JPH06503813A - 抗増殖活性および抗炎症活性を有するモノサッカライド，組成物およびその使用 - Google Patents

抗増殖活性および抗炎症活性を有するモノサッカライド，組成物およびその使用

Info

Publication number
JPH06503813A
JPH06503813A JP3515897A JP51589791A JPH06503813A JP H06503813 A JPH06503813 A JP H06503813A JP 3515897 A JP3515897 A JP 3515897A JP 51589791 A JP51589791 A JP 51589791A JP H06503813 A JPH06503813 A JP H06503813A
Authority
JP
Japan
Prior art keywords
isopropylidene
glucofuranose
deoxy
methyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP3515897A
Other languages
English (en)
Japanese (ja)
Inventor
アロラ，サダーシャン，ケイ．
ウィストラー，ロイ，エル．
トーマス，アルバート，ブイ．
Original Assignee
グリニッチ　ファーマスューティカル，インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by グリニッチ　ファーマスューティカル，インコーポレイテッド filed Critical グリニッチ　ファーマスューティカル，インコーポレイテッド
Publication of JPH06503813A publication Critical patent/JPH06503813A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C07H15/10—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical containing unsaturated carbon-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/18—Acyclic radicals, substituted by carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP3515897A 1990-09-12 1991-09-12 抗増殖活性および抗炎症活性を有するモノサッカライド，組成物およびその使用 Pending JPH06503813A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58154290A 1990-09-12 1990-09-12
US581,542 1990-09-12
US75781791A 1991-09-11 1991-09-11
PCT/US1991/006458 WO1992004359A2 (fr) 1990-09-12 1991-09-12 Monosaccharides presentant une activite anti-proliferative et anti-inflammatoire, compositions et leurs utilisations

Publications (1)

Publication Number Publication Date
JPH06503813A true JPH06503813A (ja) 1994-04-28

Family

ID=27078356

Family Applications (1)

Application Number Title Priority Date Filing Date
JP3515897A Pending JPH06503813A (ja) 1990-09-12 1991-09-12 抗増殖活性および抗炎症活性を有するモノサッカライド，組成物およびその使用

Country Status (7)

Country Link
EP (1) EP0548226A1 (fr)
JP (1) JPH06503813A (fr)
AU (1) AU8622991A (fr)
CA (1) CA2091587A1 (fr)
IE (1) IE913228A1 (fr)
IL (1) IL99454A0 (fr)
WO (1) WO1992004359A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025057872A1 (fr) * 2023-09-13 2025-03-20 学校法人藤田学園 Promoteur d'induction de lymphocytes t régulateurs, agent thérapeutique ou prophylactique pour maladie auto-immune, agent thérapeutique ou prophylactique pour maladie allergique, composition alimentaire pour prévenir une maladie auto-immune, composition alimentaire pour prévenir une maladie allergique, composition alimentaire pour améliorer l'état allergique, composition alimentaire pour maintenir une fonction immunitaire saine, méthode de traitement ou de prévention d'une maladie auto-immune ou d'une maladie allergique, et méthode de criblage d'une substance capable de favoriser l'induction d'un lymphocyte t régulateur

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360792A (en) * 1991-12-20 1994-11-01 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom
FR2694753B1 (fr) * 1992-07-09 1994-12-23 Picardie Jules Verne Universit Procédés de synthèse spécifique de nouveaux aminothioéthers par substitution des sites hydroxylés sur des molécules mono ou polyhydroxylées, produits obtenus par ces procédés et leurs applications.
US5432163A (en) * 1992-11-13 1995-07-11 Greenwich Pharmaceuticals Incorporated Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
JPH09501148A (ja) * 1993-06-11 1997-02-04 ボストン ライフ サイエンシィズ，インコーポレイテッド 免疫調節性、抗炎症性および抗増殖性化合物：イドースの５，６−ジデオキシ，５−アミノ誘導体およびグルコースの６−デオキシ，６−アミノ誘導体
WO2006111783A1 (fr) * 2005-04-19 2006-10-26 Ranbaxy Laboratories Limited Derives de monosaccharides utiles comme agents anti-inflammatoires et/ou anticancereux
EP1842855A3 (fr) * 2006-03-29 2007-12-05 Ranbaxy Laboratories Limited Dérivés de monosaccharide en tant qu'agnets antiinflammaotoires et/ou agents anticancéreux
EP1864992A2 (fr) 2006-05-30 2007-12-12 Ranbaxy Laboratories, Ltd. Dérivés de monosaccharide
US20080300196A1 (en) * 2006-10-03 2008-12-04 Ashwani Kumar Verma Monosaccharide derivatives

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1589916A (en) * 1976-11-16 1981-05-20 Prodotti Antibiotici Spa Glucofuranose derivatives
JPS55154991A (en) * 1979-05-23 1980-12-02 Hisamitsu Pharmaceut Co Inc Beta-d-fructopyranoside derivative
US4735934A (en) * 1981-02-17 1988-04-05 Greenwich Pharmaceuticals Incorporated Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
US4996195A (en) * 1989-01-09 1991-02-26 Greenwich Pharmaceuticals Inc. Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives
US5010058A (en) * 1989-06-22 1991-04-23 501 Greenwich Pharmaceuticals Incorporated 3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025057872A1 (fr) * 2023-09-13 2025-03-20 学校法人藤田学園 Promoteur d'induction de lymphocytes t régulateurs, agent thérapeutique ou prophylactique pour maladie auto-immune, agent thérapeutique ou prophylactique pour maladie allergique, composition alimentaire pour prévenir une maladie auto-immune, composition alimentaire pour prévenir une maladie allergique, composition alimentaire pour améliorer l'état allergique, composition alimentaire pour maintenir une fonction immunitaire saine, méthode de traitement ou de prévention d'une maladie auto-immune ou d'une maladie allergique, et méthode de criblage d'une substance capable de favoriser l'induction d'un lymphocyte t régulateur

Also Published As

Publication number Publication date
IL99454A0 (en) 1992-08-18
CA2091587A1 (fr) 1992-03-13
IE913228A1 (en) 1992-02-25
AU8622991A (en) 1992-03-30
WO1992004359A2 (fr) 1992-03-19
EP0548226A1 (fr) 1993-06-30
WO1992004359A3 (fr) 1992-12-10

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