JPH08512019A - 免疫反応剤およびキレート化された放射性核種からなるｌ−エナンチオメリックオリゴヌクレオチド複合体を用いる腫瘍ターゲッティング - Google Patents

免疫反応剤およびキレート化された放射性核種からなるｌ−エナンチオメリックオリゴヌクレオチド複合体を用いる腫瘍ターゲッティング

Info

Publication number: JPH08512019A
Authority: JP; Japan
Prior art keywords: residue; enantiomeric; precursor; group; sequence
Prior art date: 1993-03-10
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP6520313A

Other languages

English (en)

Japanese (ja)

Inventor

スノー、ロバート・アレン

ブラック、クリストファー・ダグラス・バリアント

Original Assignee

ザ・ウエルカム・ファウンデーション・リミテッド

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-03-10

Filing date

1994-03-10

Publication date

1996-12-17

1994-03-10 Application filed by ザ・ウエルカム・ファウンデーション・リミテッド filed Critical ザ・ウエルカム・ファウンデーション・リミテッド

1996-12-17 Publication of JPH08512019A publication Critical patent/JPH08512019A/ja

Status Pending legal-status Critical Current

Links

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IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 description 1
150000003212 purines Chemical class 0.000 description 1
125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 description 1
239000010453 quartz Substances 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
MCJGNVYPOGVAJF-UHFFFAOYSA-N quinolin-8-ol Chemical compound C1=CN=C2C(O)=CC=CC2=C1 MCJGNVYPOGVAJF-UHFFFAOYSA-N 0.000 description 1
150000003254 radicals Chemical class 0.000 description 1
238000000163 radioactive labelling Methods 0.000 description 1
239000000941 radioactive substance Substances 0.000 description 1
238000011363 radioimmunotherapy Methods 0.000 description 1
238000001959 radiotherapy Methods 0.000 description 1
230000009257 reactivity Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
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230000010076 replication Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
230000004043 responsiveness Effects 0.000 description 1
230000000717 retained effect Effects 0.000 description 1
238000004007 reversed phase HPLC Methods 0.000 description 1
230000002441 reversible effect Effects 0.000 description 1
WUAPFZMCVAUBPE-UHFFFAOYSA-N rhenium atom Chemical compound [Re] WUAPFZMCVAUBPE-UHFFFAOYSA-N 0.000 description 1
150000003290 ribose derivatives Chemical class 0.000 description 1
108020004418 ribosomal RNA Proteins 0.000 description 1
125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
229910052707 ruthenium Inorganic materials 0.000 description 1
235000019515 salmon Nutrition 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
238000007790 scraping Methods 0.000 description 1
239000008159 sesame oil Substances 0.000 description 1
235000011803 sesame oil Nutrition 0.000 description 1
230000001568 sexual effect Effects 0.000 description 1
150000004760 silicates Chemical class 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
229910052709 silver Inorganic materials 0.000 description 1
239000004332 silver Substances 0.000 description 1
229910001961 silver nitrate Inorganic materials 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000004334 sorbic acid Substances 0.000 description 1
229940075582 sorbic acid Drugs 0.000 description 1
235000010199 sorbic acid Nutrition 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
238000012358 sourcing Methods 0.000 description 1
108010068698 spleen exonuclease Proteins 0.000 description 1
230000002269 spontaneous effect Effects 0.000 description 1
239000007921 spray Substances 0.000 description 1
206010041823 squamous cell carcinoma Diseases 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000007858 starting material Substances 0.000 description 1
210000000130 stem cell Anatomy 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
239000011550 stock solution Substances 0.000 description 1
CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 description 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
150000003464 sulfur compounds Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
239000010414 supernatant solution Substances 0.000 description 1
239000013589 supplement Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
238000001308 synthesis method Methods 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
229910052713 technetium Inorganic materials 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
ILMRJRBKQSSXGY-UHFFFAOYSA-N tert-butyl(dimethyl)silicon Chemical group C[Si](C)C(C)(C)C ILMRJRBKQSSXGY-UHFFFAOYSA-N 0.000 description 1
FGTJJHCZWOVVNH-UHFFFAOYSA-N tert-butyl-[tert-butyl(dimethyl)silyl]oxy-dimethylsilane Chemical compound CC(C)(C)[Si](C)(C)O[Si](C)(C)C(C)(C)C FGTJJHCZWOVVNH-UHFFFAOYSA-N 0.000 description 1
239000012085 test solution Substances 0.000 description 1
YNHJECZULSZAQK-UHFFFAOYSA-N tetraphenylporphyrin Chemical compound C1=CC(C(=C2C=CC(N2)=C(C=2C=CC=CC=2)C=2C=CC(N=2)=C(C=2C=CC=CC=2)C2=CC=C3N2)C=2C=CC=CC=2)=NC1=C3C1=CC=CC=C1 YNHJECZULSZAQK-UHFFFAOYSA-N 0.000 description 1
229910052716 thallium Inorganic materials 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000004797 therapeutic response Effects 0.000 description 1
125000001544 thienyl group Chemical group 0.000 description 1
150000007970 thio esters Chemical class 0.000 description 1
125000004001 thioalkyl group Chemical group 0.000 description 1
150000003556 thioamides Chemical class 0.000 description 1
125000000101 thioether group Chemical group 0.000 description 1
150000003568 thioethers Chemical class 0.000 description 1
ATGUDZODTABURZ-UHFFFAOYSA-N thiolan-2-ylideneazanium;chloride Chemical compound Cl.N=C1CCCS1 ATGUDZODTABURZ-UHFFFAOYSA-N 0.000 description 1
229940113082 thymine Drugs 0.000 description 1
238000012876 topography Methods 0.000 description 1
231100000331 toxic Toxicity 0.000 description 1
230000002588 toxic effect Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
239000003053 toxin Substances 0.000 description 1
231100000765 toxin Toxicity 0.000 description 1
108700012359 toxins Proteins 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
229940048102 triphosphoric acid Drugs 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
229910052721 tungsten Inorganic materials 0.000 description 1
231100000397 ulcer Toxicity 0.000 description 1
238000000108 ultra-filtration Methods 0.000 description 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
229940045145 uridine Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
230000003612 virological effect Effects 0.000 description 1
238000012800 visualization Methods 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1
239000002676 xenobiotic agent Substances 0.000 description 1
230000002034 xenobiotic effect Effects 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Public Health (AREA)
Physics & Mathematics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Optics & Photonics (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Peptides Or Proteins (AREA)

JP6520313A 1993-03-10 1994-03-10 免疫反応剤およびキレート化された放射性核種からなるｌ−エナンチオメリックオリゴヌクレオチド複合体を用いる腫瘍ターゲッティング Pending JPH08512019A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US3308393A	1993-03-10	1993-03-10
US08/033,083		1993-03-10
PCT/US1994/002610 WO1994020523A1 (en)	1993-03-10	1994-03-10	Tumor targeting with l-enantiomeric oligonucleotide conjugates of immunoreagents and of chelated radionuclides

Publications (1)

Publication Number	Publication Date
JPH08512019A true JPH08512019A (ja)	1996-12-17

Family

ID=21868470

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP6520313A Pending JPH08512019A (ja)	1993-03-10	1994-03-10	免疫反応剤およびキレート化された放射性核種からなるｌ−エナンチオメリックオリゴヌクレオチド複合体を用いる腫瘍ターゲッティング

Country Status (5)

Country	Link
EP (1)	EP0691981A1 (de)
JP (1)	JPH08512019A (de)
AU (1)	AU6402594A (de)
CA (1)	CA2157902A1 (de)
WO (1)	WO1994020523A1 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005512978A (ja) *	2001-10-26	2005-05-12	ノクゾンファルマアーゲー	修飾ｌ−核酸

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE203168T1 (de) *	1992-05-07	2001-08-15	Nycomed Imaging As	Komplexbildnermittel und zielimmunoreagenzien
US6444652B1 (en) *	1998-08-10	2002-09-03	Novirio Pharmaceuticals Limited	β-L-2'-deoxy-nucleosides for the treatment of hepatitis B
US6395716B1 (en) *	1998-08-10	2002-05-28	Novirio Pharmaceuticals Limited	β-L-2′-deoxy-nucleosides for the treatment of hepatitis B
US6787526B1 (en)	2000-05-26	2004-09-07	Idenix Pharmaceuticals, Inc.	Methods of treating hepatitis delta virus infection with β-L-2′-deoxy-nucleosides
US6875751B2 (en)	2000-06-15	2005-04-05	Idenix Pharmaceuticals, Inc.	3′-prodrugs of 2′-deoxy-β-L-nucleosides
ATE452655T1 (de) *	2001-06-10	2010-01-15	Noxxon Pharma Ag	Verwendung von l-polynukleotiden zur diagnostischen bilderzeugung
EP1288309A1 (de) *	2001-08-30	2003-03-05	Noxxon Pharma AG	Verfahren zur Markierung von L-Nukleinsäuren
US6942972B2 (en) *	2001-10-24	2005-09-13	Beckman Coulter, Inc.	Efficient synthesis of protein-oligonucleotide conjugates
EP1306382A1 (de) *	2001-10-26	2003-05-02	Noxxon Pharma AG	Modifizierte L-Nukleinsäure
TWI244393B (en)	2002-08-06	2005-12-01	Idenix Pharmaceuticals Inc	Crystalline and amorphous forms of beta-L-2'-deoxythymidine
SI1572095T1 (sl)	2002-09-13	2015-12-31	Novartis Ag	Beta-l-2'-deoksinukleozidi za uporabo pri zdravljenju odpornih sevov hbv

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4863713A (en) *	1986-06-23	1989-09-05	The Board Of Trustees Of Leland Stanford Jr. Univ.	Method and system for administering therapeutic and diagnostic agents
US5158880A (en) *	1988-09-23	1992-10-27	E. I. Du Pont De Nemours And Company	Process for preparing solid perfluorocarbon polymer supports having attached perfluorocarbon-substituted ligand or binder
US5367080A (en) *	1990-11-08	1994-11-22	Sterling Winthrop Inc.	Complexing agents and targeting radioactive immunoreagents useful in therapeutic and diagnostic imaging compositions and methods

1994
- 1994-03-10 EP EP94911542A patent/EP0691981A1/de not_active Withdrawn
- 1994-03-10 WO PCT/US1994/002610 patent/WO1994020523A1/en not_active Ceased
- 1994-03-10 AU AU64025/94A patent/AU6402594A/en not_active Abandoned
- 1994-03-10 CA CA002157902A patent/CA2157902A1/en not_active Abandoned
- 1994-03-10 JP JP6520313A patent/JPH08512019A/ja active Pending

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2005512978A (ja) *	2001-10-26	2005-05-12	ノクゾンファルマアーゲー	修飾ｌ−核酸

Also Published As

Publication number	Publication date
EP0691981A1 (de)	1996-01-17
WO1994020523A1 (en)	1994-09-15
AU6402594A (en)	1994-09-26
CA2157902A1 (en)	1994-09-15

Publication	Publication Date	Title
JP3170235B2 (ja)	2001-05-28	修飾ヌクレオチド
US5633360A (en)	1997-05-27	Oligonucleotide analogs capable of passive cell membrane permeation
JP3186795B2 (ja)	2001-07-11	末端３′−３′または５′−５′ヌクレオチド間結合を有するオリゴヌクレオチド類似体
JP3293820B2 (ja)	2002-06-17	標的ポリヌクレオチドにハイブリツド形成するための新規な一工程方法とポリヌクレオチド化合物
JP4624104B2 (ja)	2011-02-02	オリゴヌクレオチド結合体
JPH08503854A (ja)	1996-04-30	抗体のオリゴヌクレオチド複合体およびキレート化された放射性ヌクレオチドの相補的オリゴヌクレオチド複合体を用いる腫瘍部位の逐次ターゲッティング
DE69129127T2 (de)	1998-10-08	Zielgesuchte radioaktive immunoreagenzien
WO1994020523A1 (en)	1994-09-15	Tumor targeting with l-enantiomeric oligonucleotide conjugates of immunoreagents and of chelated radionuclides
JP3143506B2 (ja)	2001-03-07	治療用物質の標的送達用医薬組成物
JPH07506667A (ja)	1995-07-20	錯化剤並びに治療及び診断用組成物及び方法に有用な標的化免疫試薬
JP4854913B2 (ja)	2012-01-18	オリゴヌクレオチド結合体
US20070010014A1 (en)	2007-01-11	Compositions and methods for enhanced delivery to target sites
JP2009197024A (ja)	2009-09-03	金属複合体及びオリゴヌクレオチドから作られた接合体、該接合体を含む薬剤、放射線診断におけるそれらの使用並びにそれらの製造のための方法
EA010687B1 (ru)	2008-10-30	Гуманизированное антитело
US20020077306A1 (en)	2002-06-20	Conjugates made of metal complexes and oligonucleotides, agents containing the conjugates, their use in radiodiagnosis as well as process for their production
AU5984094A (en)	1994-07-04	Immunoreactive reagents employing dihydrofolate reductase
EP0613379B1 (de)	1998-08-12	Therapeutische Mittel
US20210290787A1 (en)	2021-09-23	Macrocycle conjugates
Giglio et al.	2019	Synthesis and initial evaluation of radioactive 5-I-α-methyl-tryptophan: a Trp based agent targeting IDO-1
JPH09501147A (ja)	1997-02-04	モノアミンオキシダーゼを使用する免疫反応性試薬
JP2002503671A (ja)	2002-02-05	Ｏ６−ベンジルグアニン含有オリゴデオキシリボヌクレオチドおよびその使用
KR20150045592A (ko)	2015-04-29	다양한 압타머에 적용 가능한 방사성동위원소 표지된 핵산 구조체 개발 및 표지방법
CA2154896A1 (en)	1994-08-04	Immunoreactive reagents employing heterodimers
US7713528B1 (en)	2010-05-11	Method for in vivo delivery of active compounds using reagent conjugate
US20070009435A1 (en)	2007-01-11	Compositions and methods for enhanced delivery to target sites

JPH08512019A - 免疫反応剤およびキレート化された放射性核種からなるｌ−エナンチオメリックオリゴヌクレオチド複合体を用いる腫瘍ターゲッティング - Google Patents

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Links

Classifications

Landscapes

Applications Claiming Priority (3)

Publications (1)

Family

ID=21868470

Family Applications (1)

Country Status (5)

Cited By (1)

Families Citing this family (11)

Family Cites Families (3)

Cited By (1)

Also Published As

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