JPH0550273B2 - - Google Patents
Info
- Publication number
- JPH0550273B2 JPH0550273B2 JP60502445A JP50244585A JPH0550273B2 JP H0550273 B2 JPH0550273 B2 JP H0550273B2 JP 60502445 A JP60502445 A JP 60502445A JP 50244585 A JP50244585 A JP 50244585A JP H0550273 B2 JPH0550273 B2 JP H0550273B2
- Authority
- JP
- Japan
- Prior art keywords
- ifn
- protein
- cells
- interferon
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 108010074328 Interferon-gamma Proteins 0.000 abstract description 90
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- 102000008070 Interferon-gamma Human genes 0.000 abstract description 12
- 229940044627 gamma-interferon Drugs 0.000 abstract description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract description 10
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- 101000959820 Homo sapiens Interferon alpha-1/13 Proteins 0.000 description 23
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- 102000014150 Interferons Human genes 0.000 description 19
- 108010050904 Interferons Proteins 0.000 description 19
- 229940079322 interferon Drugs 0.000 description 15
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 12
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- PXXJHWLDUBFPOL-UHFFFAOYSA-N benzamidine Chemical compound NC(=N)C1=CC=CC=C1 PXXJHWLDUBFPOL-UHFFFAOYSA-N 0.000 description 7
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- PJJJBBJSCAKJQF-UHFFFAOYSA-N guanidinium chloride Chemical group [Cl-].NC(N)=[NH2+] PJJJBBJSCAKJQF-UHFFFAOYSA-N 0.000 description 4
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
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- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 3
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- HBOMLICNUCNMMY-KJFJCRTCSA-N 1-[(4s,5s)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound O=C1NC(=O)C(C)=CN1C1O[C@H](CO)[C@@H](N=[N+]=[N-])C1 HBOMLICNUCNMMY-KJFJCRTCSA-N 0.000 description 2
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/57—IFN-gamma
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/811—Interferon
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Description
è«æ±ã®ç¯å²
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8414354 | 1984-06-05 | ||
| GB848414354A GB8414354D0 (en) | 1984-06-05 | 1984-06-05 | Purifying protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS62500072A JPS62500072A (ja) | 1987-01-16 |
| JPH0550273B2 true JPH0550273B2 (ja) | 1993-07-28 |
Family
ID=10561969
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP60502445A Granted JPS62500072A (ja) | 1984-06-05 | 1985-06-04 | èçœè³ªã®ç²Ÿè£œæ³ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US4828989A (ja) |
| EP (1) | EP0189431B1 (ja) |
| JP (1) | JPS62500072A (ja) |
| AT (1) | ATE71110T1 (ja) |
| DE (1) | DE3585084D1 (ja) |
| GB (1) | GB8414354D0 (ja) |
| WO (1) | WO1985005637A1 (ja) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5792450A (en) * | 1985-02-05 | 1998-08-11 | Chiron Corporation | Purified human CSF-1 |
| US4748234A (en) * | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| US4683293A (en) * | 1986-10-20 | 1987-07-28 | Phillips Petroleum Company | Purification of pichia produced lipophilic proteins |
| EP0272483A1 (en) * | 1986-12-19 | 1988-06-29 | Abbott Laboratories | Methods and materials for HBeAg production |
| CA1339757C (en) * | 1987-04-16 | 1998-03-17 | Robert F. Halenbeck | Production of purified biologically active, bacterially produced recombinant human csf-1 |
| US4929700A (en) * | 1987-04-16 | 1990-05-29 | Cetus Corporation | Production of purified, biologically active, bacterially produced recombinant human CSF-1 |
| US4961969A (en) * | 1987-05-11 | 1990-10-09 | Cetus Corporation | Process for recovering microbially produced interferon-β |
| US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
| DE3808048A1 (de) * | 1988-03-11 | 1989-09-21 | Behringwerke Ag | Verfahren zum affinitaetschromatografischen reinigen von faktor xiii |
| US4999422A (en) * | 1988-04-15 | 1991-03-12 | Biogen, N.V. | Continuous method of refolding proteins |
| US5530100A (en) * | 1990-05-07 | 1996-06-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Methods for purification of recombinantly produced proteins |
| IT1246296B (it) * | 1990-07-25 | 1994-11-17 | Sclavo Spa | Procedimento di estrzione e purificazione del gamma interferone umano ricombinante |
| KR100260631B1 (ko) * | 1992-08-03 | 2000-07-01 | ì±ì¬ê° | íì±í ìžê° ê°ë§ ìží°íë¡ ì ì ì¡°ë°©ë² ë° ê·žì ìíŽ ì ì¡°ë ëšë°±ì§ |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE431758B (sv) * | 1977-03-04 | 1984-02-27 | Pharmacia Fine Chemicals Ab | Som tioleringsreagens eller berarmatris for enzymer anvendbart derivat av en sh-grupphaltig polymer |
| SE448631B (sv) * | 1978-04-28 | 1987-03-09 | Toyo Jozo Kk | Disulfidforening av en berare med s-s-utbytesreaktivitet |
| FR2490675B1 (fr) * | 1980-09-25 | 1985-11-15 | Genentech Inc | Production microbienne d'interferon de fibroplaste humain |
| US4405601A (en) * | 1981-05-21 | 1983-09-20 | Cancer Research Center | Extraction and purification of biologically active lymphokines |
| IE53517B1 (en) * | 1981-06-17 | 1988-12-07 | Celltech Ltd | Process for the production of a polypeptide |
| AU561343B2 (en) * | 1981-10-19 | 1987-05-07 | Genentech Inc. | Human immune interferon by recombinant dna |
| WO1983004418A1 (en) * | 1982-06-07 | 1983-12-22 | Celltech Limited | A process for the preparation of chymosin |
| US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
| US4681930A (en) * | 1983-09-20 | 1987-07-21 | Hoffmann-La Roche Inc. | Immune interferon and a method for its extraction and purification |
| JPS6079000A (ja) * | 1983-10-04 | 1985-05-04 | Takeda Chem Ind Ltd | ããγåã€ã³ã¿âããšãã³åéäœã®è£œé æ³ |
-
1984
- 1984-06-05 GB GB848414354A patent/GB8414354D0/en active Pending
-
1985
- 1985-06-04 DE DE8585902604T patent/DE3585084D1/de not_active Expired - Fee Related
- 1985-06-04 WO PCT/GB1985/000236 patent/WO1985005637A1/en not_active Ceased
- 1985-06-04 EP EP85902604A patent/EP0189431B1/en not_active Expired
- 1985-06-04 US US06/828,327 patent/US4828989A/en not_active Expired - Fee Related
- 1985-06-04 AT AT85902604T patent/ATE71110T1/de not_active IP Right Cessation
- 1985-06-04 JP JP60502445A patent/JPS62500072A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| DE3585084D1 (de) | 1992-02-13 |
| WO1985005637A1 (en) | 1985-12-19 |
| GB8414354D0 (en) | 1984-07-11 |
| JPS62500072A (ja) | 1987-01-16 |
| ATE71110T1 (de) | 1992-01-15 |
| EP0189431A1 (en) | 1986-08-06 |
| US4828989A (en) | 1989-05-09 |
| EP0189431B1 (en) | 1992-01-02 |
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