JPH0612824Y2 - Basket type granulator - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to an apparatus used for granulating a pharmaceutical raw material, in particular, a stirring arm 2, a balance arm 3 and an extrusion blade 4.
The present invention relates to a basket-type granulating device equipped with.

[Problems to be solved by conventional techniques and devices]

When extrusion granulation is performed, a wet basket (powder) that cannot be extruded using a conventional basket type granulator (FIGS. 3 and 4) equipped with a normal presser blade 10, a collar 11 and an extrusion blade 12 is used. Are wet-kneaded with water or an organic solvent, or a solution of a binder dissolved in water or an organic solvent).

In particular, when granulating with a conventional basket type granulator, a wet body made of powder mainly composed of dry powder having a strong shearing force, such as crude drug powder, has a high bulk and is used for the extruding section 8. Because of the small effective amount, the extruding is difficult because the extruding pressure is not sufficiently applied to the wet body. Even if the wet body is easily extruded, the pressing blade 10 forcibly feeds more than necessary wet body to the extruding section 8.
Abnormal pressure is applied to the wet body, resulting in reduced content, reduced activity,
In many cases, inconveniences such as high melting point occur and effective extrusion granulation cannot be performed.

When extruding a wet body made of a powder mainly composed of dry powder having a strong shearing force such as crude drug powder by a conventional basket type granulator, as shown in FIG. Instead, an extruding blade 4 having a shape R having an inscribed circumference on the circumference of the basket 5 is manufactured and attached, and by increasing the effective amount of the wet body to be extruded at the extruding portion 8, a strong extruding pressure is obtained at this portion. As a result, extrusion granulation becomes possible. However, when the extrusion blade 4 and the normal pressing blade 10 are used in combination, an excessive amount of the wet body is forcibly supplied to the extrusion section 8, and when the wet body passes through the extrusion hole 6, it is Abnormal extrusion pressure is applied to the wet body, problems such as clogging of holes caused by strong friction and high frictional heat generated due to it, expansion and destruction of the basket occur frequently, Continuous and effective extrusion granulation is not possible.

In order to eliminate such a trouble in the extruding section 8, it is important to keep the amount of the wet body flowing into the extruding section 8 constant in a well-balanced manner in consideration of the extruding pressure. As one of the measures, the pushing blade 4 shown in FIG.
We attempted extrusion granulation by using the free fall method without attaching the above, but in this case, there was almost no movement of the wet body in the upper or middle part of the basket, and the required amount of wet body continuously dropped into the lower extrusion granulation part. Therefore, extrusion granulation was impossible.

[Means for Solving the Problems]

Therefore, in order to utilize the extrusion vane 4 that produces a strong extrusion pressure, it is necessary to devise a mechanism for continuously supplying an appropriate amount of wet body to the extrusion unit 8. For that purpose, it is best to devise a mechanism to sequentially and quantitatively drop and supply the wet body to the extruding section 8 in a rough state where it is not pressed and compacted from the upper section. In order to achieve the above, we have conducted extensive research and have devised a new granulation mechanism.

That is, as shown in FIG. 1, a stirring arm 2 for constantly stirring the wet body in the upper part of the basket is installed on the upper part of the middle part or the extruding part 8 to the circumferential part of the basket (the upper part of the extruding part 8) as shown in FIG. By attaching the balance arm 3 for lightly collecting the body, the wet body can be quantitatively and continuously supplied from the upper portion to the extruding portion 8 without being pressed and solidified. A method for continuously extruding and granulating from the extrusion hole 6 without devising an excessive pressure on the body has been devised.

The granulating apparatus according to the present invention comprises a stirring arm 2, a balance arm 3, an extruding blade 4 and a cylindrical basket 5 shown in FIG.

Without the stirring arm 2, there is no smooth drop movement of the wet body to the middle or lower part of the basket, which is insufficient.
If there is no extrusion of the wet body to the circumferential portion of the basket by the balance arm 3 that also functions to stir the wet body on the upper portion of the extrusion unit 8, the amount of the wet body required for extrusion to the extrusion unit 8 is continuously supplied. R, which cannot be pushed out and cannot be pushed out, is inscribed in these two arms and the basket circumference shown in FIG.
By using together with the extruding blade 4 having, it becomes possible to continuously extrude and granulate a wet body made of a powder mainly composed of powder having a strong shearing force such as crude drug powder. Is. This reduces the friction generated between the wet bodies when the wet bodies pass through the holes 6 of the basket, makes it easier for the wet bodies to pass through the holes, and reduces the frictional heat generated thereby, thereby extruding. Drying of the wet body in part 8 was eliminated, and continuous extrusion granulation became possible.

〔Example〕

It suffices for the stirring arm 2 to have a function of preventing the bridging phenomenon of the wet body generated in the basket by lightly agitating the wet body inside the basket. Anything can be used as long as it has, and one or more pieces may be used, but it is desirable that the thickness and the width are each 3 mm or more (in FIG. 1, the width is 2a as a column shape).
showed that). Further, the mounting shape may be straight or may have an appropriate bend, and the linear distance 2b from the center of the mounting spindle 1 to the tip of the arm is sufficient for fulfilling the function of stirring the wet body. It is desirable that the radius is ½ or more and 1 or less.

The balance arm 3 is for gently pressing the wet body to the circumference of the basket, which also serves to stir the wet body. Basically, the tip of the balance arm has a shape similar to the circumference of the basket and has an appropriate curvature. For that purpose, the width 3a is 5 mm or more, and the linear distance 3b from the center of the main shaft 1 to be mounted to the re-projection portion of the balance arm 3 (the projection portion closest to the inner circumference of the basket) is the radius of the basket 5. It is preferably ½ or more and 1 or less.

It is preferable that the stirring arm 2 and the balance arm 3 satisfy the above-mentioned condition, but the stirring arm 2 and the balance arm 3 are not necessarily limited thereto, and those similar thereto are all suitable for the purpose.

For the purpose, the width 4a of the extrusion blade 4 is defined by the hole 6 of the extrusion section 8.
6a, and the thickness needs to be 3 mm or more so as to withstand the extrusion pressure. The tip of the extrusion blade 4 is basically inscribed in the circumference of the basket 5, or A similar one (FIG. 2) is preferable, and the tip thereof is preferably cut at a point contacting the inside of the basket 5 or a point slightly shorter than the contact point. In addition, push-out blades 4 so that an excessive push-up pressure is not applied to the wet body.
The bottom of the extrusion blade 4 may be cut in one or several steps as shown in FIG. 5 for the purpose of letting excess wet matter escape from the bottom. The degree of cutting should be determined according to the wet body used for extrusion and is not uniform, and the support 9 is supported on the extrusion blade 4 so that the blade 4 is not bent by the pressure applied to the extrusion blade 4. It is also possible to attach it, or to attach an appropriate protrusion 7 to the extrusion blade 4 in order to enhance the holding effect of the extruded wet body at the extrusion portion 8.

[Effect of action and device]

By using the stirring arm 2, the balance arm 3 and the extruding blade 4 of the present invention, even in the case of a wet body made of dry powder having a strong shearing force such as a powdered crude drug, the diameter of the basket 5 is 0 without swelling. 0.5mm to 1.5
It has become possible to continuously produce cylindrical extruded granules having a diameter of mm, and it has become possible to produce extruded granules containing a powder that is difficult to be extruded as a main component by a basket type granulator.

Further, when extrusion granulation is performed by a normal basket type granulator (FIG. 3), the pressing blade 10 presses the wet body, so that the extruding section 8 exerts an excessive extrusion pressure on the wet body and the activity is reduced. By using the granulating apparatus according to the present invention (Fig. 1), it is possible to extrude and granulate powders that cause inconveniences such as decreasing enzymes and compounds whose melting points change, without causing such problems. It has become possible.

In this way, various problems inherent in the basket-type granulator can be solved because the extruding blade has a shape 4 in which the wet body to be extruded can be easily bited, and the stirring arm 2 and the balance arm 3 are provided. By devising a method of allowing the wet body to be supplied to the extruding section 8 by spontaneous drop supply, a continuous and quantitative amount of the wet body suitable for extrusion can be continuously and quantitatively supplied to the extruding section 8. This is due to the effect of the present invention, which makes it possible to supply by dropping and to extrude a wet body from the hole 6 of the basket by reasonably extruding pressure.

[Brief description of drawings]

FIG. 1 is a drawing showing an embodiment of a basket type granulating apparatus of the present invention, FIG. 2 is a drawing showing a part of an extruding section of the present invention, and FIG. 3 is a conventional basket type granulating apparatus. FIG. 4 is a view showing an embodiment of a granulating device, and FIG. 4 is a view showing a part of an extruding part of a conventional basket type granulating device,
FIG. 5 is a drawing showing an example of the extrusion blade of the present invention. 1: Spindle, 2: Stirring arm, 3: Balance arm, 4:
Extrusion blade, 5: basket, 6: extrusion hole, 7: protrusion, 8: extrusion portion, 9: support, 10: presser blade, 11:
Color, 12: Extrusion blade.

Claims (1)

[Scope of utility model registration request] 1. A main shaft (1) with a stirring arm (2) and a balance arm
(3) and a basket-type granulating device equipped with an extrusion blade (4) inscribed on the circumference of the basket.