JPH0717846A - Topical skin - Google Patents

Abstract

(57) [Summary] [Objective] To provide a skin external preparation in which a specific plant extract is used in combination with kojic acid and / or a derivative thereof to synergistically enhance the skin whitening effect and enhance the anti-inflammatory effect. [Composition] Kojic acid and / or a derivative thereof, and Echinacea, Odorichosou, Veronica, Chrysalis, Goatweed, Primrose, Shimotake, Peony, Shobu, Taiso, Spruce, Dwarf pine, Dokudami,
An external preparation for skin, which comprises one or more kinds of plant extracts selected from the group consisting of nazna, parsley, harimokushuku, loquat leaf, peach leaf, mugwort, ladies' mantle, rosemary, and waremoko.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin external preparation excellent in fairness and anti-inflammatory action, and more specifically, it is prepared by using a specific plant extract in combination with kojic acid and / or its derivative. The present invention relates to an external preparation for skin that synergistically enhances a whitening effect and an anti-inflammatory effect.

[0002]

2. Description of the Related Art It is known that spots such as spots and freckles appearing on human skin are mainly caused by deposition of Eumelanin. Various kinds of cosmetics have been studied for a long time in order to suppress the production of melanin, which causes such spots and freckles, and to lighten the skin as a whole. For example, hydrogen peroxide and peroxides such as zinc perborate have been tried to be added to cosmetics, and vitamin C, cysteine, colloidal sulfur and the like have been added to cosmetics. However, none of them has been satisfactory in terms of preservability and whitening effect.

The present inventors have been conducting research for many years on an external preparation for removing spots such as spots and freckles appearing on human skin and increasing the skin-whitening effect of the entire skin. Factors related to skin color include melanin, carotene amount, blood flow (oxidized and reduced hemoglobin), skin thickness and transparency, and light is reflected, absorbed and scattered by these factors to change skin color. However, among these, it has been clarified that melanin, especially brown or black eumelanin, is the main cause of pigmentation, and we have sought a substance that suppresses the production of melanin.

In the study, it was found that kojic acid (5-oxy-2-oxymethyl-γ-pyrone) and its derivatives have an extremely excellent melanin production inhibitory action, and a fair-white makeup containing them as an active ingredient. Have invented a chemical and an external preparation and have provided them to the market (Japanese Patent Publication No. 56).
-18569, JP-A-54-92632,
JP-A-56-79616, JP-A-56-7727
No. 2, JP-A-56-7776, JP-A-56-
7710, JP-A-56-20330, JP-B-63-24968).

These light-whitening cosmetics and external preparations are used in commercial forms such as creams, lotions, emulsions, packs, lotions, ointments and poultices, all of which suppress excellent melanin production, It is used as a cosmetic or external preparation that produces a whitening effect. Also, to prevent pigmentation of stains and freckles from being promoted by ultraviolet rays,
An ultraviolet absorber was appropriately blended with the cosmetic or external preparation. However, when exposed to ultraviolet rays for a long time,
Since the skin is injured, inflamed, and painful in use,
It has been desired to develop a whitening external preparation having an excellent anti-inflammatory effect. Kojic acid is known as an ideal skin-whitening agent that also has an anti-inflammatory effect (Japanese Patent Publication No. 58-34446), but it is not always sufficient as an effect of improving severe skin inflammation. .

[0006]

DISCLOSURE OF THE INVENTION The present inventors have conducted extensive studies to improve the above-mentioned drawbacks of the prior art, and as a result, in the skin external preparation containing kojic acid and / or kojic acid derivative,
The present invention has been completed based on the finding that not only an excellent anti-inflammatory effect can be obtained by the synergistic action of the two when a specific plant extract is used in combination, but also a whitening effect can be obtained.

[0007]

Means for Solving the Problems That is, the present invention relates to kojic acid and / or a derivative thereof, and Chinese cabbage, Odorichosou, kumatsudura, black pepper, goatweed, primrose, spirea, peony, shabu, tannin, spruce, dwarf pine. , Dokudami, nazuna, parsley,
A skin external preparation excellent in anti-inflammatory action and whitening action, containing one or more kinds of plant extracts selected from the group consisting of Harimoksuk, loquat leaf, peach leaf, mugwort, ladies' mantle, rosemary, and oleander. is there.

[0008]

DETAILED DESCRIPTION OF THE INVENTION As kojic acid (5-oxy-2-oxymethyl-γ-pyrone) used in the present invention, a pure product of 5-oxy-2-oxymethyl-γ-pyrone, koji A fermentation broth containing kojic acid as a main component obtained by culturing a known strain having an acid-producing ability, a concentrated solution of the fermentation broth, and a crystallized extract of kojic acid from the fermentation broth are used. It

As the kojic acid derivative, for example, Japanese Patent Publication No. 60-10005, Japanese Patent Publication No. 1-45472, Japanese Patent Publication No. 3-74229, and Japanese Patent Publication No. 58-22151.
And an esterification product of kojic acid and -CH ₂ O at the 2-position of kojic acid disclosed in JP-B-58-22152.
Known compounds such as a kojic acid derivative in which a kojic acid molecule is stabilized by binding a saccharide to the H group can be used alone or in combination of two or more kinds.

Specific examples of plant extracts used in combination with kojic acid and / or acid derivatives thereof include the following.

Echinaceae pallida is a plant that grows in North America and Russia and grows to 30 to 120 cm. It has thin stems, lanceolate leaves and peripheral flowers.
As the extract (Echinacea Extract), the one extracted from rhizome can be preferably used.

Odorikosou (Lamium album L.) is a perennial that grows naturally throughout Japan, in Karafuto, Korea, and in the mountains of China. As the extract (White Nettle Extract), purified water, ethanol, propylene glycol, 1,
Those extracted with 3-butylene glycol or a mixture thereof, and those extracted with a propylene glycol solution of stems, leaves and flowers can be preferably used, and as its oil-soluble white nettle extract, Those obtained by extracting flowers with persic oil, liquid paraffin, or a mixed solution thereof can be preferably used.

Verbena officinalis is
Weeds found at the boundaries of hedges and forest areas, and also grow on walls. The petioles are rough and square with small, red or pale blue flowers. The extract (Verbena Extract)
As the leaf extract, a leaf extract can be preferably used.

Brassica nigra is a first-year plant originating in Asia, but is currently cultivated all over the world. At a height of 3 m, the leaves have dentate projections throughout and are lanceolate above the petiole. The flowers are yellow and large and gather in the cluster. The fruits are pods with black spherical seeds. The extract (Blac
As k Mustard Extract), a fruit extract can be preferably used.

Goat Weed (Aegopodii podagrariae
) Is a common plant in Europe and Asia,
It is a plant of the Umbelliferae family that grows to a height of 50 to 100 cm. Hollow stem, elliptical tapering leaves with jagged green leaves,
Has white or pink flowers. The extract (Goat Weed
As Extract), those extracted from leaves can be preferably used.

Primula is a small plant with oval-shaped soft leaves. The origins are in England and Northern Europe. It grows in grasslands, hills, and forests, and blooms yellow-shaped yellow flowers in April to May. The extract (Pr
As the imula Extract), a flower extract can be preferably used.

As the spirea extract, Spiraea ulmaria (Rosaceae: Rosaceae)
) Hanabe from propylene glycol solution or 1,3
-The extract obtained by extraction with butylene glycol can be preferably used.

Peony Root Extract
As for the peony (Paeonia lactiflora Pallas (P
aeonia albiflora var.trichocarpa Bunge)) or other green plant (Paeoniaceae: Botanidae)) from the fine powder of the root, ethanol, 1,3-butylene glycol, produced water or an extract extracted with a mixture thereof is preferably used. it can.

[0019] Shobu (Acorus calamus) is a plant native to wetlands in Asia and North America, which has branched rhizomes and a thickness of about 3 cm. The leaves are shaped like swords, with small greenish flowers. An extract from the root can be preferably used as the Clamus root extract.

[0020] The seaweed is jujuba Miju (Zizyphus jujuba Mi
ller var.inermis Rehder) or its near-green plant fruit. Jujube is a deciduous small Takagi tree native to Southern Europe and cultivated in various parts of Japan. Jujube means summer buds, and this name is given to the buds in early summer. As the extract (Jujube Extract), ethanol, 1,
An extract extracted with 3-butylene glycol, purified water or the like can be preferably used.

[0021] Spruce (orange skin) is the Citrus a
Urantium L.var.daidai Makino) is a mature pericarp. Daidai is an Indian evergreen citrus tree that is native to India and is cultivated in warm regions. Orange peel is an aromatic stomachic,
It is used as an herbal medicine for indigestion and loss of appetite.
As spruce extract (Bitter Orange Peel Extract), spruce is water, ethanol, propylene glycol,
An extract obtained by extracting with 1,3-butylene glycol or the like can be preferably used.

Dwarf pine is a kind of pine having a total length of 6 m or less, and as the extract (Dwarf Pine Extract), an extract of needle-shaped leaves (Pinepumilionis) can be preferably used.

Houttuynis cordata Thunberg
) Is a perennial herb that grows naturally in the mountains, wilderness, and roadside wetlands. As the extract (Houttuynia Extract), those obtained by extracting leaves and stems with ethanol, 1,3-butylene glycol, purified water and the like can be preferably used.

Nazna (Capsella bursapastoris), also known as Penpengusa, is a two-year herb that grows in the fields, wilderness and roadsides, and has a stem that grows to a height of 15 to 50 cm. The leaf edge has jagged leaves from the root, 1
Bear fruit all year round. The extract (Shepherds Purse Extrac
As t), leaves extracted with purified water can be preferably used.

[0025] Parsley (Petroselinum sativum), also known as Dutch aeri, is a second-year herbaceous plant of the Apiaceae,
Although it grows naturally, it is widely cultivated. The extract (Pars
leyExtract) is obtained by extracting leaves with purified water, 1,3-butylene glycol or the like, or by extracting from the root with a mixture of propylene glycol, polyoxyethylene (20) sorbitan monolaurate and purified water. The extract can be preferably used.

Harimoksuk (Oononis spinosa) is
It is a plant 30 to 60 cm tall and normally grows on arid pastures in Central, Eastern Europe and Asia.
The main root is strong and deeply rooted in the soil. The petioles are covered with hair and have many thorns. The leaves are single at the tip and 3 at the bottom.
It is feather-shaped with two saw-shaped leaflets. The flowers are pink or rosy. The extract (Restharrow E
As the xtract, those extracted from the root can be preferably used.

Loquat (Eriobotrya japonica Lindl.) Is an evergreen cypress tree of the family Rosaceae, which grows and grows naturally in the warm regions of Japan. It was once used as a refreshing and stomachic agent in hot weather and as a preventive agent. As a bath agent, it is said to be good for smoothing the skin and for heat rash. As loquat leaf extract, purified water from leaves,
An extract obtained by extraction with 1,3-butylene glycol, ethanol or the like can be preferably used. Further, as the oil-soluble loquat leaf extract, an extract obtained by extracting ethanol from leaves or an extract obtained by concentrating the extract and culturing with squalane can be preferably used.

Peach (Prunus persica Batch) is a deciduous tree of the Rosaceae native to China and cultivated in various places. Peach leaf extract is peach or peach (Prunus persica Batch var. Davidiara Maximowi
ch) leaves extracted with ethanol, 1,3-butylene glycol or the like, or those extracted with purified water and added with concentrated glycerin can be suitably used. Also,
Oil-soluble peach leaf extract
As the extract, an extract obtained by extracting peach leaves with absolute ethanol and extracted and dissolved with squalane can be preferably used.

Mugwort (Artemisia princeps Pamp.) Is
A perennial plant of the Asteraceae family, the extract of which can be suitably used as the extract.

[Ladies' mantle (Achemilla vulgari
s) is a perennial plant found in North America and throughout Europe. The stems are 10 to 15 cm long and small yellow-green flowers bloom. The extract (Lady's Mantle Ex
As the tract), a leaf extract can be preferably used.

Rosemary (Rosemarinus officinalis
L.) is also known as Mannenrou, and is an evergreen shrub of the Lamiaceae family, which grows naturally along the Mediterranean coast and is cultivated in many parts of the world, including central Europe. It has a unique fragrance.
As the Rosemary Extract, leaves or flowers are purified water, ethanol, propylene glycol, 1,
Those obtained by extraction with 3-butylene glycol and the like can be suitably used. In Europe, it is a folk medicine for a long time as a tonic, stimulant, carminative, and for the treatment of indigestion, stomach pain and nerve fatigue. Was being taken internally. It was also used as a mouthwash, cleaning solution, and bath agent. Further, as the oil-soluble extract, those obtained by extracting from leaves with perlic oil, liquid paraffin, sunflower oil, squalane, etc. can be preferably used.

Sanguisorbae officinalis
L.) is a perennial plant of the family Asteraceae and is a plant that grows naturally in the mountains. The root of Waremoko is called Chiku, and is used as a hemostatic and astringent drug. As the extract (Burnet Extract), an extract obtained by extracting with purified water, ethanol, 1,3-butylene glycol or the like from roots and rhizomes of Waremoko and its varieties can be preferably used.

In the present invention, the compounding amount of the kojic acid and / or its derivative and the plant extract exemplified above is
In the case of cosmetics such as creams, lotions, emulsions, packs, lotions, and essences, and when used as external preparations such as ointments, poultices, plasters, etc. Is 0.0001
To 20% by weight, preferably 0.01 to 10% by weight, and kojic acid and / or its derivatives in an amount of 0.001 to 10% by weight, preferably 0.1 to 5% by weight.

The external preparation for skin of the present invention is not particularly limited as long as it is suitable for external application, and as mentioned above, for example, poultice, plaster, paste, cream, ointment, aerosol, emulsion, It is widely used in the form known as lotions, milky lotions, essences, packs, gels, powders, foundations, sun care, pass salts and the like, quasi-drugs and cosmetics.

In the case of producing the external preparation of the present invention, various known and commonly used active ingredients such as carpronium chloride, cepharanthin, vitamin E, vitamin E nicotinate, nicotinic acid, nicotinic acid amide, benzyl nicotinate, and ginger are used. Peripheral vasodilators such as tincture and capsicum tincture, cooling agents such as camphor and menthol, antibacterial agents such as hinokitiol, benzalkonium chloride and undecylenic acid, anti-inflammatory agents such as lysozyme chloride, glycyrrhizin and allantoin, ascorbic acid and arbutin, etc. Various extracts derived from animals, plants, microorganisms such as skin-whitening agent, placenta extract, liver extract, lactic acid bacterium culture extract and the like can be appropriately added and used.

In addition to the known active ingredients and base components such as surfactants and oils and fats, known moisturizers, preservatives and antioxidants may be added to the above-mentioned drugs, quasi drugs and cosmetics. Agent, UV absorber / scattering agent, chelating agent, pH adjusting agent,
Various additives such as fragrances and colorants can be used in combination.

[0037]

EXAMPLES Next, examples and experimental examples of their effects will be shown, but these do not limit the present invention at all.

Experimental Example 1 Mouse melanoma B16 fine
Cell whitening test method A sample is prepared and dissolved in MEM (Eagle's Minimum Essential Medium) so that the final concentration becomes the concentration shown in Table 1.
It was filtered with a sterilization filter having a pore size of 0.45 μm. MEM
The insoluble sample was dissolved in 100 μl of ethanol,
It was added to MEM (In this test, 100 g of the solvent was added to 10 g of the original plant, and the mixture was stirred at room temperature for 3 hours, and then the dried plant extract was evaporated). Dissolve the sample into two plastic petri dishes (Falcon, inner diameter 9 cm), filter and sterilize 8 ml of MEM, FBS
(1 × 10 ⁵ cells / ml of B16 cells suspended in 1 ml of (fetal bovine serum) and 1 ml of MEM was added to start the culture. 3
The medium is replaced after 5 days for a total of 5 days, 5% CO ₂ , 95%
Incubated at 37 ° C. under air condition. After culturing, collect the proliferated cells on the bottom of the dish and use Phosphate buffered saline.
The suspension was suspended in (PBS) and centrifuged at 2,000 rpm for 3 minutes, and the degree of blackening of the obtained cell pellet was visually evaluated.

In Table 1, + -in the macroscopic color tone.
Indicates the following evaluation. -: Shows the same degree of blackening as the non-addition group. +: Shows a slightly lower degree of blackening than the non-addition group. ++: The degree of blackening is clearly smaller than that in the non-addition group. +++: Shows a slightly recognized blackening degree. ++++: White or gray, not black. ++++++: White.

[0040]

[0041]

[0042]

[0043]

[0044]

[0045]

<Experimental Example 2> Inhibition of rat carrageenin edema
Action Male SD rats (body weight 180 to 200 g) subcutaneously injected with 0.1 ml of 1% λ-carrageenin subcutaneously into the footpad of the right hind leg, and immediately after that, a cream preparation prepared separately (effectiveness shown in Table 2 in the cream base below) A formulation containing the components) was applied and the paw volume was measured after 3 hours. The control was a group to which the cream was not applied (control), and only the cream base in which the active ingredient was removed from the cream was also measured. In this test, 10 g of the original plant was added to 100 g of the solvent.
After adding ml, the mixture was stirred at room temperature for 3 hours, and then the dried plant extract was used for evaporation.

[0047]

Cream base for test (% by weight) (A) Monostearic acid Polyoxyethylene glycol (40E.0.) 2.00 Self-emulsifying glyceryl monostearate 5.00 Stearic acid 5.00 Behenyl alcohol 1.00 Liquid paraffin 1.00 Glycerin trioctanoate 10.00 Preservative 0.1 Perfume Small amount (B) 1,3-butylene glycol 5.00 Purified water Residue (A) The components belonging to (A) are dissolved by heating (oil phase), Apart from
A component belonging to the component (B) was dissolved by heating (aqueous phase). The aqueous phase was added to the oil phase, the mixture was stirred and emulsified, and then cooled to obtain a vanishing cream base.

[0049]

[0050]

[0051]

[0052]

[0053]

[0054]

As is clear from the results in Table 2, it was confirmed that the cream of the present invention synergistically exhibited the effects of kojic acid or its derivative and the effects of the plant extract.

[0056]

[Prescription example] The prescription example of the present invention is given below. In the prescription examples, the “appropriate amount” means an amount that makes the entire prescription 100% by weight.

<Formulation Example 1> Cream (% by weight) 1. Polyethylene glycol monostearate (40E.0.) 2.00 2. Self-emulsifying glyceryl monostearate 5.00 3. Stearic acid 5.00 4. Behenyl alcohol 1.00 5. Liquid paraffin 10.00 6. Glyceryl trioctanoate 10.00 7. Paraoxybenzoic acid ester 0.20 8.1,3-butylene glycol 5.00 9. Disodium edetate 0.01 10. Kojic acid 1.00 11. Gardenia (ethanol extract) 0.10 12. Odorikosou (water extract) 0.50 13. Purified water Proper amount Manufacturing method A. Heat 1 to 6 to dissolve. B. 7 to 13 are heated and dissolved. C. Add B to A, emulsify, stir, and cool. D. After C is cooled, it is filled in a container to be a product after inspection. To inunction usage and dose an appropriate amount on the face.

<Formulation Example 2> Emulsion (wt%) 1. Monostearic acid Polyoxyethylene sorbitan (20E.0.) 2.00 2. Tetraoleic acid polyoxyethylene sorbit (60E.0.) 0.50 3. 3. Lipophilic glyceryl monostearate 1.00 4. Stearic acid 0.50 5. Behenyl alcohol 0.50 6. Avocado oil 4.00 7. Glyceryl trioctanoate 4.00 8. Paraoxybenzoic acid ester 0.20 9.1,3-butylene glycol 5.00 10. Xanthan gum 0.14 11. Disodium edetate 0.01 12. Kojic acid 4.00 13. Bear vine (ethanol extract) 5.00 14. Purified water Proper amount Manufacturing method A. Heat 1 to 7 to dissolve. B. Dissolve 8 to 14 by heating. C. Add B to A, emulsify, stir, and cool. D. After C is cooled, it is filled in a container to be a product after inspection. To inunction usage and dose an appropriate amount on the face.

<Formulation Example 3> Lotion (% by weight) 1. Polyoxyethylene hydrogenated castor oil (60E.0.) 8.00 2. Ethanol 15.00 3. Kojic acid glucoside 7.00 4. Black pepper (water extract) 0.01 5. Goatweed (ethanol extract) 0.05 6. Paraoxybenzoic acid ester 0.10 7. Citric acid 0.10 8. Sodium citrate 0.30 9.1,3-butylene glycol 4.00 10. Disodium edetate 0.01 11. Purified water Proper amount Manufacturing method A. Stir 1 to 11 uniformly and dissolve. B. A is filled in a container and the product is obtained after the inspection. To inunction usage and dose an appropriate amount on the face.

(Wt%) <Formulation Example 4> Ointment 1. Polyethylene glycol monostearate (40E.0.) 2.00 2. Self-emulsifying glyceryl monostearate 5.00 3. Stearic acid 5.00 4. Behenyl alcohol 1.00 5. Liquid paraffin 10.00 6. Glyceryl trioctanoate 10.00 7. Paraoxybenzoic acid ester 0.20 8.1,3-butylene glycol 5.00 9. Disodium edetate 0.01 10. Kojic acid 1.00 11. Primrose (ethanol extract) 2.00 12. Spiraea (water extract) 1.00 13. Peony (ethanol extract) 2.00 14. Purified water Proper amount Manufacturing method A. Heat 1 to 6 to dissolve. B. 7 to 14 are heated and dissolved. C. Add B to A, emulsify, stir, and cool. D. After C is cooled, it is filled in a container to be a product after inspection. To inunction usage and dose an appropriate amount on the face.

<Formulation Example 5> Pap agent (% by weight) 1. Polyacrylic acid 30.00 2. Kojic acid 0.50 3. Shobu (75% ethanol extract) 0.10 4. Taiso (water extract) 0.04 5. Spruce (ethanol extract) 0.01 6. Sodium polyacrylate 7.00 7. Aluminum chloride 0.30 8. Concentrated glycerin 20.00 9. Sorbitan monooleate 1.00 10. Titanium oxide 4.00 11. Purified water Proper amount Manufacturing method A. 1 to 5, 9 and 11 are heated and dissolved. B. Heat 6 to 8 and 10 to dissolve. C. Add B to A, stir evenly, and mix. D. After cooling C, it is applied to a coating agent, and a product is obtained after inspection. Usage and dose: Remove the liner and apply to the affected area.

<Formulation Example 6> Bath agent (% by weight) 1. Liquid paraffin 65.00 2. Di-2-heptyl undecanoic acid Glycerin monostearate 5.00 3. 3. Polyoxyethylene (2E.0.) Glycerin monostearate 2.00 4. Polyoxyethylene (9E.0.) Monooleate 2.00 5. Polyoxyethylene (3E.0.) Lauryl ether 5.00 6. Vitamin E 0.20 7. Kojic acid monopalmitate 2.00 8. Dwarf pine (water extract) 5.00 9. Fragrance 1.00 10. Minute amount of dye 11. Ethanol Proper amount production method A. Mix and dissolve 1 to 9. B. Add 10 to 11 and dissolve. C. Add B to A and stir uniformly. D. C was filled in a soft capsule, and a product was obtained after the inspection. Dosage and dosage Put an appropriate amount in the bath and take a bath.

<Formulation Example 7> Essence (% by weight) 1.1% carboxyvinyl polymer solution 10.00 2. Glycerin 20.00 3. Hyaluronic acid 0.50 4. Ethanol 7.00 5. Kojic acid galactoside 3.00 6. Kojic acid 2.00 7. Loquat leaf (water extract) 0.15 8. Mugwort (water extract) 0.05 9. Ladies Mantle (Water Extract) 2.00 10. Rosemary (water extract) 0.01 11. Waremokou (water extract) 0.04 12. Purified water Appropriate amount Production method Each of the above components was mixed, uniformly stirred and dissolved to produce essence. Usage and dose Rub an appropriate amount on the face. It was confirmed that each of the external preparations for skin of Formulation Examples 1 to 7 is a preparation having an effect satisfying the object of the present invention.

[0064]

INDUSTRIAL APPLICABILITY According to the present invention, a specific plant extract is used in combination with kojic acid and / or a derivative thereof to synergistically enhance the whitening effect originally possessed by kojic acid and / or a derivative thereof. An external skin preparation having enhanced anti-inflammatory effect is provided.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification code Internal reference number FI technical display area A61K 35/78 X 8217-4C

Claims (1)

[Claims] 1. Kojic acid and / or a derivative thereof and echinacea, sardine, pine nut, black mustard, goat weed, primrose, spirea, peony, shob, turmeric, spruce, dwarf pine, dokudami, nazuna, parsley, harimokush, biwakushi. Leaf, peach leaf,
An external preparation for skin, which comprises one or more kinds of plant extracts selected from the group consisting of mugwort, ladies' mantle, rosemary, and groundworm.