JPH0635512B2 - 表面変性された基材およびその製法 - Google Patents

表面変性された基材およびその製法

Info

Publication number: JPH0635512B2
Authority: JP; Japan
Prior art keywords: substrate; cationic surfactant; polymeric cationic; dialdehyde; polymeric
Prior art date: 1982-02-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP58018256A

Other languages

English (en)

Japanese (ja)

Other versions

JPS58149915A (ja

Inventor

カ−ル−グスタフ・イヨランデル

ロルフ・ラルソン

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Ird-Biomaterial AB

Original Assignee

Ird-Biomaterial AB

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-09

Filing date

1983-02-08

Publication date

1994-05-11

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=20345951&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JPH0635512(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1983-02-08 Application filed by Ird-Biomaterial AB filed Critical Ird-Biomaterial AB

1983-09-06 Publication of JPS58149915A publication Critical patent/JPS58149915A/ja

1994-05-11 Publication of JPH0635512B2 publication Critical patent/JPH0635512B2/ja

2009-05-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000463 material Substances 0.000 title claims description 18
238000004519 manufacturing process Methods 0.000 title description 8
239000000758 substrate Substances 0.000 claims description 78
239000003093 cationic surfactant Substances 0.000 claims description 65
238000000034 method Methods 0.000 claims description 50
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 30
ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 claims description 28
-1 polytetrafluoroethylene Polymers 0.000 claims description 25
229910052757 nitrogen Inorganic materials 0.000 claims description 20
IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 19
239000004698 Polyethylene Substances 0.000 claims description 18
229920000573 polyethylene Polymers 0.000 claims description 18
SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical group O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 claims description 17
125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims description 14
229920000642 polymer Polymers 0.000 claims description 12
125000003172 aldehyde group Chemical group 0.000 claims description 10
230000004048 modification Effects 0.000 claims description 10
238000012986 modification Methods 0.000 claims description 10
238000011282 treatment Methods 0.000 claims description 10
239000007787 solid Substances 0.000 claims description 9
229920002873 Polyethylenimine Polymers 0.000 claims description 8
239000002798 polar solvent Substances 0.000 claims description 8
125000001302 tertiary amino group Chemical group 0.000 claims description 8
125000004432 carbon atom Chemical group C* 0.000 claims description 7
239000010935 stainless steel Substances 0.000 claims description 7
229910001220 stainless steel Inorganic materials 0.000 claims description 7
239000004800 polyvinyl chloride Substances 0.000 claims description 6
229920000915 polyvinyl chloride Polymers 0.000 claims description 6
239000004094 surface-active agent Substances 0.000 claims description 6
239000011521 glass Substances 0.000 claims description 5
229920002635 polyurethane Polymers 0.000 claims description 5
239000004814 polyurethane Substances 0.000 claims description 5
229920002379 silicone rubber Polymers 0.000 claims description 5
239000004945 silicone rubber Substances 0.000 claims description 5
238000005406 washing Methods 0.000 claims description 5
239000004952 Polyamide Substances 0.000 claims description 4
239000004793 Polystyrene Substances 0.000 claims description 4
229920002647 polyamide Polymers 0.000 claims description 4
229920002223 polystyrene Polymers 0.000 claims description 4
230000008569 process Effects 0.000 claims description 4
229920000098 polyolefin Polymers 0.000 claims description 3
CREXVNNSNOKDHW-UHFFFAOYSA-N azaniumylideneazanide Chemical group N[N] CREXVNNSNOKDHW-UHFFFAOYSA-N 0.000 claims 2
229920001343 polytetrafluoroethylene Polymers 0.000 claims 2
239000004810 polytetrafluoroethylene Substances 0.000 claims 2
150000001413 amino acids Chemical class 0.000 claims 1
239000000203 mixture Substances 0.000 claims 1
239000002861 polymer material Substances 0.000 claims 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 55
229960002897 heparin Drugs 0.000 description 54
229920000669 heparin Polymers 0.000 description 54
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 36
150000001449 anionic compounds Chemical class 0.000 description 35
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 29
239000000243 solution Substances 0.000 description 27
108090000190 Thrombin Proteins 0.000 description 19
229960004072 thrombin Drugs 0.000 description 19
239000000126 substance Substances 0.000 description 18
239000007864 aqueous solution Substances 0.000 description 17
238000001179 sorption measurement Methods 0.000 description 16
239000011780 sodium chloride Substances 0.000 description 15
238000012360 testing method Methods 0.000 description 14
229920002307 Dextran Polymers 0.000 description 13
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 13
150000004676 glycans Chemical class 0.000 description 12
229920001282 polysaccharide Polymers 0.000 description 12
239000005017 polysaccharide Substances 0.000 description 12
229910021653 sulphate ion Inorganic materials 0.000 description 12
239000000872 buffer Substances 0.000 description 11
BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 10
238000010521 absorption reaction Methods 0.000 description 10
238000006243 chemical reaction Methods 0.000 description 9
229920000768 polyamine Polymers 0.000 description 9
239000000047 product Substances 0.000 description 9
125000003277 amino group Chemical group 0.000 description 7
230000000694 effects Effects 0.000 description 7
KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 5
239000003795 chemical substances by application Substances 0.000 description 5
150000001875 compounds Chemical class 0.000 description 5
229920002674 hyaluronan Polymers 0.000 description 5
229960003160 hyaluronic acid Drugs 0.000 description 5
238000011534 incubation Methods 0.000 description 5
239000010410 layer Substances 0.000 description 5
125000000129 anionic group Chemical group 0.000 description 4
230000015572 biosynthetic process Effects 0.000 description 4
238000006664 bond formation reaction Methods 0.000 description 4
239000007853 buffer solution Substances 0.000 description 4
230000008878 coupling Effects 0.000 description 4
238000010168 coupling process Methods 0.000 description 4
238000005859 coupling reaction Methods 0.000 description 4
238000004381 surface treatment Methods 0.000 description 4
ZKHQWZAMYRWXGA-KQYNXXCUSA-J ATP(4-) Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP([O-])(=O)OP([O-])(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O ZKHQWZAMYRWXGA-KQYNXXCUSA-J 0.000 description 3
ZKHQWZAMYRWXGA-UHFFFAOYSA-N Adenosine triphosphate Natural products C1=NC=2C(N)=NC=NC=2N1C1OC(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C(O)C1O ZKHQWZAMYRWXGA-UHFFFAOYSA-N 0.000 description 3
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
206010042674 Swelling Diseases 0.000 description 3
239000004809 Teflon Substances 0.000 description 3
229920006362 Teflon® Polymers 0.000 description 3
230000008901 benefit Effects 0.000 description 3
230000004071 biological effect Effects 0.000 description 3
150000001767 cationic compounds Chemical group 0.000 description 3
125000002091 cationic group Chemical group 0.000 description 3
238000006193 diazotization reaction Methods 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
229920003023 plastic Polymers 0.000 description 3
239000004033 plastic Substances 0.000 description 3
239000011148 porous material Substances 0.000 description 3
238000003756 stirring Methods 0.000 description 3
230000008961 swelling Effects 0.000 description 3
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 2
108010049003 Fibrinogen Proteins 0.000 description 2
102000008946 Fibrinogen Human genes 0.000 description 2
ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 description 2
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
239000004743 Polypropylene Substances 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
239000013543 active substance Substances 0.000 description 2
150000001299 aldehydes Chemical class 0.000 description 2
238000003556 assay Methods 0.000 description 2
239000008280 blood Substances 0.000 description 2
210000004369 blood Anatomy 0.000 description 2
150000001768 cations Chemical group 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
230000002349 favourable effect Effects 0.000 description 2
229940012952 fibrinogen Drugs 0.000 description 2
230000002209 hydrophobic effect Effects 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
150000002500 ions Chemical class 0.000 description 2
230000001453 nonthrombogenic effect Effects 0.000 description 2
229920001155 polypropylene Polymers 0.000 description 2
238000002360 preparation method Methods 0.000 description 2
239000000376 reactant Substances 0.000 description 2
BEOOHQFXGBMRKU-UHFFFAOYSA-N sodium cyanoborohydride Chemical compound [Na+].[B-]C#N BEOOHQFXGBMRKU-UHFFFAOYSA-N 0.000 description 2
LPXPTNMVRIOKMN-UHFFFAOYSA-M sodium nitrite Chemical compound [Na+].[O-]N=O LPXPTNMVRIOKMN-UHFFFAOYSA-M 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
241000283690 Bos taurus Species 0.000 description 1
JQJPBYFTQAANLE-UHFFFAOYSA-N Butyl nitrite Chemical compound CCCCON=O JQJPBYFTQAANLE-UHFFFAOYSA-N 0.000 description 1
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
239000005977 Ethylene Substances 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 description 1
IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 description 1
229920003188 Nylon 3 Polymers 0.000 description 1
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
239000002262 Schiff base Substances 0.000 description 1
150000004753 Schiff bases Chemical class 0.000 description 1
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PCSMJKASWLYICJ-UHFFFAOYSA-N Succinic aldehyde Chemical compound O=CCCC=O PCSMJKASWLYICJ-UHFFFAOYSA-N 0.000 description 1
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239000002253 acid Substances 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
230000009471 action Effects 0.000 description 1
TTWYZDPBDWHJOR-IDIVVRGQSA-L adenosine triphosphate disodium Chemical compound [Na+].[Na+].C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP([O-])([O-])=O)[C@@H](O)[C@H]1O TTWYZDPBDWHJOR-IDIVVRGQSA-L 0.000 description 1
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230000001588 bifunctional effect Effects 0.000 description 1
239000012620 biological material Substances 0.000 description 1
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238000012258 culturing Methods 0.000 description 1
NALBLJLOBICXRH-UHFFFAOYSA-N dinitrogen monohydride Chemical group N=[N] NALBLJLOBICXRH-UHFFFAOYSA-N 0.000 description 1
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230000007613 environmental effect Effects 0.000 description 1
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238000002156 mixing Methods 0.000 description 1
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239000002245 particle Substances 0.000 description 1
230000001766 physiological effect Effects 0.000 description 1
ODGAOXROABLFNM-UHFFFAOYSA-N polynoxylin Chemical compound O=C.NC(N)=O ODGAOXROABLFNM-UHFFFAOYSA-N 0.000 description 1
229910052700 potassium Inorganic materials 0.000 description 1
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239000012286 potassium permanganate Substances 0.000 description 1
239000002244 precipitate Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
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239000002904 solvent Substances 0.000 description 1
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239000012086 standard solution Substances 0.000 description 1
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239000010409 thin film Substances 0.000 description 1
230000002885 thrombogenetic effect Effects 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
230000002792 vascular Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/0005—Use of materials characterised by their function or physical properties
- A61L33/0011—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate
- A61L33/0029—Anticoagulant, e.g. heparin, platelet aggregation inhibitor, fibrinolytic agent, other than enzymes, attached to the substrate using an intermediate layer of polymer
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
- A61L33/02—Use of inorganic materials
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/02—Elements
- C08K3/08—Metals
- C—CHEMISTRY; METALLURGY
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- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/40—Glass
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
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- Y10T428/131—Glass, ceramic, or sintered, fused, fired, or calcined metal oxide or metal carbide containing [e.g., porcelain, brick, cement, etc.]
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10T428/1379—Contains vapor or gas barrier, polymer derived from vinyl chloride or vinylidene chloride, or polymer containing a vinyl alcohol unit
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10T428/1386—Natural or synthetic rubber or rubber-like compound containing
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Hematology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Materials Engineering (AREA)
Public Health (AREA)
Surgery (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Inorganic Chemistry (AREA)
Materials For Medical Uses (AREA)
Treatments Of Macromolecular Shaped Articles (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Phenolic Resins Or Amino Resins (AREA)

JP58018256A 1982-02-09 1983-02-08 表面変性された基材およびその製法 Expired - Lifetime JPH0635512B2 (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE8200750-1		1982-02-09
SE8200750A SE456347B (sv)	1982-02-09	1982-02-09	Ytmodifierat fast substrat samt forfarande for framstellning derav

Publications (2)

Publication Number	Publication Date
JPS58149915A JPS58149915A (ja)	1983-09-06
JPH0635512B2 true JPH0635512B2 (ja)	1994-05-11

Family

ID=20345951

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP58018256A Expired - Lifetime JPH0635512B2 (ja)	1982-02-09	1983-02-08	表面変性された基材およびその製法

Country Status (5)

Country	Link
US (1)	US4565740A (de)
EP (1)	EP0086187B2 (de)
JP (1)	JPH0635512B2 (de)
DE (1)	DE3361044D1 (de)
SE (1)	SE456347B (de)

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1982
- 1982-02-09 SE SE8200750A patent/SE456347B/sv not_active IP Right Cessation
1983
- 1983-02-08 JP JP58018256A patent/JPH0635512B2/ja not_active Expired - Lifetime
- 1983-02-08 DE DE8383850032T patent/DE3361044D1/de not_active Expired
- 1983-02-08 US US06/464,935 patent/US4565740A/en not_active Expired - Lifetime
- 1983-02-08 EP EP83850032A patent/EP0086187B2/de not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP0086187A1 (de)	1983-08-17
EP0086187B1 (de)	1985-10-23
DE3361044D1 (en)	1985-11-28
JPS58149915A (ja)	1983-09-06
SE8200750L (sv)	1983-08-10
US4565740A (en)	1986-01-21
EP0086187B2 (de)	1990-09-26
SE456347B (sv)	1988-09-26

Publication	Publication Date	Title
JPH0635512B2 (ja)	1994-05-11	表面変性された基材およびその製法
KR0143062B1 (ko)	1998-07-15	개질된 표면을 지닌 고체 기재의 제조방법
EP0086186B1 (de)	1986-05-21	Verfahren zur Herstellung von Konjugaten durch kovalente Verbindungen und so hergestellte Produkte
Larm et al.	1983	A new non-thrombogenic surface prepared by selective covalent binding of heparin via a modified reducing terminal residue
US5213898A (en)	1993-05-25	Process for the preparation of surface modified solid substrates
JP4152075B2 (ja)	2008-09-17	表面改質物質を調整する新方法
Yang et al.	2002	Surface modification and blood compatibility of polyacrylonitrile membrane with immobilized chitosan–heparin conjugate
JP4195726B2 (ja)	2008-12-10	非凝血塊形成性ポリマーおよび抗凝血塊形成性ポリマー
US5993890A (en)	1999-11-30	Nonthrombogenic implant surfaces
US5668193A (en)	1997-09-16	Solid substrate coated with an aminopolysaccharide
JPH0140630B2 (de)	1989-08-30
EP0923390B1 (de)	2003-04-23	Verfahren zur herstellung von heparinisierten biomaterialien
EP0124676A1 (de)	1984-11-14	Oberflächlich modifiziertes festes Substrat und Verfahren zu dessen Herstellung
CN102038955B (zh)	2012-04-18	利用傅氏反应接枝制备抗凝血聚砜材料的方法
WO1979000638A1 (en)	1979-09-06	A method of producing thrombosis-resistant surfaces
CN118852512B (zh)	2025-09-16	一种含两性离子、磺酸基和羧基侧链类肝素三元共聚物、涂层、制备方法及应用
CA1340800C (en)	1999-10-26	Articles exhibiting a blood-compatible surface layer and process for providing articles with such a surface layer
JP2000279511A (ja)	2000-10-10	抗血栓性多糖類をコーティングした高分子材料からなる医療用具
JPH0227370B2 (de)	1990-06-15
JPH03188868A (ja)	1991-08-16	医療材料の製造法
AU2317888A (en)	1989-03-31	Articles exhibiting a blood-compatible surface layer and process for providing articles with such a surface layer
JPH11302973A (ja)	1999-11-02	生体適合性に優れたポリビニルアルコール系中空糸およびその製造方法
MXPA97005643A (en)	1998-07-03	Process to modify superfic