JPH051026B2 - - Google Patents

Info

Publication number: JPH051026B2
Authority: JP; Japan
Prior art keywords: bone; chondroitin sulfate; hydroxyapatite; weight; aqueous solution
Prior art date: 1989-10-30
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP1279812A

Other languages

English (en)

Japanese (ja)

Other versions

JPH03141956A (ja

Inventor

Masahiro Hirano

Hiroyasu Takeuchi

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mitsubishi Materials Corp

Original Assignee

Mitsubishi Materials Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-30

Filing date

1989-10-30

Publication date

1993-01-07

1989-10-30 Application filed by Mitsubishi Materials Corp filed Critical Mitsubishi Materials Corp

1989-10-30 Priority to JP1279812A priority Critical patent/JPH03141956A/ja

1991-06-17 Publication of JPH03141956A publication Critical patent/JPH03141956A/ja

1993-01-07 Publication of JPH051026B2 publication Critical patent/JPH051026B2/ja

Status Granted legal-status Critical Current

Links

210000000988 bone and bone Anatomy 0.000 claims description 56
230000007547 defect Effects 0.000 claims description 25
239000000463 material Substances 0.000 claims description 23
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 claims description 20
SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 18
229920001287 Chondroitin sulfate Polymers 0.000 claims description 18
229940059329 chondroitin sulfate Drugs 0.000 claims description 18
239000000945 filler Substances 0.000 claims description 18
239000007864 aqueous solution Substances 0.000 claims description 17
239000012530 fluid Substances 0.000 claims description 14
229920003023 plastic Polymers 0.000 claims description 11
239000004033 plastic Substances 0.000 claims description 11
229910052588 hydroxylapatite Inorganic materials 0.000 description 13
XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 13
239000011800 void material Substances 0.000 description 13
KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 6
239000008187 granular material Substances 0.000 description 6
238000002156 mixing Methods 0.000 description 5
239000002245 particle Substances 0.000 description 5
238000001356 surgical procedure Methods 0.000 description 5
230000035876 healing Effects 0.000 description 4
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000000853 adhesive Substances 0.000 description 3
230000001070 adhesive effect Effects 0.000 description 3
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
TZCXTZWJZNENPQ-UHFFFAOYSA-L barium sulfate Chemical compound [Ba+2].[O-]S([O-])(=O)=O TZCXTZWJZNENPQ-UHFFFAOYSA-L 0.000 description 2
230000000694 effects Effects 0.000 description 2
OKJPEAGHQZHRQV-UHFFFAOYSA-N iodoform Chemical compound IC(I)I OKJPEAGHQZHRQV-UHFFFAOYSA-N 0.000 description 2
238000000034 method Methods 0.000 description 2
239000000843 powder Substances 0.000 description 2
150000003839 salts Chemical class 0.000 description 2
239000000126 substance Substances 0.000 description 2
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 1
208000006386 Bone Resorption Diseases 0.000 description 1
229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
235000002918 Fraxinus excelsior Nutrition 0.000 description 1
229920002683 Glycosaminoglycan Polymers 0.000 description 1
241001465754 Metazoa Species 0.000 description 1
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical group OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
229910052581 Si3N4 Inorganic materials 0.000 description 1
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000844 anti-bacterial effect Effects 0.000 description 1
239000002956 ash Substances 0.000 description 1
230000015572 biosynthetic process Effects 0.000 description 1
229940036348 bismuth carbonate Drugs 0.000 description 1
230000024279 bone resorption Effects 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
159000000007 calcium salts Chemical class 0.000 description 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
210000000845 cartilage Anatomy 0.000 description 1
239000000919 ceramic Substances 0.000 description 1
229960003260 chlorhexidine Drugs 0.000 description 1
238000005056 compaction Methods 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
239000002131 composite material Substances 0.000 description 1
239000002872 contrast media Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
GMZOPRQQINFLPQ-UHFFFAOYSA-H dibismuth;tricarbonate Chemical compound [Bi+3].[Bi+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GMZOPRQQINFLPQ-UHFFFAOYSA-H 0.000 description 1
235000011187 glycerol Nutrition 0.000 description 1
229920002674 hyaluronan Polymers 0.000 description 1
229960003160 hyaluronic acid Drugs 0.000 description 1
238000001027 hydrothermal synthesis Methods 0.000 description 1
239000007788 liquid Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000002504 physiological saline solution Substances 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
238000010298 pulverizing process Methods 0.000 description 1
HQVNEWCFYHHQES-UHFFFAOYSA-N silicon nitride Chemical compound N12[Si]34N5[Si]62N3[Si]51N64 HQVNEWCFYHHQES-UHFFFAOYSA-N 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
210000003954 umbilical cord Anatomy 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1

Landscapes

Dental Tools And Instruments Or Auxiliary Dental Instruments (AREA)
Materials For Medical Uses (AREA)
Dental Preparations (AREA)

JP1279812A 1989-10-30 1989-10-30 骨欠損部及び骨空隙部充填材 Granted JPH03141956A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP1279812A JPH03141956A (ja)	1989-10-30	1989-10-30	骨欠損部及び骨空隙部充填材

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP1279812A JPH03141956A (ja)	1989-10-30	1989-10-30	骨欠損部及び骨空隙部充填材

Publications (2)

Publication Number	Publication Date
JPH03141956A JPH03141956A (ja)	1991-06-17
JPH051026B2 true JPH051026B2 (fr)	1993-01-07

Family

ID=17616264

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP1279812A Granted JPH03141956A (ja)	1989-10-30	1989-10-30	骨欠損部及び骨空隙部充填材

Country Status (1)

Country	Link
JP (1)	JPH03141956A (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1676813A4 (fr) *	2003-08-22	2009-08-12	Nat Inst For Materials Science	Particule de phosphate de calcium spherique et poreuse partiellement substituee avec un ion metallique ou possedant un ion metallique sur sa surface, ainsi que particule de phosphate de calcium multicouche poreuse
WO2009099136A1 (fr) *	2008-02-07	2009-08-13	Kuraray Medical Inc.	Composition de phosphate de calcium et son procédé de fabrication

1989
- 1989-10-30 JP JP1279812A patent/JPH03141956A/ja active Granted

Also Published As

Publication number	Publication date
JPH03141956A (ja)	1991-06-17

Publication	Publication Date	Title
US5342441A (en)	1994-08-30	Biologically compatible hardening material for dental or medical applications
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CA2627537C (fr)	2014-10-21	Pate non durcissable pour reparation osseuse
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NZ537093A (en)	2006-01-27	Hydraulic cement based on calcium phosphate for surgical use
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Chen et al.	2017	Injectable calcium phosphate cements for hard tissue repair
Hablee et al.	2016	Recent developments on injectable calcium phosphate bone cement
JPH03174348A (ja)	1991-07-29	水硬性リン酸カルシウムセメント
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JP2007190169A (ja)	2007-08-02	リン酸カルシウム粉体組成物及びその製造方法
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