JPH06510545A - 化合物 - Google Patents

化合物

Info

Publication number
JPH06510545A
JPH06510545A JP5505509A JP50550993A JPH06510545A JP H06510545 A JPH06510545 A JP H06510545A JP 5505509 A JP5505509 A JP 5505509A JP 50550993 A JP50550993 A JP 50550993A JP H06510545 A JPH06510545 A JP H06510545A
Authority
JP
Japan
Prior art keywords
chloro
methyl
tetrahydro
benzazepine
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5505509A
Other languages
English (en)
Japanese (ja)
Inventor
デマリニス，ロバート・マイケル
フェイファー，フランシス・リチャード
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JPH06510545A publication Critical patent/JPH06510545A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
JP5505509A 1991-09-12 1992-09-11 化合物 Pending JPH06510545A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919119467A GB9119467D0 (en) 1991-09-12 1991-09-12 Chemical compounds
GB9119467,0 1991-09-12
PCT/US1992/007694 WO1993004686A1 (fr) 1991-09-12 1992-09-11 Composes chimiques

Publications (1)

Publication Number Publication Date
JPH06510545A true JPH06510545A (ja) 1994-11-24

Family

ID=10701273

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5505509A Pending JPH06510545A (ja) 1991-09-12 1992-09-11 化合物

Country Status (5)

Country Link
EP (1) EP0603314A4 (fr)
JP (1) JPH06510545A (fr)
AU (1) AU2654792A (fr)
GB (1) GB9119467D0 (fr)
WO (1) WO1993004686A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009507037A (ja) * 2005-09-01 2009-02-19 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体アゴニストとしての６−置換された２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン
JP2009507038A (ja) * 2005-09-01 2009-02-19 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体アゴニストとしての６−Ｎ結合型へテロ環置換された２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン
JP2009508818A (ja) * 2005-09-01 2009-03-05 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体アゴニストとしての６−置換−２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン
JP4796047B2 (ja) * 2004-02-25 2011-10-19 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体作用薬としての６−置換２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999007353A1 (fr) * 1997-08-05 1999-02-18 The Mount Sinai School Of Medicine Of The City University Of New York UTILISATION D'ANTAGONISTES DE RECEPTEUR α1A-ADRENERGIQUE DANS LA THERAPIE DU GLAUCOME
BR9916162A (pt) * 1998-12-14 2001-09-04 Cellegy Pharma Inc Composição e método para o tratamento de um distúrbio anorretal e para controlar a dor associada com o mesmo
WO2003042190A1 (fr) 2001-11-12 2003-05-22 Pfizer Products Inc. Derives de n-adamantylalkyle benzamide en tant qu'antagonistes du recepteur p2x7
PA8557501A1 (es) 2001-11-12 2003-06-30 Pfizer Prod Inc Benzamida, heteroarilamida y amidas inversas
KR100897642B1 (ko) 2002-12-20 2009-05-14 글락소 그룹 리미티드 신경 장애 치료용 벤즈아제핀 유도체
PA8591801A1 (es) 2002-12-31 2004-07-26 Pfizer Prod Inc Inhibidores benzamidicos del receptor p2x7.
US7071223B1 (en) 2002-12-31 2006-07-04 Pfizer, Inc. Benzamide inhibitors of the P2X7 receptor
ATE355273T1 (de) 2003-05-12 2006-03-15 Pfizer Prod Inc Benzamidinhibitoren des p2x7-rezeptors
AU2004283452A1 (en) * 2003-10-23 2005-05-06 F. Hoffmann-La Roche Ag Benzazepine derivatives as MAO-B inhibitors
WO2006003500A1 (fr) 2004-06-29 2006-01-12 Pfizer Products Inc. Procedes permettant de preparer des derives de 5-[4-(2-hydroxy-propyl)-3,5-dioxo-4,5-dihydro-3h-[1,2,4]triazin-2-yl]-benzamides par deprotection des precurseurs proteges par hydroxyle
AU2006287202B2 (en) 2005-09-01 2013-01-24 Eli Lilly And Company 6-arylalkylamino- 2,3,4,5-tetrahydro-1H-benzo[d]azepines as 5-HT2c receptor agonists

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3483185A (en) * 1966-08-16 1969-12-09 American Home Prod N-substituted 2,3,4,5-tetrahydro-1h-3-benzazepines
ZA792785B (en) * 1978-07-07 1980-08-27 Smithkline Corp Mercapto substituted-2,3,4,5-tetrahydro-1h-3-benzazepines
US4469634A (en) * 1982-07-29 1984-09-04 Smithkline Beckman Corporation Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4683229A (en) * 1986-03-17 1987-07-28 Smithkline Beckman Corporation 6-halo-9-alkenyleneoxy-3-alkyl-2,3,4,5-tetrahydro-(1H-3)-benzazepines and their use as selective alpha-adrenergic receptor antagonists
EP0285287A3 (fr) * 1987-03-23 1990-08-16 Smithkline Beecham Corporation Emploi de 3-benzazépines pour le traitement des troubles de la mobilité gastro-intestinale

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4796047B2 (ja) * 2004-02-25 2011-10-19 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体作用薬としての６−置換２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン
JP2009507037A (ja) * 2005-09-01 2009-02-19 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体アゴニストとしての６−置換された２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン
JP2009507038A (ja) * 2005-09-01 2009-02-19 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体アゴニストとしての６−Ｎ結合型へテロ環置換された２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン
JP2009508818A (ja) * 2005-09-01 2009-03-05 イーライ リリー アンド カンパニー ５−ＨＴ２Ｃ受容体アゴニストとしての６−置換−２，３，４，５−テトラヒドロ−１Ｈ−ベンゾ［ｄ］アゼピン

Also Published As

Publication number Publication date
GB9119467D0 (en) 1991-10-23
AU2654792A (en) 1993-04-05
EP0603314A1 (fr) 1994-06-29
WO1993004686A1 (fr) 1993-03-18
EP0603314A4 (en) 1994-08-24

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