JPH05507475A - ロイコトリエン関連疾患治療用安息香酸誘導体 - Google Patents

ロイコトリエン関連疾患治療用安息香酸誘導体

Info

Publication number
JPH05507475A
JPH05507475A JP91509448A JP50944891A JPH05507475A JP H05507475 A JPH05507475 A JP H05507475A JP 91509448 A JP91509448 A JP 91509448A JP 50944891 A JP50944891 A JP 50944891A JP H05507475 A JPH05507475 A JP H05507475A
Authority
JP
Japan
Prior art keywords
aliphatic group
compound according
group
aryl
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP91509448A
Other languages
English (en)
Japanese (ja)
Inventor
デイニーズ，ロバート・エイ
キングスベリー，ウイリアム・デニス
ペンドラク，イスライル
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JPH05507475A publication Critical patent/JPH05507475A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP91509448A 1990-06-07 1991-05-15 ロイコトリエン関連疾患治療用安息香酸誘導体 Pending JPH05507475A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53438890A 1990-06-07 1990-06-07
US534.388 1990-06-07
PCT/US1991/003399 WO1991018880A1 (en) 1990-06-07 1991-05-15 Benzoic acid derivatives for treating leukotriene-related diseases

Publications (1)

Publication Number Publication Date
JPH05507475A true JPH05507475A (ja) 1993-10-28

Family

ID=24129833

Family Applications (1)

Application Number Title Priority Date Filing Date
JP91509448A Pending JPH05507475A (ja) 1990-06-07 1991-05-15 ロイコトリエン関連疾患治療用安息香酸誘導体

Country Status (16)

Country Link
EP (1) EP0532550A1 (de)
JP (1) JPH05507475A (de)
KR (1) KR930700445A (de)
CN (1) CN1058016A (de)
AU (1) AU7901791A (de)
CA (1) CA2083958A1 (de)
FI (1) FI925544A7 (de)
HU (1) HUT64748A (de)
IE (2) IE911912A1 (de)
IL (1) IL98388A0 (de)
MA (1) MA22196A1 (de)
MX (1) MX26142A (de)
PL (1) PL290586A1 (de)
PT (1) PT97912A (de)
WO (1) WO1991018880A1 (de)
ZA (1) ZA914323B (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4226493A (en) * 1992-05-01 1993-11-29 Smithkline Beecham Corporation Leukotriene antagonists
EP0649408A4 (de) 1992-06-30 1995-06-21 Smithkline Beecham Corp Verfahren zum herstellung von phenylthiomethylpyridinylalkenoaten.
IL106156A0 (en) * 1992-06-30 1993-10-20 Smithkline Beecham Corp Pyridinyl compounds
JPH08505148A (ja) * 1992-12-23 1996-06-04 スミスクライン・ビーチャム・コーポレイション ロイコトリエンアンタゴニストとして有用な置換ピリジル化合物
AU1335795A (en) * 1993-12-08 1995-06-27 Smithkline Beecham Corporation Compounds
AU690258B2 (en) * 1994-04-13 1998-04-23 F. Hoffmann-La Roche Ag Substituted pyridine leukotriene B4 antagonists
WO2002076226A1 (fr) * 2001-03-27 2002-10-03 Meiji Seika Kaisha, Ltd. Procede de production d'encas souffles
US7850970B2 (en) 2003-08-26 2010-12-14 The Regents Of The University Of Colorado Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
US8093253B2 (en) 2008-03-06 2012-01-10 Hoffmann-La Roche Inc. Leukotriene B4 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4563446A (en) * 1983-07-27 1986-01-07 Takeda Chemical Industries, Ltd. Thromboxane synthetase inhibiting 3-(1-alkenyl) pyridines
GB8505285D0 (en) * 1985-03-01 1985-04-03 Beecham Group Plc Compounds

Also Published As

Publication number Publication date
FI925544A0 (fi) 1992-12-07
MX26142A (es) 1994-02-28
FI925544L (fi) 1992-12-07
WO1991018880A1 (en) 1991-12-12
AU7901791A (en) 1991-12-31
CA2083958A1 (en) 1991-12-08
PL290586A1 (en) 1992-04-06
PT97912A (pt) 1992-03-31
IE911913A1 (en) 1991-12-18
HUT64748A (en) 1994-02-28
IL98388A0 (en) 1992-07-15
IE911912A1 (en) 1991-12-18
KR930700445A (ko) 1993-03-15
ZA914323B (en) 1992-06-24
EP0532550A1 (de) 1993-03-24
MA22196A1 (fr) 1992-04-01
CN1058016A (zh) 1992-01-22
FI925544A7 (fi) 1992-12-07
HU9203866D0 (en) 1993-03-29

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