JPH06102079B2 - 注射可能な組成物の製造方法 - Google Patents

注射可能な組成物の製造方法

Info

Publication number
JPH06102079B2
JPH06102079B2 JP5-154585A JP15458593A JPH06102079B2 JP H06102079 B2 JPH06102079 B2 JP H06102079B2 JP 15458593 A JP15458593 A JP 15458593A JP H06102079 B2 JPH06102079 B2 JP H06102079B2
Authority
JP
Japan
Prior art keywords
vial
solution
acid
radioactive
iodine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP5-154585A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06197942A (ja
JPH06102079B1 (de
Inventor
ジョン・マーテンス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BE0/212997A external-priority patent/BE899739A/nl
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of JPH06197942A publication Critical patent/JPH06197942A/ja
Publication of JPH06102079B1 publication Critical patent/JPH06102079B1/ja
Publication of JPH06102079B2 publication Critical patent/JPH06102079B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1282—Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B39/00—Halogenation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/58—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
    • C07C63/70—Monocarboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
JP5-154585A 1984-05-24 1985-05-21 注射可能な組成物の製造方法 Expired - Lifetime JPH06102079B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
BE899739 1984-05-24
BE0/212997A BE899739A (nl) 1984-05-24 1984-05-24 Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek.
NL8402138 1984-07-05
NL8402138 1984-07-05
NL899739 1984-07-05

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP60107078A Division JPS6124A (ja) 1984-05-24 1985-05-21 塩素化、臭素化、放射性臭素化、ヨウ素化および／または放射性ヨウ素化芳香族またはヘテロ芳香族化合物およびその製造方法

Publications (3)

Publication Number Publication Date
JPH06197942A JPH06197942A (ja) 1994-07-19
JPH06102079B1 JPH06102079B1 (de) 1994-12-14
JPH06102079B2 true JPH06102079B2 (ja) 1994-12-14

Family

ID=25654100

Family Applications (6)

Application Number Title Priority Date Filing Date
JP5-154585A Expired - Lifetime JPH06102079B2 (ja) 1984-05-24 1985-05-21 注射可能な組成物の製造方法
JP5154584A Expired - Lifetime JP2513573B2 (ja) 1984-05-24 1993-06-02 診断剤組成物
JP5154586A Pending JPH06237999A (ja) 1984-05-24 1993-06-02 器 具
JP5154583A Pending JPH06211698A (ja) 1984-05-24 1993-06-02 造影剤組成物
JP5154588A Pending JPH06199704A (ja) 1984-05-24 1993-06-02 放射性診断剤製造キット
JP5154587A Pending JPH06211700A (ja) 1984-05-24 1993-06-02 温血動物の放射検定法

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP5154584A Expired - Lifetime JP2513573B2 (ja) 1984-05-24 1993-06-02 診断剤組成物
JP5154586A Pending JPH06237999A (ja) 1984-05-24 1993-06-02 器 具
JP5154583A Pending JPH06211698A (ja) 1984-05-24 1993-06-02 造影剤組成物
JP5154588A Pending JPH06199704A (ja) 1984-05-24 1993-06-02 放射性診断剤製造キット
JP5154587A Pending JPH06211700A (ja) 1984-05-24 1993-06-02 温血動物の放射検定法

Country Status (6)

Country Link
US (2) US4942231A (de)
EP (1) EP0165630B1 (de)
JP (6) JPH06102079B2 (de)
AT (1) ATE47315T1 (de)
AU (1) AU576861B2 (de)
DE (1) DE3573725D1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
EP0460118A1 (de) * 1989-03-23 1991-12-11 Mallinckrodt International Corporation Radioaktive mit jod oder brom markierte piperidinverbindung sowie verfahren und zusammensetzung, die diese enthält
US5312592A (en) * 1990-06-13 1994-05-17 Scanditronix Ab Disposable kit for preparation
EP0584256B1 (de) * 1991-04-22 1999-11-10 Mallinckrodt Medical, Inc. Verbindungen und pharmazeutische zusammensetzungen zum nachweis und zur lokalisierung von geweben mit neurokinin-1-rezeptoren
DE69231469T2 (de) * 1991-08-29 2001-01-25 Mallinckrodt Medical, Inc. Verwendung von gentisinsäure oder gentisylalkohol zur stabilisierung von radio-markierten peptiden und proteinen
US5750089A (en) * 1996-01-11 1998-05-12 Neuro Imaging Technologies, Llc Halogenated neuroprobe for mapping monoamine reuptake sites
US5310912A (en) * 1992-02-25 1994-05-10 Research Biochemicals Limited Partnership Iodinated neuroprobe for mapping monoamine reuptake sites
US5698179A (en) * 1992-02-25 1997-12-16 Neuro Imaging Technologies, Llc Iodinated neuroprobe for mapping monoamine reuptake sites
US5342926A (en) * 1993-06-08 1994-08-30 The Regents Of The University Of California Analogs of cytochalasin B as radiopharmaceuticals for nuclear imaging of trans-membrane glucose transport
US5529189A (en) * 1995-08-02 1996-06-25 Daxor Corporation Syringe assembly for quantitative measurement of radioactive injectate and kit having same
AU7164996A (en) * 1995-10-10 1997-04-30 Jimmie L. Johnson Constituent delivery system
US5808146A (en) * 1995-11-09 1998-09-15 Emory University Amino acid analogs for tumor imaging
ES2374743T3 (es) * 1995-12-01 2012-02-21 Molecular Insight Pharmaceuticals, Inc. Estereoisómeros de análogos de ácidos grasos para imagen de diagnóstico.
US5989835A (en) 1997-02-27 1999-11-23 Cellomics, Inc. System for cell-based screening
AU4068299A (en) * 1998-03-30 1999-10-18 Sloan-Kettering Institute For Cancer Research Bismuth-213 generator and uses thereof
IL142765A0 (en) * 1998-11-13 2002-03-10 Cellomics Inc Methods and system for efficient collection and storage of experimental data
US6307045B1 (en) * 1999-07-05 2001-10-23 Sumitomo Chemical Company, Limited Process for producing halogenated benzene compound
JP4161487B2 (ja) * 1999-11-01 2008-10-08 ソニー株式会社 データ復号装置及び方法
CA2396495A1 (en) 2000-01-25 2001-08-02 Cellomics, Inc. Method and system for automated inference creation of physico-chemical interaction knowledge from databases of co-occurrence data
US7514067B2 (en) * 2000-04-25 2009-04-07 President And Fellows Of Harvard College Methods for tumor diagnosis and therapy
JP4615165B2 (ja) * 2001-09-27 2011-01-19 株式会社細川洋行 液体用袋の製造方法
WO2003057214A1 (en) 2001-12-28 2003-07-17 Somatocor Pharmaceuticals, Inc. Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
EP1499584B1 (de) * 2002-04-30 2010-08-18 Emory University Verbindungen zur abbildung von tumoren
USD554764S1 (en) * 2005-03-22 2007-11-06 Gerretz Herbert A Extraction vial
USD554763S1 (en) * 2005-03-22 2007-11-06 Gerretz Herbert A Extraction vial
CA2612187C (en) * 2005-06-23 2013-05-07 Emory University Stereoselective synthesis of amino acid analogs for tumor imaging
AU2006262502A1 (en) * 2005-06-23 2007-01-04 Emory Univerisity Imaging agents
GB0514087D0 (en) * 2005-07-11 2005-08-17 Ge Healthcare Ltd Stabilised radiopharmaceutical compositions
EP1977769A1 (de) * 2007-04-04 2008-10-08 Atomic Energy Council - Institute of Nuclear Energy Research Kit zur Herstellung eines radioaktiven Iod-Markers beinhaltend lyophilisiertes Meta-Iodobenzylguanidin (MIBG), Herstellungsverfahren dafür sowie Methode zur radioaktiven markierung des MIBG.
US8246752B2 (en) 2008-01-25 2012-08-21 Clear Catheter Systems, Inc. Methods and devices to clear obstructions from medical tubes
US9403624B2 (en) * 2009-08-24 2016-08-02 Beekley Corporation Device and method for dispensing a beverage and imaging contrast agent
USD714644S1 (en) * 2012-09-26 2014-10-07 Target Brands, Inc. Bottle

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE720365A (de) * 1967-09-11 1969-02-17
US3814769A (en) * 1969-05-01 1974-06-04 Mallinckrodt Chemical Works Catalyzed radioiodine exchange
US3859429A (en) * 1972-07-07 1975-01-07 Horst Hermann Elias M-iodohippuric acid labelled with radioactive iodine and process for its preparation
US4031198A (en) * 1972-08-30 1977-06-21 Minnesota Mining And Manufacturing Company Technetium-labeled complexes, production and use thereof
US4032625A (en) * 1973-06-11 1977-06-28 Research Corporation Bone-seeking technetium-99m complex
JPS5932457B2 (ja) * 1978-11-29 1984-08-09 エフ・ホフマン−ラ・ロシユ・ウント・コンパニ−・アクチエンゲゼルシヤフト 放射性ヨウ素化アミン
US4298591A (en) * 1979-04-03 1981-11-03 The United States Of America As Represented By The United States Department Of Energy Instantaneous radioiodination of rose bengal at room temperature and a cold kit therefor
EP0071858A1 (de) * 1981-08-06 1983-02-16 Miles Laboratories, Inc. Silierkonservierung mit Propionsäure erzeugenden Mikroorganismen
FR2511870A1 (fr) * 1981-08-28 1983-03-04 Guerbet Sa Procede pour augmenter la tolerance des produits opacifiants, composes utilisables a cet effet et produits opacifiants les contenant
JPS5896031A (ja) * 1981-12-03 1983-06-07 Nippon Mejifuijitsukusu Kk 放射性診断剤およびその製造用組成物
US4942231A (en) * 1984-05-24 1990-07-17 Mallinckrodt, Inc. Method of preparing a chlorinated, brominated, radio-brominated, iodinated and/or radioiodinated aromatic or heteroaromatic compound
BE899739A (nl) * 1984-05-24 1984-11-26 Univ Bruxelles Werkwijze voor het controleren van de substitutie op aromatische kern,en, werkwijze en apparatuur ter bereiding van samenstelling voor scintigrafisch onderzoek.

Also Published As

Publication number Publication date
AU576861B2 (en) 1988-09-08
JPH06197942A (ja) 1994-07-19
JPH06102079B1 (de) 1994-12-14
AU4272785A (en) 1985-11-28
US4942231A (en) 1990-07-17
ATE47315T1 (de) 1989-11-15
US5021220A (en) 1991-06-04
JPH06211699A (ja) 1994-08-02
EP0165630A2 (de) 1985-12-27
JPH06237999A (ja) 1994-08-30
JPH06199704A (ja) 1994-07-19
EP0165630A3 (en) 1986-01-08
JP2513573B2 (ja) 1996-07-03
DE3573725D1 (en) 1989-11-23
JPH06211700A (ja) 1994-08-02
JPH06211698A (ja) 1994-08-02
EP0165630B1 (de) 1989-10-18

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