JPH05344894A - ミコバクテリウム・ツベルクロシス（ Ｍｙｃｏｂａｃｔｅｒｉｕｍ ｔｕｂｅｒｃｕｌｏｓｉｓ ）の ３８ ｋＤａ 抗原発現用のハイブリッドプラスミド、ハイブリッドプラスミドの宿主としてのエシエリキア・コリ（Ｅｓｃｈｅｒｉｃｈｉａ ｃｏｌｉ）、 ３８ ｋＤａ 抗原及び約 ３３ ｋＤａ の大きさのタンパク質 - Google Patents

ミコバクテリウム・ツベルクロシス（ Ｍｙｃｏｂａｃｔｅｒｉｕｍ ｔｕｂｅｒｃｕｌｏｓｉｓ ）の ３８ ｋＤａ 抗原発現用のハイブリッドプラスミド、ハイブリッドプラスミドの宿主としてのエシエリキア・コリ（Ｅｓｃｈｅｒｉｃｈｉａ ｃｏｌｉ）、 ３８ ｋＤａ 抗原及び約 ３３ ｋＤａ の大きさのタンパク質

Info

Publication number
JPH05344894A
JPH05344894A JP4149895A JP14989592A JPH05344894A JP H05344894 A JPH05344894 A JP H05344894A JP 4149895 A JP4149895 A JP 4149895A JP 14989592 A JP14989592 A JP 14989592A JP H05344894 A JPH05344894 A JP H05344894A
Authority
JP
Japan
Prior art keywords
kda
antigen
protein
escherichia coli
mycobacterium tuberculosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4149895A
Other languages
English (en)
Japanese (ja)
Inventor
Mahavir Dr Singh
マハビヤ・シン
Kenneth Nigel Timmis
ケニス・ナイジェル・ティムス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GES BIOTECHNOL FORSCH MBH <GBF>
Original Assignee
GES BIOTECHNOL FORSCH MBH <GBF>
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GES BIOTECHNOL FORSCH MBH <GBF> filed Critical GES BIOTECHNOL FORSCH MBH <GBF>
Publication of JPH05344894A publication Critical patent/JPH05344894A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/35—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Mycobacteriaceae (F)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
JP4149895A 1991-05-17 1992-05-18 ミコバクテリウム・ツベルクロシス（ Ｍｙｃｏｂａｃｔｅｒｉｕｍ ｔｕｂｅｒｃｕｌｏｓｉｓ ）の ３８ ｋＤａ 抗原発現用のハイブリッドプラスミド、ハイブリッドプラスミドの宿主としてのエシエリキア・コリ（Ｅｓｃｈｅｒｉｃｈｉａ ｃｏｌｉ）、 ３８ ｋＤａ 抗原及び約 ３３ ｋＤａ の大きさのタンパク質 Pending JPH05344894A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4116249A DE4116249A1 (de) 1991-05-17 1991-05-17 Hybrid-plasmid fuer m.-tuberculosis-antigen, e. coli als wirt und antigen
DE41-16-249-8 1991-05-17

Publications (1)

Publication Number Publication Date
JPH05344894A true JPH05344894A (ja) 1993-12-27

Family

ID=6431926

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4149895A Pending JPH05344894A (ja) 1991-05-17 1992-05-18 ミコバクテリウム・ツベルクロシス（ Ｍｙｃｏｂａｃｔｅｒｉｕｍ ｔｕｂｅｒｃｕｌｏｓｉｓ ）の ３８ ｋＤａ 抗原発現用のハイブリッドプラスミド、ハイブリッドプラスミドの宿主としてのエシエリキア・コリ（Ｅｓｃｈｅｒｉｃｈｉａ ｃｏｌｉ）、 ３８ ｋＤａ 抗原及び約 ３３ ｋＤａ の大きさのタンパク質

Country Status (8)

Country Link
US (1) US6110469A (fr)
EP (1) EP0519218B1 (fr)
JP (1) JPH05344894A (fr)
AT (1) ATE173506T1 (fr)
DE (2) DE4116249A1 (fr)
DK (1) DK0519218T3 (fr)
ES (1) ES2125873T3 (fr)
NZ (1) NZ242757A (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6752993B1 (en) 1993-11-23 2004-06-22 The Regents Of The University Of California Abundant extracellular product vaccines and methods for their production and use
US6290969B1 (en) 1995-09-01 2001-09-18 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
US6458366B1 (en) 1995-09-01 2002-10-01 Corixa Corporation Compounds and methods for diagnosis of tuberculosis
US6592877B1 (en) 1995-09-01 2003-07-15 Corixa Corporation Compounds and methods for immunotherapy and diagnosis of tuberculosis
EP0907751A2 (fr) * 1996-04-29 1999-04-14 Gesellschaft für Biotechnologische Forschung mbH (GBF) Adn, arn et proteine utiles pour dectecter une infection mycobacterienne
US6013660A (en) * 1996-10-02 2000-01-11 The Regents Of The University Of California Externally targeted prophylactic and chemotherapeutic method and agents
US7083796B2 (en) 2000-06-20 2006-08-01 Corixa Corporation Fusion proteins of mycobacterium tuberculosis
US8143386B2 (en) 1999-04-07 2012-03-27 Corixa Corporation Fusion proteins of mycobacterium tuberculosis antigens and their uses
EP1229931A4 (fr) 1999-10-07 2003-05-28 Corixa Corp Proteines hybrides de mycobacterium tuberculosis
GB9924351D0 (en) 1999-10-14 1999-12-15 Brennan Frank Immunomodulation methods and compositions
AU2001241738A1 (en) 2000-02-25 2001-09-03 Corixa Corporation Compounds and methods for diagnosis and immunotherapy of tuberculosis
US7026465B2 (en) 2002-02-15 2006-04-11 Corixa Corporation Fusion proteins of Mycobacterium tuberculosis
ITPR20040015A1 (it) * 2004-02-24 2004-05-24 Niro Soavi Spa Procedimento e apparato per la rottura cellulare in una sospensione fluida in continuo.
CN100350048C (zh) * 2005-07-21 2007-11-21 复旦大学 一种重组卡介苗及其制备方法
CN100457912C (zh) * 2005-07-21 2009-02-04 复旦大学 重组Ag85B卡介苗
US9642903B2 (en) 2009-07-16 2017-05-09 Lior Carmon Antigen specific multi epitope-based anti-infective vaccines

Also Published As

Publication number Publication date
ES2125873T3 (es) 1999-03-16
EP0519218A2 (fr) 1992-12-23
ATE173506T1 (de) 1998-12-15
US6110469A (en) 2000-08-29
DE59209560D1 (de) 1998-12-24
NZ242757A (en) 1993-09-27
DE4116249A1 (de) 1992-11-19
EP0519218A3 (en) 1993-10-20
DK0519218T3 (da) 1999-08-02
EP0519218B1 (fr) 1998-11-18

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