JPH0616525A - Hair tonic cosmetic - Google Patents

Abstract

PURPOSE:To obtain a hair tonic cosmetic, capable of promoting peripheral bloodstream of the scalp, activating a hair-matrix cell and excellent in hair growth and preventing effects on alopecia and dandruff by blending an extract of a weeping golden bell known as an antidotal, a drainage, an antiphlogistic and a diuretic agent therein. CONSTITUTION:The hair tonic cosmetic is obtained by blending an extract of a weeping golden bell which is an ingredient extracted from a fruit of Forsythia suspensa Vahl. and Forsythia viridissima Lindl. native to China or Forsythia koreana Nakai native to the Korean Peninsula of the family Oleaceae with an extracting solvent therein. Oleanolic acid which is a triterpenoid, phillyrin, pinoresinol, arctiin, etc., which are lignans, forsythosidae A, etc., which are caffeic acid derivatives are cited as the extracted ingredient. A 10-90% aqueous solution of ethanol is preferred as the extracting solvent. This hair tonic cosmetic can be formulated into a hair tonic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a rinse, a hair gel, a hair mist, a hair foam, etc.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair nourishing cosmetic composition which promotes peripheral blood flow of the scalp and activates hair mother cells, and which is excellent in hair growth effect, hair loss prevention effect, and dandruff prevention effect.

[0002]

2. Description of the Related Art Conventionally, blood circulation promoting substances such as capsicum tincture, nicotinic acid derivatives, etc., or scalp skin cell activating substances such as Senburi extract and Korean carrot extract have been blended. A hair nourishing cosmetic is known. Furthermore, recently, a number of hair nourishing cosmetics have been proposed in which a component having an effect of preventing sebaceous gland hypertrophy and a component having an inhibitory effect on male hormone are mixed.

However, the blood circulation-promoting substances that have been conventionally used have strong skin irritation and have a limited amount to be mixed,
It has a shortcoming that the duration of blood circulation promotion is short. Also, cell activating substances have low permeability to skin at low concentrations,
In addition, there is a problem that the effect cannot be sufficiently exhibited by itself.

On the other hand, androgenetic alopecia is said to be caused by an excessive action of male hormones, but it is a phenomenon such as poor circulation, decreased activity of hair matrix cells, hypertrophy of sebaceous glands, and fibrosis of scalp. It is presumed that is caused by complicated interlocking.

Therefore, the present situation is that even if a male hormone inhibitory component is used, a hair-growth action is not achieved. Furthermore, even if an anti-androgen agent or the like is used as a hair-growing agent in order to suppress the hypertrophy of the sebaceous glands, which is said to be caused by an excessive action of male hormone, the effect is not sufficient.

The Ginkgo biloba extract of the present invention is a substance that has been used as a detoxifier, drainage, anti-inflammatory and diuretic drug. However, it has not been known that the extract of Ginseng has hair growth and hair growth effects. In addition, oral composition (JP-A-63-60918), deodorant (JP-A-63-5754), and deodorant (JP-A-63-21059) are examples of blended extracts of ginseng. However, no application as a hair nourishing cosmetic was found.

Therefore, an object of the present invention is to provide a hair nourishing cosmetic composition which promotes peripheral blood flow of the scalp and activates hair mother cells, and is excellent in hair growth, hair loss prevention, and dandruff prevention effect. .

[0008]

[Means for Solving the Problems] In order to achieve the above-mentioned object, the present inventors have conducted various studies on promotion of peripheral blood flow in the scalp and activation of hair matrix cells, and as a result, nourishment with a ginkgo extract was performed. It was found that hair cosmetics exhibit excellent hair-growth and hair-growth effects.

The ginkgo biloba extract according to the present invention is a component extracted from the fruits of Chinese forsythia, Chinese forsythia, or Korean forsythia, which is native to the Korean Peninsula, of the family Oleaceae. Extracted components include triterpenoid oleanolic acid, lignans phillyrin and pinore.
sinol, arctiin, matairesinol, matairesinoside,
Caffeic acid derivative forsythoside A and the like can be mentioned.
As the extraction solvent, hot water, hydrous alcohol, alcohols, acetone, ethyl acetate, chloroform and the like can be used. Particularly, a 10-90% ethanol aqueous solution is preferable as the extraction solvent.

In the following text, the compounding amount is indicated based on the pure content of the extract obtained by extraction with water or a 50% aqueous solution of ethanol (calculated as the dry residue).

The compounding amount of the ginseng extract of the present invention in the hair nourishing cosmetic composition is 0.001 to 5.0 wt% based on the total amount.
It is sufficient if it is 0.005 to 2.0 wt.
%. That is, if the amount is less than the lower limit, the desired effect of the present invention cannot be sufficiently obtained, and if the amount exceeds the upper limit, it is impossible to expect an improvement in the effect commensurate with the increase.

The hair nourishing cosmetic composition of the present invention can be prepared into a dosage form such as a hairnic, a hair lotion, a hair cream, a hair conditioner, a shampoo, a conditioner, a hair gel, a hair mist, a hair foam, etc. according to a conventional method. is there.

The hair nourishing cosmetic composition of the present invention includes dyes, fragrances, bactericides, antiseptics, keratolytic agents, antiandrogens,
Antioxidants and the like can be appropriately added within a range that achieves the object of the present invention.

[0014]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. In addition,% shown in an Example shows weight%.

The mouse hair growth promoting effect test method, human hair growth promoting effect test method and practical test method described in Examples are shown below.

(1) Test method for mouse hair growth promoting effect: The skin at the center of the back of a ddY white mouse (male, 6 weeks old, average weight: 35 g) was shaved with an electric clipper, and then completely removed with a depilatory cream. From the next day, each sample of the Example and Comparative Example was applied to the skin of the test part twice daily in the morning and evening, 0.2 g per animal.
Applied. For each sample, 10 animals were used per group. The base alone was applied as a control group. On the 15th day after the start of the experiment, the animals were sacrificed, 20 hairs were randomly extracted from the sample application site, each hair length was measured, and the average value of each group was calculated. Next, the value obtained by dividing the average value of the examples or comparative examples by the average value of the control group was used for the determination as the hair growth promoting effect.

(2) Human hair growth promoting effect test method 10 male hair loss patients to be tested were shaving the hair at a position 5 cm above the ears of the head in a circular shape with a diameter of 1 cm at two places on the left and right. About 3 ml of the sample of the Example or Comparative Example was applied to the left side of the test site on the left side twice daily in the morning and evening, and compared with the untreated right side. On the 28th day after the start of the test, 20 hairs on each of the left and right test sites were shaved, and the average value of the lengths of 20 hairs on the left side (applied Example or Comparative Example) (B ) Was divided by the average value (A) of the lengths of 20 hairs on the right side (untreated), and the judgment result was shown by the average value of (B) / (A) of 10 test subjects.

(3) Practical test method 20 heads of male pattern baldness test subjects were evaluated for their effects after applying the sample to the head twice daily in the morning and evening twice continuously for 6 months. The test results show that, for each item of hair-growth effect, hair loss prevention effect, and dandruff prevention effect, "hair bristling or increased hair loss", "less hair loss", "less hair loss" The number of people who answered

Examples 1 to 6 and Comparative Examples 1 to 3 Oily Heartonics In the raw material compositions shown in Table 1, the active ingredients were blended as shown in Table 2 to prepare the haironics, and the above-mentioned various tests were carried out. The capsicum tincture used in Comparative Examples was one listed in the Japanese Pharmacopoeia.

[0020]

[Table 1]

[0021]

[Table 2]

(1) Preparation Method After dissolving the component (B) shown in Table 1 in the component (A) or the component (C), the component (A) and the component (B) are mixed and dispersed by stirring to obtain a container. To fill. At the time of use, the contents should be uniformly dispersed by shaking.

(2) Characteristics The results of various tests of each oily hair artic are shown in the right column of Table 2. As shown in Table 2, Comparative Examples 1 to 3 had a low mouse and human hair growth promoting effect, and the results of the practical tests were also not good. Particularly in Comparative Example 1 in which Capsicum tincture was blended, three people complained of mild skin irritation in a practical test.

On the other hand, the hair nourishing cosmetics of the present invention of Examples 1 to 6 showed a high hair growth promoting effect, and clearly showed good results in all the tests. In addition, Examples 1 to 6 did not cause any skin irritation in various tests on human skin.

Examples 7 to 12 and Comparative Examples 4 to 6 Hair Cream In the raw material composition shown in Table 3, the active ingredients were blended as shown in Table 4 to prepare a hair cream, and various tests were carried out.
The results are shown in the right column of Table 4.

[0026]

[Table 3]

[0027]

[Table 4]

(1) Preparation method After dissolving the component (B) shown in Table 3 in the component (A) or the component (C), the components (A) and (C) are dissolved by heating at 80 ° C. and mixed. did. Further, when cooled to 50 ° C. with stirring, the component (D) was added, and stirring was continued up to 30 ° C. to prepare each hair cream.

(2) Characteristics As shown in Table 4, Examples 7 to 12 showed a high hair growth promoting effect and excellent results in all the tests.

On the other hand, Comparative Examples 4 to 6 were clearly inferior in various characteristics as compared with the hair creams of Examples of the present invention.

[0031]

INDUSTRIAL APPLICABILITY As described above, the present invention improves peripheral blood flow in the scalp, activates hair matrix cells, and is excellent in hair growth effect, hair loss prevention effect, and dandruff prevention effect,
It is obvious to provide a hair nourishing cosmetic composition that is free of skin irritation.

Claims (1)

[Claims] 1. A hair nourishing cosmetic composition comprising an extract of C. japonica.