JPH06505975A - 環状リガンド - Google Patents

環状リガンド

Info

Publication number
JPH06505975A
JPH06505975A JP4506056A JP50605692A JPH06505975A JP H06505975 A JPH06505975 A JP H06505975A JP 4506056 A JP4506056 A JP 4506056A JP 50605692 A JP50605692 A JP 50605692A JP H06505975 A JPH06505975 A JP H06505975A
Authority
JP
Japan
Prior art keywords
ligand
tables
formulas
ligand according
chemical formulas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP4506056A
Other languages
English (en)
Japanese (ja)
Inventor
ブロワー、フィリップ・ジョン
リチャードソン、エイドリアン・ピーター
スミス、レイモンド・ジョン
Original Assignee
ブリティッシュ・テクノロジー・グループ・リミテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919105898A external-priority patent/GB9105898D0/en
Priority claimed from GB919125882A external-priority patent/GB9125882D0/en
Application filed by ブリティッシュ・テクノロジー・グループ・リミテッド filed Critical ブリティッシュ・テクノロジー・グループ・リミテッド
Publication of JPH06505975A publication Critical patent/JPH06505975A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D341/00—Heterocyclic compounds containing rings having three or more sulfur atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6578—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP4506056A 1991-03-20 1992-03-19 環状リガンド Pending JPH06505975A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9105898.2 1991-03-20
GB919105898A GB9105898D0 (en) 1991-03-20 1991-03-20 Compounds useful as intermediates for binding ions to substrates
GB9125882.2 1991-12-05
GB919125882A GB9125882D0 (en) 1991-12-05 1991-12-05 Cyclic ligands
PCT/GB1992/000492 WO1992016520A1 (fr) 1991-03-20 1992-03-19 Ligands macrocycliques de thioether et leur utilisation en tant qu'intermediaires pour lier les ions aux substrats

Publications (1)

Publication Number Publication Date
JPH06505975A true JPH06505975A (ja) 1994-07-07

Family

ID=26298609

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4506056A Pending JPH06505975A (ja) 1991-03-20 1992-03-19 環状リガンド

Country Status (5)

Country Link
EP (1) EP0576492A1 (fr)
JP (1) JPH06505975A (fr)
CA (1) CA2105872A1 (fr)
GB (1) GB2253850B (fr)
WO (1) WO1992016520A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
EP1015428B1 (fr) * 1997-09-18 2003-05-02 Pierce Chemical Company Sulfo-n-hydroxysuccinimide et procede d'elaboration
US5892057A (en) 1997-09-18 1999-04-06 Pierce Chemical Company Preparation of sulfo-N-hydroxysuccinimide salts
US20210228748A1 (en) * 2017-02-08 2021-07-29 Helmholtz-Zentrum Dresden - Rossendorf E.V. In vivo stable hg-197(m) compounds, method for the production thereof and use thereof in nuclear medical diagnostics and endoradionuclide therapy (theranostics)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782013A (en) * 1987-07-23 1988-11-01 Eastman Kodak Company Photographic element containing a macrocyclic ether compound

Also Published As

Publication number Publication date
GB2253850B (en) 1994-11-09
CA2105872A1 (fr) 1992-09-21
EP0576492A1 (fr) 1994-01-05
WO1992016520A1 (fr) 1992-10-01
GB2253850A (en) 1992-09-23
GB9205992D0 (en) 1992-04-29

Similar Documents

Publication Publication Date Title
US5183653A (en) Boronic acid adducts of metal dioxime complexes useful in labelling proteins and other amine-containing compounds
US5350837A (en) Complexes with 99m Tc suitable for radiolabelling monoclonal antibodies or other macro molecules
US4732974A (en) Metal ion labeling of carrier molecules
DE69126124T2 (de) Polymere träger zur freisetzung kovalent gebundener wirkstoffe
DE3650172T2 (de) Diphosphonatderivierte Makromoleküle.
US5601800A (en) New multifunctional ligands for potential use in the design therapeutic or diagnostic radiopharmaceutical imaging agents
JPH03504976A (ja) 骨造影及び骨癌療法のための接合体
JP3097755B2 (ja) 遷移金属の窒化物錯体の製造方法
US5219555A (en) Method for labeling proteins with technetium or rhenium
US5196515A (en) Thiolactone bifunctional chelating agents for diagnostic and therapeutic products
HUT73665A (en) Bifunctional-chelating agents braked with calcogene atoms, pharmaceutical compositions containing them , and use of these compositions in radio- diagnosis and radiotherapy
JPH06505975A (ja) 環状リガンド
Najafi et al. Synthesis and preliminary evaluation of a new chelate N2S4 for use in labeling proteins with metallic radionuclides
Gniazdowska et al. Synthesis, radiochemistry and stability of the conjugates of technetium-99m complexes with Substance P
Xu et al. Synthesis and evaluation of hydroxamamide-based tetradentate ligands as a new class of thiol-free chelating molecules for 99mTc radiopharmaceuticals
Papadopoulos et al. Synthesis and characterization of five-coordinate rhenium (V) and technetium (V) mixed ligand bifunctional complexes carrying the SNS/S or the SNN/S donor atom set. Crystal structure of ReO {[(C2H5) 2NCH2CH2N (CH2CH2S) 2](p-H2N–PhS)} and ReO {[(CH2) 4NCH2CH2NCH2CH2S](p-H2N–PhS)}
JP2020504103A (ja) テクネチウム系化合物により高感受性及び感熱性の標的指向性生体分子を標識化する方法
McPherson et al. Radiolabeling of proteins with radioisotopes of copper using p‐carboxyalkylphenylglyoxal bis‐(4N‐methylthiosemicarbazone)(TSC) bifunctional chelates
Babich et al. 6-Mercaptomethylpyridine-3-carboxylic acid (MEMNIC): a new reagent for peptide labeling with Tc-99m
US6143275A (en) Type S3 N2 chelators for radioactive isotopes, their metal complexes and their diagnostic and therapeutical use
US20100324319A1 (en) Tame based chelators and uses thereof
Leenhardt et al. TrisOxine abiotic siderophores for technetium complexation: radiolabeling and biodistribution studies
Boll et al. Vallabhajosula S, Babich JW. Nucl Med Biol. 2017; 55: 38-46.
Selivanova Technetium-99M Complexes with 2-pyrollylthiones: A New Class of Radiopharmaceuticals for Medical Imaging
GB2214507A (en) 2,3-dithiosuccinic acid derivative and their use