의스트레스프로모터를이용하여독성을측정하는방법및진단키트
DE4306547C2 (de) *	1993-03-03	1996-07-11	Gsf Forschungszentrum Umwelt	In-vitro-Test zur Detektion von Proteinkinase C Inhibitoren
US6824976B1 (en) *	1993-04-02	2004-11-30	Rigel Pharmaceuticals, Inc.	Method for selective inactivation of viral replication
EP0649905B1 (fr) *	1993-10-22	1998-09-23	Kabushiki Kaisha Toyota Chuo Kenkyusho	Méthodes de détection des substances mutagènes utilisant un gène de luminescence
DE19502584C2 (de) *	1994-01-28	1999-08-12	Medigene Ag Ges Fuer Molekular	Verfahren zur Bestimmung der Aktivität eines regulatorischen Faktors sowie Verwendung dieses Verfahrens
DE19525285C2 (de) *	1995-06-28	1999-04-15	Inst Pflanzengenetik & Kultur	In vitro Testverfahren zum Nachweis Chemikalien-induzierter embryotoxischer/teratogener Effekte
FR2775694B1 (fr) *	1998-03-06	2000-06-09	Gradient Ass	Test de toxicite
US6673554B1 (en) *	1999-06-14	2004-01-06	Trellie Bioinformatics, Inc.	Protein localization assays for toxicity and antidotes thereto
EP1176211A1 (fr) *	2000-07-27	2002-01-30	Novartis Forschungsstiftung, c/o Novartis International AG	Procédé de surveillance des mutagenes dans les plantes
US6787321B1 (en)	2000-10-13	2004-09-07	The Regents Of The University Of California	Mammalian two-hybrid system for screening for modulators of the accumulation of metabolic products
US7723023B2 (en)	2001-08-14	2010-05-25	Mount Sinai School Of Medicine	Use of intrinsic reporters of cell signaling for high content drug profiling and toxicity screening

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US4873191A (en) *	1981-06-12	1989-10-10	Ohio University	Genetic transformation of zygotes
US4870009A (en) *	1982-11-22	1989-09-26	The Salk Institute For Biological Studies	Method of obtaining gene product through the generation of transgenic animals
US4792520A (en) *	1984-02-16	1988-12-20	University Of Cincinnati	Methods and kits for identifying mutagenic agents and molecular mutations in DNA in mammalian cells
US4569916A (en) *	1984-05-21	1986-02-11	Massachusetts Institute Of Technology	Assay for tumor promoting agents
US4753874A (en) *	1985-07-08	1988-06-28	Board Of Trustees Of The Leland Stanford Junior University	Rapid mutation testing system for human cells
DE3752347T2 (de) *	1986-05-20	2002-09-26	The General Hospital Corp., Boston	Verfahren zur pharmakokinetischen Studie der Insulin-Expression mit nicht-menschlichem Transgen-Säugetier
GB8615942D0 (en) *	1986-06-30	1986-08-06	Animal & Food Research Council	Peptide production
US5510099A (en) *	1987-05-01	1996-04-23	Stratagene	Mutagenesis testing using transgenic non-human animals carrying test DNA sequences
DE3854823T2 (de) *	1987-05-01	1996-05-23	Stratagene Inc	Mutagenesetest durch Verwendung von nicht menschlichen Lebewesen, die Test-DNS-Sequenzen enthalten
US4873316A (en) *	1987-06-23	1989-10-10	Biogen, Inc.	Isolation of exogenous recombinant proteins from the milk of transgenic mammals
JPH03502882A (ja) *	1987-12-15	1991-07-04	ザトラスティーズオブプリンストンユニヴァーシティ	変異原物質および発癌物質に関するトランスジェニック試験システム
WO1989009272A1 (fr) *	1988-03-22	1989-10-05	Chemical Industry Institute Of Toxicology	Souris transgenique pour la mesure et la caracterisation de mutations induites in vivo

1989
- 1989-11-23 EP EP19890312181 patent/EP0370813A3/fr not_active Withdrawn
- 1989-11-27 JP JP1308838A patent/JPH0484900A/ja active Pending
1993
- 1993-04-19 US US08/049,834 patent/US6100089A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP0370813A3 (fr)	1991-06-19
EP0370813A2 (fr)	1990-05-30
US6100089A (en)	2000-08-08

Publication	Publication Date	Title
JPH0484900A (ja)	1992-03-18	変異誘発性および催奇形性を迅速にスクリーニングする検定法
EP0289121B1 (fr)	1995-12-27	Test de mutagénèse utilisant des êtres non humains transgéniques porteurs des séquences d'ADN à essayer
Kress et al.	1990	Hox-2.3 upstream sequences mediate lacZ expression in intermediate mesoderm derivatives of transgenic mice
McKnight et al.	1983	Expression of the chicken transferrin gene in transgenic mice
Cohn et al.	1992	Use of transgenic mice to map cis-acting elements in the intestinal fatty acid binding protein gene (Fabpi) that control its cell lineage-specific and regional patterns of expression along the duodenal-colonic and crypt-villus axes of the gut epithelium.
Declercq et al.	2005	Salivary gland tumors in transgenic mice with targeted PLAG1 proto-oncogene overexpression
US20090202988A1 (en)	2009-08-13	Trap vectors and gene trapping using the same
JPH06503967A (ja)	1994-05-12	腫瘍感受性非ヒト動物
Mortensen et al.	1997	Selection of transfected mammalian cells
Boyd et al.	1993	Molecular biology of transgenic animals
Rose et al.	1994	A single element of the elastase I enhancer is sufficient to direct transcription selectively to the pancreas and gut
US20020013955A1 (en)	2002-01-31	Production of recombinant protein in transgenic fish
EP0579713B1 (fr)	1995-10-04	Procédé de détection de mutations dans l'ADN d'un mammifère transgénique ou d'une cellule de mammifère transgénique
US8476484B2 (en)	2013-07-02	Transgenic clawed frog embryos and use thereof as detectors of endocrine disrupters in the environment
JPH02145200A (ja)	1990-06-04	変異誘発性および催奇形性を迅速にスクリーニングする検定法
US5824287A (en)	1998-10-20	Mutagenesis testing using transgenic non-human animals carrying test DNA sequences
KR102133179B1 (ko)	2020-07-13	Irx1 유전자-녹아웃 형질전환 제브라피쉬 모델 및 이의 용도
EP1867716A1 (fr)	2007-12-19	Animal modelé dans lequel l'évolution d'un état pathologique peut être observée en temps réel, gène chimère utilise pour ce faire et utilisation correspondante
JP2001008577A (ja)	2001-01-16	生殖毒性化学物質のモニタリングに使用されるトランスジェニックマウス
WO1993024642A1 (fr)	1993-12-09	Insertion d'adn heterologue en dehors de genes chromosomiques connus
Hongo et al.	1991	Translational discrimination of ribosomal protein mRNAs in the early Drosophila embryo
WO1993017123A1 (fr)	1993-09-02	Test de la mutagenicite a l'aide de genes rapporteurs avec frequences de methylation modifiees
WO1993023533A1 (fr)	1993-11-25	Test in vivo de medicaments anti-neoplasiques
US7115796B2 (en)	2006-10-03	Transgenic pig containing heat shock protein 70 transgene
JP2001514848A (ja)	2001-09-18	生物的、物理的ならびに化学的な毒性因子の研究用トランスジェニック動物