JPH05313105A - Contact lens and its production - Google Patents
Contact lens and its productionInfo
- Publication number
- JPH05313105A JPH05313105A JP11537092A JP11537092A JPH05313105A JP H05313105 A JPH05313105 A JP H05313105A JP 11537092 A JP11537092 A JP 11537092A JP 11537092 A JP11537092 A JP 11537092A JP H05313105 A JPH05313105 A JP H05313105A
- Authority
- JP
- Japan
- Prior art keywords
- silk fibroin
- contact lens
- aqueous solution
- weight
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
- B29D11/00—Producing optical elements, e.g. lenses or prisms
- B29D11/00009—Production of simple or compound lenses
- B29D11/00038—Production of contact lenses
Landscapes
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Ophthalmology & Optometry (AREA)
- Mechanical Engineering (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Eyeglasses (AREA)
- Manufacture Of Macromolecular Shaped Articles (AREA)
Abstract
(57)【要約】
【目的】 酸素透過性、光学特性、機械的強度において
すぐれるとともに、装着感に優れ、さらに汚れにくく、
かつ生体親和性にすぐれたコンタクトレンズ及びその製
造方法を提供する。
【構成】 絹フィブロインの透明固形物からなるコンタ
クトレンズ。絹フィブロインを５〜３０重量％含有し、
実質的に電解質不純物を含有しない絹フィブロイン水溶
液を容器に入れ、該水溶液の水分を蒸発除して絹フィブ
ロイン固形物を作り、この固形物をコンタクトレンズ状
に切削研磨することを特徴とするコンタクトレンズの製
造方法。(57) [Abstract] [Purpose] Oxygen permeability, optical properties, and mechanical strength are excellent, and it is comfortable to wear, and is also resistant to stains.
A contact lens excellent in biocompatibility and a method for manufacturing the same are also provided. [Constitution] A contact lens made of a transparent solid substance of silk fibroin. Contains 5 to 30% by weight of silk fibroin,
A contact lens characterized in that a silk fibroin aqueous solution containing substantially no electrolyte impurities is placed in a container, the water content of the aqueous solution is removed by evaporation to form a silk fibroin solid matter, and this solid matter is cut and ground into a contact lens shape. Manufacturing method.
Description
【０００１】[0001]
【産業上の利用分野】本発明はコンタクトレンズ及びそ
の製造方法に関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a contact lens and a method for manufacturing the same.
【０００２】[0002]
【従来技術及びその問題点】従来、コンタクトレンズ用
素材としては、光学特性、機械的強度及び機械的加工性
に優れたポリメチルメタクリレート（ＰＭＭＡ）を主成
分とする素材が使用されてきたが、近年では、角膜の新
陳代謝を適正に保つためにコンタクトレンズを通しての
酸素の供給が重要視されるようになり、酸素透過性高分
子、例えば、シリコンやフッ素原子を含むポリマーがＰ
ＭＭＡに代って使用されるようになってきた。シリコン
含有ポリマーとしては、シリコンラバーがある他、シロ
キサン結合を有するアクリレート、メタクリレート、ス
チリル等を一成分とするポリマーが挙げられる。一方、
フッ素含有ポリマーとしては、側鎖にパーフルオロ基を
持つアクリレートやメタクリレートを一成分とするポリ
マーが挙げられる。しかし、これらのポリマー素材から
なるコンタクトレンズは、一般的に撥水性が強く、ま
た、表面の親水性が劣るために装着時の異物感が強く、
しかも分泌物が付着しやすいために曇り易くなる等の欠
点が指摘されている。このようなポリマー素材の親水
性、即ち、濡れ性を改善するために、種々の表面処理が
検討されてきた。例えば、特公昭５８−３９４５０号、
特開昭５７−３５４４３号、特開昭５８−１７４４１２
号の各公報には後処理により親水性官能基を有する重合
性成分をコンタクトレンズに結合させる方法が開示され
ている。また、特公昭５５−４９２８８号、特開昭５８
−２１６２２２号の各公報には、プラズマ表面処理か或
いはプラズマ重合によりコンタクトレンズ表面の親水性
を改良する方法が開示されている。しかしながら、親水
性官能基を後処理法によってコンタクトレンズに結合さ
せる方法においては、親水化の可能な素材が限定される
上に、素材の酸素透過性が低下するという欠点があり、
しかもその親水性化処理も難しく、この処理操作中にレ
ンズの表面を損う危険が多く好ましくない。また、プラ
ズマ処理やプラズマ重合によりコンタクトレンズの表面
に親水基を導入する方法では、その親水基の耐久性が悪
く、長時間の経過後にはその親水性が著しく低下すると
いう欠点がある。2. Description of the Related Art Conventionally, as a material for a contact lens, a material containing polymethyl methacrylate (PMMA) as a main component, which is excellent in optical characteristics, mechanical strength and mechanical workability, has been used. In recent years, in order to keep the metabolism of the cornea proper, the supply of oxygen through contact lenses has become important, and oxygen-permeable polymers such as polymers containing silicon and fluorine atoms are
It has come to be used instead of MMA. Examples of the silicon-containing polymer include silicon rubber, and polymers having siloxane bond-containing acrylate, methacrylate, styryl and the like as one component. on the other hand,
Examples of the fluorine-containing polymer include a polymer containing acrylate or methacrylate having a perfluoro group in the side chain as one component. However, contact lenses made of these polymer materials generally have strong water repellency, and because the hydrophilicity of the surface is inferior, the feeling of foreign matter at the time of wearing is strong,
In addition, it has been pointed out that there are drawbacks such that the secretion easily adheres and the clouding easily occurs. Various surface treatments have been investigated in order to improve the hydrophilicity, that is, the wettability of such polymer materials. For example, Japanese Examined Patent Publication No. 58-39450,
JP-A-57-35443 and JP-A-58-174412
Each of the publications discloses a method of binding a polymerizable component having a hydrophilic functional group to a contact lens by post-treatment. Also, Japanese Examined Patent Publication No. 55-49288 and Japanese Patent Laid-Open No. 58-58
Each of the publications of -216222 discloses a method of improving hydrophilicity of a contact lens surface by plasma surface treatment or plasma polymerization. However, in the method of bonding a hydrophilic functional group to a contact lens by a post-treatment method, there is a drawback that the material that can be hydrophilized is limited and the oxygen permeability of the material is reduced,
Moreover, the hydrophilic treatment is also difficult, and there is a great risk of damaging the surface of the lens during this treatment operation, which is not preferable. In addition, the method of introducing a hydrophilic group to the surface of the contact lens by plasma treatment or plasma polymerization has a drawback that the durability of the hydrophilic group is poor and the hydrophilicity is significantly lowered after a long time.
【０００３】[0003]
【発明が解決しようとする課題】本発明は、酸素透過
性、光学特性、機械的強度においてすぐれるとともに、
装着感に優れ、さらに汚れにくく、かつ生体親和性にす
ぐれたコンタクトレンズ及びその製造方法を提供するこ
とをその課題とする。The present invention is excellent in oxygen permeability, optical characteristics and mechanical strength, and
It is an object of the present invention to provide a contact lens which is excellent in wearing feeling, is less likely to become dirty, and has excellent biocompatibility, and a method for manufacturing the same.
【０００４】[0004]
【課題を解決するための手段】本発明者らは、前記課題
を解決すべく鋭意研究を重ねた結果、昆虫由来の天然高
分子である絹フィブロインをコンタントレンズ素材に用
いることによって、前記課題を解決し得ることを見出
し、本発明を完成するに至った。即ち、本発明によれ
ば、絹フィブロインの透明固形物からなるコンタクトレ
ンズが提供される。また、本発明によれば、絹フィブロ
インを５〜３０重量％含有し、実質的に電解質不純物を
含有しない絹フィブロイン水溶液を容器に入れ、該水溶
液の水分を蒸発除して絹フィブロイン固形物を作り、こ
の固形物をコンタクトレンズ状に切削研磨することを特
徴とするコンタクトレンズの製造方法が提供される。Means for Solving the Problems The inventors of the present invention have conducted extensive studies to solve the above problems, and as a result, by using silk fibroin, which is a natural polymer derived from insects, as a material for the contact lens, the above problems have been solved. The present invention has been completed and the present invention has been completed. That is, according to the present invention, there is provided a contact lens made of a transparent solid substance of silk fibroin. Further, according to the present invention, a silk fibroin aqueous solution containing 5 to 30% by weight of silk fibroin and containing substantially no electrolyte impurities is placed in a container, and the water content of the aqueous solution is removed by evaporation to prepare a silk fibroin solid product. Provided is a method for manufacturing a contact lens, which comprises cutting and polishing this solid material into a contact lens shape.
【０００５】本発明においては、コンタクトレンズ素材
として、絹フィブロインを用いる。絹フィブロインとし
ては、従来公知の各種のものが用いられ、例えば、家蚕
由来の絹フィブロインはもとより、非蚕、天蚕及びエリ
蚕由来の絹フィブロインを用いることができる。また、
絹フィブロインは、まゆ糸や生糸を精製した絹フィブロ
インをいったん溶解して調製した再生絹フィブロインで
あってもよく、また蚕体内より取出した絹糸腺内の液状
フィブロインであってもよい。In the present invention, silk fibroin is used as the contact lens material. As the silk fibroin, various conventionally known ones can be used. For example, silk fibroin derived from domestic silkworm, as well as silk fibroin derived from non-silkworm, celestial silkworm and eri silkworm can be used. Also,
The silk fibroin may be regenerated silk fibroin prepared by once dissolving silk fibroin obtained by purifying eyebrows or raw silk, or liquid fibroin in the silk gland taken out from the silkworm body.
【０００６】本発明のコンタクトレンズを製造するに
は、先ず、絹フィブロインを５〜３０重量％含有し、実
質的に電解質不純物を含有しない絹フィブロイン水溶液
を調製する。このような絹フィブロイン水溶液の調製は
従来公知の方法によって行うことができ、その１例を以
下に示す。まゆ糸や生糸を０．２重量％マルセル石鹸と
０．０５重量％の炭酸ソーダの混合溶液に浸漬し、９８
℃で１時間精練処理することにより繊維表面の絹セリシ
ンを除去する。こうして作製した絹フィブロイン繊維は
濃厚な塩化カルシウム水溶液、硝酸カルシウム水溶液、
臭化リチウム水溶液、或はチオシアン酸リチウム水溶液
等の中性塩水溶液に溶解するので、これらを用いて絹フ
ィブロイン水溶液を調製することができる。即ち、これ
らの中性塩水溶液に絹フィブロイン繊維を溶解して絹フ
ィブロイン水溶液とした後、セルロース製の透析膜で透
析処理し、その水溶液中に含まれるリチウムイオン、カ
ルシウムイオン、チオシアン酸イオン、ブロムイオン、
或はクロルイオン等を水溶液中から除去する。これによ
って電解質不純物を実質的に含まない絹フィブロイン水
溶液を得ることができる。この水溶液には、必要に応じ
て、着色剤や紫外線吸収剤を添加することもできる。こ
のようにして調製した絹フィブロイン水溶液をポリエチ
レン製膜上に広げ、送風乾燥させて、絹フィブロイン水
溶液を濃縮させる。これを冷蔵庫中に一日放置してさら
に濃縮して、絹フィブロイン濃度が５〜３０重量％、好
ましくは７〜２０重量％の絹フィブロイン水溶液を得
る。本発明においては、次に、前記のようにして得た５
〜３０重量％の絹フィブロイン水溶液をポリエチレン製
容器に入れ、さらに乾燥を継続することによって、ブロ
ック状の絹フィブロイン固形物を得る。ポリエチレン製
容器に充填した絹フィブロイン水溶液の乾燥は、５〜９
０℃、好ましくは２０〜５０℃の恒温槽で実施すること
ができ、この乾燥によって容器の形状に対応した形状の
透明な絹フィブロイン固形物が得られる。なお、絹フィ
ブロイン水溶液を充填する容器はポリエチレン製に限ら
れるものではなく、他の樹脂であることができ、またガ
ラスであることもできる。本発明においては、このよう
にして得られた透明な絹フィブロイン固形物を常法によ
りコンタクトレンズ状に切削研磨することによってコン
タクトレンズを得る。このコンタクトレンズは、使用に
際し、８〜１５重量％の水分を吸収させ、この水分吸収
状態で装用される。In order to manufacture the contact lens of the present invention, first, an aqueous silk fibroin solution containing 5 to 30% by weight of silk fibroin and containing substantially no electrolyte impurities is prepared. Such an aqueous silk fibroin solution can be prepared by a conventionally known method, one example of which is shown below. Immerse the eyebrows or raw silk in a mixed solution of 0.2 wt% Marcel soap and 0.05 wt% sodium carbonate,
Silk sericin on the fiber surface is removed by scouring at 1 ° C for 1 hour. The silk fibroin fiber thus prepared is a concentrated calcium chloride aqueous solution, calcium nitrate aqueous solution,
Since it is dissolved in an aqueous solution of a neutral salt such as an aqueous solution of lithium bromide or an aqueous solution of lithium thiocyanate, an aqueous silk fibroin solution can be prepared using them. That is, silk fibroin fibers were dissolved in these neutral salt aqueous solutions to obtain silk fibroin aqueous solution, which was then dialyzed with a dialysis membrane made of cellulose to obtain lithium ions, calcium ions, thiocyanate ions, and bromine contained in the aqueous solution. ion,
Alternatively, chlorine ions and the like are removed from the aqueous solution. As a result, an aqueous silk fibroin solution containing substantially no electrolyte impurities can be obtained. A coloring agent or an ultraviolet absorber may be added to the aqueous solution, if necessary. The aqueous silk fibroin solution thus prepared is spread on a polyethylene membrane and dried by blowing air to concentrate the aqueous silk fibroin solution. This is left for one day in a refrigerator and further concentrated to obtain an aqueous silk fibroin solution having a silk fibroin concentration of 5 to 30% by weight, preferably 7 to 20% by weight. In the present invention, next, 5 obtained as described above is used.
A silk fibroin solid product in a block form is obtained by placing a silk fibroin aqueous solution of ˜30 wt% in a polyethylene container and continuing the drying. Drying the silk fibroin aqueous solution filled in a polyethylene container takes 5 to 9
It can be carried out in a constant temperature bath at 0 ° C., preferably 20 to 50 ° C., and by this drying, a transparent silk fibroin solid having a shape corresponding to the shape of the container is obtained. The container for filling the silk fibroin aqueous solution is not limited to polyethylene, but may be other resin or glass. In the present invention, a contact lens is obtained by cutting and polishing the thus obtained transparent silk fibroin solid matter into a contact lens shape by a conventional method. When used, this contact lens absorbs 8 to 15% by weight of water and is worn in this water absorption state.
【０００７】[0007]
【実施例】次に、本発明を実施例により詳細に説明する
が、本発明はこれらの実施例により何ら限定されるもの
ではない。 実施例１ 精練した絹フィブロイン繊維６ｇを２ｇずつ３回に分け
て８．５モル濃度の臭化リチウム（ＬｉＢｒ・Ｈ2Ｏ）
水溶液２０ｍｌに加えて５５℃で撹拌しながら溶解処理
する。約３０分後に完全に溶解した溶液をセルロース製
透析膜に入れて水道水で３日間透析し、リチウムイオン
とブロムイオンを除去する。次に、純水に置換して５℃
の条件で、さらに２日間透析する。こうして得られた電
解質不純物を含まない絹フィブロイン水溶液をポリエチ
レン膜上に広げて、送風乾燥させて濃縮する。さらに、
５℃の冷蔵庫に解放状態で一日放置して乾燥濃縮する。
こうして得られた約９．５重量％の絹フィブロイン水溶
液２０ｍｌを直径３０ｍｍ、高さ５０ｍｍのポリエチレ
ン製容器に入れ、２５℃の恒温室で２日間解放状態で乾
燥する。この操作によって直径２５ｍｍ、高さ８ｍｍの
透明なブロック状絹フィブロイン固形物を得る。この固
形物から通常の切削研磨法によってコンタクトレンズを
作製した。これを保存液に２日間浸漬して約１２重量％
の水を吸水したコンタクトレンズを得た。EXAMPLES Next, the present invention will be described in detail with reference to examples, but the present invention is not limited to these examples. Example 1 6 g of refined silk fibroin fiber was divided into 3 times by 2 g, and lithium bromide (LiBr.H 2 O) having a concentration of 8.5 mol was obtained.
The solution is added to 20 ml of an aqueous solution and dissolved at 55 ° C. with stirring. After about 30 minutes, the completely dissolved solution is put into a cellulose dialysis membrane and dialyzed with tap water for 3 days to remove lithium ion and bromide ion. Next, replace with pure water and
Dialyze for another 2 days under the above conditions. The thus obtained aqueous silk fibroin solution containing no electrolyte impurities is spread on a polyethylene membrane, blown and dried, and concentrated. further,
Leave it open in a refrigerator at 5 ° C for one day to dry and concentrate.
20 ml of a silk fibroin aqueous solution of about 9.5% by weight thus obtained is placed in a polyethylene container having a diameter of 30 mm and a height of 50 mm and dried in a thermostatic chamber at 25 ° C. for 2 days in an open state. By this operation, a transparent block-like silk fibroin solid substance having a diameter of 25 mm and a height of 8 mm is obtained. A contact lens was produced from this solid by a usual cutting and polishing method. Soak this in the preservation solution for 2 days to get about 12% by weight.
A contact lens that absorbed the above water was obtained.
【０００８】実施例２ 精練済みの絹フィブロイン繊維６ｇを２ｇずつ３回に分
けてチオシアン酸リチウム（ＬｉＳＣＮ・２Ｈ2Ｏ）３
４ｇ、水１０ｍｌからなる水溶液に加えて４５℃で約３
０分溶解処理をした。以下、実施例１と同様に操作し、
透明なブロック状の絹フィブロイン固形物を得、切削研
磨法によってコンタクトレンズを作製した。これを保存
液に２日間浸漬して約１３重量％の水を吸水したコンタ
クトレンズを得た。Example 2 6 g of scoured silk fibroin fiber was divided into 3 parts by 2 g, and lithium thiocyanate (LiSCN.2H 2 O) 3
Add 3g at 45 ° C to an aqueous solution consisting of 4g and 10ml of water.
It was dissolved for 0 minutes. Hereinafter, the same operation as in Example 1,
A transparent block-shaped solid silk fibroin material was obtained, and a contact lens was prepared by a cutting and polishing method. This was immersed in a preservative solution for 2 days to obtain a contact lens absorbing about 13% by weight of water.
【０００９】実施例３ 精練済みの絹フィブロイン繊維６ｇを２ｇずつ３回に分
けて、煮沸直後の塩化カルシウム（ＣａＣｌ2・２Ｈ
2Ｏ）：エタノール：水＝１：２：８（ｍｏｌ％）から
なる水溶液５０ｇに添加して徐冷しながら溶解処理をす
る。以下、実施例１と同様に操作し、透明なブロック状
の絹フィブロイン固形物を得、切削研磨法によってコン
タクトレンズを作製した。これを保存液に２日間浸漬し
て１０．５重量％の水を吸水したコンタクトレンズを得
た。Example 3 6 g of scoured silk fibroin fiber was divided into 3 times by 2 g, and calcium chloride (CaCl 2 .2H) immediately after boiling was added.
2 O): Ethanol: water = 1: 2: 8 (mol%) is added to 50 g of an aqueous solution, and a dissolution treatment is performed while gradually cooling. Thereafter, the same operation as in Example 1 was carried out to obtain a transparent block-shaped solid silk fibroin material, and a contact lens was produced by a cutting and polishing method. This was immersed in a storage solution for 2 days to obtain a contact lens absorbing 10.5% by weight of water.
【００１０】実施例４ 天蚕のまゆ繊維を繊維重量に対して５０倍量の０．１重
量％の過酸化ナトリウム水溶液に浸漬し、９８℃で１時
間処理して絹セリシンを除去した。この絹セリシンを除
去して得られた天蚕絹フィブロイン繊維を８Ｍチオシア
ン酸リチウム（ＬｉＳＣＮ・Ｈ2Ｏ）水溶液に加えて、
３５℃で３０分で溶解させる。以下、実施例１と同様に
操作し、透明なブロック状の絹フィブロイン固形物を
得、切削研磨法によってコンタクトレンズを作製した。
これを保存液に２日間浸漬して約１１重量％の水を吸水
したコンタクトレンズを得た。Example 4 The silkworm eyebrows fibers were immersed in an aqueous solution of 0.1% by weight of sodium peroxide in an amount 50 times the weight of the fibers, and treated at 98 ° C. for 1 hour to remove silk sericin. The silkworm silk fibroin fiber obtained by removing the silk sericin was added to an 8M lithium thiocyanate (LiSCN.H 2 O) aqueous solution,
Dissolve in 35 minutes at 35 ° C. Thereafter, the same operation as in Example 1 was carried out to obtain a transparent block-shaped solid silk fibroin material, and a contact lens was produced by a cutting and polishing method.
This was immersed in a preservative solution for 2 days to obtain a contact lens absorbing about 11% by weight of water.
【００１１】これらのコンタクトレンズ試料について、
その外観、性状、硬度（ビッカース硬度）、酸素透過係
数〔１０-11ｍｌ（Ｏ2）ｃｍ／ｃｍ2・ｓｅｃ・ｍｍ／
ｌｇ〕、耐汚染性及び生体親和性を評価した。その結果
を表１に示す。また、表１には、比較のために、ポリメ
チルメタクリレートから作製したコンタクトレンズの評
価結果を比較例として示す。尚、生体親和性はコンタク
トレンズ試料を１週間装用したときの装用感を以下の如
く５段階に分けて評価した。 （生体親和性の評価基準）： ａ：非常に良好（異物感が感じられない） ｂ：良好（異物感がほとんど感じられない） ｃ：普通（やや異物感が感じられる） ｄ：異物感あり ｅ：異物感が強い また、耐汚染性は以下のようにして評価した。卵白リゾ
チーム０．１ｇ、ムチン０．１ｇ及びアルブミン０．１
ｇを純水１００ｍｌに溶解し、リン酸水素二ナトリウム
（無水）水溶液とリン酸二水素ナトリウム（無水）水溶
液でｐＨ７．２に調整する。これを汚染液（Ａ）とす
る。この汚染液（Ａ）１ｍｌにレンズ１枚を６０〜７０
℃で１５分浸漬後、室温で乾燥する。本操作を５回繰り
返した後、指で軽くこすりながら精製水で洗浄し乾燥し
たレンズを肉眼で観察する。Regarding these contact lens samples,
Its appearance, properties, hardness (Vickers hardness), oxygen permeability coefficient [10 -11 ml (O 2 ) cm / cm 2 · sec · mm /
lg], stain resistance and biocompatibility were evaluated. The results are shown in Table 1. In addition, Table 1 shows, as a comparative example, evaluation results of a contact lens made of polymethylmethacrylate for comparison. The biocompatibility was evaluated by categorizing the wearing feeling when the contact lens sample was worn for 1 week into 5 stages as follows. (Evaluation criteria for biocompatibility): a: Very good (feeling no foreign body is felt) b: Good (almost no feeling of foreign body is felt) c: Normal (a little foreign body feel is felt) d: There is a foreign body feel e: Strong sense of foreign matter The stain resistance was evaluated as follows. Egg white lysozyme 0.1 g, mucin 0.1 g and albumin 0.1
g is dissolved in 100 ml of pure water, and the pH is adjusted to 7.2 with a disodium hydrogen phosphate (anhydrous) aqueous solution and a sodium dihydrogen phosphate (anhydrous) aqueous solution. This is designated as a contaminated liquid (A). 1 lens of this contaminated liquid (A) is 60 to 70
After soaking at 15 ° C for 15 minutes, it is dried at room temperature. After repeating this operation 5 times, wash the lens with purified water while rubbing lightly with a finger and observe the dried lens with the naked eye.
【００１２】[0012]
【表１】 [Table 1]
【００１３】[0013]
【発明の効果】本発明のコンタクトレンズは、生体反応
性が少ない昆虫由来の生体高分子である純粋な絹フィブ
ロインを素材としているため安全である上、表１に示し
た評価結果からわかるように、酸素透過性及び水濡れ性
が良く、かつ耐汚染性に優れ、さらに従来の合成高分子
素材では得られないすぐれた生体親和性を有する画期的
なものである。EFFECTS OF THE INVENTION The contact lens of the present invention is safe because it is made of pure silk fibroin, which is a biopolymer derived from insects with low bioreactivity, and is safe, and as can be seen from the evaluation results shown in Table 1. It is epoch-making that it has good oxygen permeability and water wettability, excellent stain resistance, and excellent biocompatibility that cannot be obtained by conventional synthetic polymer materials.
───────────────────────────────────────────────────── フロントページの続き (72)発明者 塚田 益裕 茨城県つくば市松代４−401−403 (72)発明者 箕浦 憲彦 茨城県つくば市東１丁目１番４号 工業技 術院製品科学研究所内 (72)発明者 菊田 吉則 埼玉県浦和市瀬ヶ崎五丁目25−11 (72)発明者 村山 美和 埼玉県浦和市大谷口1371 ─────────────────────────────────────────────────── ─── Continued Front Page (72) Inventor Masuhiro Tsukada 4-401-403 Matsushiro Tsukuba, Ibaraki Prefecture (72) Inventor Norihiko Minoura 1-4-1 Higashi Tsukuba, Ibaraki Institute of Industrial Science and Technology (72) Inventor Yoshinori Kikuta 25--11, Segasaki, Urawa-shi, Saitama Prefecture (72) Inventor Miwa Murayama 1371 Otaniguchi, Urawa-shi, Saitama Prefecture
Claims (2)
ンタクトレンズ。1. A contact lens comprising a transparent solid substance of silk fibroin.
し、実質的に電解質不純物を含有しない絹フィブロイン
水溶液を容器に入れ、該水溶液の水分を蒸発除して絹フ
ィブロイン固形物を作り、この固形物をコンタクトレン
ズ状に切削研磨することを特徴とするコンタクトレンズ
の製造方法。2. A silk fibroin aqueous solution containing 5 to 30% by weight of silk fibroin and containing substantially no electrolyte impurities is placed in a container, and the water content of the aqueous solution is removed by evaporation to form a silk fibroin solid product. A method for manufacturing a contact lens, which comprises cutting and polishing an object into a contact lens shape.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4115370A JP2740822B2 (en) | 1992-04-08 | 1992-04-08 | Contact lens and manufacturing method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4115370A JP2740822B2 (en) | 1992-04-08 | 1992-04-08 | Contact lens and manufacturing method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH05313105A true JPH05313105A (en) | 1993-11-26 |
| JP2740822B2 JP2740822B2 (en) | 1998-04-15 |
Family
ID=14660850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4115370A Expired - Fee Related JP2740822B2 (en) | 1992-04-08 | 1992-04-08 | Contact lens and manufacturing method thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2740822B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5789462A (en) * | 1995-09-13 | 1998-08-04 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Photocured crosslinked-hyaluronic acid contact lens |
| US6075066A (en) * | 1994-03-14 | 2000-06-13 | Seikagaku Kogyo Kabushiki Kaisha | Material to be worn on the eyeball |
| CN115339135A (en) * | 2022-08-09 | 2022-11-15 | 重庆大学 | Preparation method of silk fibroin colored contact lens |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63246169A (en) * | 1987-03-31 | 1988-10-13 | 工業技術院長 | Oxygen permeable membrane |
-
1992
- 1992-04-08 JP JP4115370A patent/JP2740822B2/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63246169A (en) * | 1987-03-31 | 1988-10-13 | 工業技術院長 | Oxygen permeable membrane |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6075066A (en) * | 1994-03-14 | 2000-06-13 | Seikagaku Kogyo Kabushiki Kaisha | Material to be worn on the eyeball |
| US5789462A (en) * | 1995-09-13 | 1998-08-04 | Seikagaku Kogyo Kabushiki Kaisha (Seikagaku Corporation) | Photocured crosslinked-hyaluronic acid contact lens |
| CN115339135A (en) * | 2022-08-09 | 2022-11-15 | 重庆大学 | Preparation method of silk fibroin colored contact lens |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2740822B2 (en) | 1998-04-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4139513A (en) | Copolymer for soft contact lens, its preparation and soft contact lens made thereof | |
| US4139692A (en) | Copolymer for contact lens, its preparation and contact lens made thereof | |
| JP2619245B2 (en) | Transparent polymer material for hydrogel contact lenses and optically transparent hydrophilic contact lens comprising the same | |
| ES2328009T3 (en) | SOFT CONTACT LENS WITH CAPACITY TO BE USED LONG TERM. | |
| US5475450A (en) | Protein deposition resistant contact lens | |
| US5708050A (en) | Oxygen permeable contact lens having high durable hydrophilic surface and method for producing the same | |
| US4650843A (en) | Soft contact lens | |
| SU1053761A3 (en) | Method for making modified contact lenses | |
| JPS5977411A (en) | Oxygen permeating hard contact lens | |
| US4152283A (en) | Restoring agent for soft contact lenses | |
| EP0073649A2 (en) | Surface-treated soft contact lenses | |
| JPH01158412A (en) | Cleaning and preserving liquid for contact lens | |
| US4395346A (en) | Method for cleaning contact lenses | |
| JP4194291B2 (en) | Process for producing undegraded silk fibroin aqueous solution and skin care agent containing the same | |
| JP2740822B2 (en) | Contact lens and manufacturing method thereof | |
| CA1163906A (en) | Process for removing contaminants on contact lenses | |
| CN105111479A (en) | Method for modifying fluorinated siloxane acrylate material of rigid gas-permeable corneal contact lens | |
| JPH03259927A (en) | Gel composition and its production | |
| CN115128839A (en) | Method for preparing silk fibroin contact lenses based on natural silk | |
| KR100214747B1 (en) | Contact lens and method of producing a contact lens | |
| US4284749A (en) | Continuous wear hydratable, boilable methylmethacrylate copolymer contact lens | |
| JPH04114016A (en) | Material for water-containing soft contact lens | |
| CN115339135A (en) | Preparation method of silk fibroin colored contact lens | |
| GB2040492A (en) | Method and Composition for Treating Contact Lenses | |
| JP3629571B2 (en) | Method for producing silk fibroin lump and contact lens comprising the lump |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |