JPH05213947A - ７−アザイソインドリニル−キノロン−及びナフチリドンカルボン酸誘導体 - Google Patents

７−アザイソインドリニル−キノロン−及びナフチリドンカルボン酸誘導体

Info

Publication number
JPH05213947A
JPH05213947A JP4190249A JP19024992A JPH05213947A JP H05213947 A JPH05213947 A JP H05213947A JP 4190249 A JP4190249 A JP 4190249A JP 19024992 A JP19024992 A JP 19024992A JP H05213947 A JPH05213947 A JP H05213947A
Authority
JP
Japan
Prior art keywords
dihydro
carbon atoms
methyl
oxo
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4190249A
Other languages
English (en)
Japanese (ja)
Inventor
Uwe Petersen
ウベ・ペーターゼン
Andreas Krebs
アンドレアス・クレプス
Thomas Schenke
トーマス・シエンケ
Klaus Grohe
クラウス・グローエ
Klaus-Dieter Dr Bremm
クラウス−デイーター・ブレム
Rainer Endermann
ライナー・エンデルマン
Karl-Georg Metzger
カール−ゲオルク・メツツガー
Hans-Joachim Zeiler
ハンス−ヨアヒム・ツアイラー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of JPH05213947A publication Critical patent/JPH05213947A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/12—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
JP4190249A 1991-06-27 1992-06-25 ７−アザイソインドリニル−キノロン−及びナフチリドンカルボン酸誘導体 Pending JPH05213947A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4121214.2 1991-06-27
DE4121214A DE4121214A1 (de) 1991-06-27 1991-06-27 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate

Publications (1)

Publication Number Publication Date
JPH05213947A true JPH05213947A (ja) 1993-08-24

Family

ID=6434855

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4190249A Pending JPH05213947A (ja) 1991-06-27 1992-06-25 ７−アザイソインドリニル−キノロン−及びナフチリドンカルボン酸誘導体

Country Status (17)

Country Link
US (2) US5312823A (2)
EP (1) EP0520277A3 (2)
JP (1) JPH05213947A (2)
KR (1) KR930000514A (2)
CN (1) CN1068114A (2)
AU (2) AU647627B2 (2)
CA (1) CA2072207A1 (2)
CZ (1) CZ192892A3 (2)
DE (1) DE4121214A1 (2)
FI (1) FI922953A7 (2)
HU (1) HUT61545A (2)
IE (1) IE922099A1 (2)
IL (1) IL102288A0 (2)
MX (1) MX9203228A (2)
NO (1) NO922291L (2)
TW (1) TW209218B (2)
ZA (1) ZA924743B (2)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
AU4272793A (en) * 1993-04-24 1994-11-21 Korea Research Institute Of Chemical Technology Novel quinolone carboxylic acid derivatives and process for preparing the same
DE4339134A1 (de) * 1993-11-16 1995-05-18 Bayer Ag 1-(2-Fluorcyclopropyl)-chinolon- und -naphthyridoncarbonsäure-Derivate
KR950018003A (ko) * 1993-12-09 1995-07-22 스미스클라인 비참 피엘씨 신규한 퀴놀론 유도체 및 그의 제조 방법
DE4427530A1 (de) * 1994-08-04 1996-02-08 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE4435479A1 (de) * 1994-10-04 1996-04-11 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
DE19500792A1 (de) * 1995-01-13 1996-07-18 Bayer Ag Chinolon- und Naphthyridoncarbonsäure-Derivate
US6608081B2 (en) 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
CA2405532A1 (en) 2001-02-07 2002-08-22 Ortho-Mcneil Pharmaceutical, Inc. Pyridoarylphenyl oxazolidinone antibacterials, and related compositions and methods
EA019888B1 (ru) 2005-07-25 2014-07-30 Интермьюн, Инк. Промежуточное соединение для получения макроциклических ингибиторов репликации вируса гепатита с и способ его синтеза
FR2891274B1 (fr) * 2005-09-27 2007-11-23 Pierre Fabre Medicament Sa Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.
CN102443015A (zh) * 2010-10-13 2012-05-09 南京明生医药技术有限公司 一种7-取代喹啉羧酸衍生物及其制备方法和在抗菌抗结核上的应用
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
CN103351348A (zh) * 2013-07-15 2013-10-16 黄河三角洲京博化工研究院有限公司 一种2-甲胺基嘧啶盐酸盐的合成方法
HRP20180029T1 (hr) 2013-11-26 2018-02-09 F. Hoffmann - La Roche Ag Derivati oktahidro-ciklobuta[1,2-c;3,4-c']dipirola kao inhibitori autotaksina
PE20161372A1 (es) 2014-02-03 2017-01-08 Vitae Pharmaceuticals Inc Inhibidores de dihidropirrolopiridina de ror-gamma
KR20160128345A (ko) 2014-03-26 2016-11-07 에프. 호프만-라 로슈 아게 오토탁신(atx) 및 리소포스파티드산(lpa) 생성 억제제로서 이환형 화합물
WO2016046837A1 (en) * 2014-09-22 2016-03-31 Cadila Healthcare Limited An improved process for preparation of pyrrolo[3,4- c] pyrrole compounds and intermediates thereof
EA031967B1 (ru) 2014-10-14 2019-03-29 Вайтаи Фармасьютиклз, Инк. ДИГИДРОПИРРОЛОПИРИДИНОВЫЕ ИНГИБИТОРЫ ROR-γ
US9845308B2 (en) 2014-11-05 2017-12-19 Vitae Pharmaceuticals, Inc. Isoindoline inhibitors of ROR-gamma
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2016183741A1 (en) 2015-05-15 2016-11-24 Merck Sharp & Dohme Corp. Pyrimidinone amide compounds as pde2 inhibitors
WO2017024018A1 (en) 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
MX377277B (es) 2015-09-04 2025-03-07 Hoffmann La Roche Derivados de fenoximetilo.
AU2016328436B2 (en) * 2015-09-24 2020-05-14 F. Hoffmann-La Roche Ag New bicyclic compounds as dual ATX/CA inhibitors
KR20180053408A (ko) 2015-09-24 2018-05-21 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서의 신규한 이환형 화합물
EP3353180B1 (en) 2015-09-24 2022-03-16 F. Hoffmann-La Roche AG Bicyclic compounds as atx inhibitors
JP6914257B2 (ja) 2015-11-20 2021-08-04 ヴァイティー ファーマシューティカルズ，エルエルシー Ｒｏｒ−ガンマのモジュレーター
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
US9481674B1 (en) 2016-06-10 2016-11-01 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
CN110382484B (zh) 2017-03-16 2022-12-06 豪夫迈·罗氏有限公司 新的作为atx抑制剂的二环化合物
RU2019132254A (ru) 2017-03-16 2021-04-16 Ф. Хоффманн-Ля Рош Аг Гетероциклические соединения, пригодные в качестве дуальных ингибиторов atx/ca
MA45614B1 (fr) 2017-03-20 2020-04-30 Forma Therapeutics Inc Compositions de pyrrolopyrrole en tant qu'activateurs de la pyruvate kinase (pkr)
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
MX2020000887A (es) 2017-07-24 2020-07-22 Vitae Pharmaceuticals Llc Inhibidores de ror?.
CN113166060B (zh) 2018-09-19 2024-01-09 诺沃挪第克健康护理股份公司 用丙酮酸激酶激活化合物治疗镰状细胞病
EP3852791B1 (en) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activating pyruvate kinase r
CN109942488A (zh) * 2019-04-04 2019-06-28 山东省联合农药工业有限公司 一种喹啉羧酸酯类化合物及其制备方法与用途
CA3151612A1 (en) 2019-09-19 2021-03-25 George P. Luke Pyruvate kinase r (pkr) activating compositions
US12128035B2 (en) 2021-03-19 2024-10-29 Novo Nordisk Health Care Ag Activating pyruvate kinase R
CN113307768B (zh) * 2021-04-29 2023-12-12 中国农业科学院兰州畜牧与兽药研究所 喹诺酮类衍生物及其制备方法和用途
CN116941624B (zh) * 2021-04-29 2026-01-30 山东省联合农药工业有限公司 一种杀菌杀虫组合物及其应用

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5746986A (en) * 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
NZ208470A (en) * 1983-07-18 1988-06-30 Abbott Lab 6-fluoro-1,4-dihydro-4-oxo-quinoline-3-carboxylic acid derivatives and antibacterial compositions containing such
DE3577089D1 (de) * 1984-01-26 1990-05-17 Abbott Lab Antibakterielle chinolinderivate.
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
DE3420743A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-6,8-dihalogen-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
WO1989005643A1 (en) * 1987-12-18 1989-06-29 Pfizer Inc. Heterocyclic-substituted quinoline-carboxylic acids
JPH0262875A (ja) * 1988-05-23 1990-03-02 Wakunaga Pharmaceut Co Ltd 新規イソインドリン誘導体
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
KR910009333B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
KR910009330B1 (ko) * 1989-10-23 1991-11-11 재단법인 한국화학연구소 항균작용을 갖는 퀴놀린계 화합물과 그의 제조방법
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
DE4123918A1 (de) * 1991-07-19 1993-01-21 Bayer Ag 8-vinyl- und 8-ethinyl-chinoloncarbonsaeuren
WO1993013091A1 (fr) * 1991-12-27 1993-07-08 Wakunaga Seiyaku Kabushiki Kaisha Nouveau derive de quinolone ou sel de ce derive et agent antibacterien contenant ce derive
TW209865B (2) * 1992-01-10 1993-07-21 Bayer Ag

Also Published As

Publication number Publication date
FI922953A7 (fi) 1992-12-28
EP0520277A3 (en) 1993-01-13
CZ192892A3 (en) 1993-01-13
FI922953A0 (fi) 1992-06-25
HU9202145D0 (en) 1992-10-28
KR930000514A (ko) 1993-01-15
US5312823A (en) 1994-05-17
ZA924743B (en) 1993-03-31
AU1803092A (en) 1993-01-07
IL102288A0 (en) 1993-01-14
HUT61545A (en) 1993-01-28
CA2072207A1 (en) 1992-12-28
US5371090A (en) 1994-12-06
IE922099A1 (en) 1992-12-30
EP0520277A2 (de) 1992-12-30
AU647627B2 (en) 1994-03-24
NO922291D0 (no) 1992-06-11
TW209218B (2) 1993-07-11
NO922291L (no) 1992-12-28
DE4121214A1 (de) 1993-01-14
MX9203228A (es) 1992-12-01
AU5304094A (en) 1994-03-03
CN1068114A (zh) 1993-01-20

Similar Documents

Publication Publication Date Title
JPH05213947A (ja) ７−アザイソインドリニル−キノロン−及びナフチリドンカルボン酸誘導体
NZ243214A (en) 7-isoindolino-quinolone and naphthyridonecarboxylic acid derivatives and pharmaceutical compositions
JPH05271229A (ja) キノロン−およびナフチリドン−カルボン酸誘導体類
SK5394A3 (en) Quinolonecarboxilic acid naphtyridonecarboxilic acid derivatives
CZ288493B6 (en) Derivatives of 7-isoindolinylquinolone and 7-isoindolinylnaphthyridone, process of their preparation, intermediates for their preparation, their use as well as medicaments in which the derivatives are comprised
IE80557B1 (en) 8-vinyl- and 8-ethinyl-quinolone-carboxylic acids
KR100499366B1 (ko) 신규피리돈카르복실산유도체또는그염및그물질을유효성분으로하는항균제
KR100371883B1 (ko) 퀴놀론-및나프티리돈카르복실산유도체
US5621105A (en) Preparation of 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl) quinolonecarboxylic and 7-(aminomethyl-oxa-7-aza-bicyclo[3.3.0]oct-7-yl naphthyridonecarboxylic acid derivatives
US5753669A (en) Quinolone--and naphthyridonecarboxylic acid derivatives
SK137194A3 (en) 1-(2-fluorinecyclopropyl)-quinoline-carboxylic) and 1-(2- -florinecyclopropyl)-naphthyridonecarboxylic acid derivatives, method of their producing and their using in medicines
US5783708A (en) Intermediate compounds for the preparation of new quinolone-and naphthyridonecarboxylic acid derivatives
JPH08253480A (ja) １，６−ナフチリドンカルボン酸誘導体
NZ250005A (en) 4-amino-hexahydroisoindoles as process intermediates
JP2004115530A (ja) 新規ピリドンカルボン酸誘導体又はその塩並びに該物質を有効成分とする抗菌剤