JPH082315B2 - リンホトキシンを含む融合蛋白質 - Google Patents

リンホトキシンを含む融合蛋白質

Info

Publication number
JPH082315B2
JPH082315B2 JP63-504508A JP50450888A JPH082315B2 JP H082315 B2 JPH082315 B2 JP H082315B2 JP 50450888 A JP50450888 A JP 50450888A JP H082315 B2 JPH082315 B2 JP H082315B2
Authority
JP
Japan
Prior art keywords
plasmid
lymphotoxin
dna
antibody
fusion protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63-504508A
Other languages
English (en)
Japanese (ja)
Other versions
JPH082315B1 (de
JPWO1988009343A1 (ja
Inventor
鉄蔵 三木
誠志 加藤
寛 長田
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Central Glass Co Ltd
Hodogaya Chemical Co Ltd
Nippon Soda Co Ltd
Nissan Chemical Corp
Sagami Chemical Research Institute
Tosoh Corp
Original Assignee
Central Glass Co Ltd
Hodogaya Chemical Co Ltd
Nippon Soda Co Ltd
Nissan Chemical Corp
Sagami Chemical Research Institute
Tosoh Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Central Glass Co Ltd, Hodogaya Chemical Co Ltd, Nippon Soda Co Ltd, Nissan Chemical Corp, Sagami Chemical Research Institute, Tosoh Corp filed Critical Central Glass Co Ltd
Priority to JP63-504508A priority Critical patent/JPH082315B2/ja
Publication of JPWO1988009343A1 publication Critical patent/JPWO1988009343A1/ja
Publication of JPH082315B1 publication Critical patent/JPH082315B1/ja
Publication of JPH082315B2 publication Critical patent/JPH082315B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
    • C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP63-504508A 1987-05-29 1988-05-28 リンホトキシンを含む融合蛋白質 Expired - Lifetime JPH082315B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP63-504508A JPH082315B2 (ja) 1987-05-29 1988-05-28 リンホトキシンを含む融合蛋白質

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP62-131726 1987-05-29
JP13172687 1987-05-29
JP63-504508A JPH082315B2 (ja) 1987-05-29 1988-05-28 リンホトキシンを含む融合蛋白質

Publications (3)

Publication Number Publication Date
JPWO1988009343A1 JPWO1988009343A1 (ja) 1989-07-06
JPH082315B1 JPH082315B1 (de) 1996-01-17
JPH082315B2 true JPH082315B2 (ja) 1996-01-17

Family

ID=15064759

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63-504508A Expired - Lifetime JPH082315B2 (ja) 1987-05-29 1988-05-28 リンホトキシンを含む融合蛋白質

Country Status (6)

Country Link
US (1) US5095096A (de)
EP (1) EP0317641B1 (de)
JP (1) JPH082315B2 (de)
AT (1) ATE87007T1 (de)
DE (1) DE3879395T2 (de)
WO (1) WO1988009343A1 (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004692A (en) * 1987-12-15 1991-04-02 Protein Design Labs, Inc. Cloning and expression of phosopholipase C genes
ZA902949B (en) * 1989-05-05 1992-02-26 Res Dev Foundation A novel antibody delivery system for biological response modifiers
US6267964B1 (en) 1989-08-01 2001-07-31 Affibody Technology Sweden Ab Stabilized protein or peptide conjugates able to bond albumin having extended biological half-lives
SE509359C2 (sv) * 1989-08-01 1999-01-18 Cemu Bioteknik Ab Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel
US5314995A (en) * 1990-01-22 1994-05-24 Oncogen Therapeutic interleukin-2-antibody based fusion proteins
US5238823A (en) * 1990-08-22 1993-08-24 Veterinary Infectious Disease Organization Interleukin-2-leukotoxin gene fusions and uses thereof
US5273889A (en) * 1990-08-22 1993-12-28 University Of Saskatchewan Gamma-iterferon-leukotoxin gene fusions and uses thereof
US5594107A (en) * 1990-08-22 1997-01-14 University Of Saskatchewan Chimeric protein comprising an RTX-family cytotoxin and interferon-2 or interferon
CA2089553C (en) * 1990-08-29 2000-06-27 Paul Schendel Multidomain hematopoiesis stimulators
JPH05255393A (ja) * 1990-09-21 1993-10-05 Ishihara Sangyo Kaisha Ltd ポリペプチド
US5525491A (en) * 1991-02-27 1996-06-11 Creative Biomolecules, Inc. Serine-rich peptide linkers
US7070771B1 (en) 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
EP0965597A4 (de) * 1996-12-27 2003-01-08 Mochida Pharm Co Ltd Zellmembran-wirksame medikamente
ZA200305980B (en) 2001-02-12 2007-01-31 Res Dev Foundation Modified proteins, designer toxins, and methods of making thereof
EP1414471B1 (de) 2001-07-17 2012-06-13 Research Development Foundation Therapeutische Mittel mit pro-apoptotischen Proteinen
US7786282B2 (en) 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US7495090B2 (en) 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
US9493543B2 (en) 2010-02-16 2016-11-15 Novo Nordisk A/S Factor VIII fusion protein

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920196A (en) * 1982-07-30 1990-04-24 Genentech, Inc. Human lymphotoxin
SE462046C (sv) * 1982-08-23 1998-04-27 Pharmacia Biotech Ab Hybrid-DNA-vektor innehållande DNA-sekvens från Staphylococcus aureus, förfarande för dess framställning och bakterie innehållande densamma
SE8300693L (sv) * 1983-02-09 1984-08-10 Sven Lofdahl Sett att framstella och isolera proteiner och polypeptider samt en hybridvektor for detta
US4617266A (en) * 1983-04-28 1986-10-14 Genex Corporation Production of Protein A
ES8708014A1 (es) * 1984-06-07 1987-09-01 Murphy John R Un procedimiento para preparar un gen fusionado que codifica una proteina hibrida susceptible de marcado y empleo en diagnosis.
EP0196864A3 (de) * 1985-03-25 1988-03-23 Cetus Corporation Behandlung und Sekretion von rekombinanten Proteinen mittels alkalischer Phosphatase, dazu verwendbare DNA-Sequenzen und mittels dieser Sequenzen transformierte Zellen
SE8505922D0 (sv) * 1985-12-13 1985-12-13 Kabigen Ab Construction of an igg binding protein to facilitate downstream processing using protein engineering

Also Published As

Publication number Publication date
DE3879395D1 (de) 1993-04-22
WO1988009343A1 (fr) 1988-12-01
US5095096A (en) 1992-03-10
EP0317641A1 (de) 1989-05-31
JPH082315B1 (de) 1996-01-17
EP0317641A4 (en) 1991-07-24
ATE87007T1 (de) 1993-04-15
EP0317641B1 (de) 1993-03-17
DE3879395T2 (de) 1993-06-24

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