JPH05214096A - 重合体化合物、ｎｍｒ診断およびｘ線診断のための薬剤の製造法、この種の薬剤、製薬学的薬剤、重合体化合物の製造法および製薬学的薬剤の製造法 - Google Patents

重合体化合物、ｎｍｒ診断およびｘ線診断のための薬剤の製造法、この種の薬剤、製薬学的薬剤、重合体化合物の製造法および製薬学的薬剤の製造法

Info

Publication number
JPH05214096A
JPH05214096A JP4114636A JP11463692A JPH05214096A JP H05214096 A JPH05214096 A JP H05214096A JP 4114636 A JP4114636 A JP 4114636A JP 11463692 A JP11463692 A JP 11463692A JP H05214096 A JPH05214096 A JP H05214096A
Authority
JP
Japan
Prior art keywords
groups
group
compound
mmol
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4114636A
Other languages
English (en)
Japanese (ja)
Inventor
Heribert Schmitt-Willich
シュミット−ヴィリッヒ ヘリベルト
Johannes Platzek
プラツェク ヨハネス
Heinz Gries
グリース ハインツ
Gabriele Schuhmann-Giampieri
シューマン−ギアムピエリ ガブリエレ
Thomas Dr Frenzel
フレンツェル トーマス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Publication of JPH05214096A publication Critical patent/JPH05214096A/ja
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyamides (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
JP4114636A 1991-05-10 1992-05-07 重合体化合物、ｎｍｒ診断およびｘ線診断のための薬剤の製造法、この種の薬剤、製薬学的薬剤、重合体化合物の製造法および製薬学的薬剤の製造法 Pending JPH05214096A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4115789A DE4115789A1 (de) 1991-05-10 1991-05-10 Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE4115789.3 1991-05-10

Publications (1)

Publication Number Publication Date
JPH05214096A true JPH05214096A (ja) 1993-08-24

Family

ID=6431673

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4114636A Pending JPH05214096A (ja) 1991-05-10 1992-05-07 重合体化合物、ｎｍｒ診断およびｘ線診断のための薬剤の製造法、この種の薬剤、製薬学的薬剤、重合体化合物の製造法および製薬学的薬剤の製造法

Country Status (15)

Country Link
US (1) US5876698A (de)
EP (1) EP0512661B1 (de)
JP (1) JPH05214096A (de)
AT (1) ATE162082T1 (de)
AU (1) AU661305B2 (de)
CA (1) CA2068266A1 (de)
DE (2) DE4115789A1 (de)
DK (1) DK0512661T3 (de)
ES (1) ES2113918T3 (de)
GR (1) GR3026249T3 (de)
IE (1) IE921504A1 (de)
IL (1) IL101817A (de)
NO (1) NO302951B1 (de)
NZ (1) NZ242683A (de)
ZA (1) ZA923394B (de)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09510239A (ja) * 1994-03-04 1997-10-14 ニコムド サルター，アイエヌシー． ポリキレート化剤
WO1998041241A1 (en) * 1997-03-18 1998-09-24 Nihon Schering K. K. Mri contrast media recognizing minor environmental changes
JP2018538294A (ja) * 2015-12-10 2018-12-27 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 造影剤
JP2019513782A (ja) * 2016-04-13 2019-05-30 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 造影剤

Families Citing this family (31)

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US5914095A (en) * 1989-04-07 1999-06-22 Salutar, Inc. Polychelants containg amide bonds
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
WO1994008630A1 (en) * 1992-10-13 1994-04-28 Mallinckrodt Medical, Inc. Novel compositions for magnetic resonance imaging
FI955575A7 (fi) * 1993-05-20 1996-01-15 Univ California Makromolekyylivarjoaine magneettiresonanssikuvaukseen
DE4317588C2 (de) * 1993-05-24 1998-04-16 Schering Ag Fluorhaltige makrocyclische Metallkomplexe, Verfahren zu ihrer Herstellung, sowie ihre Verwendung
DE4318369C1 (de) * 1993-05-28 1995-02-09 Schering Ag Verwendung von makrocyclischen Metallkomplexen als Temperatursonden
US5605672A (en) * 1993-06-09 1997-02-25 The General Hospital Corporation Blood pool imaging composition and method of its use
US5801228A (en) * 1995-06-07 1998-09-01 Nycomed Imaging As Polymeric contrast agents for medical imaging
US5756066A (en) * 1995-06-07 1998-05-26 Schering Aktiengesellschaft Iodine-containing peptides
FR2772025B1 (fr) * 1997-12-10 2000-03-03 Guerbet Sa Chelates metalliques de macrocycles polyaminocarboxyliques et leur application a l'imagerie par resonance magnetique
US6958148B1 (en) 1998-01-20 2005-10-25 Pericor Science, Inc. Linkage of agents to body tissue using microparticles and transglutaminase
US6919076B1 (en) 1998-01-20 2005-07-19 Pericor Science, Inc. Conjugates of agents and transglutaminase substrate linking molecules
US6342598B1 (en) 1998-11-26 2002-01-29 Bracco International B.V. Amphipatic polycarboxylic chelates and complexes with paramagnetic metals as MRI contrast agents
US20030050452A1 (en) * 2000-12-26 2003-03-13 Yuji Hashiguchi Process for producing metal complex of aminooligosaccharide derivative
US6549798B2 (en) * 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
DE10135355C1 (de) * 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
TWI221406B (en) * 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
US7648678B2 (en) * 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
EP2077290B1 (de) * 2005-12-05 2010-04-21 Nitto Denko Corporation Polyglutamat-Aminosäure-Konjugate und Verfahren
DE102007002726A1 (de) 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
US20080181852A1 (en) * 2007-01-29 2008-07-31 Nitto Denko Corporation Multi-functional Drug Carriers
JP2010526159A (ja) * 2007-04-10 2010-07-29 日東電工株式会社 多機能性ポリグルタミン酸塩薬物担体
ES2430380T3 (es) * 2007-05-09 2013-11-20 Nitto Denko Corporation Composiciones que incluyen un compuesto hidrófobo y un conjugado de poliaminoácido
WO2009111271A1 (en) * 2008-03-06 2009-09-11 Nitto Denko Corporation Polymer paclitaxel conjugates and methods for treating cancer
CA2909919C (fr) 2013-04-26 2022-07-12 Guerbet Formulation de produit de contraste et son procede de preparation associe
HUE060536T2 (hu) 2015-12-10 2023-03-28 Bracco Imaging Spa Dimer kontrasztanyagok
EP3551614B1 (de) 2016-12-12 2021-08-25 Bracco Imaging SpA Dimere kontrastmittel
WO2019018150A1 (en) 2017-07-17 2019-01-24 Ecolab USA, Inc. RHEOLOGY MODIFICATION AGENTS FOR SLURRY
MX2022014143A (es) * 2020-05-12 2022-11-30 Basf Se Uso de polimero carboximetilado de lisinas como agente dispersante y composiciones que comprenden el mismo.
CN114805800B (zh) * 2022-06-09 2023-03-07 大连理工大学 一种n-磺酰脒聚合物的制备方法及应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4385046A (en) * 1980-12-15 1983-05-24 Minnesota Mining And Manufacturing Company Diagnostic radio-labeled polysaccharide derivatives
US4423158A (en) * 1983-01-27 1983-12-27 Gelinnovation Handelsaktiebolag Ion adsorbent for metals having a coordination number greater than two
SE465907B (sv) * 1984-11-01 1991-11-18 Nyegaard & Co As Diagnosticeringsmedel innehaallande en paramagnetisk metall
DE3577185D1 (de) * 1984-11-01 1990-05-23 Nycomed As Paramagnetische kontrastmittel fuer die anwendung in "in vivo" nmr-diagnostischen methoden und die herstellung davon.
US4885363A (en) * 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
CA1266344A (en) * 1986-02-14 1990-02-27 Miki Kurami High molecular compounds having amino groups, and their utilization
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
DE3855239T2 (de) * 1987-07-16 1996-10-31 Nycomed Imaging As Aminocarbonsäure und Derivate
US5364613A (en) * 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
GB8916781D0 (en) * 1989-07-21 1989-09-06 Nycomed As Compositions
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
US5190744A (en) * 1990-03-09 1993-03-02 Salutar Methods for detecting blood perfusion variations by magnetic resonance imaging
GB9008724D0 (en) * 1990-04-18 1990-06-13 Celltech Ltd Chemical compounds
CA2039399C (en) * 1990-04-25 2000-09-05 C. Allen Chang Dual functioning excipient for metal chelate contrast agents
DE4035760A1 (de) * 1990-11-08 1992-05-14 Schering Ag Mono-n-substituierte 1,4,7,10-tetraazacyclododecan-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
JP2894879B2 (ja) * 1991-10-04 1999-05-24 日本メジフィジックス株式会社 診断用造影剤

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH09510239A (ja) * 1994-03-04 1997-10-14 ニコムド サルター，アイエヌシー． ポリキレート化剤
WO1998041241A1 (en) * 1997-03-18 1998-09-24 Nihon Schering K. K. Mri contrast media recognizing minor environmental changes
US6372194B1 (en) 1997-03-18 2002-04-16 Toshihiro Akaike MRI contrast media recognizing minor environmental changes
JP2018538294A (ja) * 2015-12-10 2018-12-27 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 造影剤
JP2019513782A (ja) * 2016-04-13 2019-05-30 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． 造影剤

Also Published As

Publication number Publication date
AU1613992A (en) 1992-11-12
DK0512661T3 (da) 1998-09-14
NO921832L (no) 1992-11-11
NO302951B1 (no) 1998-05-11
IE921504A1 (en) 1992-11-18
NZ242683A (en) 1995-04-27
EP0512661B1 (de) 1998-01-14
EP0512661A1 (de) 1992-11-11
NO921832D0 (no) 1992-05-08
ATE162082T1 (de) 1998-01-15
ZA923394B (en) 1993-01-27
CA2068266A1 (en) 1992-11-11
DE59209127D1 (de) 1998-02-19
IL101817A0 (en) 1992-12-30
ES2113918T3 (es) 1998-05-16
GR3026249T3 (en) 1998-05-29
US5876698A (en) 1999-03-02
IL101817A (en) 1998-03-10
AU661305B2 (en) 1995-07-20
DE4115789A1 (de) 1992-11-12

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