JPH09224687A

JPH09224687A - ポリケチドシンターゼ遺伝子

Info

Publication number: JPH09224687A
Application number: JP9036020A
Authority: JP
Inventors: Bradley Stuart Dehoff; ブラッドリー・スチュアート・ディホフ; Stuart Allen Kuhstoss; スチュアート・アレン・クストス; Paul Robert Rosteck Jr; ポール・ロバート・ロステック・ジュニア; Kimberly Lynn Sutton; キンバリー・リン・サットン
Original assignee: Eli Lilly and Co
Current assignee: Eli Lilly and Co
Priority date: 1996-02-22
Filing date: 1997-02-20
Publication date: 1997-09-02
Also published as: US5876991A; CA2197524A1; EP0791655A3; EP0791655A2

Abstract

(57)【要約】【課題】チラクトンの生合成に関与する多機能性蛋白
をコードするＤＮＡ分子を提供する。【解決手段】 Streptomyces fradiaeから単離されるポ
リケチドシンターゼをコードしているＤＮＡ分子はポリ
ケチドチラクトンの生合成に有用である。

Description

【発明の詳細な説明】

【０００１】本発明は、ポリケチド化合物の生合成をも
たらす多機能性蛋白をコードするＤＮＡ分子、該ＤＮＡ
分子によってコードされる産物、組換えＤＮＡ発現ベク
ター、および形質転換された微生物宿主細胞に関する。
ポリケチドは、構造的および機能的に多様な多数の天然
産物を含む化合物のファミリーである。例えば、ポリケ
チドは、抗生物質、抗腫瘍剤、および免疫抑制剤のよう
な種々の生物活性を有する化合物の構造的バックボーン
を提供する。

【０００２】ポリケチドはこのように極めて多様である
が、共通の生合成機序を共有している。ポリケチドは、
低分子のカルボン酸残基の連続的縮合と、次いで得られ
るβ−ケト炭素（すなわち、β−カルボニル）部分を、
脂肪酸合成と同様な方法で様々に還元する工程とによっ
て合成される。これら多くのポリケチドの種々の反復合
成方法は、必要な種々の活性のための別々の活性部位を
有する高分子の多機能性ポリペプチドコンプレックスに
よって調節される。ポリケチド生合成の一般的反応式
は、例えば、HopwoonおよびShermanの、Annu. Rev. Gen
et., 1990, 24:37、およびKatzおよびDonadioの、 Ann
u. Rev. Microbiol., 1993, 47;875に概説されている。

【０００３】ポリケチドシンターゼ酵素をコードしてい
る天然のＤＮＡ配列は、一般に、一回の合成に必要なす
べての活性をコードし、縮合工程自身と縮合後プロセッ
シング工程を含む反復サブユニット、すなわちモジュー
ルに構成されることが解ってきた。各々の活性は、各縮
合工程に含まれる特定のカルボン酸ビルディングブロッ
クに対する特異性に関与するか、または達成される特定
の縮合後プロセッシング機能を指示する異なる部位に関
連している。例えば、ＰＣＴ公開ＷＯ９３／１３６６３
はSaccharopolyspora erythraeaのポリケチドシンター
ゼをコードする遺伝子の構成について記載している。こ
の遺伝子はいくつかのモジュールで構成されており、各
モジュールが１つの縮合工程を行う。鎖成長の正確な配
列と成長している鎖のプロセッシングは各モジュールに
おける遺伝的情報によって決定される。本ＰＣＴ出願
は、サイクリックラクトンフレームワークの生合成を支
配しているＤＮＡを種々の方法で操作することによって
新規ポリケチド構造物を合成するためのアプローチにつ
いて記載している。しかしながら、この方法論を他のポ
リケチドに適用するには、まず生合成によってプロセッ
シングを生じるＤＮＡ分子を単離する必要がある。

【０００４】本発明はチラクトンシンターゼをコードす
る遺伝子クラスターのＤＮＡ配列、すなわち、チロシン
の基本的ビルディングブロックであるチラクトンのビル
ディング機構に関するものである。その結果、本発明
は、取り込まれるカルボン酸のタイプ、取り込まれるカ
ルボン酸の数、行われた縮合後反応、またはそれらのあ
らゆる組み合わせを変えることによってＤＮＡ配列を修
飾し、新規チロシン関連ポリケチドを得ることを可能に
する。

【０００５】本発明はチラクトンシンターゼドメインを
コードする単離されたＤＮＡ配列を含むＤＮＡ分子を提
供するものである。したがって、本発明は配列番号１の
ＤＮＡ分子とそのサブモジュールを含むＤＮＡ分子を提
供する。本発明は該ＤＮＡ分子によってコードされる産
物、組換えＤＮＡ発現ベクター、および形質転換微生物
宿主細胞をも提供する。

【０００６】図１はStreptomyces fradiae ＤＮＡ
（〜４５ｋｂ）のチラクトンポリケチドシンターゼ領域
（ｔｙｌＧ）のマップである。ｋｂで示される距離はｔ
ｙｌＧの開始部からの距離である。転写解読枠（ＯＲ
Ｆ）は矢印で示す。制限部位は以下のように示す。Ｅ−ＥｃｏＲＩＢ−ＢａｍＨＩ予測される機能性ドメインは以下のように示す。ＡＣＰ−アシルキャリアー蛋白ＡＴ −アシルトランスフェラーゼＤＨ −デヒドラターゼＥＲ −エノイルリダクターゼＫＲ −ケトリダクターゼＫＲ’−不活性と予測されるケトリダクターゼ様ドメイ
ンＫＳ −ケトシンターゼＫＳ’−正常ケトシンターゼ中の活性部位システインが
占める位置にグルタミン残基が存在するケトシンターゼ
様ドメインＴＥ −チオエステラーゼ

【０００７】図２はチラクトン合成の生合成経路であ
る。図３はｔｙｌＧＤＮＡの全領域に及ぶ２つのクロ
ーンのマップである。図４はStreptomyces ambofaciens
ＤＮＡのｓｒｍＧ領域のマップである。ｋｂで示され
る距離はｓｒｍＧの開始部からの距離である。転写解読
枠は矢印で示す。ｓｒｍＧＤＮＡ（０−４２ｋｂ）は
プラテノリドポリケチドシンターゼ領域である。制限部
位は上記および下記のように示す。ＡＰ −ＡｐａＩＧ −ＢｇｌＩＩＫ −ＫｐｎＩＰ −ＰｓｔＩＸ −ＸｈｏＩ予測された機能性ドメインは上記のごとく示す。図５は
プラテノリド合成の生合成経路である。図６はｓｒｍＳ
ＤＮＡの全領域に及ぶ２つのクローンのマップであ
る。

【０００８】ポリケチド類は構造的および機能的多様性
を有する天然産物の大きなクラスである。このクラスの
化合物が有する共通の特徴は、その合成が「ポリケチド
シンターゼ」と呼ばれる多機能性ペプチドコンプレック
スの指示のもとで達成されることである。ポリケチドシ
ンターゼ遺伝子の分子遺伝学的解析によって、異なるポ
リケチド、すなわち、１）本質的に反復的プロセスで作
成される芳香族化合物、および２）少数の非常に大きな
ポリペプチド中に配置された同じ活性を有するいくつか
の反復を含む複合ポリケチド、に作用する２種類の異な
る酵素のクラスが明らかになっている。

【０００９】複合ポリケチドシンターゼ遺伝子のうち、
１つのポリケチドシンターゼは基質特異性をもたらし、
低分子カルボン酸ビルディングブロック（補酵素Ａチオ
エステルの形で）の成長ポリケチド炭素鎖への縮合を触
媒し、そして該縮合反応によって生じるβ−カルボニル
官能基における縮合後プロセッシング反応を触媒する酵
素活性および調節活性を含む。該縮合反応はアシルキャ
リアー蛋白（ＡＣＰ）、β−ケトシンターゼ（ＫＳ）、
およびアシルトランスフェラーゼ（ＡＴ）を含む種々の
活性を必要とする。縮合が生じたら、得られるβ−カル
ボニル官能基を修飾してよい。関与すると思われる縮合
後活性にはβ−ケトリダクターゼ（ＫＲ）、デヒドラタ
ーゼ（ＤＨ）、およびエノイルリダクターゼ（ＥＲ）が
含まれる。ポリケチドの生合成はチオエステラーゼ（Ｔ
Ｅ）活性によって終了する。特定の縮合工程後に、これ
らの活性のすべてもしくはいくつかが作用するか、また
はいずれの活性も作用しないかによって最終産物の構造
が決定される。

【００１０】本発明は、特に、チラクトンの生合成に関
与するポリケチドシンターゼ、すなわちチラクトンシン
ターゼをコードするＤＮＡ配列を提供するものである。
チラクトン自身は、商業上重要な抗生物質であるチロシ
ンのポリケチドバックボーンである。チラクトンシンタ
ーゼ遺伝子クラスターを定義するチラクトンシンターゼ
ＤＮＡ配列は、チラクトンシンターゼの種々の異なる活
性をコードすることによってチラクトンポリケチドの生
合成を導く。

【００１１】チラクトンシンターゼの遺伝子クラスター
は、その機構が解明されている他の複雑なポリケチド生
合成遺伝子のように、「モジュール」と呼ばれる１また
はそれ以上の反復ユニットをそれぞれ含むいくつかの転
写解読枠（ＯＲＦ）が存在することを特徴とする。モジ
ュールは、一回の合成すなわち一縮合工程、およびそれ
に関連するすべてのβ−カルボニルプロセッシング工程
において必要な種々の活性のすべてをコードしている遺
伝的エレメントと定義される。各モジュールは該合成の
縮合部分を達成するＡＣＰ、ＫＳ、およびＡＴ活性、な
らびにβ−カルボニルプロセッシングに作用する選ばれ
た縮合後活性をコードしている。そのようなモジュール
によってコードされるポリペプチドは「シンターゼユニ
ット」と呼ばれる（ＳＵ）。さらに、各モジュールは、
チラクトンシンターゼの種々の活性をコードするサブモ
ジュールを含むことを特徴とする。本発明の目的におい
て、用語「サブモジュール」は種々の活性をコードする
ポリケチドシンターゼＤＮＡ配列の部分、すなわち、
「ドメイン」と定義される。したがって、ドメインは通
常理解されているように、該種々の活性に必要なポリケ
チドシンターゼポリペプチドの部分を意味する。

【００１２】Streptomyces fradiae由来のチラクトン
シンターゼ遺伝子クラスターの構成を図１に示す。図２
には、チラクトン合成経路を、各縮合反応に用いる特異
カルボン酸基質、および種々の縮合後活性とともに示
す。Streptomyces fradiae由来のチラクトンシンター
ゼ遺伝子クラスターを含む好ましいＤＮＡ分子を配列番
号１に示す。本発明の他の好ましいＤＮＡ分子には、個
々の多機能性ポリペプチドをコードする配列番号１の種
々の転写解読枠が含まれる。これは配列番号１の以下の
ヌクレオチド残基で示される。ＯＲＦ１８１６−１４
２３４、ＯＲＦ２１４３５１−１９９４５、ＯＲＦ３
２００１０−３１１９９、ＯＲＦ４３１２３２−３
６０６７、およびＯＲＦ５３６２４９−４１７７４。
これらの配列によってコードされる種々のペプチドの予
測されるアミノ酸配列をそれぞれ配列番号２、３、４、
５、および６に示す。

【００１３】さらに、本発明の他の好ましいＤＮＡ分子
には、１回の合成に必要なすべての活性を含む合成ユニ
ットをコードするモジュールが含まれる。これらは配列
番号１の以下のヌクレオチド残基によって表される。配
列番号１中のスターターモジュール９４２−３９２９、
モジュール１３９９３−８４７１、モジュール２８５
４１−１３９７０、モジュール３１４４１１−１９６
６６、モジュール４２０１３６−２４６１１、モジュー
ル５２４６７５−３０９０２、モジュール６３１３
３７−３５７４３、およびモジュール７３６３６０−
４０８２６。これらのサブモジュールによってコードさ
れる種々のシンターゼユニットの予測されるアミノ酸配
列はそれぞれ以下のアミノ酸残基によって示される。配
列番号２中のスターターＳＵ４３−１０３８、ＳＵ１
１０６０−２５５２、ＳＵ２２５７６−４３８５、
配列番号３中のＳＵ３２１−１７７２、配列番号４中
のＳＵ４４３−１５３４およびＳＵ５１５５６−３
６３１、配列番号５中のＳＵ６３６−１５０４、およ
び配列番号６中のＳＵ７３８−１５２６。

【００１４】さらに他の好ましＤＮＡ分子には、チラク
トンシンターゼの種々のドメインをコードする種々のサ
ブモジュールが含まれる。これらのサブモジュールは以
下のヌクレオチド残基によって示される。配列番号１中
のモジュール１のＫＳ^Q（ｓ）９４２−２１５６、ＡＴ
（ｓ）２５７１−３５５７、ＡＣＰ（ｓ）３６７５−３
９２９、ＫＳ１３９９３−５２６４、ＡＴ１５６３
１−６６１７、ＫＲ１７４１０−７９４９、およびＡＣ
Ｐ１８２２０−８４７１、配列番号１中のモジュール
２のＫＳ２８５４１−９８１２、ＡＴ２１０２６０
−１１２４６、ＤＨ２１１３１９−１１８７６、ＫＲ
２１２８６１−１３４１５、およびＡＣＰ２１３７
１９−１３９７０、配列番号１中のモジュール３のＫＳ
３１４４１１−１５６９７、ＡＴ３１６０５５−１
７１２２、ＤＨ３１７１９８−１７７９４、ＫＲ３
１８５８４−１９１３８、およびＡＣＰ３１９４１５
−１９６６６、配列番号１中のモジュール４のＫＳ４
２０１３６−２１４０４、ＡＴ４２１７７１−２２７
５７、ＫＲ’４２３５４１−２４０７７、およびＡＣ
Ｐ４２４３６０−２４６１１、配列番号１中のモジュ
ール５のＫＳ５２４６７５−２５９４９、ＡＴ５２６
２９２−２７２８４、ＤＨ５２７３６０−２７９１
７、ＥＲ５２８７６７−２９８１３、ＫＲ５２９８
２９−３０３６８、およびＡＣＰ５３０６５１−３０
９０２、配列番号１中のモジュール６のＫＳ６３１３
３７−３２６０８、ＡＴ６３２９７５−３３９６１、
ＫＲ６３４６９４−３５２３６、およびＡＣＰ６３
５４９２−３５７４３、および配列番号１中のモジュー
ル７のＫＳ７３６３６０−３７６３１、ＡＴ７３７
９８９−３８９８７、ＫＲ７３９７５９−４０３１
３、ＡＣＰ７４０５７５−４０８２６、およびＴＥ７
４１２３５−４１３３３。

【００１５】これらのサブモジュールによってコードさ
れる種々のドメインの予測されるアミノ酸配列は、それ
ぞれ配列番号２中のＫＳ^Q（ｓ）４３−４４７、ＡＴ
（ｓ）５８６−９１４、ＡＣＰ（ｓ）９５４−１０３
８、ＫＳ１１０６０−１４８３、ＡＴ１１６０６−
１９３４、ＫＲ１２１９９−２３７８、およびＡＣＰ
１２４６９−２５５２；配列番号２中のＫＳ２２５７
６−２９９９、ＡＴ２３１４９−３４７７、ＤＨ２３
５０２−３６８７、ＫＲ２４０１６−４２００、およ
びＡＣＰ２４３０２−４３８５；配列番号３中のＫＳ
３２１−４４９、ＡＴ３５６９−９２４、ＤＨ３
９５０−１１４８、ＫＲ３１４１２−１５９６、およ
びＡＣＰ３１６８９−１７７２；配列番号４中のＫＳ
４４３−４６５、ＡＴ４５８８−９１６、ＫＲ’４
１１７８−１３５６、およびＡＣＰ４１４５１−１
５３４、配列番号４中のＫＳ５１５５６−１９８０、
ＡＴ５２０９５−２４２５、ＤＨ５２４５１−２６
３６、ＫＲ５３２７４−３４５３、およびＡＣＰ５
３５４８−３６３１；配列番号５中のＫＳ６３６−４
５９、ＡＴ６５８２−９１０、ＫＲ６１１５５−１
３３５、およびＡＣＰ６１４２１−１５０４；および
配列番号６中のＫＳ７３８−４６１、ＡＴ７５８１
−９１３、ＫＲ７１１７１−１３５５、ＡＣＰ７１
４４３−１５２６、およびＴＥ１６６３−１６９５。

【００１６】いかなる特定の技術的説明にも拘束される
ことを望むものではないが、種々のポリケチドシンター
ゼ遺伝子は、ドメインの境界間に配列の類似性が存在す
る。したがって、当業者は既知のポリケチドシンターゼ
遺伝子の配列情報に基づいて新たに発見されたポリケチ
ドシンターゼ遺伝子のドメイン境界を予測することがで
きる。特に、本出願のサブモジュール、ドメイン、およ
び転写解読枠の境界は、本出願に開示された配列情報お
よびエリスロマイシンポリケチドシンターゼのドメイン
境界の位置に基づいて予測される（Donadioらの、Gene
111:51(1992))。

【００１７】チラクトンシンターゼ遺伝子のＤＮＡ配列
はStreptomyces fradiaeのＤＮＡから作製した組換え
ＤＮＡクローンから決定された。チラクトンシンターゼ
遺伝子は、E. coli K12 MM294中の組換えＤＮＡベクタ
ーｐＳＥＴ５０６およびｐＳＥＴ５０７（図３）に含ま
れており、National Center for Atricultural Utiliza
tion Research, 1815 North University Street, Peori
a, Illinois 61604-3999から入手可能である（各々、寄
託番号NRRL B-18688（寄託日、1990年７月１９日）およ
びNRRL B-18689（寄託日、1990年７月19日））。

【００１８】細菌ＤＮＡの単離技術は当該技術分野でよ
く知られており、容易に利用可能である。そのような技
術のあらゆるものを本発明に用いることができる。特
に、これらの培養物由来のＤＮＡは以下のごとく単離さ
れる。E. coli K12 MM294/pSET506またはE. coli K12
MM294/pSET507の凍結乾燥物を、１００μｇ／ｍＬアン
ピシリンを含むＬ−寒天（１Ｌ当たりトリプトン１０
ｇ、ＮａＣｌ１０ｇ、酵母エキス５ｇ、および寒天１
５ｇ）プレート上に接種し、該株の単一コロニー分離物
を得る。このコロニーを用いて１００μｇ／ｍＬアンピ
シリンを含むＬ−ブロス（１Ｌ当たりトリプトン１０
ｇ、ＮａＣｌ１０ｇ、酵母エキス５ｇ）約５００ｍＬ
に接種し、得られる培養物を曝気しながら３７℃で、細
胞が定常期に達するまで培養する。コスミッドＤＮＡは
該細胞から当該技術分野で知られた方法に従って得られ
る（例えば、Raoらの、Method in Enzymology, 153:16
6, 1987参照）。

【００１９】本発明のＤＮＡは、ラジオアイソトープ標
識または蛍光標識を用いるジデオキシヌクレオチド鎖−
終止法（Sangerらの、Proc. Natl. Acad. Sci. 74: 546
3(1977))のような当該技術分野で知られたあらゆる技術
を用いて配列決定することができる。２本鎖超螺旋ＤＮ
Ａを、配列特異的オリゴヌクレオチドプライマーを用い
る連鎖反応の鋳型として直接用いた。あるいはまた、フ
ラグメントを用いて、バクテリオファージＭ１３中のラ
ンダムなオーバーラッピング配列またはプラスミドベク
ター中のネスト化したオーバーラッピング欠失のいずれ
かのライブラリーを製造した。次いで、個々の組換えＤ
ＮＡサブクローンを、ベクター特異的オリゴヌクレオチ
ドプライマーを用いてシークエンスした。放射活性反応
産物を、変性ポリアクリルアミドゲル上で電気泳動し、
オートラジオグラフィーによって分析した。蛍光標識反
応産物を電気泳動し、Applied Biosystems (ABI Divisi
on, Perkin Elmer, Foster City, CA 94404)モデル３７
０Ａおよび３７３ＡまたはDuPont (Wilmington, DE) Ge
nesis DNAシーケンサーを用いて分析した。配列データ
の整理と編集は、Genetic Center Group (GCG, Madiso
n, WI)プログラムのGelAssembleおよびSeqedまたはABI
モデル６７０Inherit Sequence Analysisシステム、お
よびAutoAssemblerおよびSeqEdプログラムを用いて行っ
た。

【００２０】ドメイン、シンターゼユニット、または多
機能性ポリペプチドに対応するポリペプチドは、例え
ば、既知の発現ベクターを用いて細菌中でｃＤＮＡ配列
を発現させることによって製造することができる。ある
いはまた、上記ポリペプチドは、Straptomyces fradiae
のようなチラクトン産生細菌から抽出することができ
る。さらに、合成化学の技術を用いて上記ポリペプチド
を合成することができる。同種蛋白またはポリペプチド
を単離・精製する方法と技術は当該技術分野でよく知ら
れている。チラクトンシンターゼ遺伝子クラスターの遺
伝的構成は、チラクトンの合成を終了するのに必要な反
応のオーダー、チラクトンシンターゼＤＮＡ配列の知
識、その遺伝的構成、および他の方法では利用できな
い、予測される構造を有する新規ポリケチドの産生を可
能にする遺伝子の特定の転写解読枠、モジュール、およ
びサブモジュールと関連する活性に対応している様であ
る。縮合工程のどこかで用いられる最初のカルボン酸ビ
ルディングブロック、または加えられる該ビルディング
ブロックのいずれかを変化させるＤＮＡ配列に対して修
飾を行ってよい。チラクトンシンターゼ遺伝子を修飾
し、実際に行われる縮合工程数を変えることにより、炭
素バックボーンのサイズを変えてもよい。縮合後プロセ
ッシング活性をコードするＤＮＡ配列の部分に対する修
飾は、炭素鎖バックボーンの種々の縮合部位にみられる
官能基を変化させるであろう。

【００２１】この修飾は、チラクトンシンターゼ遺伝子
由来の、異なる活性を有する別のポリケチドシンターゼ
遺伝子からの対応サブモジュールの既知の活性を有する
サブモジュールを置換することによって達成することが
できる。チラクトンシンターゼ由来のサブモジュールを
他のポリケチドシンターゼ遺伝子由来のサブモジュール
と組み合わせることによって、さらに触媒工程を行って
もよい。したがって、他のポリケチドシンターゼ遺伝子
のＤＮＡ配列由来のサブモジュールが、チラクトンシン
ターゼ由来の少なくとも１つのサブモジュールで置換さ
れているか、またはそれらが組み合わさっているＤＮＡ
分子も本発明によって提供される。さらに、本発明の一
部であるサブモジュールを選択的に不活化することによ
り、予測可能な新規ポリケチド構造を生じさせてもよ
い。例えば、ＫＳ’活性、ＡＴ活性、およびＡＣＰ活性
をコードする、チラクトンシンターゼ遺伝子の第一転写
解読枠（ＯＲＦ１）由来のすべてのサブモジュールは、
プラテノリドシンターゼ遺伝子中の対応サブモジュール
に変換された（実施例２参照）。プラテノイドは、抗生
物質のスピラマイシンのポリケチドバックボーンであ
る。

【００２２】チラクトンシンターゼ遺伝子由来のサブモ
ジュールは、プロピオネートを最初のビルディングブロ
ックとして取り込むのを触媒するドメインをコードして
いるが、プラテノイドシンターゼ遺伝子の対応サブモジ
ュールはアセテートビルディングブロックの取り込みを
触媒するドメインをコードしている。得られるＤＮＡ分
子を細菌株中に入れ、ポリケチド合成を促進する条件下
で増殖させると、成長するポリケチド鎖の出発点にさら
にメチル側鎖が取り込まれることにより予測される構造
を有するハイブリッド分子、特に１６−メチルプラテノ
イドが合成された。

【００２３】遺伝コードの縮重は当業者によく知られて
いる。したがって、当業者はこの開示によって提供され
る特定のＤＮＡ配列を修飾することによって、本明細書
において具体的に提供されるポリペプチドに比べ、同じ
かまたは改良された特性を有する蛋白を提供することが
できる。当業者は、該ＤＮＡ配列を修飾することによっ
て、より高レベルで発現する、本発明で提供する蛋白と
同一の蛋白を発現させることもできる。さらに、本発明
に含まれる組換えＤＮＡベクターまたはコード配列を製
造するのに有用と思われるＤＮＡ配列の部分または全体
を合成的に製造する方法は当業者によく知られている。
さらに、提供されたＤＮＡ配列を修飾するための組換え
方法には、例えば、部位指向性欠失または部位指向性突
然変異誘発が含まれてよい。これらの技術は当業者によ
く知られており、本明細書中でさらに詳細に説明する必
要はない。したがって、本明細書で用いている、天然の
供給源から単離されるか、合成的または半合成的に製造
されるか、または組換えＤＮＡ法によって修飾されるＤ
ＮＡは本発明の範囲に含まれる。

【００２４】同様に、当業者は、本発明のポリペプチド
を組換え的に発現させてよいことを認識するであろう。
あるいはまた、このポリペプチドの全体または一部を、
一般に知られた組換え以外の技術、例えば、固相合成法
によって合成してもよい。したがって、本発明は、例示
したいかなる特定のベクター構築物や特定のポリケチド
シンターゼ分子の製造法にも必ずしも限定されるもので
はないと解釈すべきである。本発明のポリペプチドを製
造するためのこの代替法は本発明に含まれるべきであ
る。

【００２５】多くの環化ポリケチドは１またはそれ以上
の部位でグリコシル化を受ける。チロシンは３個の糖残
基が付着した１６員のサイクリックラクトン、すなわち
チラクトンである。チラクトンをチロシンに変換する方
法は、当該技術分野でよく知られている。本発明は、チ
ラクトンを基にして新規チロシン関連ポリケチドを合成
するのに必要な情報をも提供する。その原理はすでに既
述している。さらに、本明細書に記載のＤＮＡ配列情報
に基づいてin vivoまたはin vitroの転写後または翻訳
後修飾によって得られる産物は本発明に含まれるべきで
ある。以下の実施列は単に例示のためのものであって、
先に明確に記載されている本発明の範囲を限定すること
を意図するものではない。

【００２６】

【実施例】実施例１ Streptomyces fradiaeのＤＮＡ配列チラクトンシンターゼ遺伝子、ｔｙｌＧのＤＮＡ配列
は、累加的に見ればｔｙｌＧの全領域をカバーしてい
る、連続的な、あるいはオーバーラップしているＤＮＡ
断片を含む組換えＤＮＡサブクローンの挿入物を配列決
定することによって得られた。ｔｙｌＧを表わすすべて
の配列はオーバーラッピングコスミッドサブクローンの
ｐＳＥＴ５０６およびｐＳＥＴ５０７中に完全に含まれ
る。本発明によれば、図３に示したマップ上の３．０お
よび４．０ｋｂのＥｃｏＲＩ制限部位によって示された
ＤＮＡフラグメント、４．０ｋｂのＥｃｏＲＩ部位およ
び７．５ｋｂのＢａｍＨＩを境界とするフラグメント、
７．５、１２．０、２３．４、２７．３、３４．６、３
９．５、および５０．５ｋｂのＢａｍＨＩ部位を境界と
するフラグメントをサブクローンし、配列決定すること
によって、該フラグメントが得られよう。

【００２７】単一ＤＮＡフラグメント上のｔｙｌＧ遺伝
子を得るために、制限酵素ＥｃｏＲＩおよびＢａｍＨＩ
を用いるｐＳＥＴ５０６の部分消化物から、３．０ｋｂ
のＥｃｏＲＩ部位および３４．６ｋｂのＢａｍＨＩ部位
を境界とする３１．６ｋｂＤＮＡフラグメントを単離す
る。３４．６および５０．５ｋｂのＢａｍＨＩ部位を境
界とする１５．９ｋｂＤＮＡフラグメントを、制限酵
素ＢａｍＨＩを用いるｐＳＥＴ５０７の部分消化物から
単離する。得られるフラグメントを連結し、適切なＤＮ
Ａベクター中にクローンする。正しい方向に連結された
２つのフラグメントを含むクローンは、制限酵素部位マ
ッピングによって同定される。

【００２８】実施例２プラテノイドおよびチラクトンのポリケチドハイブリッ
ドの産生ポリケチドであるプラテノイドおよびチラクトンのラク
トン環は同じ縮合後プロセッシング工程を受ける。しか
しながら、これら２つのポリケチドは１種類以上のカル
ボン酸の縮合によって合成され、この２つの経路に取り
込むために選ばれる特定のビルディングブロックは異な
る。プラテノイド遺伝子クラスターの構成を図４に示
し、それに伴う合成経路を図５に示す。プラテノイド合
成の各縮合反応および縮合後活性に使用される特異的カ
ルボン酸基質が示されている。

【００２９】Streptomyces ambofaciensプラテノイドシ
ンターゼ（ｓｒｍＧ）遺伝子のＤＮＡ配列は、合わせて
見れば全ｓｒｍＧ領域をカバーする、連続したあるいは
オーバーラップしているＤＮＡ断片を含む組換えＤＮＡ
サブクローンの挿入物を配列決定することによって得ら
れた。ｓｒｍＧを意味するすべての配列は、オーバーラ
ッピングコスミッドクローンのｐＫＣ１０８０およびｐ
ＫＣ１３０６中に完全に含まれる（図６）。該配列は、
１位、０．３ｋｂ、８．２ｋｂ、１４．１ｋｂ、２０．
２ｋｂ、２９．５ｋｂ、３１．４ｋｂ、４１．１ｋｂ、
および４２．０ｋｂのＮｒｕＩ部位を境界とするフラグ
メントをサブクローンし、配列決定することによって得
ることができる。

【００３０】単一フラグメント上のｓｒｍＧ領域を得る
ために、制限酵素ＮｒｕＩおよびＳｆｕＩを用いるｐＫ
Ｃ１０８０の部分消化物から、１位のＮｒｕＩ部位およ
び２５．０ｋｂのＳｆｕＩ部位を境界とする２５．０ｋ
ｂのフラグメントを単離する。２５．０ｋｂおよび４
２．８ｋｂのＳｆｕＩ部位を境界とする１７．８ｋｂＤ
ＮＡフラグメントを、制限酵素ＳｆｕＩを用いるｐＫＣ
１３０６の消化によって単離する。得られるフラグメン
トを連結し、適切なＤＮＡベクター中にクローンする。
正しい方向に連結された２つのフラグメントを含むクロ
ーンは、制限酵素部位マッピングによって同定される。
チラクトンポリケチドシンターゼＤＮＡを、対応するプ
ラテノイドＤＮＡで置換することにより、以下の新規ポ
リケチド構造がもたらされた。

【００３１】プラテノイドを産生するStreptomyces amb
ofaciensのある株はＯＲＦ１のほとんどを欠失して構築
された。このＯＲＦ１欠損株は検出可能なプラテノイド
を産生しなかった。ＯＲＦ１の欠損がプラテノイド産
生における唯一の欠陥であることを確認するため、ＯＲ
Ｆ１を含むがＯＲＦ２〜５のいかなる機能的活性も含ま
ない構築物が、ストレプトマイセス科の放線菌のファー
ジであるΦＣ３１由来の部位特異的統合機能を含むベク
ターによってＯＲＦ１欠損株中に導入された。ΦＣ３１
ａｔｔ部位におけるＯＲＦ１の統合によってスピラマ
イシン産生は親のレベルまで回復し、ＯＲＦ１が機能性
蛋白をコードし、ＯＲＦ２〜５がＯＲＦ１欠損株中で発
現していることが確認された。

【００３２】ｔｙｌＧのＯＲＦ１はｓｒｍＧＯＲＦ１
同様に構成される。ｔｙｌＯＲＦ１由来のＫＳ’、Ａ
Ｔ、およびＡＣＰをコードするＤＮＡは、ｓｒｍＯＲ
Ｆ１のＥｃｏＲＩ−ＡｐａＩフラグメントをｔｙｌＯ
ＲＦ１由来のＥｃｏＲＩ−ＳｆｕＩフラグメントで置き
換えることによってｓｒｍＯＲＦ１由来の対応領域と
置換され、プラスミドｐＫＣ１５２４が作製された。ｐ
ＫＣ１５２４がＯＲＦ１欠損株中に導入されると、ポリ
ケチド合成は回復した。薄層クロマトグラフィーおよび
ＨＰＬＣによる分析では、ポリケチド合成が回復した株
によって産生された産物はStreptomyces ambofaciensの
親株の産生する産物と区別できなかった。

【００３３】ハイブリッドＯＲＦ１ＤＮＡ配列は配列
番号７に示され、ＯＲＦ１コードポリペプチドのアミノ
酸配列は配列番号８に示される。該ハイブリッド分子の
ＤＮＡ配列の残りの部分は、最初のｔｙｌＧ配列と同じ
であり、したがって、この残りの部分によってコードさ
れるポリペプチドも同じである。推定上の新規ポリケチ
ドの物理学的分析を簡単にするために、ポリケチド合成
回復株から、糖合成または付加をコードするＸｈｏＩフ
ラグメントを欠失させた。このフラグメントの欠失によ
って、いかなる糖残基も付加されていないラクトンのみ
を産生する株がもたらされた。ＮＭＲおよび質量分光分
析法によって分析すると、この糖欠損株によって産生さ
れた単離産物は、プラテノリド合成において通常利用さ
れるアセテートの代わりにプロピオネートを取り込むこ
とから予測される構造である、１６−メチル−プラテノ
リドであることが確認された。

【００３４】

【配列表】

【００３５】配列番号：１配列の長さ：４３２８０塩基対配列の型：核酸鎖の数：一本鎖トポロジー：直鎖状配列の種類：ＤＮＡ（ｇｅｎｏｍｉｃ）配列の特徴特徴を表す記号：ＣＤＳ存在位置：８１６．．１４２３４配列の特徴特徴を表す記号：ＣＤＳ存在位置：１４３５１．．１９９４５配列の特徴特徴を表す記号：ＣＤＳ存在位置：２００１０．．３１１９９配列の特徴特徴を表す記号：ＣＤＳ存在位置：３１２３２．．３６０６７配列の特徴特徴を表す記号：ＣＤＳ存在位置：３６２４９．．４１７７４配列 GAATTCGCGG TCCGCTCGGG TTCCGGTCCG TTTTCTGCTT CGAGCGTCTG TGTCGTCATC 60 TCGGCTCTCT CATCGGGCTG GTGCGGGAAG GCATCCCGGT GCGGGGAGAC ATCCTGCTGC 120 GGGAAGGAAT CCTGGTGCGG GAAGGCAACG ACTGCGGGAC GCGGGAGAAA GGGGAATCGG 180 CGGGAATTTC CCCCGCGCGG CGGGGACGGT GCCGGAGAAC AACGGCGGGG AAACAGCCCG 240 CGGTCCGTGA CGACAACGGA AACTATGGTC CGCTTCCTCC GTCCACAAGG CGGAACCTGA 300 CATAGTCCCC GCCCACGCGG AAATCCCGCA CGGCGGCCCG CCGGCCGCCG CACCGGACCT 360 GACATAGCCT CGCCGGACCG CTCCGGTGCG GCCACCCCGT TGGTGTTGGG TGATGAGGTA 420 CCGGATCAGA GGAGAAAGCA CCATGCCCCG CCCCTCGGCC AGCGAACCGC GCGGGACCAC 480 CCGTTCGGCG ACCGCGCTGG CGCGCCGCCG TGGACCGGGC CGTAACTCCC CTGCGCCATC 540 GAATACTTCG CCCCTCGAAT CCCTCACCGG GCGAGTTCCA GGACCGCCCC TCGCTCTCGC 600 CATACCGGAG AACGAACCCG AACGGCACGG CGGAAAGCCC GTCCGCAATG CCCGGGACAT 660 TCCTGTGACC CGACAACACG GTTTGCCGAC ACGGTTCGCC GCAACGCTTG TTGGCAGGCT 720 CACCGGCACG GCCCGCTGAC ACAGCTCGGT GACACGGCAG CCTGACGGGA AACCGCCGAA 780 GCCTCTGGAG TCCTCGCACA TTCCGGAGAG AACAG GTG TCT TCC GCG CTG CGG 833 Met Ser Ser Ala Leu Arg 1 5 CGC GCG GTG CAA TCC AAC TGT GGC TAC GGA GAC CTC ATG ACC TCG AAC 881 Arg Ala Val Gln Ser Asn Cys Gly Tyr Gly Asp Leu Met Thr Ser Asn 10 15 20 ACC GCT GCA CAG AAC ACC GGC GAC CAG GAA GAC GTC GAC GGT CCC GAC 929 Thr Ala Ala Gln Asn Thr Gly Asp Gln Glu Asp Val Asp Gly Pro Asp 25 30 35 AGC ACA CAC GGT GGG GAG ATC GCC GTC GTG GGA ATG TCG TGC CGT CTG 977 Ser Thr His Gly Gly Glu Ile Ala Val Val Gly Met Ser Cys Arg Leu 40 45 50 CCG GGC GCG GCC GGT GTC GAG GAA TTC TGG GAA CTG CTG CGC AGC GGA 1025 Pro Gly Ala Ala Gly Val Glu Glu Phe Trp Glu Leu Leu Arg Ser Gly 55 60 65 70 CGC GGT ATG CCC ACC CGT CAG GAC GAC GGC ACC TGG CGG GCC GCC CTG 1073 Arg Gly Met Pro Thr Arg Gln Asp Asp Gly Thr Trp Arg Ala Ala Leu 75 80 85 GAG GAC CAC GCC GGC TTC GAC GCC GGG TTC TTC GGC ATG AAC GCC CGG 1121 Glu Asp His Ala Gly Phe Asp Ala Gly Phe Phe Gly Met Asn Ala Arg 90 95 100 CAG GCC GCC GCC ACC GAC CCG CAG CAC CGA CTG ATG CTG GAA CTC GGA 1169 Gln Ala Ala Ala Thr Asp Pro Gln His Arg Leu Met Leu Glu Leu Gly 105 110 115 TGG GAG GCA CTG GAG GAC GCG GGC ATC GTC CCC GGC GAT CTC ACC GGC 1217 Trp Glu Ala Leu Glu Asp Ala Gly Ile Val Pro Gly Asp Leu Thr Gly 120 125 130 ACC GAC ACC GGA GTC TTC GCC GGC GTG GCG TCC GAC GAC TAT GCC GTT 1265 Thr Asp Thr Gly Val Phe Ala Gly Val Ala Ser Asp Asp Tyr Ala Val 135 140 145 150 CTC ACC CGC CGT TCC GCC GTC TCC GCC GGG GGA TAC ACC GCC ACG GGG 1313 Leu Thr Arg Arg Ser Ala Val Ser Ala Gly Gly Tyr Thr Ala Thr Gly 155 160 165 CTG CAC CGC GCC CTG GCC GCC AAC CGC CTC TCC CAC TTC CTG GGC CTG 1361 Leu His Arg Ala Leu Ala Ala Asn Arg Leu Ser His Phe Leu Gly Leu 170 175 180 CGC GGC CCC AGC CTG GTC GTC GAC TCG GCC CAG TCC GCC TCA CTG GTG 1409 Arg Gly Pro Ser Leu Val Val Asp Ser Ala Gln Ser Ala Ser Leu Val 185 190 195 GCC GTC CAG CTC GCC TGC GAG AGT CTG CGC CGG GGT GAG ACG TCG CTC 1457 Ala Val Gln Leu Ala Cys Glu Ser Leu Arg Arg Gly Glu Thr Ser Leu 200 205 210 GCC GTC GCG GGC GGT GTC AAC CTC ATC CTC ACC GAG GAG AGC ACC ACC 1505 Ala Val Ala Gly Gly Val Asn Leu Ile Leu Thr Glu Glu Ser Thr Thr 215 220 225 230 GTC ATG GAG CGT ATG GGA GCG CTC TCA CCC GAC GGC CGC TGC CAC ACC 1553 Val Met Glu Arg Met Gly Ala Leu Ser Pro Asp Gly Arg Cys His Thr 235 240 245 TTC GAC GCC CGC GCC AAC GGC TAC GTA CGC GGC GAG GGC GGC GGA GCC 1601 Phe Asp Ala Arg Ala Asn Gly Tyr Val Arg Gly Glu Gly Gly Gly Ala 250 255 260 GTC GTG CTC AAG CCA CTG GAC GCC GCA CTC GCC GAC GGC GAC CGC GTG 1649 Val Val Leu Lys Pro Leu Asp Ala Ala Leu Ala Asp Gly Asp Arg Val 265 270 275 TAC TGC GTC ATC AAG GGA GGT GCC GTC AAC AAC GAC GGC GGC GGC GCG 1697 Tyr Cys Val Ile Lys Gly Gly Ala Val Asn Asn Asp Gly Gly Gly Ala 280 285 290 AGC CTC ACC ACT CCC GAC CGG GAG GCG CAG GAA GCT GTG CTG CGC CAG 1745 Ser Leu Thr Thr Pro Asp Arg Glu Ala Gln Glu Ala Val Leu Arg Gln 295 300 305 310 GCC TAC CGG CGG GCG GGC GTC AGC ACC GGC GCC GTC CGC TAC GTC GAG 1793 Ala Tyr Arg Arg Ala Gly Val Ser Thr Gly Ala Val Arg Tyr Val Glu 315 320 325 CTG CAC GGG ACC GGC ACC CGG GCC GGC GAC CCC GTC GAG GCG GCC GCA 1841 Leu His Gly Thr Gly Thr Arg Ala Gly Asp Pro Val Glu Ala Ala Ala 330 335 340 CTG GGC GCC GTG CTC GGG GCG GGG GCG GAC AGC GGC CGC AGC ACG CCG 1889 Leu Gly Ala Val Leu Gly Ala Gly Ala Asp Ser Gly Arg Ser Thr Pro 345 350 355 CTC GCC GTC GGC TCG GTG AAG ACC AAC GTC GGC CAT CTG GAG GGC GCG 1937 Leu Ala Val Gly Ser Val Lys Thr Asn Val Gly His Leu Glu Gly Ala 360 365 370 GCG GGC ATC GTC GGA CTG ATC AAG GCC ACG CTG TGC GTA CGG AAG GGC 1985 Ala Gly Ile Val Gly Leu Ile Lys Ala Thr Leu Cys Val Arg Lys Gly 375 380 385 390 GAA CTC GTC CCC AGC CTC AAC TTC AGC ACG CCG AAC CCT GAC ATC CCC 2033 Glu Leu Val Pro Ser Leu Asn Phe Ser Thr Pro Asn Pro Asp Ile Pro 395 400 405 CTC GAC GAC CTG CGG CTG CGC GTC CAG ACC GAA CGG CAG GAG TGG AAC 2081 Leu Asp Asp Leu Arg Leu Arg Val Gln Thr Glu Arg Gln Glu Trp Asn 410 415 420 GAG GAG GAC GAC CGG CCG CGC GTG GCC GGC GTC TCC TCC TTC GGT ATG 2129 Glu Glu Asp Asp Arg Pro Arg Val Ala Gly Val Ser Ser Phe Gly Met 425 430 435 GGC GGA ACC AAT GTC CAC CTC GTG ATC GCG GAG GCT CCG GCC GCG GCG 2177 Gly Gly Thr Asn Val His Leu Val Ile Ala Glu Ala Pro Ala Ala Ala 440 445 450 GGG TCC TCC GGG GCG GGG GGT TCG GGC GCT GGT TCC GGT GCC GGT ATC 2225 Gly Ser Ser Gly Ala Gly Gly Ser Gly Ala Gly Ser Gly Ala Gly Ile 455 460 465 470 AGC GCT GTT TCT GGT GTG GTG CCG GTG GTG GTT TCG GGG CGT TCG CGG 2273 Ser Ala Val Ser Gly Val Val Pro Val Val Val Ser Gly Arg Ser Arg 475 480 485 GTG GTG GTG CGG GAG GCT GCG GGC CGG TTG GCG GAG GTG GTG GAG GCC 2321 Val Val Val Arg Glu Ala Ala Gly Arg Leu Ala Glu Val Val Glu Ala 490 495 500 GGT GGT GTG GGG CTG GCG GAT GTG GCG GTG ACG ATG GCG GAC CGG TCG 2369 Gly Gly Val Gly Leu Ala Asp Val Ala Val Thr Met Ala Asp Arg Ser 505 510 515 CGG TTT GGG TAT CGG GCG GTT GTG CTG GCT CGG GGT GAG GCT GAG CTT 2417 Arg Phe Gly Tyr Arg Ala Val Val Leu Ala Arg Gly Glu Ala Glu Leu 520 525 530 GCC GGG CGT TTG CGG GCG TTG GCG GGG GGT GAT CCG GAC GCG GGT GTG 2465 Ala Gly Arg Leu Arg Ala Leu Ala Gly Gly Asp Pro Asp Ala Gly Val 535 540 545 550 GTC ACC GGT GCG GTT CTC GAC GGT GGT GTG GTT GTC GGT GCT GCC CCC 2513 Val Thr Gly Ala Val Leu Asp Gly Gly Val Val Val Gly Ala Ala Pro 555 560 565 GGC GGT GCC GGT GCT GCC GGT GGT GCC GGT GCT GCC GGT GGT GCC GGT 2561 Gly Gly Ala Gly Ala Ala Gly Gly Ala Gly Ala Ala Gly Gly Ala Gly 570 575 580 GGT GGG GGC GTG GTG TTG GTT TTC CCT GGT CAG GGG ACG CAG TGG GTG 2609 Gly Gly Gly Val Val Leu Val Phe Pro Gly Gln Gly Thr Gln Trp Val 585 590 595 GGG ATG GGT GCG GGG CTG CTG GGG TCT TCG GAG GTG TTT GCG GCG TCG 2657 Gly Met Gly Ala Gly Leu Leu Gly Ser Ser Glu Val Phe Ala Ala Ser 600 605 610 ATG CGG GAG TGT GCG CGG GCG CTG AGT GTT CAT GTG GGG TGG GAT TTG 2705 Met Arg Glu Cys Ala Arg Ala Leu Ser Val His Val Gly Trp Asp Leu 615 620 625 630 CTG GAG GTG GTG TCG GGC GGG GCC GGG TTG GAG CGG GTG GAT GTG GTG 2753 Leu Glu Val Val Ser Gly Gly Ala Gly Leu Glu Arg Val Asp Val Val 635 640 645 CAG CCG GTG ACG TGG GCG GTG ATG GTG TCG CTG GCC CGG TAC TGG CAG 2801 Gln Pro Val Thr Trp Ala Val Met Val Ser Leu Ala Arg Tyr Trp Gln 650 655 660 GCG ATG GGT GTG GAC GTG GCT GCG GTG GTG GGT CAT TCC CAG GGG GAG 2849 Ala Met Gly Val Asp Val Ala Ala Val Val Gly His Ser Gln Gly Glu 665 670 675 ATC GCC GCT GCC ACG GTG GCG GGG GCG TTG TCG CTG GAG GAT GCG GCG 2897 Ile Ala Ala Ala Thr Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala 680 685 690 GCT GTG GTC GCT CTG CGG GCG GGG TTG ATT GGC CGG TAT CTG GCG GGT 2945 Ala Val Val Ala Leu Arg Ala Gly Leu Ile Gly Arg Tyr Leu Ala Gly 695 700 705 710 CGT GGT GCG ATG GCG GCT GTT CCG CTG CCT GCC GGC GAG GTC GAG GCC 2993 Arg Gly Ala Met Ala Ala Val Pro Leu Pro Ala Gly Glu Val Glu Ala 715 720 725 GGG CTG GCG AAG TGG CCG GGT GTG GAG GTC GCG GCG GTC AAC GGT CCG 3041 Gly Leu Ala Lys Trp Pro Gly Val Glu Val Ala Ala Val Asn Gly Pro 730 735 740 GCG TCT ACG GTG GTT TCC GGG GAT CGG CGG GCG GTG GCC GGT TAT GTG 3089 Ala Ser Thr Val Val Ser Gly Asp Arg Arg Ala Val Ala Gly Tyr Val 745 750 755 GCC GTC TGT CAG GCG GAG GGT GTG CAG GCC CGG TTG ATA CCG GTG GAC 3137 Ala Val Cys Gln Ala Glu Gly Val Gln Ala Arg Leu Ile Pro Val Asp 760 765 770 TAC GCC TCT CAC TCC CGC CAT GTG GAG GAC CTG AAG GGC GAG TTG GAG 3185 Tyr Ala Ser His Ser Arg His Val Glu Asp Leu Lys Gly Glu Leu Glu 775 780 785 790 CGG GTG CTG TCC GGT ATC CGC CCC CGC AGT CCG CGG GTG CCG GTG TGT 3233 Arg Val Leu Ser Gly Ile Arg Pro Arg Ser Pro Arg Val Pro Val Cys 795 800 805 TCC ACC GTC GCC GGA GAG CAG CCG GGC GAG CCG GTT TTC GAT GCG GGG 3281 Ser Thr Val Ala Gly Glu Gln Pro Gly Glu Pro Val Phe Asp Ala Gly 810 815 820 TAT TGG TTC CGT AAT CTG CGG AAC CGG GTT GAG TTC TCC GCG GTG GTC 3329 Tyr Trp Phe Arg Asn Leu Arg Asn Arg Val Glu Phe Ser Ala Val Val 825 830 835 GGT GGT TTG TTG GAG GAG GGC CAC CGT CGG TTC ATC GAG GTC AGT GCC 3377 Gly Gly Leu Leu Glu Glu Gly His Arg Arg Phe Ile Glu Val Ser Ala 840 845 850 CAC CCG GTA CTC GTC CAT GCG ATC GAG CAG ACG GCC GAG GCC GCG GAC 3425 His Pro Val Leu Val His Ala Ile Glu Gln Thr Ala Glu Ala Ala Asp 855 860 865 870 CGG AGT GTC CAT GCC ACC GGG ACC CTG CGC CGC CAG GAC GAC AGC CCG 3473 Arg Ser Val His Ala Thr Gly Thr Leu Arg Arg Gln Asp Asp Ser Pro 875 880 885 CAC CGC CTG CTG ACC TCC ACC GCC GAG GCC TGG GCC CAC GGC GCC ACC 3521 His Arg Leu Leu Thr Ser Thr Ala Glu Ala Trp Ala His Gly Ala Thr 890 895 900 CTC ACC TGG GAC CCC GCC CTG CCC CCA GGC CAC CTC ACC ACC CTC CCC 3569 Leu Thr Trp Asp Pro Ala Leu Pro Pro Gly His Leu Thr Thr Leu Pro 905 910 915 ACC TAC CCC TTC AAC CAC CAC CAC TAC TGG CTC GAC ACC ATT GAC GGG 3617 Thr Tyr Pro Phe Asn His His His Tyr Trp Leu Asp Thr Ile Asp Gly 920 925 930 GGC GGA GGG GAC GAC GCG ACC CAG GAG AAG GAG AGC GGC CCT CTG ACG 3665 Gly Gly Gly Asp Asp Ala Thr Gln Glu Lys Glu Ser Gly Pro Leu Thr 935 940 945 950 CGG GAA CTG CGT GGG CTG CCG TCC TCT CAG AAG CAA CTG GGT TTC CTG 3713 Arg Glu Leu Arg Gly Leu Pro Ser Ser Gln Lys Gln Leu Gly Phe Leu 955 960 965 CTC GAT CTG GTG TGC CGG CAC ACG GCC GTC GTA CTC GGC CTG GAC ACG 3761 Leu Asp Leu Val Cys Arg His Thr Ala Val Val Leu Gly Leu Asp Thr 970 975 980 GCC GCC GAG GTG GAC CCG GAC CTG TCC TTC AAG AAG CAG GGC ATC CAG 3809 Ala Ala Glu Val Asp Pro Asp Leu Ser Phe Lys Lys Gln Gly Ile Gln 985 990 995 TCC ATG ACC GGC GTC GAG CTG CGC AAC AGG CTG CTG ACC GAG ACC GGC 3857 Ser Met Thr Gly Val Glu Leu Arg Asn Arg Leu Leu Thr Glu Thr Gly 1000 1005 1010 CTG GCA TTG CCC ACC ACC CTC GTC TAC GAC CGG CCC ACC CCT CGC GCC 3905 Leu Ala Leu Pro Thr Thr Leu Val Tyr Asp Arg Pro Thr Pro Arg Ala 1015 1020 1025 1030 CTG GCG CAG TTC CTC CAC ACC GAG TTG CTC GAC GGC TCC CCC TCG GGC 3953 Leu Ala Gln Phe Leu His Thr Glu Leu Leu Asp Gly Ser Pro Ser Gly 1035 1040 1045 TCC GTC CTC GCA CCG GCG CAG AAG AGC TTC GAA GCC CAG GAG CCG ATC 4001 Ser Val Leu Ala Pro Ala Gln Lys Ser Phe Glu Ala Gln Glu Pro Ile 1050 1055 1060 GCG GTG GTG GGT ATG GGG TGC CGG TTC CCC GGT GGG GTG GGT TCG CCG 4049 Ala Val Val Gly Met Gly Cys Arg Phe Pro Gly Gly Val Gly Ser Pro 1065 1070 1075 GAG GCG TTG TGG CGG TTG GTG GTG GAG GGG GTG GAC GCG GTT TCC CCG 4097 Glu Ala Leu Trp Arg Leu Val Val Glu Gly Val Asp Ala Val Ser Pro 1080 1085 1090 TTT CCC GGT GAT CGT GGC TGG GAT GTG GAG GGG TTG TAC GAC CCG GAG 4145 Phe Pro Gly Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr Asp Pro Glu 1095 1100 1105 1110 CCG GGT GTG GCG GGG AAG TCG TAT GTG CGG GAG GGG GGT TTT CTG CAT 4193 Pro Gly Val Ala Gly Lys Ser Tyr Val Arg Glu Gly Gly Phe Leu His 1115 1120 1125 GAT GCG GCG GAG TTC GAT GCG GAG TTC TTC GGG ATT TCG CCG CGT GAG 4241 Asp Ala Ala Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu 1130 1135 1140 GCG GTG GCG ATG GAT CCG CAG CAG CGG CTG TTG CTG GAG ACC TCC TGG 4289 Ala Val Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp 1145 1150 1155 GAG GCG ATC GAG CGG GCG GGT ATC GAC CCG CAC TCG CTG CAC GGC AGC 4337 Glu Ala Ile Glu Arg Ala Gly Ile Asp Pro His Ser Leu His Gly Ser 1160 1165 1170 CGC ACC GGC GTC TAC GCC GGC GTG ATG CCG CAG GAA TAC GGA CCT CGG 4385 Arg Thr Gly Val Tyr Ala Gly Val Met Pro Gln Glu Tyr Gly Pro Arg 1175 1180 1185 1190 CTC GCC GAA GGA GCG GAA GGC AGC GAC GGC TAC CTC CTC ACC GGT ACG 4433 Leu Ala Glu Gly Ala Glu Gly Ser Asp Gly Tyr Leu Leu Thr Gly Thr 1195 1200 1205 TCG GGG AGT GTG GTG TCG GGG CGT GTG GCC TAC ACG CTG GGG CTG GAG 4481 Ser Gly Ser Val Val Ser Gly Arg Val Ala Tyr Thr Leu Gly Leu Glu 1210 1215 1220 GGT CCG GCC GTG ACC GTG GAT ACG GCG TGT TCG TCG TCG TTG GTG GCG 4529 Gly Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala 1225 1230 1235 TTG CAT CTG GCG GTG CAG GCG TTG CGG GGT GGC GAG TGT GAC ATG GCG 4577 Leu His Leu Ala Val Gln Ala Leu Arg Gly Gly Glu Cys Asp Met Ala 1240 1245 1250 TTG GCC GGT GGT GTG ACG GTG ATG GCC GGG CCG GGG ATG TTC GTG GAG 4625 Leu Ala Gly Gly Val Thr Val Met Ala Gly Pro Gly Met Phe Val Glu 1255 1260 1265 1270 TTT TCG CGG CAG CGG GGG TTG GCG GCC GAT GGG CGG TGC AAG GCG TTC 4673 Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe 1275 1280 1285 GCG GAT GGG GCG GAT GGG ACC GCT TGG GCC GAG GGT GCG GGG GTG GTG 4721 Ala Asp Gly Ala Asp Gly Thr Ala Trp Ala Glu Gly Ala Gly Val Val 1290 1295 1300 CTG GTG GAG CGG TTG TCG GAT GCC CGG CGG TTG GGG CAT CCG GTG TTG 4769 Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Pro Val Leu 1305 1310 1315 GCG GTG GTG TGT GGG TCG GCG GTG AAT CAG GAC GGT GCG TCG AAT GGT 4817 Ala Val Val Cys Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 1320 1325 1330 TTG ACG GCG CCG AGT GGT CCG TCG CAG GAG CGG GTG ATT CGT CAG GCG 4865 Leu Thr Ala Pro Ser Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala 1335 1340 1345 1350 TTG GGG AAT GCG CGG TTG ACG GTG GCG GAT GTG GAT GTG GTG GAG GCG 4913 Leu Gly Asn Ala Arg Leu Thr Val Ala Asp Val Asp Val Val Glu Ala 1355 1360 1365 CAT GGG ACG GGG ACG CGG CTG GGT GAT CCG ATC GAG GCG CAG GCG TTG 4961 His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu 1370 1375 1380 CTG GGG ACG TAT GGG CGG GAT CGT GAT GGT GGG CGT CCG GTG TGG TTG 5009 Leu Gly Thr Tyr Gly Arg Asp Arg Asp Gly Gly Arg Pro Val Trp Leu 1385 1390 1395 GGG TCG TTG AAG TCG AAT ATT GGT CAT GCT CAG GCG GCT GCG GGG GTG 5057 Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val 1400 1405 1410 GCT GGT GTG ATC AAG ATG GTG TTG GCG ATG CGG TAT GGG TGG TTG CCG 5105 Ala Gly Val Ile Lys Met Val Leu Ala Met Arg Tyr Gly Trp Leu Pro 1415 1420 1425 1430 CGG ACG TTG CAT GTG GAT GAG CCG AGC CGG CAT GTG GAC TGG TCG GCT 5153 Arg Thr Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala 1435 1440 1445 GGT GGT GTG TGG TTG CTG ACC GAG GCG CGG GAG TGG CCG GGG GTG GAC 5201 Gly Gly Val Trp Leu Leu Thr Glu Ala Arg Glu Trp Pro Gly Val Asp 1450 1455 1460 CGG CCG CGT CGG GCG GCG GTC TCC GCC TTT GGT GTC AGT GGT ACC AAC 5249 Arg Pro Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn 1465 1470 1475 GCC CAT CTG ATC CTC GAA GCC CCC GAC ACC GCC GAG GCG GAG AGC GCC 5297 Ala His Leu Ile Leu Glu Ala Pro Asp Thr Ala Glu Ala Glu Ser Ala 1480 1485 1490 ACG ACC CCG GTC CGC TCT GAG GTG TCG GAG TCT GCT GCG GTC CTC GAT 5345 Thr Thr Pro Val Arg Ser Glu Val Ser Glu Ser Ala Ala Val Leu Asp 1495 1500 1505 1510 GCC CGC AGT GGT GTG GTG CCG GTG GTG GTT TCG GGG CGT TCG CGG GTG 5393 Ala Arg Ser Gly Val Val Pro Val Val Val Ser Gly Arg Ser Arg Val 1515 1520 1525 GTG GTG CGG GAG GCT GCG GGC CGG TTG GCG GAG GTG GTG GAG GCC GGT 5441 Val Val Arg Glu Ala Ala Gly Arg Leu Ala Glu Val Val Glu Ala Gly 1530 1535 1540 GGT GTG GGG CTG GCG GAT GTG GCG GTG ACG ATG GCG GGC CGG TCG CGG 5489 Gly Val Gly Leu Ala Asp Val Ala Val Thr Met Ala Gly Arg Ser Arg 1545 1550 1555 TTT GGG TAT CGG GCG GTT GTG CTG GCT CGG GGT GAG GCT GAG CTT GCC 5537 Phe Gly Tyr Arg Ala Val Val Leu Ala Arg Gly Glu Ala Glu Leu Ala 1560 1565 1570 GGG CGT TTG CGG GCG TTG GCG GGG GGT GAT CCG GAC GCG GGT GTG GTC 5585 Gly Arg Leu Arg Ala Leu Ala Gly Gly Asp Pro Asp Ala Gly Val Val 1575 1580 1585 1590 ACC GGT GCG GTG GTG GAC CCG GAG ACG GGG TCC GGT GGT GGG GGC GTG 5633 Thr Gly Ala Val Val Asp Pro Glu Thr Gly Ser Gly Gly Gly Gly Val 1595 1600 1605 GTG TTG GTT TTC CCT GGT CAG GGG ACG CAG TGG GTG GGG ATG GGT GCG 5681 Val Leu Val Phe Pro Gly Gln Gly Thr Gln Trp Val Gly Met Gly Ala 1610 1615 1620 GGG CTG CTG GGG TCT TCG GAG GTG TTT GCG GCG TCG ATG CGG GAG TGT 5729 Gly Leu Leu Gly Ser Ser Glu Val Phe Ala Ala Ser Met Arg Glu Cys 1625 1630 1635 GCG CGG GCG CTG AGT GTT CAT GTG GAG TGG GAT TTG CTG GAG GTG GTG 5777 Ala Arg Ala Leu Ser Val His Val Glu Trp Asp Leu Leu Glu Val Val 1640 1645 1650 TCG GGC GGG GCC GGG TTG GAG CGG GTG GAT GTG GTG CAG CCC GTG ACG 5825 Ser Gly Gly Ala Gly Leu Glu Arg Val Asp Val Val Gln Pro Val Thr 1655 1660 1665 1670 TGG GCG GTG ATG GTG TCG CTG GCC CGG TAC TGG CAG GCG ATG GGT GTG 5873 Trp Ala Val Met Val Ser Leu Ala Arg Tyr Trp Gln Ala Met Gly Val 1675 1680 1685 GAC GTG GCT GCG GTG GTG GGT CAT TCC CAG GGG GAG ATC GCT GCT GCC 5921 Asp Val Ala Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala 1690 1695 1700 ACG GTG GCG GGG GCG TTG TCG CTG GAG GAT GCG GCG GCT GTG GTC GCT 5969 Thr Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Ala Val Val Ala 1705 1710 1715 CTG CGG GCG GGG TTG ATT GGC CGG TAT CTG GCG GGT CGT GGT GCG ATG 6017 Leu Arg Ala Gly Leu Ile Gly Arg Tyr Leu Ala Gly Arg Gly Ala Met 1720 1725 1730 GCG GCT GTT CCG CTG CCT GCC GGC GAG GTC GAG GCC GGG CTG GCG AAG 6065 Ala Ala Val Pro Leu Pro Ala Gly Glu Val Glu Ala Gly Leu Ala Lys 1735 1740 1745 1750 TGG CCG GGT GTG GAG GTC GCG GCG GTC AAC GGT CCG GCG TCC ACG GTG 6113 Trp Pro Gly Val Glu Val Ala Ala Val Asn Gly Pro Ala Ser Thr Val 1755 1760 1765 GTT TCC GGG GAT CGG CGG GCG GTG GCC GGT TAT GTG GCC GTC TGT CAG 6161 Val Ser Gly Asp Arg Arg Ala Val Ala Gly Tyr Val Ala Val Cys Gln 1770 1775 1780 GCG GAG GGT GTG CAG GCT CGG TTG ATA CCG GTG GAC TAC GCC TCT CAC 6209 Ala Glu Gly Val Gln Ala Arg Leu Ile Pro Val Asp Tyr Ala Ser His 1785 1790 1795 TCC CGC CAT GTG GAG GAC CTG AAG GGC GAG TTG GAG CGG GTG CTG TCC 6257 Ser Arg His Val Glu Asp Leu Lys Gly Glu Leu Glu Arg Val Leu Ser 1800 1805 1810 GGT ATC CGC CCC CGC AGT CCG CGG GTG CCG GTG TGT TCC ACC GTC GCC 6305 Gly Ile Arg Pro Arg Ser Pro Arg Val Pro Val Cys Ser Thr Val Ala 1815 1820 1825 1830 GGA GAG CAG CCG GGC GAG CCG GTT TTC GAT GCG GGG TAT TGG TTC CGT 6353 Gly Glu Gln Pro Gly Glu Pro Val Phe Asp Ala Gly Tyr Trp Phe Arg 1835 1840 1845 AAT CTG CGG AAC CGG GTT GAG TTC TCC GCG GTG GTC GGT GGT TTG TTG 6401 Asn Leu Arg Asn Arg Val Glu Phe Ser Ala Val Val Gly Gly Leu Leu 1850 1855 1860 GAG GAG GGC CAC CGT CGG TTC ATC GAG GTC AGT GCC CAC CCG GTA CTC 6449 Glu Glu Gly His Arg Arg Phe Ile Glu Val Ser Ala His Pro Val Leu 1865 1870 1875 GTC CAT GCG ATC GAG CAG ACG GCC GAG GCC GCG GAC CGG AGT GTC CAT 6497 Val His Ala Ile Glu Gln Thr Ala Glu Ala Ala Asp Arg Ser Val His 1880 1885 1890 GCC ACC GGG ACC CTG CGC CGC CAG GAC GAC AGC CCG CAC CGC CTG CTG 6545 Ala Thr Gly Thr Leu Arg Arg Gln Asp Asp Ser Pro His Arg Leu Leu 1895 1900 1905 1910 ACC TCC ACC GCC GAG GCC TGG GCC CAC GGC GCC ACC CTC ACC TGG GAC 6593 Thr Ser Thr Ala Glu Ala Trp Ala His Gly Ala Thr Leu Thr Trp Asp 1915 1920 1925 CCC GCC CTG CCC CCA GGC CAC CTC ACC ACC CTC CCC ACC TAC CCC TTC 6641 Pro Ala Leu Pro Pro Gly His Leu Thr Thr Leu Pro Thr Tyr Pro Phe 1930 1935 1940 AAC CAC CAC CAC TAC TGG CTC GAC ACC ACC CCC ACC ACC CCC GCG ACG 6689 Asn His His His Tyr Trp Leu Asp Thr Thr Pro Thr Thr Pro Ala Thr 1945 1950 1955 ACC ACC CAG AGC CCC ACC GAT GCC TGG CGC TAC CGC GTC ACC TGG AAA 6737 Thr Thr Gln Ser Pro Thr Asp Ala Trp Arg Tyr Arg Val Thr Trp Lys 1960 1965 1970 GCC CTG ACC GAA TCC TCC CCC GTC CGC CCT CAC TCC ATC GGT CGC TGC 6785 Ala Leu Thr Glu Ser Ser Pro Val Arg Pro His Ser Ile Gly Arg Cys 1975 1980 1985 1990 CTC CTC GTT GCA CCC CCG ACC ACC GAC GGC GAG CTC CTC GAC GGA CTG 6833 Leu Leu Val Ala Pro Pro Thr Thr Asp Gly Glu Leu Leu Asp Gly Leu 1995 2000 2005 ACA ACG GTG TTG TCC GAG CGC GGT GCC TCC GTC GCC CGC CTT GAG GTG 6881 Thr Thr Val Leu Ser Glu Arg Gly Ala Ser Val Ala Arg Leu Glu Val 2010 2015 2020 CCC ATC GGC GCG CGG CGT GCC GAG GTC GCC GAA CTG CTC AAG CCC TCC 6929 Pro Ile Gly Ala Arg Arg Ala Glu Val Ala Glu Leu Leu Lys Pro Ser 2025 2030 2035 ATG GAG TCA GCG GGG GAG GAG AAC ACC ACC GTC GTC TCG CTT CTC GGT 6977 Met Glu Ser Ala Gly Glu Glu Asn Thr Thr Val Val Ser Leu Leu Gly 2040 2045 2050 CTG GTG CCC TCC ACG GAC GCG GTC AGG ACG TCG ATA GCG CTC CTC CAG 7025 Leu Val Pro Ser Thr Asp Ala Val Arg Thr Ser Ile Ala Leu Leu Gln 2055 2060 2065 2070 GCG GTC TCC GAC ATC GGC GTC CCG GCC GCC AGG GTC TGG GCG CTG ACG 7073 Ala Val Ser Asp Ile Gly Val Pro Ala Ala Arg Val Trp Ala Leu Thr 2075 2080 2085 CGG AGG GCC GTG GCC GTG GTT CCC GGG GAG ACG CCG CAG GAC GCG GGG 7121 Arg Arg Ala Val Ala Val Val Pro Gly Glu Thr Pro Gln Asp Ala Gly 2090 2095 2100 GCC CAG TTG TGG GGC TTC GGA CGA GTG GCG GCC CTT GAA CTC CCG GAT 7169 Ala Gln Leu Trp Gly Phe Gly Arg Val Ala Ala Leu Glu Leu Pro Asp 2105 2110 2115 ATC TGG GGC GGC TTG ATC GAT CTG CCG GAG ACA GCG GAG CTG ACG CGG 7217 Ile Trp Gly Gly Leu Ile Asp Leu Pro Glu Thr Ala Glu Leu Thr Arg 2120 2125 2130 ACG CCG GAG ACC TCA CAG CCC CCA CAG ACC CCG GAG AGG CTG CCG CAG 7265 Thr Pro Glu Thr Ser Gln Pro Pro Gln Thr Pro Glu Arg Leu Pro Gln 2135 2140 2145 2150 ACT CCG AAC CGA CGC GCC CTT GAG CTT GCT GCC GCC GTC CTC GCC GGC 7313 Thr Pro Asn Arg Arg Ala Leu Glu Leu Ala Ala Ala Val Leu Ala Gly 2155 2160 2165 CGC GAC GGC GAG GAC CAG GTC GCC GTG CGC GCC TCG GGG ATC TAC GGG 7361 Arg Asp Gly Glu Asp Gln Val Ala Val Arg Ala Ser Gly Ile Tyr Gly 2170 2175 2180 CGG CGG GTG TCG CGG GCC GCG GCA GCG GGG GCC GCC TCC TGG CAG CCG 7409 Arg Arg Val Ser Arg Ala Ala Ala Ala Gly Ala Ala Ser Trp Gln Pro 2185 2190 2195 TCC GGC ACG GTG CTG ATC ACC GGC GGC ATG GGT GCC ATC GGC AGG CGG 7457 Ser Gly Thr Val Leu Ile Thr Gly Gly Met Gly Ala Ile Gly Arg Arg 2200 2205 2210 CTC GCC CGC AGG CTG GCG GCC GAG GGA GCC GAA CGC CTG GTC CTC ACC 7505 Leu Ala Arg Arg Leu Ala Ala Glu Gly Ala Glu Arg Leu Val Leu Thr 2215 2220 2225 2230 AGC CGT CGC GGA CCG GAG GCG CCG GGC GCC GCC GAA CTC GCC GAG GAA 7553 Ser Arg Arg Gly Pro Glu Ala Pro Gly Ala Ala Glu Leu Ala Glu Glu 2235 2240 2245 CTG CGA GGA CAT GGC TGC GAG GTC GTG CAC GCG GCC TGT GAC GTG GCC 7601 Leu Arg Gly His Gly Cys Glu Val Val His Ala Ala Cys Asp Val Ala 2250 2255 2260 GAG CGT GAT GCG CTC GCC GCG CTC GTC ACC GCG TAT CCG CCG AAC GCC 7649 Glu Arg Asp Ala Leu Ala Ala Leu Val Thr Ala Tyr Pro Pro Asn Ala 2265 2270 2275 GTC TTC CAC ACC GCC GGG ATT CTG GAC GAC GCG GTG ATC GAC ACG CTG 7697 Val Phe His Thr Ala Gly Ile Leu Asp Asp Ala Val Ile Asp Thr Leu 2280 2285 2290 TCA CCG GAG AGC TTC GAG ACC GTC CGC GGG GCG AAG GTG TGC GGC GCG 7745 Ser Pro Glu Ser Phe Glu Thr Val Arg Gly Ala Lys Val Cys Gly Ala 2295 2300 2305 2310 GAG CTG CTG CAC CAA CTG ACT GCG GAC ATA AAA GGG TTG GAC GCC TTC 7793 Glu Leu Leu His Gln Leu Thr Ala Asp Ile Lys Gly Leu Asp Ala Phe 2315 2320 2325 GTC CTC TTC TCC TCC GTC ACC GGC ACA TGG GGC AAC GCC GGC CAG GGT 7841 Val Leu Phe Ser Ser Val Thr Gly Thr Trp Gly Asn Ala Gly Gln Gly 2330 2335 2340 GCG TAC GCC GCC GCC AAC GCC GCG CTC GAC GCC CTC GCC GAG CGT CGC 7889 Ala Tyr Ala Ala Ala Asn Ala Ala Leu Asp Ala Leu Ala Glu Arg Arg 2345 2350 2355 CGT GCC GCC GGA CTG CCC GCG ACC TCC GTC GCC TGG GGC CTT TGG GGC 7937 Arg Ala Ala Gly Leu Pro Ala Thr Ser Val Ala Trp Gly Leu Trp Gly 2360 2365 2370 GGG GGA GGC ATG GCG GCG GGT GCG GGC GAG GAG AGT CTG TCG CGG CGA 7985 Gly Gly Gly Met Ala Ala Gly Ala Gly Glu Glu Ser Leu Ser Arg Arg 2375 2380 2385 2390 GGG CTG CGG GCC ATG GAC CCC GAC GCG GCC GTC GAC GCG CTC CTG GGC 8033 Gly Leu Arg Ala Met Asp Pro Asp Ala Ala Val Asp Ala Leu Leu Gly 2395 2400 2405 GCC ATG GGC AGG AAC GAC GTG TGC GTC ACT GTC GTC GAC GTC GAC TGG 8081 Ala Met Gly Arg Asn Asp Val Cys Val Thr Val Val Asp Val Asp Trp 2410 2415 2420 GAG CGT TTC GCG CCC GCG ACG AAC GCC ATC CGT CCC GGG CGG CTG TTC 8129 Glu Arg Phe Ala Pro Ala Thr Asn Ala Ile Arg Pro Gly Arg Leu Phe 2425 2430 2435 GAC ACC GTG CCG GAG GCG CGG GAG GCC CTG ACG GCA GCC GGC ACC ACG 8177 Asp Thr Val Pro Glu Ala Arg Glu Ala Leu Thr Ala Ala Gly Thr Thr 2440 2445 2450 TCC GCG ACG CCG GAC GGC GCG CCC GAG CTG GCG CGG CGG TTG TCC ATG 8225 Ser Ala Thr Pro Asp Gly Ala Pro Glu Leu Ala Arg Arg Leu Ser Met 2455 2460 2465 2470 CTG AAC GAG ACC GAA CGC CTG CGG AAG CTG GTC GAA CTC GTC CGT ACC 8273 Leu Asn Glu Thr Glu Arg Leu Arg Lys Leu Val Glu Leu Val Arg Thr 2475 2480 2485 GAG GCG GCC TTT GTG CTG CGG CAT CCG AAC ACG GAC GCC ATC GGC GCC 8321 Glu Ala Ala Phe Val Leu Arg His Pro Asn Thr Asp Ala Ile Gly Ala 2490 2495 2500 GAA CGC CCG TTC AAG TCG GCC GGT TTC GAC TCC CTG ACC TCC CTG GAA 8369 Glu Arg Pro Phe Lys Ser Ala Gly Phe Asp Ser Leu Thr Ser Leu Glu 2505 2510 2515 CTC CGC AAC CGC CTC AAT GCC GGC ACA GGC CTG AAG CTA CCC GCC ACC 8417 Leu Arg Asn Arg Leu Asn Ala Gly Thr Gly Leu Lys Leu Pro Ala Thr 2520 2525 2530 GTC ATC TTC GAC CAC CCC AGC CCG ACC GCC CTG GCC AGA CTG CTG CTC 8465 Val Ile Phe Asp His Pro Ser Pro Thr Ala Leu Ala Arg Leu Leu Leu 2535 2540 2545 2550 GAC CGG CTG ACC GGC GCC GGA GCC CCC GCG CCC GCC GCC GAT GAG CCG 8513 Asp Arg Leu Thr Gly Ala Gly Ala Pro Ala Pro Ala Ala Asp Glu Pro 2555 2560 2565 CCA CTG CCC GTC GCC GTG GCC GAC GAC GAC CCG GTG GTC ATC GTC GGC 8561 Pro Leu Pro Val Ala Val Ala Asp Asp Asp Pro Val Val Ile Val Gly 2570 2575 2580 ATG GCG TGC CGT TTC CCC GGT GGG GCG GGC ACC CCT GAG GCG CTG TGG 8609 Met Ala Cys Arg Phe Pro Gly Gly Ala Gly Thr Pro Glu Ala Leu Trp 2585 2590 2595 AAG CTG GTG ACC GAG GAG CGT GAC GTC ATA GGC GCC GCG CCC ACC GAC 8657 Lys Leu Val Thr Glu Glu Arg Asp Val Ile Gly Ala Ala Pro Thr Asp 2600 2605 2610 CGG GGC TGG GAC CTG GAT TCC GTC TAC GAC CCG GAG CCG GGT GTG GCG 8705 Arg Gly Trp Asp Leu Asp Ser Val Tyr Asp Pro Glu Pro Gly Val Ala 2615 2620 2625 2630 GGG AAG ACA TAT GTG CGG GAG GGG GGT TTT CTC CAC GAC GCG GCG GAG 8753 Gly Lys Thr Tyr Val Arg Glu Gly Gly Phe Leu His Asp Ala Ala Glu 2635 2640 2645 TTC GAC GCG GAG TTC TTC GGG ATT TCG CCG CGT GAG GCG GTG GCG ATG 8801 Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Val Ala Met 2650 2655 2660 GAT CCG CAG CAG CGG CTG TTG CTG GAG ACC TCC TGG GAG GCG ATC GAG 8849 Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala Ile Glu 2665 2670 2675 CGG GCG GGT ATC GAC CCG CAC TCG CTG CAC GGC AGC CGC ACC GGG GTA 8897 Arg Ala Gly Ile Asp Pro His Ser Leu His Gly Ser Arg Thr Gly Val 2680 2685 2690 TAC GTC GGG CTG ACC CAT CAG GAG TAC GCC TCC CGG CTG CAC GAG GCC 8945 Tyr Val Gly Leu Thr His Gln Glu Tyr Ala Ser Arg Leu His Glu Ala 2695 2700 2705 2710 CCG GAG GAG TAC GAA GGC TAT CTG CTC ACC GGC AAG TCG GCG AGC GTC 8993 Pro Glu Glu Tyr Glu Gly Tyr Leu Leu Thr Gly Lys Ser Ala Ser Val 2715 2720 2725 GTC TCC GGC CGC ATC TCG TAC ACG CTG GGG CTG GAG GGT CCT TCG CTC 9041 Val Ser Gly Arg Ile Ser Tyr Thr Leu Gly Leu Glu Gly Pro Ser Leu 2730 2735 2740 TCC ATC GAC ACC GCG TGT TCG TCG TCG CTG GTC GCC CTG CAC AAC GCG 9089 Ser Ile Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Asn Ala 2745 2750 2755 GCG CAG GCG TTG CGG GGT GGC GAG TGT GAC ATG GCG TTG GCC GGT GGT 9137 Ala Gln Ala Leu Arg Gly Gly Glu Cys Asp Met Ala Leu Ala Gly Gly 2760 2765 2770 GTG ACG GTG ATG GCG GCA CCC GGA TTG TTC GTG GAG TTT TCG CGG CAG 9185 Val Thr Val Met Ala Ala Pro Gly Leu Phe Val Glu Phe Ser Arg Gln 2775 2780 2785 2790 CGG GGG TTG GCG GCC GAT GGG CGG TGC AAG GCG TTC GCG GAT GGG GCG 9233 Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Gly Ala 2795 2800 2805 GAT GGG ACC GCT TGG GCC GAG GGT GCG GGG GTG GTG CTG GTG GAG CGG 9281 Asp Gly Thr Ala Trp Ala Glu Gly Ala Gly Val Val Leu Val Glu Arg 2810 2815 2820 TTG TCG GAT GCC CGG CGG TTG GGG CAT CCG GTG TTG GCG GTG GTG TGT 9329 Leu Ser Asp Ala Arg Arg Leu Gly His Pro Val Leu Ala Val Val Cys 2825 2830 2835 GGG TCG GCG GTG AAT CAG GAC GGT GCG TCG AAT GGT TTG ACG GCG CCG 9377 Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 2840 2845 2850 AGT GGT CCG TCG CAG GAG CGG GTG ATT CGT CAG GCG TTG GCG AAT GCG 9425 Ser Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 2855 2860 2865 2870 CGG TTG ACG GTG GCG GAT GTG GAT GTG GTG GAG GCG CAT GGG ACG GGG 9473 Arg Leu Thr Val Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 2875 2880 2885 ACG CGG CTG GGT GAT CCG ATC GAG GCG CAG GCG TTG CTG GGG ACG TAT 9521 Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Gly Thr Tyr 2890 2895 2900 GGG CGG GAT CGT GAT GCT GAG TGT CCG GTG TGG TTG GGG TCG TTG AAG 9569 Gly Arg Asp Arg Asp Ala Glu Cys Pro Val Trp Leu Gly Ser Leu Lys 2905 2910 2915 TCG AAT ATT GGT CAT GCT CAG GCG GCT GCG GGG GTG GCT GGT GTG ATC 9617 Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ala Gly Val Ile 2920 2925 2930 AAG ATG GTG TTG GCG ATG CGG TAT GGG TGG TTG CCG CGG ACG TTG CAT 9665 Lys Met Val Leu Ala Met Arg Tyr Gly Trp Leu Pro Arg Thr Leu His 2935 2940 2945 2950 GTG GAT GAG CCG AGC CGG CAT GTG GAC TGG TCG GCT GGT GGT GTG CGG 9713 Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Gly Val Arg 2955 2960 2965 TTG CTG ACC GAG GCG CGG GAG TGG CCG GGG GTG GAC CGG CCG CGT CGG 9761 Leu Leu Thr Glu Ala Arg Glu Trp Pro Gly Val Asp Arg Pro Arg Arg 2970 2975 2980 GCG GCG GTC TCC GCC TTC GGT GTC AGT GGT ACC AAC GCC CAT CTG ATC 9809 Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Leu Ile 2985 2990 2995 CTC GAA GCC CCC GAA GCC CTC GAA GCC CTC GAA GCC ACC GAC GCC CCC 9857 Leu Glu Ala Pro Glu Ala Leu Glu Ala Leu Glu Ala Thr Asp Ala Pro 3000 3005 3010 GAA GCC CCC GAA GCC CCC GAA GCC CCC GAC GTC ACC GAC GTC ACC GAA 9905 Glu Ala Pro Glu Ala Pro Glu Ala Pro Asp Val Thr Asp Val Thr Glu 3015 3020 3025 3030 GCC CTC GAA GCC CCC GAC GCC ACC GAG GCG GAG GGT GCG AAG GCT CCT 9953 Ala Leu Glu Ala Pro Asp Ala Thr Glu Ala Glu Gly Ala Lys Ala Pro 3035 3040 3045 GGC AGT CCC GAA GAG GCA CAG CCT GCT GTG GGT GTG GTG CCG GTG GTG 10001 Gly Ser Pro Glu Glu Ala Gln Pro Ala Val Gly Val Val Pro Val Val 3050 3055 3060 GTT TCG GGG CGT TCG CGG GTG GTG GTG CGG GAG GCT GCG GGC CGG TTG 10049 Val Ser Gly Arg Ser Arg Val Val Val Arg Glu Ala Ala Gly Arg Leu 3065 3070 3075 GCG GAG GTG GTG GAG GCC GGT GGT GTG GGG CTG GCG GAT GTG GCG GTG 10097 Ala Glu Val Val Glu Ala Gly Gly Val Gly Leu Ala Asp Val Ala Val 3080 3085 3090 ACG ATG GCG GGC CGG TCG CGG TTT GGG TAT CGG GCG GTT GTG CTG GCT 10145 Thr Met Ala Gly Arg Ser Arg Phe Gly Tyr Arg Ala Val Val Leu Ala 3095 3100 3105 3110 CGG GGT GAG GCT GAG CTT GCC GGG CGT TTG CGG GCG TTG GCG GGG GGT 10193 Arg Gly Glu Ala Glu Leu Ala Gly Arg Leu Arg Ala Leu Ala Gly Gly 3115 3120 3125 GAT CCG GAC GCG GGT GTG GTC ACC GGT GCG GTG GTG GAC CCG GAG ACG 10241 Asp Pro Asp Ala Gly Val Val Thr Gly Ala Val Val Asp Pro Glu Thr 3130 3135 3140 GGG TCC GGT GGT GGG GGC GTG GTG TTG GTT TTC CCT GGT CAG GGG ACG 10289 Gly Ser Gly Gly Gly Gly Val Val Leu Val Phe Pro Gly Gln Gly Thr 3145 3150 3155 CAG TGG GTG GGG ATG GGT GCG GGG CTG CTG GGG TCT TCG GAG GTG TTT 10337 Gln Trp Val Gly Met Gly Ala Gly Leu Leu Gly Ser Ser Glu Val Phe 3160 3165 3170 GCG GCG TCG ATG CGG GAG TGT GCG CGG GCG CTG AGT GTT CAT GTG GAG 10385 Ala Ala Ser Met Arg Glu Cys Ala Arg Ala Leu Ser Val His Val Glu 3175 3180 3185 3190 TGG GAT TTG CTG GAG GTG GTG TCG GGC GGG GCC GGG TTG GAG CGG GTG 10433 Trp Asp Leu Leu Glu Val Val Ser Gly Gly Ala Gly Leu Glu Arg Val 3195 3200 3205 GAT GTG GTG CAG CCC GTG ACG TGG GCG GTG ATG GTG TCG CTG GCC CGG 10481 Asp Val Val Gln Pro Val Thr Trp Ala Val Met Val Ser Leu Ala Arg 3210 3215 3220 TAC TGG CAG GCG ATG GGT GTG GAC GTG GCT GCG GTG GTG GGT CAT TCC 10529 Tyr Trp Gln Ala Met Gly Val Asp Val Ala Ala Val Val Gly His Ser 3225 3230 3235 CAG GGG GAG ATC GCT GCT GCC ACG GTG GCG GGG GCG TTG TCG CTG GAG 10577 Gln Gly Glu Ile Ala Ala Ala Thr Val Ala Gly Ala Leu Ser Leu Glu 3240 3245 3250 GAT GCG GCG GCT GTG GTC GCT CTG CGG GCG GGG TTG ATT GGC CGG TAT 10625 Asp Ala Ala Ala Val Val Ala Leu Arg Ala Gly Leu Ile Gly Arg Tyr 3255 3260 3265 3270 CTG GCG GGT CGT GGT GCG ATG GCG GCT GTT CCG CTG CCT GCC GGC GAG 10673 Leu Ala Gly Arg Gly Ala Met Ala Ala Val Pro Leu Pro Ala Gly Glu 3275 3280 3285 GTC GAG GCC GGG CTG GCG AAG TGG CCC GGA GTA CAG GTA GCC GCG GTC 10721 Val Glu Ala Gly Leu Ala Lys Trp Pro Gly Val Gln Val Ala Ala Val 3290 3295 3300 AAC GGT CCG GCG TCC ACG GTG GTT TCC GGG GAT CGG CGG GCG GTG GCC 10769 Asn Gly Pro Ala Ser Thr Val Val Ser Gly Asp Arg Arg Ala Val Ala 3305 3310 3315 GGT TAT GTG GCC GTC TGT CAG GCG GAG GGT GTG CAG GCT CGG TTG ATA 10817 Gly Tyr Val Ala Val Cys Gln Ala Glu Gly Val Gln Ala Arg Leu Ile 3320 3325 3330 CCG GTG GAC TAC GCC TCT CAC TCC CGC CAT GTG GAG GAC CTG AAG GGC 10865 Pro Val Asp Tyr Ala Ser His Ser Arg His Val Glu Asp Leu Lys Gly 3335 3340 3345 3350 GAG TTG GAG CGG GTG CTG TCC GGT ATC CGC CCC CGC AGT CCG CGG GTG 10913 Glu Leu Glu Arg Val Leu Ser Gly Ile Arg Pro Arg Ser Pro Arg Val 3355 3360 3365 CCG GTG TGT TCC ACC GTC GCC GGA GAG CAG CCG GGC GAG CCG GTT TTC 10961 Pro Val Cys Ser Thr Val Ala Gly Glu Gln Pro Gly Glu Pro Val Phe 3370 3375 3380 GAT GCG GGG TAT TGG TTC CGT AAT CTG CGG AAC CGG GTT GAG TTC TCC 11009 Asp Ala Gly Tyr Trp Phe Arg Asn Leu Arg Asn Arg Val Glu Phe Ser 3385 3390 3395 GCG GTG GTC GGT GGT TTG TTG GAG CAG GGC CAC CGT CGG TTC ATC GAG 11057 Ala Val Val Gly Gly Leu Leu Glu Gln Gly His Arg Arg Phe Ile Glu 3400 3405 3410 GTC AGT GCC CAC CCG GTA CTC GTC CAT GCC ATT GAG CAG ACG GCC GAG 11105 Val Ser Ala His Pro Val Leu Val His Ala Ile Glu Gln Thr Ala Glu 3415 3420 3425 3430 GCC GCG GAC CGG AGT GTC CAT GCC ACC GGA ACC CTG CGC CGC CAG GAC 11153 Ala Ala Asp Arg Ser Val His Ala Thr Gly Thr Leu Arg Arg Gln Asp 3435 3440 3445 GAC AGC CCG CAC CGC CTG CTG ACC TCC ACC GCC GAG GCC TGG GCC CAC 11201 Asp Ser Pro His Arg Leu Leu Thr Ser Thr Ala Glu Ala Trp Ala His 3450 3455 3460 GGC GCC ACC CTC ACC TGG GAC CCC GCC CTG CCC CCA GGT CAC CTC ACC 11249 Gly Ala Thr Leu Thr Trp Asp Pro Ala Leu Pro Pro Gly His Leu Thr 3465 3470 3475 ACC CTC CCC ACC TAC CCC TTC AAC CAC CAC CAC TAC TGG GCC GTG ACA 11297 Thr Leu Pro Thr Tyr Pro Phe Asn His His His Tyr Trp Ala Val Thr 3480 3485 3490 TCC CCC GCC GGA GTC GGC GAC GCG GCT GCG GGC CGG TTC GGT ATG ACC 11345 Ser Pro Ala Gly Val Gly Asp Ala Ala Ala Gly Arg Phe Gly Met Thr 3495 3500 3505 3510 TGG GAG GAC CAC CCC TTC CTC CGT GGC GGG TTA CCC CTG GCC GAC TCC 11393 Trp Glu Asp His Pro Phe Leu Arg Gly Gly Leu Pro Leu Ala Asp Ser 3515 3520 3525 GGT GAG CGG GTG TTC GCC GGG CGG CTG GCG GGC TCC GAG CAC GAC TGG 11441 Gly Glu Arg Val Phe Ala Gly Arg Leu Ala Gly Ser Glu His Asp Trp 3530 3535 3540 CTG ACG GAC CAT GCC GTG TCC GGG GTG ACG TTG CTG CCG GGT ACG GCC 11489 Leu Thr Asp His Ala Val Ser Gly Val Thr Leu Leu Pro Gly Thr Ala 3545 3550 3555 TTC GTG GAG TTC GCG CTG CAC GCG GGA GCC GCC ACC GGC TGC GGG CGG 11537 Phe Val Glu Phe Ala Leu His Ala Gly Ala Ala Thr Gly Cys Gly Arg 3560 3565 3570 CTG GAA GAG CTG AGC GTT GAG GCG CCG TTG GTC TTG CCC GCC GCC GGT 11585 Leu Glu Glu Leu Ser Val Glu Ala Pro Leu Val Leu Pro Ala Ala Gly 3575 3580 3585 3590 GGT GTG CGG GTG CAG ATG AGG GTG TCG GCC GCC GAC GAG TCG GGA CGG 11633 Gly Val Arg Val Gln Met Arg Val Ser Ala Ala Asp Glu Ser Gly Arg 3595 3600 3605 CGG AGG GTC GCC ATC CAC TCG GCC CCG GAA GCC GCC GTC CAC TCG GCC 11681 Arg Arg Val Ala Ile His Ser Ala Pro Glu Ala Ala Val His Ser Ala 3610 3615 3620 GCA GAA GGC GGC GAC TCG GCC GGT GTC TGG ACG CGG CAC GGC GAG GGC 11729 Ala Glu Gly Gly Asp Ser Ala Gly Val Trp Thr Arg His Gly Glu Gly 3625 3630 3635 ACG CTC GTG CCG GAC CCG GAG CCC ACG CCT CCG GAC GCC GAC TGG GCG 11777 Thr Leu Val Pro Asp Pro Glu Pro Thr Pro Pro Asp Ala Asp Trp Ala 3640 3645 3650 CGG GCC TGG CCG CCC GCC GGG GAA CGC GTC GAA CCG GCC GAG CTC TAC 11825 Arg Ala Trp Pro Pro Ala Gly Glu Arg Val Glu Pro Ala Glu Leu Tyr 3655 3660 3665 3670 GAA CGG TTC GGG GCC CTG GGC TAC GAG TAC GGT GAG GCG TTC GCG GGC 11873 Glu Arg Phe Gly Ala Leu Gly Tyr Glu Tyr Gly Glu Ala Phe Ala Gly 3675 3680 3685 GTG CGC GCC GTA TGG CGG CAG CCG GAC GCG CTG CTC GCC GAG GTG CTC 11921 Val Arg Ala Val Trp Arg Gln Pro Asp Ala Leu Leu Ala Glu Val Leu 3690 3695 3700 CTG CCC GAC CGG GCC TCG ACC GGT GCC GGC CGG TTC GGT GTG CAC CCC 11969 Leu Pro Asp Arg Ala Ser Thr Gly Ala Gly Arg Phe Gly Val His Pro 3705 3710 3715 GCG CTG CTG GAC GCG GCG CTG CAG CCG TGG ATC GCC GGT GGT CTC CTC 12017 Ala Leu Leu Asp Ala Ala Leu Gln Pro Trp Ile Ala Gly Gly Leu Leu 3720 3725 3730 GAA GTG CCG GAG GAC GCA GTG CTG CTG CCC TTC GCC TGG CAG GGA GTG 12065 Glu Val Pro Glu Asp Ala Val Leu Leu Pro Phe Ala Trp Gln Gly Val 3735 3740 3745 3750 TCG CTC TAC GCG ACG GGT GCC GGT GCT CTG CGG GTG CGG CTG ACG AAG 12113 Ser Leu Tyr Ala Thr Gly Ala Gly Ala Leu Arg Val Arg Leu Thr Lys 3755 3760 3765 GCG GGT GAC GGG GCG GTC TCG CTC CAG GCC GCA GAC ACG TCC GGC GCG 12161 Ala Gly Asp Gly Ala Val Ser Leu Gln Ala Ala Asp Thr Ser Gly Ala 3770 3775 3780 GCC GTG CTC TCC TTG GGG GCC CTG GTG ATG CGT CCG CTG GCG CGC CGG 12209 Ala Val Leu Ser Leu Gly Ala Leu Val Met Arg Pro Leu Ala Arg Arg 3785 3790 3795 AAG CTG GAC GTG CTG CTC GGC ACG GAC GCC GGC GAA CGG TCG CTG TAC 12257 Lys Leu Asp Val Leu Leu Gly Thr Asp Ala Gly Glu Arg Ser Leu Tyr 3800 3805 3810 CGC GTC GAG TGG CAG CCG CGG CTC CTG CCC GCC GGC CCG CCG CGC TCC 12305 Arg Val Glu Trp Gln Pro Arg Leu Leu Pro Ala Gly Pro Pro Arg Ser 3815 3820 3825 3830 TGG GCG GTG CTC GGC CCC GAC GCG GAC CGG CTC GCC GGG ACG CCG GGC 12353 Trp Ala Val Leu Gly Pro Asp Ala Asp Arg Leu Ala Gly Thr Pro Gly 3835 3840 3845 CTG GGG GAT CAG CCG GAC GGT GGG CCC ACC GCG CTG TAC CCG GAG GTG 12401 Leu Gly Asp Gln Pro Asp Gly Gly Pro Thr Ala Leu Tyr Pro Glu Val 3850 3855 3860 CGG GCG CTG CGG AAG GCG CTG GCG GCG GGC GCG CCG CGG CCG GAA GCG 12449 Arg Ala Leu Arg Lys Ala Leu Ala Ala Gly Ala Pro Arg Pro Glu Ala 3865 3870 3875 GTC GTA CTG CCG GTG CTC TCC GGG GCC GGG GCC ACT CCG GAG TCG GTG 12497 Val Val Leu Pro Val Leu Ser Gly Ala Gly Ala Thr Pro Glu Ser Val 3880 3885 3890 CGG CAG ACA ACG GAG CGC TGT CTG ACC GCG CTC CAG GAC TGG CTG GAC 12545 Arg Gln Thr Thr Glu Arg Cys Leu Thr Ala Leu Gln Asp Trp Leu Asp 3895 3900 3905 3910 GCC GAG GAG TTG GTG GAC ACA CCG CTC ATA GTG CTC ACC AGG GGA GCC 12593 Ala Glu Glu Leu Val Asp Thr Pro Leu Ile Val Leu Thr Arg Gly Ala 3915 3920 3925 GTC GCC GCC GTA CCG GGG GAG GAG ATC GGG GAC CTG GCG TGT GCG GGG 12641 Val Ala Ala Val Pro Gly Glu Glu Ile Gly Asp Leu Ala Cys Ala Gly 3930 3935 3940 GTG TGG GGC CTG GTG AGG TCC GCG CGG TCC GAG CAC CCG GGC CGC TTC 12689 Val Trp Gly Leu Val Arg Ser Ala Arg Ser Glu His Pro Gly Arg Phe 3945 3950 3955 GCC CTC GTC GAC ACC GAC GGG CAT CCG GAC GAC CGC ACC GCG CTG CCC 12737 Ala Leu Val Asp Thr Asp Gly His Pro Asp Asp Arg Thr Ala Leu Pro 3960 3965 3970 CTC GCG CTG CGC GCG GTC CTC GAC GGC GCC GGC CAG CTC TCC CTG CGG 12785 Leu Ala Leu Arg Ala Val Leu Asp Gly Ala Gly Gln Leu Ser Leu Arg 3975 3980 3985 3990 GCC GGC ACC GCC CGG ACC CCG GTC CTC CTC CGG GCC GGG ACC CCG GAG 12833 Ala Gly Thr Ala Arg Thr Pro Val Leu Leu Arg Ala Gly Thr Pro Glu 3995 4000 4005 GAG CAG CGG GGT CCG GCA TTC GAC CCG GCG GGC ACG GTC CTG GTG ACG 12881 Glu Gln Arg Gly Pro Ala Phe Asp Pro Ala Gly Thr Val Leu Val Thr 4010 4015 4020 GGC GCG ACC GGC ACG CTC GGG CGG CTG CTG GCC CGG CAT CTG GCC GCC 12929 Gly Ala Thr Gly Thr Leu Gly Arg Leu Leu Ala Arg His Leu Ala Ala 4025 4030 4035 GAG CAC GGT GTG CGC CAT CTG CTG CTG CTG AGC CGC GGC GGC CGG GCT 12977 Glu His Gly Val Arg His Leu Leu Leu Leu Ser Arg Gly Gly Arg Ala 4040 4045 4050 GCC GAA GGC GCG GAC GAA CTC GCC GCG GAA CTG GCC GGG TTG GAA GCC 13025 Ala Glu Gly Ala Asp Glu Leu Ala Ala Glu Leu Ala Gly Leu Glu Ala 4055 4060 4065 4070 GAG CCG TGC TTC GCG GCC TGT GAC GCG GCG GAC CGC GAG GCC CTG GCA 13073 Glu Pro Cys Phe Ala Ala Cys Asp Ala Ala Asp Arg Glu Ala Leu Ala 4075 4080 4085 CGG GTG CTG GCG GAG GTG CCG GCC GAC CGG CCG CTG ACC GGA GTG ATC 13121 Arg Val Leu Ala Glu Val Pro Ala Asp Arg Pro Leu Thr Gly Val Ile 4090 4095 4100 CAC GCG GCC GGG GTG CTC GAC GAC GGC ACA CTC GAC GCG CTG ACC CCG 13169 His Ala Ala Gly Val Leu Asp Asp Gly Thr Leu Asp Ala Leu Thr Pro 4105 4110 4115 GAA CGG ATC GGT ACC GTC ATG CGG CCG AAG GCG GAC GCG GCG CTG AAC 13217 Glu Arg Ile Gly Thr Val Met Arg Pro Lys Ala Asp Ala Ala Leu Asn 4120 4125 4130 CTG CAC GAA CTG ACC CGG ACC AGC CCG CTG TCG GTG TTC GCG GTC TTC 13265 Leu His Glu Leu Thr Arg Thr Ser Pro Leu Ser Val Phe Ala Val Phe 4135 4140 4145 4150 TCG GGC GCT GCC GGC ATC CTG GGC CGC CCC GGA CAG GCC AAC TAC GCC 13313 Ser Gly Ala Ala Gly Ile Leu Gly Arg Pro Gly Gln Ala Asn Tyr Ala 4155 4160 4165 GCC GCC AAC ACC TTC CTC GAC GCG CTC GCG CAG CAC CGC CGC GCC CAC 13361 Ala Ala Asn Thr Phe Leu Asp Ala Leu Ala Gln His Arg Arg Ala His 4170 4175 4180 GGC CTC CCC GCC GTG TCG CTG GCC TGG GGG CTG TGG GGC GGG GCG ACC 13409 Gly Leu Pro Ala Val Ser Leu Ala Trp Gly Leu Trp Gly Gly Ala Thr 4185 4190 4195 GGC ATG ACC GGC CAT CTG TCC GGC ACC GAT CTG CGC CGG ATG CGC AGG 13457 Gly Met Thr Gly His Leu Ser Gly Thr Asp Leu Arg Arg Met Arg Arg 4200 4205 4210 TCC GGT ATC GCG CCG ATG ACC CAC GAC CAG GGG CTC GCC CTG TTC GAC 13505 Ser Gly Ile Ala Pro Met Thr His Asp Gln Gly Leu Ala Leu Phe Asp 4215 4220 4225 4230 CGA GCG CTC GCC GCC TCG GCC GAG GAC CCG CTG CTC GTA CCG ATG CGG 13553 Arg Ala Leu Ala Ala Ser Ala Glu Asp Pro Leu Leu Val Pro Met Arg 4235 4240 4245 CTG GAC CTG GCC GCC CTC GTC CGG GAG CGG GCC GAG CAC GGG CCG GAC 13601 Leu Asp Leu Ala Ala Leu Val Arg Glu Arg Ala Glu His Gly Pro Asp 4250 4255 4260 GCG GTG CCC GGA CCG CTG CTC GGG CTG CTG CCC GCC CGG GCC GCG GTG 13649 Ala Val Pro Gly Pro Leu Leu Gly Leu Leu Pro Ala Arg Ala Ala Val 4265 4270 4275 CGG CAG GCG GCG GCA CCG GTA CGC GGC GGA GCC CCC GCC CCC GCC GGC 13697 Arg Gln Ala Ala Ala Pro Val Arg Gly Gly Ala Pro Ala Pro Ala Gly 4280 4285 4290 GGC GAG GGG ACG GCC GAG CGG CTG GCC GGG CTC GGG GAG GAG GCC AGG 13745 Gly Glu Gly Thr Ala Glu Arg Leu Ala Gly Leu Gly Glu Glu Ala Arg 4295 4300 4305 4310 CTG CGC GAG CTG GTG AGG CTG GTC CGC GCC GAG GTG TCG GGC GTG CTG 13793 Leu Arg Glu Leu Val Arg Leu Val Arg Ala Glu Val Ser Gly Val Leu 4315 4320 4325 GGC TAC TCG GGC CCG GAC GCG GTG GAG CCC GGG CGC CCG TTC AAG GAT 13841 Gly Tyr Ser Gly Pro Asp Ala Val Glu Pro Gly Arg Pro Phe Lys Asp 4330 4335 4340 CTC GGC TTC GAC TCG CTG ACC GCC GTG GAG CTG CGC AAC CGC CTC GGC 13889 Leu Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu Gly 4345 4350 4355 GCC GCC ACC GGG CTG CGG CTG CCG ACC GCG CTG GTC TTC GAC CGC CCG 13937 Ala Ala Thr Gly Leu Arg Leu Pro Thr Ala Leu Val Phe Asp Arg Pro 4360 4365 4370 ACG TCC CAG GCA GTG GCC GAG TAC CTC GCT GCC GAA CTG GCC GGA CCG 13985 Thr Ser Gln Ala Val Ala Glu Tyr Leu Ala Ala Glu Leu Ala Gly Pro 4375 4380 4385 4390 CGG GAC GGC GGC GAC ACC GCG GCC GCC GCG TTC GAG GGC CTG GAG GCG 14033 Arg Asp Gly Gly Asp Thr Ala Ala Ala Ala Phe Glu Gly Leu Glu Ala 4395 4400 4405 CTG GCC GCG GCG GTG GGC GCG CTG GCC GAG GAC GAT CTG CGG CGC GAC 14081 Leu Ala Ala Ala Val Gly Ala Leu Ala Glu Asp Asp Leu Arg Arg Asp 4410 4415 4420 GTG CTC CGG CGG CGA CTG ACC GAA CTG GCC GCC GCG CTC ACC CCG CAG 14129 Val Leu Arg Arg Arg Leu Thr Glu Leu Ala Ala Ala Leu Thr Pro Gln 4425 4430 4435 GGC CGG AAC CCC TCC GCG CCC GCA CCC GCC CCG TCC GAT CTG GAC GAG 14177 Gly Arg Asn Pro Ser Ala Pro Ala Pro Ala Pro Ser Asp Leu Asp Glu 4440 4445 4450 CGG CTG GAC TCC GCG AAC GAC GAC GAC CTC TTC GCC TTC ATC GAG GAG 14225 Arg Leu Asp Ser Ala Asn Asp Asp Asp Leu Phe Ala Phe Ile Glu Glu 4455 4460 4465 4470 CAG CTT TGA GCAGCGAGAA CGACAGCAGC GAGAACGACG GCGACGACAC 14274 Gln Leu * GGCCGGGGCA GCTCCGGGGA CGGCTCCGGG GGCCTCCCCC CGGCAGGACG ACCGGGTCAG 14334 GGAGTATCTG AAGCGG GTG ACC GCC GAA CTG GTC GCC ACC CGC AAG CGG 14383 Met Thr Ala Glu Leu Val Ala Thr Arg Lys Arg 1 5 10 CTC GGC GCG CTG GAG GAG CGG GCC CGC GAA CCG ATC GCC GTC GTC GCG 14431 Leu Gly Ala Leu Glu Glu Arg Ala Arg Glu Pro Ile Ala Val Val Ala 15 20 25 ATG AGC TGC CGC TAC CCG GGC GGG GTG ACG ACC CCC GAG GAC CTG TGG 14479 Met Ser Cys Arg Tyr Pro Gly Gly Val Thr Thr Pro Glu Asp Leu Trp 30 35 40 CGG CTT CTC GCG GAC GAA CGC GAC GCC GTA TCC GGA CTT CCC CGG GAC 14527 Arg Leu Leu Ala Asp Glu Arg Asp Ala Val Ser Gly Leu Pro Arg Asp 45 50 55 CGC GGC TGG GAC CTG GAC GCC CTC TAC GAC CCC GAC GGC GGC CCC GGC 14575 Arg Gly Trp Asp Leu Asp Ala Leu Tyr Asp Pro Asp Gly Gly Pro Gly 60 65 70 75 ACC AGC TAC GCC CGC GAA GGC GGC TTC CTG AGC CAC TGC GCC GGA TTC 14623 Thr Ser Tyr Ala Arg Glu Gly Gly Phe Leu Ser His Cys Ala Gly Phe 80 85 90 GAC GCG GAG TTC TTC GGC ATC TCC CCG CGC GAG GCG CTG GCG ATG GAC 14671 Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp 95 100 105 CCG CAG CAG CGG CTG CTG CTG GAG ACC TCC TGG GAG GCC CTG GAA CGC 14719 Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu Arg 110 115 120 GCC GGA GTC ACC GCC GAC CGC GCC CGG GGC AGC CGG ACG GGC GTG TAC 14767 Ala Gly Val Thr Ala Asp Arg Ala Arg Gly Ser Arg Thr Gly Val Tyr 125 130 135 GCG GGC GTC ATG TAC GAC GAC TAC GGC GCC CGG GTG CTG TAC GGC GCC 14815 Ala Gly Val Met Tyr Asp Asp Tyr Gly Ala Arg Val Leu Tyr Gly Ala 140 145 150 155 GGC GCC GGC CCG CCC GAG GAC CTG GAG GGT TAT CTC GTC AAC GGC AGC 14863 Gly Ala Gly Pro Pro Glu Asp Leu Glu Gly Tyr Leu Val Asn Gly Ser 160 165 170 GCG GGC AGC ATC GCC TCC GGC CGT GTC TCC TAC ACG TTC GGG CTG CGC 14911 Ala Gly Ser Ile Ala Ser Gly Arg Val Ser Tyr Thr Phe Gly Leu Arg 175 180 185 GGC CCC GCG GTC ACC GTC AAT ACG GCC TGT TCG TCG TCA CTG GTG TCG 14959 Gly Pro Ala Val Thr Val Asn Thr Ala Cys Ser Ser Ser Leu Val Ser 190 195 200 CTC CAT CTG GCG GTG CGT GCC CTG CGG AAC GGC GAG TGC GAC ATG GCA 15007 Leu His Leu Ala Val Arg Ala Leu Arg Asn Gly Glu Cys Asp Met Ala 205 210 215 CTG GCC GGC GGG GCG ACG GTG CTG TCC ACC CCC ACC GTG CTC GTG GAC 15055 Leu Ala Gly Gly Ala Thr Val Leu Ser Thr Pro Thr Val Leu Val Asp 220 225 230 235 TTC TCC CGC CAG CGC GGT CTG GCC CCC GAC GGC CGC TGC AAG GCG TTC 15103 Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe 240 245 250 GCC GAC TCC GCC GAC GGC ACC TCC TGG GCC GAG GGC GCC GGA ATG CTG 15151 Ala Asp Ser Ala Asp Gly Thr Ser Trp Ala Glu Gly Ala Gly Met Leu 255 260 265 CTG CTC CAG CGG CTG TCC GAC GCC CGC CGC GAG GGG CGC CCC GTG CTG 15199 Leu Leu Gln Arg Leu Ser Asp Ala Arg Arg Glu Gly Arg Pro Val Leu 270 275 280 GCC GTC ATT CGC GGC TCG GCC GTC AAC CAG GAC GGC GCC AGC AAC GGA 15247 Ala Val Ile Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly 285 290 295 CTG ACC GCC CCC AAC GGG CGG GCG CAG CGG CAG GTC ATC GAG GAC GCG 15295 Leu Thr Ala Pro Asn Gly Arg Ala Gln Arg Gln Val Ile Glu Asp Ala 300 305 310 315 CTG CGC GAC GCC GGG GTC GGC CCC GAC CAG GTG GAC GCG GTC GAG GCG 15343 Leu Arg Asp Ala Gly Val Gly Pro Asp Gln Val Asp Ala Val Glu Ala 320 325 330 CAT GGC ACC GGT ACC GAG CTG GGC GAC CCC ATC GAG GCC GGG GCG CTG 15391 His Gly Thr Gly Thr Glu Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu 335 340 345 CTC GCC ACC TAT GGA ACG GCC CGT ACG GCG GAG CGC CCG CTG TGG CTC 15439 Leu Ala Thr Tyr Gly Thr Ala Arg Thr Ala Glu Arg Pro Leu Trp Leu 350 355 360 GGC TCC CTG AAG TCC AAC ATC GGG CAC ACC CAG GCC GCC GCC GGT GTT 15487 Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val 365 370 375 GCG GGC GTC ATC AAG ATG GTG CTG GCG ATG CGG CAC GGC CGG CTG CCC 15535 Ala Gly Val Ile Lys Met Val Leu Ala Met Arg His Gly Arg Leu Pro 380 385 390 395 CGC ACC CTG CAC GTG GAC CGG CCC ACC ACC CGG GTG GAC TGG GAG AAG 15583 Arg Thr Leu His Val Asp Arg Pro Thr Thr Arg Val Asp Trp Glu Lys 400 405 410 GGC GGG GTG CGG CTC CTC ACG GAG CCG GTG CCA TGG CCG GGG GAA GCG 15631 Gly Gly Val Arg Leu Leu Thr Glu Pro Val Pro Trp Pro Gly Glu Ala 415 420 425 GGG GAG CCG CGT CGC GCG GGC GTG TCC TCC TTC GGC GCG AGC GGC ACG 15679 Gly Glu Pro Arg Arg Ala Gly Val Ser Ser Phe Gly Ala Ser Gly Thr 430 435 440 AAC GCG CAT GTG GTG CTG GAG AGC GTC CCG GCC GGT GAA CCG CCC GCC 15727 Asn Ala His Val Val Leu Glu Ser Val Pro Ala Gly Glu Pro Pro Ala 445 450 455 GCC GGG CGG CCG GAG GAC ACA GGC GGC GCC TGG ACG GTC AGC GGC CGC 15775 Ala Gly Arg Pro Glu Asp Thr Gly Gly Ala Trp Thr Val Ser Gly Arg 460 465 470 475 GGC CCG GCG GCC CTG CGC GCC CAG GCC GCC CGG CTG TAC GAC GCG CTC 15823 Gly Pro Ala Ala Leu Arg Ala Gln Ala Ala Arg Leu Tyr Asp Ala Leu 480 485 490 ACC GGC ACC GGC ACC GGC ACC GGA CAG GGC GCC GGA CAG GGC GCC GGA 15871 Thr Gly Thr Gly Thr Gly Thr Gly Gln Gly Ala Gly Gln Gly Ala Gly 495 500 505 CCC GGC ACC GCC GAG GTG GCC GGC GCG CTG GCC CAC GCC CGT ACC GCG 15919 Pro Gly Thr Ala Glu Val Ala Gly Ala Leu Ala His Ala Arg Thr Ala 510 515 520 TTC CGG CAC CGG GCC GTC GTG CTC GGC GGA AAC CGC GCC GAA CTG CTC 15967 Phe Arg His Arg Ala Val Val Leu Gly Gly Asn Arg Ala Glu Leu Leu 525 530 535 GCG GGG CTG CGC GAG CTG GCG GAG GAG GAG CAT CCC GGA CCC CGC GTG 16015 Ala Gly Leu Arg Glu Leu Ala Glu Glu Glu His Pro Gly Pro Arg Val 540 545 550 555 GTC ACA GGG ACC GCC CCG GCC ACC GAG CGG CGG ACG GCC TTC CTC TTC 16063 Val Thr Gly Thr Ala Pro Ala Thr Glu Arg Arg Thr Ala Phe Leu Phe 560 565 570 TCC GGG CAG GGC AGC CAG CGG GCC GGC TCC GGC CGG GGC CTG TAC CGC 16111 Ser Gly Gln Gly Ser Gln Arg Ala Gly Ser Gly Arg Gly Leu Tyr Arg 575 580 585 CGC CAC CCG GTC TTC GCC CGC GCC CTC GAC GAG GTG TGC GCC GCG CTC 16159 Arg His Pro Val Phe Ala Arg Ala Leu Asp Glu Val Cys Ala Ala Leu 590 595 600 GAA CCG CAT CTT CAC CGC CCC CTG CGT GAC CTG ATG TTC GCC GAG CCC 16207 Glu Pro His Leu His Arg Pro Leu Arg Asp Leu Met Phe Ala Glu Pro 605 610 615 GGC AGC CCG GAA GCG GAG CCG CTC GAC CGC ACC GAG TTC ACC CAG CCC 16255 Gly Ser Pro Glu Ala Glu Pro Leu Asp Arg Thr Glu Phe Thr Gln Pro 620 625 630 635 GCG CTG TTC GCG CTC CAG ACC GCC CTG TTC CGG CTG GCC GAG CAC CAC 16303 Ala Leu Phe Ala Leu Gln Thr Ala Leu Phe Arg Leu Ala Glu His His 640 645 650 GGG CTG CGC GCC GAG GCG CTG TGC GGG CAC AGC GTC GGC GAG ATC GCG 16351 Gly Leu Arg Ala Glu Ala Leu Cys Gly His Ser Val Gly Glu Ile Ala 655 660 665 GCC GCC CAT GCC GCC GGT GTG CTG ACC CTG CCC GAC GCG GCC CGT CTG 16399 Ala Ala His Ala Ala Gly Val Leu Thr Leu Pro Asp Ala Ala Arg Leu 670 675 680 GTG GCC GCC CGG GGA CGG CTG ATG CAG GCC CTG CCG GCC GGC GGT GCC 16447 Val Ala Ala Arg Gly Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala 685 690 695 ATG GCC GCG CTG CGC GCC ACC GCC GAG GAG ATC GCA CCA CTG CTG GAG 16495 Met Ala Ala Leu Arg Ala Thr Ala Glu Glu Ile Ala Pro Leu Leu Glu 700 705 710 715 CGC CGC GCG GGC GAA CTG GCG CTC GCC GCC GTC AAC GGC CCC TCC TCG 16543 Arg Arg Ala Gly Glu Leu Ala Leu Ala Ala Val Asn Gly Pro Ser Ser 720 725 730 GTG GTG GTG TCG GGC GAC GAG GCC GCC GTC CTG GAG CTA CTG GAG CAG 16591 Val Val Val Ser Gly Asp Glu Ala Ala Val Leu Glu Leu Leu Glu Gln 735 740 745 TGG CGG GCC GAG GGC CGC GAG GCC AGG CGG CTC GCC GTC AGC CAT GCC 16639 Trp Arg Ala Glu Gly Arg Glu Ala Arg Arg Leu Ala Val Ser His Ala 750 755 760 TTC CAT TCA CCG CGG ATG GAC GGA ATG TTG ACA CAG TTC GAC CGG GTC 16687 Phe His Ser Pro Arg Met Asp Gly Met Leu Thr Gln Phe Asp Arg Val 765 770 775 GCT CGC ACC CTG ACG TTC GCT CCG CCG ACC ATT CCC CTC GTG TCC ACC 16735 Ala Arg Thr Leu Thr Phe Ala Pro Pro Thr Ile Pro Leu Val Ser Thr 780 785 790 795 CTC ACC GGT ACG CCC GTC ACC GAG GAA ACC CTG TGC ACC GCG GAC CAC 16783 Leu Thr Gly Thr Pro Val Thr Glu Glu Thr Leu Cys Thr Ala Asp His 800 805 810 TGG GTC CGC CAG GCG CGC GAG CCG GTG CGC TTC CTG GAC GCC ATG CGG 16831 Trp Val Arg Gln Ala Arg Glu Pro Val Arg Phe Leu Asp Ala Met Arg 815 820 825 ACC CTG CGC GCC GAC GGG ATC GAC ACC TTC GTG GAA CTC GGC CCC GAC 16879 Thr Leu Arg Ala Asp Gly Ile Asp Thr Phe Val Glu Leu Gly Pro Asp 830 835 840 GGC GTG CTG TCC GCC ATG GCC CGC GAC TGC GCG GAC GAC CGG CCC GAT 16927 Gly Val Leu Ser Ala Met Ala Arg Asp Cys Ala Asp Asp Arg Pro Asp 845 850 855 GGC GAC ACA ACC GGG GCC GGG GAC GGG GAG ACC CCC GAT CCG CTG CTC 16975 Gly Asp Thr Thr Gly Ala Gly Asp Gly Glu Thr Pro Asp Pro Leu Leu 860 865 870 875 ACC CTC CCG CTG CTG CGC CGC TCC GTG CCC GAG ACC GGC GAC GCC GAA 17023 Thr Leu Pro Leu Leu Arg Arg Ser Val Pro Glu Thr Gly Asp Ala Glu 880 885 890 CAC CCC GGC GGC TTC GAA CGG GCC CTG GCC ACC GCC TAC GCA CAC GGC 17071 His Pro Gly Gly Phe Glu Arg Ala Leu Ala Thr Ala Tyr Ala His Gly 895 900 905 GTC CCC CTG CGG CTC GCG CCC GCC CCC GAC GCC GCG TCC CTC GCC GTG 17119 Val Pro Leu Arg Leu Ala Pro Ala Pro Asp Ala Ala Ser Leu Ala Val 910 915 920 GCC GCC GAA CTG CCC ACC TAC GCC TTC CAG CGC ACC CAC TAC TGG CTC 17167 Ala Ala Glu Leu Pro Thr Tyr Ala Phe Gln Arg Thr His Tyr Trp Leu 925 930 935 GAC GCG CCC GCC GCC CCC GCC GCC CTC CCC GCC GGG CTC GAC GAC GCC 17215 Asp Ala Pro Ala Ala Pro Ala Ala Leu Pro Ala Gly Leu Asp Asp Ala 940 945 950 955 GGT CAC CCG CTG CTC TCC GCG GCC CTC GAC CTG CCC GGC GGA CGC GGA 17263 Gly His Pro Leu Leu Ser Ala Ala Leu Asp Leu Pro Gly Gly Arg Gly 960 965 970 ACG GTG TGG ACC GGA GCG CTC TCC GCG GCC ACC CTG CCC TGG GCC GCG 17311 Thr Val Trp Thr Gly Ala Leu Ser Ala Ala Thr Leu Pro Trp Ala Ala 975 980 985 GAC CAC AGC GTG CAC GGC CGC ACC GTC CTG CCG GGC ACC GCC CTG CTC 17359 Asp His Ser Val His Gly Arg Thr Val Leu Pro Gly Thr Ala Leu Leu 990 995 1000 GAC CTG GCG CTC CAC GCC GCC CCG CGC GTC GGC GAG TTG ACC TTC GAG 17407 Asp Leu Ala Leu His Ala Ala Pro Arg Val Gly Glu Leu Thr Phe Glu 1005 1010 1015 GCG CCG CTG GTG CTG CCG GAG GAC GGA GAG GTC CGG CTG CGC GTC GTA 17455 Ala Pro Leu Val Leu Pro Glu Asp Gly Glu Val Arg Leu Arg Val Val 1020 1025 1030 1035 CTC GCT GAA CCG GAC GCG AGC GGA GTA CGC GAA CTG TCT GTC CAC TCC 17503 Leu Ala Glu Pro Asp Ala Ser Gly Val Arg Glu Leu Ser Val His Ser 1040 1045 1050 GCC GGC GAG GAC GGC GGC TGG ACC CGG CAC GCG ACA GCG GTC CTG GAC 17551 Ala Gly Glu Asp Gly Gly Trp Thr Arg His Ala Thr Ala Val Leu Asp 1055 1060 1065 ACC GGC ACC ACC ACC GCC GGG GAG CCC GCC GGC GCA CCG CCC GCC GCA 17599 Thr Gly Thr Thr Thr Ala Gly Glu Pro Ala Gly Ala Pro Pro Ala Ala 1070 1075 1080 TGG CCG CCC GGG GAC GCC GAA CCC CTC GAC CTT GCC GCC GAG TAC GAG 17647 Trp Pro Pro Gly Asp Ala Glu Pro Leu Asp Leu Ala Ala Glu Tyr Glu 1085 1090 1095 CGC TTC GCC GAC GCC GGC ATC GGA TAC GGC CCC GCC TTC CGC GGA CTG 17695 Arg Phe Ala Asp Ala Gly Ile Gly Tyr Gly Pro Ala Phe Arg Gly Leu 1100 1105 1110 1115 CGC TCC GCC TGG CGC GAC GGC GAC GCG ATA CTG GCC GAC GTA CGG CTG 17743 Arg Ser Ala Trp Arg Asp Gly Asp Ala Ile Leu Ala Asp Val Arg Leu 1120 1125 1130 CCC GGC GAA CTG GCC GGC GAA GCC GAC CGG TAC GGC ATC CAC CCG GCC 17791 Pro Gly Glu Leu Ala Gly Glu Ala Asp Arg Tyr Gly Ile His Pro Ala 1135 1140 1145 CTG CTC GAC GCC GCC CTG CAC ACC GCG GCC GCC GCC CTG GGA GGG GCG 17839 Leu Leu Asp Ala Ala Leu His Thr Ala Ala Ala Ala Leu Gly Gly Ala 1150 1155 1160 CAC GGG ATG CTG CCG TTC ACG TGG AAC GGC GTC ACC CTC CAC GCC CGC 17887 His Gly Met Leu Pro Phe Thr Trp Asn Gly Val Thr Leu His Ala Arg 1165 1170 1175 GGA GCG CAC GCC ATC CGG GTG CGG CTG ACC CCG GCC GGC CCC GAC GCG 17935 Gly Ala His Ala Ile Arg Val Arg Leu Thr Pro Ala Gly Pro Asp Ala 1180 1185 1190 1195 GTC GCG GTC ACC GCC GTG GAC CCG GCG GGG CGC CCC GTG TTC ACG GCC 17983 Val Ala Val Thr Ala Val Asp Pro Ala Gly Arg Pro Val Phe Thr Ala 1200 1205 1210 GCC TCG CTC ACC CTG CGA CCG GTC ACG ACC GGG CAG CTG ACC GCG GCC 18031 Ala Ser Leu Thr Leu Arg Pro Val Thr Thr Gly Gln Leu Thr Ala Ala 1215 1220 1225 GAG GCC GCG CGG GCC CCG CTG TAC CGG GTG CGC TGG ACC GGC CTC CCG 18079 Glu Ala Ala Arg Ala Pro Leu Tyr Arg Val Arg Trp Thr Gly Leu Pro 1230 1235 1240 GAC ACC GGA ACC GCC CGG GAC CAC ACC TGG GCG GTG GCC GGC GGC CCG 18127 Asp Thr Gly Thr Ala Arg Asp His Thr Trp Ala Val Ala Gly Gly Pro 1245 1250 1255 GGC GAC CTG TTA CCC GGG GAG ACC CCG CAC CAC CCC GAC CTC GCC TCC 18175 Gly Asp Leu Leu Pro Gly Glu Thr Pro His His Pro Asp Leu Ala Ser 1260 1265 1270 1275 GCG CTC GCC GAC ACC GGC ACC GCC CCC TTC CGC GTA CTG GCG GAT CTG 18223 Ala Leu Ala Asp Thr Gly Thr Ala Pro Phe Arg Val Leu Ala Asp Leu 1280 1285 1290 CGC GGA TAC GGC ACC GCC ACC CCC CGG GAA CTC GCC TCC CAG GCG CTC 18271 Arg Gly Tyr Gly Thr Ala Thr Pro Arg Glu Leu Ala Ser Gln Ala Leu 1295 1300 1305 GCC CTC GTC CAG CAG TGG GCC GAC GCG GCC GAG GCC GCC GAA GGC AGG 18319 Ala Leu Val Gln Gln Trp Ala Asp Ala Ala Glu Ala Ala Glu Gly Arg 1310 1315 1320 CTC GTC CTG GTG ACA CGC CGG GCC GTC GAC ATC GGT GAC GGC GTC ACG 18367 Leu Val Leu Val Thr Arg Arg Ala Val Asp Ile Gly Asp Gly Val Thr 1325 1330 1335 GAC CCG GCG GCG GCG ACC GTG TGG GGA CTG GTC CGG GCG GCA CAG TCC 18415 Asp Pro Ala Ala Ala Thr Val Trp Gly Leu Val Arg Ala Ala Gln Ser 1340 1345 1350 1355 GAG CAC CCC GGG TGC TTC GCG CTC CTC GAC ACC GAC GAC TCC CCC CGC 18463 Glu His Pro Gly Cys Phe Ala Leu Leu Asp Thr Asp Asp Ser Pro Arg 1360 1365 1370 TCC CGG CAA CTC CTG CCA CGC GTC GCG GGC ACC GCC GAG CAG CTC GCA 18511 Ser Arg Gln Leu Leu Pro Arg Val Ala Gly Thr Ala Glu Gln Leu Ala 1375 1380 1385 CTC CGC GAC GGC ACC CTG CTC GCC CCC TCC CTC ACC CGT GCC ACG CTG 18559 Leu Arg Asp Gly Thr Leu Leu Ala Pro Ser Leu Thr Arg Ala Thr Leu 1390 1395 1400 CCC GCC GGC GCC CGG CTG CCC GCA CTC GAC GGC ACC GTC CTG ATC ACT 18607 Pro Ala Gly Ala Arg Leu Pro Ala Leu Asp Gly Thr Val Leu Ile Thr 1405 1410 1415 GGG GGC ACC GGC AGC CTC GGC GCG GAG GCG GCC CGC CAT CTG GTC ACC 18655 Gly Gly Thr Gly Ser Leu Gly Ala Glu Ala Ala Arg His Leu Val Thr 1420 1425 1430 1435 CGG CAC GGT GCC CGG CGC CTG CTC CTG ACC AGC CGA AGC GGC CCG CAG 18703 Arg His Gly Ala Arg Arg Leu Leu Leu Thr Ser Arg Ser Gly Pro Gln 1440 1445 1450 GCC CCC GGC GCG GCC GAA CTC GTC GCC GAA CTG GCC GCC TTG GGC GCC 18751 Ala Pro Gly Ala Ala Glu Leu Val Ala Glu Leu Ala Ala Leu Gly Ala 1455 1460 1465 CAC GCG GAC GTG GCC GCC TGC GAC GTC GCC GAC CGC GCC GCC CTG CGG 18799 His Ala Asp Val Ala Ala Cys Asp Val Ala Asp Arg Ala Ala Leu Arg 1470 1475 1480 GCC CTG CTC GAC CGC GTA CCC GCC GGC CAC CCG CTG ACC GCG GTC CTG 18847 Ala Leu Leu Asp Arg Val Pro Ala Gly His Pro Leu Thr Ala Val Leu 1485 1490 1495 CAC ACG GCG GGC GTC CTG GAC GAC GGC GTC CTC ACC GCC CAG ACA CCG 18895 His Thr Ala Gly Val Leu Asp Asp Gly Val Leu Thr Ala Gln Thr Pro 1500 1505 1510 1515 CAG CGG CTC GCG GCC GTC CTC CGC CCG AAG GCC GAC GCC GTA CGC AAT 18943 Gln Arg Leu Ala Ala Val Leu Arg Pro Lys Ala Asp Ala Val Arg Asn 1520 1525 1530 CTG CAC GAA CTC ACC CAG GGG CAC GCC CTG TCG GCG TTC ATC CTC TAC 18991 Leu His Glu Leu Thr Gln Gly His Ala Leu Ser Ala Phe Ile Leu Tyr 1535 1540 1545 TCG TCG GCC GCC GGA GTG CTC GGC AGC GCG GGC CAG AGC GGC TAC GCC 19039 Ser Ser Ala Ala Gly Val Leu Gly Ser Ala Gly Gln Ser Gly Tyr Ala 1550 1555 1560 GCC GCC AAC GCC TAC CTG GAC TCC TTC GCC GTC TGG CGG CGG AGC CGG 19087 Ala Ala Asn Ala Tyr Leu Asp Ser Phe Ala Val Trp Arg Arg Ser Arg 1565 1570 1575 GGA CTG CCC GCC GTA TCG CTC GGC TGG GGC CCG TGG GAC GGC GGC GGC 19135 Gly Leu Pro Ala Val Ser Leu Gly Trp Gly Pro Trp Asp Gly Gly Gly 1580 1585 1590 1595 ATG GCG AGC GGA CTC GGC GGA ACC GAC ACG GCC CGG CTG CGG CGC AGC 19183 Met Ala Ser Gly Leu Gly Gly Thr Asp Thr Ala Arg Leu Arg Arg Ser 1600 1605 1610 GGC ATC GCA CCC CTC AGC CGC GCC GAG GGC CTG GCC GCG CTC GAC GCG 19231 Gly Ile Ala Pro Leu Ser Arg Ala Glu Gly Leu Ala Ala Leu Asp Ala 1615 1620 1625 GCG CTC GCG GCC GGC GGC GAC GAC ACC GCG CCG GCC CAC CTG CTG CCG 19279 Ala Leu Ala Ala Gly Gly Asp Asp Thr Ala Pro Ala His Leu Leu Pro 1630 1635 1640 ATC CGC GTC GAC GCG GTG ACC CTG CGC GGC GCC GAC ACC GTC CCC GCC 19327 Ile Arg Val Asp Ala Val Thr Leu Arg Gly Ala Asp Thr Val Pro Ala 1645 1650 1655 GTG CTG CGC GAC CTG GCG GGA ACC GCG CCA AGC GCC GCC GAA CGG CCC 19375 Val Leu Arg Asp Leu Ala Gly Thr Ala Pro Ser Ala Ala Glu Arg Pro 1660 1665 1670 1675 CCC GGG ACA CCG GAG GAC ACG AAC GCG CCC CTG GCG GAC GTC ACC CAA 19423 Pro Gly Thr Pro Glu Asp Thr Asn Ala Pro Leu Ala Asp Val Thr Gln 1680 1685 1690 CTG CAC GGC CGG GAA CGG AAG GAG GCA CTG ACC GGC TTC GTA CGC GCC 19471 Leu His Gly Arg Glu Arg Lys Glu Ala Leu Thr Gly Phe Val Arg Ala 1695 1700 1705 CAG GTG GCC GCG GTG CTC GGC CAC CCC ACG TCC GAC ACG ATC GAC GTC 19519 Gln Val Ala Ala Val Leu Gly His Pro Thr Ser Asp Thr Ile Asp Val 1710 1715 1720 CGC CGG AGC TTC AAG GAA GCG GGC TTC GAC TCC CTC ACC GCC GTC GAA 19567 Arg Arg Ser Phe Lys Glu Ala Gly Phe Asp Ser Leu Thr Ala Val Glu 1725 1730 1735 CTG CGC AAC CGG CTG CGC GCC GCC ACC GGG CTG AAG CTG CCC GCC ACG 19615 Leu Arg Asn Arg Leu Arg Ala Ala Thr Gly Leu Lys Leu Pro Ala Thr 1740 1745 1750 1755 CTG GTG TTC GAC CAC CCG ACC CCC CTC GCG CTC GCC GGC TTC CTC CAC 19663 Leu Val Phe Asp His Pro Thr Pro Leu Ala Leu Ala Gly Phe Leu His 1760 1765 1770 CGC GAA CTC CCC GGC GCC GAA GCC TCC CTG ATG AGC GCG ATC GAC ACT 19711 Arg Glu Leu Pro Gly Ala Glu Ala Ser Leu Met Ser Ala Ile Asp Thr 1775 1780 1785 CTC CGG CAC CGG CTG CGC GAC GCC CTG GCC GAC GAC GCC GCA GAC GAC 19759 Leu Arg His Arg Leu Arg Asp Ala Leu Ala Asp Asp Ala Ala Asp Asp 1790 1795 1800 GCC CTG CGC GAC CAG ATC ACC CGA CGA CTC GAG ACC CTG CTG GCC GGC 19807 Ala Leu Arg Asp Gln Ile Thr Arg Arg Leu Glu Thr Leu Leu Ala Gly 1805 1810 1815 ATA GCC CGG ACC GAG GAG CCC GCG CCC GCC ACC GCC GCC GCC GAC GAC 19855 Ile Ala Arg Thr Glu Glu Pro Ala Pro Ala Thr Ala Ala Ala Asp Asp 1820 1825 1830 1835 GGG AGC GGA GCC GGT GAT GTC GCG GAA CGA CTG AGC ACC GCG TCG GAC 19903 Gly Ser Gly Ala Gly Asp Val Ala Glu Arg Leu Ser Thr Ala Ser Asp 1840 1845 1850 GAC GAA CTG TTC GAA CTG CTC GAC AGC GGT TTC ACA CCC TGA CCGGCCGGCG 19955 Asp Glu Leu Phe Glu Leu Leu Asp Ser Gly Phe Thr Pro * 1855 1860 1865 GACCGGCACC ACGACATCGA GGCGACCGCA CCGAACACCC CCAGGGGGAA AGCT 20009 GTG TCC ACC GAG AAC TCC ACC AAC GTC CCG GCG AGC GAG 20048 Met Ser Thr Glu Asn Ser Thr Asn Val Pro Ala Ser Glu 1 5 10 GAC AAG CTC CGC GCC TAT CTG CGT CGC GCG ATG GCC GAC CTC CAC GAG 20096 Asp Lys Leu Arg Ala Tyr Leu Arg Arg Ala Met Ala Asp Leu His Glu 15 20 25 TCC CGC GAA CGG CTC CGC GCC ACG GAA GCG CGC GCC CAG GAG CCG ATC 20144 Ser Arg Glu Arg Leu Arg Ala Thr Glu Ala Arg Ala Gln Glu Pro Ile 30 35 40 45 GCG GTG GTG GGT ATG GGG TGC CGG TTC CCC GGT GGG GTG GGT TCG CCG 20192 Ala Val Val Gly Met Gly Cys Arg Phe Pro Gly Gly Val Gly Ser Pro 50 55 60 GAG GCG TTG TGG CGG TTG GTG GTG GAG GGG GTG GAC GCG GTT TCC CCG 20240 Glu Ala Leu Trp Arg Leu Val Val Glu Gly Val Asp Ala Val Ser Pro 65 70 75 TTT CCC GGT GAT CGT GGC TGG GAT GTG GAG GGG TTG TAC GAC CCG GAG 20288 Phe Pro Gly Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr Asp Pro Glu 80 85 90 CCG GGT GTG GCG GGG AAG TCG TAT GTG CGG GAG GGG GGT TTT CTG CAT 20336 Pro Gly Val Ala Gly Lys Ser Tyr Val Arg Glu Gly Gly Phe Leu His 95 100 105 GAT GCG GCG GAG TTC GAT GCG GAG TTC TTC GGG ATT TCG CCG CGT GAG 20384 Asp Ala Ala Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu 110 115 120 125 GCG GTG GCG ATG GAT CCG CAG CAG CGG CTG TTG CTG GAG ACC TCC TGG 20432 Ala Val Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp 130 135 140 GAG GCG ATC GAG CGG GCG GGT ATC GAC CCG CAT TCG CTG CAC GGC AGC 20480 Glu Ala Ile Glu Arg Ala Gly Ile Asp Pro His Ser Leu His Gly Ser 145 150 155 CGC ACC GGC GTC TAC GCC GGC GTG ATG TAC CAC GAC TAT GGC ACG GGA 20528 Arg Thr Gly Val Tyr Ala Gly Val Met Tyr His Asp Tyr Gly Thr Gly 160 165 170 CAG ACC TCC GCG ACC GAC ACG AGC GGT TAT TCC GGC ACC GGT ACG TCG 20576 Gln Thr Ser Ala Thr Asp Thr Ser Gly Tyr Ser Gly Thr Gly Thr Ser 175 180 185 GGG AGT GTG GTG TCG GGG CGT GTG GCC TAC ACG CTG GGG CTG GAG GGT 20624 Gly Ser Val Val Ser Gly Arg Val Ala Tyr Thr Leu Gly Leu Glu Gly 190 195 200 205 CCG GCC GTG ACC GTG GAT ACG GCG TGT TCG TCG TCG TTG GTG GCG TTG 20672 Pro Ala Val Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 210 215 220 CAT CTG GCG GTG CAG GCG TTG CGG GGT GGC GAG TGT GAC ATG GCG TTG 20720 His Leu Ala Val Gln Ala Leu Arg Gly Gly Glu Cys Asp Met Ala Leu 225 230 235 GCC GGT GGT GTG ACG GTG ATG GCC GGG CCG GGG ATG TTC GTG GAG TTT 20768 Ala Gly Gly Val Thr Val Met Ala Gly Pro Gly Met Phe Val Glu Phe 240 245 250 TCG CGG CAG CGG GGG TTG GCG GCC GAT GGG CGG TGC AAG GCG TTC GCG 20816 Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala 255 260 265 GAT GGG GCG GAT GGG ACC GCT TGG GCC GAG GGT GCG GGG GTG GTG CTG 20864 Asp Gly Ala Asp Gly Thr Ala Trp Ala Glu Gly Ala Gly Val Val Leu 270 275 280 285 GTG GAG CGG TTG TCG GAT GCC CGG CGG TTG GGG CAT CCG GTG TTG GCG 20912 Val Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Pro Val Leu Ala 290 295 300 GTG GTG TGT GGG TCG GCG GTG AAT CAG GAC GGT GCG TCG AAT GGT TTG 20960 Val Val Cys Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu 305 310 315 ACG GCG CCG AGT GGT CCG TCG CAG GAG CGG GTG ATT CGT CAG GCG TTG 21008 Thr Ala Pro Ser Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu 320 325 330 GCG AAT GCG CGG TTG ACG GTG GCG GAT GTG GAT GTG GTG GAG GCG CAT 21056 Ala Asn Ala Arg Leu Thr Val Ala Asp Val Asp Val Val Glu Ala His 335 340 345 GGG ACG GGG ACG CGG CTG GGT GAT CCG ATC GAG GCG CAG GCG TTG CTG 21104 Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu 350 355 360 365 GGG ACG TAT GGG CGG GAT CGT GAT GGT GGG CGT CCG GTG TGG TTG GGG 21152 Gly Thr Tyr Gly Arg Asp Arg Asp Gly Gly Arg Pro Val Trp Leu Gly 370 375 380 TCG TTG AAG TCG AAT ATT GGT CAT GCT CAG GCG GCT GCG GGG GTG GCT 21200 Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ala 385 390 395 GGT GTG ATC AAG ATG GTG TTG GCG ATG CGG TAT GGG TGG TTG CCG CGG 21248 Gly Val Ile Lys Met Val Leu Ala Met Arg Tyr Gly Trp Leu Pro Arg 400 405 410 ACG TTG CAT GTG GAT GAG CCG AGC CGG CAT GTG GAC TGG TCG GCT GGT 21296 Thr Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly 415 420 425 GGT GTG TGG TTG CTG ACC GAG GCG CGG GAG TGG CCG GGG GTG GAC CGG 21344 Gly Val Trp Leu Leu Thr Glu Ala Arg Glu Trp Pro Gly Val Asp Arg 430 435 440 445 CCG CGT CGG GCG GCG GTC TCC GCC TTT GGT GTC AGT GGT ACC AAC GCC 21392 Pro Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala 450 455 460 CAT CTG ATC CTC GAA GCC CCC GAC ACC GCC GAG GCG GAG AGC GCC ACG 21440 His Leu Ile Leu Glu Ala Pro Asp Thr Ala Glu Ala Glu Ser Ala Thr 465 470 475 ACC CCG GTC CGC TCT GAG GTG TCG GAG TCT GCT GCG GTC TTC GAT GCC 21488 Thr Pro Val Arg Ser Glu Val Ser Glu Ser Ala Ala Val Phe Asp Ala 480 485 490 CGC AGT GGT GTG GTG CCG GTG GTG GTT TCG GGG CGT TCG CGG GTG GTG 21536 Arg Ser Gly Val Val Pro Val Val Val Ser Gly Arg Ser Arg Val Val 495 500 505 GTG CGG GAG GCT GCG GGC CGG TTG GCG GAG GTG GTG GAG GCC GGT GGT 21584 Val Arg Glu Ala Ala Gly Arg Leu Ala Glu Val Val Glu Ala Gly Gly 510 515 520 525 GTG GGG CTG GCG GAT GTG GCG GTG ACG ATG GCG GGC CGG TCG CGG TTT 21632 Val Gly Leu Ala Asp Val Ala Val Thr Met Ala Gly Arg Ser Arg Phe 530 535 540 GGG TAT CGG GCG GTT GTG CTG GCT CGG GGT GAG GCT GAG CTT GCC GGG 21680 Gly Tyr Arg Ala Val Val Leu Ala Arg Gly Glu Ala Glu Leu Ala Gly 545 550 555 CGT TTG CGG GCG TTG GCG GGG GGT GAT CCG GAC GCG GGT GTG GTC ACG 21728 Arg Leu Arg Ala Leu Ala Gly Gly Asp Pro Asp Ala Gly Val Val Thr 560 565 570 GGT GCG GTG GTG GAC CCG GAG ACG GGG TCC GGT GGT GGG GGG GTG GTG 21776 Gly Ala Val Val Asp Pro Glu Thr Gly Ser Gly Gly Gly Gly Val Val 575 580 585 TTG GTT TTC CCT GGT CAG GGG ACG CAG TGG GTG GGG ATG GGT GCG GGG 21824 Leu Val Phe Pro Gly Gln Gly Thr Gln Trp Val Gly Met Gly Ala Gly 590 595 600 605 CTG CTG GGG TCT TCG GAG GTG TTT GCG GCG TCG ATG CGG GAG TGT GCG 21872 Leu Leu Gly Ser Ser Glu Val Phe Ala Ala Ser Met Arg Glu Cys Ala 610 615 620 CGG GCG CTG AGT GTT CAT GTG GGG TGG GAT TTG CTG GAG GTG GTG TCG 21920 Arg Ala Leu Ser Val His Val Gly Trp Asp Leu Leu Glu Val Val Ser 625 630 635 GGC GGG GCC GGG TTG GAG CGG GTG GAT GTG GTG CAG CCG GTG ACG TGG 21968 Gly Gly Ala Gly Leu Glu Arg Val Asp Val Val Gln Pro Val Thr Trp 640 645 650 GCG GTG ATG GTG TCG CTG GCC CGG TAC TGG CAG GCG ATG GGT GTG GAC 22016 Ala Val Met Val Ser Leu Ala Arg Tyr Trp Gln Ala Met Gly Val Asp 655 660 665 GTG GCT GCG GTG GTG GGT CAT TCC CAG GGG GAG ATC GCT GCT GCC ACG 22064 Val Ala Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Thr 670 675 680 685 GTG GCG GGG GCG TTG TCG CTG GAG GAT GCG GCG GCT GTG GTC GCT CTG 22112 Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Ala Val Val Ala Leu 690 695 700 CGG GCG GGG TTG ATT GGC CGG TAT CTG GCG GGT CGT GGT GCG ATG GCG 22160 Arg Ala Gly Leu Ile Gly Arg Tyr Leu Ala Gly Arg Gly Ala Met Ala 705 710 715 GCT GTT CCG CTG CCT GCC GGC GAG GTC GAG GCC GGG CTG GCG AAG TGG 22208 Ala Val Pro Leu Pro Ala Gly Glu Val Glu Ala Gly Leu Ala Lys Trp 720 725 730 CCG GGT GTG GAG GTC GCG GCG GTC AAC GGT CCG GCG TCT ACG GTG GTT 22256 Pro Gly Val Glu Val Ala Ala Val Asn Gly Pro Ala Ser Thr Val Val 735 740 745 TCC GGG GAT CGG CGG GCG GTG GCC GGT TAT GTG GCC GTC TGT CAG GCG 22304 Ser Gly Asp Arg Arg Ala Val Ala Gly Tyr Val Ala Val Cys Gln Ala 750 755 760 765 GAG GGT GTG CAG GCT CGG TTG ATA CCG GTG GAC TAC GCC TCT CAC TCC 22352 Glu Gly Val Gln Ala Arg Leu Ile Pro Val Asp Tyr Ala Ser His Ser 770 775 780 CGC CAT GTG GAG GAC CTG AAG GGC GAG TTG GAG CGG GTG CTG TCC GGT 22400 Arg His Val Glu Asp Leu Lys Gly Glu Leu Glu Arg Val Leu Ser Gly 785 790 795 ATC CGC CCG CGC AGT CCG CGG GTG CCG GTG TGT TCC ACC GTC GCC GGA 22448 Ile Arg Pro Arg Ser Pro Arg Val Pro Val Cys Ser Thr Val Ala Gly 800 805 810 GAG CAG CCG GGC GAG CCG GTT TTC GAT GCG GGG TAT TGG TTC CGT AAT 22496 Glu Gln Pro Gly Glu Pro Val Phe Asp Ala Gly Tyr Trp Phe Arg Asn 815 820 825 CTG CGG AAC CGG GTT GAG TTC TCC GCG GTG GTC GGT GGT TTG TTG GAG 22544 Leu Arg Asn Arg Val Glu Phe Ser Ala Val Val Gly Gly Leu Leu Glu 830 835 840 845 GAG GGC CAC CGT CGG TTC ATC GAG GTC AGT GCC CAC CCG GTA CTC GTT 22592 Glu Gly His Arg Arg Phe Ile Glu Val Ser Ala His Pro Val Leu Val 850 855 860 CAT GCC ATT GAG CAG ACG GCC GAG GCC GCG GAC CGG AGT GTC CAT GCC 22640 His Ala Ile Glu Gln Thr Ala Glu Ala Ala Asp Arg Ser Val His Ala 865 870 875 ACC GGG ACC CTG CGC CGC CAG GAC GAC AGC CCG CAC CGC CTG CTG ACC 22688 Thr Gly Thr Leu Arg Arg Gln Asp Asp Ser Pro His Arg Leu Leu Thr 880 885 890 TCC ACC GCC GAG GCC TGG GCC CAC GGC GCC ACC CTC ACC TGG GAC CCC 22736 Ser Thr Ala Glu Ala Trp Ala His Gly Ala Thr Leu Thr Trp Asp Pro 895 900 905 GCC CTG CCC CCA GGC CAC CTC ACC ACC CTC CCC ACC TAC CCC TTC AAC 22784 Ala Leu Pro Pro Gly His Leu Thr Thr Leu Pro Thr Tyr Pro Phe Asn 910 915 920 925 CAC CAC CAC TAC TGG CTC GAC ACC ACC CCC ACC ACC CCC GCG ACG ACC 22832 His His His Tyr Trp Leu Asp Thr Thr Pro Thr Thr Pro Ala Thr Thr 930 935 940 ACC CAG AGC CCC ACC GAT GCC CAG AAC CCC GCC GAC GCC CTT CCC TAC 22880 Thr Gln Ser Pro Thr Asp Ala Gln Asn Pro Ala Asp Ala Leu Pro Tyr 945 950 955 AAG GTG AGT TGG AAG CGG TTG CGG GAC CAG GAC AGC TTG ACC GCG CGC 22928 Lys Val Ser Trp Lys Arg Leu Arg Asp Gln Asp Ser Leu Thr Ala Arg 960 965 970 CTC GAC GGC CGA TGG CTG CTG GTG GTA CCG GAG GCG TCG GCG GAC CCG 22976 Leu Asp Gly Arg Trp Leu Leu Val Val Pro Glu Ala Ser Ala Asp Pro 975 980 985 TCG GTT GCT GAG GGC GTC GCG CGC GAG CTG ACC GCG CGG GGC GCG ACC 23024 Ser Val Ala Glu Gly Val Ala Arg Glu Leu Thr Ala Arg Gly Ala Thr 990 995 1000 1005 GTG GAG TCG CTG ACG GTC GAG CCG GGC GCC GAC CGT TCG CGG CTG CGC 23072 Val Glu Ser Leu Thr Val Glu Pro Gly Ala Asp Arg Ser Arg Leu Arg 1010 1015 1020 GGG CTG CTG GTC GAC GCC ACG GAA CGG GAC GAA GCC GGG CCG CTG CGC 23120 Gly Leu Leu Val Asp Ala Thr Glu Arg Asp Glu Ala Gly Pro Leu Arg 1025 1030 1035 GGG ATC GTC TCG CTG CTG GCG TTG GCC GGG GAC CAC GCC GGG GCC GAC 23168 Gly Ile Val Ser Leu Leu Ala Leu Ala Gly Asp His Ala Gly Ala Asp 1040 1045 1050 GGG GCA CGC CCG GTG GTT CCG GCC GGC CTG GCA GCG TCA CTG GCG CTG 23216 Gly Ala Arg Pro Val Val Pro Ala Gly Leu Ala Ala Ser Leu Ala Leu 1055 1060 1065 ATC CAG GCC GCG GGC GAC GCG GGC ACG GAG GCC GGG CTG TGG GCG GTG 23264 Ile Gln Ala Ala Gly Asp Ala Gly Thr Glu Ala Gly Leu Trp Ala Val 1070 1075 1080 1085 ACC CGC GGC GCC GTC GCG GCC GTG CCC GGT GAC GTA CCG GCG CCG TCG 23312 Thr Arg Gly Ala Val Ala Ala Val Pro Gly Asp Val Pro Ala Pro Ser 1090 1095 1100 CAG GCG CTG CTC TGG GGA TTC GGC CGG GTG GCC GGG ATC GAG CTG CCG 23360 Gln Ala Leu Leu Trp Gly Phe Gly Arg Val Ala Gly Ile Glu Leu Pro 1105 1110 1115 CAC TGC TGG GGC GGC CTG CTC GAC CTG CCG ACC GGG CCC GGC GAC TCC 23408 His Cys Trp Gly Gly Leu Leu Asp Leu Pro Thr Gly Pro Gly Asp Ser 1120 1125 1130 GGG TTC CGG CAA CTG GCC GCG ACC CTG GCG GGC CGT CCC GCG GAG GAC 23456 Gly Phe Arg Gln Leu Ala Ala Thr Leu Ala Gly Arg Pro Ala Glu Asp 1135 1140 1145 CAG GTG GCG CTG CGG GCT TCG GGC GCG TAC GGC CGC AGG CTG GTC CGG 23504 Gln Val Ala Leu Arg Ala Ser Gly Ala Tyr Gly Arg Arg Leu Val Arg 1150 1155 1160 1165 GCC TCC GCG GCG GGC GGC GCG GAC GGC TGG CGG CCG CGG GGA ACG GTG 23552 Ala Ser Ala Ala Gly Gly Ala Asp Gly Trp Arg Pro Arg Gly Thr Val 1170 1175 1180 CTG GTG GTG GGC GAC ACC GCG GAG GTC GCC GGA CCG CTG GTG CGC TGG 23600 Leu Val Val Gly Asp Thr Ala Glu Val Ala Gly Pro Leu Val Arg Trp 1185 1190 1195 CTG CTC GGC AAC GGC GCA CGG CGG GTG ACC CTG TCC GGA CTC TCC GGC 23648 Leu Leu Gly Asn Gly Ala Arg Arg Val Thr Leu Ser Gly Leu Ser Gly 1200 1205 1210 CCG CTG CCG GAG GAA CTC GCC GAT GTG GCG GCA CGG GTG ACC GTG GCG 23696 Pro Leu Pro Glu Glu Leu Ala Asp Val Ala Ala Arg Val Thr Val Ala 1215 1220 1225 CCC TGT GAT CCG GCC GAT CGC CCC GCC CTG CGG ACG CTG CTC GCC GAA 23744 Pro Cys Asp Pro Ala Asp Arg Pro Ala Leu Arg Thr Leu Leu Ala Glu 1230 1235 1240 1245 CAG GCG CCG ACC GCC GTG CTC GTG GCG CCC CCG GCC GTC CCG CCC ACG 23792G ln Ala Pro Thr Ala Val Leu Val Ala Pro Pro Ala Val Pro Pro Thr 1250 1255 1260 CCG CTC GCG GAG ATG ACC GCC GAG GCG TTA GCC ATC GCG CTG TCC GCG 23840 Pro Leu Ala Glu Met Thr Ala Glu Ala Leu Ala Ile Ala Leu Ser Ala 1265 1270 1275 AAG ACC GGT CTG GTC GAC CGT CTG GAC TCG CTG CTC GAC GAG CCG GAC 23888 Lys Thr Gly Leu Val Asp Arg Leu Asp Ser Leu Leu Asp Glu Pro Asp 1280 1285 1290 CCC CTG CTC GAG GAC GGG GAA CTC GAC GCG TTC GTC GTC TTC TCC TCC 23936 Pro Leu Leu Glu Asp Gly Glu Leu Asp Ala Phe Val Val Phe Ser Ser 1295 1300 1305 GTG GCA GGG GTG TGG GGC GGC GCG GGA CAG GGT GGT TAC GCG GCC GGT 23984 Val Ala Gly Val Trp Gly Gly Ala Gly Gln Gly Gly Tyr Ala Ala Gly 1310 1315 1320 1325 ACC GCG TAC CTC GAC GCG CTC GCC GAA TGC CGG CGG GCC GGG GGG CTG 24032 Thr Ala Tyr Leu Asp Ala Leu Ala Glu Cys Arg Arg Ala Gly Gly Leu 1330 1335 1340 CCG GTC ACC TCG GTG GCG TGG ACG CCG TGG CTC GGT ACG CCG GCG GCG 24080 Pro Val Thr Ser Val Ala Trp Thr Pro Trp Leu Gly Thr Pro Ala Ala 1345 1350 1355 GAC TCC CTG GGC GAG CAG ATG AGC CGA GCT GGC ATC ACC CCC CTG GAT 24128 Asp Ser Leu Gly Glu Gln Met Ser Arg Ala Gly Ile Thr Pro Leu Asp 1360 1365 1370 CCG GCG GCC TCG CTG GAT GCG CTC GCC CGT GCG GTG GGC CGG CGC GCG 24176 Pro Ala Ala Ser Leu Asp Ala Leu Ala Arg Ala Val Gly Arg Arg Ala 1375 1380 1385 GGC TGT GTG ACG GTC GCC GAC ATC GAC TGG GAG CGG TTC GCC TCC GCG 24224 Gly Cys Val Thr Val Ala Asp Ile Asp Trp Glu Arg Phe Ala Ser Ala 1390 1395 1400 1405 TAC ACG GCC ACC CGT CCC ACG CCG ATG TTC GAC GAG GTG CCC GAG GTG 24272 Tyr Thr Ala Thr Arg Pro Thr Pro Met Phe Asp Glu Val Pro Glu Val 1410 1415 1420 CGG CGG ATA CAG GCC GCG TGG GCG GAA GCG GAG GCC GAC GCC GCG CGC 24320 Arg Arg Ile Gln Ala Ala Trp Ala Glu Ala Glu Ala Asp Ala Ala Arg 1425 1430 1435 AGC GGT GCC GGC GGC GAC TCG CAG CTG CTG CGC TCC CTC CGG GGC CGG 24368 Ser Gly Ala Gly Gly Asp Ser Gln Leu Leu Arg Ser Leu Arg Gly Arg 1440 1445 1450 CCC GAG GAG GCC CAA CTG GCG GAG CTG CTG CGG CTG GTG CGC ACC CAT 24416 Pro Glu Glu Ala Gln Leu Ala Glu Leu Leu Arg Leu Val Arg Thr His 1455 1460 1465 GCC GCC GCG GTG CTC GGC CTG GGC TCG CCC GGC GCG GTG GAG GCG CGG 24464 Ala Ala Ala Val Leu Gly Leu Gly Ser Pro Gly Ala Val Glu Ala Arg 1470 1475 1480 1485 CGT TCG TTC AAG GAC CTG GGC TTC AAC TCG GTG ACG GCG GTG GAG CTG 24512 Arg Ser Phe Lys Asp Leu Gly Phe Asn Ser Val Thr Ala Val Glu Leu 1490 1495 1500 CGG AAC CGG CTG AAG GAG GCG ACG GGA CTC CGG CTG GAG GTG TCC CTG 24560 Arg Asn Arg Leu Lys Glu Ala Thr Gly Leu Arg Leu Glu Val Ser Leu 1505 1510 1515 GTC TTC GAC CAC CCG GAC CCG GCC TCC CTC GCC CGG CAT CTG CTG GAT 24608 Val Phe Asp His Pro Asp Pro Ala Ser Leu Ala Arg His Leu Leu Asp 1520 1525 1530 CTC GCC CTC GGC CAG GAG CCG GAG GAG ACG CCG CGG GCG TTC GCG CTC 24656 Leu Ala Leu Gly Gln Glu Pro Glu Glu Thr Pro Arg Ala Phe Ala Leu 1535 1540 1545 GAA CCC GCG CCG AAC GGG GAG CCG ATC GCG ATC GTG TCC ATG GCC TGC 24704 Glu Pro Ala Pro Asn Gly Glu Pro Ile Ala Ile Val Ser Met Ala Cys 1550 1555 1560 1565 CGT ATG CCG GGG GGT GTC AGC ACG CCC GAG GAG CTG TGG CGG CTG CTG 24752 Arg Met Pro Gly Gly Val Ser Thr Pro Glu Glu Leu Trp Arg Leu Leu 1570 1575 1580 CGG GAC GGC AAG GAC GCG ATC GGG CCG TTC CCC GCC AAC CGG GGC TGG 24800 Arg Asp Gly Lys Asp Ala Ile Gly Pro Phe Pro Ala Asn Arg Gly Trp 1585 1590 1595 GAC CTG GAG AAC CTC TAC GAC CCC GAC CCG GAC GCC GAC GGC CGC ACC 24848 Asp Leu Glu Asn Leu Tyr Asp Pro Asp Pro Asp Ala Asp Gly Arg Thr 1600 1605 1610 TAT GTG CGC GAG GGC GGA TTC CTC CAC GAG GCA CCG GAC TTC GAC CCC 24896 Tyr Val Arg Glu Gly Gly Phe Leu His Glu Ala Pro Asp Phe Asp Pro 1615 1620 1625 TCG TTC TTC GGC ATC TCG CCG CGC GAG GCG CTG GCG ATG GAC CCG CAG 24944 Ser Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln 1630 1635 1640 1645 CAG CGG CTG CTG CTG GAG ACT TCC TGG GAG GCC TTG GAG CGC GCC GGC 24992 Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu Arg Ala Gly 1650 1655 1660 ATC GAC CCG GCG AGG CTG CGC GGC AGC CGT ACC GGC GTC TTC GTC GGG 25040 Ile Asp Pro Ala Arg Leu Arg Gly Ser Arg Thr Gly Val Phe Val Gly 1665 1670 1675 ACG AAC GGC CAG CAC TAC ATG CCG CTG CTC CAG AAC GGC GGG GAC AGC 25088 Thr Asn Gly Gln His Tyr Met Pro Leu Leu Gln Asn Gly Gly Asp Ser 1680 1685 1690 TTC GAC GGC TAT CTG GGC ACC GGC AAC TCG GCG AGT GTG ATG TCG GGC 25136 Phe Asp Gly Tyr Leu Gly Thr Gly Asn Ser Ala Ser Val Met Ser Gly 1695 1700 1705 CGG CTG TCG TAC GTG TTC GGC CTC GAA GGC CCC GCC GTG ACC GTG GAC 25184 Arg Leu Ser Tyr Val Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp 1710 1715 1720 1725 ACC GCC TGC TCG GCG TCC CTG GTG GCG CTG CAC CTG GCG GTG CAG GCG 25232 Thr Ala Cys Ser Ala Ser Leu Val Ala Leu His Leu Ala Val Gln Ala 1730 1735 1740 ATG CGG CGC GGC GAG TGC GAC ATG GCG CTG GTC GGC GGC GCG ACG GTG 25280 Met Arg Arg Gly Glu Cys Asp Met Ala Leu Val Gly Gly Ala Thr Val 1745 1750 1755 ATG TCG ACG CCC GAG ATG CTG GTG GAG TTC TCC CGG CAG CGG GTG ATC 25328 Met Ser Thr Pro Glu Met Leu Val Glu Phe Ser Arg Gln Arg Val Ile 1760 1765 1770 TCC GCC AAC GGC CGG TCG AGG GCC TTC GCC GCC GGT GCC GAC GGT GTG 25376 Ser Ala Asn Gly Arg Ser Arg Ala Phe Ala Ala Gly Ala Asp Gly Val 1775 1780 1785 GCG CTC GGC GAG GGC GTG GGC GTC CTG CTG GTG GAG CGG CTG TCG GAC 25424 Ala Leu Gly Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp 1790 1795 1800 1805 GCC GAG CGC AAC GGC CAT CCG GTG CTG GCG GTG GTC CGC GGC TCG GCG 25472 Ala Glu Arg Asn Gly His Pro Val Leu Ala Val Val Arg Gly Ser Ala 1810 1815 1820 GTC AAC CAG GAC GGC GCC TCC AAC GGG CTG ACG GCG CCC AAC GGG CCC 25520 Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro 1825 1830 1835 TCC CAG CAG CGG GTG ATC CGG CAG GCG CTG GCG GAC GCC GGG CTG CGG 25568 Ser Gln Gln Arg Val Ile Arg Gln Ala Leu Ala Asp Ala Gly Leu Arg 1840 1845 1850 CCC GAG GAC ATC GAC GCC GTC GAG GCG CAC GGC ACC GGC ACC GAG CTG 25616 Pro Glu Asp Ile Asp Ala Val Glu Ala His Gly Thr Gly Thr Glu Leu 1855 1860 1865 GGC GAC CCC ATC GAG GCC GAG GCG CTG CTC GCC ACC TAT GGA AGG ACC 25664 Gly Asp Pro Ile Glu Ala Glu Ala Leu Leu Ala Thr Tyr Gly Arg Thr 1870 1875 1880 1885 CGT ACG GCG GAC CGC CCG CTG TGG CTC GGC TCC CTG AAG TCC AAC ATC 25712 Arg Thr Ala Asp Arg Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Ile 1890 1895 1900 GGG CAC ACC CAG GCC GCC GCC GGC GTG GCG GGC GTC ATC AAG ATG GTG 25760 Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val 1905 1910 1915 CTC GCG CTG GGC AAC GAG ACA CTG CCG CGC ACC CTG CAC GTG GAT GAG 25808 Leu Ala Leu Gly Asn Glu Thr Leu Pro Arg Thr Leu His Val Asp Glu 1920 1925 1930 CCC ACA CCG CGC GTG GAC TGG TCC TCT GGC GCG GTC TCC CTG CTC ACC 25856 Pro Thr Pro Arg Val Asp Trp Ser Ser Gly Ala Val Ser Leu Leu Thr 1935 1940 1945 GAG CCG GTG GAC TGG CCC GCC GGC CCG TCC GCG CCG CGC CGT GCG GCC 25904 Glu Pro Val Asp Trp Pro Ala Gly Pro Ser Ala Pro Arg Arg Ala Ala 1950 1955 1960 1965 GTG TCC TCG TTC GGC ATC AGC GGC ACC AAC GCC CAC ACG ATC CTG GAG 25952 Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Thr Ile Leu Glu 1970 1975 1980 CAG GCC CCC GTC CCC GCG GAG TCC CGC CCC GGG ACG GAG CCG GCG GAC 26000 Gln Ala Pro Val Pro Ala Glu Ser Arg Pro Gly Thr Glu Pro Ala Asp 1985 1990 1995 GGC ACG GGC GCG TGG GAG AAC GTG ACC GTT CCG CTG CTG CTG TCC GGC 26048 Gly Thr Gly Ala Trp Glu Asn Val Thr Val Pro Leu Leu Leu Ser Gly 2000 2005 2010 CAC ACC GAG GCG GCG CTG CGC GAG CAG AGC ACG AGG CTG CTG AAC GAC 26096 His Thr Glu Ala Ala Leu Arg Glu Gln Ser Thr Arg Leu Leu Asn Asp 2015 2020 2025 CTG CTG GAG CAC CCG GAC GAG CAC CCG GCC GAC GTC GGC TAC ACC CTG 26144 Leu Leu Glu His Pro Asp Glu His Pro Ala Asp Val Gly Tyr Thr Leu 2030 2035 2040 2045 ATC ACC GGC AGG GCC CAC TTC GGG CAC CGG GCC GCC GTG ATC GGC GAG 26192 Ile Thr Gly Arg Ala His Phe Gly His Arg Ala Ala Val Ile Gly Glu 2050 2055 2060 AGC CGG GAA GAA CTG CTC GAC GCC CTG AAG GCT CTG GCC GAG GGC CGC 26240 Ser Arg Glu Glu Leu Leu Asp Ala Leu Lys Ala Leu Ala Glu Gly Arg 2065 2070 2075 GAG CAC CAC ACC GTG GTA CGG GGC GAC GGG ACG GCC CAC CCG GAC CGG 26288 Glu His His Thr Val Val Arg Gly Asp Gly Thr Ala His Pro Asp Arg 2080 2085 2090 CGC GTG GTC TTC GTC TTC CCC GGG CAG GGC TCG CAG TGG CCG TCG ATG 26336 Arg Val Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Pro Ser Met 2095 2100 2105 GCC CGG GAC CTG CTC GAC CGC GCG CCC GCC TTC CGC GAG ACG GCG AAG 26384 Ala Arg Asp Leu Leu Asp Arg Ala Pro Ala Phe Arg Glu Thr Ala Lys 2110 2115 2120 2125 GCC TGC GAC GCC GCG CTG AGC GTC CAT CTG GAC TGG TCC GTG CTC GAT 26432 Ala Cys Asp Ala Ala Leu Ser Val His Leu Asp Trp Ser Val Leu Asp 2130 2135 2140 GTC CTC CAG GAG AAG CCG GAC GCG CCG CCG CTG AGC CGG GTC GAC GTG 26480 Val Leu Gln Glu Lys Pro Asp Ala Pro Pro Leu Ser Arg Val Asp Val 2145 2150 2155 GTG CAG CCC GTG CTG TTC ACG ATG ATG CTG TCG CTC GCC GCC TGC TGG 26528 Val Gln Pro Val Leu Phe Thr Met Met Leu Ser Leu Ala Ala Cys Trp 2160 2165 2170 CGG GAC CTC GGC GTC CAC CCG GCC GCC GTG GTG GGC CAC TCC CAG GGA 26576 Arg Asp Leu Gly Val His Pro Ala Ala Val Val Gly His Ser Gln Gly 2175 2180 2185 GAG ATC GCG GCG GCC TGC GTG GCC GGC GCG CTC TCC CTG GAG GAC GCG 26624 Glu Ile Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu Glu Asp Ala 2190 2195 2200 2205 GCG CGG ATC GTG GCG CTG CGC AGC CGG GCA TGG CTC ACA CTG GCC GGC 26672 Ala Arg Ile Val Ala Leu Arg Ser Arg Ala Trp Leu Thr Leu Ala Gly 2210 2215 2220 AAG GGC GGC ATG GCC GCC GTC TCC CTG CCG GAA GCC CGG CTG CGC GAG 26720 Lys Gly Gly Met Ala Ala Val Ser Leu Pro Glu Ala Arg Leu Arg Glu 2225 2230 2235 CGG ATC GAG CGG TTC GGG CAG CGG CTG TCG GTG GCC GCG GTG AAC AGC 26768 Arg Ile Glu Arg Phe Gly Gln Arg Leu Ser Val Ala Ala Val Asn Ser 2240 2245 2250 CCG GGC ACG GCG GCG GTC GCC GGT GAC GTG GAC GCG CTG CGG GAA CTG 26816 Pro Gly Thr Ala Ala Val Ala Gly Asp Val Asp Ala Leu Arg Glu Leu 2255 2260 2265 CTG GCG GAG CTG ACC GCG GAG GGC ATC CGG GCC AAG CCG ATC CCC GGC 26864 Leu Ala Glu Leu Thr Ala Glu Gly Ile Arg Ala Lys Pro Ile Pro Gly 2270 2275 2280 2285 GTG GAC ACG GCC GGC CAC TCC GCG CAG GTG GAC GGC CTG AAG GAG CAT 26912 Val Asp Thr Ala Gly His Ser Ala Gln Val Asp Gly Leu Lys Glu His 2290 2295 2300 CTC TTC GAG GTG CTG GCG CCG GTC TCC CCG CGC TCC TCG GAC ATC CCG 26960 Leu Phe Glu Val Leu Ala Pro Val Ser Pro Arg Ser Ser Asp Ile Pro 2305 2310 2315 TTC TAC TCG ACG GTG ACG GGC GCG CCG CTG GAC ACC GAG CGG CTG GAC 27008 Phe Tyr Ser Thr Val Thr Gly Ala Pro Leu Asp Thr Glu Arg Leu Asp 2320 2325 2330 GCC GGG TAC TGG TAC CGC AAC ATG CGG GAG CCC GTG GAG TTC GAG AAG 27056 Ala Gly Tyr Trp Tyr Arg Asn Met Arg Glu Pro Val Glu Phe Glu Lys 2335 2340 2345 GCC GTC AGG GCA CTG ATC GCC GAC GGC TAC GAC CTG TTC CTG GAG TGC 27104 Ala Val Arg Ala Leu Ile Ala Asp Gly Tyr Asp Leu Phe Leu Glu Cys 2350 2355 2360 2365 AAC CCG CAC CCG ATG CTC GCC ATG TCG CTG GAC GAG ACA CTC ACC GAC 27152 Asn Pro His Pro Met Leu Ala Met Ser Leu Asp Glu Thr Leu Thr Asp 2370 2375 2380 AGC GGC GGC CAC GGC ACC GTG ATG CAC ACC CTC CGC CGG CAG AAG GGC 27200 Ser Gly Gly His Gly Thr Val Met His Thr Leu Arg Arg Gln Lys Gly 2385 2390 2395 AGC GCC AAG GAC TTC GGC ATG GCG CTC TGC CTC GCC TAT GTC AAC GGA 27248 Ser Ala Lys Asp Phe Gly Met Ala Leu Cys Leu Ala Tyr Val Asn Gly 2400 2405 2410 CTG GAG ATC GAC GGA GAA GCC CTC TTC GGC CCC GAC TCA CGC CGG GTG 27296 Leu Glu Ile Asp Gly Glu Ala Leu Phe Gly Pro Asp Ser Arg Arg Val 2415 2420 2425 AAC CCG CCG ACG TAC CCG TTC CAG CGG GAG CGC TAC TGG TAC CAC CCC 27344 Asn Pro Pro Thr Tyr Pro Phe Gln Arg Glu Arg Tyr Trp Tyr His Pro 2430 2435 2440 2445 ACG AGC GGC AGG CGC GGC GAC ATC ACG GCG GCC GGC GTG GCC GAG GCG 27392 Thr Ser Gly Arg Arg Gly Asp Ile Thr Ala Ala Gly Val Ala Glu Ala 2450 2455 2460 GAG CAC CCG CTG CTC GGC GCC GGC GTC GAA CTC CCG GAG ACC GGG GGC 27440 Glu His Pro Leu Leu Gly Ala Gly Val Glu Leu Pro Glu Thr Gly Gly 2465 2470 2475 ACG GTG TAC ACC GCG CGG TTC GGC CCG GAC AGC CGG CCG TGG CTG GCC 27488 Thr Val Tyr Thr Ala Arg Phe Gly Pro Asp Ser Arg Pro Trp Leu Ala 2480 2485 2490 GAC CAC GCG CTG CTG GGC ACC GTG CTG CTG CCC GGC ACG GCA ATC CTG 27536 Asp His Ala Leu Leu Gly Thr Val Leu Leu Pro Gly Thr Ala Ile Leu 2495 2500 2505 GAC CTG GTG CTG TGG GCG GGC GAA CGC TCC GGC TGC GGC CGC GTC GGT 27584 Asp Leu Val Leu Trp Ala Gly Glu Arg Ser Gly Cys Gly Arg Val Gly 2510 2515 2520 2525 GAA CTG GCG CTC CAG GCA CCG CTG GTC CTG CCG GAC AGC GGC GAC GTC 27632 Glu Leu Ala Leu Gln Ala Pro Leu Val Leu Pro Asp Ser Gly Asp Val 2530 2535 2540 GAA CTG CGG CTG CTG GTC GGC GGC CCG GAC GAG GAG AAA CGG CGC ACC 27680 Glu Leu Arg Leu Leu Val Gly Gly Pro Asp Glu Glu Lys Arg Arg Thr 2545 2550 2555 GTC ACC GTG CAC GCG CGG CCC GCG GCG GCC GGC GCC GAG GCG CCG TGG 27728 Val Thr Val His Ala Arg Pro Ala Ala Ala Gly Ala Glu Ala Pro Trp 2560 2565 2570 ACC CGG CAC GCC GAA GCC GTG GTG CTG CCC GCC ACC GGC GAG GAG CCG 27776 Thr Arg His Ala Glu Ala Val Val Leu Pro Ala Thr Gly Glu Glu Pro 2575 2580 2585 ACC CCC GCC CCG CGC CCC GTC CCC GAG CCG GCG GGC ACC ACG GAC CCC 27824 Thr Pro Ala Pro Arg Pro Val Pro Glu Pro Ala Gly Thr Thr Asp Pro 2590 2595 2600 2605 GCC GCG TTC TAC GCG GAG TTC GCC GAG CGC GGC TAC GAC TAC GGC CCG 27872 Ala Ala Phe Tyr Ala Glu Phe Ala Glu Arg Gly Tyr Asp Tyr Gly Pro 2610 2615 2620 GCC TTC CAG GGC TTC ACC GCC GGA GCG CGC CAC GGC GAG GAC GTC GTC 27920 Ala Phe Gln Gly Phe Thr Ala Gly Ala Arg His Gly Glu Asp Val Val 2625 2630 2635 GCC GAG GTG GCG CTG CCC AGC GGC CTG GTG GCG GAC GCC CGT CAC CAC 27968 Ala Glu Val Ala Leu Pro Ser Gly Leu Val Ala Asp Ala Arg His His 2640 2645 2650 CGG CTG CAC CCG GCG CTG CTC GAC GCC GCG CTC CAG GCG ATG ATC CTC 28016 Arg Leu His Pro Ala Leu Leu Asp Ala Ala Leu Gln Ala Met Ile Leu 2655 2660 2665 GGC ACG TTC TTT GCC GAC GAC GGC CGC GCC CGG ATG CCG TTC GCG GTG 28064 Gly Thr Phe Phe Ala Asp Asp Gly Arg Ala Arg Met Pro Phe Ala Val 2670 2675 2680 2685 CGC GGA GTA CGG CTG CAC ACG GCC GGC GCC GAC CGG CTG CGC GTC CTG 28112 Arg Gly Val Arg Leu His Thr Ala Gly Ala Asp Arg Leu Arg Val Leu 2690 2695 2700 ATC TCC CCG GCG GGC GAC GAG ACC GTA CGG CTG CTC TGC ACC GAC CTC 28160 Ile Ser Pro Ala Gly Asp Glu Thr Val Arg Leu Leu Cys Thr Asp Leu 2705 2710 2715 GCG ACC GGC GCC CCC GTG CTG GAG ATC GAC GAA CTG GTC GTC CGC CCG 28208 Ala Thr Gly Ala Pro Val Leu Glu Ile Asp Glu Leu Val Val Arg Pro 2720 2725 2730 GTG TCC GGC GAG CAG TTG GCG GCC GGC GCC CCG GGC CGC AAC GGC GGC 28256 Val Ser Gly Glu Gln Leu Ala Ala Gly Ala Pro Gly Arg Asn Gly Gly 2735 2740 2745 GAG CTG TAC CGG GTC GAC TGG ACG GTG CTG CCG GAG CCC GCC GAG GTG 28304 Glu Leu Tyr Arg Val Asp Trp Thr Val Leu Pro Glu Pro Ala Glu Val 2750 2755 2760 2765 CCC GCG CCG CGC TGG GCC CTC CTC GGC GAG GAC CAC GCC GGC CTG GCC 28352 Pro Ala Pro Arg Trp Ala Leu Leu Gly Glu Asp His Ala Gly Leu Ala 2770 2775 2780 GAT GTG CTC GGA GGG ACG GGC GGC GGC TGC GAG CGG TAC GAC ACC CTC 28400 Asp Val Leu Gly Gly Thr Gly Gly Gly Cys Glu Arg Tyr Asp Thr Leu 2785 2790 2795 ACC GGC CTG CTG GAG GCC ACC ACC CGG TCG GCC GGC GGA ATC CTG CCC 28448 Thr Gly Leu Leu Glu Ala Thr Thr Arg Ser Ala Gly Gly Ile Leu Pro 2800 2805 2810 GAC ATC GTC GCG CTC TCC TTG CCC ACC GCC CCG GAG CCC GGC CCC CAG 28496 Asp Ile Val Ala Leu Ser Leu Pro Thr Ala Pro Glu Pro Gly Pro Gln 2815 2820 2825 GCG GTG CGC GAG GTG CTG TCC CAG GCG CTC GAC GCC GCC CAG GCG TGG 28544 Ala Val Arg Glu Val Leu Ser Gln Ala Leu Asp Ala Ala Gln Ala Trp 2830 2835 2840 2845 CTG GCC GCC GGC GCC GAG ACC GCC TCC GCC CGG CTG GTG TTC GTC ACC 28592 Leu Ala Ala Gly Ala Glu Thr Ala Ser Ala Arg Leu Val Phe Val Thr 2850 2855 2860 GGC GGC GCG GTG GCC ACC ACG GCG GAC GAA ACC GTG CGC GAC ATC GCG 28640 Gly Gly Ala Val Ala Thr Thr Ala Asp Glu Thr Val Arg Asp Ile Ala 2865 2870 2875 GCG GCC GCC GTC TGG GGC CTG GTC CGC TCG GCG CAG TCC GAG GAA CCC 28688 Ala Ala Ala Val Trp Gly Leu Val Arg Ser Ala Gln Ser Glu Glu Pro 2880 2885 2890 GAC CGC ATG GTC CTG CTC GAC CTG GAC GGC GAG CGG CCC ACC GCG CGG 28736 Asp Arg Met Val Leu Leu Asp Leu Asp Gly Glu Arg Pro Thr Ala Arg 2895 2900 2905 ACG CTG GCG GCG GCG CTC GCG TCC GGC GAA CCG CAA CTC GCC GTG CGC 28784 Thr Leu Ala Ala Ala Leu Ala Ser Gly Glu Pro Gln Leu Ala Val Arg 2910 2915 2920 2925 GGC TCC ACG GTG GCC GCT CCC CGG CTG GCC CCG GCC GGG CCC GGC CCG 28832 Gly Ser Thr Val Ala Ala Pro Arg Leu Ala Pro Ala Gly Pro Gly Pro 2930 2935 2940 GAG GAC CTC GTA CCG CCC GCC GGC ACC ACC GCC TGG CGG CTC ACC CCC 28880 Glu Asp Leu Val Pro Pro Ala Gly Thr Thr Ala Trp Arg Leu Thr Pro 2945 2950 2955 GGC GGG GGG ACG CTG GAG GAA CTG TCG CTC GCG CCC GCC CCC GAC GCG 28928 Gly Gly Gly Thr Leu Glu Glu Leu Ser Leu Ala Pro Ala Pro Asp Ala 2960 2965 2970 GAG GAA CCA CTG GCA CCG GGC CAG GTA CGC ATC GCC GTC CGC GCG GCG 28976 Glu Glu Pro Leu Ala Pro Gly Gln Val Arg Ile Ala Val Arg Ala Ala 2975 2980 2985 GGC GTG AAC TTC CGC GAC GCC CTG ATC GCC CTC GGC ATG TAC CCG GGC 29024 Gly Val Asn Phe Arg Asp Ala Leu Ile Ala Leu Gly Met Tyr Pro Gly 2990 2995 3000 3005 AAG GGA ACC ATG GGC GCC GAG GGA GCC GGC GTC GTC GTC GAG ACC GCC 29072 Lys Gly Thr Met Gly Ala Glu Gly Ala Gly Val Val Val Glu Thr Ala 3010 3015 3020 CCC GAT GTC ACC GGC CTC TCC GCC GGA GAC CGC GTG CTC GGC ATG TGG 29120 Pro Asp Val Thr Gly Leu Ser Ala Gly Asp Arg Val Leu Gly Met Trp 3025 3030 3035 AAC GGC GGC TTC GGG CCC CTC GTG GTG GCC GAC CAC CGC ATG GTG GCC 29168 Asn Gly Gly Phe Gly Pro Leu Val Val Ala Asp His Arg Met Val Ala 3040 3045 3050 CCG ATC CCC CAC GGC TGG TCG TAC GCC GAG GCG GCC TCC GTG CCC GCC 29216 Pro Ile Pro His Gly Trp Ser Tyr Ala Glu Ala Ala Ser Val Pro Ala 3055 3060 3065 GTG CTC CTC ACC TCC TAC TAC GCG CTG ACC CGG CTG GCC CGG GCC CGC 29264 Val Leu Leu Thr Ser Tyr Tyr Ala Leu Thr Arg Leu Ala Arg Ala Arg 3070 3075 3080 3085 ACC GGA CAG ACC GTC CTC GTC CAC GCC GCC GCC GGC GGT GTC GGC ATG 29312 Thr Gly Gln Thr Val Leu Val His Ala Ala Ala Gly Gly Val Gly Met 3090 3095 3100 GCG ACC CTC CAA CTC GCC CGC CAC CTC GGC CTG GAG GTG TAC GCC ACC 29360 Ala Thr Leu Gln Leu Ala Arg His Leu Gly Leu Glu Val Tyr Ala Thr 3105 3110 3115 GCG AGC ACC GGC AAA TGG GAC GCC CTG CAG AAG CAC GGC ATC CCC GAC 29408 Ala Ser Thr Gly Lys Trp Asp Ala Leu Gln Lys His Gly Ile Pro Asp 3120 3125 3130 GAC CGC ATC GCC GAC TCC CGC ACC CTG GAC TTC GCC GAG CGC TTC CTG 29456 Asp Arg Ile Ala Asp Ser Arg Thr Leu Asp Phe Ala Glu Arg Phe Leu 3135 3140 3145 TCC CGG ACG GGC GGC CGG GGT GTC GAC ATC GTG CTG AAC TCC CTG GCC 29504 Ser Arg Thr Gly Gly Arg Gly Val Asp Ile Val Leu Asn Ser Leu Ala 3150 3155 3160 3165 GGC GAG TTC GTC GAC GCC TCA CTG CGG CTG CTG CCG CGC GGC GGG CAC 29552 Gly Glu Phe Val Asp Ala Ser Leu Arg Leu Leu Pro Arg Gly Gly His 3170 3175 3180 TTC CTG GAA CTC GGC AAG GCC GAC GTC CGC GAC CCC CGG CGG ATC GCC 29600 Phe Leu Glu Leu Gly Lys Ala Asp Val Arg Asp Pro Arg Arg Ile Ala 3185 3190 3195 GCC GCC CAT CCG GGC ACC GAC TAC CGG GCG TTC GAC CTG GTG CAG GCC 29648 Ala Ala His Pro Gly Thr Asp Tyr Arg Ala Phe Asp Leu Val Gln Ala 3200 3205 3210 GGT CCC GAC ACC GTC GGG GAG ATG CTC GGG GAA CTG CTG GAA CTG TTC 29696 Gly Pro Asp Thr Val Gly Glu Met Leu Gly Glu Leu Leu Glu Leu Phe 3215 3220 3225 GCG GCC GGA GCG CTG CGC CCG CTG CCG CTC ACC GCC TAC GGC ATA CGC 29744 Ala Ala Gly Ala Leu Arg Pro Leu Pro Leu Thr Ala Tyr Gly Ile Arg 3230 3235 3240 3245 GAC GCC CGC ACC GCC TTG CGC ACC CTC AGC CAG GCC CGG CAC ACC GGC 29792 Asp Ala Arg Thr Ala Leu Arg Thr Leu Ser Gln Ala Arg His Thr Gly 3250 3255 3260 AAG CTC GTG CTG ACG GTG CCT GCC GGA TTC GAC ACC CAC CGC ACG GTG 29840 Lys Leu Val Leu Thr Val Pro Ala Gly Phe Asp Thr His Arg Thr Val 3265 3270 3275 CTC CTC ACC GGC GGC ACG GGC ACG CTC GGC CAG ACA CTC GCC CGC CAT 29888 Leu Leu Thr Gly Gly Thr Gly Thr Leu Gly Gln Thr Leu Ala Arg His 3280 3285 3290 CTG GTC AAC CGC CAC GGC GTA CGG CAC CTG CTG CTC GCC GGC CGC ACC 29936 Leu Val Asn Arg His Gly Val Arg His Leu Leu Leu Ala Gly Arg Thr 3295 3300 3305 GGC GCG GCG GCC GAG GGC GTC GCG GAA CTG ATT GGT GAA CTG GGC GAG 29984 Gly Ala Ala Ala Glu Gly Val Ala Glu Leu Ile Gly Glu Leu Gly Glu 3310 3315 3320 3325 TTG GGC GCC GAG GTC CGG GTC GCG GCC TGC GAC GCG GCC GAC CGG CAG 30032 Leu Gly Ala Glu Val Arg Val Ala Ala Cys Asp Ala Ala Asp Arg Gln 3330 3335 3340 CGG CTC ACC GAA CTC CTC GCC GGA ATC CCC GTC GAG CAC CCG CTC GGC 30080 Arg Leu Thr Glu Leu Leu Ala Gly Ile Pro Val Glu His Pro Leu Gly 3345 3350 3355 GCC GTC GTC CAC GCC GCG GGC ACC CTC GAC GAC GGC ACC ATC CCC TCA 30128 Ala Val Val His Ala Ala Gly Thr Leu Asp Asp Gly Thr Ile Pro Ser 3360 3365 3370 CTG ACC GGC GAG AAC ATC GAC AAC GTG CTG CGG CCC AAG GCC GAC GCC 30176 Leu Thr Gly Glu Asn Ile Asp Asn Val Leu Arg Pro Lys Ala Asp Ala 3375 3380 3385 GTG CTC AAC CTG CAC GAG CTG ACC CGC GAC GCC GAC CTC TCG GCG TTC 30224 Val Leu Asn Leu His Glu Leu Thr Arg Asp Ala Asp Leu Ser Ala Phe 3390 3395 3400 3405 GTC CTC TAC TCG TCC TCC TCG GCG CTG CTC GGC AGC CCC GGC CAG GGC 30272 Val Leu Tyr Ser Ser Ser Ser Ala Leu Leu Gly Ser Pro Gly Gln Gly 3410 3415 3420 GCC TAC GCC GCG GCC AAC GCC TTC CTG GAC GGC TTC GCC CGA TAC CGC 30320 Ala Tyr Ala Ala Ala Asn Ala Phe Leu Asp Gly Phe Ala Arg Tyr Arg 3425 3430 3435 AAG GGC CTC GGG CTG CCG GCG CTC TCG CTG GCC TGG GGA CTG TGG GGC 30368 Lys Gly Leu Gly Leu Pro Ala Leu Ser Leu Ala Trp Gly Leu Trp Gly 3440 3445 3450 AGC AAC AGC CGC ATG GCG GGC CAC CTC GAC CAG TCG GGC ATG CAA CGG 30416 Ser Asn Ser Arg Met Ala Gly His Leu Asp Gln Ser Gly Met Gln Arg 3455 3460 3465 CGC CTG AAC CGG AGC GGC ATC ATG GCG CTC ACC GAC GCC GAG GGC CTC 30464 Arg Leu Asn Arg Ser Gly Ile Met Ala Leu Thr Asp Ala Glu Gly Leu 3470 3475 3480 3485 GCC CTG TTC GAC GCC GCA CAG GAC GGC GGG GAC GCG CTG CTG GTG CCG 30512 Ala Leu Phe Asp Ala Ala Gln Asp Gly Gly Asp Ala Leu Leu Val Pro 3490 3495 3500 ATG CGG CTC AAC CGG ACG GCC CTT CGC GCC TCG GGA CGG ATC ACC CCG 30560 Met Arg Leu Asn Arg Thr Ala Leu Arg Ala Ser Gly Arg Ile Thr Pro 3505 3510 3515 TTC CTC AGC GGC TTG GCC GGC GGC GGG CCG GCG GCG GGG GAG AGG CGC 30608 Phe Leu Ser Gly Leu Ala Gly Gly Gly Pro Ala Ala Gly Glu Arg Arg 3520 3525 3530 CCC GAG GTG GCA GCC GTA TCC GGG ACA CTC GCG GAA CGG CTG ACC GGG 30656 Pro Glu Val Ala Ala Val Ser Gly Thr Leu Ala Glu Arg Leu Thr Gly 3535 3540 3545 CTC ACG GCA CAG GAA GGG CAC GCC CTC GTC CTG GCC GAG ATC CGC GCC 30704 Leu Thr Ala Gln Glu Gly His Ala Leu Val Leu Ala Glu Ile Arg Ala 3550 3555 3560 3565 CAC GCG GCG GCG GTG CTG GGC CAC GGC TCC GAC GAC TCG ATC CCC GAG 30752 His Ala Ala Ala Val Leu Gly His Gly Ser Asp Asp Ser Ile Pro Glu 3570 3575 3580 GAC CGG GCC TTC AAG GAC CTC GGC TTC GAC TCG CTC ACC GCC GTG GAG 30800 Asp Arg Ala Phe Lys Asp Leu Gly Phe Asp Ser Leu Thr Ala Val Glu 3585 3590 3595 ATG CGC AAC CGG CTG AGC GCG GCC ACC GGC CTC CGG CTG CCC GCC ACC 30848 Met Arg Asn Arg Leu Ser Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr 3600 3605 3610 CTC GTC TTC GAC CAC CCG ACC CCG GGC GAG CTG GCC GGC CAC CTG AGT 30896 Leu Val Phe Asp His Pro Thr Pro Gly Glu Leu Ala Gly His Leu Ser 3615 3620 3625 GCT GAA CTG TCC GCC GAC GAT GCC CCG GGC AGC GCC TCC CCG CTT ACC 30944 Ala Glu Leu Ser Ala Asp Asp Ala Pro Gly Ser Ala Ser Pro Leu Thr 3630 3635 3640 3645 GAA CTC GAC CGT TTC GAA GCC CTG TTC ACC GCT CTC GCA CCG GGG ACC 30992 Glu Leu Asp Arg Phe Glu Ala Leu Phe Thr Ala Leu Ala Pro Gly Thr 3650 3655 3660 ACC AAG GAC ACC CCG GGC GGG GCC GGG GCA CTG ATG ATC GAC GAG GCC 31040 Thr Lys Asp Thr Pro Gly Gly Ala Gly Ala Leu Met Ile Asp Glu Ala 3665 3670 3675 GAG CGC CAA GAG ATC GCC GGG CGG CTC GCG GCG CTG GCC GGT CTG TGG 31088 Glu Arg Gln Glu Ile Ala Gly Arg Leu Ala Ala Leu Ala Gly Leu Trp 3680 3685 3690 AAC CGG CTG CAC GGC ACC ACG ACG GCT CCT GAG GAC GGC GAC ACC GTC 31136 Asn Arg Leu His Gly Thr Thr Thr Ala Pro Glu Asp Gly Asp Thr Val 3695 3700 3705 GCG GAC GCC CTG GAA GCC GCG GAC GAC CAC GAG ATC TTC GCA TTC CTC 31184 Ala Asp Ala Leu Glu Ala Ala Asp Asp His Glu Ile Phe Ala Phe Leu 3710 3715 3720 3725 GAC GAG CGG TTC TGA GCCCGCCCCA GCGACAGCAC AGGTGAAAAC AC ATG GCC 31237 Asp Glu Arg Phe * Met Ala 3730 1 AAC GCG AAC GAG CAG CAA CTC CGT GCC TAT CTG AAG CGA GCG ACG ACC 31285 Asn Ala Asn Glu Gln Gln Leu Arg Ala Tyr Leu Lys Arg Ala Thr Thr 5 10 15 GAA CTC CAC CGT ACC TCC GAA CAA CTG AGG GAG GAG CGG GCA CGG GCC 31333 Glu Leu His Arg Thr Ser Glu Gln Leu Arg Glu Glu Arg Ala Arg Ala 20 25 30 CAC GAG CCG ATC GCC GTC GTC GGC ATG GCC TGC CGC TAC CCC GGA GGC 31381 His Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg Tyr Pro Gly Gly 35 40 45 50 GCG AAC ACC CCC GAA CAG TTC TGG GAA CTG CTC GAC ACC GGC ACC GAC 31429 Ala Asn Thr Pro Glu Gln Phe Trp Glu Leu Leu Asp Thr Gly Thr Asp 55 60 65 GCC GCC GCG CCG ATG CCC TCC GAC CGG GGA TGG GAC ACC CAC GGG CTG 31477 Ala Ala Ala Pro Met Pro Ser Asp Arg Gly Trp Asp Thr His Gly Leu 70 75 80 TAC GAC CCC GAC CCG GCG GCA GCG GGG CGC ACC TAC TGC CGG GAG GGC 31525 Tyr Asp Pro Asp Pro Ala Ala Ala Gly Arg Thr Tyr Cys Arg Glu Gly 85 90 95 GGC TTC CTC CAC GAC GCG GGC GAC TTC GAC GCG GAC TTC TTC GGG ATT 31573 Gly Phe Leu His Asp Ala Gly Asp Phe Asp Ala Asp Phe Phe Gly Ile 100 105 110 TCG CCG CGT GAG GCG GTG GCG ATG GAT CCG CAG CAG CGG CTG TTG CTG 31621 Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Leu Leu 115 120 125 130 GAG ACC TCC TGG GAG GCG ATC GAA GCG GCC GGT ATC GAC CCG CGA GGA 31669 Glu Thr Ser Trp Glu Ala Ile Glu Ala Ala Gly Ile Asp Pro Arg Gly 135 140 145 CTC CGC GGC AGC CGC ACC GGG GTG TAC GTG GGC GCC TGG GAC AGC GGC 31717 Leu Arg Gly Ser Arg Thr Gly Val Tyr Val Gly Ala Trp Asp Ser Gly 150 155 160 TAC ACC GGC CAG GCG CAC GCG CCC TCG GCC GAG TTG GAG GCC GAC CTG 31765 Tyr Thr Gly Gln Ala His Ala Pro Ser Ala Glu Leu Glu Ala Asp Leu 165 170 175 CTG ACC GGC GGC GTC GTC AGC TTC ACC TCC GGC CGT ATC GCC TAC ACG 31813 Leu Thr Gly Gly Val Val Ser Phe Thr Ser Gly Arg Ile Ala Tyr Thr 180 185 190 CTG GGG CTG GAG GGT CCG GCC TTG ACC GTG GAC ACC GCG TGT TCG TCG 31861 Leu Gly Leu Glu Gly Pro Ala Leu Thr Val Asp Thr Ala Cys Ser Ser 195 200 205 210 TCG CTG GTC GCC CTG CAC AAC GCG GCG CAG GCG CTG CGG CGC GGC GAA 31909 Ser Leu Val Ala Leu His Asn Ala Ala Gln Ala Leu Arg Arg Gly Glu 215 220 225 TGC GAC CTG GCG TTG GCC GGT GGT GTG ACG GTG ATG GCG ACC CCG GCG 31957 Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Ala 230 235 240 GTG TTC GTC CAG TTC GCC CGG CAG CGA GGG CTG GCG CCG GAC GGC CGC 32005 Val Phe Val Gln Phe Ala Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg 245 250 255 TGC AAG GCG TTC GCC GAC GCC GCC GAC GGC TTC GGC CCC GCC GAG GGT 32053 Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Phe Gly Pro Ala Glu Gly 260 265 270 GTG GGG ATG GTG CTG GTG GAG CGG TTG TCG GAT GCC CGG CGG TTG GGG 32101 Val Gly Met Val Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly 275 280 285 290 CAT CCG GTG TTG GCG GTG GTG TGT GGG TCG GCG GTG AAT CAG GAC GGT 32149 His Pro Val Leu Ala Val Val Cys Gly Ser Ala Val Asn Gln Asp Gly 295 300 305 GCG TCG AAT GGT TTG ACG GCG CCG AGT GGT CCG TCG CAG GAG CGG GTG 32197 Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ser Gln Glu Arg Val 310 315 320 ATT CGT CAG GCG TTG GGG AAT GCG CGG TTG ACG GTG GCG GAT GTG GAT 32245 Ile Arg Gln Ala Leu Gly Asn Ala Arg Leu Thr Val Ala Asp Val Asp 325 330 335 GTG GTG GAG GCG CAT GGG ACG GGG ACG CGG CTG GGT GAT CCG ATC GAG 32293 Val Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu 340 345 350 GCG CAG GCG TTG CTG GGG ACG TAT GGG CGG GAT CGT GAT GGT GGG CGT 32341 Ala Gln Ala Leu Leu Gly Thr Tyr Gly Arg Asp Arg Asp Gly Gly Arg 355 360 365 370 CCG GTG TGG TTG GGG TCG TTG AAG TCG AAT ATT GGT CAT GCT CAG GCG 32389 Pro Val Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala 375 380 385 GCT GCG GGG GTG GCT GGT GTG ATC AAG ATG GTG TTG GCG ATG CGG TAT 32437 Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Leu Ala Met Arg Tyr 390 395 400 GGG TGG TTG CCG CGG ACG TTG CAT GTG GAT GAG CCG AGC CGG CAT GTG 32485 Gly Trp Leu Pro Arg Thr Leu His Val Asp Glu Pro Ser Arg His Val 405 410 415 GAC TGG TCG GCT GGT GGT GTG CGG TTG CTG ACC GAG GCG CGG GAG TGG 32533 Asp Trp Ser Ala Gly Gly Val Arg Leu Leu Thr Glu Ala Arg Glu Trp 420 425 430 CCG GGG GTG GAC CGG CCG CGT CGG GCG GCG GTC TCC GCC TTT GGT GTC 32581 Pro Gly Val Asp Arg Pro Arg Arg Ala Ala Val Ser Ala Phe Gly Val 435 440 445 450 AGT GGT ACC AAC GCC CAT CTG ATC CTC GAA GCC CCC GAC ACC GCC GAG 32629 Ser Gly Thr Asn Ala His Leu Ile Leu Glu Ala Pro Asp Thr Ala Glu 455 460 465 GCG GAG AGC GCC ACG ACC CCG GTC CGC TCT GAG GTG TCG GAG TCT GCT 32677 Ala Glu Ser Ala Thr Thr Pro Val Arg Ser Glu Val Ser Glu Ser Ala 470 475 480 GCG GTC CTC GAT GCC CGC AGT GGT GTG GTG CCG GTG GTG GTT TCG GGG 32725 Ala Val Leu Asp Ala Arg Ser Gly Val Val Pro Val Val Val Ser Gly 485 490 495 CGT TCG CGG GTG GTG GTG CGG GAG GCT GCG GGC CGG TTG GCG GAG GTG 32773 Arg Ser Arg Val Val Val Arg Glu Ala Ala Gly Arg Leu Ala Glu Val 500 505 510 GTG GAG GCC GGT GGT GTG GGG CTG GCG GAT GTG GCG GTG ACG ATG GCG 32821 Val Glu Ala Gly Gly Val Gly Leu Ala Asp Val Ala Val Thr Met Ala 515 520 525 530 GGC CGG TCG CGG TTT GGG TAT CGG GCG GTT GTG CTG GCT CGG GGT GAG 32869 Gly Arg Ser Arg Phe Gly Tyr Arg Ala Val Val Leu Ala Arg Gly Glu 535 540 545 GCT GAG CTT GCC GGG CGT TTG CGG GCG TTG GCG GGG GGT GAT CCG GAC 32917 Ala Glu Leu Ala Gly Arg Leu Arg Ala Leu Ala Gly Gly Asp Pro Asp 550 555 560 GCG GGT GTG GTC ACG GGT GCG GTG GTG GAC CCG GAG ACG GGG TCC GGT 32965 Ala Gly Val Val Thr Gly Ala Val Val Asp Pro Glu Thr Gly Ser Gly 565 570 575 GGT GGG GGG GTG GTG TTG GTT TTC CCT GGT CAG GGG ACG CAG TGG GTG 33013 Gly Gly Gly Val Val Leu Val Phe Pro Gly Gln Gly Thr Gln Trp Val 580 585 590 GGG ATG GGT GCG GGG CTG CTG GGG TCT TCG GAG GTG TTT GCG GCG TCG 33061 Gly Met Gly Ala Gly Leu Leu Gly Ser Ser Glu Val Phe Ala Ala Ser 595 600 605 610 ATG CGG GAG TGT GCG CGG GCG CTG AGT GTT CAT GTG GGG TGG GAT TTG 33109 Met Arg Glu Cys Ala Arg Ala Leu Ser Val His Val Gly Trp Asp Leu 615 620 625 CTG GAG GTG GTG TCG GGC GGG GCC GGG TTG GAG CGG GTG GAT GTG GTG 33157 Leu Glu Val Val Ser Gly Gly Ala Gly Leu Glu Arg Val Asp Val Val 630 635 640 CAG CCG GTG ACG TGG GCG GTG ATG GTG TCG CTG GCC CGG TAC TGG CAG 33205 Gln Pro Val Thr Trp Ala Val Met Val Ser Leu Ala Arg Tyr Trp Gln 645 650 655 GCG ATG GGT GTG GAC GTG GCT GCG GTG GTG GGT CAT TCC CAG GGG GAG 33253 Ala Met Gly Val Asp Val Ala Ala Val Val Gly His Ser Gln Gly Glu 660 665 670 ATC GCT GCT GCC ACG GTG GCG GGG GCG TTG TCG CTG GAG GAT GCG GCG 33301 Ile Ala Ala Ala Thr Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala 675 680 685 690 GCT GTG GTC GCT CTG CGG GCG GGG TTG ATT GGC CGG TAT CTG GCG GGT 33349 Ala Val Val Ala Leu Arg Ala Gly Leu Ile Gly Arg Tyr Leu Ala Gly 695 700 705 CGT GGT GCG ATG GCG GCT GTT CCG CTG CCT GCC GGC GAG GTC GAG GCC 33397 Arg Gly Ala Met Ala Ala Val Pro Leu Pro Ala Gly Glu Val Glu Ala 710 715 720 GGG CTG GCG AAG TGG CCG GGT GTG GAG GTC GCG GCG GTC AAC GGT CCG 33445 Gly Leu Ala Lys Trp Pro Gly Val Glu Val Ala Ala Val Asn Gly Pro 725 730 735 GCG TCT ACG GTG GTT TCC GGG GAT CGG CGG GCG GTG GCC GGT TAT GTG 33493 Ala Ser Thr Val Val Ser Gly Asp Arg Arg Ala Val Ala Gly Tyr Val 740 745 750 GCC GTC TGT CAG GCG GAG GGT GTG CAG GCT CGG TTG ATA CCG GTG GAC 33541 Ala Val Cys Gln Ala Glu Gly Val Gln Ala Arg Leu Ile Pro Val Asp 755 760 765 770 TAC GCC TCT CAC TCC CGC CAT GTG GAG GAC CTG AAG GGC GAG TTG GAG 33589 Tyr Ala Ser His Ser Arg His Val Glu Asp Leu Lys Gly Glu Leu Glu 775 780 785 CGG GTG CTG TCC GGT ATC CGC CCC CGC AGT CCG CGG GTG CCG GTG TGT 33637 Arg Val Leu Ser Gly Ile Arg Pro Arg Ser Pro Arg Val Pro Val Cys 790 795 800 TCC ACC GTC GCC GGA GAG CAG CCG GGC GAG CCG GTT TTC GAT GCG GGG 33685 Ser Thr Val Ala Gly Glu Gln Pro Gly Glu Pro Val Phe Asp Ala Gly 805 810 815 TAT TGG TTC CGT AAT CTG CGG AAC CGG GTT GAG TTC TCC GCG GTG GTC 33733 Tyr Trp Phe Arg Asn Leu Arg Asn Arg Val Glu Phe Ser Ala Val Val 820 825 830 GGT GGT TTG TTG GAG GAG GGC CAC CGT CGG TTC ATC GAG GTC AGT GCC 33781 Gly Gly Leu Leu Glu Glu Gly His Arg Arg Phe Ile Glu Val Ser Ala 835 840 845 850 CAC CCG GTA CTC GTC CAT GCC ATT GAG CAG ACG GCC GAG GCC GCG GAC 33829 His Pro Val Leu Val His Ala Ile Glu Gln Thr Ala Glu Ala Ala Asp 855 860 865 CGG AGT GTC CAT GCC ACC GGG ACC CTG CGC CGC CAG GAC GAC AGC CCG 33877 Arg Ser Val His Ala Thr Gly Thr Leu Arg Arg Gln Asp Asp Ser Pro 870 875 880 CAC CGC CTG CTG ACC TCC ACC GCC GAG GCC TGG GCC CAC GGC GCC ACC 33925 His Arg Leu Leu Thr Ser Thr Ala Glu Ala Trp Ala His Gly Ala Thr 885 890 895 CTC ACC TGG GAC CCC GCC CTG CCC CCA GGC CAC CTC ACC ACC CTC CCC 33973 Leu Thr Trp Asp Pro Ala Leu Pro Pro Gly His Leu Thr Thr Leu Pro 900 905 910 ACC TAC CCC TTC AAC CAC CAC CAC TAC TGG CTC GAC ACC ACC CCC ACC 34021 Thr Tyr Pro Phe Asn His His His Tyr Trp Leu Asp Thr Thr Pro Thr 915 920 925 930 ACC CCC GCG ACG ACC ACC CAG AGC CCC ACC GAT GCC TGG CGC TAC CGC 34069 Thr Pro Ala Thr Thr Thr Gln Ser Pro Thr Asp Ala Trp Arg Tyr Arg 935 940 945 GTC ACC TGG AAA GCC CTG ACC GAA GAA TCC ACT CCG GCC TCG TCC CCC 34117 Val Thr Trp Lys Ala Leu Thr Glu Glu Ser Thr Pro Ala Ser Ser Pro 950 955 960 TCC GGT CAC TGG CTC CTC GTC ACA CCC CCG ACC CCC GAA GGC CGC ACG 34165 Ser Gly His Trp Leu Leu Val Thr Pro Pro Thr Pro Glu Gly Arg Thr 965 970 975 CTC GGG GAC CGG GCC GCC GGC GCC CTC GCA CGT CAG GGG GCC ACG GTG 34213 Leu Gly Asp Arg Ala Ala Gly Ala Leu Ala Arg Gln Gly Ala Thr Val 980 985 990 GAA CGG CTG GTG GTC GAT CCG GTC GCC GTC GGA CGC GAC GGG CTC GCG 34261 Glu Arg Leu Val Val Asp Pro Val Ala Val Gly Arg Asp Gly Leu Ala 995 1000 1005 1010 GCG CGC CTG GGC GAA CGG TGG GAC GGT GTG CTG TCC CTG CTC GGC GCC 34309 Ala Arg Leu Gly Glu Arg Trp Asp Gly Val Leu Ser Leu Leu Gly Ala 1015 1020 1025 GAC GAG CGT CCG CTC CCA CGG CAT CCC GCC CTC AAC CGC GCC GTC ATG 34357 Asp Glu Arg Pro Leu Pro Arg His Pro Ala Leu Asn Arg Ala Val Met 1030 1035 1040 GGC ACC ACG CTG CTC GCC CAG GCC GCT CTG GAC GCA GGA TGC GAG GCG 34405 Gly Thr Thr Leu Leu Ala Gln Ala Ala Leu Asp Ala Gly Cys Glu Ala 1045 1050 1055 CGG ATA TGG GCC GTG ACG CGG GAG GCC GTC GCC GTC TCC CCG AGC GAG 34453 Arg Ile Trp Ala Val Thr Arg Glu Ala Val Ala Val Ser Pro Ser Glu 1060 1065 1070 GTG CCG CGG GAC GCC GGC GCG CAG CTC TGG GGG CTC GGG CGG GGC ATC 34501 Val Pro Arg Asp Ala Gly Ala Gln Leu Trp Gly Leu Gly Arg Gly Ile 1075 1080 1085 1090 GCG CTG GAA CAC CCC TCC CTC TGG GGC GGA TTG ATC GAT CTG CCC GCC 34549 Ala Leu Glu His Pro Ser Leu Trp Gly Gly Leu Ile Asp Leu Pro Ala 1095 1100 1105 GTG CCG GAC GAA CGC GCG TGG GCC AGG GCC GTC CGG CGG CTC GTC CCG 34597 Val Pro Asp Glu Arg Ala Trp Ala Arg Ala Val Arg Arg Leu Val Pro 1110 1115 1120 CAC GGT GAG GAC CAG ATC GCC GCG CGC GCC TCG GGT GCC TAT GGG CGC 34645 His Gly Glu Asp Gln Ile Ala Ala Arg Ala Ser Gly Ala Tyr Gly Arg 1125 1130 1135 AGG CTC CTG CCG GCT CCG CCG GCC GCG TCG CGC CGC ACC TGC ACA CCG 34693 Arg Leu Leu Pro Ala Pro Pro Ala Ala Ser Arg Arg Thr Cys Thr Pro 1140 1145 1150 TCC GGC ACG GTG CTG GTC ACC GGC GGT ACG GGA GCG CTC GGC GGT CAT 34741 Ser Gly Thr Val Leu Val Thr Gly Gly Thr Gly Ala Leu Gly Gly His 1155 1160 1165 1170 CTG GCC CGC CGT CTC GCA CGC GGC GGG ACC GGG CAT CTG GTG CTC ACC 34789 Leu Ala Arg Arg Leu Ala Arg Gly Gly Thr Gly His Leu Val Leu Thr 1175 1180 1185 AGC CGT CGC GGC CCG GAC GCG CCG GGC GCC GGT GAA CTC GCC GGT GAA 34837 Ser Arg Arg Gly Pro Asp Ala Pro Gly Ala Gly Glu Leu Ala Gly Glu 1190 1195 1200 CTC GCC TCC CTG GGC GCG AAG GTC ACG GTC GCC GCG TGC GAC ATG GCC 34885 Leu Ala Ser Leu Gly Ala Lys Val Thr Val Ala Ala Cys Asp Met Ala 1205 1210 1215 GAC CGT GAA GCC GTG CGG GCG CTG CTC GAC GAG CAC CGG CCG ACC GCG 34933 Asp Arg Glu Ala Val Arg Ala Leu Leu Asp Glu His Arg Pro Thr Ala 1220 1225 1230 GTG TTC CAC ACG GCG GGC ACG CCC CAC TCG GCG GAG TTC ACG GCG CTG 34981 Val Phe His Thr Ala Gly Thr Pro His Ser Ala Glu Phe Thr Ala Leu 1235 1240 1245 1250 GAC GAG ACG ACG ACG GCC GGG GTG TAC GGC GGG AAG GTC CTG GGT GCC 35029 Asp Glu Thr Thr Thr Ala Gly Val Tyr Gly Gly Lys Val Leu Gly Ala 1255 1260 1265 CGG CAT CTG GAC GAA CTG ACC CGG GAA CTC GGC ATC GGG CTG GAC GCG 35077 Arg His Leu Asp Glu Leu Thr Arg Glu Leu Gly Ile Gly Leu Asp Ala 1270 1275 1280 TTC GTC CTC TTC TCC TCC GGC GCC GCG GTC TGG GGC AGC GGC GGC CAG 35125 Phe Val Leu Phe Ser Ser Gly Ala Ala Val Trp Gly Ser Gly Gly Gln 1285 1290 1295 ACC GCT TAC GGG GCC GCG AAC GCC GCG CTG GAC GCC CTC GCC GAG CGG 35173 Thr Ala Tyr Gly Ala Ala Asn Ala Ala Leu Asp Ala Leu Ala Glu Arg 1300 1305 1310 CGC CGT GCC GCC GGG CTG CCC GCG ACC TCC GTC GCC TGG GGC CTG TGG 35221 Arg Arg Ala Ala Gly Leu Pro Ala Thr Ser Val Ala Trp Gly Leu Trp 1315 1320 1325 1330 GGC GGC GGA GGC ATG GGG GAG GGG GAC GGT GAG GAG TTC CTC AGC CGG 35269 Gly Gly Gly Gly Met Gly Glu Gly Asp Gly Glu Glu Phe Leu Ser Arg 1335 1340 1345 CGC GGC CTC GGC GTG ATG CCG CCG GAG GAC GCG CTG GAA GCC CTG GAC 35317 Arg Gly Leu Gly Val Met Pro Pro Glu Asp Ala Leu Glu Ala Leu Asp 1350 1355 1360 CGG GCC CTG GAC CGG GAG GAC ACC ACC GTC GTG GTG GCG GAT GTC GAC 35365 Arg Ala Leu Asp Arg Glu Asp Thr Thr Val Val Val Ala Asp Val Asp 1365 1370 1375 TGG GAG CGG TTC GCC CCG GCC TTC ACC GCG TTC CGG CCC AGT GCG CTG 35413 Trp Glu Arg Phe Ala Pro Ala Phe Thr Ala Phe Arg Pro Ser Ala Leu 1380 1385 1390 ATC TCC CGG CTG GTC TCG GAC GGC GGG GAG GCG GGG GGG CAG GAC GCC 35461 Ile Ser Arg Leu Val Ser Asp Gly Gly Glu Ala Gly Gly Gln Asp Ala 1395 1400 1405 1410 CCG GAC GGC ACG CTG TTC GCC GCC GGG TTC GCG GCC GCC GGG CCA CTG 35509 Pro Asp Gly Thr Leu Phe Ala Ala Gly Phe Ala Ala Ala Gly Pro Leu 1415 1420 1425 GAG CGG CAG GAG ATG CTG CTC GGC CTG GTG CGC CGG CAT GTG GCC GCC 35557 Glu Arg Gln Glu Met Leu Leu Gly Leu Val Arg Arg His Val Ala Ala 1430 1435 1440 GTA CTC GGC CAC CCG GGG ACC GCG GAC ATC GGT CCC GAC CGT GCT TTC 35605 Val Leu Gly His Pro Gly Thr Ala Asp Ile Gly Pro Asp Arg Ala Phe 1445 1450 1455 AAG GAG CTG GGG TTC AGT TCG GTC ACC GCC GTC GAG CTG GCC GGG CGG 35653 Lys Glu Leu Gly Phe Ser Ser Val Thr Ala Val Glu Leu Ala Gly Arg 1460 1465 1470 CTG GGC CGG GAG TGC GGA CGG AAG CTG CCG CCG ACG CTG GTC TTC GAC 35701 Leu Gly Arg Glu Cys Gly Arg Lys Leu Pro Pro Thr Leu Val Phe Asp 1475 1480 1485 1490 CAT CCG ACT GCC GCG GCG GCC GTC GAA CAC CTG GCG GAG CTG CTG ACA 35749 His Pro Thr Ala Ala Ala Ala Val Glu His Leu Ala Glu Leu Leu Thr 1495 1500 1505 CCG CCC GCC GGT CCC GCC GCC GGT CCC CGG GAG GAG GAG GCG CGG GCC 35797 Pro Pro Ala Gly Pro Ala Ala Gly Pro Arg Glu Glu Glu Ala Arg Ala 1510 1515 1520 GCC CTG GCG CGC GTG CCG CTC GAA CGG CTG AGG GAA GCC GGC CTG CTG 35845 Ala Leu Ala Arg Val Pro Leu Glu Arg Leu Arg Glu Ala Gly Leu Leu 1525 1530 1535 GAC GCA CTG CTG CGG CTC GCC GCG GAC GAA TCC GGG GCG ACA ACC CCC 35893 Asp Ala Leu Leu Arg Leu Ala Ala Asp Glu Ser Gly Ala Thr Thr Pro 1540 1545 1550 CGT ACG TCT GCC GCG TCC GGC GCA CCC CGC GGC CGG GAG GAG CCG GAC 35941 Arg Thr Ser Ala Ala Ser Gly Ala Pro Arg Gly Arg Glu Glu Pro Asp 1555 1560 1565 1570 GGC CGC GGC GAG CCG GAC GGC TCG GGA CAC CGC GAA AGC CCG GAC GCG 35989 Gly Arg Gly Glu Pro Asp Gly Ser Gly His Arg Glu Ser Pro Asp Ala 1575 1580 1585 GCC GGC GGG TCG GAC GCC CTG GAC GAT CTC GAC GGG GAC GCC CTG GTG 36037 Ala Gly Gly Ser Asp Ala Leu Asp Asp Leu Asp Gly Asp Ala Leu Val 1590 1595 1600 CGG CTC GCC CTC GGG GAA CCG GGC GAG TGA CCGGCCGGCG GAGCACACCC 36087 Arg Leu Ala Leu Gly Glu Pro Gly Glu * 1605 1610 GGCCGTCTCC GGCCCGGCCG CGGCCGGGCC GGAAGCCATC CGCCGCCCAC CCGGTACCG 36147 CCCCTCAAGC CCTTCAAGCC CTTCGACCCG TCCGATCAGT CAGTCCGGCG GTCCTCCACG 36207 ACCGGTCCGG AATCGCCCCC ACACGAGTCA GGAAGCACAC C ATG GCC ATG TCC 36260 Met Ala Met Ser 1 GCC GAG AGG CTG ACG GAG GCG CTG CGG ACC TCG CTC AAG GAG GCC GAG 36308 Ala Glu Arg Leu Thr Glu Ala Leu Arg Thr Ser Leu Lys Glu Ala Glu 5 10 15 20 CGG CTC CGG CGG CAG AAC CGC GAA CTG AGG GCC GCG CGG GAC GCG GCG 36356 Arg Leu Arg Arg Gln Asn Arg Glu Leu Arg Ala Ala Arg Asp Ala Ala 25 30 35 CGG GAG CCG ATC GCC GTC GTC GGC ATG GCC TGC CGC TAC CCG GGC GGT 36404 Arg Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg Tyr Pro Gly Gly 40 45 50 GTC ACC GGC CCC GAG GAG CTG TGG GAG CTG GTG GCC GGA GGC CGG GAC 36452 Val Thr Gly Pro Glu Glu Leu Trp Glu Leu Val Ala Gly Gly Arg Asp 55 60 65 GCG ATC GGG CCG TTC CCC GTG GAC CGG GGC TGG GAC GTG GCG TCG GTG 36500 Ala Ile Gly Pro Phe Pro Val Asp Arg Gly Trp Asp Val Ala Ser Val 70 75 80 TAC GAC CCG GAT CCC GAG TCG AAG GGC ACC ACG TAC TGC CGG GAG GGC 36548 Tyr Asp Pro Asp Pro Glu Ser Lys Gly Thr Thr Tyr Cys Arg Glu Gly 85 90 95 100 GGG TTC CTG GAA GGC GCC GGT GAC TTC GAC GCC GCC TTC TTC GGC ATC 36596 Gly Phe Leu Glu Gly Ala Gly Asp Phe Asp Ala Ala Phe Phe Gly Ile 105 110 115 TCG CCG CGC GAG GCC CTG GTG ATG GAC CCG CAG CAG CGG CTG CTG CTG 36644 Ser Pro Arg Glu Ala Leu Val Met Asp Pro Gln Gln Arg Leu Leu Leu 120 125 130 GAG GTG TCC TGG GAG GCG CTG GAA CGC GCG GGC ATC GAC CCG TCC TCG 36692 Glu Val Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Asp Pro Ser Ser 135 140 145 CTG CGC GGC AGC CGC GGT GGT GTC TAC GTG GGC GCC GCG CAC GGC TCG 36740 Leu Arg Gly Ser Arg Gly Gly Val Tyr Val Gly Ala Ala His Gly Ser 150 155 160 TAC GCC TCC GAT CCC CGG CTG GTG CCC GAG GGC TCG GAG GGC TAT CTG 36788 Tyr Ala Ser Asp Pro Arg Leu Val Pro Glu Gly Ser Glu Gly Tyr Leu 165 170 175 180 CTG ACC GGC AGC GCC GAC GCG GTG ATG TCC GGC CGC ATC TCC TAC GCG 46836 Leu Thr Gly Ser Ala Asp Ala Val Met Ser Gly Arg Ile Ser Tyr Ala 185 190 195 CTC GGT CTC GAA GGA CCG TCC ATG ACG GTG GAG ACG GCC TGC TCC TCC 36884 Leu Gly Leu Glu Gly Pro Ser Met Thr Val Glu Thr Ala Cys Ser Ser 200 205 210 TCG CTG GTG GCG CTG CAT CTG GCG GTA CGG GCG CTG CGG CAC GGC GAG 36932 Ser Leu Val Ala Leu His Leu Ala Val Arg Ala Leu Arg His Gly Glu 215 220 225 TGC GGG CTC GCG CTG GCG GGC GGG GTG GCG GTG ATG GCC GAT CCG GCG 36980 Cys Gly Leu Ala Leu Ala Gly Gly Val Ala Val Met Ala Asp Pro Ala 230 235 240 GCG TTC GTG GAG TTC TCC CGG CAG AAG GGG CTG GCC GCC GAC GGC CGC 37028 Ala Phe Val Glu Phe Ser Arg Gln Lys Gly Leu Ala Ala Asp Gly Arg 245 250 255 260 TGC AAG GCG TTC TCG GCC GCC GCC GAC GGC ACC GGC TGG GCC GAG GGC 37076 Cys Lys Ala Phe Ser Ala Ala Ala Asp Gly Thr Gly Trp Ala Glu Gly 265 270 275 GTC GGC GTG CTC GTC CTG GAG CGG CTG TCG GAC GCG CGC CGC GCG GGG 37124 Val Gly Val Leu Val Leu Glu Arg Leu Ser Asp Ala Arg Arg Ala Gly 280 285 290 CAC ACG GTC CTC GGC CTG GTC ACC GGC ACC GCG GTC AAC CAG GAC GGT 37172 His Thr Val Leu Gly Leu Val Thr Gly Thr Ala Val Asn Gln Asp Gly 295 300 305 GCC TCC AAC GGG CTG ACC GCG CCC AAC GGC CCA GCC CAG CAA CGC GTC 37220 Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ala Gln Gln Arg Val 310 315 320 ATC GCC GAG GCG CTC GCC GAC GCC GGG CTG TCC CCG GAG GAC GTG GAC 37268 Ile Ala Glu Ala Leu Ala Asp Ala Gly Leu Ser Pro Glu Asp Val Asp 325 330 335 340 GCG GTC GAG GCG CAC GGC ACC GGC ACC CGG CTC GGC GAC CCC ATC GAG 37316 Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu 345 350 355 GCC GGG GCG CTG CTC GCC GCC TCC GGA CGG AAC CGT TCC GGC GAC CAC 37364 Ala Gly Ala Leu Leu Ala Ala Ser Gly Arg Asn Arg Ser Gly Asp His 360 365 370 CCG CTG TGG CTC GGC TCG CTG AAG TCC AAC ATC GGG CAT GCC CAG GCC 37412 Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala 375 380 385 GCC GCC GGT GTC GGC GGC GTC ATC AAG ATG CTC CAG GCG CTG CGG CAC 37460 Ala Ala Gly Val Gly Gly Val Ile Lys Met Leu Gln Ala Leu Arg His 390 395 400 GGC TTG CTG CCC CGC ACC CTC CAC GCC GAC GAG CCG ACC CCG CAT GCC 37508 Gly Leu Leu Pro Arg Thr Leu His Ala Asp Glu Pro Thr Pro His Ala 405 410 415 420 GAC TGG AGC TCC GGC CGG GTA CGG CTG CTC ACC TCC GAG GTG CCG TGG 37556 Asp Trp Ser Ser Gly Arg Val Arg Leu Leu Thr Ser Glu Val Pro Trp 425 430 435 CAG CGG ACC GGC CGG CCC CGG CGG ACC GGG GTG TCC GCC TTC GGC GTC 37604 Gln Arg Thr Gly Arg Pro Arg Arg Thr Gly Val Ser Ala Phe Gly Val 440 445 450 GGC GGC ACC AAT GCC CAT GTC GTC CTC GAA GAG GCA CCC GCC CCG CCC 37652 Gly Gly Thr Asn Ala His Val Val Leu Glu Glu Ala Pro Ala Pro Pro 455 460 465 GCG CCG GAA CCG GCC GGG GAG GCC CCC GGC GGC TCC CGC GCC GCA GAA 37700 Ala Pro Glu Pro Ala Gly Glu Ala Pro Gly Gly Ser Arg Ala Ala Glu 470 475 480 GGG GCG GAA GGG CCC CTG GCC TGG GTG GTC TCC GGA CGC GAC GAG CCG 37748 Gly Ala Glu Gly Pro Leu Ala Trp Val Val Ser Gly Arg Asp Glu Pro 485 490 495 500 GCC CTG CGG TCC CAG GCC CGG CGG CTC CGC GAC CAC CTC TCC CGC ACC 37796 Ala Leu Arg Ser Gln Ala Arg Arg Leu Arg Asp His Leu Ser Arg Thr 505 510 515 CCC GGG GCC CGC CCG CGT GAC ATC GCC TTC TCC CTC GCC GCC ACG CGC 37844 Pro Gly Ala Arg Pro Arg Asp Ile Ala Phe Ser Leu Ala Ala Thr Arg 520 525 530 GCA GCC TTT GAC CAC CGC GCC GTG CTG ATC GGC TCG GAC GGG GCC GAA 37892 Ala Ala Phe Asp His Arg Ala Val Leu Ile Gly Ser Asp Gly Ala Glu 535 540 545 CTC GCC GCC GCC CTG GAC GCG TTG GCC GAA GGA CGC GAC GGT CCG GCG 37940 Leu Ala Ala Ala Leu Asp Ala Leu Ala Glu Gly Arg Asp Gly Pro Ala 550 555 560 GTG GTG CGC GGA GTC CGC GAC CGG GAC GGC AGG ATG GCC TTC CTC TTC 37988 Val Val Arg Gly Val Arg Asp Arg Asp Gly Arg Met Ala Phe Leu Phe 565 570 575 580 ACC GGG CAG GGC AGC CAG CGC GCC GGG ATG GCC CAC GAC CTG CAT GCC 38036 Thr Gly Gln Gly Ser Gln Arg Ala Gly Met Ala His Asp Leu His Ala 585 590 595 GCC CAT ACC TTC TTC GCG TCC GCC CTC GAC GAG GTG ACG GAC CGT CTC 38084 Ala His Thr Phe Phe Ala Ser Ala Leu Asp Glu Val Thr Asp Arg Leu 600 605 610 GAC CCG CTG CTC GGC CGG CCG CTC GGC GCG CTG CTG GAC GCC CGA CCC 38132 Asp Pro Leu Leu Gly Arg Pro Leu Gly Ala Leu Leu Asp Ala Arg Pro 615 620 625 GGC TCG CCC GAA GCG GCA CTC CTG GAC CGG ACC GAG TAC ACC CAG CCG 38180 Gly Ser Pro Glu Ala Ala Leu Leu Asp Arg Thr Glu Tyr Thr Gln Pro 630 635 640 GCG CTC TTC GCC GTC GAG GTG GCG CTC CAC CGG CTG CTG GAG CAC TGG 38228 Ala Leu Phe Ala Val Glu Val Ala Leu His Arg Leu Leu Glu His Trp 645 650 655 660 GGG ATG CGC CCC GAC CTG CTG CTG GGG CAC TCG GTG GGC GAA CTG GCG 38276 Gly Met Arg Pro Asp Leu Leu Leu Gly His Ser Val Gly Glu Leu Ala 665 670 675 GCC GCC CAC GTC GCG GGT GTG CTC GAT CTC GAC GAC GCC TGC GCG CTG 38324 Ala Ala His Val Ala Gly Val Leu Asp Leu Asp Asp Ala Cys Ala Leu 680 685 690 GTG GCC GCC CGC GGC AGG CTG ATG CAG CGC CTG CCG CCC GGC GGC GCG 38372 Val Ala Ala Arg Gly Arg Leu Met Gln Arg Leu Pro Pro Gly Gly Ala 695 700 705 ATG GTC TCC GTG CGG GCC GGC GAG GAC GAG GTC CGC GCA CTG CTG GCC 38420 Met Val Ser Val Arg Ala Gly Glu Asp Glu Val Arg Ala Leu Leu Ala 710 715 720 GGC CGC GAG GAC GCC GTC TGC GTC GCC GCG GTG AAC GGC CCC CGG TCG 38468 Gly Arg Glu Asp Ala Val Cys Val Ala Ala Val Asn Gly Pro Arg Ser 725 730 735 740 GTG GTG ATC TCC GGC GCG GAG GAA GCG GTG GCC GAG GCG GCG GCG CAG 38516 Val Val Ile Ser Gly Ala Glu Glu Ala Val Ala Glu Ala Ala Ala Gln 745 750 755 CTC GCC GGA CGA GGC CGC CGC ACC AGG CGG CTC CGC GTC GCG CAC GCC 38564 Leu Ala Gly Arg Gly Arg Arg Thr Arg Arg Leu Arg Val Ala His Ala 760 765 770 TTC CAC TCA CCC CTG ATG GAC GGC ATG CTC GCC GGA TTC CGG GAG GTC 38612 Phe His Ser Pro Leu Met Asp Gly Met Leu Ala Gly Phe Arg Glu Val 775 780 785 GCC GCC GGC CTG CGC TAC CGG GAA CCG GAG CTG ACG GTC GTC TCC ACG 38660 Ala Ala Gly Leu Arg Tyr Arg Glu Pro Glu Leu Thr Val Val Ser Thr 790 795 800 GTC ACG GGG CGG CCC GCC CGC CCC GGT GAA CTC ACC GGC CCC GAC TAC 38708 Val Thr Gly Arg Pro Ala Arg Pro Gly Glu Leu Thr Gly Pro Asp Tyr 805 810 815 820 TGG GTG GCC CAG GTC CGT GAG CCC GTG CGC TTC GCG GAC GCG GTC CGC 38756 Trp Val Ala Gln Val Arg Glu Pro Val Arg Phe Ala Asp Ala Val Arg 825 830 835 ACG GCA CAC CGC CTC GGA GCC CGC ACC TTC CTG GAG ACC GGC CCG GAC 38804 Thr Ala His Arg Leu Gly Ala Arg Thr Phe Leu Glu Thr Gly Pro Asp 840 845 850 GGC GTG CTG TGC GGC ATG GCA GAG GAG TGC CTG GAG GAC GAC ACC GTG 38852 Gly Val Leu Cys Gly Met Ala Glu Glu Cys Leu Glu Asp Asp Thr Val 855 860 865 GCC CTG CTG CCG GCG ATC CAC AAG CCC GGC ACC GCG CCG CAC GGT CCG 38900 Ala Leu Leu Pro Ala Ile His Lys Pro Gly Thr Ala Pro His Gly Pro 870 875 880 GCG GCT CCC GGC GCG CTG CGG GCG GCC GCC GCC GCG TAC GGC CGG GGC 38948 Ala Ala Pro Gly Ala Leu Arg Ala Ala Ala Ala Ala Tyr Gly Arg Gly 885 890 895 900 GCC CGG GTG GAC TGG GCC GGG ATG CAC GCC GAC GGC CCC GAG GGG CCG 38996 Ala Arg Val Asp Trp Ala Gly Met His Ala Asp Gly Pro Glu Gly Pro 905 910 915 GCC CGC CGC GTC GAA CTG CCC GTC CAC GCC TTC CGG CAC CGC CGC TAC 39044 Ala Arg Arg Val Glu Leu Pro Val His Ala Phe Arg His Arg Arg Tyr 920 925 930 TGG CTC GCC CCG GGC CGC GCG GCG GAC ACC GAC GAC TGG ATG TAC CGG 39092 Trp Leu Ala Pro Gly Arg Ala Ala Asp Thr Asp Asp Trp Met Tyr Arg 935 940 945 ATC GGC TGG GAC CGG CTG CCG GCT GTG ACC GGC GGG GCC CGG ACC GCC 39140 Ile Gly Trp Asp Arg Leu Pro Ala Val Thr Gly Gly Ala Arg Thr Ala 950 955 960 GGC CGC TGG CTG GTG ATC CAC CCC GAC AGC CCG CGC TGC CGG GAG CTG 39188 Gly Arg Trp Leu Val Ile His Pro Asp Ser Pro Arg Cys Arg Glu Leu 965 970 975 980 TCC GGC CAC GCC GAA CGC GCG CTG CGC GCC GCG GGC GCG AGC CCC GTA 39236 Ser Gly His Ala Glu Arg Ala Leu Arg Ala Ala Gly Ala Ser Pro Val 985 990 995 CCG CTG CCC GTG GAC GCT CCG GCC GCC GAC CGG GCG TCC TTC GCG GCA 39284 Pro Leu Pro Val Asp Ala Pro Ala Ala Asp Arg Ala Ser Phe Ala Ala 1000 1005 1010 CTG CTG CGC TCC GCC ACC GGA CCT GAC ACA CGA GGT GAC ACA GCC GCG 39332 Leu Leu Arg Ser Ala Thr Gly Pro Asp Thr Arg Gly Asp Thr Ala Ala 1015 1020 1025 CCC GTG GCC GGT GTG CTG TCG CTG CTG TCC GAG GAG GAT CGG CCC CAT 39380 Pro Val Ala Gly Val Leu Ser Leu Leu Ser Glu Glu Asp Arg Pro His 1030 1035 1040 CGC CAG CAC GCC CCG GTA CCC GCC GGG GTC CTG GCG ACG CTG TCC CTG 39428 Arg Gln His Ala Pro Val Pro Ala Gly Val Leu Ala Thr Leu Ser Leu 1045 1050 1055 1060 ATG CAG GCT ATG GAG GAG GAG GCG GTG GAG GCT CGC GTG TGG TGC GTC 39476 Met Gln Ala Met Glu Glu Glu Ala Val Glu Ala Arg Val Trp Cys Val 1065 1070 1075 TCC CGC GCC GCG GTC GCC GCC GCC GAC CGG GAA CGG CCC GTC GGC GCG 39524 Ser Arg Ala Ala Val Ala Ala Ala Asp Arg Glu Arg Pro Val Gly Ala 1080 1085 1090 GGC GCC GCC CTG TGG GGG CTG GGG CGG GTG GCC GCC CTG GAA CGC CCC 39572 Gly Ala Ala Leu Trp Gly Leu Gly Arg Val Ala Ala Leu Glu Arg Pro 1095 1100 1105 ACC CGG TGG GGC GGT CTC GTG GAC CTG CCC GCC TCG CCC GGT GCG GCG 39620 Thr Arg Trp Gly Gly Leu Val Asp Leu Pro Ala Ser Pro Gly Ala Ala 1110 1115 1120 CAC TGG GCG GCC GCC GTG GAA CGG CTC GCC GGT CCC GAG GAC CAG ATC 39668 His Trp Ala Ala Ala Val Glu Arg Leu Ala Gly Pro Glu Asp Gln Ile 1125 1130 1135 1140 GCC GTG CGC GCG TCC GGC AGT TGG GGC CGG CGC CTC ACC AGG CTG CCG 39716 Ala Val Arg Ala Ser Gly Ser Trp Gly Arg Arg Leu Thr Arg Leu Pro 1145 1150 1155 CGC GAC GGC GGC GGC CGG ACG GCC GCA CCC GCG TAC CGG CCG CGC GGC 39764 Arg Asp Gly Gly Gly Arg Thr Ala Ala Pro Ala Tyr Arg Pro Arg Gly 1160 1165 1170 ACG GTG CTC GTC ACC GGT GGC ACC GGC GCG CTC GGC GGG CAT CTC GCC 39812 Thr Val Leu Val Thr Gly Gly Thr Gly Ala Leu Gly Gly His Leu Ala 1175 1180 1185 CGC TGG CTC GCC GCG GCG GGC GCC GAA CAC CTG GCG CTC ACC AGC CGC 39860 Arg Trp Leu Ala Ala Ala Gly Ala Glu His Leu Ala Leu Thr Ser Arg 1190 1195 1200 CGG GGC CCG GAC GCG CCC GGC GCC GCC GGA CTC GAG GCC GAA CTC CTC 39908 Arg Gly Pro Asp Ala Pro Gly Ala Ala Gly Leu Glu Ala Glu Leu Leu 1205 1210 1215 1220 CTC CTG GGC GCC AAG GTG ACG TTC GCC GCC TGC GAC ACC GCC GAC CGC 39956 Leu Leu Gly Ala Lys Val Thr Phe Ala Ala Cys Asp Thr Ala Asp Arg 1225 1230 1235 GAC GGC CTC GCC CGG GTC CTG CGG GCG ATA CCG GAG GAC ACC CCG CTC 40004 Asp Gly Leu Ala Arg Val Leu Arg Ala Ile Pro Glu Asp Thr Pro Leu 1240 1245 1250 ACC GCG GTG TTC CAC GCC GCG GGC GTA CCG CAG GTC ACG CCG CTG TCC 40052 Thr Ala Val Phe His Ala Ala Gly Val Pro Gln Val Thr Pro Leu Ser 1255 1260 1265 CGT ACC TCG CCC GAG CAC TTC GCC GAC GTG TAC GCG GGC AAG GCG GCG 40100 Arg Thr Ser Pro Glu His Phe Ala Asp Val Tyr Ala Gly Lys Ala Ala 1270 1275 1280 GGC GCC GCG CAC CTG GAC GAA CTG ACC CGC GAA CTC GGC GCC GGA CTC 40148 Gly Ala Ala His Leu Asp Glu Leu Thr Arg Glu Leu Gly Ala Gly Leu 1285 1290 1295 1300 GAC GCG TTC GTC CTC TAC TCC TCC GGC GCC GGC GTC TGG GGC AGC GCC 40196 Asp Ala Phe Val Leu Tyr Ser Ser Gly Ala Gly Val Trp Gly Ser Ala 1305 1310 1315 GGC CAG GGT GCC TAC GCC GCC GCC AAC GCC GCC CTG GAC GCG CTC GCC 40244 Gly Gln Gly Ala Tyr Ala Ala Ala Asn Ala Ala Leu Asp Ala Leu Ala 1320 1325 1330 CGG CGC CGT GCG GCG GAC GGA CTC CCC GCC ACC TCC ATC GCC TGG GGC 40292 Arg Arg Arg Ala Ala Asp Gly Leu Pro Ala Thr Ser Ile Ala Trp Gly 1335 1340 1345 GTG TGG GGC GGC GGC GGT ATG GGG GCC GAC GAG GCG GGC GCG GAG TAT 40340 Val Trp Gly Gly Gly Gly Met Gly Ala Asp Glu Ala Gly Ala Glu Tyr 1350 1355 1360 CTG GGC CGG CGC GGT ATG CGC CCC ATG GCA CCG GTC TCC GCG CTC CGG 40388 Leu Gly Arg Arg Gly Met Arg Pro Met Ala Pro Val Ser Ala Leu Arg 1365 1370 1375 1380 GCG ATG GCC ACC GCC ATC GCC TCC GGG GAA CCC TGC CCC ACC GTC ACC 40436 Ala Met Ala Thr Ala Ile Ala Ser Gly Glu Pro Cys Pro Thr Val Thr 1385 1390 1395 CAC ACC GAC TGG GAG CGC TTC GGC GAG GGC TTC ACC GCC TTC CGG CCC 40484 His Thr Asp Trp Glu Arg Phe Gly Glu Gly Phe Thr Ala Phe Arg Pro 1400 1405 1410 AGC CCT CTG ATC GCG GGG CTC GGC ACG CCG GGC GGC GGC CGG GCG GCG 40532 Ser Pro Leu Ile Ala Gly Leu Gly Thr Pro Gly Gly Gly Arg Ala Ala 1415 1420 1425 GAG ACC CCC GAG GAG GGG AAC GCC ACC GCT GCG GCG GAC CTC ACC GCC 40580 Glu Thr Pro Glu Glu Gly Asn Ala Thr Ala Ala Ala Asp Leu Thr Ala 1430 1435 1440 CTG CCG CCC GCC GAA CTC CGC ACC GCG CTG CGC GAG CTG GTG CGA GCC 40628 Leu Pro Pro Ala Glu Leu Arg Thr Ala Leu Arg Glu Leu Val Arg Ala 1445 1450 1455 1460 CGG ACC GCC GCG GCG CTC GGC CTC GAC GAC CCG GCC GAG GTC GCC GAG 40676 Arg Thr Ala Ala Ala Leu Gly Leu Asp Asp Pro Ala Glu Val Ala Glu 1465 1470 1475 GGC GAA CGG TTC CCC GCC ATG GGC TTC GAC TCC CTG GCC ACC GTA CGG 40724 Gly Glu Arg Phe Pro Ala Met Gly Phe Asp Ser Leu Ala Thr Val Arg 1480 1485 1490 CTG CGC CGC GGA CTC GCC TCG GCC ACG GGC CTC GAC CTG CCC CCC GAT 40772 Leu Arg Arg Gly Leu Ala Ser Ala Thr Gly Leu Asp Leu Pro Pro Asp 1495 1500 1505 CTG CTC TTC GAC CGG GAC ACC CCG GCC GCG CTC GCC GCC CAC CTG GCC 40820 Leu Leu Phe Asp Arg Asp Thr Pro Ala Ala Leu Ala Ala His Leu Ala 1510 1515 1520 GAA CTG CTC GCC ACC GCA CGG GAC CAC GGA CCC GGC GGC CCC GGG ACC 40868 Glu Leu Leu Ala Thr Ala Arg Asp His Gly Pro Gly Gly Pro Gly Thr 1525 1530 1535 1540 GGT GCC GCG CCG GCC GAT GCC GGA AGC GGC CTG CCG GCC CTC TAC CGG 40916 Gly Ala Ala Pro Ala Asp Ala Gly Ser Gly Leu Pro Ala Leu Tyr Arg 1545 1550 1555 GAG GCC GTC CGC ACC GGC CGG GCC GCG GAA ATG GCC GAA CTG CTC GCC 40964 Glu Ala Val Arg Thr Gly Arg Ala Ala Glu Met Ala Glu Leu Leu Ala 1560 1565 1570 GCC GCT TCC CGG TTC CGC CCC GCC TTC GGG ACG GCG GAC CGG CAG CCG 41012 Ala Ala Ser Arg Phe Arg Pro Ala Phe Gly Thr Ala Asp Arg Gln Pro 1575 1580 1585 GTG GCC CTC GTG CCG CTG GCC GAC GGC GCG GAG GAC ACC GGG CTC CCG 41060 Val Ala Leu Val Pro Leu Ala Asp Gly Ala Glu Asp Thr Gly Leu Pro 1590 1595 1600 CTG CTC GTG GGC TGC GCC GGG ACG GCG GTG GCC TCC GGC CCG GTG GAG 41108 Leu Leu Val Gly Cys Ala Gly Thr Ala Val Ala Ser Gly Pro Val Glu 1605 1610 1615 1620 TTC ACC GCC TTC GCC GGA GCG CTG GCG GAC CTC CCG GCG GCG GCC CCG 41156 Phe Thr Ala Phe Ala Gly Ala Leu Ala Asp Leu Pro Ala Ala Ala Pro 1625 1630 1635 ATG GCC GCG CTG CCG CAG CCC GGC TTT CTG CCG GGA GAA CGA GTC CCG 41204 Met Ala Ala Leu Pro Gln Pro Gly Phe Leu Pro Gly Glu Arg Val Pro 1640 1645 1650 GCC ACC CCG GAG GCA TTG TTC GAG GCC CAG GCG GAA GCG CTG CTG CGC 41252 Ala Thr Pro Glu Ala Leu Phe Glu Ala Gln Ala Glu Ala Leu Leu Arg 1655 1660 1665 TAC GCG GCC GGC CGG CCC TTC GTG CTG CTG GGG CAC TCC GCC GGC GCC 41300 Tyr Ala Ala Gly Arg Pro Phe Val Leu Leu Gly His Ser Ala Gly Ala 1670 1675 1680 AAC ATG GCC CAC GCC CTG ACC CGT CAT CTG GAG GCG AAC GGT GGC GGC 41348 Asn Met Ala His Ala Leu Thr Arg His Leu Glu Ala Asn Gly Gly Gly 1685 1690 1695 1700 CCC GCA GGG CTG GTG CTC ATG GAC ATC TAC ACC CCC GCC GAC CCC GGC 41396 Pro Ala Gly Leu Val Leu Met Asp Ile Tyr Thr Pro Ala Asp Pro Gly 1705 1710 1715 GCG ATG GGC GTC TGG CGG AAC GAC ATG TTC CAG TGG GTC TGG CGG CGC 41444 Ala Met Gly Val Trp Arg Asn Asp Met Phe Gln Trp Val Trp Arg Arg 1720 1725 1730 TCG GAC ATC CCC CCG GAC GAC CAC CGC CTC ACG GCC ATG GGC GCC TAC 41492 Ser Asp Ile Pro Pro Asp Asp His Arg Leu Thr Ala Met Gly Ala Tyr 1735 1740 1745 CAC CGG CTG CTT CTC GAC TGG TCG CCC ACC CCC GTC CGC GCC CCC GTA 41540 His Arg Leu Leu Leu Asp Trp Ser Pro Thr Pro Val Arg Ala Pro Val 1750 1755 1760 CTG CAT CTG CGC GCC GCG GAA CCC ATG GGC GAC TGG CCA CCC GGG GAC 41588 Leu His Leu Arg Ala Ala Glu Pro Met Gly Asp Trp Pro Pro Gly Asp 1765 1770 1775 1780 ACC GGC TGG CAG TCC CAC TGG GAC GGC GCG CAC ACC ACC GCC GGC ATC 41636 Thr Gly Trp Gln Ser His Trp Asp Gly Ala His Thr Thr Ala Gly Ile 1785 1790 1795 CCC GGA AAC CAC TTC ACG ATG ATG ACC GAA CAC GCC TCC GCC GCC GCC 41684 Pro Gly Asn His Phe Thr Met Met Thr Glu His Ala Ser Ala Ala Ala 1800 1805 1810 CGG CTC GTG CAC GGC TGG CTC GCG GAA CGG ACC CCG TCC GGG CAG GGC 41732 Arg Leu Val His Gly Trp Leu Ala Glu Arg Thr Pro Ser Gly Gln Gly 1815 1820 1825 GGG TCA CCG TCC CGC GCG GCG GGG AGA GAG GAG AGG CCG TGA 41774 Gly Ser Pro Ser Arg Ala Ala Gly Arg Glu Glu Arg Pro * 1830 1835 1840 ACACGGCAGC CGGCCCGACC GGCACCGCCG CCGGCGGCAC CACCGCCCCG GCGGCGGCA 41834 ACGACCTGTC CCGCGCCGGA CGCAGGCTCC AACTCACCCG GGCCGCACAG TGGTTCGCCG 41894 GCAACCAGGG AGACCCCTAC GGGATGATCC TGCGCGCCGG CACCGCCGAC CCGGCACCGT 41954 ACGAGGAAGA GATCCGTGAG CGGGGGCCGC TGTTCCACAG CGAACTCCTC GGCGCCTGGG 42014 TGACCGGCAG CCGCCATGTC GCCGACGCCG TGACGGCCGA CGACGCGTTC GGCGCCCTCA 42074 CCGCGGACGG TGCACGGCCA GGAGTCCGCG AACTGCCGCT CTCCGGCAGC GCCCTCGACG 42134 CCGCCCACGG GAACCCCGGC GGCCCGCCCC TCCCCGGAGG GTGGCCGCAC CGGCCCCCGG 42194 ACAGGGAGGA GCGAGACGAC CCGGACCGGC ACGCGGCGGA CCTGCTGAAC GCCGCCGGCC 42254 CGGGGCAGGT CCTCGACCTC GTCCCGTTCG CCCGGCGGCT GGCGGCCCGG ACGGCCGGCG 42314 CGTGGCTGGG CGTCCCGGCG GAACGGCTGC CGCGCTTCGA GACGGCACTC ACCGGCTGCC 42374 GCCGCGCCCT CGACGCCCTG CTCTGCCCCC AGCTCCTGGC CGACGCGCGG GCCGGACTGG 42434 CCGCCGAGGA GGCCCTGCGC GCCGTGCTCG GCGAGACCCC GGAGGCACGC GGACGTCCGC 42494 CCGGCGCGGT CGAGGCGGCC CGCGCGCACG CCGTCAGCGC GGCGGAGCCC ATCGCCGTCC 42554 TGCTGTGCAA CGCGGTGCGG GAACTGATGG AACGGCCGGC CCAGTGGCGG GCGCTCACCG 42614 CCGACCCCGG CCTGGCGGGC GCCGCGATCA CCGAAACACT GCTCTGGGCA CCGCCGGTGC 42674 GCCTGGAGAG CAGGGTGGCA CGCGAGACGG CCGTACTCGC CGGGCGGACG CTGCCCGCTG 42734 GAACCCATCT CGTCGTCCTC GCCGCCGCCG CCAACCGCGA CGCCTGCCGG AACGCCGGTC 42794 CGGCCGTCAC CGGCTTCGAC GTCCTCCGCC GCGCCTCGGA CGGCGGCCCC CAGCCCCACG 42854 GACTCCCGGA GGACCTGCAC TTCCGTCTCT CGGGCCCGCT CGTCCGGCGG ACCGCCGAGG 42914 CCGGTCTGAG GGCGCTCGCC GAACGCTTCC CCGGCTGCGC CCGGCCGGCC CCGCAGTCCG 42974 AGTCCGCCGG TCACCGGTGC TCCGCGGTCT CGGCCGGCTG CCCGTCGCCC CGTATGTCCC 43034 CGAGTGAGAA GGGCACTGGA TGACCGCCGC CGAGGACCGC ACGGACCGGA AGGGAAACCG 43094 CCGATGCGCG TACTGCTGAC CTGTATCGCG CACAACACCC ACTACTACAA CCTGGTGCCG 43154 GTCGCCTGGG CCCTGAGAGC GGCCGGACAC GAGGTGCGGG TGGCCGCGCA GCCCGCCCTC 43214 ACCGACACGA TCACCGCCTC CGGACTGACC GCCGTGCCGG TCGGCGGCAA CGAGTCCGTG 43274 CTCGAG 43280

【００３６】配列番号：２配列の長さ：４４７３アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Ser Ser Ala Leu Arg Arg Ala Val Gln Ser Asn Cys Gly Tyr Gly 1 5 10 15 Asp Leu Met Thr Ser Asn Thr Ala Ala Gln Asn Thr Gly Asp Gln Glu 20 25 30 Asp Val Asp Gly Pro Asp Ser Thr His Gly Gly Glu Ile Ala Val Val 35 40 45 Gly Met Ser Cys Arg Leu Pro Gly Ala Ala Gly Val Glu Glu Phe Trp 50 55 60 Glu Leu Leu Arg Ser Gly Arg Gly Met Pro Thr Arg Gln Asp Asp Gly 65 70 75 80 Thr Trp Arg Ala Ala Leu Glu Asp His Ala Gly Phe Asp Ala Gly Phe 85 90 95 Phe Gly Met Asn Ala Arg Gln Ala Ala Ala Thr Asp Pro Gln His Arg 100 105 110 Leu Met Leu Glu Leu Gly Trp Glu Ala Leu Glu Asp Ala Gly Ile Val 115 120 125 Pro Gly Asp Leu Thr Gly Thr Asp Thr Gly Val Phe Ala Gly Val Ala 130 135 140 Ser Asp Asp Tyr Ala Val Leu Thr Arg Arg Ser Ala Val Ser Ala Gly 145 150 155 160 Gly Tyr Thr Ala Thr Gly Leu His Arg Ala Leu Ala Ala Asn Arg Leu 165 170 175 Ser His Phe Leu Gly Leu Arg Gly Pro Ser Leu Val Val Asp Ser Ala 180 185 190 Gln Ser Ala Ser Leu Val Ala Val Gln Leu Ala Cys Glu Ser Leu Arg 195 200 205 Arg Gly Glu Thr Ser Leu Ala Val Ala Gly Gly Val Asn Leu Ile Leu 210 215 220 Thr Glu Glu Ser Thr Thr Val Met Glu Arg Met Gly Ala Leu Ser Pro 225 230 235 240 Asp Gly Arg Cys His Thr Phe Asp Ala Arg Ala Asn Gly Tyr Val Arg 245 250 255 Gly Glu Gly Gly Gly Ala Val Val Leu Lys Pro Leu Asp Ala Ala Leu 260 265 270 Ala Asp Gly Asp Arg Val Tyr Cys Val Ile Lys Gly Gly Ala Val Asn 275 280 285 Asn Asp Gly Gly Gly Ala Ser Leu Thr Thr Pro Asp Arg Glu Ala Gln 290 295 300 Glu Ala Val Leu Arg Gln Ala Tyr Arg Arg Ala Gly Val Ser Thr Gly 305 310 315 320 Ala Val Arg Tyr Val Glu Leu His Gly Thr Gly Thr Arg Ala Gly Asp 325 330 335 Pro Val Glu Ala Ala Ala Leu Gly Ala Val Leu Gly Ala Gly Ala Asp 340 345 350 Ser Gly Arg Ser Thr Pro Leu Ala Val Gly Ser Val Lys Thr Asn Val 355 360 365 Gly His Leu Glu Gly Ala Ala Gly Ile Val Gly Leu Ile Lys Ala Thr 370 375 380 Leu Cys Val Arg Lys Gly Glu Leu Val Pro Ser Leu Asn Phe Ser Thr 385 390 395 400 Pro Asn Pro Asp Ile Pro Leu Asp Asp Leu Arg Leu Arg Val Gln Thr 405 410 415 Glu Arg Gln Glu Trp Asn Glu Glu Asp Asp Arg Pro Arg Val Ala Gly 420 425 430 Val Ser Ser Phe Gly Met Gly Gly Thr Asn Val His Leu Val Ile Ala 435 440 445 Glu Ala Pro Ala Ala Ala Gly Ser Ser Gly Ala Gly Gly Ser Gly Ala 450 455 460 Gly Ser Gly Ala Gly Ile Ser Ala Val Ser Gly Val Val Pro Val Val 465 470 475 480 Val Ser Gly Arg Ser Arg Val Val Val Arg Glu Ala Ala Gly Arg Leu 485 490 495 Ala Glu Val Val Glu Ala Gly Gly Val Gly Leu Ala Asp Val Ala Val 500 505 510 Thr Met Ala Asp Arg Ser Arg Phe Gly Tyr Arg Ala Val Val Leu Ala 515 520 525 Arg Gly Glu Ala Glu Leu Ala Gly Arg Leu Arg Ala Leu Ala Gly Gly 530 535 540 Asp Pro Asp Ala Gly Val Val Thr Gly Ala Val Leu Asp Gly Gly Val 545 550 555 560 Val Val Gly Ala Ala Pro Gly Gly Ala Gly Ala Ala Gly Gly Ala Gly 565 570 575 Ala Ala Gly Gly Ala Gly Gly Gly Gly Val Val Leu Val Phe Pro Gly 580 585 590 Gln Gly Thr Gln Trp Val Gly Met Gly Ala Gly Leu Leu Gly Ser Ser 595 600 605 Glu Val Phe Ala Ala Ser Met Arg Glu Cys Ala Arg Ala Leu Ser Val 610 615 620 His Val Gly Trp Asp Leu Leu Glu Val Val Ser Gly Gly Ala Gly Leu 625 630 635 640 Glu Arg Val Asp Val Val Gln Pro Val Thr Trp Ala Val Met Val Ser 645 650 655 Leu Ala Arg Tyr Trp Gln Ala Met Gly Val Asp Val Ala Ala Val Val 660 665 670 Gly His Ser Gln Gly Glu Ile Ala Ala Ala Thr Val Ala Gly Ala Leu 675 680 685 Ser Leu Glu Asp Ala Ala Ala Val Val Ala Leu Arg Ala Gly Leu Ile 690 695 700 Gly Arg Tyr Leu Ala Gly Arg Gly Ala Met Ala Ala Val Pro Leu Pro 705 710 715 720 Ala Gly Glu Val Glu Ala Gly Leu Ala Lys Trp Pro Gly Val Glu Val 725 730 735 Ala Ala Val Asn Gly Pro Ala Ser Thr Val Val Ser Gly Asp Arg Arg 740 745 750 Ala Val Ala Gly Tyr Val Ala Val Cys Gln Ala Glu Gly Val Gln Ala 755 760 765 Arg Leu Ile Pro Val Asp Tyr Ala Ser His Ser Arg His Val Glu Asp 770 775 780 Leu Lys Gly Glu Leu Glu Arg Val Leu Ser Gly Ile Arg Pro Arg Ser 785 790 795 800 Pro Arg Val Pro Val Cys Ser Thr Val Ala Gly Glu Gln Pro Gly Glu 805 810 815 Pro Val Phe Asp Ala Gly Tyr Trp Phe Arg Asn Leu Arg Asn Arg Val 820 825 830 Glu Phe Ser Ala Val Val Gly Gly Leu Leu Glu Glu Gly His Arg Arg 835 840 845 Phe Ile Glu Val Ser Ala His Pro Val Leu Val His Ala Ile Glu Gln 850 855 860 Thr Ala Glu Ala Ala Asp Arg Ser Val His Ala Thr Gly Thr Leu Arg 865 870 875 880 Arg Gln Asp Asp Ser Pro His Arg Leu Leu Thr Ser Thr Ala Glu Ala 885 890 895 Trp Ala His Gly Ala Thr Leu Thr Trp Asp Pro Ala Leu Pro Pro Gly 900 905 910 His Leu Thr Thr Leu Pro Thr Tyr Pro Phe Asn His His His Tyr Trp 915 920 925 Leu Asp Thr Ile Asp Gly Gly Gly Gly Asp Asp Ala Thr Gln Glu Lys 930 935 940 Glu Ser Gly Pro Leu Thr Arg Glu Leu Arg Gly Leu Pro Ser Ser Gln 945 950 955 960 Lys Gln Leu Gly Phe Leu Leu Asp Leu Val Cys Arg His Thr Ala Val 965 970 975 Val Leu Gly Leu Asp Thr Ala Ala Glu Val Asp Pro Asp Leu Ser Phe 980 985 990 Lys Lys Gln Gly Ile Gln Ser Met Thr Gly Val Glu Leu Arg Asn Arg 995 1000 1005 Leu Leu Thr Glu Thr Gly Leu Ala Leu Pro Thr Thr Leu Val Tyr Asp 1010 1015 1020 Arg Pro Thr Pro Arg Ala Leu Ala Gln Phe Leu His Thr Glu Leu Leu 1025 1030 1035 1040 Asp Gly Ser Pro Ser Gly Ser Val Leu Ala Pro Ala Gln Lys Ser Phe 1045 1050 1055 Glu Ala Gln Glu Pro Ile Ala Val Val Gly Met Gly Cys Arg Phe Pro 1060 1065 1070 Gly Gly Val Gly Ser Pro Glu Ala Leu Trp Arg Leu Val Val Glu Gly 1075 1080 1085 Val Asp Ala Val Ser Pro Phe Pro Gly Asp Arg Gly Trp Asp Val Glu 1090 1095 1100 Gly Leu Tyr Asp Pro Glu Pro Gly Val Ala Gly Lys Ser Tyr Val Arg 1105 1110 1115 1120 Glu Gly Gly Phe Leu His Asp Ala Ala Glu Phe Asp Ala Glu Phe Phe 1125 1130 1135 Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu 1140 1145 1150 Leu Leu Glu Thr Ser Trp Glu Ala Ile Glu Arg Ala Gly Ile Asp Pro 1155 1160 1165 His Ser Leu His Gly Ser Arg Thr Gly Val Tyr Ala Gly Val Met Pro 1170 1175 1180 Gln Glu Tyr Gly Pro Arg Leu Ala Glu Gly Ala Glu Gly Ser Asp Gly 1185 1190 1195 1200 Tyr Leu Leu Thr Gly Thr Ser Gly Ser Val Val Ser Gly Arg Val Ala 1205 1210 1215 Tyr Thr Leu Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys 1220 1225 1230 Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Gln Ala Leu Arg Gly 1235 1240 1245 Gly Glu Cys Asp Met Ala Leu Ala Gly Gly Val Thr Val Met Ala Gly 1250 1255 1260 Pro Gly Met Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp 1265 1270 1275 1280 Gly Arg Cys Lys Ala Phe Ala Asp Gly Ala Asp Gly Thr Ala Trp Ala 1285 1290 1295 Glu Gly Ala Gly Val Val Leu Val Glu Arg Leu Ser Asp Ala Arg Arg 1300 1305 1310 Leu Gly His Pro Val Leu Ala Val Val Cys Gly Ser Ala Val Asn Gln 1315 1320 1325 Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ser Gln Glu 1330 1335 1340 Arg Val Ile Arg Gln Ala Leu Gly Asn Ala Arg Leu Thr Val Ala Asp 1345 1350 1355 1360 Val Asp Val Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro 1365 1370 1375 Ile Glu Ala Gln Ala Leu Leu Gly Thr Tyr Gly Arg Asp Arg Asp Gly 1380 1385 1390 Gly Arg Pro Val Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala 1395 1400 1405 Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Leu Ala Met 1410 1415 1420 Arg Tyr Gly Trp Leu Pro Arg Thr Leu His Val Asp Glu Pro Ser Arg 1425 1430 1435 1440 His Val Asp Trp Ser Ala Gly Gly Val Trp Leu Leu Thr Glu Ala Arg 1445 1450 1455 Glu Trp Pro Gly Val Asp Arg Pro Arg Arg Ala Ala Val Ser Ala Phe 1460 1465 1470 Gly Val Ser Gly Thr Asn Ala His Leu Ile Leu Glu Ala Pro Asp Thr 1475 1480 1485 Ala Glu Ala Glu Ser Ala Thr Thr Pro Val Arg Ser Glu Val Ser Glu 1490 1495 1500 Ser Ala Ala Val Leu Asp Ala Arg Ser Gly Val Val Pro Val Val Val 1505 1510 1515 1520 Ser Gly Arg Ser Arg Val Val Val Arg Glu Ala Ala Gly Arg Leu Ala 1525 1530 1535 Glu Val Val Glu Ala Gly Gly Val Gly Leu Ala Asp Val Ala Val Thr 1540 1545 1550 Met Ala Gly Arg Ser Arg Phe Gly Tyr Arg Ala Val Val Leu Ala Arg 1555 1560 1565 Gly Glu Ala Glu Leu Ala Gly Arg Leu Arg Ala Leu Ala Gly Gly Asp 1570 1575 1580 Pro Asp Ala Gly Val Val Thr Gly Ala Val Val Asp Pro Glu Thr Gly 1585 1590 1595 1600 Ser Gly Gly Gly Gly Val Val Leu Val Phe Pro Gly Gln Gly Thr Gln 1605 1610 1615 Trp Val Gly Met Gly Ala Gly Leu Leu Gly Ser Ser Glu Val Phe Ala 1620 1625 1630 Ala Ser Met Arg Glu Cys Ala Arg Ala Leu Ser Val His Val Glu Trp 1635 1640 1645 Asp Leu Leu Glu Val Val Ser Gly Gly Ala Gly Leu Glu Arg Val Asp 1650 1655 1660 Val Val Gln Pro Val Thr Trp Ala Val Met Val Ser Leu Ala Arg Tyr 1665 1670 1675 1680 Trp Gln Ala Met Gly Val Asp Val Ala Ala Val Val Gly His Ser Gln 1685 1690 1695 Gly Glu Ile Ala Ala Ala Thr Val Ala Gly Ala Leu Ser Leu Glu Asp 1700 1705 1710 Ala Ala Ala Val Val Ala Leu Arg Ala Gly Leu Ile Gly Arg Tyr Leu 1715 1720 1725 Ala Gly Arg Gly Ala Met Ala Ala Val Pro Leu Pro Ala Gly Glu Val 1730 1735 1740 Glu Ala Gly Leu Ala Lys Trp Pro Gly Val Glu Val Ala Ala Val Asn 1745 1750 1755 1760 Gly Pro Ala Ser Thr Val Val Ser Gly Asp Arg Arg Ala Val Ala Gly 1765 1770 1775 Tyr Val Ala Val Cys Gln Ala Glu Gly Val Gln Ala Arg Leu Ile Pro 1780 1785 1790 Val Asp Tyr Ala Ser His Ser Arg His Val Glu Asp Leu Lys Gly Glu 1795 1800 1805 Leu Glu Arg Val Leu Ser Gly Ile Arg Pro Arg Ser Pro Arg Val Pro 1810 1815 1820 Val Cys Ser Thr Val Ala Gly Glu Gln Pro Gly Glu Pro Val Phe Asp 1825 1830 1835 1840 Ala Gly Tyr Trp Phe Arg Asn Leu Arg Asn Arg Val Glu Phe Ser Ala 1845 1850 1855 Val Val Gly Gly Leu Leu Glu Glu Gly His Arg Arg Phe Ile Glu Val 1860 1865 1870 Ser Ala His Pro Val Leu Val His Ala Ile Glu Gln Thr Ala Glu Ala 1875 1880 1885 Ala Asp Arg Ser Val His Ala Thr Gly Thr Leu Arg Arg Gln Asp Asp 1890 1895 1900 Ser Pro His Arg Leu Leu Thr Ser Thr Ala Glu Ala Trp Ala His Gly 1905 1910 1915 1920 Ala Thr Leu Thr Trp Asp Pro Ala Leu Pro Pro Gly His Leu Thr Thr 1925 1930 1935 Leu Pro Thr Tyr Pro Phe Asn His His His Tyr Trp Leu Asp Thr Thr 1940 1945 1950 Pro Thr Thr Pro Ala Thr Thr Thr Gln Ser Pro Thr Asp Ala Trp Arg 1955 1960 1965 Tyr Arg Val Thr Trp Lys Ala Leu Thr Glu Ser Ser Pro Val Arg Pro 1970 1975 1980 His Ser Ile Gly Arg Cys Leu Leu Val Ala Pro Pro Thr Thr Asp Gly 1985 1990 1995 2000 Glu Leu Leu Asp Gly Leu Thr Thr Val Leu Ser Glu Arg Gly Ala Ser 2005 2010 2015 Val Ala Arg Leu Glu Val Pro Ile Gly Ala Arg Arg Ala Glu Val Ala 2020 2025 2030 Glu Leu Leu Lys Pro Ser Met Glu Ser Ala Gly Glu Glu Asn Thr Thr 2035 2040 2045 Val Val Ser Leu Leu Gly Leu Val Pro Ser Thr Asp Ala Val Arg Thr 2050 2055 2060 Ser Ile Ala Leu Leu Gln Ala Val Ser Asp Ile Gly Val Pro Ala Ala 2065 2070 2075 2080 Arg Val Trp Ala Leu Thr Arg Arg Ala Val Ala Val Val Pro Gly Glu 2085 2090 2095 Thr Pro Gln Asp Ala Gly Ala Gln Leu Trp Gly Phe Gly Arg Val Ala 2100 2105 2110 Ala Leu Glu Leu Pro Asp Ile Trp Gly Gly Leu Ile Asp Leu Pro Glu 2115 2120 2125 Thr Ala Glu Leu Thr Arg Thr Pro Glu Thr Ser Gln Pro Pro Gln Thr 2130 2135 2140 Pro Glu Arg Leu Pro Gln Thr Pro Asn Arg Arg Ala Leu Glu Leu Ala 2145 2150 2155 2160 Ala Ala Val Leu Ala Gly Arg Asp Gly Glu Asp Gln Val Ala Val Arg 2165 2170 2175 Ala Ser Gly Ile Tyr Gly Arg Arg Val Ser Arg Ala Ala Ala Ala Gly 2180 2185 2190 Ala Ala Ser Trp Gln Pro Ser Gly Thr Val Leu Ile Thr Gly Gly Met 2195 2200 2205 Gly Ala Ile Gly Arg Arg Leu Ala Arg Arg Leu Ala Ala Glu Gly Ala 2210 2215 2220 Glu Arg Leu Val Leu Thr Ser Arg Arg Gly Pro Glu Ala Pro Gly Ala 2225 2230 2235 2240 Ala Glu Leu Ala Glu Glu Leu Arg Gly His Gly Cys Glu Val Val His 2245 2250 2255 Ala Ala Cys Asp Val Ala Glu Arg Asp Ala Leu Ala Ala Leu Val Thr 2260 2265 2270 Ala Tyr Pro Pro Asn Ala Val Phe His Thr Ala Gly Ile Leu Asp Asp 2275 2280 2285 Ala Val Ile Asp Thr Leu Ser Pro Glu Ser Phe Glu Thr Val Arg Gly 2290 2295 2300 Ala Lys Val Cys Gly Ala Glu Leu Leu His Gln Leu Thr Ala Asp Ile 2305 2310 2315 2320 Lys Gly Leu Asp Ala Phe Val Leu Phe Ser Ser Val Thr Gly Thr Trp 2325 2330 2335 Gly Asn Ala Gly Gln Gly Ala Tyr Ala Ala Ala Asn Ala Ala Leu Asp 2340 2345 2350 Ala Leu Ala Glu Arg Arg Arg Ala Ala Gly Leu Pro Ala Thr Ser Val 2355 2360 2365 Ala Trp Gly Leu Trp Gly Gly Gly Gly Met Ala Ala Gly Ala Gly Glu 2370 2375 2380 Glu Ser Leu Ser Arg Arg Gly Leu Arg Ala Met Asp Pro Asp Ala Ala 2385 2390 2395 2400 Val Asp Ala Leu Leu Gly Ala Met Gly Arg Asn Asp Val Cys Val Thr 2405 2410 2415 Val Val Asp Val Asp Trp Glu Arg Phe Ala Pro Ala Thr Asn Ala Ile 2420 2425 2430 Arg Pro Gly Arg Leu Phe Asp Thr Val Pro Glu Ala Arg Glu Ala Leu 2435 2440 2445 Thr Ala Ala Gly Thr Thr Ser Ala Thr Pro Asp Gly Ala Pro Glu Leu 2450 2455 2460 Ala Arg Arg Leu Ser Met Leu Asn Glu Thr Glu Arg Leu Arg Lys Leu 2465 2470 2475 2480 Val Glu Leu Val Arg Thr Glu Ala Ala Phe Val Leu Arg His Pro Asn 2485 2490 2495 Thr Asp Ala Ile Gly Ala Glu Arg Pro Phe Lys Ser Ala Gly Phe Asp 2500 2505 2510 Ser Leu Thr Ser Leu Glu Leu Arg Asn Arg Leu Asn Ala Gly Thr Gly 2515 2520 2525 Leu Lys Leu Pro Ala Thr Val Ile Phe Asp His Pro Ser Pro Thr Ala 2530 2535 2540 Leu Ala Arg Leu Leu Leu Asp Arg Leu Thr Gly Ala Gly Ala Pro Ala 2545 2550 2555 2560 Pro Ala Ala Asp Glu Pro Pro Leu Pro Val Ala Val Ala Asp Asp Asp 2565 2570 2575 Pro Val Val Ile Val Gly Met Ala Cys Arg Phe Pro Gly Gly Ala Gly 2580 2585 2590 Thr Pro Glu Ala Leu Trp Lys Leu Val Thr Glu Glu Arg Asp Val Ile 2595 2600 2605 Gly Ala Ala Pro Thr Asp Arg Gly Trp Asp Leu Asp Ser Val Tyr Asp 2610 2615 2620 Pro Glu Pro Gly Val Ala Gly Lys Thr Tyr Val Arg Glu Gly Gly Phe 2625 2630 2635 2640 Leu His Asp Ala Ala Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro 2645 2650 2655 Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr 2660 2665 2670 Ser Trp Glu Ala Ile Glu Arg Ala Gly Ile Asp Pro His Ser Leu His 2675 2680 2685 Gly Ser Arg Thr Gly Val Tyr Val Gly Leu Thr His Gln Glu Tyr Ala 2690 2695 2700 Ser Arg Leu His Glu Ala Pro Glu Glu Tyr Glu Gly Tyr Leu Leu Thr 2705 2710 2715 2720 Gly Lys Ser Ala Ser Val Val Ser Gly Arg Ile Ser Tyr Thr Leu Gly 2725 2730 2735 Leu Glu Gly Pro Ser Leu Ser Ile Asp Thr Ala Cys Ser Ser Ser Leu 2740 2745 2750 Val Ala Leu His Asn Ala Ala Gln Ala Leu Arg Gly Gly Glu Cys Asp 2755 2760 2765 Met Ala Leu Ala Gly Gly Val Thr Val Met Ala Ala Pro Gly Leu Phe 2770 2775 2780 Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys 2785 2790 2795 2800 Ala Phe Ala Asp Gly Ala Asp Gly Thr Ala Trp Ala Glu Gly Ala Gly 2805 2810 2815 Val Val Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Leu Gly His Pro 2820 2825 2830 Val Leu Ala Val Val Cys Gly Ser Ala Val Asn Gln Asp Gly Ala Ser 2835 2840 2845 Asn Gly Leu Thr Ala Pro Ser Gly Pro Ser Gln Glu Arg Val Ile Arg 2850 2855 2860 Gln Ala Leu Ala Asn Ala Arg Leu Thr Val Ala Asp Val Asp Val Val 2865 2870 2875 2880 Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln 2885 2890 2895 Ala Leu Leu Gly Thr Tyr Gly Arg Asp Arg Asp Ala Glu Cys Pro Val 2900 2905 2910 Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ala 2915 2920 2925 Gly Val Ala Gly Val Ile Lys Met Val Leu Ala Met Arg Tyr Gly Trp 2930 2935 2940 Leu Pro Arg Thr Leu His Val Asp Glu Pro Ser Arg His Val Asp Trp 2945 2950 2955 2960 Ser Ala Gly Gly Val Arg Leu Leu Thr Glu Ala Arg Glu Trp Pro Gly 2965 2970 2975 Val Asp Arg Pro Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser Gly 2980 2985 2990 Thr Asn Ala His Leu Ile Leu Glu Ala Pro Glu Ala Leu Glu Ala Leu 2995 3000 3005 Glu Ala Thr Asp Ala Pro Glu Ala Pro Glu Ala Pro Glu Ala Pro Asp 3010 3015 3020 Val Thr Asp Val Thr Glu Ala Leu Glu Ala Pro Asp Ala Thr Glu Ala 3025 3030 3035 3040 Glu Gly Ala Lys Ala Pro Gly Ser Pro Glu Glu Ala Gln Pro Ala Val 3045 3050 3055 Gly Val Val Pro Val Val Val Ser Gly Arg Ser Arg Val Val Val Arg 3060 3065 3070 Glu Ala Ala Gly Arg Leu Ala Glu Val Val Glu Ala Gly Gly Val Gly 3075 3080 3085 Leu Ala Asp Val Ala Val Thr Met Ala Gly Arg Ser Arg Phe Gly Tyr 3090 3095 3100 Arg Ala Val Val Leu Ala Arg Gly Glu Ala Glu Leu Ala Gly Arg Leu 3105 3110 3115 3120 Arg Ala Leu Ala Gly Gly Asp Pro Asp Ala Gly Val Val Thr Gly Ala 3125 3130 3135 Val Val Asp Pro Glu Thr Gly Ser Gly Gly Gly Gly Val Val Leu Val 3140 3145 3150 Phe Pro Gly Gln Gly Thr Gln Trp Val Gly Met Gly Ala Gly Leu Leu 3155 3160 3165 Gly Ser Ser Glu Val Phe Ala Ala Ser Met Arg Glu Cys Ala Arg Ala 3170 3175 3180 Leu Ser Val His Val Glu Trp Asp Leu Leu Glu Val Val Ser Gly Gly 3185 3190 3195 3200 Ala Gly Leu Glu Arg Val Asp Val Val Gln Pro Val Thr Trp Ala Val 3205 3210 3215 Met Val Ser Leu Ala Arg Tyr Trp Gln Ala Met Gly Val Asp Val Ala 3220 3225 3230 Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Thr Val Ala 3235 3240 3245 Gly Ala Leu Ser Leu Glu Asp Ala Ala Ala Val Val Ala Leu Arg Ala 3250 3255 3260 Gly Leu Ile Gly Arg Tyr Leu Ala Gly Arg Gly Ala Met Ala Ala Val 3265 3270 3275 3280 Pro Leu Pro Ala Gly Glu Val Glu Ala Gly Leu Ala Lys Trp Pro Gly 3285 3290 3295 Val Gln Val Ala Ala Val Asn Gly Pro Ala Ser Thr Val Val Ser Gly 3300 3305 3310 Asp Arg Arg Ala Val Ala Gly Tyr Val Ala Val Cys Gln Ala Glu Gly 3315 3320 3325 Val Gln Ala Arg Leu Ile Pro Val Asp Tyr Ala Ser His Ser Arg His 3330 3335 3340 Val Glu Asp Leu Lys Gly Glu Leu Glu Arg Val Leu Ser Gly Ile Arg 3345 3350 3355 3360 Pro Arg Ser Pro Arg Val Pro Val Cys Ser Thr Val Ala Gly Glu Gln 3365 3370 3375 Pro Gly Glu Pro Val Phe Asp Ala Gly Tyr Trp Phe Arg Asn Leu Arg 3380 3385 3390 Asn Arg Val Glu Phe Ser Ala Val Val Gly Gly Leu Leu Glu Gln Gly 3395 3400 3405 His Arg Arg Phe Ile Glu Val Ser Ala His Pro Val Leu Val His Ala 3410 3415 3420 Ile Glu Gln Thr Ala Glu Ala Ala Asp Arg Ser Val His Ala Thr Gly 3425 3430 3435 3440 Thr Leu Arg Arg Gln Asp Asp Ser Pro His Arg Leu Leu Thr Ser Thr 3445 3450 3455 Ala Glu Ala Trp Ala His Gly Ala Thr Leu Thr Trp Asp Pro Ala Leu 3460 3465 3470 Pro Pro Gly His Leu Thr Thr Leu Pro Thr Tyr Pro Phe Asn His His 3475 3480 3485 His Tyr Trp Ala Val Thr Ser Pro Ala Gly Val Gly Asp Ala Ala Ala 3490 3495 3500 Gly Arg Phe Gly Met Thr Trp Glu Asp His Pro Phe Leu Arg Gly Gly 3505 3510 3515 3520 Leu Pro Leu Ala Asp Ser Gly Glu Arg Val Phe Ala Gly Arg Leu Ala 3525 3530 3535 Gly Ser Glu His Asp Trp Leu Thr Asp His Ala Val Ser Gly Val Thr 3540 3545 3550 Leu Leu Pro Gly Thr Ala Phe Val Glu Phe Ala Leu His Ala Gly Ala 3555 3560 3565 Ala Thr Gly Cys Gly Arg Leu Glu Glu Leu Ser Val Glu Ala Pro Leu 3570 3575 3580 Val Leu Pro Ala Ala Gly Gly Val Arg Val Gln Met Arg Val Ser Ala 3585 3590 3595 3600 Ala Asp Glu Ser Gly Arg Arg Arg Val Ala Ile His Ser Ala Pro Glu 3605 3610 3615 Ala Ala Val His Ser Ala Ala Glu Gly Gly Asp Ser Ala Gly Val Trp 3620 3625 3630 Thr Arg His Gly Glu Gly Thr Leu Val Pro Asp Pro Glu Pro Thr Pro 3635 3640 3645 Pro Asp Ala Asp Trp Ala Arg Ala Trp Pro Pro Ala Gly Glu Arg Val 3650 3655 3660 Glu Pro Ala Glu Leu Tyr Glu Arg Phe Gly Ala Leu Gly Tyr Glu Tyr 3665 3670 3675 3680 Gly Glu Ala Phe Ala Gly Val Arg Ala Val Trp Arg Gln Pro Asp Ala 3685 3690 3695 Leu Leu Ala Glu Val Leu Leu Pro Asp Arg Ala Ser Thr Gly Ala Gly 3700 3705 3710 Arg Phe Gly Val His Pro Ala Leu Leu Asp Ala Ala Leu Gln Pro Trp 3715 3720 3725 Ile Ala Gly Gly Leu Leu Glu Val Pro Glu Asp Ala Val Leu Leu Pro 3730 3735 3740 Phe Ala Trp Gln Gly Val Ser Leu Tyr Ala Thr Gly Ala Gly Ala Leu 3745 3750 3755 3760 Arg Val Arg Leu Thr Lys Ala Gly Asp Gly Ala Val Ser Leu Gln Ala 3765 3770 3775 Ala Asp Thr Ser Gly Ala Ala Val Leu Ser Leu Gly Ala Leu Val Met 3780 3785 3790 Arg Pro Leu Ala Arg Arg Lys Leu Asp Val Leu Leu Gly Thr Asp Ala 3795 3800 3805 Gly Glu Arg Ser Leu Tyr Arg Val Glu Trp Gln Pro Arg Leu Leu Pro 3810 3815 3820 Ala Gly Pro Pro Arg Ser Trp Ala Val Leu Gly Pro Asp Ala Asp Arg 3825 3830 3835 3840 Leu Ala Gly Thr Pro Gly Leu Gly Asp Gln Pro Asp Gly Gly Pro Thr 3845 3850 3855 Ala Leu Tyr Pro Glu Val Arg Ala Leu Arg Lys Ala Leu Ala Ala Gly 3860 3865 3870 Ala Pro Arg Pro Glu Ala Val Val Leu Pro Val Leu Ser Gly Ala Gly 3875 3880 3885 Ala Thr Pro Glu Ser Val Arg Gln Thr Thr Glu Arg Cys Leu Thr Ala 3890 3895 3900 Leu Gln Asp Trp Leu Asp Ala Glu Glu Leu Val Asp Thr Pro Leu Ile 3905 3910 3915 3920 Val Leu Thr Arg Gly Ala Val Ala Ala Val Pro Gly Glu Glu Ile Gly 3925 3930 3935 Asp Leu Ala Cys Ala Gly Val Trp Gly Leu Val Arg Ser Ala Arg Ser 3940 3945 3950 Glu His Pro Gly Arg Phe Ala Leu Val Asp Thr Asp Gly His Pro Asp 3955 3960 3965 Asp Arg Thr Ala Leu Pro Leu Ala Leu Arg Ala Val Leu Asp Gly Ala 3970 3975 3980 Gly Gln Leu Ser Leu Arg Ala Gly Thr Ala Arg Thr Pro Val Leu Leu 3985 3990 3995 4000 Arg Ala Gly Thr Pro Glu Glu Gln Arg Gly Pro Ala Phe Asp Pro Ala 4005 4010 4015 Gly Thr Val Leu Val Thr Gly Ala Thr Gly Thr Leu Gly Arg Leu Leu 4020 4025 4030 Ala Arg His Leu Ala Ala Glu His Gly Val Arg His Leu Leu Leu Leu 4035 4040 4045 Ser Arg Gly Gly Arg Ala Ala Glu Gly Ala Asp Glu Leu Ala Ala Glu 4050 4055 4060 Leu Ala Gly Leu Glu Ala Glu Pro Cys Phe Ala Ala Cys Asp Ala Ala 4065 4070 4075 4080 Asp Arg Glu Ala Leu Ala Arg Val Leu Ala Glu Val Pro Ala Asp Arg 4085 4090 4095 Pro Leu Thr Gly Val Ile His Ala Ala Gly Val Leu Asp Asp Gly Thr 4100 4105 4110 Leu Asp Ala Leu Thr Pro Glu Arg Ile Gly Thr Val Met Arg Pro Lys 4115 4120 4125 Ala Asp Ala Ala Leu Asn Leu His Glu Leu Thr Arg Thr Ser Pro Leu 4130 4135 4140 Ser Val Phe Ala Val Phe Ser Gly Ala Ala Gly Ile Leu Gly Arg Pro 4145 4150 4155 4160 Gly Gln Ala Asn Tyr Ala Ala Ala Asn Thr Phe Leu Asp Ala Leu Ala 4165 4170 4175 Gln His Arg Arg Ala His Gly Leu Pro Ala Val Ser Leu Ala Trp Gly 4180 4185 4190 Leu Trp Gly Gly Ala Thr Gly Met Thr Gly His Leu Ser Gly Thr Asp 4195 4200 4205 Leu Arg Arg Met Arg Arg Ser Gly Ile Ala Pro Met Thr His Asp Gln 4210 4215 4220 Gly Leu Ala Leu Phe Asp Arg Ala Leu Ala Ala Ser Ala Glu Asp Pro 4225 4230 4235 4240 Leu Leu Val Pro Met Arg Leu Asp Leu Ala Ala Leu Val Arg Glu Arg 4245 4250 4255 Ala Glu His Gly Pro Asp Ala Val Pro Gly Pro Leu Leu Gly Leu Leu 4260 4265 4270 Pro Ala Arg Ala Ala Val Arg Gln Ala Ala Ala Pro Val Arg Gly Gly 4275 4280 4285 Ala Pro Ala Pro Ala Gly Gly Glu Gly Thr Ala Glu Arg Leu Ala Gly 4290 4295 4300 Leu Gly Glu Glu Ala Arg Leu Arg Glu Leu Val Arg Leu Val Arg Ala 4305 4310 4315 4320 Glu Val Ser Gly Val Leu Gly Tyr Ser Gly Pro Asp Ala Val Glu Pro 4325 4330 4335 Gly Arg Pro Phe Lys Asp Leu Gly Phe Asp Ser Leu Thr Ala Val Glu 4340 4345 4350 Leu Arg Asn Arg Leu Gly Ala Ala Thr Gly Leu Arg Leu Pro Thr Ala 4355 4360 4365 Leu Val Phe Asp Arg Pro Thr Ser Gln Ala Val Ala Glu Tyr Leu Ala 4370 4375 4380 Ala Glu Leu Ala Gly Pro Arg Asp Gly Gly Asp Thr Ala Ala Ala Ala 4385 4390 4395 4400 Phe Glu Gly Leu Glu Ala Leu Ala Ala Ala Val Gly Ala Leu Ala Glu 4405 4410 4415 Asp Asp Leu Arg Arg Asp Val Leu Arg Arg Arg Leu Thr Glu Leu Ala 4420 4425 4430 Ala Ala Leu Thr Pro Gln Gly Arg Asn Pro Ser Ala Pro Ala Pro Ala 4435 4440 4445 Pro Ser Asp Leu Asp Glu Arg Leu Asp Ser Ala Asn Asp Asp Asp Leu 4450 4455 4460 Phe Ala Phe Ile Glu Glu Gln Leu * 4465 4470

【００３７】配列番号：３配列の長さ：１８６５アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Thr Ala Glu Leu Val Ala Thr Arg Lys Arg Leu Gly Ala Leu Glu 1 5 10 15 Glu Arg Ala Arg Glu Pro Ile Ala Val Val Ala Met Ser Cys Arg Tyr 20 25 30 Pro Gly Gly Val Thr Thr Pro Glu Asp Leu Trp Arg Leu Leu Ala Asp 35 40 45 Glu Arg Asp Ala Val Ser Gly Leu Pro Arg Asp Arg Gly Trp Asp Leu 50 55 60 Asp Ala Leu Tyr Asp Pro Asp Gly Gly Pro Gly Thr Ser Tyr Ala Arg 65 70 75 80 Glu Gly Gly Phe Leu Ser His Cys Ala Gly Phe Asp Ala Glu Phe Phe 85 90 95 Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu 100 105 110 Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu Arg Ala Gly Val Thr Ala 115 120 125 Asp Arg Ala Arg Gly Ser Arg Thr Gly Val Tyr Ala Gly Val Met Tyr 130 135 140 Asp Asp Tyr Gly Ala Arg Val Leu Tyr Gly Ala Gly Ala Gly Pro Pro 145 150 155 160 Glu Asp Leu Glu Gly Tyr Leu Val Asn Gly Ser Ala Gly Ser Ile Ala 165 170 175 Ser Gly Arg Val Ser Tyr Thr Phe Gly Leu Arg Gly Pro Ala Val Thr 180 185 190 Val Asn Thr Ala Cys Ser Ser Ser Leu Val Ser Leu His Leu Ala Val 195 200 205 Arg Ala Leu Arg Asn Gly Glu Cys Asp Met Ala Leu Ala Gly Gly Ala 210 215 220 Thr Val Leu Ser Thr Pro Thr Val Leu Val Asp Phe Ser Arg Gln Arg 225 230 235 240 Gly Leu Ala Pro Asp Gly Arg Cys Lys Ala Phe Ala Asp Ser Ala Asp 245 250 255 Gly Thr Ser Trp Ala Glu Gly Ala Gly Met Leu Leu Leu Gln Arg Leu 260 265 270 Ser Asp Ala Arg Arg Glu Gly Arg Pro Val Leu Ala Val Ile Arg Gly 275 280 285 Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn 290 295 300 Gly Arg Ala Gln Arg Gln Val Ile Glu Asp Ala Leu Arg Asp Ala Gly 305 310 315 320 Val Gly Pro Asp Gln Val Asp Ala Val Glu Ala His Gly Thr Gly Thr 325 330 335 Glu Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu Leu Ala Thr Tyr Gly 340 345 350 Thr Ala Arg Thr Ala Glu Arg Pro Leu Trp Leu Gly Ser Leu Lys Ser 355 360 365 Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys 370 375 380 Met Val Leu Ala Met Arg His Gly Arg Leu Pro Arg Thr Leu His Val 385 390 395 400 Asp Arg Pro Thr Thr Arg Val Asp Trp Glu Lys Gly Gly Val Arg Leu 405 410 415 Leu Thr Glu Pro Val Pro Trp Pro Gly Glu Ala Gly Glu Pro Arg Arg 420 425 430 Ala Gly Val Ser Ser Phe Gly Ala Ser Gly Thr Asn Ala His Val Val 435 440 445 Leu Glu Ser Val Pro Ala Gly Glu Pro Pro Ala Ala Gly Arg Pro Glu 450 455 460 Asp Thr Gly Gly Ala Trp Thr Val Ser Gly Arg Gly Pro Ala Ala Leu 465 470 475 480 Arg Ala Gln Ala Ala Arg Leu Tyr Asp Ala Leu Thr Gly Thr Gly Thr 485 490 495 Gly Thr Gly Gln Gly Ala Gly Gln Gly Ala Gly Pro Gly Thr Ala Glu 500 505 510 Val Ala Gly Ala Leu Ala His Ala Arg Thr Ala Phe Arg His Arg Ala 515 520 525 Val Val Leu Gly Gly Asn Arg Ala Glu Leu Leu Ala Gly Leu Arg Glu 530 535 540 Leu Ala Glu Glu Glu His Pro Gly Pro Arg Val Val Thr Gly Thr Ala 545 550 555 560 Pro Ala Thr Glu Arg Arg Thr Ala Phe Leu Phe Ser Gly Gln Gly Ser 565 570 575 Gln Arg Ala Gly Ser Gly Arg Gly Leu Tyr Arg Arg His Pro Val Phe 580 585 590 Ala Arg Ala Leu Asp Glu Val Cys Ala Ala Leu Glu Pro His Leu His 595 600 605 Arg Pro Leu Arg Asp Leu Met Phe Ala Glu Pro Gly Ser Pro Glu Ala 610 615 620 Glu Pro Leu Asp Arg Thr Glu Phe Thr Gln Pro Ala Leu Phe Ala Leu 625 630 635 640 Gln Thr Ala Leu Phe Arg Leu Ala Glu His His Gly Leu Arg Ala Glu 645 650 655 Ala Leu Cys Gly His Ser Val Gly Glu Ile Ala Ala Ala His Ala Ala 660 665 670 Gly Val Leu Thr Leu Pro Asp Ala Ala Arg Leu Val Ala Ala Arg Gly 675 680 685 Arg Leu Met Gln Ala Leu Pro Ala Gly Gly Ala Met Ala Ala Leu Arg 690 695 700 Ala Thr Ala Glu Glu Ile Ala Pro Leu Leu Glu Arg Arg Ala Gly Glu 705 710 715 720 Leu Ala Leu Ala Ala Val Asn Gly Pro Ser Ser Val Val Val Ser Gly 725 730 735 Asp Glu Ala Ala Val Leu Glu Leu Leu Glu Gln Trp Arg Ala Glu Gly 740 745 750 Arg Glu Ala Arg Arg Leu Ala Val Ser His Ala Phe His Ser Pro Arg 755 760 765 Met Asp Gly Met Leu Thr Gln Phe Asp Arg Val Ala Arg Thr Leu Thr 770 775 780 Phe Ala Pro Pro Thr Ile Pro Leu Val Ser Thr Leu Thr Gly Thr Pro 785 790 795 800 Val Thr Glu Glu Thr Leu Cys Thr Ala Asp His Trp Val Arg Gln Ala 805 810 815 Arg Glu Pro Val Arg Phe Leu Asp Ala Met Arg Thr Leu Arg Ala Asp 820 825 830 Gly Ile Asp Thr Phe Val Glu Leu Gly Pro Asp Gly Val Leu Ser Ala 835 840 845 Met Ala Arg Asp Cys Ala Asp Asp Arg Pro Asp Gly Asp Thr Thr Gly 850 855 860 Ala Gly Asp Gly Glu Thr Pro Asp Pro Leu Leu Thr Leu Pro Leu Leu 865 870 875 880 Arg Arg Ser Val Pro Glu Thr Gly Asp Ala Glu His Pro Gly Gly Phe 885 890 895 Glu Arg Ala Leu Ala Thr Ala Tyr Ala His Gly Val Pro Leu Arg Leu 900 905 910 Ala Pro Ala Pro Asp Ala Ala Ser Leu Ala Val Ala Ala Glu Leu Pro 915 920 925 Thr Tyr Ala Phe Gln Arg Thr His Tyr Trp Leu Asp Ala Pro Ala Ala 930 935 940 Pro Ala Ala Leu Pro Ala Gly Leu Asp Asp Ala Gly His Pro Leu Leu 945 950 955 960 Ser Ala Ala Leu Asp Leu Pro Gly Gly Arg Gly Thr Val Trp Thr Gly 965 970 975 Ala Leu Ser Ala Ala Thr Leu Pro Trp Ala Ala Asp His Ser Val His 980 985 990 Gly Arg Thr Val Leu Pro Gly Thr Ala Leu Leu Asp Leu Ala Leu His 995 1000 1005 Ala Ala Pro Arg Val Gly Glu Leu Thr Phe Glu Ala Pro Leu Val Leu 1010 1015 1020 Pro Glu Asp Gly Glu Val Arg Leu Arg Val Val Leu Ala Glu Pro Asp 1025 1030 1035 1040 Ala Ser Gly Val Arg Glu Leu Ser Val His Ser Ala Gly Glu Asp Gly 1045 1050 1055 Gly Trp Thr Arg His Ala Thr Ala Val Leu Asp Thr Gly Thr Thr Thr 1060 1065 1070 Ala Gly Glu Pro Ala Gly Ala Pro Pro Ala Ala Trp Pro Pro Gly Asp 1075 1080 1085 Ala Glu Pro Leu Asp Leu Ala Ala Glu Tyr Glu Arg Phe Ala Asp Ala 1090 1095 1100 Gly Ile Gly Tyr Gly Pro Ala Phe Arg Gly Leu Arg Ser Ala Trp Arg 1105 1110 1115 1120 Asp Gly Asp Ala Ile Leu Ala Asp Val Arg Leu Pro Gly Glu Leu Ala 1125 1130 1135 Gly Glu Ala Asp Arg Tyr Gly Ile His Pro Ala Leu Leu Asp Ala Ala 1140 1145 1150 Leu His Thr Ala Ala Ala Ala Leu Gly Gly Ala His Gly Met Leu Pro 1155 1160 1165 Phe Thr Trp Asn Gly Val Thr Leu His Ala Arg Gly Ala His Ala Ile 1170 1175 1180 Arg Val Arg Leu Thr Pro Ala Gly Pro Asp Ala Val Ala Val Thr Ala 1185 1190 1195 1200 Val Asp Pro Ala Gly Arg Pro Val Phe Thr Ala Ala Ser Leu Thr Leu 1205 1210 1215 Arg Pro Val Thr Thr Gly Gln Leu Thr Ala Ala Glu Ala Ala Arg Ala 1220 1225 1230 Pro Leu Tyr Arg Val Arg Trp Thr Gly Leu Pro Asp Thr Gly Thr Ala 1235 1240 1245 Arg Asp His Thr Trp Ala Val Ala Gly Gly Pro Gly Asp Leu Leu Pro 1250 1255 1260 Gly Glu Thr Pro His His Pro Asp Leu Ala Ser Ala Leu Ala Asp Thr 1265 1270 1275 1280 Gly Thr Ala Pro Phe Arg Val Leu Ala Asp Leu Arg Gly Tyr Gly Thr 1285 1290 1295 Ala Thr Pro Arg Glu Leu Ala Ser Gln Ala Leu Ala Leu Val Gln Gln 1300 1305 1310 Trp Ala Asp Ala Ala Glu Ala Ala Glu Gly Arg Leu Val Leu Val Thr 1315 1320 1325 Arg Arg Ala Val Asp Ile Gly Asp Gly Val Thr Asp Pro Ala Ala Ala 1330 1335 1340 Thr Val Trp Gly Leu Val Arg Ala Ala Gln Ser Glu His Pro Gly Cys 1345 1350 1355 1360 Phe Ala Leu Leu Asp Thr Asp Asp Ser Pro Arg Ser Arg Gln Leu Leu 1365 1370 1375 Pro Arg Val Ala Gly Thr Ala Glu Gln Leu Ala Leu Arg Asp Gly Thr 1380 1385 1390 Leu Leu Ala Pro Ser Leu Thr Arg Ala Thr Leu Pro Ala Gly Ala Arg 1395 1400 1405 Leu Pro Ala Leu Asp Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Ser 1410 1415 1420 Leu Gly Ala Glu Ala Ala Arg His Leu Val Thr Arg His Gly Ala Arg 1425 1430 1435 1440 Arg Leu Leu Leu Thr Ser Arg Ser Gly Pro Gln Ala Pro Gly Ala Ala 1445 1450 1455 Glu Leu Val Ala Glu Leu Ala Ala Leu Gly Ala His Ala Asp Val Ala 1460 1465 1470 Ala Cys Asp Val Ala Asp Arg Ala Ala Leu Arg Ala Leu Leu Asp Arg 1475 1480 1485 Val Pro Ala Gly His Pro Leu Thr Ala Val Leu His Thr Ala Gly Val 1490 1495 1500 Leu Asp Asp Gly Val Leu Thr Ala Gln Thr Pro Gln Arg Leu Ala Ala 1505 1510 1515 1520 Val Leu Arg Pro Lys Ala Asp Ala Val Arg Asn Leu His Glu Leu Thr 1525 1530 1535 Gln Gly His Ala Leu Ser Ala Phe Ile Leu Tyr Ser Ser Ala Ala Gly 1540 1545 1550 Val Leu Gly Ser Ala Gly Gln Ser Gly Tyr Ala Ala Ala Asn Ala Tyr 1555 1560 1565 Leu Asp Ser Phe Ala Val Trp Arg Arg Ser Arg Gly Leu Pro Ala Val 1570 1575 1580 Ser Leu Gly Trp Gly Pro Trp Asp Gly Gly Gly Met Ala Ser Gly Leu 1585 1590 1595 1600 Gly Gly Thr Asp Thr Ala Arg Leu Arg Arg Ser Gly Ile Ala Pro Leu 1605 1610 1615 Ser Arg Ala Glu Gly Leu Ala Ala Leu Asp Ala Ala Leu Ala Ala Gly 1620 1625 1630 Gly Asp Asp Thr Ala Pro Ala His Leu Leu Pro Ile Arg Val Asp Ala 1635 1640 1645 Val Thr Leu Arg Gly Ala Asp Thr Val Pro Ala Val Leu Arg Asp Leu 1650 1655 1660 Ala Gly Thr Ala Pro Ser Ala Ala Glu Arg Pro Pro Gly Thr Pro Glu 1665 1670 1675 1680 Asp Thr Asn Ala Pro Leu Ala Asp Val Thr Gln Leu His Gly Arg Glu 1685 1690 1695 Arg Lys Glu Ala Leu Thr Gly Phe Val Arg Ala Gln Val Ala Ala Val 1700 1705 1710 Leu Gly His Pro Thr Ser Asp Thr Ile Asp Val Arg Arg Ser Phe Lys 1715 1720 1725 Glu Ala Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Arg Asn Arg Leu 1730 1735 1740 Arg Ala Ala Thr Gly Leu Lys Leu Pro Ala Thr Leu Val Phe Asp His 1745 1750 1755 1760 Pro Thr Pro Leu Ala Leu Ala Gly Phe Leu His Arg Glu Leu Pro Gly 1765 1770 1775 Ala Glu Ala Ser Leu Met Ser Ala Ile Asp Thr Leu Arg His Arg Leu 1780 1785 1790 Arg Asp Ala Leu Ala Asp Asp Ala Ala Asp Asp Ala Leu Arg Asp Gln 1795 1800 1805 Ile Thr Arg Arg Leu Glu Thr Leu Leu Ala Gly Ile Ala Arg Thr Glu 1810 1815 1820 Glu Pro Ala Pro Ala Thr Ala Ala Ala Asp Asp Gly Ser Gly Ala Gly 1825 1830 1835 1840 Asp Val Ala Glu Arg Leu Ser Thr Ala Ser Asp Asp Glu Leu Phe Glu 1845 1850 1855 Leu Leu Asp Ser Gly Phe Thr Pro * 1860 1865

【００３８】配列番号：４配列の長さ：３７３０アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Ser Thr Glu Asn Ser Thr Asn Val Pro Ala Ser Glu Asp Lys Leu 1 5 10 15 Arg Ala Tyr Leu Arg Arg Ala Met Ala Asp Leu His Glu Ser Arg Glu 20 25 30 Arg Leu Arg Ala Thr Glu Ala Arg Ala Gln Glu Pro Ile Ala Val Val 35 40 45 Gly Met Gly Cys Arg Phe Pro Gly Gly Val Gly Ser Pro Glu Ala Leu 50 55 60 Trp Arg Leu Val Val Glu Gly Val Asp Ala Val Ser Pro Phe Pro Gly 65 70 75 80 Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr Asp Pro Glu Pro Gly Val 85 90 95 Ala Gly Lys Ser Tyr Val Arg Glu Gly Gly Phe Leu His Asp Ala Ala 100 105 110 Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Val Ala 115 120 125 Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala Ile 130 135 140 Glu Arg Ala Gly Ile Asp Pro His Ser Leu His Gly Ser Arg Thr Gly 145 150 155 160 Val Tyr Ala Gly Val Met Tyr His Asp Tyr Gly Thr Gly Gln Thr Ser 165 170 175 Ala Thr Asp Thr Ser Gly Tyr Ser Gly Thr Gly Thr Ser Gly Ser Val 180 185 190 Val Ser Gly Arg Val Ala Tyr Thr Leu Gly Leu Glu Gly Pro Ala Val 195 200 205 Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala 210 215 220 Val Gln Ala Leu Arg Gly Gly Glu Cys Asp Met Ala Leu Ala Gly Gly 225 230 235 240 Val Thr Val Met Ala Gly Pro Gly Met Phe Val Glu Phe Ser Arg Gln 245 250 255 Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Asp Gly Ala 260 265 270 Asp Gly Thr Ala Trp Ala Glu Gly Ala Gly Val Val Leu Val Glu Arg 275 280 285 Leu Ser Asp Ala Arg Arg Leu Gly His Pro Val Leu Ala Val Val Cys 290 295 300 Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 305 310 315 320 Ser Gly Pro Ser Gln Glu Arg Val Ile Arg Gln Ala Leu Ala Asn Ala 325 330 335 Arg Leu Thr Val Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 340 345 350 Thr Arg Leu Gly Asp Pro Ile Glu Ala Gln Ala Leu Leu Gly Thr Tyr 355 360 365 Gly Arg Asp Arg Asp Gly Gly Arg Pro Val Trp Leu Gly Ser Leu Lys 370 375 380 Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Ala Gly Val Ile 385 390 395 400 Lys Met Val Leu Ala Met Arg Tyr Gly Trp Leu Pro Arg Thr Leu His 405 410 415 Val Asp Glu Pro Ser Arg His Val Asp Trp Ser Ala Gly Gly Val Trp 420 425 430 Leu Leu Thr Glu Ala Arg Glu Trp Pro Gly Val Asp Arg Pro Arg Arg 435 440 445 Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Leu Ile 450 455 460 Leu Glu Ala Pro Asp Thr Ala Glu Ala Glu Ser Ala Thr Thr Pro Val 465 470 475 480 Arg Ser Glu Val Ser Glu Ser Ala Ala Val Phe Asp Ala Arg Ser Gly 485 490 495 Val Val Pro Val Val Val Ser Gly Arg Ser Arg Val Val Val Arg Glu 500 505 510 Ala Ala Gly Arg Leu Ala Glu Val Val Glu Ala Gly Gly Val Gly Leu 515 520 525 Ala Asp Val Ala Val Thr Met Ala Gly Arg Ser Arg Phe Gly Tyr Arg 530 535 540 Ala Val Val Leu Ala Arg Gly Glu Ala Glu Leu Ala Gly Arg Leu Arg 545 550 555 560 Ala Leu Ala Gly Gly Asp Pro Asp Ala Gly Val Val Thr Gly Ala Val 565 570 575 Val Asp Pro Glu Thr Gly Ser Gly Gly Gly Gly Val Val Leu Val Phe 580 585 590 Pro Gly Gln Gly Thr Gln Trp Val Gly Met Gly Ala Gly Leu Leu Gly 595 600 605 Ser Ser Glu Val Phe Ala Ala Ser Met Arg Glu Cys Ala Arg Ala Leu 610 615 620 Ser Val His Val Gly Trp Asp Leu Leu Glu Val Val Ser Gly Gly Ala 625 630 635 640 Gly Leu Glu Arg Val Asp Val Val Gln Pro Val Thr Trp Ala Val Met 645 650 655 Val Ser Leu Ala Arg Tyr Trp Gln Ala Met Gly Val Asp Val Ala Ala 660 665 670 Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Thr Val Ala Gly 675 680 685 Ala Leu Ser Leu Glu Asp Ala Ala Ala Val Val Ala Leu Arg Ala Gly 690 695 700 Leu Ile Gly Arg Tyr Leu Ala Gly Arg Gly Ala Met Ala Ala Val Pro 705 710 715 720 Leu Pro Ala Gly Glu Val Glu Ala Gly Leu Ala Lys Trp Pro Gly Val 725 730 735 Glu Val Ala Ala Val Asn Gly Pro Ala Ser Thr Val Val Ser Gly Asp 740 745 750 Arg Arg Ala Val Ala Gly Tyr Val Ala Val Cys Gln Ala Glu Gly Val 755 760 765 Gln Ala Arg Leu Ile Pro Val Asp Tyr Ala Ser His Ser Arg His Val 770 775 780 Glu Asp Leu Lys Gly Glu Leu Glu Arg Val Leu Ser Gly Ile Arg Pro 785 790 795 800 Arg Ser Pro Arg Val Pro Val Cys Ser Thr Val Ala Gly Glu Gln Pro 805 810 815 Gly Glu Pro Val Phe Asp Ala Gly Tyr Trp Phe Arg Asn Leu Arg Asn 820 825 830 Arg Val Glu Phe Ser Ala Val Val Gly Gly Leu Leu Glu Glu Gly His 835 840 845 Arg Arg Phe Ile Glu Val Ser Ala His Pro Val Leu Val His Ala Ile 850 855 860 Glu Gln Thr Ala Glu Ala Ala Asp Arg Ser Val His Ala Thr Gly Thr 865 870 875 880 Leu Arg Arg Gln Asp Asp Ser Pro His Arg Leu Leu Thr Ser Thr Ala 885 890 895 Glu Ala Trp Ala His Gly Ala Thr Leu Thr Trp Asp Pro Ala Leu Pro 900 905 910 Pro Gly His Leu Thr Thr Leu Pro Thr Tyr Pro Phe Asn His His His 915 920 925 Tyr Trp Leu Asp Thr Thr Pro Thr Thr Pro Ala Thr Thr Thr Gln Ser 930 935 940 Pro Thr Asp Ala Gln Asn Pro Ala Asp Ala Leu Pro Tyr Lys Val Ser 945 950 955 960 Trp Lys Arg Leu Arg Asp Gln Asp Ser Leu Thr Ala Arg Leu Asp Gly 965 970 975 Arg Trp Leu Leu Val Val Pro Glu Ala Ser Ala Asp Pro Ser Val Ala 980 985 990 Glu Gly Val Ala Arg Glu Leu Thr Ala Arg Gly Ala Thr Val Glu Ser 995 1000 1005 Leu Thr Val Glu Pro Gly Ala Asp Arg Ser Arg Leu Arg Gly Leu Leu 1010 1015 1020 Val Asp Ala Thr Glu Arg Asp Glu Ala Gly Pro Leu Arg Gly Ile Val 1025 1030 1035 1040 Ser Leu Leu Ala Leu Ala Gly Asp His Ala Gly Ala Asp Gly Ala Arg 1045 1050 1055 Pro Val Val Pro Ala Gly Leu Ala Ala Ser Leu Ala Leu Ile Gln Ala 1060 1065 1070 Ala Gly Asp Ala Gly Thr Glu Ala Gly Leu Trp Ala Val Thr Arg Gly 1075 1080 1085 Ala Val Ala Ala Val Pro Gly Asp Val Pro Ala Pro Ser Gln Ala Leu 1090 1095 1100 Leu Trp Gly Phe Gly Arg Val Ala Gly Ile Glu Leu Pro His Cys Trp 1105 1110 1115 1120 Gly Gly Leu Leu Asp Leu Pro Thr Gly Pro Gly Asp Ser Gly Phe Arg 1125 1130 1135 Gln Leu Ala Ala Thr Leu Ala Gly Arg Pro Ala Glu Asp Gln Val Ala 1140 1145 1150 Leu Arg Ala Ser Gly Ala Tyr Gly Arg Arg Leu Val Arg Ala Ser Ala 1155 1160 1165 Ala Gly Gly Ala Asp Gly Trp Arg Pro Arg Gly Thr Val Leu Val Val 1170 1175 1180 Gly Asp Thr Ala Glu Val Ala Gly Pro Leu Val Arg Trp Leu Leu Gly 1185 1190 1195 1200 Asn Gly Ala Arg Arg Val Thr Leu Ser Gly Leu Ser Gly Pro Leu Pro 1205 1210 1215 Glu Glu Leu Ala Asp Val Ala Ala Arg Val Thr Val Ala Pro Cys Asp 1220 1225 1230 Pro Ala Asp Arg Pro Ala Leu Arg Thr Leu Leu Ala Glu Gln Ala Pro 1235 1240 1245 Thr Ala Val Leu Val Ala Pro Pro Ala Val Pro Pro Thr Pro Leu Ala 1250 1255 1260 Glu Met Thr Ala Glu Ala Leu Ala Ile Ala Leu Ser Ala Lys Thr Gly 1265 1270 1275 1280 Leu Val Asp Arg Leu Asp Ser Leu Leu Asp Glu Pro Asp Pro Leu Leu 1285 1290 1295 Glu Asp Gly Glu Leu Asp Ala Phe Val Val Phe Ser Ser Val Ala Gly 1300 1305 1310 Val Trp Gly Gly Ala Gly Gln Gly Gly Tyr Ala Ala Gly Thr Ala Tyr 1315 1320 1325 Leu Asp Ala Leu Ala Glu Cys Arg Arg Ala Gly Gly Leu Pro Val Thr 1330 1335 1340 Ser Val Ala Trp Thr Pro Trp Leu Gly Thr Pro Ala Ala Asp Ser Leu 1345 1350 1355 1360 Gly Glu Gln Met Ser Arg Ala Gly Ile Thr Pro Leu Asp Pro Ala Ala 1365 1370 1375 Ser Leu Asp Ala Leu Ala Arg Ala Val Gly Arg Arg Ala Gly Cys Val 1380 1385 1390 Thr Val Ala Asp Ile Asp Trp Glu Arg Phe Ala Ser Ala Tyr Thr Ala 1395 1400 1405 Thr Arg Pro Thr Pro Met Phe Asp Glu Val Pro Glu Val Arg Arg Ile 1410 1415 1420 Gln Ala Ala Trp Ala Glu Ala Glu Ala Asp Ala Ala Arg Ser Gly Ala 1425 1430 1435 1440 Gly Gly Asp Ser Gln Leu Leu Arg Ser Leu Arg Gly Arg Pro Glu Glu 1445 1450 1455 Ala Gln Leu Ala Glu Leu Leu Arg Leu Val Arg Thr His Ala Ala Ala 1460 1465 1470 Val Leu Gly Leu Gly Ser Pro Gly Ala Val Glu Ala Arg Arg Ser Phe 1475 1480 1485 Lys Asp Leu Gly Phe Asn Ser Val Thr Ala Val Glu Leu Arg Asn Arg 1490 1495 1500 Leu Lys Glu Ala Thr Gly Leu Arg Leu Glu Val Ser Leu Val Phe Asp 1505 1510 1515 1520 His Pro Asp Pro Ala Ser Leu Ala Arg His Leu Leu Asp Leu Ala Leu 1525 1530 1535 Gly Gln Glu Pro Glu Glu Thr Pro Arg Ala Phe Ala Leu Glu Pro Ala 1540 1545 1550 Pro Asn Gly Glu Pro Ile Ala Ile Val Ser Met Ala Cys Arg Met Pro 1555 1560 1565 Gly Gly Val Ser Thr Pro Glu Glu Leu Trp Arg Leu Leu Arg Asp Gly 1570 1575 1580 Lys Asp Ala Ile Gly Pro Phe Pro Ala Asn Arg Gly Trp Asp Leu Glu 1585 1590 1595 1600 Asn Leu Tyr Asp Pro Asp Pro Asp Ala Asp Gly Arg Thr Tyr Val Arg 1605 1610 1615 Glu Gly Gly Phe Leu His Glu Ala Pro Asp Phe Asp Pro Ser Phe Phe 1620 1625 1630 Gly Ile Ser Pro Arg Glu Ala Leu Ala Met Asp Pro Gln Gln Arg Leu 1635 1640 1645 Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Asp Pro 1650 1655 1660 Ala Arg Leu Arg Gly Ser Arg Thr Gly Val Phe Val Gly Thr Asn Gly 1665 1670 1675 1680 Gln His Tyr Met Pro Leu Leu Gln Asn Gly Gly Asp Ser Phe Asp Gly 1685 1690 1695 Tyr Leu Gly Thr Gly Asn Ser Ala Ser Val Met Ser Gly Arg Leu Ser 1700 1705 1710 Tyr Val Phe Gly Leu Glu Gly Pro Ala Val Thr Val Asp Thr Ala Cys 1715 1720 1725 Ser Ala Ser Leu Val Ala Leu His Leu Ala Val Gln Ala Met Arg Arg 1730 1735 1740 Gly Glu Cys Asp Met Ala Leu Val Gly Gly Ala Thr Val Met Ser Thr 1745 1750 1755 1760 Pro Glu Met Leu Val Glu Phe Ser Arg Gln Arg Val Ile Ser Ala Asn 1765 1770 1775 Gly Arg Ser Arg Ala Phe Ala Ala Gly Ala Asp Gly Val Ala Leu Gly 1780 1785 1790 Glu Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Glu Arg 1795 1800 1805 Asn Gly His Pro Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln 1810 1815 1820 Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ser Gln Gln 1825 1830 1835 1840 Arg Val Ile Arg Gln Ala Leu Ala Asp Ala Gly Leu Arg Pro Glu Asp 1845 1850 1855 Ile Asp Ala Val Glu Ala His Gly Thr Gly Thr Glu Leu Gly Asp Pro 1860 1865 1870 Ile Glu Ala Glu Ala Leu Leu Ala Thr Tyr Gly Arg Thr Arg Thr Ala 1875 1880 1885 Asp Arg Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr 1890 1895 1900 Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Leu Ala Leu 1905 1910 1915 1920 Gly Asn Glu Thr Leu Pro Arg Thr Leu His Val Asp Glu Pro Thr Pro 1925 1930 1935 Arg Val Asp Trp Ser Ser Gly Ala Val Ser Leu Leu Thr Glu Pro Val 1940 1945 1950 Asp Trp Pro Ala Gly Pro Ser Ala Pro Arg Arg Ala Ala Val Ser Ser 1955 1960 1965 Phe Gly Ile Ser Gly Thr Asn Ala His Thr Ile Leu Glu Gln Ala Pro 1970 1975 1980 Val Pro Ala Glu Ser Arg Pro Gly Thr Glu Pro Ala Asp Gly Thr Gly 1985 1990 1995 2000 Ala Trp Glu Asn Val Thr Val Pro Leu Leu Leu Ser Gly His Thr Glu 2005 2010 2015 Ala Ala Leu Arg Glu Gln Ser Thr Arg Leu Leu Asn Asp Leu Leu Glu 2020 2025 2030 His Pro Asp Glu His Pro Ala Asp Val Gly Tyr Thr Leu Ile Thr Gly 2035 2040 2045 Arg Ala His Phe Gly His Arg Ala Ala Val Ile Gly Glu Ser Arg Glu 2050 2055 2060 Glu Leu Leu Asp Ala Leu Lys Ala Leu Ala Glu Gly Arg Glu His His 2065 2070 2075 2080 Thr Val Val Arg Gly Asp Gly Thr Ala His Pro Asp Arg Arg Val Val 2085 2090 2095 Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Pro Ser Met Ala Arg Asp 2100 2105 2110 Leu Leu Asp Arg Ala Pro Ala Phe Arg Glu Thr Ala Lys Ala Cys Asp 2115 2120 2125 Ala Ala Leu Ser Val His Leu Asp Trp Ser Val Leu Asp Val Leu Gln 2130 2135 2140 Glu Lys Pro Asp Ala Pro Pro Leu Ser Arg Val Asp Val Val Gln Pro 2145 2150 2155 2160 Val Leu Phe Thr Met Met Leu Ser Leu Ala Ala Cys Trp Arg Asp Leu 2165 2170 2175 Gly Val His Pro Ala Ala Val Val Gly His Ser Gln Gly Glu Ile Ala 2180 2185 2190 Ala Ala Cys Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg Ile 2195 2200 2205 Val Ala Leu Arg Ser Arg Ala Trp Leu Thr Leu Ala Gly Lys Gly Gly 2210 2215 2220 Met Ala Ala Val Ser Leu Pro Glu Ala Arg Leu Arg Glu Arg Ile Glu 2225 2230 2235 2240 Arg Phe Gly Gln Arg Leu Ser Val Ala Ala Val Asn Ser Pro Gly Thr 2245 2250 2255 Ala Ala Val Ala Gly Asp Val Asp Ala Leu Arg Glu Leu Leu Ala Glu 2260 2265 2270 Leu Thr Ala Glu Gly Ile Arg Ala Lys Pro Ile Pro Gly Val Asp Thr 2275 2280 2285 Ala Gly His Ser Ala Gln Val Asp Gly Leu Lys Glu His Leu Phe Glu 2290 2295 2300 Val Leu Ala Pro Val Ser Pro Arg Ser Ser Asp Ile Pro Phe Tyr Ser 2305 2310 2315 2320 Thr Val Thr Gly Ala Pro Leu Asp Thr Glu Arg Leu Asp Ala Gly Tyr 2325 2330 2335 Trp Tyr Arg Asn Met Arg Glu Pro Val Glu Phe Glu Lys Ala Val Arg 2340 2345 2350 Ala Leu Ile Ala Asp Gly Tyr Asp Leu Phe Leu Glu Cys Asn Pro His 2355 2360 2365 Pro Met Leu Ala Met Ser Leu Asp Glu Thr Leu Thr Asp Ser Gly Gly 2370 2375 2380 His Gly Thr Val Met His Thr Leu Arg Arg Gln Lys Gly Ser Ala Lys 2385 2390 2395 2400 Asp Phe Gly Met Ala Leu Cys Leu Ala Tyr Val Asn Gly Leu Glu Ile 2405 2410 2415 Asp Gly Glu Ala Leu Phe Gly Pro Asp Ser Arg Arg Val Asn Pro Pro 2420 2425 2430 Thr Tyr Pro Phe Gln Arg Glu Arg Tyr Trp Tyr His Pro Thr Ser Gly 2435 2440 2445 Arg Arg Gly Asp Ile Thr Ala Ala Gly Val Ala Glu Ala Glu His Pro 2450 2455 2460 Leu Leu Gly Ala Gly Val Glu Leu Pro Glu Thr Gly Gly Thr Val Tyr 2465 2470 2475 2480 Thr Ala Arg Phe Gly Pro Asp Ser Arg Pro Trp Leu Ala Asp His Ala 2485 2490 2495 Leu Leu Gly Thr Val Leu Leu Pro Gly Thr Ala Ile Leu Asp Leu Val 2500 2505 2510 Leu Trp Ala Gly Glu Arg Ser Gly Cys Gly Arg Val Gly Glu Leu Ala 2515 2520 2525 Leu Gln Ala Pro Leu Val Leu Pro Asp Ser Gly Asp Val Glu Leu Arg 2530 2535 2540 Leu Leu Val Gly Gly Pro Asp Glu Glu Lys Arg Arg Thr Val Thr Val 2545 2550 2555 2560 His Ala Arg Pro Ala Ala Ala Gly Ala Glu Ala Pro Trp Thr Arg His 2565 2570 2575 Ala Glu Ala Val Val Leu Pro Ala Thr Gly Glu Glu Pro Thr Pro Ala 2580 2585 2590 Pro Arg Pro Val Pro Glu Pro Ala Gly Thr Thr Asp Pro Ala Ala Phe 2595 2600 2605 Tyr Ala Glu Phe Ala Glu Arg Gly Tyr Asp Tyr Gly Pro Ala Phe Gln 2610 2615 2620 Gly Phe Thr Ala Gly Ala Arg His Gly Glu Asp Val Val Ala Glu Val 2625 2630 2635 2640 Ala Leu Pro Ser Gly Leu Val Ala Asp Ala Arg His His Arg Leu His 2645 2650 2655 Pro Ala Leu Leu Asp Ala Ala Leu Gln Ala Met Ile Leu Gly Thr Phe 2660 2665 2670 Phe Ala Asp Asp Gly Arg Ala Arg Met Pro Phe Ala Val Arg Gly Val 2675 2680 2685 Arg Leu His Thr Ala Gly Ala Asp Arg Leu Arg Val Leu Ile Ser Pro 2690 2695 2700 Ala Gly Asp Glu Thr Val Arg Leu Leu Cys Thr Asp Leu Ala Thr Gly 2705 2710 2715 2720 Ala Pro Val Leu Glu Ile Asp Glu Leu Val Val Arg Pro Val Ser Gly 2725 2730 2735 Glu Gln Leu Ala Ala Gly Ala Pro Gly Arg Asn Gly Gly Glu Leu Tyr 2740 2745 2750 Arg Val Asp Trp Thr Val Leu Pro Glu Pro Ala Glu Val Pro Ala Pro 2755 2760 2765 Arg Trp Ala Leu Leu Gly Glu Asp His Ala Gly Leu Ala Asp Val Leu 2770 2775 2780 Gly Gly Thr Gly Gly Gly Cys Glu Arg Tyr Asp Thr Leu Thr Gly Leu 2785 2790 2795 2800 Leu Glu Ala Thr Thr Arg Ser Ala Gly Gly Ile Leu Pro Asp Ile Val 2805 2810 2815 Ala Leu Ser Leu Pro Thr Ala Pro Glu Pro Gly Pro Gln Ala Val Arg 2820 2825 2830 Glu Val Leu Ser Gln Ala Leu Asp Ala Ala Gln Ala Trp Leu Ala Ala 2835 2840 2845 Gly Ala Glu Thr Ala Ser Ala Arg Leu Val Phe Val Thr Gly Gly Ala 2850 2855 2860 Val Ala Thr Thr Ala Asp Glu Thr Val Arg Asp Ile Ala Ala Ala Ala 2865 2870 2875 2880 Val Trp Gly Leu Val Arg Ser Ala Gln Ser Glu Glu Pro Asp Arg Met 2885 2890 2895 Val Leu Leu Asp Leu Asp Gly Glu Arg Pro Thr Ala Arg Thr Leu Ala 2900 2905 2910 Ala Ala Leu Ala Ser Gly Glu Pro Gln Leu Ala Val Arg Gly Ser Thr 2915 2920 2925 Val Ala Ala Pro Arg Leu Ala Pro Ala Gly Pro Gly Pro Glu Asp Leu 2930 2935 2940 Val Pro Pro Ala Gly Thr Thr Ala Trp Arg Leu Thr Pro Gly Gly Gly 2945 2950 2955 2960 Thr Leu Glu Glu Leu Ser Leu Ala Pro Ala Pro Asp Ala Glu Glu Pro 2965 2970 2975 Leu Ala Pro Gly Gln Val Arg Ile Ala Val Arg Ala Ala Gly Val Asn 2980 2985 2990 Phe Arg Asp Ala Leu Ile Ala Leu Gly Met Tyr Pro Gly Lys Gly Thr 2995 3000 3005 Met Gly Ala Glu Gly Ala Gly Val Val Val Glu Thr Ala Pro Asp Val 3010 3015 3020 Thr Gly Leu Ser Ala Gly Asp Arg Val Leu Gly Met Trp Asn Gly Gly 3025 3030 3035 3040 Phe Gly Pro Leu Val Val Ala Asp His Arg Met Val Ala Pro Ile Pro 3045 3050 3055 His Gly Trp Ser Tyr Ala Glu Ala Ala Ser Val Pro Ala Val Leu Leu 3060 3065 3070 Thr Ser Tyr Tyr Ala Leu Thr Arg Leu Ala Arg Ala Arg Thr Gly Gln 3075 3080 3085 Thr Val Leu Val His Ala Ala Ala Gly Gly Val Gly Met Ala Thr Leu 3090 3095 3100 Gln Leu Ala Arg His Leu Gly Leu Glu Val Tyr Ala Thr Ala Ser Thr 3105 3110 3115 3120 Gly Lys Trp Asp Ala Leu Gln Lys His Gly Ile Pro Asp Asp Arg Ile 3125 3130 3135 Ala Asp Ser Arg Thr Leu Asp Phe Ala Glu Arg Phe Leu Ser Arg Thr 3140 3145 3150 Gly Gly Arg Gly Val Asp Ile Val Leu Asn Ser Leu Ala Gly Glu Phe 3155 3160 3165 Val Asp Ala Ser Leu Arg Leu Leu Pro Arg Gly Gly His Phe Leu Glu 3170 3175 3180 Leu Gly Lys Ala Asp Val Arg Asp Pro Arg Arg Ile Ala Ala Ala His 3185 3190 3195 3200 Pro Gly Thr Asp Tyr Arg Ala Phe Asp Leu Val Gln Ala Gly Pro Asp 3205 3210 3215 Thr Val Gly Glu Met Leu Gly Glu Leu Leu Glu Leu Phe Ala Ala Gly 3220 3225 3230 Ala Leu Arg Pro Leu Pro Leu Thr Ala Tyr Gly Ile Arg Asp Ala Arg 3235 3240 3245 Thr Ala Leu Arg Thr Leu Ser Gln Ala Arg His Thr Gly Lys Leu Val 3250 3255 3260 Leu Thr Val Pro Ala Gly Phe Asp Thr His Arg Thr Val Leu Leu Thr 3265 3270 3275 3280 Gly Gly Thr Gly Thr Leu Gly Gln Thr Leu Ala Arg His Leu Val Asn 3285 3290 3295 Arg His Gly Val Arg His Leu Leu Leu Ala Gly Arg Thr Gly Ala Ala 3300 3305 3310 Ala Glu Gly Val Ala Glu Leu Ile Gly Glu Leu Gly Glu Leu Gly Ala 3315 3320 3325 Glu Val Arg Val Ala Ala Cys Asp Ala Ala Asp Arg Gln Arg Leu Thr 3330 3335 3340 Glu Leu Leu Ala Gly Ile Pro Val Glu His Pro Leu Gly Ala Val Val 3345 3350 3355 3360 His Ala Ala Gly Thr Leu Asp Asp Gly Thr Ile Pro Ser Leu Thr Gly 3365 3370 3375 Glu Asn Ile Asp Asn Val Leu Arg Pro Lys Ala Asp Ala Val Leu Asn 3380 3385 3390 Leu His Glu Leu Thr Arg Asp Ala Asp Leu Ser Ala Phe Val Leu Tyr 3395 3400 3405 Ser Ser Ser Ser Ala Leu Leu Gly Ser Pro Gly Gln Gly Ala Tyr Ala 3410 3415 3420 Ala Ala Asn Ala Phe Leu Asp Gly Phe Ala Arg Tyr Arg Lys Gly Leu 3425 3430 3435 3440 Gly Leu Pro Ala Leu Ser Leu Ala Trp Gly Leu Trp Gly Ser Asn Ser 3445 3450 3455 Arg Met Ala Gly His Leu Asp Gln Ser Gly Met Gln Arg Arg Leu Asn 3460 3465 3470 Arg Ser Gly Ile Met Ala Leu Thr Asp Ala Glu Gly Leu Ala Leu Phe 3475 3480 3485 Asp Ala Ala Gln Asp Gly Gly Asp Ala Leu Leu Val Pro Met Arg Leu 3490 3495 3500 Asn Arg Thr Ala Leu Arg Ala Ser Gly Arg Ile Thr Pro Phe Leu Ser 3505 3510 3515 3520 Gly Leu Ala Gly Gly Gly Pro Ala Ala Gly Glu Arg Arg Pro Glu Val 3525 3530 3535 Ala Ala Val Ser Gly Thr Leu Ala Glu Arg Leu Thr Gly Leu Thr Ala 3540 3545 3550 Gln Glu Gly His Ala Leu Val Leu Ala Glu Ile Arg Ala His Ala Ala 3555 3560 3565 Ala Val Leu Gly His Gly Ser Asp Asp Ser Ile Pro Glu Asp Arg Ala 3570 3575 3580 Phe Lys Asp Leu Gly Phe Asp Ser Leu Thr Ala Val Glu Met Arg Asn 3585 3590 3595 3600 Arg Leu Ser Ala Ala Thr Gly Leu Arg Leu Pro Ala Thr Leu Val Phe 3605 3610 3615 Asp His Pro Thr Pro Gly Glu Leu Ala Gly His Leu Ser Ala Glu Leu 3620 3625 3630 Ser Ala Asp Asp Ala Pro Gly Ser Ala Ser Pro Leu Thr Glu Leu Asp 3635 3640 3645 Arg Phe Glu Ala Leu Phe Thr Ala Leu Ala Pro Gly Thr Thr Lys Asp 3650 3655 3660 Thr Pro Gly Gly Ala Gly Ala Leu Met Ile Asp Glu Ala Glu Arg Gln 3665 3670 3675 3680 Glu Ile Ala Gly Arg Leu Ala Ala Leu Ala Gly Leu Trp Asn Arg Leu 3685 3690 3695 His Gly Thr Thr Thr Ala Pro Glu Asp Gly Asp Thr Val Ala Asp Ala 3700 3705 3710 Leu Glu Ala Ala Asp Asp His Glu Ile Phe Ala Phe Leu Asp Glu Arg 3715 3720 3725 Phe * 3730

【００３９】配列番号:５配列の長さ：１６１２アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Ala Asn Ala Asn Glu Gln Gln Leu Arg Ala Tyr Leu Lys Arg Ala 1 5 10 15 Thr Thr Glu Leu His Arg Thr Ser Glu Gln Leu Arg Glu Glu Arg Ala 20 25 30 Arg Ala His Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg Tyr Pro 35 40 45 Gly Gly Ala Asn Thr Pro Glu Gln Phe Trp Glu Leu Leu Asp Thr Gly 50 55 60 Thr Asp Ala Ala Ala Pro Met Pro Ser Asp Arg Gly Trp Asp Thr His 65 70 75 80 Gly Leu Tyr Asp Pro Asp Pro Ala Ala Ala Gly Arg Thr Tyr Cys Arg 85 90 95 Glu Gly Gly Phe Leu His Asp Ala Gly Asp Phe Asp Ala Asp Phe Phe 100 105 110 Gly Ile Ser Pro Arg Glu Ala Val Ala Met Asp Pro Gln Gln Arg Leu 115 120 125 Leu Leu Glu Thr Ser Trp Glu Ala Ile Glu Ala Ala Gly Ile Asp Pro 130 135 140 Arg Gly Leu Arg Gly Ser Arg Thr Gly Val Tyr Val Gly Ala Trp Asp 145 150 155 160 Ser Gly Tyr Thr Gly Gln Ala His Ala Pro Ser Ala Glu Leu Glu Ala 165 170 175 Asp Leu Leu Thr Gly Gly Val Val Ser Phe Thr Ser Gly Arg Ile Ala 180 185 190 Tyr Thr Leu Gly Leu Glu Gly Pro Ala Leu Thr Val Asp Thr Ala Cys 195 200 205 Ser Ser Ser Leu Val Ala Leu His Asn Ala Ala Gln Ala Leu Arg Arg 210 215 220 Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr 225 230 235 240 Pro Ala Val Phe Val Gln Phe Ala Arg Gln Arg Gly Leu Ala Pro Asp 245 250 255 Gly Arg Cys Lys Ala Phe Ala Asp Ala Ala Asp Gly Phe Gly Pro Ala 260 265 270 Glu Gly Val Gly Met Val Leu Val Glu Arg Leu Ser Asp Ala Arg Arg 275 280 285 Leu Gly His Pro Val Leu Ala Val Val Cys Gly Ser Ala Val Asn Gln 290 295 300 Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ser Gln Glu 305 310 315 320 Arg Val Ile Arg Gln Ala Leu Gly Asn Ala Arg Leu Thr Val Ala Asp 325 330 335 Val Asp Val Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly Asp Pro 340 345 350 Ile Glu Ala Gln Ala Leu Leu Gly Thr Tyr Gly Arg Asp Arg Asp Gly 355 360 365 Gly Arg Pro Val Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala 370 375 380 Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys Met Val Leu Ala Met 385 390 395 400 Arg Tyr Gly Trp Leu Pro Arg Thr Leu His Val Asp Glu Pro Ser Arg 405 410 415 His Val Asp Trp Ser Ala Gly Gly Val Arg Leu Leu Thr Glu Ala Arg 420 425 430 Glu Trp Pro Gly Val Asp Arg Pro Arg Arg Ala Ala Val Ser Ala Phe 435 440 445 Gly Val Ser Gly Thr Asn Ala His Leu Ile Leu Glu Ala Pro Asp Thr 450 455 460 Ala Glu Ala Glu Ser Ala Thr Thr Pro Val Arg Ser Glu Val Ser Glu 465 470 475 480 Ser Ala Ala Val Leu Asp Ala Arg Ser Gly Val Val Pro Val Val Val 485 490 495 Ser Gly Arg Ser Arg Val Val Val Arg Glu Ala Ala Gly Arg Leu Ala 500 505 510 Glu Val Val Glu Ala Gly Gly Val Gly Leu Ala Asp Val Ala Val Thr 515 520 525 Met Ala Gly Arg Ser Arg Phe Gly Tyr Arg Ala Val Val Leu Ala Arg 530 535 540 Gly Glu Ala Glu Leu Ala Gly Arg Leu Arg Ala Leu Ala Gly Gly Asp 545 550 555 560 Pro Asp Ala Gly Val Val Thr Gly Ala Val Val Asp Pro Glu Thr Gly 565 570 575 Ser Gly Gly Gly Gly Val Val Leu Val Phe Pro Gly Gln Gly Thr Gln 580 585 590 Trp Val Gly Met Gly Ala Gly Leu Leu Gly Ser Ser Glu Val Phe Ala 595 600 605 Ala Ser Met Arg Glu Cys Ala Arg Ala Leu Ser Val His Val Gly Trp 610 615 620 Asp Leu Leu Glu Val Val Ser Gly Gly Ala Gly Leu Glu Arg Val Asp 625 630 635 640 Val Val Gln Pro Val Thr Trp Ala Val Met Val Ser Leu Ala Arg Tyr 645 650 655 Trp Gln Ala Met Gly Val Asp Val Ala Ala Val Val Gly His Ser Gln 660 665 670 Gly Glu Ile Ala Ala Ala Thr Val Ala Gly Ala Leu Ser Leu Glu Asp 675 680 685 Ala Ala Ala Val Val Ala Leu Arg Ala Gly Leu Ile Gly Arg Tyr Leu 690 695 700 Ala Gly Arg Gly Ala Met Ala Ala Val Pro Leu Pro Ala Gly Glu Val 705 710 715 720 Glu Ala Gly Leu Ala Lys Trp Pro Gly Val Glu Val Ala Ala Val Asn 725 730 735 Gly Pro Ala Ser Thr Val Val Ser Gly Asp Arg Arg Ala Val Ala Gly 740 745 750 Tyr Val Ala Val Cys Gln Ala Glu Gly Val Gln Ala Arg Leu Ile Pro 755 760 765 Val Asp Tyr Ala Ser His Ser Arg His Val Glu Asp Leu Lys Gly Glu 770 775 780 Leu Glu Arg Val Leu Ser Gly Ile Arg Pro Arg Ser Pro Arg Val Pro 785 790 795 800 Val Cys Ser Thr Val Ala Gly Glu Gln Pro Gly Glu Pro Val Phe Asp 805 810 815 Ala Gly Tyr Trp Phe Arg Asn Leu Arg Asn Arg Val Glu Phe Ser Ala 820 825 830 Val Val Gly Gly Leu Leu Glu Glu Gly His Arg Arg Phe Ile Glu Val 835 840 845 Ser Ala His Pro Val Leu Val His Ala Ile Glu Gln Thr Ala Glu Ala 850 855 860 Ala Asp Arg Ser Val His Ala Thr Gly Thr Leu Arg Arg Gln Asp Asp 865 870 875 880 Ser Pro His Arg Leu Leu Thr Ser Thr Ala Glu Ala Trp Ala His Gly 885 890 895 Ala Thr Leu Thr Trp Asp Pro Ala Leu Pro Pro Gly His Leu Thr Thr 900 905 910 Leu Pro Thr Tyr Pro Phe Asn His His His Tyr Trp Leu Asp Thr Thr 915 920 925 Pro Thr Thr Pro Ala Thr Thr Thr Gln Ser Pro Thr Asp Ala Trp Arg 930 935 940 Tyr Arg Val Thr Trp Lys Ala Leu Thr Glu Glu Ser Thr Pro Ala Ser 945 950 955 960 Ser Pro Ser Gly His Trp Leu Leu Val Thr Pro Pro Thr Pro Glu Gly 965 970 975 Arg Thr Leu Gly Asp Arg Ala Ala Gly Ala Leu Ala Arg Gln Gly Ala 980 985 990 Thr Val Glu Arg Leu Val Val Asp Pro Val Ala Val Gly Arg Asp Gly 995 1000 1005 Leu Ala Ala Arg Leu Gly Glu Arg Trp Asp Gly Val Leu Ser Leu Leu 1010 1015 1020 Gly Ala Asp Glu Arg Pro Leu Pro Arg His Pro Ala Leu Asn Arg Ala 1025 1030 1035 1040 Val Met Gly Thr Thr Leu Leu Ala Gln Ala Ala Leu Asp Ala Gly Cys 1045 1050 1055 Glu Ala Arg Ile Trp Ala Val Thr Arg Glu Ala Val Ala Val Ser Pro 1060 1065 1070 Ser Glu Val Pro Arg Asp Ala Gly Ala Gln Leu Trp Gly Leu Gly Arg 1075 1080 1085 Gly Ile Ala Leu Glu His Pro Ser Leu Trp Gly Gly Leu Ile Asp Leu 1090 1095 1100 Pro Ala Val Pro Asp Glu Arg Ala Trp Ala Arg Ala Val Arg Arg Leu 1105 1110 1115 1120 Val Pro His Gly Glu Asp Gln Ile Ala Ala Arg Ala Ser Gly Ala Tyr 1125 1130 1135 Gly Arg Arg Leu Leu Pro Ala Pro Pro Ala Ala Ser Arg Arg Thr Cys 1140 1145 1150 Thr Pro Ser Gly Thr Val Leu Val Thr Gly Gly Thr Gly Ala Leu Gly 1155 1160 1165 Gly His Leu Ala Arg Arg Leu Ala Arg Gly Gly Thr Gly His Leu Val 1170 1175 1180 Leu Thr Ser Arg Arg Gly Pro Asp Ala Pro Gly Ala Gly Glu Leu Ala 1185 1190 1195 1200 Gly Glu Leu Ala Ser Leu Gly Ala Lys Val Thr Val Ala Ala Cys Asp 1205 1210 1215 Met Ala Asp Arg Glu Ala Val Arg Ala Leu Leu Asp Glu His Arg Pro 1220 1225 1230 Thr Ala Val Phe His Thr Ala Gly Thr Pro His Ser Ala Glu Phe Thr 1235 1240 1245 Ala Leu Asp Glu Thr Thr Thr Ala Gly Val Tyr Gly Gly Lys Val Leu 1250 1255 1260 Gly Ala Arg His Leu Asp Glu Leu Thr Arg Glu Leu Gly Ile Gly Leu 1265 1270 1275 1280 Asp Ala Phe Val Leu Phe Ser Ser Gly Ala Ala Val Trp Gly Ser Gly 1285 1290 1295 Gly Gln Thr Ala Tyr Gly Ala Ala Asn Ala Ala Leu Asp Ala Leu Ala 1300 1305 1310 Glu Arg Arg Arg Ala Ala Gly Leu Pro Ala Thr Ser Val Ala Trp Gly 1315 1320 1325 Leu Trp Gly Gly Gly Gly Met Gly Glu Gly Asp Gly Glu Glu Phe Leu 1330 1335 1340 Ser Arg Arg Gly Leu Gly Val Met Pro Pro Glu Asp Ala Leu Glu Ala 1345 1350 1355 1360 Leu Asp Arg Ala Leu Asp Arg Glu Asp Thr Thr Val Val Val Ala Asp 1365 1370 1375 Val Asp Trp Glu Arg Phe Ala Pro Ala Phe Thr Ala Phe Arg Pro Ser 1380 1385 1390 Ala Leu Ile Ser Arg Leu Val Ser Asp Gly Gly Glu Ala Gly Gly Gln 1395 1400 1405 Asp Ala Pro Asp Gly Thr Leu Phe Ala Ala Gly Phe Ala Ala Ala Gly 1410 1415 1420 Pro Leu Glu Arg Gln Glu Met Leu Leu Gly Leu Val Arg Arg His Val 1425 1430 1435 1440 Ala Ala Val Leu Gly His Pro Gly Thr Ala Asp Ile Gly Pro Asp Arg 1445 1450 1455 Ala Phe Lys Glu Leu Gly Phe Ser Ser Val Thr Ala Val Glu Leu Ala 1460 1465 1470 Gly Arg Leu Gly Arg Glu Cys Gly Arg Lys Leu Pro Pro Thr Leu Val 1475 1480 1485 Phe Asp His Pro Thr Ala Ala Ala Ala Val Glu His Leu Ala Glu Leu 1490 1495 1500 Leu Thr Pro Pro Ala Gly Pro Ala Ala Gly Pro Arg Glu Glu Glu Ala 1505 1510 1515 1520 Arg Ala Ala Leu Ala Arg Val Pro Leu Glu Arg Leu Arg Glu Ala Gly 1525 1530 1535 Leu Leu Asp Ala Leu Leu Arg Leu Ala Ala Asp Glu Ser Gly Ala Thr 1540 1545 1550 Thr Pro Arg Thr Ser Ala Ala Ser Gly Ala Pro Arg Gly Arg Glu Glu 1555 1560 1565 Pro Asp Gly Arg Gly Glu Pro Asp Gly Ser Gly His Arg Glu Ser Pro 1570 1575 1580 Asp Ala Ala Gly Gly Ser Asp Ala Leu Asp Asp Leu Asp Gly Asp Ala 1585 1590 1595 1600 Leu Val Arg Leu Ala Leu Gly Glu Pro Gly Glu * 1605 1610

【００４０】配列番号：６配列の長さ：１８４２アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Ala Met Ser Ala Glu Arg Leu Thr Glu Ala Leu Arg Thr Ser Leu 1 5 10 15 Lys Glu Ala Glu Arg Leu Arg Arg Gln Asn Arg Glu Leu Arg Ala Ala 20 25 30 Arg Asp Ala Ala Arg Glu Pro Ile Ala Val Val Gly Met Ala Cys Arg 35 40 45 Tyr Pro Gly Gly Val Thr Gly Pro Glu Glu Leu Trp Glu Leu Val Ala 50 55 60 Gly Gly Arg Asp Ala Ile Gly Pro Phe Pro Val Asp Arg Gly Trp Asp 65 70 75 80 Val Ala Ser Val Tyr Asp Pro Asp Pro Glu Ser Lys Gly Thr Thr Tyr 85 90 95 Cys Arg Glu Gly Gly Phe Leu Glu Gly Ala Gly Asp Phe Asp Ala Ala 100 105 110 Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Val Met Asp Pro Gln Gln 115 120 125 Arg Leu Leu Leu Glu Val Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile 130 135 140 Asp Pro Ser Ser Leu Arg Gly Ser Arg Gly Gly Val Tyr Val Gly Ala 145 150 155 160 Ala His Gly Ser Tyr Ala Ser Asp Pro Arg Leu Val Pro Glu Gly Ser 165 170 175 Glu Gly Tyr Leu Leu Thr Gly Ser Ala Asp Ala Val Met Ser Gly Arg 180 185 190 Ile Ser Tyr Ala Leu Gly Leu Glu Gly Pro Ser Met Thr Val Glu Thr 195 200 205 Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Arg Ala Leu 210 215 220 Arg His Gly Glu Cys Gly Leu Ala Leu Ala Gly Gly Val Ala Val Met 225 230 235 240 Ala Asp Pro Ala Ala Phe Val Glu Phe Ser Arg Gln Lys Gly Leu Ala 245 250 255 Ala Asp Gly Arg Cys Lys Ala Phe Ser Ala Ala Ala Asp Gly Thr Gly 260 265 270 Trp Ala Glu Gly Val Gly Val Leu Val Leu Glu Arg Leu Ser Asp Ala 275 280 285 Arg Arg Ala Gly His Thr Val Leu Gly Leu Val Thr Gly Thr Ala Val 290 295 300 Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Gly Pro Ala 305 310 315 320 Gln Gln Arg Val Ile Ala Glu Ala Leu Ala Asp Ala Gly Leu Ser Pro 325 330 335 Glu Asp Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Arg Leu Gly 340 345 350 Asp Pro Ile Glu Ala Gly Ala Leu Leu Ala Ala Ser Gly Arg Asn Arg 355 360 365 Ser Gly Asp His Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly 370 375 380 His Ala Gln Ala Ala Ala Gly Val Gly Gly Val Ile Lys Met Leu Gln 385 390 395 400 Ala Leu Arg His Gly Leu Leu Pro Arg Thr Leu His Ala Asp Glu Pro 405 410 415 Thr Pro His Ala Asp Trp Ser Ser Gly Arg Val Arg Leu Leu Thr Ser 420 425 430 Glu Val Pro Trp Gln Arg Thr Gly Arg Pro Arg Arg Thr Gly Val Ser 435 440 445 Ala Phe Gly Val Gly Gly Thr Asn Ala His Val Val Leu Glu Glu Ala 450 455 460 Pro Ala Pro Pro Ala Pro Glu Pro Ala Gly Glu Ala Pro Gly Gly Ser 465 470 475 480 Arg Ala Ala Glu Gly Ala Glu Gly Pro Leu Ala Trp Val Val Ser Gly 485 490 495 Arg Asp Glu Pro Ala Leu Arg Ser Gln Ala Arg Arg Leu Arg Asp His 500 505 510 Leu Ser Arg Thr Pro Gly Ala Arg Pro Arg Asp Ile Ala Phe Ser Leu 515 520 525 Ala Ala Thr Arg Ala Ala Phe Asp His Arg Ala Val Leu Ile Gly Ser 530 535 540 Asp Gly Ala Glu Leu Ala Ala Ala Leu Asp Ala Leu Ala Glu Gly Arg 545 550 555 560 Asp Gly Pro Ala Val Val Arg Gly Val Arg Asp Arg Asp Gly Arg Met 565 570 575 Ala Phe Leu Phe Thr Gly Gln Gly Ser Gln Arg Ala Gly Met Ala His 580 585 590 Asp Leu His Ala Ala His Thr Phe Phe Ala Ser Ala Leu Asp Glu Val 595 600 605 Thr Asp Arg Leu Asp Pro Leu Leu Gly Arg Pro Leu Gly Ala Leu Leu 610 615 620 Asp Ala Arg Pro Gly Ser Pro Glu Ala Ala Leu Leu Asp Arg Thr Glu 625 630 635 640 Tyr Thr Gln Pro Ala Leu Phe Ala Val Glu Val Ala Leu His Arg Leu 645 650 655 Leu Glu His Trp Gly Met Arg Pro Asp Leu Leu Leu Gly His Ser Val 660 665 670 Gly Glu Leu Ala Ala Ala His Val Ala Gly Val Leu Asp Leu Asp Asp 675 680 685 Ala Cys Ala Leu Val Ala Ala Arg Gly Arg Leu Met Gln Arg Leu Pro 690 695 700 Pro Gly Gly Ala Met Val Ser Val Arg Ala Gly Glu Asp Glu Val Arg 705 710 715 720 Ala Leu Leu Ala Gly Arg Glu Asp Ala Val Cys Val Ala Ala Val Asn 725 730 735 Gly Pro Arg Ser Val Val Ile Ser Gly Ala Glu Glu Ala Val Ala Glu 740 745 750 Ala Ala Ala Gln Leu Ala Gly Arg Gly Arg Arg Thr Arg Arg Leu Arg 755 760 765 Val Ala His Ala Phe His Ser Pro Leu Met Asp Gly Met Leu Ala Gly 770 775 780 Phe Arg Glu Val Ala Ala Gly Leu Arg Tyr Arg Glu Pro Glu Leu Thr 785 790 795 800 Val Val Ser Thr Val Thr Gly Arg Pro Ala Arg Pro Gly Glu Leu Thr 805 810 815 Gly Pro Asp Tyr Trp Val Ala Gln Val Arg Glu Pro Val Arg Phe Ala 820 825 830 Asp Ala Val Arg Thr Ala His Arg Leu Gly Ala Arg Thr Phe Leu Glu 835 840 845 Thr Gly Pro Asp Gly Val Leu Cys Gly Met Ala Glu Glu Cys Leu Glu 850 855 860 Asp Asp Thr Val Ala Leu Leu Pro Ala Ile His Lys Pro Gly Thr Ala 865 870 875 880 Pro His Gly Pro Ala Ala Pro Gly Ala Leu Arg Ala Ala Ala Ala Ala 885 890 895 Tyr Gly Arg Gly Ala Arg Val Asp Trp Ala Gly Met His Ala Asp Gly 900 905 910 Pro Glu Gly Pro Ala Arg Arg Val Glu Leu Pro Val His Ala Phe Arg 915 920 925 His Arg Arg Tyr Trp Leu Ala Pro Gly Arg Ala Ala Asp Thr Asp Asp 930 935 940 Trp Met Tyr Arg Ile Gly Trp Asp Arg Leu Pro Ala Val Thr Gly Gly 945 950 955 960 Ala Arg Thr Ala Gly Arg Trp Leu Val Ile His Pro Asp Ser Pro Arg 965 970 975 Cys Arg Glu Leu Ser Gly His Ala Glu Arg Ala Leu Arg Ala Ala Gly 980 985 990 Ala Ser Pro Val Pro Leu Pro Val Asp Ala Pro Ala Ala Asp Arg Ala 995 1000 1005 Ser Phe Ala Ala Leu Leu Arg Ser Ala Thr Gly Pro Asp Thr Arg Gly 1010 1015 1020 Asp Thr Ala Ala Pro Val Ala Gly Val Leu Ser Leu Leu Ser Glu Glu 1025 1030 1035 1040 Asp Arg Pro His Arg Gln His Ala Pro Val Pro Ala Gly Val Leu Ala 1045 1050 1055 Thr Leu Ser Leu Met Gln Ala Met Glu Glu Glu Ala Val Glu Ala Arg 1060 1065 1070 Val Trp Cys Val Ser Arg Ala Ala Val Ala Ala Ala Asp Arg Glu Arg 1075 1080 1085 Pro Val Gly Ala Gly Ala Ala Leu Trp Gly Leu Gly Arg Val Ala Ala 1090 1095 1100 Leu Glu Arg Pro Thr Arg Trp Gly Gly Leu Val Asp Leu Pro Ala Ser 1105 1110 1115 1120 Pro Gly Ala Ala His Trp Ala Ala Ala Val Glu Arg Leu Ala Gly Pro 1125 1130 1135 Glu Asp Gln Ile Ala Val Arg Ala Ser Gly Ser Trp Gly Arg Arg Leu 1140 1145 1150 Thr Arg Leu Pro Arg Asp Gly Gly Gly Arg Thr Ala Ala Pro Ala Tyr 1155 1160 1165 Arg Pro Arg Gly Thr Val Leu Val Thr Gly Gly Thr Gly Ala Leu Gly 1170 1175 1180 Gly His Leu Ala Arg Trp Leu Ala Ala Ala Gly Ala Glu His Leu Ala 1185 1190 1195 1200 Leu Thr Ser Arg Arg Gly Pro Asp Ala Pro Gly Ala Ala Gly Leu Glu 1205 1210 1215 Ala Glu Leu Leu Leu Leu Gly Ala Lys Val Thr Phe Ala Ala Cys Asp 1220 1225 1230 Thr Ala Asp Arg Asp Gly Leu Ala Arg Val Leu Arg Ala Ile Pro Glu 1235 1240 1245 Asp Thr Pro Leu Thr Ala Val Phe His Ala Ala Gly Val Pro Gln Val 1250 1255 1260 Thr Pro Leu Ser Arg Thr Ser Pro Glu His Phe Ala Asp Val Tyr Ala 1265 1270 1275 1280 Gly Lys Ala Ala Gly Ala Ala His Leu Asp Glu Leu Thr Arg Glu Leu 1285 1290 1295 Gly Ala Gly Leu Asp Ala Phe Val Leu Tyr Ser Ser Gly Ala Gly Val 1300 1305 1310 Trp Gly Ser Ala Gly Gln Gly Ala Tyr Ala Ala Ala Asn Ala Ala Leu 1315 1320 1325 Asp Ala Leu Ala Arg Arg Arg Ala Ala Asp Gly Leu Pro Ala Thr Ser 1330 1335 1340 Ile Ala Trp Gly Val Trp Gly Gly Gly Gly Met Gly Ala Asp Glu Ala 1345 1350 1355 1360 Gly Ala Glu Tyr Leu Gly Arg Arg Gly Met Arg Pro Met Ala Pro Val 1365 1370 1375 Ser Ala Leu Arg Ala Met Ala Thr Ala Ile Ala Ser Gly Glu Pro Cys 1380 1385 1390 Pro Thr Val Thr His Thr Asp Trp Glu Arg Phe Gly Glu Gly Phe Thr 1395 1400 1405 Ala Phe Arg Pro Ser Pro Leu Ile Ala Gly Leu Gly Thr Pro Gly Gly 1410 1415 1420 Gly Arg Ala Ala Glu Thr Pro Glu Glu Gly Asn Ala Thr Ala Ala Ala 1425 1430 1435 1440 Asp Leu Thr Ala Leu Pro Pro Ala Glu Leu Arg Thr Ala Leu Arg Glu 1445 1450 1455 Leu Val Arg Ala Arg Thr Ala Ala Ala Leu Gly Leu Asp Asp Pro Ala 1460 1465 1470 Glu Val Ala Glu Gly Glu Arg Phe Pro Ala Met Gly Phe Asp Ser Leu 1475 1480 1485 Ala Thr Val Arg Leu Arg Arg Gly Leu Ala Ser Ala Thr Gly Leu Asp 1490 1495 1500 Leu Pro Pro Asp Leu Leu Phe Asp Arg Asp Thr Pro Ala Ala Leu Ala 1505 1510 1515 1520 Ala His Leu Ala Glu Leu Leu Ala Thr Ala Arg Asp His Gly Pro Gly 1525 1530 1535 Gly Pro Gly Thr Gly Ala Ala Pro Ala Asp Ala Gly Ser Gly Leu Pro 1540 1545 1550 Ala Leu Tyr Arg Glu Ala Val Arg Thr Gly Arg Ala Ala Glu Met Ala 1555 1560 1565 Glu Leu Leu Ala Ala Ala Ser Arg Phe Arg Pro Ala Phe Gly Thr Ala 1570 1575 1580 Asp Arg Gln Pro Val Ala Leu Val Pro Leu Ala Asp Gly Ala Glu Asp 1585 1590 1595 1600 Thr Gly Leu Pro Leu Leu Val Gly Cys Ala Gly Thr Ala Val Ala Ser 1605 1610 1615 Gly Pro Val Glu Phe Thr Ala Phe Ala Gly Ala Leu Ala Asp Leu Pro 1620 1625 1630 Ala Ala Ala Pro Met Ala Ala Leu Pro Gln Pro Gly Phe Leu Pro Gly 1635 1640 1645 Glu Arg Val Pro Ala Thr Pro Glu Ala Leu Phe Glu Ala Gln Ala Glu 1650 1655 1660 Ala Leu Leu Arg Tyr Ala Ala Gly Arg Pro Phe Val Leu Leu Gly His 1665 1670 1675 1680 Ser Ala Gly Ala Asn Met Ala His Ala Leu Thr Arg His Leu Glu Ala 1685 1690 1695 Asn Gly Gly Gly Pro Ala Gly Leu Val Leu Met Asp Ile Tyr Thr Pro 1700 1705 1710 Ala Asp Pro Gly Ala Met Gly Val Trp Arg Asn Asp Met Phe Gln Trp 1715 1720 1725 Val Trp Arg Arg Ser Asp Ile Pro Pro Asp Asp His Arg Leu Thr Ala 1730 1735 1740 Met Gly Ala Tyr His Arg Leu Leu Leu Asp Trp Ser Pro Thr Pro Val 1745 1750 1755 1760 Arg Ala Pro Val Leu His Leu Arg Ala Ala Glu Pro Met Gly Asp Trp 1765 1770 1775 Pro Pro Gly Asp Thr Gly Trp Gln Ser His Trp Asp Gly Ala His Thr 1780 1785 1790 Thr Ala Gly Ile Pro Gly Asn His Phe Thr Met Met Thr Glu His Ala 1795 1800 1805 Ser Ala Ala Ala Arg Leu Val His Gly Trp Leu Ala Glu Arg Thr Pro 1810 1815 1820 Ser Gly Gln Gly Gly Ser Pro Ser Arg Ala Ala Gly Arg Glu Glu Arg 1825 1830 1835 1840 Pro *

【００４１】配列番号：７配列の長さ：４４３７７塩基対配列の型：核酸鎖の数：一本鎖トポロジー：直鎖状配列の種類：ＤＮＡ（genomic）配列の特徴特徴を表す記号：ＣＤＳ存在位置：３５０．．１４００２配列の特徴特徴を表す記号：ＣＤＳ存在位置：１４０４６．．２００３６配列の特徴特徴を表す記号：ＣＤＳ存在位置：２０１１０．．３１２８４配列の特徴特徴を表す記号：ＣＤＳ存在位置：３１３２９．．３６０７１配列の特徴特徴を表す記号：ＣＤＳ存在位置：３６１５５．．４１８３０配列 GACCGCTCGG GGAGACCTGA CATATTCGTC GCGAAGTGGT TGTCCGCGCC GCGAGGTACT 60 GAAATCTTCT CCGCTCGCCC AGGACTCCGC GTGCAGGTCA CCGGAGTGCG CGACCGGCCG 120 GGACGTCGGA GCGCCGACCC TGCGGACCTG GTGCGATGCC GTGTGGTCCC GCATGATCCC 180 GCGCCGTCTC CGGTGACGAG AATCGGTGGA CAATCTCCGA ACTTGACACA ATTGATTGTC 240 GTTCACCGGC CGTTCCTGTC GCCCGGCAGT TCGCCCGCTG TACGCTCGGG AAGATCAAGA 300 AAAGGCAGAA AAGCCACGGC GTGGTACGGC GAACATATGA GGGATGCAGG TGTCTGGAGA 360 ACTCGCGATT TCCCGCAGTG ACGACCGGTC CGACGCCGTT GCCGTGGTCG GAATGGCGTG 420 CCGGTTTCCC GGCGCCCCGG GAATTGCCGA ATTCTGGAAA CTGCTGACCG ACGGAAGGGA 480 CGCGATCGGC CGGGACGCCG ACGGCCGCCG GCGCGGCATG ATCGAGGCGC CCGGCGACTT 540 CGACGCCGCC TTCTTCGGCA TGTCACCCCG CGAGGCCGCC GAGACCGACC CCCAGCAGCG 600 CCTGATGCTC GAACTCGGCT GGGAGGCTCT GGAGGACGCC GGCATCGTCC CCGGCTCCCT 660 GCGCGGCGAG GCGGTCGGCG TCTTCGTCGG GGCCATGCAC GACGACTACG CCACCCTGCT 720 CCACCGCGCC GGCGCGCCGG TCGGCCCCCA CACCGCCACC GGCCTCCAGC GCGCCATGCT 780 CGCCAACCGG CTCTCCTACG TCCTGGGGAC GCGCGGCCCC AGCCTCGCGG TCGACACCGC 840 CCAGTCGTCC TCCCTGGTCG CCGTGGCCCT CGCCGTCGAG AGCCTGCGGG CCGGCACCTC 900 CCGCGTCGCC GTCGCCGGGG GCGTCAACCT GGTCCTCGCC GACGAGGGAA CGGCCGCCAT 960 GGAACGCCTC GGCGCGCTGT CACCCGACGG CCGCTGCCAC ACCTTCGACG CCCGTGCCAA 1020 CGGCTATGTC CGCGGTGAGG GCGGCGCCGC CGTCGTCCTG AAGCCCCTCG CCGACGCCCT 1080 GGCCGACGGG GACCCCGTGT ACTGCGTGGT GCGTGGCGTC GCCGTCGGCA ACGACGGCGG 1140 CGGCCCCGGG CTGACCGCTC CCGACCGCGA GGGACAGGAG GCGGTGCTCC GGGCCGCCTG 1200 CGCCCAGGCC CGGGTCGACC CCGCCGAGGT GCGTTTCGTC GAACTGCACG GCACGGGAAC 1260 CCCGGTGGGC GACCCGGTCG AGGCACACGC CCTCGGCGCG GTGCACGGCT CCGGTCGGCC 1320 GGCCGACGAC CCCCTGCTGG TGGGGTCGGT GAAGACCAAC ATCGGCCACC TGGAGGGCGC 1380 CGCCGGCATC GCGGGCCTGG TCAAGGCCGC ACTGTGCCTG CGGGAACGCA CCCTTCCCGG 1440 CTCGCTGAAC TTCGCCACCC CCTCTCCGGC CATCCCGCTG GACCAGCTCC GGCTGAAGGT 1500 GCAGACCGCT GCCGCCGAGC TGCCGCTCGC CCCGGGCGGC GCACCCCTGC TGGCGGGTGT 1560 CAGTTCGTTC GGCATCGGTG GCACCAACTG CCATGTGGTC CTGGAACACC TGCCCTCCCG 1620 GCCCACCCCG GCCGTCTCCG TCGCCGCCTC GCTTCCGGAC GTCCCGCCGC TGTTGTTGTC 1680 CGCGCGGTCG GAGGGGGCGT TGCGGGCGCA GGCGGTGCGG TTGGGTGAGT ACGTGGAGCG 1740 GGTGGGCGCG GATCCGCGGG ATGTGGCTTA TTCGCTGGCT TCGACGCGGA CTCTTTTCGA 1800 GCACCGTGCG GTGGTGCCGT GTGGTGGGCG TGGGGAGCTC GTCGCTGCTC TTGGTGGGTT 1860 TGCTGCCGGG AGGGTGTCTG GGGGTGTGCG GTCCGGGCGG GCTGTGCCGG GTGGGGTGGG 1920 GGTGTTGTTC ACGGGTCAGG GTGCGCAGTG GGTTGGTATG GGGCGTGGGT TGTATGCGGG 1980 GGGTGGGGTG TTTGCGGAGG TGCTGGATGA GGTGTTGTCG ATGGTGGGGG AGGTGGATGG 2040 TCGGTCGTTG CGGGATGTGA TGTTCGGCGA CGTCGACGTG GACGCGGGTG CCGGGGCTGA 2100 TGCGGGTGCC GGTGCGGGTG CTGGGGTCGG TTCTGGTTCC GGTTCTGTGG GTGGGTTGTT 2160 GGGTCGGACG GAGTTTGCTC AGCCTGCGTT GTTTGCGTTG GAGGTGGCGT TGTTCCGGGC 2220 GTTGGAGGCT CGGGGTGTGG AGGTGTCGGT GGTGTTGGGT CATTCGGTGG GGGAGGTGGC 2280 TGCTGCGTAT GTGGCGGGGG TGTTGTCGTT GGGTGATGCG GTGCGGTTGG TGGTGGCGCG 2340 GGGTGGGTTG ATGGGTGGGT TGCCGGTGGG TGGGGGGATG TGGTCGGTGG GGGCGTCGGA 2400 GTCGGTGGTG CGGGGGGTTG TTGAGGGGTT GGGGGAGTGG GTGTCGGTTG CGGCGGTGAA 2460 TGGGCCGCGG TCGGTGGTGT TGTCGGGTGA TGTGGGTGTG CTGGAGTCGG TGGTTGCCTC 2520 GCTGATGGGG GATGGGGTGG AGTGCCGGCG GTTGGATGTG TCGCATGGGT TTCATTCGGT 2580 GTTGATGGAG CCGGTGTTGG GGGAGTTCCG GGGGGTTGTG GAGTCGTTGG AGTTCGGTCG 2640 GGTGCGGCCG GGTGTGGTGG TGGTGTCGGG TGTGTCGGGT GGGGTGGTGG GTTCGGGGGA 2700 GTTGGGGGAT CCGGGGTATT GGGTGCGTCA TGCGCGGGAG GCGGTGCGTT TCGCGGATGG 2760 GGTGGGGGTG GTGCGTGGTC TGGGTGTGGG GACGTTGGTG GAGGTGGGTC CGCATGGGGT 2820 GCTGACGGGG ATGGCGGGTG AGTGCCTGGG GGCCGGTGAT GATGTGGTGG TGGTGCCGGC 2880 GATGCGGCGG GGCCGTGCGG AGCGGGAGGT GTTCGAGGCG GCGCTGGCGA CGGTGTTCAC 2940 CCGGGACGCC GGCCTGGACG CCACGGCACT CCACACCGGG AGCACCGGCC GGCGCATCGA 3000 CCTCCCCACC TACCCCTTCC AACGCCGTAC CCACTGGTCG CCCGCGCTGA GCCGGCCGGT 3060 CACGGCCGAC GCCGGGGCGG GTGTGACCGC CACCGATGCC GTGGGGCACA GCGTCTCCCC 3120 GGACCCGGAG AGCACCGAGG GGACGTCCCA CAGGGACACG GACGACGAGG CGGACTCGGC 3180 GTCACCGGAG CCGATGTCCC CCGAGGATGC CGTCCGCCTG GTCCGCGAGA GCACCGCGGC 3240 CGTCCTGGGC CACGACGATC CCGGCGAGGT CGCGCTCGAC CGCACCTTCA CCTCCCAGGG 3300 CATGGACTCG GTGACCGCGG TCGAGCTGTG CGACCTGCTG AAGGGCGCCT CGGGGCTCCC 3360 CCTCGCCGCC ACGCTGGTCT ACGACCTGCC CACCCCGCGT GCCGTCGCCG AGCACATCGT 3420 GGAAGCCGCG GGCGGGCCGA AGGACTCGGT TGCCGGTGGG CCCGGAGTGC TCTCGTCGGC 3480 CGCGGTAGGG GTGTCGGACG CCCGGGGCGG CAGCCGGGAC GACGACGACC CGATCGCCAT 3540 CGTGGGTGTC GGCTGCCGGC TCCCCGGCGG CGTCGACTCG CGCGCCGCTC TCTGGGAGCT 3600 GCTGGAGTCC GGCGCCGACG CCATCTCGTC CTTCCCCACC GACCGCGGCT GGGACCTCGA 3660 CGGGCTGTAC GACCCCGAGC CCGGGACGCC CGGCAAGACC TATGTGCGGG AGGGCGGGTT 3720 CCTGCACTCG GCGGCCGAGT TCGACGCGGA GTTCTTCGGG ATATCGCCGC GCGAGGCCAC 3780 GGCCATGGAC CCGCAGCAGC GCTTGCTGCT GGAAGCGTCG TGGGAGGCCC TCGAGGACGC 3840 CGGAGTGCTC CCCGAGTCAC TGCGCGGCGG CGACGCCGGA GTGTTCGTCG GCGCCACCGC 3900 ACCGGAGTAC GGGCCGAGGC TTCACGAGGG AGCGGACGGA TACGAGGGGT ACCTGCTCAC 3960 CGGCACCACC GCGAGCGTGG CCTCCGGCCG GATCGCCTAC ACCCTCGGCA CCGGCGGACC 4020 GGCGCTCACC GTCGACACCG CGTGCTCCTC GTCCCTGGTG GCGCTGCACC TGGCCGTGCA 4080 GGCGCTGCGC CGGGGCGAGT GCGGGCTGGC TCTGGCGGGC GGCGCCACGG TGATGTCGGG 4140 GCCCGGCATG TTCGTGGAGT TCTCGCGGCA GCGCGGGCTC GCCCCCGACG GCCGCTGCAT 4200 GCCGTTCTCC GCCGATGCCG ACGGTACGGC CTGGTCCGAG GGTGTCGCCG TACTGGCACT 4260 GGAGCGGCTC TCCGACGCCC GGCGTGCGGG ACACCGGGTG CTGGGCGTGG TGCGGGGCAG 4320 TGCGGTCAAC CAGGACGGTG CCAGCAACGG CCTGACCGCT CCCAACCGCT CCGCGCAGGA 4380 GGGCGTCATC CGAGCTGCCC TGGCCGACGC CGGCCTCGCG CCGGGTGACG TGGACGCGGT 4440 GGAGGCGCAC GGTACGGGGA CGGCGCTGGG CGATCCGATC GAGGCGAGCG CGCTGCTGGC 4500 CACGTACGGG CGTGAGCGGG TGGGCGACCC CTTGTGGCTC GGGTCGCTGA AGTCCAACGT 4560 CGGTCACACC CAGGCCGCCG CGGGGGCCGC GGGTGTGGTC AAGATGCTGC TTGCCCTGGA 4620 GCACGGCACG CTGCCGCGGA CACTTCACGC GGACCGGCCC AGCACGCACG TCGACTGGTC 4680 GTCGGGCACC GTCGCCCTGC TGGCAGAGGC GCGCCGGTGG CCCCGGCGGT CGGACCGCCC 4740 GCGCCGGGCG GCTGTGTCGT CGTTCGGGAT CAGTGGGACG AACGCGCATC TGATCATCGA 4800 GGAGGCGCCG GAGTGGGTCG AGGACATCGA CGGCGTCGCT GCTCCTGACC GCGGTACCGC 4860 GGACGCGGCT GCTCCGTCGC CGCTGTTGTT GTCCGCGCGG TCGGAGGGGG CGTTGCGGGC 4920 GCAGGCGGTG CGGTTGGGTG AGTACGTGGA GCGGGTGGGT GCGGATCCGC GGGATGTGGC 4980 TTATTCGCTG GCTTCGACGC GGACTCTTTT CGAGCACCGT GCGGTGGTGC CGTGTGGTGG 5040 GCGTGGGGAG CTCGTCGCTG CTCTTGGTGG GTTTGCTGCC GGGAGGGTGT CTGGGGGTGT 5100 GCGGTCCGGG CGGGCTGTGC CGGGTGGGGT GGGGGTGTTG TTCACGGGTC AGGGTGCGCA 5160 GTGGGTTGGT ATGGGGCGTG GGTTGTATGC GGGGGGTGGG GTGTTTGCGG AGGTGCTGGA 5220 TGAGGTGTTG TCGATGGTGG GGGAGGTGGA TGGTCGGTCG TTGCGGGATG TGATGTTCGG 5280 CGACGTCGAC GTGGACGCGG GTGCCGGGGC TGATGCGGGT GCCGGTGCGG GTGCTGGGGT 5340 CGGTTCTGGT TCCGGTTCTG TGGGTGGGTT GTTGGGTCGG ACGGAGTTTG CTCAGCCTGC 5400 GCTGTTTGCG TTGGAGGTGG CGTTGTTCCG GGCGTTGGAG GCTCGGGGTG TGGAGGTGTC 5460 GGTGGTGTTG GGTCATTCGG TGGGGGAGGT GGCTGCTGCG TATGTGGCGG GGGTGTTGTC 5520 GTTGGGTGAT GCGGTGCGGT TGGTGGTGGC GCGGGGTGGG TTGATGGGTG GGTTGCCGGT 5580 GGGTGGGGGG ATGTGGTCGG TGGGGGCGTC GGAGTCGGTG GTGCGGGGGG TTGTTGAGGG 5640 GTTGGGGGAG TGGGTGTCGG TTGCGGCGGT GAATGGGCCG CGGTCGGTGG TGTTGTCGGG 5700 TGATGTGGGT GTGCTGGAGT CGGTGGTTGC CTCGCTGATG GGGGATGGGG TGGAGTGCCG 5760 GCGGTTGGAT GTGTCGCATG GGTTTCATTC GGTGTTGATG GAGCCGGTGT TGGGGGAGTT 5820 CCGGGGGGTT GTGGAGTCGT TGGAGTTCGG TCGGGTGCGG CCGGGTGTGG TGGTGGTGTC 5880 GGGTGTGTCG GGTGGGGTGG TGGGTTCGGG GGAGTTGGGG GATCCGGGGT ATTGGGTGCG 5940 TCATGCGCGG GAGGCGGTGC GTTTCGCGGA TGGGGTGGGG GTGGTGCGTG GTCTGGGTGT 6000 GGGGACGTTG GTGGAGGTGG GTCCGCATGG GGTGCTGACG GGGATGGCGG GTGAGTGCCT 6060 GGGGGCCGGT GATGATGTGG TGGTGGTGCC GGCGATGCGG CGGGGCCGTG CGGAGCGGGA 6120 GGTGTTCGAG GCGGCGCTGG CGACGGTGTT CACCCGGGAC GCCGGCCTGG ACGCCACGGC 6180 ACTCCACACC GGGAGCACCG GCCGGCGCAT CGACCTCCCC ACCTACCCCT TCCAACGCGA 6240 CCGCTACTGG CTGGACCCCG TTCGCACCGC CGTGACCGGC GTCGAGCCCG CCGGCTCGCC 6300 GGCGGACGCT CGGGCCACTG AGCGGGGACG GTCGACGACG GCCGGGATCC GCTACCGCGT 6360 CGCTTGGCAG CCGGCCGTCG TCGACCGCGG CAACCCCGGG CCTGCCGGTC ATGTGCTGCT 6420 TCTGGCCCCG GACGAGGACA CGGCCGACTC CGGACTCGCC CCCGCGATCG CACGTGAACT 6480 CGCCGTGCGC GGGGCCGAGG TCCACACCGT CGCCGTGCCG GTCGGTACAG GCCGGGAGGC 6540 AGCCGGGGAC CTGTTGCGGG CCGCCGGTGA CGGTGCCGCC CGCAGCACCC GAGTTCTGTG 6600 GCTCGCCCCG GCCGAGCCGG ACGCGGCCGA CGCCGTCGCC CTCGTCCAGG CGCTGGGCGA 6660 GGCGGTACCC GAAGCCCCGC TCTGGATCAC CACCCGTGAG GCGGCGGCCG TGCGGCCGGA 6720 CGAGACCCCT TCCGTCGGGG GCGCTCAGCT GTGGGGACTC GGACAGGTCG CCGCGCTCGA 6780 ACTGGGGCGG CGCTGGGGCG GCTTGGCGGA CCTGCCCGGG AGTGCGTCGC CCGCGGTGCT 6840 CCGTACGTTC GTCGGGGCGC TGCTCGCCGG GGGAGAGAAC CAGTTCGCGG TACGGCCCTC 6900 CGGCGTCCAT GTCCGCCGTG TGGTTCCCGC GCCCGTCCCC GTCCCGGCCT CCGCTCGCAC 6960 CGTCACCACG GCCCCCGCCA CCGCCGTCGG CGAGGACGCA CGGAACGACA CCTCGGACGT 7020 GGTCGTGCCG GACGACCGGT GGTCCTCCGG CACCGTACTG ATCACCGGGG GCACCGGTGC 7080 CCTGGGTGCG CAGGTCGCCC GCAGGCTCGC CCGGTCGGGC GCCGCGCGTC TGCTCCTGGT 7140 GGGCCGGCGC GGCGCGGCCG GCCCCGGAGT GGGCGAACTC GTCGAGGAGC TGACGGCGCT 7200 CGGTTCCGAA GTGGCCGTCG AGGCCTGCGA CGTCGCCGAC CGGGACGCAC TGGCCGCGCT 7260 CCTCGCGGGC CTCCCCGAGG AGCGGCCCCT CGTCGCCGTA CTGCACGCGG CAGGTGTGCT 7320 CGACGACGGT GTGCTCGACT CGCTCACCTC CGACCGGGTG GACGCCGTAC TGCGGGACAA 7380 GGTCACCGCC GCCCGTCACC TGGACGAGCT GACCGCGGAC CTTCCGCTCG ACGCCTTCGT 7440 GCTCTTCTCC TCCATCGTCG GCGTGTGGGG CAACGGAGGG CAGGCCGTCT ACGCGGCCGC 7500 CAACGCCGCG CTCGACGCCC TGGCGCAGCG GCGCCGGGCC AGGGGAGCCC GTGCCGCCTC 7560 GATCGCCTGG GGGCCGTGGG CCGGTGCCGG AATGGCCTCC GGAACGGCGG CGAAGTCCTT 7620 CGAACGGGAC GGCGTCACGG CCCTGGACCC CGAGCGCGCG CTCGACGTCC TCGACGACGT 7680 GGTGGGCGCC GGCGGGACCT CTGCCGCAGG GACGCACGCG GCCGGCGAGA GCTCCCTGCT 7740 CGTCGCCGAC GTGGACTGGG AGACCTTCGT CGGGCGTTCG GTCACCCGCC GTACCTGGTC 7800 GCTCTTCGAC GGCGTCTCCG CCGCCCGTTC GGCGCGTGCC GGCCATGCCG CGGACGACCG 7860 TGCCGCTCTC ACCCCAGGGA CGCGGCCGGG CGACGGCGCA CCGGGCGGGA GCGGACAGGA 7920 CGGGGGCGAG GGCCGGCCGT GGCTCTCCGT CGGCCCCTCG CCGGCGGAAC GCCGTCGTGC 7980 TCTGCTCACG CTTGTGCGCT CGGAGGCCGC CGGGATCCTG CGCCACGCCT CGGCCGACGC 8040 GGTCGACCCG GAGCTGGCCT TCCGGTCCGC CGGGTTCGAC TCCCTCACCG TTCTCGAACT 8100 GCGTAACCGC CTGACCGCTG CCACCGGCCT GAACCTGCCG AACACGCTGC TCTTCGACCA 8160 CCCGACCCCC CTCTCGCTCG CCTCCCACCT GCACGACGAA CTGTTCGGTC CCGACAGCGA 8220 GGCGGAGCCG GCAGCGGCCG CCCCCACGCC GGTCATGGCC GACGAGCGTG AGCCGATCGC 8280 GATCGTGGGC ATGGCGTGCC GTTACCCGGG CGGTGTGGCG TCGCCGGACG ACCTGTGGGA 8340 CCTGGTGGCC GGTGACGGGC ACACGCTCTC CCCGTTCCCG GCCGACCGTG GCTGGGACGT 8400 CGAGGGGCTG TACGACCCGG AGCCGGGGGT GCCGGGCAAG AGCTATGTAC GGGAAGGCGG 8460 GTTCCTGCGT TCCGCGGCCG AGTTCGACGC GGAGTTCTTC GGGATATCGC CGCGCGAGGC 8520 CACGGCCATG GACCCGCAGC AGCGGTTGCT GCTGGAGACG TCGTGGGAGG CGCTGGAGCG 8580 GGCCGGCATC GTTCCGGACT CGCTGCGCGG CACCCGGACC GGTGTCTTCA GCGGCATCTC 8640 CCAGCAGGAC TACGCGACCC AGCTGGGGGA CGCCGCCGAC ACCTACGGCG GGCATGTGCT 8700 CACGGGGACC CTCGGCAGTG TGATCTCCGG TCGGGTTGCC TATGCGTTGG GGTTGGAGGG 8760 GCCGGCGCTG ACGGTGGACA CGGCGTGTTC GTCGTCGTTG GTGGCGTTGC ATCTGGCGGT 8820 GCAGTCGTTG CGGCGGGGTG AGTGTGATCT GGCGTTGGCC GGTGGGGTGA CGGTGATGGC 8880 GACGCCGACG GTGTTCGTGG AGTTCTCGCG GCAGCGGGGG CTGGCGGCGG ACGGGCGGTG 8940 CAAGGCGTTC GCGGAGGGTG CGGACGGGAC GGCGTGGGCG GAGGGTGTGG GTGTGCTGCT 9000 GGTGGAGCGG CTTTCCGACG CGCGCCGCAA CGGTCATCGG GTGCTGGCGG TGGTGCGGGG 9060 CAGTGCGGTC AATCAGGACG GTGCGAGCAA TGGGCTGACG GCGCCGAGTG GTCCGGCGCA 9120 GCAGCGGGTG ATCCGTGAGG CGCTGGCTGA TGCGGGGCTG GTGCCCGCCG ACGTGGATGT 9180 GGTGGAGGCG CACGGTACGG GGACGGCGCT GGGTGATCCG ATCGAGGCGG GTGCGCTGCT 9240 GGCCACGTAC GGGCGGGAGC GGGTCGGCGA TCCGTTGTGG CTCGGGTCGT TGAAGTCGAA 9300 CATCGGGCAT GCGCAGGCGG CTGCGGGTGT GGGTGGTGTG ATCAAGGTGG TGCAGGGGAT 9360 GCGGCATGGG TCGTTGCCGC GGACGCTGCA TGTGGATGCG CCGTCGTCGA AGGTGGAGTG 9420 GGCTTCGGGT GCGGTGGAGC TGCTGACCGA GACCCGGTCG TGGCCGCGGC GGGTGGAGCG 9480 GGTGCGGCGG GCCGCGGTGT CGGCGTTCGG GGTGAGCGGG ACCAACGCCC ATGTGGTCCT 9540 GGAGGAAGCG CCGGCGGAGG CCGGGAGCGA GCACGGGGAC GGCCCTGAAC CTGAGCGGCC 9600 CGACGCGGTG ACGGGTCCGT TGTCGTGGGT GCTTTCTGCG CGGTCGGAGG GGGCGTTGCG 9660 GGCGCAGGCG GTGCGGTTGC GTGAGTGTGT GGAGCGGGTG GGTGCGGATC CGCGGGATGT 9720 GGCGGGGTCG TTGGTGGTGT CGCGTGCGTC GTTCGGTGAG CGTGCGGTGG TGGTGGGCCG 9780 GGGGCGTGAG GAGTTGCTGG CGGGTCTGGA TGTGGTGGCT GCCGGGGCTC CTGTGGGTGT 9840 GTCTTCGGGG GCCGGTGCTG TGGTGCGGGG GAGTGCGGTG CGGGGTCGTG GGGTGGGGGT 9900 GTTGTTCACG GGTCAGGGTG CGCAGTGGGT TGGTATGGGG CGTGGGTTGT ATGCGGGGGG 9960 TGGGGTGTTT GCGGAGGTGC TGGATGAGGT GTTGTCGGTG GTGGGGGAGG TGGATGGTCG 10020 GTCGTTGCGG GATGTGATGT TCGCGGATGC TGACTCGGTT TTGGGTGGGT TGTTGGGTCG 10080 GACGGAGTTT GCTCAGCCTG CGTTGTTTGC GTTGGAGGTG GCGTTGTTCC GGGCGTTGGA 10140 GGCTCGGGGT GTGGAGGTGT CGGTGGTGTT GGGTCATTCG GTGGGGGAGG TGGCTGCTGC 10200 GTATGTGGCG GGGGTGTTGT CGTTGGGTGA TGCGGTGCGG TTGGTGGTGG CGCGGGGTGG 10260 GTTGATGGGT GGGTTGCCGG TGGGTGGGGG GATGTGGTCG GTGGGGGCGT CGGAGTCGGT 10320 GGTGCGGGGG GTTGTTGAGG GGTTGGGGGA GTGGGTGTCG GTTGCGGCGG TGAATGGGCC 10380 GCGGTCGGTG GTGTTGTCGG GTGATGTGGG TGTGCTGGAG TCGGTGGTTG TCACGCTGAT 10440 GGGGGATGGG GTGGAGTGCC GGCGGTTGGA TGTGTCGCAT GGGTTTCATT CGGTGTTGAT 10500 GGAGCCGGTG TTGGGGGAGT TCCGGGGGGT TGTGGAGTCG TTGGAGTTCG GTCGGGTGCG 10560 GCCGGGTGTG GTGGTGGTGT CGGGTGTGTC GGGTGGGGTG GTGGGTTCGG GGGAGTTGGG 10620 GGATCCGGGG TATTGGGTGC GTCATGCGCG GGAGGCGGTG CGTTTCGCGG ATGGGGTGGG 10680 GGTGGTGCGT GGTCTGGGTG TGGGGACGTT GGTGGAGGTG GGTCCGCATG GGGTGCTGAC 10740 GGGGATGGCG GGTCAGTGCC TGGAGGCCGG TGATGATGTG GTGGTGGTGC CGGCGATGCG 10800 GCGGGGCCGT CCGGAGCGGG AGGTGTTCGA GGCGGCGCTG GCGACGGTGT TCACCCGGGA 10860 CGCCGGCCTC GACGCCACGA CACTCCACAC CGGGAGCACC GGCCGACGCA TCGACCTCCC 10920 CACCTACCCC TTCCAACACA ACCGCTACTG GGCAACCGGC TCAGTGACCG GTGCGACCGG 10980 CACCTCGGCA GCCGCGCGCT TCGGCCTGGA GTGGAAGGAC CACCCCTTCC TCAGCGGCGC 11040 CACGCCGATA GCCGGCTCCG GCGCGCTGCT CCTCACCGGC AGGGTGGGGC TCGCTGCCCA 11100 CCCGTGGCTG GCCGACCACG CCATCTCCGG CACGGTGCTG CTCCCCGGAA CGGCGATCGC 11160 CGACCTGCTG CTGCGGGCGG TCGAGGAGGT CGGCGCCGGA GGGGTCGAGG AACTGACGCT 11220 CCATGAGCCC CTGCTCCTCC CCGAGCGAGG CGGCCTGCAC GTCCAGGTGC TGGTCGAGGC 11280 GGCCGACGAG CAGGGACGGC GTGCCGTGGC AGTCGCCGCA CGCCCGGAGG GCCCTGGGCG 11340 GGACGGTGAG GAACAGGAGT GGACCCGGCA CGCGGAAGGC GTGCTCACCT CCACCGAGAC 11400 GGCCGTTCCG GACATGGGCT GGGCCGCCGG GGCCTGGCCG CCGCCCGGTG CCGAGCCGAT 11460 CGACGTCGAG GAGCTGTACG ACGCGTTCGC CGCGGACGGC TACGGCTACG GCCCGGCCTT 11520 CACCGCACTG TCCGGCGTGT GGCGTCTCGG CGACGAACTC TTCGCCGAGG TGCGGCGGCC 11580 CGCGGGGGGC GCGGGCACGA CCGGTGACGG TTTCGGCGTC CACCCCGCAC TCTTCGATGC 11640 GGCCCTCCAC CCGTGGCGCG CCGGCGGGCT GCTGCCCGAC ACGGGCGGCA CCACCTGGGC 11700 GCCGTTCTCC TGGCAGGGCA TCGCGCTCCA CACCACCGGA GCCGAGACGC TCCGCGTCAG 11760 ACTGGCCCCT GCGGCCGGCG GCACCGAGTC GGCCTTCTCC GTACAGGCCG CCGACCCGGC 11820 GGGCACCCCG GTCCTCACCC TCGACGCACT GCTGCTCCGC CCGGTGACCC TGGGGAGGGC 11880 CGACGCGCCG CAACCGCTGT ACCGCGTCGA CTGGCAGCCG GTCGGCCAGG GGACCGAGGC 11940 CTCCGGCGCC CAGGGCTGGA CGGTGCTCGG GCAGGCCGCG GCCGAGACGG TCGCGCAGCC 12000 CGCCGCCCAT GCGGACCTCA CCGCCCTGCG TACGGCTGTG GCCGCGGCGG GAACACCCGT 12060 GCCCCGGCTG GTGGTCGTGT CGCCGGTGGA CACCCGGCTG GACGAGGGGC CGGTGCTGGC 12120 GGACGCCGAG GCTCGGGCCC GTGCGGGTGA CGGCTGGGAC GACGATCCCC TACGTGTCGC 12180 CCTCGGGCGC GGCCTGACCC TGGTCCGGGA GTGGGTCGAG GACGAACGGT TGGCGGACTC 12240 CCGGCTCGTC GTCCTCACCC GTGGCGCGGT GGCGGCCGGT CCCGGCGATG TGCCGGACCT 12300 GACAGGTGCG GCCCTGTGGG GGCTGCTCCG CTCCGCGCAG TCGGAGTATC CGGACCGCTT 12360 CACCCTCATC GACGTGGACG ATTCCCCCGA GTCCCGTGCG GCTCTGCCCC GGGCTCTGGG 12420 ATCGGCCGAG CGACAACTCG CCCTGCGGAC GGGCGACGTG CTGGCGCCGG CCCTGGTCCC 12480 GATGGCCACC CGGCCGGCGG AGACCACTCC AGCGACGGCG GTCGCCTCGG CGACAACACA 12540 GACACAGGTC ACCGCGCCCG CTCCCGACGA CCCGGCTGCG GATGCCGTGT TCGACCCGGC 12600 GGGCACCGTA CTGATCACCG GCGGCACCGG CGCCCTGGGA CGGCGTGTCG CCTCGCACCT 12660 CGCGCGCCGG TACGGCGTAC GCCACATGCT TCTGGTCAGC AGGCGTGGAC CGGACGCCCC 12720 CGAGGCCGGT CCCCTGGAAC GGGAACTCGC CGGTCTCGGA GTCACCGCCA CCTTCCTGGC 12780 ATGCGACCTC ACCGACATCG AGGCCGTACG GAAGGCCGTC GCCGCGGTGC CGTCGGACCA 12840 CCCGCTGACC GGTGTGGTGC ACACCGCCGG CGTGCTGGAC GACGGCGCCC TGACCGGCCT 12900 GACCCGGCAA CGCCTCGACA CCGTGCTGCG GCCCAAGGCC GACGCCGTGC GGAACCTCCA 12960 CGAGGCGACC CTCGACCGGC CGCTGCGCGC GTTCGTCCTG TTCTCCGCCG CCGCCGGACT 13020 CCTGGGCCGC CCCGGGCAGG CCTCCTACGC CGCCGCCAAC GCGGTCCTCG ACGCGCTCGC 13080 GGGAGCCCGC CGCGCGGCCG GACTGCCCGC AGTGTCCCTG GCGTGGGGCC TGTGGGACGA 13140 GCAGACGGGC ATGGCAGGAG GCCTCGACGA GATGGCCCTG CGCGTGCTGC GCCGGGACGG 13200 CATCGCCGCG ATGCCTCCGG AGCAGGGGCT CGAACTGCTC GACCTGGCCC TGACCGGACA 13260 CCGGGACGGA CCCGCCGTCC TCGTCCCCCT CCTCCTCGAC GGCGCGGCCC TGCGCCGCAC 13320 GGCGAAGGAG CGCGGCGCGG CCACGATGTC CCCCTTGCTG CGCGCCCTGC TGCCCGCCGC 13380 CCTGCGCCGC AGCGGTGGAG CCGGCGCCCC CGCGGCGGCC GACCGGCACG GCAAGGAGGC 13440 GGACCCCGGT GCGGGACGCC TCGCAGGGAT GGTGGCACTC GAAGCGGCGG AGCGTTCCGC 13500 GGCCGTCCTT GAGCTGGTCA CCGAACAGGT CGCCGAGGTC CTCGGCTACG CGTCGGCCGC 13560 GGAGATCGAG CCCGAACGAC CCTTCCGGGA GATCGGCGTC GACTCCCTGG CGGCGGTGGA 13620 GCTGCGCAAC CGGCTCAGCC GTCTGGTCGG CCTGCGGTTG CCGACCACGC TGTCCTTCGA 13680 CCACCCCACG CCGAAGGACA TGGCGCAGCA CATCGACGGG CAGCTCCCCC GCCCGGCCGG 13740 AGCCTCGCCC GCGGACGCAG CGCTGGAAGG GATCGGCGAC CTCGCGCGGG CGGTCGCCCT 13800 GCTGGGCACG GGCGACGCCC GCCGGGCCGA GGTACGAGAG CAGCTCGTCG GACTGCTGGC 13860 CGCGCTCGAC CCACCTGGGC GGACGGGCAC CGCCGCACCC GGCGTCCCCT CCGGTGCCGA 13920 TGGCGCGGAA CCGACCGTGA CGGACCGGCT CGACGAGGCG ACCGACGACG AGATCTTCGC 13980 CTTCCTGGAC GAGCAGCTGT GACCACACCG TGGACCGACC GCATGCCGAG GAGTTGGTGG 14040 CAGCAATGAC CGCCGAGAAC GACAAGATCC GCAGCTACCT GAAGCGTGCC ACCGCCGAAC 14100 TGCACCGGAC CAAGTCCCGC CTGGCCGAGG TCGAGTCGGC GAGCCGCGAG CCGATCGCGA 14160 TCGTGGGCAT GGCGTGCCGT TACCCGGGCG GTGTGGCGTC GCCGGACGAC CTGTGGGACC 14220 TGGTGGCAGC CGGTACGGAC GCGGTCTCCG CGTTCCCCGT CGACCGTGGC TGGGACGTCG 14280 AGGGGCTGTA CGACCCCGAT CCGGAGGCGG TGGGGCGTAG TTACGTGCGG GAGGGCGGGT 14340 TCCTGCACTC GGCGGCCGAG TTCGACGCGG AGTTCTTCGG GATCTCGCCC CGTGAGGCGG 14400 CGGCGATGGA TCCGCAGCAG CGGTTGCTGC TGGAGACGTC GTGGGAGGCG CTGGAGCGGG 14460 CGGGGATCGT CCCCGCGTCG CTGCGCGGCA CCCGTACCGG CGTCTTCACC GGCGTCATGT 14520 ACGACGACTA CGGGTCGCGG TTCGACTCGG CTCCGCCGGA GTACGAGGGC TACCTCGTGA 14580 ACGGCAGCGC CGGCAGCATC GCGTCCGGTC GGGTTGCCTA TGCGTTGGGG TTGGAGGGGC 14640 CGGCGCTGAC GGTGGACACG GCGTGTTCGT CGTCGTTGGT GGCGTTGCAT CTGGCGGTGC 14700 AGTCGTTGCG GCGGGGTGAG TGTGATCTGG CGTTGGCCGG TGGGGTGACG GTGATGGCGA 14760 CGCCGACGGT GCTCGTGGAG TTCTCGCGGC AGCGGGGGCT GGCGGCGGAC GGGCGGTGCA 14820 AGGCGTTCGC GGAGGGTGCG GACGGGACGG CGTGGGCCGA GGGTGTGGGC GTGCTGCTGG 14880 TGGAGCGGCT CTCCGACGCC CGCCGCAATG GCCATCGGGT GCTGGCGGTG GTGCGGGGCA 14940 GTGCGGTCAA TCAGGACGGT GCGAGCAACG GGCTGACGGC GCCGAGTGGT CCTGCGCAGC 15000 AGCGGGTGAT CCGTGAGGCG CTGGCCGACG CGGGGCTGAC GCCCGCCGAC GTCGACGCGG 15060 TCGAGGCGCA CGGCACCGGC ACACCCCTGG GCGACCCCAT CGAGGCGGGT GCGTTGCTGG 15120 CCACCTATGG CAGTGAGCGC CAGGGCCAAG GTCCGTTGTG GTTGGGGTCG TTGAAGTCGA 15180 ACATCGGGCA TGCGCAGGCG GCTGCGGGTG TGGGTGGCGT GATCAAGGTG GTGCAGGCGA 15240 TGCGGCATGG GTCGTTGCCG CGGACGCTGC ATGTGGATGC GCCGTCGTCG AAGGTGGAGT 15300 GGGCTTCGGG TGCGGTGGAG CTGCTGACCG AGACCCGGTC GTGGCCGCGG CGGGTGGAGC 15360 GGGTGCGGCG GGCCGCGGTG TCGGCGTTCG GGGTGAGCGG GACCAACGCC CATGTGGTCC 15420 TGGAGGAAGC GCCGGCGGAG GCCGGGAGCG AGCACGGGGA CGGCCCTGAA CCCGAGCGGC 15480 CCGACGCGGT GACGGGTCCG TTGTCGTGGG TGCTTTCTGC GCGGTCGGAG GGGGCGTTGC 15540 GGGCGCAGGC GGTGCGGTTG CGTGAGTGTG TGGAGCGGGT GGGTGCGGAT CCGCGGGATG 15600 TGGCGGGGTC GTTGGTGGTG TCGCGTGCGT CGTTCGGTGA GCGTGCGGTG GTGGTGGGCC 15660 GGGGGCGTGA GGAGTTGCTG GCGGGTCTGG ATGTGGTGGC TGCCGGGGCT CCTGTGGGTG 15720 TGTCCGGGGG CGTGTCTTCG GGGGCCGGTG CTGTGGTGCG GGGGAGTGCG GTGCGGGGTC 15780 GTGGGGTGGG GGTGTTGTTC ACGGGTCAGG GTGCGCAGTG GGTTGGTATG GGGCGTGGGT 15840 TGTATGCGGG GGGTGGGGTG TTTGCGGAGG TGCTGGATGA GGTGTTGTCG GTGGTGGGGG 15900 AGGTGGGGGG TTGGTCGTTG CGGGATGTGA TGTTCGGCGA CGTCGACGTG GACGCGGGTG 15960 CCGGGGCTGA TGCGGGTGTC GGTTCGGGTG TTGGTGTGGG TGGGTTGTTG GGTCGGACGG 16020 AGTTTGCTCA GCCTGCGTTG TTTGCGTTGG AGGTGGCGTT GTTCCGGGCG TTGGAGGCTC 16080 GGGGTGTGGA GGTGTCGGTG GTGTTGGGTC ATTCGGTGGG GGAGGTGGCT GCTGCGTATG 16140 TGGCGGGGGT GTTGTCGTTG GGTGATGCGG TGCGGTTGGT GGTGGCGCGG GGTGGGTTGA 16200 TGGGTGGGTT GCCGGTGGGT GGGGGGATGT GGTCGGTGGG GGCGTCGGAG TCGGTGGTGC 16260 GGGGGGTTGT TGAGGGGTTG GGGGAGTGGG TGTCGGTTGC GGCGGTGAAT GGGCCGCGGT 16320 CGGTGGTGTT GTCGGGTGAT GTGGGTGTGC TGGAGTCGGT GGTTGCCTCG CTGATGGGGG 16380 ATGGGGTGGA GTGCCGGCGG TTGGATGTGT CGCATGGGTT TCATTCGGTG TTGATGGAGC 16440 CGGTGTTGGG GGAGTTCCGG GGGGTTGTGG AGTCGTTGGA GTTCGGTCGG GTGCGGCCGG 16500 GTGTGGTGGT GGTGTCGAGT GTGTCGGGTG GGGTGGTGGG TTCGGGGGAG TTGGGGGATC 16560 CGGGGTATTG GGTGCGTCAT GCGCGGGAGG CGGTGCGTTT CGCGGATGGG GTGGGGGTGG 16620 TGCGTGGTCT GGGTGTGGGG ACGTTGGTGG AGGTGGGTCC GCATGGGGTG CTGACGGGGA 16680 TGGCGGGTGA GTGCCTGGGG GCCGGTGATG ATGTGGTGGT GGTGCCGGCG ATGCGGCGGG 16740 GCCGTGCGGA GCGGGAGGTG TTCGAGGCGG CGCTGGCGAC GGTGTTCACC CGGGACGCCG 16800 GCCTGGACGC CACGACACTC CACACCGGGA GCACCGGCCG ACGCATCGAC CTCCCCACCT 16860 ACCCCTTCCA ACACGACCGC TACTGGCTGG CCGCCCCGTC CCGGCCCAGG ACGGACGGGC 16920 TGTCGGCGGC GGGTCTGCGC GAGGTGGAGC ACCCCCTGCT CACCGCCGCC GTGGAACTGC 16980 CCGGCACCGA CACCGAGGTG TGGACCGGCC GCATATCCGC TGCCGACCTG CCCTGGCTCG 17040 CCGACCACCT GGTGTGGGAC CGAGGCGTGG TGCCGGGGAC CGCGCTGCTG GAGACGGTGC 17100 TCCAGGTGGG AAGCCGGATC GGTCTGCCGC GCGTCGCCGA ACTGGTCCTG GAGACGCCGC 17160 TGACCTGGAC GTCGGACCGC CCGCTCCAGG TCCGGATCGT CGTGACCGCT GCCGCCACCG 17220 CCCCCGGGGG CGCGCGTGAG CTGACCCTCC ACTCGCGGCC CGAGCCCGTG GCCGCCTCCT 17280 CGTCCTCCCC GAGTCCCGCC TCTCCCCGGC ACCTCACGGC GCAGGAGAGC GACGACGACT 17340 GGACCCGGCA TGCCTCAGGG CTGCTCGCCC CGGCTGCCGG CCTCGCCGAC GACTTCGCCG 17400 AGCTCACCGG CGCCTGGCCC CCCGTCGGCG CCGAGCCCCT CGACCTCGCC GGTCAGTACC 17460 CGCTCTTCGC AGCCGCCGGA GTGCGCTACG AAGGCGCCTT CCGAGGGCTG CGCGCGGCAT 17520 GGCGTCGAGG CGACGAGGTC TTCGCCGACG TACGGCTGCC CGACGCGCAC GCGGTCGACG 17580 CTGATCGTTA CGGGGTGCAC CCCGCCCTGC TCGACGCGGT GCTCCACCCG ATCGCGTCGC 17640 TGGACCCGCT GGGCGACGGC GGGCACGGTC TGCTGCCGTT CTCCTGGACC GACGTACAGG 17700 GACACGGCGC CGGCGGACAC GCCCTCCGGG TACGGGTGGC GGCCGTCGAC GGCGGCGCGG 17760 TGTCGGTCAC CGCGGCCGAC CACGCGGGCA ACCCGGTGTT ATCCGCCCGG TCCCTGGCAC 17820 TGCGTCGTAT CACCGCGGAC CGGCTTCCCG CCGCGCCCGT CGCCCCTCTC TACCGCGTGG 17880 ACTGGCTGCC GTTCCCGGGT CCGGTGCCCG TATCCGCGGG CGGCCGCTGG GCGGTCGTCG 17940 GACCCGAGGC CGAAGCCACG GCTGCCGGAC TGCGTGCGGT GGGCCTCGAC GTGCGTACCC 18000 ATGCGCTCCC CCTCGGAGAG CCCCTGCCTC CGCAGGCCGG TACCGACGCG GAGGTGATCA 18060 TCCTCGACCT GACCACCACC GCAGCCGGCC GTACGGCGTC GGACGGGGGG CGGCTCAGTC 18120 TCCTCGACGA GGTGCGTGCG ACGGTGCGCC GGACCCTCGA AGCCGTACAG GCCCGCCTCG 18180 CCGACACCGA AACGGCCCCC GACGTCGACG TCCGTACGGC CGCGCGCCCC CGCACAGCCG 18240 CCCGTACAAG CCCCCGCGTG GACACCCGCA CGGGAGCCCG CACCGCTGAC GGCCCCCGGC 18300 TCGTCGTCCT GACCCGGGGC GCGGCCGGAC CCGAGGGAGG CGCGGCCGAT CCCGCGGGTG 18360 CCGCTGTCTG GGGGCTCGTC CGGGTCGCCC AGGCCGAACA GCCCGGCCGC TTCACCCTGG 18420 TGGACGTCGA CGGCACCCAG GCGTCGCTGC GGGCCCTGCC CGGTCTGCTG GCCACGGATG 18480 CCGGCCAGTC GGCCGTGCGC GACGGACGTG TCACCGTCCC GCGCCTCGTC CCGGTGGCCG 18540 ACCCCGTCCC CCACGGCGGC GGCACGGCGG CCGACGGGAC GGGTGCCGGC GAGCCGTCCG 18600 CGACCCTGGA CCCCGAAGGC ACCGTGCTGA TCACCGGCGG CACCGGAGCA CTGGCCGCGG 18660 3AAACCGCCCG GCACCTGGTC GACCGGCACA AGGTGCGCCA TCTCCTGCTG GTGGGCAGG 18720 GCGGTCCCGA CGCACCCGGC GTCGATCGAC TGGTCGCCGA GTTGACCGAG TCGGGTGCCG 18780 AGGTCGCCGT ACGGGCCTGT GACGTCACGG ACCGCGACGC CCTGCGCCGC CTGCTCGACG 18840 CACTCCCCGA CGAACACCCG CTGACCTGCG TGGTGCACAC CGCCGGGGTG CTCGACGACG 18900 GCGTGCTCTC CGCCCAGACG GCCGAGCGGA TCGACACGGT GCTCCGGCCC AAGGCCGACG 18960 CCGCCGTCCA CCTGGACGAG CTGACCCGGG AGATCGGACG GGTGCCCCTG GTGCTGTACT 19020 CCTCGGTCTC GGCCACCCTG GGCAGCGCGG GGCAGGCCGG GTACGCGGCG GCCAACGCCT 19080 TCATGGACGC GCTGGCCGCC CGGCGGTGCG CCGCCGGGCA CCCCGCGCTG TCGCTCGGCT 19140 GGGGCTGGTG GTCCGGGGTG GGTCTCGCCA CCGGACTGGA CGGAGCGGAC GCGGCGCGGG 19200 TCAGGCGCTC GGGTCTCGCC CCGCTCGACG CCGGCGCCGC ACTGGACCTG CTCGACCGGG 19260 CGCTGACCCG GCCCGAGCCG GCCCTGCTGC CCGTGCGGCT CGACCTGCGC GCCGCGGCCG 19320 GTGCCACCGC TCTCCCGGAG GTCCTGCGTG ACCTGGCCGG CGTACCGGCG GACGCCCGCA 19380 GCACGCCCGG GGCCGCGGCG GGCACCGGGG ACGAGGACGG TGCCGTGCGC CCTGCCCCCG 19440 CCCCGGCCGA CGCCGCCGGG ACGCTGGCCG CGCGGCTCGC GGGACGTTCC GCACCCGAGC 19500 GTACGGCTCT CCTGCTCGAC CTGGTGCGGA CCGAGGTCGC GGCGGTGCTC GGACACGGCG 19560 ACCCCGCCGC GATCGGCGCC GCCCGCACCT TCAAGGACGC CGGATTCGAC TCCCTCACCG 19620 CTGTCGACCT CCGCAACCGG CTGAACACAC GCACCGGACT GCGGCTGCCC GCGACCCTCG 19680 TCTTCGACCA CCCCACACCG CTCGCCCTCG CCGAACTCCT GCTCGACGGG CTGGAGGCGG 19740 CCGGTCCAGC GGAACCGGCC GCTGAGGTCC CGGACGAAGC GGCCGGTGCC GAGACCCTGT 19800 CCGGCGTGAT CGACCGGCTG GAACGCAGCC TCGCCGCGAC CGACGACGGC GACGCCCGGG 19860 TCCGCGCGGC ACGGCGGCTG CGCGGCCTGC TGGACGCGCT CCCCGCCGGT CCCGGTGCCG 19920 CGTCCGGTCC GGATGCCGGA GAGCACGCCC CCGGTCGCGG CGACGTGGTG ATCGACCGGC 19980 TCAGGTCGGC CTCCGACGAC GACTTGTTCG ACCTGCTCGA CAGCGACTTC CAGTGAGCCG 20040 GACCGCGCCG CGCGCCGACC GCTGAACCGC TCTTCACCCA GACCCACGAG ACCACGCCTG 20100 AGGAGAACCG TGTCTGCGAC CAACGAGGAG AAGTTGCGGG AGTACCTGCG GCGCGCGATG 20160 GCCGACCTGC ACAGCGCACG AGAGCGGTTG CGCGAGGTCG AGTCGGCGAG CCGTGAGCCG 20220 ATCGCGATCG TGGGCATGGC GTGCCGTTAC CCGGGCGGTG TGGCGTCGCC GGAGGAGCTG 20280 TGGGACCTGG TGGCCGCCGG TACGGACGCG ATCTCCCCGT TCCCCGTCGA CCGCGGCTGG 20340 GACGCCGAGG GTCTGTACGA CCCGGAGCCG GGGGTGCCGG GCAAGAGCTA CGTGCGCGAG 20400 GGCGGGTTCC TGCACTCGGC GGCCGAGTTC GACGCGGAGT TCTTCGGGAT CTCGCCGCGT 20460 GAGGCGGCGG CGATGGATCC GCAGCAGCGG TTGCTGCTGG AGACGTCGTG GGAGGCGCTG 20520 GAGCGGGCCG GGATCGTCCC CGCGTCGCTG CGCGGCACCC GTACCGGCGT CTTCACCGGC 20580 GTCATGTACC ACGACTACGG CAGCCACCAG GTCGGCACCG CCGCCGATCC CAGTGGACAG 20640 CTCGGCCTCG GCACCGCGGG GAGCGTCGCC TCGGGCCGGG TGGCGTACAC CCTCGGTCTA 20700 CAGGGGCCGG CCGTGACCAT GGACACGGCA TGCTCGTCCT CGCTGGTGGC GTTGCACCTG 20760 GCGGTGCAGT CGTTGCGGCG GGGCGAGTGC GATCTCGCGT TGGCCGGCGG GGCGACGGTC 20820 TTGGCGACGC CCACGGTGTT CGTGGAGTTC TCGCGGCAAC GGGGGCTGGC GGCGGACGGA 20880 CGGTGCAAGG CGTTCGCGGA GGGCGCCGAC GGCACGGCGT GGGCCGAGGG CGCCGGTGTG 20940 CTGCTGGTGG AGCGGCTCTC CGACGCCCGC CGCAACGGCC ATCGGGTGCT CGCGGTGGTG 21000 CGGGGCAGCG CGGTCAACCA GGACGGTGCC AGCAACGGCC TCACCGCACC CAGCGGGCCC 21060 GCCCAGCAGC GGGTGATCCG TGACGCGCTG GCCGACGCGG GGCTGACGCC CGCCGACGTG 21120 GACGCGGTCG AGGCGCACGG CACCGGCACA CCGCTCGGCG ACCCGATCGA GGCCGGCGCG 21180 CTGATGGCCA CCTACGGCAG TGAACGGGTG GGCGACCCGC TGTGGCTGGG TTCGCTGAAG 21240 TCGAACATCG GACACACCCA GGCCGCCGCC GGAGCCGCCG GCGTCATCAA GATGGTGCAG 21300 GCGTTACGGC AGTCCGAGCT GCCGCGCACC CTGCACGTCG ACGCGCCCTC GGCCAAGGTC 21360 GAATGGGACG CGGGCGCCGT GCAACTGCTC ACCGGCGTCC GGCCATGGCC CCGGCGCGAG 21420 CACAGGCCCC GGCGGGCCGC GGTCTCCGCC TTCGGCGTCA GCGGCACCAA CGCCCACGTC 21480 ATCATCGAGG AACCGCCCGC GGCCGGTGAC ACCTCGCCCG CCGGCGACAC CCCTGAGCCG 21540 GGCGAGGCGA CCGCGTCCCC CTCCACCGCG GCCGGGCCGT CGTCCCCCTC CGCGGTGGCC 21600 GGGCCGCTGT CCCCCTCCTC CCCGGCCGTG GTCTGGCCCC TGTCCGCCGA GACCGCCCCC 21660 GCCCTGCGCG CCCAGGCCGC CCGCCTGCGG GCGCACCTCG AACGCCTCCC CGGCACCTCG 21720 CCGACCGACA TCGGCCACGC CCTGGCCGCC GAACGCGCCG CCCTCACCCG ACGCGTCGTG 21780 CTGCTCGGCG ACGACGGAGC CCCGGTCGAC GCACTCGCCG CCCTCGCCGC CGGCGAGACC 21840 ACCCCCGACG CCGTCCACGG CACCGCGGCG GACATCCGCC GGGTCGCCTT CGTGTTCCCC 21900 GGCCAGGGTT CCCAGTGGGC CGGGATGGGC GCCGAACTGC TGGACACGGC CCCGGCCTTC 21960 GCCGCCGAAC TGGACCGCTG CCAGGGCGCG CTCTCCCCGT ACGTGGACTG GAACCTCGCG 22020 GACGTGCTGC GCGGCGCGCC CGCGGCGCCC GGCCTCGACC GGGTCGACGT CGTCCAGCCG 22080 GCCACCTTCG CCGTCATGGT GGGACTCGCC GCGCTGTGGC GCTCCCTCGG GGTCGAACCC 22140 GCCGCCGTCA TCGGCCACTC CCAGGGCGAG ATCGCCGCGG CCTGCGTGGC GGGCGCGCTC 22200 TCCCTGGAGG ACGCCGCCCG GATCGTGGCC CTGCGCTCCC AGGTCATCGC CCGCGAACTG 22260 GCCGGGCGGG GCGGCATGGC CTCGGTGGCC CTGCCCGCGG CGGAGGTCGA GGCCCGCCTG 22320 GCCGGCGGCG TCGAGATCGC CGCCGTCAAC GGCCCCGGCT CGACCGTCGT CTGCGGAGAG 22380 CCCGGCGCCC TGGAGGCGTT GCTCGTCACG CTGGAGAGCG AAGGCACCCG GGTCCGCCGC 22440 ATCGACGTCG ACTACGCGTC CCACTCCCAC TACGTCGAGA GCATCCGGGC GGAACTCGCC 22500 ACCGTCCTCG GCCCCGTCCG GCCGCGGAGG GGCGACGTGC CCTTCTACTC CACCGTCGAG 22560 GCGGCGCTCC TCGACACCGC CACCCTGGAC GCCGACTACT GGTACCGCAA CCTGCGCCTC 22620 CCGGTGCGCT TCGAGCCGAC CGTACGCGCC ATGCTCGACG ACGGCGTCGA CGCGTTCGTG 22680 GAGTGCTCCG CGCATCCCGT CCTGACCGTC GGCGTGCGCC AGACCGTGGA GAGCGCCGGC 22740 GGCGCGGTCC CGGCCCTCGC TTCGCTGCGC CGCGACGAGG GCGGGCTGCG GCGCTTCCTC 22800 ACCTCCGCCG CCGAGGCCCA GGTCGTCGGC GTCCCCGTGG ACTGGGCGAC GCTCCGCCCA 22860 GGCGCCGGCC GGGTGGACCT GCCGACCTAC GCCTTCCAGC GCGAACGCCA CTGGGTCGGC 22920 CCCGCCCGGC CCGACTCCGC GGCGACGGCC GCCACGACCG GTGACGACGC CCCGGAGCCC 22980 GGAGACCGGC TCGGCTACCA CGTCGCGTGG AAGGGACTGC GCTCCACCAC CGGCGGCTGG 23040 CGCCCCGGCC TGCGCCTGCT GATCGTGCCC ACCGGGGACC AGTACACCGC CCTCGCCGAC 23100 ACCCTGGAAC AGGCGGTCGC CTCCTTCGGC GGAACGGTCC GCCGCGTCGC CTTCGACCCG 23160 GCACGCACCG GACGCGCCGA GCTGTTCGGC CTGCTCGAGA CGGAGATCAA CGGCGACACC 23220 GCCGTCACCG GCGTCGTCTC GCTGCTCGGA CTGTGCACCG ACGGCAGGCC GGACCACCCC 23280 GCCGTGCCCG TCGCCGTCAC CGCCACCCTC GCCCTCGTCC AGGCCCTGGC CGACCTCGGC 23340 AGCACCGCAC CGCTGTGGAC CGTCACCTGC GGCGCGGTCG CCACCGCCCC CGACGAACTG 23400 CCGTGCACCG CCGGTGCCCA GCTGTGGGGC CTGGGCCGGG TGGCCGCGCT GGAGCTGCCC 23460 GAGGTGTGGG GCGGCCTCAT CGACCTTCCC GCGCGGCCCG ACGCCCGGGT CCTGGACCGT 23520 CTCGCCGGCG TCCTCGCCGA ACCCGGCGGC GAGGACCAGA TCGCCGTACG GATGGCGGGC 23580 GTCTTCGGCC GCCGGGTCCT GCGGAACCCG GCCGACTCCC GGCCCCCGGC CTGGCGCGCC 23640 CGGGGCACCG TCCTCATCGC CGGCGACCTC ACGACGGTGC CCGGCCGACT GGTCCGGTCC 23700 CTCCTCGAGG ACGGCGCGGA CCGCGTGGTG CTGGCCGGAC CCGACGCCCC CGCACAGGCC 23760 GCCGCCGCCG GACTGACCGG CGTCTCCCTC GTCCCCGTGC GCTGCGACGT CACCGACCGC 23820 GCCGCACTGG CCGCGCTGCT CGACGAGCAC GCGCCCACCG TCGCCGTGCA CGCCCCGCCC 23880 CTGGTGCCCC TGGCGCCGCT GCGGGAGACG GCACCCGGCG ACATCGCCGC CGCCCTCGCC 23940 GCCAAGACCA CGGCCGCCGG CCACCTGGTC GACCTGGCGC CGGCCGCGGG CCTCGACGCG 24000 CTGGTGCTGT TCTCCTCGGT CTCCGGAGTG TGGGGCGGCG CGGCCCAGGG CGGCTACGCG 24060 GCCGCCAGCG CGCACCTCGA CGCGCTGGCC GAACGCGCCC GCGCCGCGGG GGTGCCCGCG 24120 TTCTCCGTGG CCTGGAGCCC CTGGGCCGGA GGCACGCCCG CCGACGGTGC CGAGGCGGAG 24180 TTCCTCAGCC GGCGCGGGCT GGCTCCCCTC GACCCCGACC AGGCGGTGCG GACCCTGCGC 24240 CGCATGCTGG AGCGCGGCAG CGCCTGCGGT GCGGTCGCCG ACGTCGAGTG GAGCCGGTTC 24300 GCCGCCTCCT ACACCTGGGT GCGTCCCGCC GTACTCTTCG ACGACATCCC GGACGTGCAG 24360 CGGCTGCGCG CGGCCGAACT CGCCCCGAGC ACCGGAGACT CGACCACCTC CGAACTCGTC 24420 CGCGAGCTGA CCGCGCAGTC CGGCCACAAG CGGCACGCCA CCCTGCTGCG GCTGGTGCGC 24480 GCACACGCCG CCGCCGTCCT CGGACAGTCC TCCGGCGACG CGGTGAGCAG CGCCCGCGCC 24540 TTCCGCGACC TCGGCTTCGA CTCGCTGACC GCCCTCGAAC TGCGCGACCG GCTCAGCACC 24600 AGCACCGGGC TCAAACTGCC CACCTCCCTG GTCTTCGACC ACTCCAGCCC GGCCGCGCTC 24660 GCCCGGCACC TCGGTGAGGA ACTCCTCGGC CGGAACGACA CCGCCGACCG GGCCGGCCCC 24720 GACACCCCGG TACGGACGGA CGAGCCCATC GCCATCATCG GCATGGCCTG CCGGCTGCCC 24780 GGCGGGGTGC AGTCCCCCGA GGACCTGTGG GACCTGCTGA CCGGTGGGAC CGACGCCATC 24840 ACCCCCTTCC CGACCAACCG GGGATGGGAC AACGAGACCC TCTACGACCC CGACCCCGAC 24900 TCGCCCGGGC ACCACACCTA CGTGCGCGAG GGCGGGTTCC TGCACGACGC GGCCGAGTTC 24960 GACCCCGGCT TCTTCGGCAT CAGCCCCCGC GAGGCCCTGG CCATGGACCC GCAGCAGCGG 25020 CTGATCCTGG AGACGTCCTG GGAGTCCTTC GAACGGGCCG GCATCGACCC GGTCGAACTG 25080 CGCGGCAGCC GCACCGGGGT CTTCGTCGGC ACCAACGGAC AGCACTACGT GCCGCTCCTC 25140 CAGGACGGCG ACGAGAACTT CGACGGCTAC ATCGCCACCG GCAACTCCGC CAGCGTGATG 25200 TCCGGCCGGC TCTCCTACGT CTTCGGACTG GAGGGCCCCG CCGTCACCGT CGACACCGCC 25260 TGCTCGGCCT CCCTGGCCGC ACTGCACCTG GCGGTGCAGT CACTGCGCCG CGGCGAATGC 25320 GACTACGCCC TCGCCGGCGG GGCCACGGTG ATGTCCACCC CCGAGATGCT GGTGGAGTTC 25380 GCCCGTCAGC GAGCGGTGTC GCCGGACGGC CGCAGCAAGG CGTTCGCGGA GGCGGCCGAC 25440 GGGGTCGGTC TCGCCGAGGG AGCCGGGATG CTGCTCGTGG AGCGGCTGTC GGAGGCGCAG 25500 AAGAAGGGCC ATCCGGTACT GGCGGTGGTG CGGGGCAGTG CCGTCAACCA GGACGGTGCC 25560 AGCAACGGCC TCACCGCACC CAGCGGGCCC GCCCAGCAGC GGGTGATACG GGAGGCGCTG 25620 GCCGACGCGG GGCTGACGCC CGCCGACGTG GACGCGGTCG AGGCGCACGG CACCGGCACG 25680 CCGCTCGGCG ACCCCATCGA GGCCGGCGCG CTGCTCGCCA CGTACGGCCG GGACCGGCGC 25740 GACGGCCCGC TGTGGCTGGG TTCGCTGAAG TCGAACATCG GGCACACCCA GGCCGCCGCC 25800 GGCGTGGCCG GGGTGATCAA GATGGTGCTG GCGCTGCGCC ACGGCGAGCT GCCGCGCACC 25860 CTGCACGCGT CGACGGCGTC GTCCAGGATC GATTGGGACG CGGGCGCCGT GGAGTTGCTG 25920 GACGAGGCCA GGCCCTGGCT CCAGCGGGCC GAGGGGCCGC GCCGGGCGGG CATCTCCTCG 25980 TTCGGCATCA GCGGCACCAA CGCGCACCTC GTCATCGAGG AGCCGCCGGA GCCCACCGCG 26040 CCCGAACTGC TCGCGCCCGA ACCGGCCGCC GACGGCGACG TCTGGTCCGA GGAGTGGTGG 26100 CACGAGGTGA CCGTGCCCCT GATGATGTCC GCGCACAACG AAGCCGCCCT GCGCGACCAG 26160 GCGCGGCGCC TGCGCGCCGA CCTGCTCGCC CACCCCGAGC TGCACCCGGC CGACGTCGGC 26220 TACACCCTCA TCACCACCCG CACCCGGTTC GAGCAGCGGG CCGCCGTCGT CGGCGAGAAC 26280 TTCACGGAGC TGATCGCGGC CCTCGACGAC CTCGTCGAAG GCCGACCGCA CCCGCTCGTG 26340 CTGCGGGGCA CCGCCGGCAC CTCCGACCAG GTCGTGTTCG TCTTCCCCGG CCAGGGCTCG 26400 CAGTGGCCCG AGATGGCCGA CGGGCTGCTG GCCCGCTCCA GCGGCTCCGG CTCCTTCCTG 26460 GAGACCGCCC GCGCCTGCGA CCTCGCGCTC CGGCCCCACC TCGGCTGGTC CGTCCTGGAC 26520 GTACTGCGCC GGGAACCCGG CGCGCCCTCG CTCGACCGGG TCGACGTGGT GCAGCCCGTG 26580 CTGTTCACCA TGATGGTCTC GCTCGCCGAG ACGTGGCGTT CGCTGGGCGT CGAACCGGCC 26640 GCGGTCGTCG GTCACTCCCA GGGCGAGATC GCCGCCGCCT ACGTCGCCGG CGCCCTGACG 26700 CTGGACGACG CGGCGCGCAT CGTCGCCCTG CGCAGCCAGG CGTGGCTGCG GCTGGCCGGC 26760 AAGGGCGGCA TGGTCGCCGT GACCCTGTCC GAACGCGACC TGCGTCCCCG CCTGGAGCCC 26820 TGGAGCGACC GGCTCGCCGT CGCCGCCGTC AACGGCCCCG AGACCTGCGC CGTCTCCGGG 26880 GACCCGGACG CCCTGGCGGA GCTGGTCGCC GAACTCGGTG CGGAGGGCGT GCACGCCCGC 26940 CCCATCCCCG GCGTCGACAC CGCCGGGCAC TCGCCGCAGG TCGACACGCT GGAGGCCCAC 27000 CTGCGGAAGG TGCTCGCGCC CGTCGCGCCC CGCACCTCCG ACATCCCGTT CTACTCGACG 27060 GTCACCGGAG GACTGATCGA CACCGCCGAG CTGGACGCCG ACTACTGGTA CCGCAACATG 27120 CGCGAGCCGG TGGAGTTCGA GCAGGCCACC CGCGCCCTGA TCGCCGACGG CCACGACGTG 27180 TTCCTGGAGT CGAGCCCGCA CCCCATGCTG GCCGTCTCCC TCCAGGAGAC GATCAGCGAC 27240 GCCGGTTCCC CGGCGGCCGT CCTCGGCACC CTGCGGCGCG GCCAGGGCGG CCCCCGCTGG 27300 CTGGGCGTCG CCCTCTGCCG CGCCTACACC CACGGCCTGG AGATCGACGC CGAGGCCATC 27360 TTCGGCCCCG ACTCACGCCA GGTGGAACTG CCCACGTACC CCTTCCAGCG CGAGCGCTAC 27420 TGGTACAGCC CCGGCCACCG CGGTGACGAC CCCGCCTCCC TCGGTCTGGA CGCCGTCGAC 27480 CACCCGCTGC TGGGCAGCGG CGTCGAACTG CCGGAGTCCG GTGACCGGAT GTACACCGCA 27540 CGGCTGGGCG CCGACACCAC CCCGTGGCTG GCCGACCACG CGCTGCTGGG GTCGCCGCTG 27600 CTGCCCGGCG CCGCCTTCGC CGACCTGGCG CTCTGGGCCG GCCGCCAGGC CGGCACCGGC 27660 CGCGTCGAGG AGCTCACCCT GGCCGCGCCC CTGGTGCTGC CCGGCTCCGG GGGTGTCCGG 27720 CTGCGGCTGA ACGTCGGCGC CCCGGGCACC GACGACGCCC GCCGCTTCGC CGTGCACGCC 27780 CGCGCCGAGG GCGCCACGGA CTGGACCCTG CACGCCGAGG GGCTGCTCAC CGCGCAGGAC 27840 ACGGCCGACG CGCCGGACGC CTCGGCGGCC ACCCCGCCCC CCGGCGCCGA ACAACTGGAC 27900 ATCGGCGACT TCTACCAGCG CTTCTCCGAA CTCGGTTACG GCTACGGCCC GTTCTTCCGG 27960 GGACTGGTGA GCGCCCACCG CTGCGGCCCC GACATCCACG CGGAGGTCGC GCTGCCCGTC 28020 CAGGCGCAGG GCGACGCGGC CCGCTTCGGC ATCCATCCCG CGCTGCTGGA CGCGGCGCTG 28080 CAGACCATGA GCCTCGGGGG CTTCTTCCCC GAGGACGGCC GCGTCCGCAT GCCGTTCGCC 28140 CTGCGCGGCG TTCGGCTGTA CCGCGCCGGA GCCGACCGGC TGCACGTGCG CGTCTCGCCC 28200 GTCTCCGAGG ACGCGGTCCG CATCAGGTGC GCCGACGGCG AGGGACGGCC GGTCGCCGAG 28260 ATCGAGTCCT TCATCATGCG GCCGGTCGAC CCGGGACAGC TCCTGGGCGG CCGCCCGGTC 28320 GGCGCCGACG CGCTCTTCCG CATCGCCTGG CGGGAACTCG CCGCCGGCCC GGGCACCCGT 28380 ACCGGCGACG GCACCCCTCC CCCGGTGCGC TGGGTGCTGG CGGGACCCGA CGCGCTGGGC 28440 CTGGCCGAGG CGGCCGACGC CCACCTGCCC GCCGTTCCCG GCCCGGACGG CGCACTGCCG 28500 TCCCCGACGG GACGCCCGGC GCCGGACGCC GTCGTGTTCG CGGTCCGTGC CGGGACCGGC 28560 GACGTCGCCG CCGACGCGCA CACCGTGGCC TGCCGGGTGC TGGACCTCGT CCAGCGCCGG 28620 CTCGCGGCCC CGGAGGGCCC GGACGGCGCC CGCCTGGTGG TGGCCACCCG CGGCGCGGTC 28680 GCCGTACGCG ACGACGCCGA GGTGGACGAC CCGGCCGCGG CCGCCGCGTG GGGCCTGCTG 28740 CGCTCCGCGC AGGCCGAGGA GCCCGGCCGG TTCCTGCTCG TGGACCTGGA CGACGACCCG 28800 GCGTCCGCCC GGGCGCTGAC CGACGCCCTC GCCTCCGGCG AACCGCAGAC CGCGGTCCGG 28860 GCCGGGACGG TGTACGTGCC CCGGCTGGAG CGGGCCGCCG ACCGCACGGA CGGGCCGCTC 28920 ACCCCGCCCG ACGACGGTGC CTGGCGGCTG GGCCGGGGCA CCGACCTCAC CCTCGACGGC 28980 CTCGCCCTGG TGCCCGCCCC GGACGCCGAG GCGCCGCTGG AGCCCGGCCA GGTGCGCGTC 29040 GCCGTACGCG CCGCGGGCGT CAACTTCCGC GACGCCCTCA TCGCCCTCGG CATGTACCCG 29100 GGCGAGGCGG AGATGGGAAC GGAGGGCGCC GGCACCGTCG TCGAGGTCGG CCCCGGCGTC 29160 ACCGGTGTCG CCGTCGGCGA CCGCGTGCTC GGCCTGTGGG ACGGCGGCCT GGGCCCGCTG 29220 TGCGTGGCCG ACCACCGGCT GCTCGCCCCC GTCCCGGACG GCTGGTCCTA CGCCCAGGCC 29280 GCCTCGGTCC CCGCGGTGTT CCTCAGCGCC TACTACGGTC TGGTCACCCT GGCCGGCCTC 29340 AGGCCGGGGG AGCGGGTGCT CGTGCACGCC GCCGCCGGGG GCGTCGGCAT GGCCGCGGTG 29400 CAGATCGCCC GCCACCTCGG CGCGGAGGTG CTGGCCACCG CGAGCCCCGG CAAGTGGGAC 29460 GCCCTGCGCG CCATGGGCAT CACCGACGAC CACCTCGCCT CCTCCCGCAC CCTCGACTTC 29520 GCGACCGCCT TCACCGGAGC GGACGGCACG TCCCGCGCGG ACGTCGTCCT GAACTCGCTC 29580 ACCAAGGAGT TCGTGGACGC CTCCCTCGGG CTGCTCCGTC CGGGCGGCCG GTTCCTGGAG 29640 CTGGGCAAGA CCGACGTCCG GGACCCCGAG CGGATCGCCG CCGAACACCC CGGGGTGCGC 29700 TACCGGGCGT TCGACCTCAA CGAGGCCGGA CCCGACGCAC TCGGCCGGCT GCTGCGGGAA 29760 CTGATGGACC TGTTCGCCGC CGGCGTGCTG CACCCGCTGC CCGTCGTCAC CCACGACGTG 29820 CGCCGGGCCG CGGACGCCCT GCGCACCATC AGCCAGGCCC GGCACACCGG AAAGCTCGTC 29880 CTGACCATGC CGCCCGCCTG GCACCCGTAC GGCACGGTCC TGGTCACCGG TGGCACCGGC 29940 GCCCTCGGCA GCCGCATCGC CCGCCACCTG GCGAGCCGGC ACGGCGTCCG CCGGCTGCTG 30000 ATCGCCGCCC GCCGGGGCCC GGACGGCGAG GGCGCCGCGG AGCTGGTCGC CGACCTCGCC 30060 GCCCTGGGCG CGTCGGCCAC CGTGGTCGCC TGCGACGTCT CCGACGCGGA CGCCGTCCGC 30120 GGACTGCTCG CCGGCATACC GGCCGATCAC CCGCTGACGG CGGTGGTGCA CAGCACCGGC 30180 GTCCTCGACG ACGGCGTGCT GCCCGGGCTC ACCCCCGAGC GGATGCGGCG CGTGCTGCGG 30240 CCCAAGGTGG AGGCCGCCGT CCACCTGGAC GAACTCACCC GCGACCTCGA CCTGTCGGCG 30300 TTCGTCCTCT TCTCCTCCAG CGCCGGTCTG CTGGGCAGCC CGGCCCAGGG CAACTACGCG 30360 GCGGCCAACG CCACCCTCGA CGCCCTCGCC GCCCGGCGCC GGTCCCTCGG CCTCCCGTCG 30420 GTGTCACTCG CCTGGGGTCT GTGGTCCGAC ACCAGCCGGA TGGCACACGC ACTGGACCAG 30480 GAGAGCCTCC AGCGGCGCTT CGCCCGCAGC GGCTTCCCGC CCCTGTCCGC CACGCTGGGC 30540 GCCGCGCTGT TCGACGCCGC CCTGCGGGTC GACGAGGCCG TGCAGGTCCC CATGCGGTTC 30600 GACCCGGCCG CGCTGCGCGC CACCGGAAGC GTCCCCGCCC TGCTGTCGGA CCTCGTCGGG 30660 TCCGCCCCGG CGACCGGGTC CGCGGCCCCG GCGTCCGGCC CCCTTCCGGC TCCGGACGCC 30720 GGGACCGTCG GCGAGCCGCT CGCCGAGCGG TTGGCCGGAC TCTCCGCCGA GGAACGCCAC 30780 GACCGGCTGC TCGGCCTGGT CGGCGAACAC GTGGCCGCGG TACTGGGCCA CGGCTCCGCC 30840 GCCGAGGTCC GGCCCGACCG GCCGTTCCGC GAGGTCGGGT TCGACTCGCT CACGGCCGTG 30900 GAACTGCGCA ACCGGATGGC GGCGGTCACC GGGGTCAGGC TCCCCGCCAC CCTGGTCTTC 30960 GACCACCCCA CCCCCGCCGC GCTGTCCTCG CACCTCGACG GCCTGCTGGC CCCGGCACAG 31020 CCGGTCACCA CCACACCGCT GCTGTCCGAA CTGGACCGCA TCGAGGAGGC CCTGGCCGCC 31080 CTCACCCCCG AGCACCTCGC GGAGCTCGCC CCCGCCCCCG ACGACCGGGC CGAGGTCGCC 31140 CTGCGCCTGG ACGCCCTGGC CGACCGCTGG CGCGCCCTGC ACGACGGCGC GCCCGGCGCC 31200 GACGACGACA TCACCGACGT GCTGAGCAGC GCCGACGACG ACGAGATCTT CGCGTTCATC 31260 GACGAGCGGT ACGGCACGTC GTGACCGCCG GCCCGGAGCC CCGCCCGTCA TCGAAAGGAA 31320 GCACCACCAT GGCGAACGAA GAGAAGCTGC GCGCCTACCT CAAGCGCGTG ACGGGTGAGC 31380 TGCACCGGGC CACCGAGCAG CTGCGTGCCC TGGACCGGCG GGCCCACGAG CCGATCGCGA 31440 TCGTCGGGGC GGCCTGCCGA CTCCCCGGCG GCGTCGAGAG TCCGGACGAC CTGTGGGAGC 31500 TGCTGCACGC CGGTGCCGAC GCGGTCGGCC CGGCCCCCGC CGACCGCGGC TGGGACGTGG 31560 AGGGAAGGTA CTCGCCCGAC CCCGACACGC CCGGCACCTC GTACTGCCGC GAGGGCGGCT 31620 TCGTGCAGGG GGCCGACCGG TTCGACCCCG CCCTCTTCGG CATCTCGCCC AACGAGGCGC 31680 TCACCATGGA CCCCCAGCAG CGGCTGCTGC TGGAGACCTC CTGGGAGGCG CTGGAGCGAG 31740 CCGGTCTGGA CCCCCAGTCC CTGGCGGGCA GCCGGACCGG CGTGTTCGCC GGGGCGTGGG 31800 AGAGCGGCTA CCAGAAGGGC GTCGAAGGGC TCGAAGCCGA TCTGGAGGCC CAACTCCTGG 31860 CCGGCATCGT CAGCTTCACC GCCGGCCGCG TCGCCTACGC CCTGGGCCTG GAGGGCCCGG 31920 CGCTGACGAT CGACACGGCC TGCTCCTCGT CGCTGGTGGC ACTGCACCTG GCGGTGCAGT 31980 CACTGCGCCG GGGCGAGTGC GACCTCGCAC TGGCGGGCGG CGCCACGGTC ATCGCCGACT 32040 TCGCGCTCTT CACCCAGTTC TCCCGGCAGC GCGGGCTCGC CCCCGACGGG CGGTGCAAGG 32100 CCTTCGGTGA GACGGCCGAC GGCTTCGGCC CCGCCGAGGG CGCGGGGATG CTGCTGGTCG 32160 AGCGGCTGTC GGACGCCCGC CGCAACGGGC ACCCGGTGCT GGCGGTGGTG CGGGGCAGTG 32220 CCGTCAACCA GGACGGTGCG AGCAATGGGC TGACGGCGCC GAGTGGTCCT GCGCAGCAGC 32280 GGGTGATCCG TGAGGCGCTG GCCGACGCGG GGCTGACGCC CGCCGACGTG GACGCGGTCG 32340 AGGCGCACGG CACCGGCACG CCGCTCGGCG ACCCCATCGA GGCCGGCGCG CTCATGGCGA 32400 CGTACGGGCA CGAACGGACG GGCGACCCGC TGTGGCTGGG TTCGCTGAAG TCGAACATCG 32460 GGCACACCCA GGCCGCCGCC GGCGTGGCCG GGGTGATCAA GATGGTGCTG GCGCTGCGCC 32520 ACGGTGAGCT GCCGCGCACC CTGCACGCGT CGACGGCGTC CTCCAGGATC GAATGGGACG 32580 CGGGCGCCGT GGAGTTGCTG GACGAGGCCA GGCCCTGGCC CCGGCGTGCC GAGGGGCCGC 32640 GCCGGGCGGG CATCTCCTCG TTCGGCATCA GCGGCACCAA CGCGCACCTC GTCATCGAGG 32700 AGGAGCCGCC CGCCCGGCCG GAGCCCGAGG AGGCCGCGCA GCCGCCCGCC CCGGCCACCA 32760 CCGTCCTCCC GCTGTCGGCC GCCGGCGCGC GATCCCTGCG CGAGCAGGCC CGCAGGCTCG 32820 CCGCGCACCT GGCCGGCCAC GAGGAGATCA CCGCCGCCGA CGCCGCCCGC TCCGCCGCCA 32880 CCACCCGTGC CGCGCTCTCG CACCGGGCCT CGGTCCTGGC CGACGACCGG CGGGCGCTGA 32940 TCGACAGGCT GACCGCGCTG GCGGAGGACA GGAAGGACCC CGGCGTCACC GTCGGCGAGG 33000 CGGGCAGCGG CCGGCCCCCC GTCTTCGTCT TCCCGGGACA GGGCTCCCAG TGGACGGGCA 33060 TGGGCGCCGA ACTCCTGGAC AGGGCACCGG TCTTCCGCGC CAAGGCCGAG GAGTGCGCGC 33120 GGGCCCTCGC GGCCCACCTC GACTGGTCGG TGCTCGACGT CCTGCGCGAC GCGCCCGGCG 33180 CCCCGCCGAT CGACCGCGCG GACGTCGTCC AGCCGACCCT GTTCACCATG ATGGTCTCCC 33240 TCGCGGCGCT GTGGGAGTCC CACGGTGTAC GGCCCGCCGC CGTGGTCGGC CACTCCCAAG 33300 GCGAGATCGC CGCCGCCCAC GCGGCCGGTG CCCTGTCCCT CGACGACGCG GCCCGCGTGA 33360 TCGCCGAGCG CAGCAGGCTC TGGAAGCGGC TGGCCGGAAA CGGCGGCATG CTCTCCGTGA 33420 TGGCCCCGGC CGACCGGGTC CGCGAACTGA TGGAGCCCTG GGCGGAGCGG ATGTCCGTGG 33480 CCGCCGTCAA CGGCCCCGCC TCGGTCACCG TGGCCGGTGA CGCGCGGGCG CTGGAGGAGT 33540 TCGGCGGCCG GCTCTCCGCC GCCGGGGTGC TGCGCTGGCC CCTCGCCGGC GTCGACTTCG 33600 CCGGACACTC ACCCCAGGTG GAGCAGTTCC GCGCCGAGCT CCTCGACACG CTGGGCACCG 33660 TCCGCCCGAC CGCCGCCCGG CTGCCCTTCT TCTCCACCGT GACCGCCGCG GCGCACGAGC 33720 CCGAAGGCCT GGACGCCGCG TACTGGTACC GGAACATGCG CGAACCCGTG GAGTTCGCGT 33780 CCACCCTGCG GACGCTGCTG CGCGAGGGCC ACCGCACCTT CGTCGAGATG GGCCCGCACC 33840 CCCTGCTGGG CGCCGCGATC GACGAGGTCG CCGAGGCCGA GGGCGTGCAC GCCACCGCCC 33900 TCGCCACCCT CCACCGCGGC TCCGGCGGCC TGGACCGGTT CCGCTCCTCG GTGGGCGCCG 33960 CGTTCGCCCA CGGAGTACGG GTCGACTGGG ACGCCCTCTT CGAGGGCTCC GGCGCCCGCC 34020 GGGTCCCGCT GCCCACCTAC GCCTTCAGCC GGGACCGGTA CTGGCTGCCC ACCGCCATCG 34080 GCCGGCGCGC CGTCGAGGCG GCCCCCGTCG ACGCGTCCGC CCCCGGGCGC TACCGCGTCA 34140 CCTGGACACC CGTGGCATCC GACGACTCCG GCCGGCCCTC CGGGCGCTGG CTGCTGGTGC 34200 AGACCCCCGG CACCGCGCCG GACGAGGCGG ACACCGCGGC GTCGGCCCTC GGTGCGGCCG 34260 GGGTGGTCGT GGAGCGCTGC CTGCTGGATC CCACCGAGGC CGCGCGCGTC ACGCTCACCG 34320 AGCGACTGGC CGAACTGGAC GCGCAGCCGG AGGGCCTGGC CGGCGTGCTG GTGCTGCCCG 34380 GCCGTCCGCA GAGCACCGCA CCGGCCGACG CCTCCCCGCT CGACCCGGGG ACGGCCGCCG 34440 TCCTGCTCGT GGTCCAGGCC GTGCCGGACG CCGCTCCGAA GGCCCGGATC TGGGTGGTGA 34500 CGCGGGGTGC GGTGGCGGTG GGGTCGGGTG AGGTGCCGTG TGCGGTGGGT GCGCGGGTGT 34560 GGGGTCTGGG GCGGGTGGCT GCGTTGGAGG TGCCGGTGCA GTGGGGTGGG TTGGTGGATG 34620 TGGCGGTGGG GGCGGGTGTG CGTGAGTGGC GTCGTGTGGT GGGTGTGGTT GCGGGGGGTG 34680 GTGAGGATCA GGTGGCGGTG CGTGGTGGGG GTGTGTTCGG TCGTCGTCTG GTGGGTGTGG 34740 GGGTGCGGGG TGGTTCGGGG GTGTGGCGTG CGCGGGGGTG TGTGGTGGTG ACGGGTGGGT 34800 TGGGTGGTGT GGGGGGTCAT GTGGCGCGGT GGTTGGCGCG TTCGGGTGCG GAGCATGTGG 34860 TGTTGGCGGG GCGTCGGGGT GGTGGGGTTG TGGGGGCGGT GGAGTTGGAG CGGGAGTTGG 34920 TGGGGTTGGG GGCGAAGGTG ACGTTCGTTT CGTGTGATGT GGGGGATCGG GCGTCGATGG 34980 TGGGGTTGTT GGGTGTGGTG GAGGGGTTGG GGGTGCCGTT GCGTGGTGTG TTTCATGCGG 35040 CGGGGGTGGC TCAGGTGTCG GGGTTGGGTG AGGTGTCGTT GGCGGAGGCG GGTGGTGTGT 35100 TGGGGGGTAA GGCGGTGGGG GCTGAGTTGT TGGACGAGTT GACGGCGGGT GTGGAGCTGG 35160 ATGCGTTCGT GTTGTTCTCG TCGGGTGCTG GGGTGTGGGG GAGTGGGGGG CAGTCGGTGT 35220 ATGCGGCGGC CAATGCGCAT CTGGATGCGT TGGCGGAGCG TCGTCGTGCG CAGGGGCGTC 35280 CCGCGACCTC CGTCGCCTGG GGCCTGTGGG GCGGCGAGGG CATGGGAGCG GACGAAGGCG 35340 TCACGGAGTT CTACGCCGAG CGCGGCCTCG CCCCCATGCG GCCCGAGTCG GGCATCGAGG 35400 CACTGCACAC GGCACTGAAC GAGGGCGACA CCTGCGTCAC GGTCGCCGAC ATCGACTGGG 35460 AACACTTCGT CACCGGGTTC ACCGCCTACC GGCCCAGCCC GCTGATCTCC GACATCCCCC 35520 AGGTCCGCGC GTTGCGCACG CCCGAACCCA CCGTGGACGC CTCGGACGGA CTGCGCCGGC 35580 GCGTCGACGC CGCCCTCACC CCGCGCGAGC GCACCAAGGT CCTGGTCGAC CTGGTCCGCA 35640 CGGTGGCGGC GGAGGTCCTC GGTCACGACG GGATCGGCGG CATCGGCCAC GACGTGGCCT 35700 TCCGGGACCT CGGCTTCGAC TCGCTGGCCG CGGTGCGGAT GCGCGGCCGG CTGGCCGAGG 35760 CGACCGGACT CGTACTGCCC GCGACGGTCA TCTTCGACCA CCCCACCGTG GACCGGCTCG 35820 GCGGCGCGCT GCTGGAGCGG CTGTCCGCGG ACGAACCCGC GCCCGGCGGG GCGCCGGAGC 35880 CCGCCGGGGG GAGGCCCGCG ACCCCACCGC CCGCACCGGA GCCGGCCGTC CACGACGCCG 35940 ACATCGACGA ACTCGACGCG GACGCCCTGA TCCGGCTGGC CACGGGAACC GCCGGACCGG 36000 CCGACGGCAC GCCGGCCGAC GGCGGGCCCG ACGCGGCGGC GACCGCCCCC GACGGAGCAC 36060 CGGAGCAGTA GCGCGCCCTC ACCGGCGCGC CGACCGGCGG AGCGCCGTAC CGCCGACGCC 36120 CCCCACAGCC AGCGAGCAGA CGAGGAAGCC GAAGATGTCA CCGTCCATGG ACGAAGTGCT 36180 GGGTGCGCTG CGCACCTCCG TCAAGGAGAC CGAGCGGCTG CGCCGGCACA ACCGGGAGCT 36240 CCTGGCCGGC GCGCACGAGC CGGTCGCCAT CGTGGGCATG GCCTGCCGCT ACCCCGGTGG 36300 CGTGAGCACC CCGGACGACC TGTGGGAGCT CGCCGCGGAC GGCGTCGACG CGATCACCCC 36360 CTTCCCGGCC GACCGGGGCT GGGACGAGGA CGCCGTCTAC TCGCCCGACC CCGACACCCC 36420 CGGCACCACC TACTGCCGTG AGGGCGGCTT CCTCACCGGC GCCGGGGACT TCGACGCGGC 36480 CTTCTTCGGC ATCTCGCCGA ACGAGGCGCT GGTGATGGAC CCGCAGCAGC GGCTGTTGCT 36540 GGAGACGTCG TGGGAGACGT TGGAGCGGGC CGGCATCGTC CCCGCGTCGC TGCGCGGCAG 36600 CCGTACCGGT GTCTTCGTCG GAGCCGCGCA CACGGGATAC GTCACCGACA CCGCGCGAGC 36660 GCCCGAGGGC ACCGAGGGCT ATCTGCTGAC GGGCAACGCC GATGCCGTCA TGTCCGGCCG 36720 GATCGCCTAC TCCCTGGGTC TGGAGGGGCC GGCGCTGACG ATCGGGACGG CCTGCTCGTC 36780 GTCGTTGGTG GCGTTGCATC TGGCGGTGCA GTCGTTGCGG CGGGGCGAGT GCGACCTGGC 36840 GTTGGCCGGC GGCGTCGCGG TCATGCCCGA CCCGACGGTG TTCGTGGAGT TCTCGCGGCA 36900 GCGGGGGCTG GCGGTGGACG GGCGGTGCAA GGCGTTCGCG GAGGGTGCGG ACGGGACGGC 36960 GTGGGCGGAG GGAGTGGGTG TGCTGCTGGT GGAGCGGCTT TCCGACGCGC GCCGCAATGG 37020 CCATCGGGTG CTGGCGGTGG TGCGGGGCAG TGCGGTCAAT CAGGACGGGG CGAGCAATGG 37080 GCTGACGGCG CCGAGTGGTC CTGCGCAGCA GCGGGTGATC CGTGAGGCGC TGGCTGATGC 37140 GGGGCTGACG CCCGCCGACG TGGATGTGGT GGAGGCGCAC GGTACGGGGA CGGCGTTGGG 37200 TGATCCGATC GAGGCGGGTG CGTTGCTGGC CACGTACGGG CGGGAGCGGG TCGGTGATCC 37260 TTTGTGGTTG GGGTCGTTGA AGTCGAACAT CGGGCATGCG CAGGCGGCTG CGGGTGTGGG 37320 TGGTGTGATC AAGGTGGTGC AGGCGATGCG GCATGGGTCG TTGCCGCGGA CGCTGCATGT 37380 GGATGCGCCG TCGTCGAAGG TGGAGTGGGC TTCGGGTGCG GTGGAGCTGC TGACCGAGGG 37440 CCGGTCGTGG CCGCGGCGGG TGGAGCGGGT GCGGCGGGCC GCGGTGTCGG CGTTCGGGGT 37500 GAGCGGGACC AACGCCCATG TGGTCCTGGA GGAAGCACCG GTCGAGGCCG GGAGCGAGCA 37560 CGGGGACGGC CCCGGACCCG ACCGGCCCGA CGCCGTGACG GGTCCGCTCC CCTGGGTGCT 37620 CTCGGCACGC TCGCGGGAGG CGCTGCGCGG CCAGGCCGGA CGACTCGCCG CTCTCGCCCG 37680 CCAGGGGCGC ACGGAGGGCA CCGGCGGCGG CAGCGGACTC GTCGTCCCCG CGGCCGACAT 37740 CGGATACTCC CTGGCCACCA CCAGGGAGAC CCTGGAGCAC CGGGCGGTGG CGCTGGTGCA 37800 GGAGAACCGG ACGGCCGGGG AGGACCTCGC CGCGCTGGCC GCCGGCCGCA CACCGGAGAG 37860 CGTGGTCACG GGTGTCGCGC GACGTGGCCG CGGGATCGCC TTCCTCTGCT CGGGGCAGGG 37920 CGCCCAGCGG CTCGGCGCCG GTCGGGAGCT CCGCGGCAGG TTCCCCGTCT TCGCCGACGC 37980 CCTCGACGAG ATCGCGGCGG AGTTCGACGC CCACCTCGAA CGCCCTCTCC TGTCGGTGAT 38040 GTTCGCCGAG CCCGCCACGC CGGACGCCGC ACTCCTCGAC CGCACCGACT ACACCCAGCC 38100 GGCCCTCTTC GCGGTGGAGA CCGCGCTCTT CCGGCTCCTG GAGAGCTGGG GCCTGGTCCC 38160 GGACGTCCTC GTGGGCCACT CGATCGGCGG TCTGGTGGCG GCTCACGTGG CGGGCGTCTT 38220 CTCTGCGGCC GACGCGGCCC GGCTGGTCTC CGCACGCGGC CGGCTCATGC GGGCCCTGCC 38280 CGAGGGCGGC GCGATGGCGG CCGTGCAGGC CACCGAGCGG GAGGCCGCCG CGCTGGAGCC 38340 CGTCGCCGCC GGCGGCGCGG TGGTCGCCGC GGTCAACGGC CCGCAGGCCC TCGTGCTCTC 38400 CGGGGACGAG GCGGCCGTAC TGGCGGCGGC CGGTGAACTG GCCGCCCGCG GACGCCGCAC 38460 CAAGCGCCTG AGGGTGAGCC ACGCCTTCCA CTCACCCCGT ATGGACGCCA TGCTCGCCGA 38520 CTTCCGCGCG GTGGCGGACA CGGTCGACTA CCACGCCCCC CGGCTGCCGG TCGTCTCCGA 38580 AGTGACCGGC GACCTCGCCG ACGCCGCCCA GCTGACCGAC CCCGGCTACT GGACCCGCCA 38640 GGTGCGGCAG CCGGTGCGCT TCGCCGACGC CGTGCGCACC GCGAGCGCCC GGGACGCCGC 38700 GACCTTCATC GAGCTCGGGC CCGACGCCGT CCTGTGCGGC ATGGCGGAGG AGTCCCTGGC 38760 CGCGGAGGCC GACGTCGTGT TCGCCCCGGC ACTGCGCCGC GGGCGCCCGG AGGGCGACAC 38820 CGTGCTCCGG GCCGCCGCGA GCGCGTACGT CCGCGGCGCG GGCCTCGACT GGGCCGCGCT 38880 CTACGGCGGC ACGGGAGCCC GCCGCACCGA CCTGCCCACC TACGCCTTCC AGCACAGCCG 38940 CTACTGGCTC GCCCCCGCCT CGGCCGCGGT CGCCCCCGCG ACGGCCGCCC CCTCCGTCCG 39000 ATCCGTGCCG GAAGCCGAGC AGGACGGGGC GCTGTGGGCC GCCGTGCACG CCGGTGACGT 39060 CGCCTCGGCC GCGGCGCGAC TGGGCGCCGA CGACGCCGGT ATCGAACACG AACTGCGCGC 39120 GGTCCTGCCG CACCTGGCCG CCTGGCACGA CCGCGACCGC GCGACCGCGC GGACCGCGGG 39180 CCTGCACTAC CGCGTCACCT GGCAGGCGAT CGAGGCAGAC GCTGTCAGGT TCAGCCCCTC 39240 GGATCGCTGG CTGATGGTCG AGCATGGGCA GCACACGGAA TGCGCGGACG CCGCGGAACG 39300 GGCGCTGCGC GCGGCCGGCG CGGAGGTCAC CCGCCTGGTG TGGCCGCTGG AGCAGCACAC 39360 CGGATCACCG CGGACGGAGA CCCCGGACCG CGGCACCCTG GCGGCCCGGC TGGCCGAGCT 39420 CGCACGGAGC CCGGAGGGCC TGGCCGGCGT GCTGCTGCTC CCCGACTCGG GCGGTGCCGC 39480 GGTCGCCGGG CACCCCGGGC TGGACCAGGG AACGGCGGCG GTGCTGCTGA CGATCCAGGC 39540 ACTGACCGAC GCCGCGGTGC GGGCACCGCT GTGGGTGGTG ACGCGGGGTG CGGTGGCGGT 39600 GGGGTCGGGT GAGGTGCCGT GTGCGGTGGG TGCGCGGGTG TGGGGTCTGG GGCGGGTGGC 39660 TGCGTTGGAG GTGCCGGTGC AGTGGGGTGG GTTGGTGGAT GTGGCGGTGG GGGCGGGTGT 39720 GCGTGAGTGG CGTCGTGTGG TGGGTGTGGT TGCGGGGGGT GGTGAGGATC AGGTGGCGGT 39780 GCGTGGTGGG GGTGTGTTCG GTCGTCGTCT GGTGGGTGTG GGGGTGCGGG GTGGTTCGGG 39840 GGTGTGGCGT GCGCGGGGGT GTGTGGTGGT GACGGGTGGG TTGGGTGGTG TGGGGGGTCA 39900 TGTGGCGCGG TGGTTGGCGC GTTCGGGTGC GGAGCATGTG GTGTTGGCGG GGCGTCGGGG 39960 TGGTGGGGTT GTGGGGGCGG TGGAGTTGGA GCGGGAGTTG GTGGGGTTGG GGGCGAAGGT 40020 GACGTTCGTT TCGTGTGATG TGGGGGATCG GGCGTCGGTG GTGGGGTTGT TGGGTGTGGT 40080 GGAGGGGTTG GGGGTGCCGT TGCGTGGTGT GTTTCATGCG GCGGGGGTGG CTCAGGTGTC 40140 GGGGTTGGGT GAGGTGTCGT TGGCGGAGGC GGGTGGTGTG TTGGGGGGTA AGGCGGTGGG 40200 GGCTGAGTTG TTGGACGAGT TGACGGCGGG TGTGGAGCTG GATGCGTTCG TGTTGTTCTC 40260 GTCGGGTGCT GGGGTGTGGG GGAGTGGGGG GCAGTCGGTG TATGCGGCGG CCAATGCGCA 40320 TCTGGATGCG TTGGCGGAGC GTCGTCGTGC GCAGGGGCGT CCCGCGACCT CCGTCGCCTG 40380 GGGCCCGTGG GACGGCGACG GCATGGGCGA GATGGCGCCC GAGGGCTACT TCGCCCGCCA 40440 CGGCGTGGCC CCGCTCCACC CCGAGACGGC GCTCACCGCC CTGCACCAGG CCATCGACGG 40500 CGGCGAAGCC ACGGTCACCG TGGCGGACAT CGACTGGGAA CGGTTCGCCC CCGGCTTCAC 40560 CGCCTTCCGT CCCAGCCCCC TGATCGCCGG CATCCCCGCG GCCCGTACGG CGCCCGCCGC 40620 CGGCCGGCCC GCCGAGGACA CCCCCACCGC CCCCGGCCTC CTGCGGGCGC GGCCCGAGGA 40680 CCGGCCGCGG CTCGCCCTGG ACCTGGTGCT CCGCCACGTC GCGGCGGTCC TCGGCCACTC 40740 CGAGGACGCC CGGGTCGACG CCCGGGCCCC CTTCCGGGAC CTCGGCTTCG ACTCGCTCGC 40800 CGCGGTGCGG CTGCGCCGCC GGCTGGCCGA GGACACCGGG CTCGACCTGC CCGGCACCCT 40860 CGTCTTCGAC CACGAGGACC CCACCGCGCT GGCCCACCAC CTGGCCGGCC TCGCCGACGC 40920 GGGGACCCCC GGCCCCCAGG AGGGCACGGC TCGGGCCGAG AGCGGGCTGT TCGCCTCCTT 40980 CCGCGCCGCC GTCGAACAGC GCAGGTCGAG CGAGGTCGTG GAGCTGATGG CCGACCTGGC 41040 GGCGTTCCGG CCCGCCTACT CCCGGCAGCA CCCCGGCTCC GGCCGCCCCG CGCCCGTACC 41100 CCTCGCGACC GGACCGGCGA CGCGTCCCAC GCTGTACTGC TGCGCCGGCA CCGCGGTCGG 41160 CTCCGGGCCC GCCGAGTACG TCCCGTTCGC CGAAGGACTG CGCGGCGTCC GGGAGACGGT 41220 CGCCCTTCCC CTGTCCGGCT TCGGCGACCC CGCGGAACCG ATGCCCGCAT CGCTCGACGC 41280 GCTGATCGAG GTCCAGGCCG ACGTCCTCCT GGAGCACACC GCGGGCAAGC CCTTCGCCCT 41340 CGCCGGCCAC TCCGCCGGCG CGAACATCGC CCACGCCCTG GCCGCCCGGC TGGAGGAACG 41400 CGGCTCGGGC CCCGCAGCCG TCGTACTGAT GGACGTCTAC CGTCCCGAGG ACCCCGGTGC 41460 GATGGGCGAG TGGCGCGACG ACCTGCTCAG CTGGGCGCTC GAACGCAGCA CGGTGCCCCT 41520 GGAGGACCAC CGGCTCACCG CCATGGCCGG CTATCAGCGG CTGGTGCTCG GAACCCGGCT 41580 CACCGCCCTC GAAGCCCCCG TCCTGCTGGC CCGGGCGTCC GAACCCCTGT GCGCGTGGCC 41640 GCCCGCGGGC GGGGCGCGGG GCGACTGGCG GTCCCAGGTC CCGTTCGCAC GGACCGTCGC 41700 CGACGTGCCC GGCAACCACT TCACCATGCT CACCGAACAC GCCCGGCACA CCGCGTCCCT 41760 GGTGCACGAA TGGCTGGACA GCCTCCCGCA CCAGCCCGGT CCCGCCCCGC TCACCGGAGG 41820 GAAACACTGA TGTACGCCGA CGACATCGCG GCCGTCTACG ACCTGGTCCA CGAGGGGAAG 41880 GGGAAGGACT ACCGGCAGGA GGCCGAGGAG ATCGCCGCAC TCGTGCGCGT CCACCGGCCG 41940 GGCGCCCGGA CCCTGCTCGA CGTGGCCTGC GGCACCGGCC AGCACCTGCA CCACCTGGAC 42000 GGCCTCTTCG ACCACGTCGA GGGCCTGGAA CTCTCCGCCG ACATGCTGGC CCTCGCGACC 42060 GGCCGGAACC CCGGTGTCAC CTTCCACCAA GGGGACATGC GCTCGTTCTC CCTGGGACGC 42120 CGGTTCGACG CGGTGACCTG CATGTTCAGC TCCATAGGCC ACCTGCGGAC CACCGACGAA 42180 CTCGACAGCA CGCTGCGGGC CTTCACCGAC CACCTCGAAC CGTCCGGCGT CATCGTCGTC 42240 GAACCCTGGT GGTTCCCCGA GTCCTTCACC CCCGGTTACG TCGGCGCCAG CATCACGGAG 42300 GCGGGCGAGC GCACCGTCTG CCGGGTCTCG CACTCCGTAC GGGAGGGGAA CGCCACCCGC 42360 ATCGAGGTGC ACTACCTCCT CGCCGGACCC GGCGGCGTCC GTCACCTGAC CGAGGACCAC 42420 ACCATCACCC TGTTCCCGCG CGCCGACTAC GAGGCGGCCT TCGAGCGCGC CGGCTGCGAC 42480 GTGGTCTACC AGGAAGGCGG CCCGTCCGGT CGCGGGCTGT TCATCGGCAC CCGCCGCTGA 42540 CCCGGTGCCG ACGCGGACCG CCGCGGCCCG GAGGCGGGTT GCCCCGACCC ACCCGGCACA 42600 CCCGGGTCCC CCGATCGTGC GAGCGCCCCC ATCGACCCGA GAAGAAAGGC AGGGCAGCCA 42660 TGCCCACCCT TGCCACGGAA ACGGCCCCCG CGAGCACGAG CACGAGCGCG GGCACGAGCA 42720 CGGGCGTCCG TGCGCTCGGC CGTCGGCTCC AGCTGACCCG GGCCGCACAC TGGTGCGCCG 42780 GCAACCAGGG CGACCCGTAC GCGCTGATCC TGCGCGCCGT CGCCGACCCC GAGCCGTTCG 42840 AACGGGAGAT CCGGGCCCGC GGACCGTGGT TCCGCAGCGA ACAGCTGGAC GCCTGGGTGA 42900 CCGCGGACCC CGAGGTGGCG GCGGCCGTCC TGGCCGACCC GCGCTTCGGC ACGCTGGACC 42960 GGGCCGGACG CCGCCCGGAC GAGGAACTGC TGCCCCTCGC CGAGGCGTTC CCCCACCACG 43020 AACGCGCGGA GCTCGTACGC CTGCGGGCGC TGGCCGCCCC GGTGCTCAGC CGGTACGCCC 43080 CGGCCCAGGC GCCCTGCGCG GCGCGCACCA CCGCCCGCAG AGTGCTCGGC CGCCTGCTGC 43140 CCACCGGTGA CGCCGGGTTC GACCTTGTCG GCGAGGTCGC CCGGCCCTAC GCCGTCGAGC 43200 TGATGCTCAG GCTCCTCGGA GTGCCGGGCC GCGACCGCGC CACCGCCGCG CGGGCACTCG 43260 CCGCCTGCGG CCCCCAGCTC GACGCCCGGA TGGCCCCGCA ACTGCTGACC GTGGCCCGGG 43320 AGTCCGCCGA CGCCGTCCGC ACACTGGCCG ACCTGGTCCC CGAGCTCGTC GCGGAGAAGT 43380 CCCGGGGCCT CGGGAACGCC GAGCCCCGGC CCGACGACGT GCTCGCCCTC CTCCTGCACG 43440 ACGGCGTCGC CCCCGGCGAC GTCGAGCGCA TCGCGCTGCT CCTCGCGGTC GGCGCACCCG 43500 AACCCGTCGT CACCGCCGTC GCGCACACGG TCCACCGGCT GCTCGGCCGG CCGGGGGAGT 43560 GGGAGAGGGC CCGCCGGACG CCGGCCGCGG CGAACGCCGT CGACCAGGTG CTGCGCGAGC 43620 GCCCCCCGGC CCGGCTGGAG AACCGGGTCG CGCACACCGG CCTCGAACTC GGCGGCCGCC 43680 GGATCACCGC CGACGAGCAC GTCGTGGTGC TGGCCGCCGC CGGACGGGAG ATCCCCGGGC 43740 CGGAGCCGCT CGGGGGCGCC GACGGACCGC ACCTGGCGCT CGCCCTCCCG CTGATCCGCC 43800 TGGCCGCCAC CACCGCGGTC CAGGTCACGG CCGGCCGCCT GCCCGGCCTG CGGGCCGAGG 43860 GACCGCCCCT GACCCGGCCG CGGTCACCGG TCCTGGGCGC CTGCGCCCGC CTCCGGGTCC 43920 ACCCGGGATG ACCCCGCCGT CCGTACGCCC CCTCCCAGAC CGGAGCCGCT GTGCGCGTCC 43980 TGCTGACATC CCTCGCCCAC AACACCCACT ACTACAGTCT GGTGCCCCTC GCCTGGGCGC 44040 TGCGCGCCGC CGGGCACGAG GTACGGGTGG CGAGCCCGCC CTCCCTCACC GACGTCATCA 44100 CCTCCACCGG TCTGACCGCC GTACCGGTGG GCGACGACCG ACCGGCCGCG GAGCTGCTCG 44160 CCGAGATGGG CAGAGACCTC GTCCCCTACC AGAGGGGCTT CGAGTTCGGT GAGGTGGAGA 44220 3GCGAGGAGGA GACCACCTGG GAGTACCTGC TCGGCCAGCA GAGCATGATG GCCGCCCTG 44280 GCTTCGCCCC GTTCAACGGC GCCGCCACGA TGGACGAGAT CGTCGACTTC GCCCGTGGCT 44340 GGCGGCCCGA CCTGGTCGTG TGGGAACCCT GGACCTA 44377

【００４２】配列番号：８配列の長さ：４５５０アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類: 蛋白質配列 Met Ser Gly Glu Leu Ala Ile Ser Arg Ser Asp Asp Arg Ser Asp Ala 1 5 10 15 Val Ala Val Val Gly Met Ala Cys Arg Phe Pro Gly Ala Pro Gly Ile 20 25 30 Ala Glu Phe Trp Lys Leu Leu Thr Asp Gly Arg Asp Ala Ile Gly Arg 35 40 45 Asp Ala Asp Gly Arg Arg Arg Gly Met Ile Glu Ala Pro Gly Asp Phe 50 55 60 Asp Ala Ala Phe Phe Gly Met Ser Pro Arg Glu Ala Ala Glu Thr Asp 65 70 75 80 Pro Gln Gln Arg Leu Met Leu Glu Leu Gly Trp Glu Ala Leu Glu Asp 85 90 95 Ala Gly Ile Val Pro Gly Ser Leu Arg Gly Glu Ala Val Gly Val Phe 100 105 110 Val Gly Ala Met His Asp Asp Tyr Ala Thr Leu Leu His Arg Ala Gly 115 120 125 Ala Pro Val Gly Pro His Thr Ala Thr Gly Leu Gln Arg Ala Met Leu 130 135 140 Ala Asn Arg Leu Ser Tyr Val Leu Gly Thr Arg Gly Pro Ser Leu Ala 145 150 155 160 Val Asp Thr Ala Gln Ser Ser Ser Leu Val Ala Val Ala Leu Ala Val 165 170 175 Glu Ser Leu Arg Ala Gly Thr Ser Arg Val Ala Val Ala Gly Gly Val 180 185 190 Asn Leu Val Leu Ala Asp Glu Gly Thr Ala Ala Met Glu Arg Leu Gly 195 200 205 Ala Leu Ser Pro Asp Gly Arg Cys His Thr Phe Asp Ala Arg Ala Asn 210 215 220 Gly Tyr Val Arg Gly Glu Gly Gly Ala Ala Val Val Leu Lys Pro Leu 225 230 235 240 Ala Asp Ala Leu Ala Asp Gly Asp Pro Val Tyr Cys Val Val Arg Gly 245 250 255 Val Ala Val Gly Asn Asp Gly Gly Gly Pro Gly Leu Thr Ala Pro Asp 260 265 270 Arg Glu Gly Gln Glu Ala Val Leu Arg Ala Ala Cys Ala Gln Ala Arg 275 280 285 Val Asp Pro Ala Glu Val Arg Phe Val Glu Leu His Gly Thr Gly Thr 290 295 300 Pro Val Gly Asp Pro Val Glu Ala His Ala Leu Gly Ala Val His Gly 305 310 315 320 Ser Gly Arg Pro Ala Asp Asp Pro Leu Leu Val Gly Ser Val Lys Thr 325 330 335 Asn Ile Gly His Leu Glu Gly Ala Ala Gly Ile Ala Gly Leu Val Lys 340 345 350 Ala Ala Leu Cys Leu Arg Glu Arg Thr Leu Pro Gly Ser Leu Asn Phe 355 360 365 Ala Thr Pro Ser Pro Ala Ile Pro Leu Asp Gln Leu Arg Leu Lys Val 370 375 380 Gln Thr Ala Ala Ala Glu Leu Pro Leu Ala Pro Gly Gly Ala Pro Leu 385 390 395 400 Leu Ala Gly Val Ser Ser Phe Gly Ile Gly Gly Thr Asn Cys His Val 405 410 415 Val Leu Glu His Leu Pro Ser Arg Pro Thr Pro Ala Val Ser Val Ala 420 425 430 Ala Ser Leu Pro Asp Val Pro Pro Leu Leu Leu Ser Ala Arg Ser Glu 435 440 445 Gly Ala Leu Arg Ala Gln Ala Val Arg Leu Gly Glu Tyr Val Glu Arg 450 455 460 Val Gly Ala Asp Pro Arg Asp Val Ala Tyr Ser Leu Ala Ser Thr Arg 465 470 475 480 Thr Leu Phe Glu His Arg Ala Val Val Pro Cys Gly Gly Arg Gly Glu 485 490 495 Leu Val Ala Ala Leu Gly Gly Phe Ala Ala Gly Arg Val Ser Gly Gly 500 505 510 Val Arg Ser Gly Arg Ala Val Pro Gly Gly Val Gly Val Leu Phe Thr 515 520 525 Gly Gln Gly Ala Gln Trp Val Gly Met Gly Arg Gly Leu Tyr Ala Gly 530 535 540 Gly Gly Val Phe Ala Glu Val Leu Asp Glu Val Leu Ser Met Val Gly 545 550 555 560 Glu Val Asp Gly Arg Ser Leu Arg Asp Val Met Phe Gly Asp Val Asp 565 570 575 Val Asp Ala Gly Ala Gly Ala Asp Ala Gly Ala Gly Ala Gly Ala Gly 580 585 590 Val Gly Ser Gly Ser Gly Ser Val Gly Gly Leu Leu Gly Arg Thr Glu 595 600 605 Phe Ala Gln Pro Ala Leu Phe Ala Leu Glu Val Ala Leu Phe Arg Ala 610 615 620 Leu Glu Ala Arg Gly Val Glu Val Ser Val Val Leu Gly His Ser Val 625 630 635 640 Gly Glu Val Ala Ala Ala Tyr Val Ala Gly Val Leu Ser Leu Gly Asp 645 650 655 Ala Val Arg Leu Val Val Ala Arg Gly Gly Leu Met Gly Gly Leu Pro 660 665 670 Val Gly Gly Gly Met Trp Ser Val Gly Ala Ser Glu Ser Val Val Arg 675 680 685 Gly Val Val Glu Gly Leu Gly Glu Trp Val Ser Val Ala Ala Val Asn 690 695 700 Gly Pro Arg Ser Val Val Leu Ser Gly Asp Val Gly Val Leu Glu Ser 705 710 715 720 Val Val Ala Ser Leu Met Gly Asp Gly Val Glu Cys Arg Arg Leu Asp 725 730 735 Val Ser His Gly Phe His Ser Val Leu Met Glu Pro Val Leu Gly Glu 740 745 750 Phe Arg Gly Val Val Glu Ser Leu Glu Phe Gly Arg Val Arg Pro Gly 755 760 765 Val Val Val Val Ser Gly Val Ser Gly Gly Val Val Gly Ser Gly Glu 770 775 780 Leu Gly Asp Pro Gly Tyr Trp Val Arg His Ala Arg Glu Ala Val Arg 785 790 795 800 Phe Ala Asp Gly Val Gly Val Val Arg Gly Leu Gly Val Gly Thr Leu 805 810 815 Val Glu Val Gly Pro His Gly Val Leu Thr Gly Met Ala Gly Glu Cys 820 825 830 Leu Gly Ala Gly Asp Asp Val Val Val Val Pro Ala Met Arg Arg Gly 835 840 845 Arg Ala Glu Arg Glu Val Phe Glu Ala Ala Leu Ala Thr Val Phe Thr 850 855 860 Arg Asp Ala Gly Leu Asp Ala Thr Ala Leu His Thr Gly Ser Thr Gly 865 870 875 880 Arg Arg Ile Asp Leu Pro Thr Tyr Pro Phe Gln Arg Arg Thr His Trp 885 890 895 Ser Pro Ala Leu Ser Arg Pro Val Thr Ala Asp Ala Gly Ala Gly Val 900 905 910 Thr Ala Thr Asp Ala Val Gly His Ser Val Ser Pro Asp Pro Glu Ser 915 920 925 Thr Glu Gly Thr Ser His Arg Asp Thr Asp Asp Glu Ala Asp Ser Ala 930 935 940 Ser Pro Glu Pro Met Ser Pro Glu Asp Ala Val Arg Leu Val Arg Glu 945 950 955 960 Ser Thr Ala Ala Val Leu Gly His Asp Asp Pro Gly Glu Val Ala Leu 965 970 975 Asp Arg Thr Phe Thr Ser Gln Gly Met Asp Ser Val Thr Ala Val Glu 980 985 990 Leu Cys Asp Leu Leu Lys Gly Ala Ser Gly Leu Pro Leu Ala Ala Thr 995 1000 1005 Leu Val Tyr Asp Leu Pro Thr Pro Arg Ala Val Ala Glu His Ile Val 1010 1015 1020 Glu Ala Ala Gly Gly Pro Lys Asp Ser Val Ala Gly Gly Pro Gly Val 1025 1030 1035 1040 Leu Ser Ser Ala Ala Val Gly Val Ser Asp Ala Arg Gly Gly Ser Arg 1045 1050 1055 Asp Asp Asp Asp Pro Ile Ala Ile Val Gly Val Gly Cys Arg Leu Pro 1060 1065 1070 Gly Gly Val Asp Ser Arg Ala Ala Leu Trp Glu Leu Leu Glu Ser Gly 1075 1080 1085 Ala Asp Ala Ile Ser Ser Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp 1090 1095 1100 Gly Leu Tyr Asp Pro Glu Pro Gly Thr Pro Gly Lys Thr Tyr Val Arg 1105 1110 1115 1120 Glu Gly Gly Phe Leu His Ser Ala Ala Glu Phe Asp Ala Glu Phe Phe 1125 1130 1135 Gly Ile Ser Pro Arg Glu Ala Thr Ala Met Asp Pro Gln Gln Arg Leu 1140 1145 1150 Leu Leu Glu Ala Ser Trp Glu Ala Leu Glu Asp Ala Gly Val Leu Pro 1155 1160 1165 Glu Ser Leu Arg Gly Gly Asp Ala Gly Val Phe Val Gly Ala Thr Ala 1170 1175 1180 Pro Glu Tyr Gly Pro Arg Leu His Glu Gly Ala Asp Gly Tyr Glu Gly 1185 1190 1195 1200 Tyr Leu Leu Thr Gly Thr Thr Ala Ser Val Ala Ser Gly Arg Ile Ala 1205 1210 1215 Tyr Thr Leu Gly Thr Gly Gly Pro Ala Leu Thr Val Asp Thr Ala Cys 1220 1225 1230 Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Gln Ala Leu Arg Arg 1235 1240 1245 Gly Glu Cys Gly Leu Ala Leu Ala Gly Gly Ala Thr Val Met Ser Gly 1250 1255 1260 Pro Gly Met Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp 1265 1270 1275 1280 Gly Arg Cys Met Pro Phe Ser Ala Asp Ala Asp Gly Thr Ala Trp Ser 1285 1290 1295 Glu Gly Val Ala Val Leu Ala Leu Glu Arg Leu Ser Asp Ala Arg Arg 1300 1305 1310 Ala Gly His Arg Val Leu Gly Val Val Arg Gly Ser Ala Val Asn Gln 1315 1320 1325 Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Asn Arg Ser Ala Gln Glu 1330 1335 1340 Gly Val Ile Arg Ala Ala Leu Ala Asp Ala Gly Leu Ala Pro Gly Asp 1345 1350 1355 1360 Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro 1365 1370 1375 Ile Glu Ala Ser Ala Leu Leu Ala Thr Tyr Gly Arg Glu Arg Val Gly 1380 1385 1390 Asp Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Val Gly His Thr Gln 1395 1400 1405 Ala Ala Ala Gly Ala Ala Gly Val Val Lys Met Leu Leu Ala Leu Glu 1410 1415 1420 His Gly Thr Leu Pro Arg Thr Leu His Ala Asp Arg Pro Ser Thr His 1425 1430 1435 1440 Val Asp Trp Ser Ser Gly Thr Val Ala Leu Leu Ala Glu Ala Arg Arg 1445 1450 1455 Trp Pro Arg Arg Ser Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe 1460 1465 1470 Gly Ile Ser Gly Thr Asn Ala His Leu Ile Ile Glu Glu Ala Pro Glu 1475 1480 1485 Trp Val Glu Asp Ile Asp Gly Val Ala Ala Pro Asp Arg Gly Thr Ala 1490 1495 1500 Asp Ala Ala Ala Pro Ser Pro Leu Leu Leu Ser Ala Arg Ser Glu Gly 1505 1510 1515 1520 Ala Leu Arg Ala Gln Ala Val Arg Leu Gly Glu Tyr Val Glu Arg Val 1525 1530 1535 Gly Ala Asp Pro Arg Asp Val Ala Tyr Ser Leu Ala Ser Thr Arg Thr 1540 1545 1550 Leu Phe Glu His Arg Ala Val Val Pro Cys Gly Gly Arg Gly Glu Leu 1555 1560 1565 Val Ala Ala Leu Gly Gly Phe Ala Ala Gly Arg Val Ser Gly Gly Val 1570 1575 1580 Arg Ser Gly Arg Ala Val Pro Gly Gly Val Gly Val Leu Phe Thr Gly 1585 1590 1595 1600 Gln Gly Ala Gln Trp Val Gly Met Gly Arg Gly Leu Tyr Ala Gly Gly 1605 1610 1615 Gly Val Phe Ala Glu Val Leu Asp Glu Val Leu Ser Met Val Gly Glu 1620 1625 1630 Val Asp Gly Arg Ser Leu Arg Asp Val Met Phe Gly Asp Val Asp Val 1635 1640 1645 Asp Ala Gly Ala Gly Ala Asp Ala Gly Ala Gly Ala Gly Ala Gly Val 1650 1655 1660 Gly Ser Gly Ser Gly Ser Val Gly Gly Leu Leu Gly Arg Thr Glu Phe 1665 1670 1675 1680 Ala Gln Pro Ala Leu Phe Ala Leu Glu Val Ala Leu Phe Arg Ala Leu 1685 1690 1695 Glu Ala Arg Gly Val Glu Val Ser Val Val Leu Gly His Ser Val Gly 1700 1705 1710 Glu Val Ala Ala Ala Tyr Val Ala Gly Val Leu Ser Leu Gly Asp Ala 1715 1720 1725 Val Arg Leu Val Val Ala Arg Gly Gly Leu Met Gly Gly Leu Pro Val 1730 1735 1740 Gly Gly Gly Met Trp Ser Val Gly Ala Ser Glu Ser Val Val Arg Gly 1745 1750 1755 1760 Val Val Glu Gly Leu Gly Glu Trp Val Ser Val Ala Ala Val Asn Gly 1765 1770 1775 Pro Arg Ser Val Val Leu Ser Gly Asp Val Gly Val Leu Glu Ser Val 1780 1785 1790 Val Ala Ser Leu Met Gly Asp Gly Val Glu Cys Arg Arg Leu Asp Val 1795 1800 1805 Ser His Gly Phe His Ser Val Leu Met Glu Pro Val Leu Gly Glu Phe 1810 1815 1820 Arg Gly Val Val Glu Ser Leu Glu Phe Gly Arg Val Arg Pro Gly Val 1825 1830 1835 1840 Val Val Val Ser Gly Val Ser Gly Gly Val Val Gly Ser Gly Glu Leu 1845 1850 1855 Gly Asp Pro Gly Tyr Trp Val Arg His Ala Arg Glu Ala Val Arg Phe 1860 1865 1870 Ala Asp Gly Val Gly Val Val Arg Gly Leu Gly Val Gly Thr Leu Val 1875 1880 1885 Glu Val Gly Pro His Gly Val Leu Thr Gly Met Ala Gly Glu Cys Leu 1890 1895 1900 Gly Ala Gly Asp Asp Val Val Val Val Pro Ala Met Arg Arg Gly Arg 1905 1910 1915 1920 Ala Glu Arg Glu Val Phe Glu Ala Ala Leu Ala Thr Val Phe Thr Arg 1925 1930 1935 Asp Ala Gly Leu Asp Ala Thr Ala Leu His Thr Gly Ser Thr Gly Arg 1940 1945 1950 Arg Ile Asp Leu Pro Thr Tyr Pro Phe Gln Arg Asp Arg Tyr Trp Leu 1955 1960 1965 Asp Pro Val Arg Thr Ala Val Thr Gly Val Glu Pro Ala Gly Ser Pro 1970 1975 1980 Ala Asp Ala Arg Ala Thr Glu Arg Gly Arg Ser Thr Thr Ala Gly Ile 1985 1990 1995 2000 Arg Tyr Arg Val Ala Trp Gln Pro Ala Val Val Asp Arg Gly Asn Pro 2005 2010 2015 Gly Pro Ala Gly His Val Leu Leu Leu Ala Pro Asp Glu Asp Thr Ala 2020 2025 2030 Asp Ser Gly Leu Ala Pro Ala Ile Ala Arg Glu Leu Ala Val Arg Gly 2035 2040 2045 Ala Glu Val His Thr Val Ala Val Pro Val Gly Thr Gly Arg Glu Ala 2050 2055 2060 Ala Gly Asp Leu Leu Arg Ala Ala Gly Asp Gly Ala Ala Arg Ser Thr 2065 2070 2075 2080 Arg Val Leu Trp Leu Ala Pro Ala Glu Pro Asp Ala Ala Asp Ala Val 2085 2090 2095 Ala Leu Val Gln Ala Leu Gly Glu Ala Val Pro Glu Ala Pro Leu Trp 2100 2105 2110 Ile Thr Thr Arg Glu Ala Ala Ala Val Arg Pro Asp Glu Thr Pro Ser 2115 2120 2125 Val Gly Gly Ala Gln Leu Trp Gly Leu Gly Gln Val Ala Ala Leu Glu 2130 2135 2140 Leu Gly Arg Arg Trp Gly Gly Leu Ala Asp Leu Pro Gly Ser Ala Ser 2145 2150 2155 2160 Pro Ala Val Leu Arg Thr Phe Val Gly Ala Leu Leu Ala Gly Gly Glu 2165 2170 2175 Asn Gln Phe Ala Val Arg Pro Ser Gly Val His Val Arg Arg Val Val 2180 2185 2190 Pro Ala Pro Val Pro Val Pro Ala Ser Ala Arg Thr Val Thr Thr Ala 2195 2200 2205 Pro Ala Thr Ala Val Gly Glu Asp Ala Arg Asn Asp Thr Ser Asp Val 2210 2215 2220 Val Val Pro Asp Asp Arg Trp Ser Ser Gly Thr Val Leu Ile Thr Gly 2225 2230 2235 2240 Gly Thr Gly Ala Leu Gly Ala Gln Val Ala Arg Arg Leu Ala Arg Ser 2245 2250 2255 Gly Ala Ala Arg Leu Leu Leu Val Gly Arg Arg Gly Ala Ala Gly Pro 2260 2265 2270 Gly Val Gly Glu Leu Val Glu Glu Leu Thr Ala Leu Gly Ser Glu Val 2275 2280 2285 Ala Val Glu Ala Cys Asp Val Ala Asp Arg Asp Ala Leu Ala Ala Leu 2290 2295 2300 Leu Ala Gly Leu Pro Glu Glu Arg Pro Leu Val Ala Val Leu His Ala 2305 2310 2315 2320 Ala Gly Val Leu Asp Asp Gly Val Leu Asp Ser Leu Thr Ser Asp Arg 2325 2330 2335 Val Asp Ala Val Leu Arg Asp Lys Val Thr Ala Ala Arg His Leu Asp 2340 2345 2350 Glu Leu Thr Ala Asp Leu Pro Leu Asp Ala Phe Val Leu Phe Ser Ser 2355 2360 2365 Ile Val Gly Val Trp Gly Asn Gly Gly Gln Ala Val Tyr Ala Ala Ala 2370 2375 2380 Asn Ala Ala Leu Asp Ala Leu Ala Gln Arg Arg Arg Ala Arg Gly Ala 2385 2390 2395 2400 Arg Ala Ala Ser Ile Ala Trp Gly Pro Trp Ala Gly Ala Gly Met Ala 2405 2410 2415 Ser Gly Thr Ala Ala Lys Ser Phe Glu Arg Asp Gly Val Thr Ala Leu 2420 2425 2430 Asp Pro Glu Arg Ala Leu Asp Val Leu Asp Asp Val Val Gly Ala Gly 2435 2440 2445 Gly Thr Ser Ala Ala Gly Thr His Ala Ala Gly Glu Ser Ser Leu Leu 2450 2455 2460 Val Ala Asp Val Asp Trp Glu Thr Phe Val Gly Arg Ser Val Thr Arg 2465 2470 2475 2480 Arg Thr Trp Ser Leu Phe Asp Gly Val Ser Ala Ala Arg Ser Ala Arg 2485 2490 2495 Ala Gly His Ala Ala Asp Asp Arg Ala Ala Leu Thr Pro Gly Thr Arg 2500 2505 2510 Pro Gly Asp Gly Ala Pro Gly Gly Ser Gly Gln Asp Gly Gly Glu Gly 2515 2520 2525 Arg Pro Trp Leu Ser Val Gly Pro Ser Pro Ala Glu Arg Arg Arg Ala 2530 2535 2540 Leu Leu Thr Leu Val Arg Ser Glu Ala Ala Gly Ile Leu Arg His Ala 2545 2550 2555 2560 Ser Ala Asp Ala Val Asp Pro Glu Leu Ala Phe Arg Ser Ala Gly Phe 2565 2570 2575 Asp Ser Leu Thr Val Leu Glu Leu Arg Asn Arg Leu Thr Ala Ala Thr 2580 2585 2590 Gly Leu Asn Leu Pro Asn Thr Leu Leu Phe Asp His Pro Thr Pro Leu 2595 2600 2605 Ser Leu Ala Ser His Leu His Asp Glu Leu Phe Gly Pro Asp Ser Glu 2610 2615 2620 Ala Glu Pro Ala Ala Ala Ala Pro Thr Pro Val Met Ala Asp Glu Arg 2625 2630 2635 2640 Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val 2645 2650 2655 Ala Ser Pro Asp Asp Leu Trp Asp Leu Val Ala Gly Asp Gly His Thr 2660 2665 2670 Leu Ser Pro Phe Pro Ala Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr 2675 2680 2685 Asp Pro Glu Pro Gly Val Pro Gly Lys Ser Tyr Val Arg Glu Gly Gly 2690 2695 2700 Phe Leu Arg Ser Ala Ala Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser 2705 2710 2715 2720 Pro Arg Glu Ala Thr Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu 2725 2730 2735 Thr Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Val Pro Asp Ser Leu 2740 2745 2750 Arg Gly Thr Arg Thr Gly Val Phe Ser Gly Ile Ser Gln Gln Asp Tyr 2755 2760 2765 Ala Thr Gln Leu Gly Asp Ala Ala Asp Thr Tyr Gly Gly His Val Leu 2770 2775 2780 Thr Gly Thr Leu Gly Ser Val Ile Ser Gly Arg Val Ala Tyr Ala Leu 2785 2790 2795 2800 Gly Leu Glu Gly Pro Ala Leu Thr Val Asp Thr Ala Cys Ser Ser Ser 2805 2810 2815 Leu Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly Glu Cys 2820 2825 2830 Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro Thr Val 2835 2840 2845 Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys 2850 2855 2860 Lys Ala Phe Ala Glu Gly Ala Asp Gly Thr Ala Trp Ala Glu Gly Val 2865 2870 2875 2880 Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His 2885 2890 2895 Arg Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala 2900 2905 2910 Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala Gln Gln Arg Val Ile 2915 2920 2925 Arg Glu Ala Leu Ala Asp Ala Gly Leu Val Pro Ala Asp Val Asp Val 2930 2935 2940 Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala 2945 2950 2955 2960 Gly Ala Leu Leu Ala Thr Tyr Gly Arg Glu Arg Val Gly Asp Pro Leu 2965 2970 2975 Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ala 2980 2985 2990 Gly Val Gly Gly Val Ile Lys Val Val Gln Gly Met Arg His Gly Ser 2995 3000 3005 Leu Pro Arg Thr Leu His Val Asp Ala Pro Ser Ser Lys Val Glu Trp 3010 3015 3020 Ala Ser Gly Ala Val Glu Leu Leu Thr Glu Thr Arg Ser Trp Pro Arg 3025 3030 3035 3040 Arg Val Glu Arg Val Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser 3045 3050 3055 Gly Thr Asn Ala His Val Val Leu Glu Glu Ala Pro Ala Glu Ala Gly 3060 3065 3070 Ser Glu His Gly Asp Gly Pro Glu Pro Glu Arg Pro Asp Ala Val Thr 3075 3080 3085 Gly Pro Leu Ser Trp Val Leu Ser Ala Arg Ser Glu Gly Ala Leu Arg 3090 3095 3100 Ala Gln Ala Val Arg Leu Arg Glu Cys Val Glu Arg Val Gly Ala Asp 3105 3110 3115 3120 Pro Arg Asp Val Ala Gly Ser Leu Val Val Ser Arg Ala Ser Phe Gly 3125 3130 3135 Glu Arg Ala Val Val Val Gly Arg Gly Arg Glu Glu Leu Leu Ala Gly 3140 3145 3150 Leu Asp Val Val Ala Ala Gly Ala Pro Val Gly Val Ser Ser Gly Ala 3155 3160 3165 Gly Ala Val Val Arg Gly Ser Ala Val Arg Gly Arg Gly Val Gly Val 3170 3175 3180 Leu Phe Thr Gly Gln Gly Ala Gln Trp Val Gly Met Gly Arg Gly Leu 3185 3190 3195 3200 Tyr Ala Gly Gly Gly Val Phe Ala Glu Val Leu Asp Glu Val Leu Ser 3205 3210 3215 Val Val Gly Glu Val Asp Gly Arg Ser Leu Arg Asp Val Met Phe Ala 3220 3225 3230 Asp Ala Asp Ser Val Leu Gly Gly Leu Leu Gly Arg Thr Glu Phe Ala 3235 3240 3245 Gln Pro Ala Leu Phe Ala Leu Glu Val Ala Leu Phe Arg Ala Leu Glu 3250 3255 3260 Ala Arg Gly Val Glu Val Ser Val Val Leu Gly His Ser Val Gly Glu 3265 3270 3275 3280 Val Ala Ala Ala Tyr Val Ala Gly Val Leu Ser Leu Gly Asp Ala Val 3285 3290 3295 Arg Leu Val Val Ala Arg Gly Gly Leu Met Gly Gly Leu Pro Val Gly 3300 3305 3310 Gly Gly Met Trp Ser Val Gly Ala Ser Glu Ser Val Val Arg Gly Val 3315 3320 3325 Val Glu Gly Leu Gly Glu Trp Val Ser Val Ala Ala Val Asn Gly Pro 3330 3335 3340 Arg Ser Val Val Leu Ser Gly Asp Val Gly Val Leu Glu Ser Val Val 3345 3350 3355 3360 Val Thr Leu Met Gly Asp Gly Val Glu Cys Arg Arg Leu Asp Val Ser 3365 3370 3375 His Gly Phe His Ser Val Leu Met Glu Pro Val Leu Gly Glu Phe Arg 3380 3385 3390 Gly Val Val Glu Ser Leu Glu Phe Gly Arg Val Arg Pro Gly Val Val 3395 3400 3405 Val Val Ser Gly Val Ser Gly Gly Val Val Gly Ser Gly Glu Leu Gly 3410 3415 3420 Asp Pro Gly Tyr Trp Val Arg His Ala Arg Glu Ala Val Arg Phe Ala 3425 3430 3435 3440 Asp Gly Val Gly Val Val Arg Gly Leu Gly Val Gly Thr Leu Val Glu 3445 3450 3455 Val Gly Pro His Gly Val Leu Thr Gly Met Ala Gly Gln Cys Leu Glu 3460 3465 3470 Ala Gly Asp Asp Val Val Val Val Pro Ala Met Arg Arg Gly Arg Pro 3475 3480 3485 Glu Arg Glu Val Phe Glu Ala Ala Leu Ala Thr Val Phe Thr Arg Asp 3490 3495 3500 Ala Gly Leu Asp Ala Thr Thr Leu His Thr Gly Ser Thr Gly Arg Arg 3505 3510 3515 3520 Ile Asp Leu Pro Thr Tyr Pro Phe Gln His Asn Arg Tyr Trp Ala Thr 3525 3530 3535 Gly Ser Val Thr Gly Ala Thr Gly Thr Ser Ala Ala Ala Arg Phe Gly 3540 3545 3550 Leu Glu Trp Lys Asp His Pro Phe Leu Ser Gly Ala Thr Pro Ile Ala 3555 3560 3565 Gly Ser Gly Ala Leu Leu Leu Thr Gly Arg Val Gly Leu Ala Ala His 3570 3575 3580 Pro Trp Leu Ala Asp His Ala Ile Ser Gly Thr Val Leu Leu Pro Gly 3585 3590 3595 3600 Thr Ala Ile Ala Asp Leu Leu Leu Arg Ala Val Glu Glu Val Gly Ala 3605 3610 3615 Gly Gly Val Glu Glu Leu Thr Leu His Glu Pro Leu Leu Leu Pro Glu 3620 3625 3630 Arg Gly Gly Leu His Val Gln Val Leu Val Glu Ala Ala Asp Glu Gln 3635 3640 3645 Gly Arg Arg Ala Val Ala Val Ala Ala Arg Pro Glu Gly Pro Gly Arg 3650 3655 3660 Asp Gly Glu Glu Gln Glu Trp Thr Arg His Ala Glu Gly Val Leu Thr 3665 3670 3675 3680 Ser Thr Glu Thr Ala Val Pro Asp Met Gly Trp Ala Ala Gly Ala Trp 3685 3690 3695 Pro Pro Pro Gly Ala Glu Pro Ile Asp Val Glu Glu Leu Tyr Asp Ala 3700 3705 3710 Phe Ala Ala Asp Gly Tyr Gly Tyr Gly Pro Ala Phe Thr Ala Leu Ser 3715 3720 3725 Gly Val Trp Arg Leu Gly Asp Glu Leu Phe Ala Glu Val Arg Arg Pro 3730 3735 3740 Ala Gly Gly Ala Gly Thr Thr Gly Asp Gly Phe Gly Val His Pro Ala 3745 3750 3755 3760 Leu Phe Asp Ala Ala Leu His Pro Trp Arg Ala Gly Gly Leu Leu Pro 3765 3770 3775 Asp Thr Gly Gly Thr Thr Trp Ala Pro Phe Ser Trp Gln Gly Ile Ala 3780 3785 3790 Leu His Thr Thr Gly Ala Glu Thr Leu Arg Val Arg Leu Ala Pro Ala 3795 3800 3805 Ala Gly Gly Thr Glu Ser Ala Phe Ser Val Gln Ala Ala Asp Pro Ala 3810 3815 3820 Gly Thr Pro Val Leu Thr Leu Asp Ala Leu Leu Leu Arg Pro Val Thr 3825 3830 3835 3840 Leu Gly Arg Ala Asp Ala Pro Gln Pro Leu Tyr Arg Val Asp Trp Gln 3845 3850 3855 Pro Val Gly Gln Gly Thr Glu Ala Ser Gly Ala Gln Gly Trp Thr Val 3860 3865 3870 Leu Gly Gln Ala Ala Ala Glu Thr Val Ala Gln Pro Ala Ala His Ala 3875 3880 3885 Asp Leu Thr Ala Leu Arg Thr Ala Val Ala Ala Ala Gly Thr Pro Val 3890 3895 3900 Pro Arg Leu Val Val Val Ser Pro Val Asp Thr Arg Leu Asp Glu Gly 3905 3910 3915 3920 Pro Val Leu Ala Asp Ala Glu Ala Arg Ala Arg Ala Gly Asp Gly Trp 3925 3930 3935 Asp Asp Asp Pro Leu Arg Val Ala Leu Gly Arg Gly Leu Thr Leu Val 3940 3945 3950 Arg Glu Trp Val Glu Asp Glu Arg Leu Ala Asp Ser Arg Leu Val Val 3955 3960 3965 Leu Thr Arg Gly Ala Val Ala Ala Gly Pro Gly Asp Val Pro Asp Leu 3970 3975 3980 Thr Gly Ala Ala Leu Trp Gly Leu Leu Arg Ser Ala Gln Ser Glu Tyr 3985 3990 3995 4000 Pro Asp Arg Phe Thr Leu Ile Asp Val Asp Asp Ser Pro Glu Ser Arg 4005 4010 4015 Ala Ala Leu Pro Arg Ala Leu Gly Ser Ala Glu Arg Gln Leu Ala Leu 4020 4025 4030 Arg Thr Gly Asp Val Leu Ala Pro Ala Leu Val Pro Met Ala Thr Arg 4035 4040 4045 Pro Ala Glu Thr Thr Pro Ala Thr Ala Val Ala Ser Ala Thr Thr Gln 4050 4055 4060 Thr Gln Val Thr Ala Pro Ala Pro Asp Asp Pro Ala Ala Asp Ala Val 4065 4070 4075 4080 Phe Asp Pro Ala Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Ala Leu 4085 4090 4095 Gly Arg Arg Val Ala Ser His Leu Ala Arg Arg Tyr Gly Val Arg His 4100 4105 4110 Met Leu Leu Val Ser Arg Arg Gly Pro Asp Ala Pro Glu Ala Gly Pro 4115 4120 4125 Leu Glu Arg Glu Leu Ala Gly Leu Gly Val Thr Ala Thr Phe Leu Ala 4130 4135 4140 Cys Asp Leu Thr Asp Ile Glu Ala Val Arg Lys Ala Val Ala Ala Val 4145 4150 4155 4160 Pro Ser Asp His Pro Leu Thr Gly Val Val His Thr Ala Gly Val Leu 4165 4170 4175 Asp Asp Gly Ala Leu Thr Gly Leu Thr Arg Gln Arg Leu Asp Thr Val 4180 4185 4190 Leu Arg Pro Lys Ala Asp Ala Val Arg Asn Leu His Glu Ala Thr Leu 4195 4200 4205 Asp Arg Pro Leu Arg Ala Phe Val Leu Phe Ser Ala Ala Ala Gly Leu 4210 4215 4220 Leu Gly Arg Pro Gly Gln Ala Ser Tyr Ala Ala Ala Asn Ala Val Leu 4225 4230 4235 4240 Asp Ala Leu Ala Gly Ala Arg Arg Ala Ala Gly Leu Pro Ala Val Ser 4245 4250 4255 Leu Ala Trp Gly Leu Trp Asp Glu Gln Thr Gly Met Ala Gly Gly Leu 4260 4265 4270 Asp Glu Met Ala Leu Arg Val Leu Arg Arg Asp Gly Ile Ala Ala Met 4275 4280 4285 Pro Pro Glu Gln Gly Leu Glu Leu Leu Asp Leu Ala Leu Thr Gly His 4290 4295 4300 Arg Asp Gly Pro Ala Val Leu Val Pro Leu Leu Leu Asp Gly Ala Ala 4305 4310 4315 4320 Leu Arg Arg Thr Ala Lys Glu Arg Gly Ala Ala Thr Met Ser Pro Leu 4325 4330 4335 Leu Arg Ala Leu Leu Pro Ala Ala Leu Arg Arg Ser Gly Gly Ala Gly 4340 4345 4350 Ala Pro Ala Ala Ala Asp Arg His Gly Lys Glu Ala Asp Pro Gly Ala 4355 4360 4365 Gly Arg Leu Ala Gly Met Val Ala Leu Glu Ala Ala Glu Arg Ser Ala 4370 4375 4380 Ala Val Leu Glu Leu Val Thr Glu Gln Val Ala Glu Val Leu Gly Tyr 4385 4390 4395 4400 Ala Ser Ala Ala Glu Ile Glu Pro Glu Arg Pro Phe Arg Glu Ile Gly 4405 4410 4415 Val Asp Ser Leu Ala Ala Val Glu Leu Arg Asn Arg Leu Ser Arg Leu 4420 4425 4430 Val Gly Leu Arg Leu Pro Thr Thr Leu Ser Phe Asp His Pro Thr Pro 4435 4440 4445 Lys Asp Met Ala Gln His Ile Asp Gly Gln Leu Pro Arg Pro Ala Gly 4450 4455 4460 Ala Ser Pro Ala Asp Ala Ala Leu Glu Gly Ile Gly Asp Leu Ala Arg 4465 4470 4475 4480 Ala Val Ala Leu Leu Gly Thr Gly Asp Ala Arg Arg Ala Glu Val Arg 4485 4490 4495 Glu Gln Leu Val Gly Leu Leu Ala Ala Leu Asp Pro Pro Gly Arg Thr 4500 4505 4510 Gly Thr Ala Ala Pro Gly Val Pro Ser Gly Ala Asp Gly Ala Glu Pro 4515 4520 4525 Thr Val Thr Asp Arg Leu Asp Glu Ala Thr Asp Asp Glu Ile Phe Ala 4530 4535 4540 Phe Leu Asp Glu Gln Leu 4545 4550

【００４３】配列番号：９配列の長さ：１９９６アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Thr Ala Glu Asn Asp Lys Ile Arg Ser Tyr Leu Lys Arg Ala Thr 1 5 10 15 Ala Glu Leu His Arg Thr Lys Ser Arg Leu Ala Glu Val Glu Ser Ala 20 25 30 Ser Arg Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Tyr Pro Gly 35 40 45 Gly Val Ala Ser Pro Asp Asp Leu Trp Asp Leu Val Ala Ala Gly Thr 50 55 60 Asp Ala Val Ser Ala Phe Pro Val Asp Arg Gly Trp Asp Val Glu Gly 65 70 75 80 Leu Tyr Asp Pro Asp Pro Glu Ala Val Gly Arg Ser Tyr Val Arg Glu 85 90 95 Gly Gly Phe Leu His Ser Ala Ala Glu Phe Asp Ala Glu Phe Phe Gly 100 105 110 Ile Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu Leu 115 120 125 Leu Glu Thr Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Val Pro Ala 130 135 140 Ser Leu Arg Gly Thr Arg Thr Gly Val Phe Thr Gly Val Met Tyr Asp 145 150 155 160 Asp Tyr Gly Ser Arg Phe Asp Ser Ala Pro Pro Glu Tyr Glu Gly Tyr 165 170 175 Leu Val Asn Gly Ser Ala Gly Ser Ile Ala Ser Gly Arg Val Ala Tyr 180 185 190 Ala Leu Gly Leu Glu Gly Pro Ala Leu Thr Val Asp Thr Ala Cys Ser 195 200 205 Ser Ser Leu Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly 210 215 220 Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Thr Val Met Ala Thr Pro 225 230 235 240 Thr Val Leu Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp Gly 245 250 255 Arg Cys Lys Ala Phe Ala Glu Gly Ala Asp Gly Thr Ala Trp Ala Glu 260 265 270 Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Asn 275 280 285 Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp 290 295 300 Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala Gln Gln Arg 305 310 315 320 Val Ile Arg Glu Ala Leu Ala Asp Ala Gly Leu Thr Pro Ala Asp Val 325 330 335 Asp Ala Val Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile 340 345 350 Glu Ala Gly Ala Leu Leu Ala Thr Tyr Gly Ser Glu Arg Gln Gly Gln 355 360 365 Gly Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln 370 375 380 Ala Ala Ala Gly Val Gly Gly Val Ile Lys Val Val Gln Ala Met Arg 385 390 395 400 His Gly Ser Leu Pro Arg Thr Leu His Val Asp Ala Pro Ser Ser Lys 405 410 415 Val Glu Trp Ala Ser Gly Ala Val Glu Leu Leu Thr Glu Thr Arg Ser 420 425 430 Trp Pro Arg Arg Val Glu Arg Val Arg Arg Ala Ala Val Ser Ala Phe 435 440 445 Gly Val Ser Gly Thr Asn Ala His Val Val Leu Glu Glu Ala Pro Ala 450 455 460 Glu Ala Gly Ser Glu His Gly Asp Gly Pro Glu Pro Glu Arg Pro Asp 465 470 475 480 Ala Val Thr Gly Pro Leu Ser Trp Val Leu Ser Ala Arg Ser Glu Gly 485 490 495 Ala Leu Arg Ala Gln Ala Val Arg Leu Arg Glu Cys Val Glu Arg Val 500 505 510 Gly Ala Asp Pro Arg Asp Val Ala Gly Ser Leu Val Val Ser Arg Ala 515 520 525 Ser Phe Gly Glu Arg Ala Val Val Val Gly Arg Gly Arg Glu Glu Leu 530 535 540 Leu Ala Gly Leu Asp Val Val Ala Ala Gly Ala Pro Val Gly Val Ser 545 550 555 560 Gly Gly Val Ser Ser Gly Ala Gly Ala Val Val Arg Gly Ser Ala Val 565 570 575 Arg Gly Arg Gly Val Gly Val Leu Phe Thr Gly Gln Gly Ala Gln Trp 580 585 590 Val Gly Met Gly Arg Gly Leu Tyr Ala Gly Gly Gly Val Phe Ala Glu 595 600 605 Val Leu Asp Glu Val Leu Ser Val Val Gly Glu Val Gly Gly Trp Ser 610 615 620 Leu Arg Asp Val Met Phe Gly Asp Val Asp Val Asp Ala Gly Ala Gly 625 630 635 640 Ala Asp Ala Gly Val Gly Ser Gly Val Gly Val Gly Gly Leu Leu Gly 645 650 655 Arg Thr Glu Phe Ala Gln Pro Ala Leu Phe Ala Leu Glu Val Ala Leu 660 665 670 Phe Arg Ala Leu Glu Ala Arg Gly Val Glu Val Ser Val Val Leu Gly 675 680 685 His Ser Val Gly Glu Val Ala Ala Ala Tyr Val Ala Gly Val Leu Ser 690 695 700 Leu Gly Asp Ala Val Arg Leu Val Val Ala Arg Gly Gly Leu Met Gly 705 710 715 720 Gly Leu Pro Val Gly Gly Gly Met Trp Ser Val Gly Ala Ser Glu Ser 725 730 735 Val Val Arg Gly Val Val Glu Gly Leu Gly Glu Trp Val Ser Val Ala 740 745 750 Ala Val Asn Gly Pro Arg Ser Val Val Leu Ser Gly Asp Val Gly Val 755 760 765 Leu Glu Ser Val Val Ala Ser Leu Met Gly Asp Gly Val Glu Cys Arg 770 775 780 Arg Leu Asp Val Ser His Gly Phe His Ser Val Leu Met Glu Pro Val 785 790 795 800 Leu Gly Glu Phe Arg Gly Val Val Glu Ser Leu Glu Phe Gly Arg Val 805 810 815 Arg Pro Gly Val Val Val Val Ser Ser Val Ser Gly Gly Val Val Gly 820 825 830 Ser Gly Glu Leu Gly Asp Pro Gly Tyr Trp Val Arg His Ala Arg Glu 835 840 845 Ala Val Arg Phe Ala Asp Gly Val Gly Val Val Arg Gly Leu Gly Val 850 855 860 Gly Thr Leu Val Glu Val Gly Pro His Gly Val Leu Thr Gly Met Ala 865 870 875 880 Gly Glu Cys Leu Gly Ala Gly Asp Asp Val Val Val Val Pro Ala Met 885 890 895 Arg Arg Gly Arg Ala Glu Arg Glu Val Phe Glu Ala Ala Leu Ala Thr 900 905 910 Val Phe Thr Arg Asp Ala Gly Leu Asp Ala Thr Thr Leu His Thr Gly 915 920 925 Ser Thr Gly Arg Arg Ile Asp Leu Pro Thr Tyr Pro Phe Gln His Asp 930 935 940 Arg Tyr Trp Leu Ala Ala Pro Ser Arg Pro Arg Thr Asp Gly Leu Ser 945 950 955 960 Ala Ala Gly Leu Arg Glu Val Glu His Pro Leu Leu Thr Ala Ala Val 965 970 975 Glu Leu Pro Gly Thr Asp Thr Glu Val Trp Thr Gly Arg Ile Ser Ala 980 985 990 Ala Asp Leu Pro Trp Leu Ala Asp His Leu Val Trp Asp Arg Gly Val 995 1000 1005 Val Pro Gly Thr Ala Leu Leu Glu Thr Val Leu Gln Val Gly Ser Arg 1010 1015 1020 Ile Gly Leu Pro Arg Val Ala Glu Leu Val Leu Glu Thr Pro Leu Thr 1025 1030 1035 1040 Trp Thr Ser Asp Arg Pro Leu Gln Val Arg Ile Val Val Thr Ala Ala 1045 1050 1055 Ala Thr Ala Pro Gly Gly Ala Arg Glu Leu Thr Leu His Ser Arg Pro 1060 1065 1070 Glu Pro Val Ala Ala Ser Ser Ser Ser Pro Ser Pro Ala Ser Pro Arg 1075 1080 1085 His Leu Thr Ala Gln Glu Ser Asp Asp Asp Trp Thr Arg His Ala Ser 1090 1095 1100 Gly Leu Leu Ala Pro Ala Ala Gly Leu Ala Asp Asp Phe Ala Glu Leu 1105 1110 1115 1120 Thr Gly Ala Trp Pro Pro Val Gly Ala Glu Pro Leu Asp Leu Ala Gly 1125 1130 1135 Gln Tyr Pro Leu Phe Ala Ala Ala Gly Val Arg Tyr Glu Gly Ala Phe 1140 1145 1150 Arg Gly Leu Arg Ala Ala Trp Arg Arg Gly Asp Glu Val Phe Ala Asp 1155 1160 1165 Val Arg Leu Pro Asp Ala His Ala Val Asp Ala Asp Arg Tyr Gly Val 1170 1175 1180 His Pro Ala Leu Leu Asp Ala Val Leu His Pro Ile Ala Ser Leu Asp 1185 1190 1195 1200 Pro Leu Gly Asp Gly Gly His Gly Leu Leu Pro Phe Ser Trp Thr Asp 1205 1210 1215 Val Gln Gly His Gly Ala Gly Gly His Ala Leu Arg Val Arg Val Ala 1220 1225 1230 Ala Val Asp Gly Gly Ala Val Ser Val Thr Ala Ala Asp His Ala Gly 1235 1240 1245 Asn Pro Val Leu Ser Ala Arg Ser Leu Ala Leu Arg Arg Ile Thr Ala 1250 1255 1260 Asp Arg Leu Pro Ala Ala Pro Val Ala Pro Leu Tyr Arg Val Asp Trp 1265 1270 1275 1280 Leu Pro Phe Pro Gly Pro Val Pro Val Ser Ala Gly Gly Arg Trp Ala 1285 1290 1295 Val Val Gly Pro Glu Ala Glu Ala Thr Ala Ala Gly Leu Arg Ala Val 1300 1305 1310 Gly Leu Asp Val Arg Thr His Ala Leu Pro Leu Gly Glu Pro Leu Pro 1315 1320 1325 Pro Gln Ala Gly Thr Asp Ala Glu Val Ile Ile Leu Asp Leu Thr Thr 1330 1335 1340 Thr Ala Ala Gly Arg Thr Ala Ser Asp Gly Gly Arg Leu Ser Leu Leu 1345 1350 1355 1360 Asp Glu Val Arg Ala Thr Val Arg Arg Thr Leu Glu Ala Val Gln Ala 1365 1370 1375 Arg Leu Ala Asp Thr Glu Thr Ala Pro Asp Val Asp Val Arg Thr Ala 1380 1385 1390 Ala Arg Pro Arg Thr Ala Ala Arg Thr Ser Pro Arg Val Asp Thr Arg 1395 1400 1405 Thr Gly Ala Arg Thr Ala Asp Gly Pro Arg Leu Val Val Leu Thr Arg 1410 1415 1420 Gly Ala Ala Gly Pro Glu Gly Gly Ala Ala Asp Pro Ala Gly Ala Ala 1425 1430 1435 1440 Val Trp Gly Leu Val Arg Val Ala Gln Ala Glu Gln Pro Gly Arg Phe 1445 1450 1455 Thr Leu Val Asp Val Asp Gly Thr Gln Ala Ser Leu Arg Ala Leu Pro 1460 1465 1470 Gly Leu Leu Ala Thr Asp Ala Gly Gln Ser Ala Val Arg Asp Gly Arg 1475 1480 1485 Val Thr Val Pro Arg Leu Val Pro Val Ala Asp Pro Val Pro His Gly 1490 1495 1500 Gly Gly Thr Ala Ala Asp Gly Thr Gly Ala Gly Glu Pro Ser Ala Thr 1505 1510 1515 1520 Leu Asp Pro Glu Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Ala Leu 1525 1530 1535 Ala Ala Glu Thr Ala Arg His Leu Val Asp Arg His Lys Val Arg His 1540 1545 1550 Leu Leu Leu Val Gly Arg Arg Gly Pro Asp Ala Pro Gly Val Asp Arg 1555 1560 1565 Leu Val Ala Glu Leu Thr Glu Ser Gly Ala Glu Val Ala Val Arg Ala 1570 1575 1580 Cys Asp Val Thr Asp Arg Asp Ala Leu Arg Arg Leu Leu Asp Ala Leu 1585 1590 1595 1600 Pro Asp Glu His Pro Leu Thr Cys Val Val His Thr Ala Gly Val Leu 1605 1610 1615 Asp Asp Gly Val Leu Ser Ala Gln Thr Ala Glu Arg Ile Asp Thr Val 1620 1625 1630 Leu Arg Pro Lys Ala Asp Ala Ala Val His Leu Asp Glu Leu Thr Arg 1635 1640 1645 Glu Ile Gly Arg Val Pro Leu Val Leu Tyr Ser Ser Val Ser Ala Thr 1650 1655 1660 Leu Gly Ser Ala Gly Gln Ala Gly Tyr Ala Ala Ala Asn Ala Phe Met 1665 1670 1675 1680 Asp Ala Leu Ala Ala Arg Arg Cys Ala Ala Gly His Pro Ala Leu Ser 1685 1690 1695 Leu Gly Trp Gly Trp Trp Ser Gly Val Gly Leu Ala Thr Gly Leu Asp 1700 1705 1710 Gly Ala Asp Ala Ala Arg Val Arg Arg Ser Gly Leu Ala Pro Leu Asp 1715 1720 1725 Ala Gly Ala Ala Leu Asp Leu Leu Asp Arg Ala Leu Thr Arg Pro Glu 1730 1735 1740 Pro Ala Leu Leu Pro Val Arg Leu Asp Leu Arg Ala Ala Ala Gly Ala 1745 1750 1755 1760 Thr Ala Leu Pro Glu Val Leu Arg Asp Leu Ala Gly Val Pro Ala Asp 1765 1770 1775 Ala Arg Ser Thr Pro Gly Ala Ala Ala Gly Thr Gly Asp Glu Asp Gly 1780 1785 1790 Ala Val Arg Pro Ala Pro Ala Pro Ala Asp Ala Ala Gly Thr Leu Ala 1795 1800 1805 Ala Arg Leu Ala Gly Arg Ser Ala Pro Glu Arg Thr Ala Leu Leu Leu 1810 1815 1820 Asp Leu Val Arg Thr Glu Val Ala Ala Val Leu Gly His Gly Asp Pro 1825 1830 1835 1840 Ala Ala Ile Gly Ala Ala Arg Thr Phe Lys Asp Ala Gly Phe Asp Ser 1845 1850 1855 Leu Thr Ala Val Asp Leu Arg Asn Arg Leu Asn Thr Arg Thr Gly Leu 1860 1865 1870 Arg Leu Pro Ala Thr Leu Val Phe Asp His Pro Thr Pro Leu Ala Leu 1875 1880 1885 Ala Glu Leu Leu Leu Asp Gly Leu Glu Ala Ala Gly Pro Ala Glu Pro 1890 1895 1900 Ala Ala Glu Val Pro Asp Glu Ala Ala Gly Ala Glu Thr Leu Ser Gly 1905 1910 1915 1920 Val Ile Asp Arg Leu Glu Arg Ser Leu Ala Ala Thr Asp Asp Gly Asp 1925 1930 1935 Ala Arg Val Arg Ala Ala Arg Arg Leu Arg Gly Leu Leu Asp Ala Leu 1940 1945 1950 Pro Ala Gly Pro Gly Ala Ala Ser Gly Pro Asp Ala Gly Glu His Ala 1955 1960 1965 Pro Gly Arg Gly Asp Val Val Ile Asp Arg Leu Arg Ser Ala Ser Asp 1970 1975 1980 Asp Asp Leu Phe Asp Leu Leu Asp Ser Asp Phe Gln 1985 1990 1995

【００４４】配列番号：１０配列の長さ：３７２４アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Ser Ala Thr Asn Glu Glu Lys Leu Arg Glu Tyr Leu Arg Arg Ala 1 5 10 15 Met Ala Asp Leu His Ser Ala Arg Glu Arg Leu Arg Glu Val Glu Ser 20 25 30 Ala Ser Arg Glu Pro Ile Ala Ile Val Gly Met Ala Cys Arg Tyr Pro 35 40 45 Gly Gly Val Ala Ser Pro Glu Glu Leu Trp Asp Leu Val Ala Ala Gly 50 55 60 Thr Asp Ala Ile Ser Pro Phe Pro Val Asp Arg Gly Trp Asp Ala Glu 65 70 75 80 Gly Leu Tyr Asp Pro Glu Pro Gly Val Pro Gly Lys Ser Tyr Val Arg 85 90 95 Glu Gly Gly Phe Leu His Ser Ala Ala Glu Phe Asp Ala Glu Phe Phe 100 105 110 Gly Ile Ser Pro Arg Glu Ala Ala Ala Met Asp Pro Gln Gln Arg Leu 115 120 125 Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu Arg Ala Gly Ile Val Pro 130 135 140 Ala Ser Leu Arg Gly Thr Arg Thr Gly Val Phe Thr Gly Val Met Tyr 145 150 155 160 His Asp Tyr Gly Ser His Gln Val Gly Thr Ala Ala Asp Pro Ser Gly 165 170 175 Gln Leu Gly Leu Gly Thr Ala Gly Ser Val Ala Ser Gly Arg Val Ala 180 185 190 Tyr Thr Leu Gly Leu Gln Gly Pro Ala Val Thr Met Asp Thr Ala Cys 195 200 205 Ser Ser Ser Leu Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg 210 215 220 Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly Ala Thr Val Leu Ala Thr 225 230 235 240 Pro Thr Val Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Ala Asp 245 250 255 Gly Arg Cys Lys Ala Phe Ala Glu Gly Ala Asp Gly Thr Ala Trp Ala 260 265 270 Glu Gly Ala Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg Arg 275 280 285 Asn Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln 290 295 300 Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala Gln Gln 305 310 315 320 Arg Val Ile Arg Asp Ala Leu Ala Asp Ala Gly Leu Thr Pro Ala Asp 325 330 335 Val Asp Ala Val Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro 340 345 350 Ile Glu Ala Gly Ala Leu Met Ala Thr Tyr Gly Ser Glu Arg Val Gly 355 360 365 Asp Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln 370 375 380 Ala Ala Ala Gly Ala Ala Gly Val Ile Lys Met Val Gln Ala Leu Arg 385 390 395 400 Gln Ser Glu Leu Pro Arg Thr Leu His Val Asp Ala Pro Ser Ala Lys 405 410 415 Val Glu Trp Asp Ala Gly Ala Val Gln Leu Leu Thr Gly Val Arg Pro 420 425 430 Trp Pro Arg Arg Glu His Arg Pro Arg Arg Ala Ala Val Ser Ala Phe 435 440 445 Gly Val Ser Gly Thr Asn Ala His Val Ile Ile Glu Glu Pro Pro Ala 450 455 460 Ala Gly Asp Thr Ser Pro Ala Gly Asp Thr Pro Glu Pro Gly Glu Ala 465 470 475 480 Thr Ala Ser Pro Ser Thr Ala Ala Gly Pro Ser Ser Pro Ser Ala Val 485 490 495 Ala Gly Pro Leu Ser Pro Ser Ser Pro Ala Val Val Trp Pro Leu Ser 500 505 510 Ala Glu Thr Ala Pro Ala Leu Arg Ala Gln Ala Ala Arg Leu Arg Ala 515 520 525 His Leu Glu Arg Leu Pro Gly Thr Ser Pro Thr Asp Ile Gly His Ala 530 535 540 Leu Ala Ala Glu Arg Ala Ala Leu Thr Arg Arg Val Val Leu Leu Gly 545 550 555 560 Asp Asp Gly Ala Pro Val Asp Ala Leu Ala Ala Leu Ala Ala Gly Glu 565 570 575 Thr Thr Pro Asp Ala Val His Gly Thr Ala Ala Asp Ile Arg Arg Val 580 585 590 Ala Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Ala Gly Met Gly Ala 595 600 605 Glu Leu Leu Asp Thr Ala Pro Ala Phe Ala Ala Glu Leu Asp Arg Cys 610 615 620 Gln Gly Ala Leu Ser Pro Tyr Val Asp Trp Asn Leu Ala Asp Val Leu 625 630 635 640 Arg Gly Ala Pro Ala Ala Pro Gly Leu Asp Arg Val Asp Val Val Gln 645 650 655 Pro Ala Thr Phe Ala Val Met Val Gly Leu Ala Ala Leu Trp Arg Ser 660 665 670 Leu Gly Val Glu Pro Ala Ala Val Ile Gly His Ser Gln Gly Glu Ile 675 680 685 Ala Ala Ala Cys Val Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Arg 690 695 700 Ile Val Ala Leu Arg Ser Gln Val Ile Ala Arg Glu Leu Ala Gly Arg 705 710 715 720 Gly Gly Met Ala Ser Val Ala Leu Pro Ala Ala Glu Val Glu Ala Arg 725 730 735 Leu Ala Gly Gly Val Glu Ile Ala Ala Val Asn Gly Pro Gly Ser Thr 740 745 750 Val Val Cys Gly Glu Pro Gly Ala Leu Glu Ala Leu Leu Val Thr Leu 755 760 765 Glu Ser Glu Gly Thr Arg Val Arg Arg Ile Asp Val Asp Tyr Ala Ser 770 775 780 His Ser His Tyr Val Glu Ser Ile Arg Ala Glu Leu Ala Thr Val Leu 785 790 795 800 Gly Pro Val Arg Pro Arg Arg Gly Asp Val Pro Phe Tyr Ser Thr Val 805 810 815 Glu Ala Ala Leu Leu Asp Thr Ala Thr Leu Asp Ala Asp Tyr Trp Tyr 820 825 830 Arg Asn Leu Arg Leu Pro Val Arg Phe Glu Pro Thr Val Arg Ala Met 835 840 845 Leu Asp Asp Gly Val Asp Ala Phe Val Glu Cys Ser Ala His Pro Val 850 855 860 Leu Thr Val Gly Val Arg Gln Thr Val Glu Ser Ala Gly Gly Ala Val 865 870 875 880 Pro Ala Leu Ala Ser Leu Arg Arg Asp Glu Gly Gly Leu Arg Arg Phe 885 890 895 Leu Thr Ser Ala Ala Glu Ala Gln Val Val Gly Val Pro Val Asp Trp 900 905 910 Ala Thr Leu Arg Pro Gly Ala Gly Arg Val Asp Leu Pro Thr Tyr Ala 915 920 925 Phe Gln Arg Glu Arg His Trp Val Gly Pro Ala Arg Pro Asp Ser Ala 930 935 940 Ala Thr Ala Ala Thr Thr Gly Asp Asp Ala Pro Glu Pro Gly Asp Arg 945 950 955 960 Leu Gly Tyr His Val Ala Trp Lys Gly Leu Arg Ser Thr Thr Gly Gly 965 970 975 Trp Arg Pro Gly Leu Arg Leu Leu Ile Val Pro Thr Gly Asp Gln Tyr 980 985 990 Thr Ala Leu Ala Asp Thr Leu Glu Gln Ala Val Ala Ser Phe Gly Gly 995 1000 1005 Thr Val Arg Arg Val Ala Phe Asp Pro Ala Arg Thr Gly Arg Ala Glu 1010 1015 1020 Leu Phe Gly Leu Leu Glu Thr Glu Ile Asn Gly Asp Thr Ala Val Thr 1025 1030 1035 1040 Gly Val Val Ser Leu Leu Gly Leu Cys Thr Asp Gly Arg Pro Asp His 1045 1050 1055 Pro Ala Val Pro Val Ala Val Thr Ala Thr Leu Ala Leu Val Gln Ala 1060 1065 1070 Leu Ala Asp Leu Gly Ser Thr Ala Pro Leu Trp Thr Val Thr Cys Gly 1075 1080 1085 Ala Val Ala Thr Ala Pro Asp Glu Leu Pro Cys Thr Ala Gly Ala Gln 1090 1095 1100 Leu Trp Gly Leu Gly Arg Val Ala Ala Leu Glu Leu Pro Glu Val Trp 1105 1110 1115 1120 Gly Gly Leu Ile Asp Leu Pro Ala Arg Pro Asp Ala Arg Val Leu Asp 1125 1130 1135 Arg Leu Ala Gly Val Leu Ala Glu Pro Gly Gly Glu Asp Gln Ile Ala 1140 1145 1150 Val Arg Met Ala Gly Val Phe Gly Arg Arg Val Leu Arg Asn Pro Ala 1155 1160 1165 Asp Ser Arg Pro Pro Ala Trp Arg Ala Arg Gly Thr Val Leu Ile Ala 1170 1175 1180 Gly Asp Leu Thr Thr Val Pro Gly Arg Leu Val Arg Ser Leu Leu Glu 1185 1190 1195 1200 Asp Gly Ala Asp Arg Val Val Leu Ala Gly Pro Asp Ala Pro Ala Gln 1205 1210 1215 Ala Ala Ala Ala Gly Leu Thr Gly Val Ser Leu Val Pro Val Arg Cys 1220 1225 1230 Asp Val Thr Asp Arg Ala Ala Leu Ala Ala Leu Leu Asp Glu His Ala 1235 1240 1245 Pro Thr Val Ala Val His Ala Pro Pro Leu Val Pro Leu Ala Pro Leu 1250 1255 1260 Arg Glu Thr Ala Pro Gly Asp Ile Ala Ala Ala Leu Ala Ala Lys Thr 1265 1270 1275 1280 Thr Ala Ala Gly His Leu Val Asp Leu Ala Pro Ala Ala Gly Leu Asp 1285 1290 1295 Ala Leu Val Leu Phe Ser Ser Val Ser Gly Val Trp Gly Gly Ala Ala 1300 1305 1310 Gln Gly Gly Tyr Ala Ala Ala Ser Ala His Leu Asp Ala Leu Ala Glu 1315 1320 1325 Arg Ala Arg Ala Ala Gly Val Pro Ala Phe Ser Val Ala Trp Ser Pro 1330 1335 1340 Trp Ala Gly Gly Thr Pro Ala Asp Gly Ala Glu Ala Glu Phe Leu Ser 1345 1350 1355 1360 Arg Arg Gly Leu Ala Pro Leu Asp Pro Asp Gln Ala Val Arg Thr Leu 1365 1370 1375 Arg Arg Met Leu Glu Arg Gly Ser Ala Cys Gly Ala Val Ala Asp Val 1380 1385 1390 Glu Trp Ser Arg Phe Ala Ala Ser Tyr Thr Trp Val Arg Pro Ala Val 1395 1400 1405 Leu Phe Asp Asp Ile Pro Asp Val Gln Arg Leu Arg Ala Ala Glu Leu 1410 1415 1420 Ala Pro Ser Thr Gly Asp Ser Thr Thr Ser Glu Leu Val Arg Glu Leu 1425 1430 1435 1440 Thr Ala Gln Ser Gly His Lys Arg His Ala Thr Leu Leu Arg Leu Val 1445 1450 1455 Arg Ala His Ala Ala Ala Val Leu Gly Gln Ser Ser Gly Asp Ala Val 1460 1465 1470 Ser Ser Ala Arg Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu Thr Ala 1475 1480 1485 Leu Glu Leu Arg Asp Arg Leu Ser Thr Ser Thr Gly Leu Lys Leu Pro 1490 1495 1500 Thr Ser Leu Val Phe Asp His Ser Ser Pro Ala Ala Leu Ala Arg His 1505 1510 1515 1520 Leu Gly Glu Glu Leu Leu Gly Arg Asn Asp Thr Ala Asp Arg Ala Gly 1525 1530 1535 Pro Asp Thr Pro Val Arg Thr Asp Glu Pro Ile Ala Ile Ile Gly Met 1540 1545 1550 Ala Cys Arg Leu Pro Gly Gly Val Gln Ser Pro Glu Asp Leu Trp Asp 1555 1560 1565 Leu Leu Thr Gly Gly Thr Asp Ala Ile Thr Pro Phe Pro Thr Asn Arg 1570 1575 1580 Gly Trp Asp Asn Glu Thr Leu Tyr Asp Pro Asp Pro Asp Ser Pro Gly 1585 1590 1595 1600 His His Thr Tyr Val Arg Glu Gly Gly Phe Leu His Asp Ala Ala Glu 1605 1610 1615 Phe Asp Pro Gly Phe Phe Gly Ile Ser Pro Arg Glu Ala Leu Ala Met 1620 1625 1630 Asp Pro Gln Gln Arg Leu Ile Leu Glu Thr Ser Trp Glu Ser Phe Glu 1635 1640 1645 Arg Ala Gly Ile Asp Pro Val Glu Leu Arg Gly Ser Arg Thr Gly Val 1650 1655 1660 Phe Val Gly Thr Asn Gly Gln His Tyr Val Pro Leu Leu Gln Asp Gly 1665 1670 1675 1680 Asp Glu Asn Phe Asp Gly Tyr Ile Ala Thr Gly Asn Ser Ala Ser Val 1685 1690 1695 Met Ser Gly Arg Leu Ser Tyr Val Phe Gly Leu Glu Gly Pro Ala Val 1700 1705 1710 Thr Val Asp Thr Ala Cys Ser Ala Ser Leu Ala Ala Leu His Leu Ala 1715 1720 1725 Val Gln Ser Leu Arg Arg Gly Glu Cys Asp Tyr Ala Leu Ala Gly Gly 1730 1735 1740 Ala Thr Val Met Ser Thr Pro Glu Met Leu Val Glu Phe Ala Arg Gln 1745 1750 1755 1760 Arg Ala Val Ser Pro Asp Gly Arg Ser Lys Ala Phe Ala Glu Ala Ala 1765 1770 1775 Asp Gly Val Gly Leu Ala Glu Gly Ala Gly Met Leu Leu Val Glu Arg 1780 1785 1790 Leu Ser Glu Ala Gln Lys Lys Gly His Pro Val Leu Ala Val Val Arg 1795 1800 1805 Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 1810 1815 1820 Ser Gly Pro Ala Gln Gln Arg Val Ile Arg Glu Ala Leu Ala Asp Ala 1825 1830 1835 1840 Gly Leu Thr Pro Ala Asp Val Asp Ala Val Glu Ala His Gly Thr Gly 1845 1850 1855 Thr Pro Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu Leu Ala Thr Tyr 1860 1865 1870 Gly Arg Asp Arg Arg Asp Gly Pro Leu Trp Leu Gly Ser Leu Lys Ser 1875 1880 1885 Asn Ile Gly His Thr Gln Ala Ala Ala Gly Val Ala Gly Val Ile Lys 1890 1895 1900 Met Val Leu Ala Leu Arg His Gly Glu Leu Pro Arg Thr Leu His Ala 1905 1910 1915 1920 Ser Thr Ala Ser Ser Arg Ile Asp Trp Asp Ala Gly Ala Val Glu Leu 1925 1930 1935 Leu Asp Glu Ala Arg Pro Trp Leu Gln Arg Ala Glu Gly Pro Arg Arg 1940 1945 1950 Ala Gly Ile Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala His Leu Val 1955 1960 1965 Ile Glu Glu Pro Pro Glu Pro Thr Ala Pro Glu Leu Leu Ala Pro Glu 1970 1975 1980 Pro Ala Ala Asp Gly Asp Val Trp Ser Glu Glu Trp Trp His Glu Val 1985 1990 1995 2000 Thr Val Pro Leu Met Met Ser Ala His Asn Glu Ala Ala Leu Arg Asp 2005 2010 2015 Gln Ala Arg Arg Leu Arg Ala Asp Leu Leu Ala His Pro Glu Leu His 2020 2025 2030 Pro Ala Asp Val Gly Tyr Thr Leu Ile Thr Thr Arg Thr Arg Phe Glu 2035 2040 2045 Gln Arg Ala Ala Val Val Gly Glu Asn Phe Thr Glu Leu Ile Ala Ala 2050 2055 2060 Leu Asp Asp Leu Val Glu Gly Arg Pro His Pro Leu Val Leu Arg Gly 2065 2070 2075 2080 Thr Ala Gly Thr Ser Asp Gln Val Val Phe Val Phe Pro Gly Gln Gly 2085 2090 2095 Ser Gln Trp Pro Glu Met Ala Asp Gly Leu Leu Ala Arg Ser Ser Gly 2100 2105 2110 Ser Gly Ser Phe Leu Glu Thr Ala Arg Ala Cys Asp Leu Ala Leu Arg 2115 2120 2125 Pro His Leu Gly Trp Ser Val Leu Asp Val Leu Arg Arg Glu Pro Gly 2130 2135 2140 Ala Pro Ser Leu Asp Arg Val Asp Val Val Gln Pro Val Leu Phe Thr 2145 2150 2155 2160 Met Met Val Ser Leu Ala Glu Thr Trp Arg Ser Leu Gly Val Glu Pro 2165 2170 2175 Ala Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Tyr Val 2180 2185 2190 Ala Gly Ala Leu Thr Leu Asp Asp Ala Ala Arg Ile Val Ala Leu Arg 2195 2200 2205 Ser Gln Ala Trp Leu Arg Leu Ala Gly Lys Gly Gly Met Val Ala Val 2210 2215 2220 Thr Leu Ser Glu Arg Asp Leu Arg Pro Arg Leu Glu Pro Trp Ser Asp 2225 2230 2235 2240 Arg Leu Ala Val Ala Ala Val Asn Gly Pro Glu Thr Cys Ala Val Ser 2245 2250 2255 Gly Asp Pro Asp Ala Leu Ala Glu Leu Val Ala Glu Leu Gly Ala Glu 2260 2265 2270 Gly Val His Ala Arg Pro Ile Pro Gly Val Asp Thr Ala Gly His Ser 2275 2280 2285 Pro Gln Val Asp Thr Leu Glu Ala His Leu Arg Lys Val Leu Ala Pro 2290 2295 2300 Val Ala Pro Arg Thr Ser Asp Ile Pro Phe Tyr Ser Thr Val Thr Gly 2305 2310 2315 2320 Gly Leu Ile Asp Thr Ala Glu Leu Asp Ala Asp Tyr Trp Tyr Arg Asn 2325 2330 2335 Met Arg Glu Pro Val Glu Phe Glu Gln Ala Thr Arg Ala Leu Ile Ala 2340 2345 2350 Asp Gly His Asp Val Phe Leu Glu Ser Ser Pro His Pro Met Leu Ala 2355 2360 2365 Val Ser Leu Gln Glu Thr Ile Ser Asp Ala Gly Ser Pro Ala Ala Val 2370 2375 2380 Leu Gly Thr Leu Arg Arg Gly Gln Gly Gly Pro Arg Trp Leu Gly Val 2385 2390 2395 2400 Ala Leu Cys Arg Ala Tyr Thr His Gly Leu Glu Ile Asp Ala Glu Ala 2405 2410 2415 Ile Phe Gly Pro Asp Ser Arg Gln Val Glu Leu Pro Thr Tyr Pro Phe 2420 2425 2430 Gln Arg Glu Arg Tyr Trp Tyr Ser Pro Gly His Arg Gly Asp Asp Pro 2435 2440 2445 Ala Ser Leu Gly Leu Asp Ala Val Asp His Pro Leu Leu Gly Ser Gly 2450 2455 2460 Val Glu Leu Pro Glu Ser Gly Asp Arg Met Tyr Thr Ala Arg Leu Gly 2465 2470 2475 2480 Ala Asp Thr Thr Pro Trp Leu Ala Asp His Ala Leu Leu Gly Ser Pro 2485 2490 2495 Leu Leu Pro Gly Ala Ala Phe Ala Asp Leu Ala Leu Trp Ala Gly Arg 2500 2505 2510 Gln Ala Gly Thr Gly Arg Val Glu Glu Leu Thr Leu Ala Ala Pro Leu 2515 2520 2525 Val Leu Pro Gly Ser Gly Gly Val Arg Leu Arg Leu Asn Val Gly Ala 2530 2535 2540 Pro Gly Thr Asp Asp Ala Arg Arg Phe Ala Val His Ala Arg Ala Glu 2545 2550 2555 2560 Gly Ala Thr Asp Trp Thr Leu His Ala Glu Gly Leu Leu Thr Ala Gln 2565 2570 2575 Asp Thr Ala Asp Ala Pro Asp Ala Ser Ala Ala Thr Pro Pro Pro Gly 2580 2585 2590 Ala Glu Gln Leu Asp Ile Gly Asp Phe Tyr Gln Arg Phe Ser Glu Leu 2595 2600 2605 Gly Tyr Gly Tyr Gly Pro Phe Phe Arg Gly Leu Val Ser Ala His Arg 2610 2615 2620 Cys Gly Pro Asp Ile His Ala Glu Val Ala Leu Pro Val Gln Ala Gln 2625 2630 2635 2640 Gly Asp Ala Ala Arg Phe Gly Ile His Pro Ala Leu Leu Asp Ala Ala 2645 2650 2655 Leu Gln Thr Met Ser Leu Gly Gly Phe Phe Pro Glu Asp Gly Arg Val 2660 2665 2670 Arg Met Pro Phe Ala Leu Arg Gly Val Arg Leu Tyr Arg Ala Gly Ala 2675 2680 2685 Asp Arg Leu His Val Arg Val Ser Pro Val Ser Glu Asp Ala Val Arg 2690 2695 2700 Ile Arg Cys Ala Asp Gly Glu Gly Arg Pro Val Ala Glu Ile Glu Ser 2705 2710 2715 2720 Phe Ile Met Arg Pro Val Asp Pro Gly Gln Leu Leu Gly Gly Arg Pro 2725 2730 2735 Val Gly Ala Asp Ala Leu Phe Arg Ile Ala Trp Arg Glu Leu Ala Ala 2740 2745 2750 Gly Pro Gly Thr Arg Thr Gly Asp Gly Thr Pro Pro Pro Val Arg Trp 2755 2760 2765 Val Leu Ala Gly Pro Asp Ala Leu Gly Leu Ala Glu Ala Ala Asp Ala 2770 2775 2780 His Leu Pro Ala Val Pro Gly Pro Asp Gly Ala Leu Pro Ser Pro Thr 2785 2790 2795 2800 Gly Arg Pro Ala Pro Asp Ala Val Val Phe Ala Val Arg Ala Gly Thr 2805 2810 2815 Gly Asp Val Ala Ala Asp Ala His Thr Val Ala Cys Arg Val Leu Asp 2820 2825 2830 Leu Val Gln Arg Arg Leu Ala Ala Pro Glu Gly Pro Asp Gly Ala Arg 2835 2840 2845 Leu Val Val Ala Thr Arg Gly Ala Val Ala Val Arg Asp Asp Ala Glu 2850 2855 2860 Val Asp Asp Pro Ala Ala Ala Ala Ala Trp Gly Leu Leu Arg Ser Ala 2865 2870 2875 2880 Gln Ala Glu Glu Pro Gly Arg Phe Leu Leu Val Asp Leu Asp Asp Asp 2885 2890 2895 Pro Ala Ser Ala Arg Ala Leu Thr Asp Ala Leu Ala Ser Gly Glu Pro 2900 2905 2910 Gln Thr Ala Val Arg Ala Gly Thr Val Tyr Val Pro Arg Leu Glu Arg 2915 2920 2925 Ala Ala Asp Arg Thr Asp Gly Pro Leu Thr Pro Pro Asp Asp Gly Ala 2930 2935 2940 Trp Arg Leu Gly Arg Gly Thr Asp Leu Thr Leu Asp Gly Leu Ala Leu 2945 2950 2955 2960 Val Pro Ala Pro Asp Ala Glu Ala Pro Leu Glu Pro Gly Gln Val Arg 2965 2970 2975 Val Ala Val Arg Ala Ala Gly Val Asn Phe Arg Asp Ala Leu Ile Ala 2980 2985 2990 Leu Gly Met Tyr Pro Gly Glu Ala Glu Met Gly Thr Glu Gly Ala Gly 2995 3000 3005 Thr Val Val Glu Val Gly Pro Gly Val Thr Gly Val Ala Val Gly Asp 3010 3015 3020 Arg Val Leu Gly Leu Trp Asp Gly Gly Leu Gly Pro Leu Cys Val Ala 3025 3030 3035 3040 Asp His Arg Leu Leu Ala Pro Val Pro Asp Gly Trp Ser Tyr Ala Gln 3045 3050 3055 Ala Ala Ser Val Pro Ala Val Phe Leu Ser Ala Tyr Tyr Gly Leu Val 3060 3065 3070 Thr Leu Ala Gly Leu Arg Pro Gly Glu Arg Val Leu Val His Ala Ala 3075 3080 3085 Ala Gly Gly Val Gly Met Ala Ala Val Gln Ile Ala Arg His Leu Gly 3090 3095 3100 Ala Glu Val Leu Ala Thr Ala Ser Pro Gly Lys Trp Asp Ala Leu Arg 3105 3110 3115 3120 Ala Met Gly Ile Thr Asp Asp His Leu Ala Ser Ser Arg Thr Leu Asp 3125 3130 3135 Phe Ala Thr Ala Phe Thr Gly Ala Asp Gly Thr Ser Arg Ala Asp Val 3140 3145 3150 Val Leu Asn Ser Leu Thr Lys Glu Phe Val Asp Ala Ser Leu Gly Leu 3155 3160 3165 Leu Arg Pro Gly Gly Arg Phe Leu Glu Leu Gly Lys Thr Asp Val Arg 3170 3175 3180 Asp Pro Glu Arg Ile Ala Ala Glu His Pro Gly Val Arg Tyr Arg Ala 3185 3190 3195 3200 Phe Asp Leu Asn Glu Ala Gly Pro Asp Ala Leu Gly Arg Leu Leu Arg 3205 3210 3215 Glu Leu Met Asp Leu Phe Ala Ala Gly Val Leu His Pro Leu Pro Val 3220 3225 3230 Val Thr His Asp Val Arg Arg Ala Ala Asp Ala Leu Arg Thr Ile Ser 3235 3240 3245 Gln Ala Arg His Thr Gly Lys Leu Val Leu Thr Met Pro Pro Ala Trp 3250 3255 3260 His Pro Tyr Gly Thr Val Leu Val Thr Gly Gly Thr Gly Ala Leu Gly 3265 3270 3275 3280 Ser Arg Ile Ala Arg His Leu Ala Ser Arg His Gly Val Arg Arg Leu 3285 3290 3295 Leu Ile Ala Ala Arg Arg Gly Pro Asp Gly Glu Gly Ala Ala Glu Leu 3300 3305 3310 Val Ala Asp Leu Ala Ala Leu Gly Ala Ser Ala Thr Val Val Ala Cys 3315 3320 3325 Asp Val Ser Asp Ala Asp Ala Val Arg Gly Leu Leu Ala Gly Ile Pro 3330 3335 3340 Ala Asp His Pro Leu Thr Ala Val Val His Ser Thr Gly Val Leu Asp 3345 3350 3355 3360 Asp Gly Val Leu Pro Gly Leu Thr Pro Glu Arg Met Arg Arg Val Leu 3365 3370 3375 Arg Pro Lys Val Glu Ala Ala Val His Leu Asp Glu Leu Thr Arg Asp 3380 3385 3390 Leu Asp Leu Ser Ala Phe Val Leu Phe Ser Ser Ser Ala Gly Leu Leu 3395 3400 3405 Gly Ser Pro Ala Gln Gly Asn Tyr Ala Ala Ala Asn Ala Thr Leu Asp 3410 3415 3420 Ala Leu Ala Ala Arg Arg Arg Ser Leu Gly Leu Pro Ser Val Ser Leu 3425 3430 3435 3440 Ala Trp Gly Leu Trp Ser Asp Thr Ser Arg Met Ala His Ala Leu Asp 3445 3450 3455 Gln Glu Ser Leu Gln Arg Arg Phe Ala Arg Ser Gly Phe Pro Pro Leu 3460 3465 3470 Ser Ala Thr Leu Gly Ala Ala Leu Phe Asp Ala Ala Leu Arg Val Asp 3475 3480 3485 Glu Ala Val Gln Val Pro Met Arg Phe Asp Pro Ala Ala Leu Arg Ala 3490 3495 3500 Thr Gly Ser Val Pro Ala Leu Leu Ser Asp Leu Val Gly Ser Ala Pro 3505 3510 3515 3520 Ala Thr Gly Ser Ala Ala Pro Ala Ser Gly Pro Leu Pro Ala Pro Asp 3525 3530 3535 Ala Gly Thr Val Gly Glu Pro Leu Ala Glu Arg Leu Ala Gly Leu Ser 3540 3545 3550 Ala Glu Glu Arg His Asp Arg Leu Leu Gly Leu Val Gly Glu His Val 3555 3560 3565 Ala Ala Val Leu Gly His Gly Ser Ala Ala Glu Val Arg Pro Asp Arg 3570 3575 3580 Pro Phe Arg Glu Val Gly Phe Asp Ser Leu Thr Ala Val Glu Leu Arg 3585 3590 3595 3600 Asn Arg Met Ala Ala Val Thr Gly Val Arg Leu Pro Ala Thr Leu Val 3605 3610 3615 Phe Asp His Pro Thr Pro Ala Ala Leu Ser Ser His Leu Asp Gly Leu 3620 3625 3630 Leu Ala Pro Ala Gln Pro Val Thr Thr Thr Pro Leu Leu Ser Glu Leu 3635 3640 3645 Asp Arg Ile Glu Glu Ala Leu Ala Ala Leu Thr Pro Glu His Leu Ala 3650 3655 3660 Glu Leu Ala Pro Ala Pro Asp Asp Arg Ala Glu Val Ala Leu Arg Leu 3665 3670 3675 3680 Asp Ala Leu Ala Asp Arg Trp Arg Ala Leu His Asp Gly Ala Pro Gly 3685 3690 3695 Ala Asp Asp Asp Ile Thr Asp Val Leu Ser Ser Ala Asp Asp Asp Glu 3700 3705 3710 Ile Phe Ala Phe Ile Asp Glu Arg Tyr Gly Thr Ser 3715 3720

【００４５】配列番号：１１配列の長さ：１５８０アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Ala Asn Glu Glu Lys Leu Arg Ala Tyr Leu Lys Arg Val Thr Gly 1 5 10 15 Glu Leu His Arg Ala Thr Glu Gln Leu Arg Ala Leu Asp Arg Arg Ala 20 25 30 His Glu Pro Ile Ala Ile Val Gly Ala Ala Cys Arg Leu Pro Gly Gly 35 40 45 Val Glu Ser Pro Asp Asp Leu Trp Glu Leu Leu His Ala Gly Ala Asp 50 55 60 Ala Val Gly Pro Ala Pro Ala Asp Arg Gly Trp Asp Val Glu Gly Arg 65 70 75 80 Tyr Ser Pro Asp Pro Asp Thr Pro Gly Thr Ser Tyr Cys Arg Glu Gly 85 90 95 Gly Phe Val Gln Gly Ala Asp Arg Phe Asp Pro Ala Leu Phe Gly Ile 100 105 110 Ser Pro Asn Glu Ala Leu Thr Met Asp Pro Gln Gln Arg Leu Leu Leu 115 120 125 Glu Thr Ser Trp Glu Ala Leu Glu Arg Ala Gly Leu Asp Pro Gln Ser 130 135 140 Leu Ala Gly Ser Arg Thr Gly Val Phe Ala Gly Ala Trp Glu Ser Gly 145 150 155 160 Tyr Gln Lys Gly Val Glu Gly Leu Glu Ala Asp Leu Glu Ala Gln Leu 165 170 175 Leu Ala Gly Ile Val Ser Phe Thr Ala Gly Arg Val Ala Tyr Ala Leu 180 185 190 Gly Leu Glu Gly Pro Ala Leu Thr Ile Asp Thr Ala Cys Ser Ser Ser 195 200 205 Leu Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly Glu Cys 210 215 220 Asp Leu Ala Leu Ala Gly Gly Ala Thr Val Ile Ala Asp Phe Ala Leu 225 230 235 240 Phe Thr Gln Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys 245 250 255 Lys Ala Phe Gly Glu Thr Ala Asp Gly Phe Gly Pro Ala Glu Gly Ala 260 265 270 Gly Met Leu Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His 275 280 285 Pro Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala 290 295 300 Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala Gln Gln Arg Val Ile 305 310 315 320 Arg Glu Ala Leu Ala Asp Ala Gly Leu Thr Pro Ala Asp Val Asp Ala 325 330 335 Val Glu Ala His Gly Thr Gly Thr Pro Leu Gly Asp Pro Ile Glu Ala 340 345 350 Gly Ala Leu Met Ala Thr Tyr Gly His Glu Arg Thr Gly Asp Pro Leu 355 360 365 Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Thr Gln Ala Ala Ala 370 375 380 Gly Val Ala Gly Val Ile Lys Met Val Leu Ala Leu Arg His Gly Glu 385 390 395 400 Leu Pro Arg Thr Leu His Ala Ser Thr Ala Ser Ser Arg Ile Glu Trp 405 410 415 Asp Ala Gly Ala Val Glu Leu Leu Asp Glu Ala Arg Pro Trp Pro Arg 420 425 430 Arg Ala Glu Gly Pro Arg Arg Ala Gly Ile Ser Ser Phe Gly Ile Ser 435 440 445 Gly Thr Asn Ala His Leu Val Ile Glu Glu Glu Pro Pro Ala Arg Pro 450 455 460 Glu Pro Glu Glu Ala Ala Gln Pro Pro Ala Pro Ala Thr Thr Val Leu 465 470 475 480 Pro Leu Ser Ala Ala Gly Ala Arg Ser Leu Arg Glu Gln Ala Arg Arg 485 490 495 Leu Ala Ala His Leu Ala Gly His Glu Glu Ile Thr Ala Ala Asp Ala 500 505 510 Ala Arg Ser Ala Ala Thr Thr Arg Ala Ala Leu Ser His Arg Ala Ser 515 520 525 Val Leu Ala Asp Asp Arg Arg Ala Leu Ile Asp Arg Leu Thr Ala Leu 530 535 540 Ala Glu Asp Arg Lys Asp Pro Gly Val Thr Val Gly Glu Ala Gly Ser 545 550 555 560 Gly Arg Pro Pro Val Phe Val Phe Pro Gly Gln Gly Ser Gln Trp Thr 565 570 575 Gly Met Gly Ala Glu Leu Leu Asp Arg Ala Pro Val Phe Arg Ala Lys 580 585 590 Ala Glu Glu Cys Ala Arg Ala Leu Ala Ala His Leu Asp Trp Ser Val 595 600 605 Leu Asp Val Leu Arg Asp Ala Pro Gly Ala Pro Pro Ile Asp Arg Ala 610 615 620 Asp Val Val Gln Pro Thr Leu Phe Thr Met Met Val Ser Leu Ala Ala 625 630 635 640 Leu Trp Glu Ser His Gly Val Arg Pro Ala Ala Val Val Gly His Ser 645 650 655 Gln Gly Glu Ile Ala Ala Ala His Ala Ala Gly Ala Leu Ser Leu Asp 660 665 670 Asp Ala Ala Arg Val Ile Ala Glu Arg Ser Arg Leu Trp Lys Arg Leu 675 680 685 Ala Gly Asn Gly Gly Met Leu Ser Val Met Ala Pro Ala Asp Arg Val 690 695 700 Arg Glu Leu Met Glu Pro Trp Ala Glu Arg Met Ser Val Ala Ala Val 705 710 715 720 Asn Gly Pro Ala Ser Val Thr Val Ala Gly Asp Ala Arg Ala Leu Glu 725 730 735 Glu Phe Gly Gly Arg Leu Ser Ala Ala Gly Val Leu Arg Trp Pro Leu 740 745 750 Ala Gly Val Asp Phe Ala Gly His Ser Pro Gln Val Glu Gln Phe Arg 755 760 765 Ala Glu Leu Leu Asp Thr Leu Gly Thr Val Arg Pro Thr Ala Ala Arg 770 775 780 Leu Pro Phe Phe Ser Thr Val Thr Ala Ala Ala His Glu Pro Glu Gly 785 790 795 800 Leu Asp Ala Ala Tyr Trp Tyr Arg Asn Met Arg Glu Pro Val Glu Phe 805 810 815 Ala Ser Thr Leu Arg Thr Leu Leu Arg Glu Gly His Arg Thr Phe Val 820 825 830 Glu Met Gly Pro His Pro Leu Leu Gly Ala Ala Ile Asp Glu Val Ala 835 840 845 Glu Ala Glu Gly Val His Ala Thr Ala Leu Ala Thr Leu His Arg Gly 850 855 860 Ser Gly Gly Leu Asp Arg Phe Arg Ser Ser Val Gly Ala Ala Phe Ala 865 870 875 880 His Gly Val Arg Val Asp Trp Asp Ala Leu Phe Glu Gly Ser Gly Ala 885 890 895 Arg Arg Val Pro Leu Pro Thr Tyr Ala Phe Ser Arg Asp Arg Tyr Trp 900 905 910 Leu Pro Thr Ala Ile Gly Arg Arg Ala Val Glu Ala Ala Pro Val Asp 915 920 925 Ala Ser Ala Pro Gly Arg Tyr Arg Val Thr Trp Thr Pro Val Ala Ser 930 935 940 Asp Asp Ser Gly Arg Pro Ser Gly Arg Trp Leu Leu Val Gln Thr Pro 945 950 955 960 Gly Thr Ala Pro Asp Glu Ala Asp Thr Ala Ala Ser Ala Leu Gly Ala 965 970 975 Ala Gly Val Val Val Glu Arg Cys Leu Leu Asp Pro Thr Glu Ala Ala 980 985 990 Arg Val Thr Leu Thr Glu Arg Leu Ala Glu Leu Asp Ala Gln Pro Glu 995 1000 1005 Gly Leu Ala Gly Val Leu Val Leu Pro Gly Arg Pro Gln Ser Thr Ala 1010 1015 1020 Pro Ala Asp Ala Ser Pro Leu Asp Pro Gly Thr Ala Ala Val Leu Leu 1025 1030 1035 1040 Val Val Gln Ala Val Pro Asp Ala Ala Pro Lys Ala Arg Ile Trp Val 1045 1050 1055 Val Thr Arg Gly Ala Val Ala Val Gly Ser Gly Glu Val Pro Cys Ala 1060 1065 1070 Val Gly Ala Arg Val Trp Gly Leu Gly Arg Val Ala Ala Leu Glu Val 1075 1080 1085 Pro Val Gln Trp Gly Gly Leu Val Asp Val Ala Val Gly Ala Gly Val 1090 1095 1100 Arg Glu Trp Arg Arg Val Val Gly Val Val Ala Gly Gly Gly Glu Asp 1105 1110 1115 1120 Gln Val Ala Val Arg Gly Gly Gly Val Phe Gly Arg Arg Leu Val Gly 1125 1130 1135 Val Gly Val Arg Gly Gly Ser Gly Val Trp Arg Ala Arg Gly Cys Val 1140 1145 1150 Val Val Thr Gly Gly Leu Gly Gly Val Gly Gly His Val Ala Arg Trp 1155 1160 1165 Leu Ala Arg Ser Gly Ala Glu His Val Val Leu Ala Gly Arg Arg Gly 1170 1175 1180 Gly Gly Val Val Gly Ala Val Glu Leu Glu Arg Glu Leu Val Gly Leu 1185 1190 1195 1200 Gly Ala Lys Val Thr Phe Val Ser Cys Asp Val Gly Asp Arg Ala Ser 1205 1210 1215 Met Val Gly Leu Leu Gly Val Val Glu Gly Leu Gly Val Pro Leu Arg 1220 1225 1230 Gly Val Phe His Ala Ala Gly Val Ala Gln Val Ser Gly Leu Gly Glu 1235 1240 1245 Val Ser Leu Ala Glu Ala Gly Gly Val Leu Gly Gly Lys Ala Val Gly 1250 1255 1260 Ala Glu Leu Leu Asp Glu Leu Thr Ala Gly Val Glu Leu Asp Ala Phe 1265 1270 1275 1280 Val Leu Phe Ser Ser Gly Ala Gly Val Trp Gly Ser Gly Gly Gln Ser 1285 1290 1295 Val Tyr Ala Ala Ala Asn Ala His Leu Asp Ala Leu Ala Glu Arg Arg 1300 1305 1310 Arg Ala Gln Gly Arg Pro Ala Thr Ser Val Ala Trp Gly Leu Trp Gly 1315 1320 1325 Gly Glu Gly Met Gly Ala Asp Glu Gly Val Thr Glu Phe Tyr Ala Glu 1330 1335 1340 Arg Gly Leu Ala Pro Met Arg Pro Glu Ser Gly Ile Glu Ala Leu His 1345 1350 1355 1360 Thr Ala Leu Asn Glu Gly Asp Thr Cys Val Thr Val Ala Asp Ile Asp 1365 1370 1375 Trp Glu His Phe Val Thr Gly Phe Thr Ala Tyr Arg Pro Ser Pro Leu 1380 1385 1390 Ile Ser Asp Ile Pro Gln Val Arg Ala Leu Arg Thr Pro Glu Pro Thr 1395 1400 1405 Val Asp Ala Ser Asp Gly Leu Arg Arg Arg Val Asp Ala Ala Leu Thr 1410 1415 1420 Pro Arg Glu Arg Thr Lys Val Leu Val Asp Leu Val Arg Thr Val Ala 1425 1430 1435 1440 Ala Glu Val Leu Gly His Asp Gly Ile Gly Gly Ile Gly His Asp Val 1445 1450 1455 Ala Phe Arg Asp Leu Gly Phe Asp Ser Leu Ala Ala Val Arg Met Arg 1460 1465 1470 Gly Arg Leu Ala Glu Ala Thr Gly Leu Val Leu Pro Ala Thr Val Ile 1475 1480 1485 Phe Asp His Pro Thr Val Asp Arg Leu Gly Gly Ala Leu Leu Glu Arg 1490 1495 1500 Leu Ser Ala Asp Glu Pro Ala Pro Gly Gly Ala Pro Glu Pro Ala Gly 1505 1510 1515 1520 Gly Arg Pro Ala Thr Pro Pro Pro Ala Pro Glu Pro Ala Val His Asp 1525 1530 1535 Ala Asp Ile Asp Glu Leu Asp Ala Asp Ala Leu Ile Arg Leu Ala Thr 1540 1545 1550 Gly Thr Ala Gly Pro Ala Asp Gly Thr Pro Ala Asp Gly Gly Pro Asp 1555 1560 1565 Ala Ala Ala Thr Ala Pro Asp Gly Ala Pro Glu Gln 1570 1575 1580

【００４６】配列番号：１２配列の長さ：１８９１アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Ser Pro Ser Met Asp Glu Val Leu Gly Ala Leu Arg Thr Ser Val 1 5 10 15 Lys Glu Thr Glu Arg Leu Arg Arg His Asn Arg Glu Leu Leu Ala Gly 20 25 30 Ala His Glu Pro Val Ala Ile Val Gly Met Ala Cys Arg Tyr Pro Gly 35 40 45 Gly Val Ser Thr Pro Asp Asp Leu Trp Glu Leu Ala Ala Asp Gly Val 50 55 60 Asp Ala Ile Thr Pro Phe Pro Ala Asp Arg Gly Trp Asp Glu Asp Ala 65 70 75 80 Val Tyr Ser Pro Asp Pro Asp Thr Pro Gly Thr Thr Tyr Cys Arg Glu 85 90 95 Gly Gly Phe Leu Thr Gly Ala Gly Asp Phe Asp Ala Ala Phe Phe Gly 100 105 110 Ile Ser Pro Asn Glu Ala Leu Val Met Asp Pro Gln Gln Arg Leu Leu 115 120 125 Leu Glu Thr Ser Trp Glu Thr Leu Glu Arg Ala Gly Ile Val Pro Ala 130 135 140 Ser Leu Arg Gly Ser Arg Thr Gly Val Phe Val Gly Ala Ala His Thr 145 150 155 160 Gly Tyr Val Thr Asp Thr Ala Arg Ala Pro Glu Gly Thr Glu Gly Tyr 165 170 175 Leu Leu Thr Gly Asn Ala Asp Ala Val Met Ser Gly Arg Ile Ala Tyr 180 185 190 Ser Leu Gly Leu Glu Gly Pro Ala Leu Thr Ile Gly Thr Ala Cys Ser 195 200 205 Ser Ser Leu Val Ala Leu His Leu Ala Val Gln Ser Leu Arg Arg Gly 210 215 220 Glu Cys Asp Leu Ala Leu Ala Gly Gly Val Ala Val Met Pro Asp Pro 225 230 235 240 Thr Val Phe Val Glu Phe Ser Arg Gln Arg Gly Leu Ala Val Asp Gly 245 250 255 Arg Cys Lys Ala Phe Ala Glu Gly Ala Asp Gly Thr Ala Trp Ala Glu 260 265 270 Gly Val Gly Val Leu Leu Val Glu Arg Leu Ser Asp Ala Arg Arg Asn 275 280 285 Gly His Arg Val Leu Ala Val Val Arg Gly Ser Ala Val Asn Gln Asp 290 295 300 Gly Ala Ser Asn Gly Leu Thr Ala Pro Ser Gly Pro Ala Gln Gln Arg 305 310 315 320 Val Ile Arg Glu Ala Leu Ala Asp Ala Gly Leu Thr Pro Ala Asp Val 325 330 335 Asp Val Val Glu Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile 340 345 350 Glu Ala Gly Ala Leu Leu Ala Thr Tyr Gly Arg Glu Arg Val Gly Asp 355 360 365 Pro Leu Trp Leu Gly Ser Leu Lys Ser Asn Ile Gly His Ala Gln Ala 370 375 380 Ala Ala Gly Val Gly Gly Val Ile Lys Val Val Gln Ala Met Arg His 385 390 395 400 Gly Ser Leu Pro Arg Thr Leu His Val Asp Ala Pro Ser Ser Lys Val 405 410 415 Glu Trp Ala Ser Gly Ala Val Glu Leu Leu Thr Glu Gly Arg Ser Trp 420 425 430 Pro Arg Arg Val Glu Arg Val Arg Arg Ala Ala Val Ser Ala Phe Gly 435 440 445 Val Ser Gly Thr Asn Ala His Val Val Leu Glu Glu Ala Pro Val Glu 450 455 460 Ala Gly Ser Glu His Gly Asp Gly Pro Gly Pro Asp Arg Pro Asp Ala 465 470 475 480 Val Thr Gly Pro Leu Pro Trp Val Leu Ser Ala Arg Ser Arg Glu Ala 485 490 495 Leu Arg Gly Gln Ala Gly Arg Leu Ala Ala Leu Ala Arg Gln Gly Arg 500 505 510 Thr Glu Gly Thr Gly Gly Gly Ser Gly Leu Val Val Pro Ala Ala Asp 515 520 525 Ile Gly Tyr Ser Leu Ala Thr Thr Arg Glu Thr Leu Glu His Arg Ala 530 535 540 Val Ala Leu Val Gln Glu Asn Arg Thr Ala Gly Glu Asp Leu Ala Ala 545 550 555 560 Leu Ala Ala Gly Arg Thr Pro Glu Ser Val Val Thr Gly Val Ala Arg 565 570 575 Arg Gly Arg Gly Ile Ala Phe Leu Cys Ser Gly Gln Gly Ala Gln Arg 580 585 590 Leu Gly Ala Gly Arg Glu Leu Arg Gly Arg Phe Pro Val Phe Ala Asp 595 600 605 Ala Leu Asp Glu Ile Ala Ala Glu Phe Asp Ala His Leu Glu Arg Pro 610 615 620 Leu Leu Ser Val Met Phe Ala Glu Pro Ala Thr Pro Asp Ala Ala Leu 625 630 635 640 Leu Asp Arg Thr Asp Tyr Thr Gln Pro Ala Leu Phe Ala Val Glu Thr 645 650 655 Ala Leu Phe Arg Leu Leu Glu Ser Trp Gly Leu Val Pro Asp Val Leu 660 665 670 Val Gly His Ser Ile Gly Gly Leu Val Ala Ala His Val Ala Gly Val 675 680 685 Phe Ser Ala Ala Asp Ala Ala Arg Leu Val Ser Ala Arg Gly Arg Leu 690 695 700 Met Arg Ala Leu Pro Glu Gly Gly Ala Met Ala Ala Val Gln Ala Thr 705 710 715 720 Glu Arg Glu Ala Ala Ala Leu Glu Pro Val Ala Ala Gly Gly Ala Val 725 730 735 Val Ala Ala Val Asn Gly Pro Gln Ala Leu Val Leu Ser Gly Asp Glu 740 745 750 Ala Ala Val Leu Ala Ala Ala Gly Glu Leu Ala Ala Arg Gly Arg Arg 755 760 765 Thr Lys Arg Leu Arg Val Ser His Ala Phe His Ser Pro Arg Met Asp 770 775 780 Ala Met Leu Ala Asp Phe Arg Ala Val Ala Asp Thr Val Asp Tyr His 785 790 795 800 Ala Pro Arg Leu Pro Val Val Ser Glu Val Thr Gly Asp Leu Ala Asp 805 810 815 Ala Ala Gln Leu Thr Asp Pro Gly Tyr Trp Thr Arg Gln Val Arg Gln 820 825 830 Pro Val Arg Phe Ala Asp Ala Val Arg Thr Ala Ser Ala Arg Asp Ala 835 840 845 Ala Thr Phe Ile Glu Leu Gly Pro Asp Ala Val Leu Cys Gly Met Ala 850 855 860 Glu Glu Ser Leu Ala Ala Glu Ala Asp Val Val Phe Ala Pro Ala Leu 865 870 875 880 Arg Arg Gly Arg Pro Glu Gly Asp Thr Val Leu Arg Ala Ala Ala Ser 885 890 895 Ala Tyr Val Arg Gly Ala Gly Leu Asp Trp Ala Ala Leu Tyr Gly Gly 900 905 910 Thr Gly Ala Arg Arg Thr Asp Leu Pro Thr Tyr Ala Phe Gln His Ser 915 920 925 Arg Tyr Trp Leu Ala Pro Ala Ser Ala Ala Val Ala Pro Ala Thr Ala 930 935 940 Ala Pro Ser Val Arg Ser Val Pro Glu Ala Glu Gln Asp Gly Ala Leu 945 950 955 960 Trp Ala Ala Val His Ala Gly Asp Val Ala Ser Ala Ala Ala Arg Leu 965 970 975 Gly Ala Asp Asp Ala Gly Ile Glu His Glu Leu Arg Ala Val Leu Pro 980 985 990 His Leu Ala Ala Trp His Asp Arg Asp Arg Ala Thr Ala Arg Thr Ala 995 1000 1005 Gly Leu His Tyr Arg Val Thr Trp Gln Ala Ile Glu Ala Asp Ala Val 1010 1015 1020 Arg Phe Ser Pro Ser Asp Arg Trp Leu Met Val Glu His Gly Gln His 1025 1030 1035 1040 Thr Glu Cys Ala Asp Ala Ala Glu Arg Ala Leu Arg Ala Ala Gly Ala 1045 1050 1055 Glu Val Thr Arg Leu Val Trp Pro Leu Glu Gln His Thr Gly Ser Pro 1060 1065 1070 Arg Thr Glu Thr Pro Asp Arg Gly Thr Leu Ala Ala Arg Leu Ala Glu 1075 1080 1085 Leu Ala Arg Ser Pro Glu Gly Leu Ala Gly Val Leu Leu Leu Pro Asp 1090 1095 1100 Ser Gly Gly Ala Ala Val Ala Gly His Pro Gly Leu Asp Gln Gly Thr 1105 1110 1115 1120 Ala Ala Val Leu Leu Thr Ile Gln Ala Leu Thr Asp Ala Ala Val Arg 1125 1130 1135 Ala Pro Leu Trp Val Val Thr Arg Gly Ala Val Ala Val Gly Ser Gly 1140 1145 1150 Glu Val Pro Cys Ala Val Gly Ala Arg Val Trp Gly Leu Gly Arg Val 1155 1160 1165 Ala Ala Leu Glu Val Pro Val Gln Trp Gly Gly Leu Val Asp Val Ala 1170 1175 1180 Val Gly Ala Gly Val Arg Glu Trp Arg Arg Val Val Gly Val Val Ala 1185 1190 1195 1200 Gly Gly Gly Glu Asp Gln Val Ala Val Arg Gly Gly Gly Val Phe Gly 1205 1210 1215 Arg Arg Leu Val Gly Val Gly Val Arg Gly Gly Ser Gly Val Trp Arg 1220 1225 1230 Ala Arg Gly Cys Val Val Val Thr Gly Gly Leu Gly Gly Val Gly Gly 1235 1240 1245 His Val Ala Arg Trp Leu Ala Arg Ser Gly Ala Glu His Val Val Leu 1250 1255 1260 Ala Gly Arg Arg Gly Gly Gly Val Val Gly Ala Val Glu Leu Glu Arg 1265 1270 1275 1280 Glu Leu Val Gly Leu Gly Ala Lys Val Thr Phe Val Ser Cys Asp Val 1285 1290 1295 Gly Asp Arg Ala Ser Val Val Gly Leu Leu Gly Val Val Glu Gly Leu 1300 1305 1310 Gly Val Pro Leu Arg Gly Val Phe His Ala Ala Gly Val Ala Gln Val 1315 1320 1325 Ser Gly Leu Gly Glu Val Ser Leu Ala Glu Ala Gly Gly Val Leu Gly 1330 1335 1340 Gly Lys Ala Val Gly Ala Glu Leu Leu Asp Glu Leu Thr Ala Gly Val 1345 1350 1355 1360 Glu Leu Asp Ala Phe Val Leu Phe Ser Ser Gly Ala Gly Val Trp Gly 1365 1370 1375 Ser Gly Gly Gln Ser Val Tyr Ala Ala Ala Asn Ala His Leu Asp Ala 1380 1385 1390 Leu Ala Glu Arg Arg Arg Ala Gln Gly Arg Pro Ala Thr Ser Val Ala 1395 1400 1405 Trp Gly Pro Trp Asp Gly Asp Gly Met Gly Glu Met Ala Pro Glu Gly 1410 1415 1420 Tyr Phe Ala Arg His Gly Val Ala Pro Leu His Pro Glu Thr Ala Leu 1425 1430 1435 1440 Thr Ala Leu His Gln Ala Ile Asp Gly Gly Glu Ala Thr Val Thr Val 1445 1450 1455 Ala Asp Ile Asp Trp Glu Arg Phe Ala Pro Gly Phe Thr Ala Phe Arg 1460 1465 1470 Pro Ser Pro Leu Ile Ala Gly Ile Pro Ala Ala Arg Thr Ala Pro Ala 1475 1480 1485 Ala Gly Arg Pro Ala Glu Asp Thr Pro Thr Ala Pro Gly Leu Leu Arg 1490 1495 1500 Ala Arg Pro Glu Asp Arg Pro Arg Leu Ala Leu Asp Leu Val Leu Arg 1505 1510 1515 1520 His Val Ala Ala Val Leu Gly His Ser Glu Asp Ala Arg Val Asp Ala 1525 1530 1535 Arg Ala Pro Phe Arg Asp Leu Gly Phe Asp Ser Leu Ala Ala Val Arg 1540 1545 1550 Leu Arg Arg Arg Leu Ala Glu Asp Thr Gly Leu Asp Leu Pro Gly Thr 1555 1560 1565 Leu Val Phe Asp His Glu Asp Pro Thr Ala Leu Ala His His Leu Ala 1570 1575 1580 Gly Leu Ala Asp Ala Gly Thr Pro Gly Pro Gln Glu Gly Thr Ala Arg 1585 1590 1595 1600 Ala Glu Ser Gly Leu Phe Ala Ser Phe Arg Ala Ala Val Glu Gln Arg 1605 1610 1615 Arg Ser Ser Glu Val Val Glu Leu Met Ala Asp Leu Ala Ala Phe Arg 1620 1625 1630 Pro Ala Tyr Ser Arg Gln His Pro Gly Ser Gly Arg Pro Ala Pro Val 1635 1640 1645 Pro Leu Ala Thr Gly Pro Ala Thr Arg Pro Thr Leu Tyr Cys Cys Ala 1650 1655 1660 Gly Thr Ala Val Gly Ser Gly Pro Ala Glu Tyr Val Pro Phe Ala Glu 1665 1670 1675 1680 Gly Leu Arg Gly Val Arg Glu Thr Val Ala Leu Pro Leu Ser Gly Phe 1685 1690 1695 Gly Asp Pro Ala Glu Pro Met Pro Ala Ser Leu Asp Ala Leu Ile Glu 1700 1705 1710 Val Gln Ala Asp Val Leu Leu Glu His Thr Ala Gly Lys Pro Phe Ala 1715 1720 1725 Leu Ala Gly His Ser Ala Gly Ala Asn Ile Ala His Ala Leu Ala Ala 1730 1735 1740 Arg Leu Glu Glu Arg Gly Ser Gly Pro Ala Ala Val Val Leu Met Asp 1745 1750 1755 1760 Val Tyr Arg Pro Glu Asp Pro Gly Ala Met Gly Glu Trp Arg Asp Asp 1765 1770 1775 Leu Leu Ser Trp Ala Leu Glu Arg Ser Thr Val Pro Leu Glu Asp His 1780 1785 1790 Arg Leu Thr Ala Met Ala Gly Tyr Gln Arg Leu Val Leu Gly Thr Arg 1795 1800 1805 Leu Thr Ala Leu Glu Ala Pro Val Leu Leu Ala Arg Ala Ser Glu Pro 1810 1815 1820 Leu Cys Ala Trp Pro Pro Ala Gly Gly Ala Arg Gly Asp Trp Arg Ser 1825 1830 1835 1840 Gln Val Pro Phe Ala Arg Thr Val Ala Asp Val Pro Gly Asn His Phe 1845 1850 1855 Thr Met Leu Thr Glu His Ala Arg His Thr Ala Ser Leu Val His Glu 1860 1865 1870 Trp Leu Asp Ser Leu Pro His Gln Pro Gly Pro Ala Pro Leu Thr Gly 1875 1880 1885 Gly Lys His 1890

【００４７】配列番号：１３配列の長さ：１３９８７塩基対配列の型：核酸鎖の数：一本鎖トポロジー：直鎖状配列の種類：ＤＮＡ（genomic）配列の特徴特徴を表す記号：ＣＤＳ存在位置：３５０．．１３９８７配列 GACCGCTCGG GGAGACCTGA CATATTCGTC GCGAAGTGGT TGTCCGCGCC GCGAGGTACT 60 GAAATCTTCT CCGCTCGCCC AGGACTCCGC GTGCAGGTCA CCGGAGTGCG CGACCGGCCG 120 GGACGTCGGA GCGCCGACCC TGCGGACCTG GTGCGATGCC GTGTGGTCCC GCATGATCCC 180 GCGCCGTCTC CGGTGACGAG AATCGGTGGA CAATCTCCGA ACTTGACACA ATTGATTGTC 240 GTTCACCGGC CGTTCCTGTC GCCCGGCAGT TCGCCCGCTG TACGCTCGGG AAGATCAAGA 300 AAAGGCAGAA AAGCCACGGC GTGGTACGGC GAACATATGA GGGATGCAG GTG TCT 355 Met Ser 1 GGA GAA CTC GCG ATT TCC CGC AGT GAC GAC CGG TCC GAC GCC GTT GCC 403 Gly Glu Leu Ala Ile Ser Arg Ser Asp Asp Arg Ser Asp Ala Val Ala 5 10 15 GTG GTC GGA ATG GCG TGC CGG TTT CCC GGC GCC CCG GGA ATT GCC GAA 451 Val Val Gly Met Ala Cys Arg Phe Pro Gly Ala Pro Gly Ile Ala Glu 20 25 30 TTC TGG GAA CTG CTG CGC AGC GGA CGC GGT ATG CCC ACC CGT CAG GAC 499 Phe Trp Glu Leu Leu Arg Ser Gly Arg Gly Met Pro Thr Arg Gln Asp 35 40 45 50 GAC GGC ACC TGG CGG GCC GCC CTG GAG GAC CAC GCC GGC TTC GAC GCC 547 Asp Gly Thr Trp Arg Ala Ala Leu Glu Asp His Ala Gly Phe Asp Ala 55 60 65 GGG TTC TTC GGC ATG AAC GCC CGG CAG GCC GCC GCC ACC GAC CCG CAG 595 Gly Phe Phe Gly Met Asn Ala Arg Gln Ala Ala Ala Thr Asp Pro Gln 70 75 80 CAC CGA CTG ATG CTG GAA CTC GGA TGG GAG GCA CTG GAG GAC GCG GGC 643 His Arg Leu Met Leu Glu Leu Gly Trp Glu Ala Leu Glu Asp Ala Gly 85 90 95 ATC GTC CCC GGC GAT CTC ACC GGC ACC GAC ACC GGA GTC TTC GCC GGC 691 Ile Val Pro Gly Asp Leu Thr Gly Thr Asp Thr Gly Val Phe Ala Gly 100 105 110 GTG GCG TCC GAC GAC TAT GCC GTT CTC ACC CGC CGT TCC GCC GTC TCC 739 Val Ala Ser Asp Asp Tyr Ala Val Leu Thr Arg Arg Ser Ala Val Ser 115 120 125 130 GCC GGG GGA TAC ACC GCC ACG GGG CTG CAC CGC GCC CTG GCC GCC AAC 787 Ala Gly Gly Tyr Thr Ala Thr Gly Leu His Arg Ala Leu Ala Ala Asn 135 140 145 CGC CTC TCC CAC TTC CTG GGC CTG CGC GGC CCC AGC CTG GTC GTC GAC 835 Arg Leu Ser His Phe Leu Gly Leu Arg Gly Pro Ser Leu Val Val Asp 150 155 160 TCG GCC CAG TCC GCC TCA CTG GTG GCC GTC CAG CTC GCC TGC GAG AGT 883 Ser Ala Gln Ser Ala Ser Leu Val Ala Val Gln Leu Ala Cys Glu Ser 165 170 175 CTG CGC CGG GGT GAG ACG TCG CTC GCC GTC GCG GGC GGT GTC AAC CTC 931 Leu Arg Arg Gly Glu Thr Ser Leu Ala Val Ala Gly Gly Val Asn Leu 180 185 190 ATC CTC ACC GAG GAG AGC ACC ACC GTC ATG GAG CGT ATG GGA GCG CTC 979 Ile Leu Thr Glu Glu Ser Thr Thr Val Met Glu Arg Met Gly Ala Leu 195 200 205 210 TCA CCC GAC GGC CGC TGC CAC ACC TTC GAC GCC CGC GCC AAC GGC TAC 1027 Ser Pro Asp Gly Arg Cys His Thr Phe Asp Ala Arg Ala Asn Gly Tyr 215 220 225 GTA CGC GGC GAG GGC GGC GGA GCC GTC GTG CTC AAG CCA CTG GAC GCC 1075 Val Arg Gly Glu Gly Gly Gly Ala Val Val Leu Lys Pro Leu Asp Ala 230 235 240 GCA CTC GCC GAC GGC GAC CGC GTG TAC TGC GTC ATC AAG GGA GGT GCC 1123 Ala Leu Ala Asp Gly Asp Arg Val Tyr Cys Val Ile Lys Gly Gly Ala 245 250 255 GTC AAC AAC GAC GGC GGC GGC GCG AGC CTC ACC ACT CCC GAC CGG GAG 1171 Val Asn Asn Asp Gly Gly Gly Ala Ser Leu Thr Thr Pro Asp Arg Glu 260 265 270 GCG CAG GAA GCT GTG CTG CGC CAG GCC TAC CGG CGG GCG GGC GTC AGC 1219 Ala Gln Glu Ala Val Leu Arg Gln Ala Tyr Arg Arg Ala Gly Val Ser 275 280 285 290 ACC GGC GCC GTC CGC TAC GTC GAG CTG CAC GGG ACC GGC ACC CGG GCC 1267 Thr Gly Ala Val Arg Tyr Val Glu Leu His Gly Thr Gly Thr Arg Ala 295 300 305 GGC GAC CCC GTC GAG GCG GCC GCA CTG GGC GCC GTG CTC GGG GCG GGG 1315 Gly Asp Pro Val Glu Ala Ala Ala Leu Gly Ala Val Leu Gly Ala Gly 310 315 320 GCG GAC AGC GGC CGC AGC ACG CCG CTC GCC GTC GGC TCG GTG AAG ACC 1363 Ala Asp Ser Gly Arg Ser Thr Pro Leu Ala Val Gly Ser Val Lys Thr 325 330 335 AAC GTC GGC CAT CTG GAG GGC GCG GCG GGC ATC GTC GGA CTG ATC AAG 1411 Asn Val Gly His Leu Glu Gly Ala Ala Gly Ile Val Gly Leu Ile Lys 340 345 350 GCC ACG CTG TGC GTA CGG AAG GGC GAA CTC GTC CCC AGC CTC AAC TTC 1459 Ala Thr Leu Cys Val Arg Lys Gly Glu Leu Val Pro Ser Leu Asn Phe 355 360 365 370 AGC ACG CCG AAC CCT GAC ATC CCC CTC GAC GAC CTG CGG CTG CGC GTC 1507 Ser Thr Pro Asn Pro Asp Ile Pro Leu Asp Asp Leu Arg Leu Arg Val 375 380 385 CAG ACC GAA CGG CAG GAG TGG AAC GAG GAG GAC GAC CGG CCG CGC GTG 1555 Gln Thr Glu Arg Gln Glu Trp Asn Glu Glu Asp Asp Arg Pro Arg Val 390 395 400 GCC GGC GTC TCC TCC TTC GGT ATG GGC GGA ACC AAT GTC CAC CTC GTG 1603 Ala Gly Val Ser Ser Phe Gly Met Gly Gly Thr Asn Val His Leu Val 405 410 415 ATC GCG GAG GCT CCG GCC GCG GCG GGG TCC TCC GGG GCG GGG GGT TCG 1651 Ile Ala Glu Ala Pro Ala Ala Ala Gly Ser Ser Gly Ala Gly Gly Ser 420 425 430 GGC GCT GGT TCC GGT GCC GGT ATC AGC GCT GTT TCT GGT GTG GTG CCG 1699 Gly Ala Gly Ser Gly Ala Gly Ile Ser Ala Val Ser Gly Val Val Pro 435 440 445 450 GTG GTG GTT TCG GGG CGT TCG CGG GTG GTG GTG CGG GAG GCT GCG GGC 1747 Val Val Val Ser Gly Arg Ser Arg Val Val Val Arg Glu Ala Ala Gly 455 460 465 CGG TTG GCG GAG GTG GTG GAG GCC GGT GGT GTG GGG CTG GCG GAT GTG 1795 Arg Leu Ala Glu Val Val Glu Ala Gly Gly Val Gly Leu Ala Asp Val 470 475 480 GCG GTG ACG ATG GCG GAC CGG TCG CGG TTT GGG TAT CGG GCG GTT GTG 1843 Ala Val Thr Met Ala Asp Arg Ser Arg Phe Gly Tyr Arg Ala Val Val 485 490 495 CTG GCT CGG GGT GAG GCT GAG CTT GCC GGG CGT TTG CGG GCG TTG GCG 1891 Leu Ala Arg Gly Glu Ala Glu Leu Ala Gly Arg Leu Arg Ala Leu Ala 500 505 510 GGG GGT GAT CCG GAC GCG GGT GTG GTC ACC GGT GCG GTT CTC GAC GGT 1939 Gly Gly Asp Pro Asp Ala Gly Val Val Thr Gly Ala Val Leu Asp Gly 515 520 525 530 GGT GTG GTT GTC GGT GCT GCC CCC GGC GGT GCC GGT GCT GCC GGT GGT 1987 Gly Val Val Val Gly Ala Ala Pro Gly Gly Ala Gly Ala Ala Gly Gly 535 540 545 GCC GGT GCT GCC GGT GGT GCC GGT GGT GGG GGC GTG GTG TTG GTT TTC 2035 Ala Gly Ala Ala Gly Gly Ala Gly Gly Gly Gly Val Val Leu Val Phe 550 555 560 CCT GGT CAG GGG ACG CAG TGG GTG GGG ATG GGT GCG GGG CTG CTG GGG 2083 Pro Gly Gln Gly Thr Gln Trp Val Gly Met Gly Ala Gly Leu Leu Gly 565 570 575 TCT TCG GAG GTG TTT GCG GCG TCG ATG CGG GAG TGT GCG CGG GCG CTG 2131 Ser Ser Glu Val Phe Ala Ala Ser Met Arg Glu Cys Ala Arg Ala Leu 580 585 590 AGT GTT CAT GTG GGG TGG GAT TTG CTG GAG GTG GTG TCG GGC GGG GCC 2179 Ser Val His Val Gly Trp Asp Leu Leu Glu Val Val Ser Gly Gly Ala 595 600 605 610 GGG TTG GAG CGG GTG GAT GTG GTG CAG CCG GTG ACG TGG GCG GTG ATG 2227 Gly Leu Glu Arg Val Asp Val Val Gln Pro Val Thr Trp Ala Val Met 615 620 625 GTG TCG CTG GCC CGG TAC TGG CAG GCG ATG GGT GTG GAC GTG GCT GCG 2275 Val Ser Leu Ala Arg Tyr Trp Gln Ala Met Gly Val Asp Val Ala Ala 630 635 640 GTG GTG GGT CAT TCC CAG GGG GAG ATC GCC GCT GCC ACG GTG GCG GGG 2323 Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Thr Val Ala Gly 645 650 655 GCG TTG TCG CTG GAG GAT GCG GCG GCT GTG GTC GCT CTG CGG GCG GGG 2371 Ala Leu Ser Leu Glu Asp Ala Ala Ala Val Val Ala Leu Arg Ala Gly 660 665 670 TTG ATT GGC CGG TAT CTG GCG GGT CGT GGT GCG ATG GCG GCT GTT CCG 2419 Leu Ile Gly Arg Tyr Leu Ala Gly Arg Gly Ala Met Ala Ala Val Pro 675 680 685 690 CTG CCT GCC GGC GAG GTC GAG GCC GGG CTG GCG AAG TGG CCG GGT GTG 2467 Leu Pro Ala Gly Glu Val Glu Ala Gly Leu Ala Lys Trp Pro Gly Val 695 700 705 GAG GTC GCG GCG GTC AAC GGT CCG GCG TCT ACG GTG GTT TCC GGG GAT 2515 Glu Val Ala Ala Val Asn Gly Pro Ala Ser Thr Val Val Ser Gly Asp 710 715 720 CGG CGG GCG GTG GCC GGT TAT GTG GCC GTC TGT CAG GCG GAG GGT GTG 2563 Arg Arg Ala Val Ala Gly Tyr Val Ala Val Cys Gln Ala Glu Gly Val 725 730 735 CAG GCC CGG TTG ATA CCG GTG GAC TAC GCC TCT CAC TCC CGC CAT GTG 2611 Gln Ala Arg Leu Ile Pro Val Asp Tyr Ala Ser His Ser Arg His Val 740 745 750 GAG GAC CTG AAG GGC GAG TTG GAG CGG GTG CTG TCC GGT ATC CGC CCC 2659 Glu Asp Leu Lys Gly Glu Leu Glu Arg Val Leu Ser Gly Ile Arg Pro 755 760 765 770 CGC AGT CCG CGG GTG CCG GTG TGT TCC ACC GTC GCC GGA GAG CAG CCG 2707 Arg Ser Pro Arg Val Pro Val Cys Ser Thr Val Ala Gly Glu Gln Pro 775 780 785 GGC GAG CCG GTT TTC GAT GCG GGG TAT TGG TTC CGT AAT CTG CGG AAC 2755 Gly Glu Pro Val Phe Asp Ala Gly Tyr Trp Phe Arg Asn Leu Arg Asn 790 795 800 CGG GTT GAG TTC TCC GCG GTG GTC GGT GGT TTG TTG GAG GAG GGC CAC 2803 Arg Val Glu Phe Ser Ala Val Val Gly Gly Leu Leu Glu Glu Gly His 805 810 815 CGT CGG TTC ATC GAG GTC AGT GCC CAC CCG GTA CTC GTC CAT GCG ATC 2851 Arg Arg Phe Ile Glu Val Ser Ala His Pro Val Leu Val His Ala Ile 820 825 830 GAG CAG ACG GCC GAG GCC GCG GAC CGG AGT GTC CAT GCC ACC GGG ACC 2899 Glu Gln Thr Ala Glu Ala Ala Asp Arg Ser Val His Ala Thr Gly Thr 835 840 845 850 CTG CGC CGC CAG GAC GAC AGC CCG CAC CGC CTG CTG ACC TCC ACC GCC 2947 Leu Arg Arg Gln Asp Asp Ser Pro His Arg Leu Leu Thr Ser Thr Ala 855 860 865 GAG GCC TGG GCC CAC GGC GCC ACC CTC ACC TGG GAC CCC GCC CTG CCC 2995 Glu Ala Trp Ala His Gly Ala Thr Leu Thr Trp Asp Pro Ala Leu Pro 870 875 880 CCA GGC CAC CTC ACC ACC CTC CCC ACC TAC CCC TTC AAC CAC CAC CAC 3043 Pro Gly His Leu Thr Thr Leu Pro Thr Tyr Pro Phe Asn His His His 885 890 895 TAC TGG CTC GAC ACC ATT GAC GGG GGC GGA GGG GAC GAC GCG ACC CAG 3091 Tyr Trp Leu Asp Thr Ile Asp Gly Gly Gly Gly Asp Asp Ala Thr Gln 900 905 910 GAG AAG GAG AGC GGC CCT CTG ACG CGG GAA CTG CGT GGG CTG CCG TCC 3139 Glu Lys Glu Ser Gly Pro Leu Thr Arg Glu Leu Arg Gly Leu Pro Ser 915 920 925 930 TCT CAG AAG CAA CTG GGT TTC CTG CTC GAT CTG GTG TGC CGG CAC ACG 3187 Ser Gln Lys Gln Leu Gly Phe Leu Leu Asp Leu Val Cys Arg His Thr 935 940 945 GCC GTC GTA CTC GGC CTG GAC ACG GCC GCC GAG GTG GAC CCG GAC CTG 3235 Ala Val Val Leu Gly Leu Asp Thr Ala Ala Glu Val Asp Pro Asp Leu 950 955 960 TCC TTC AAG AAG CAG GGC ATC CAG TCC ATG ACC GGC GTC GAG CTG CGC 3283 Ser Phe Lys Lys Gln Gly Ile Gln Ser Met Thr Gly Val Glu Leu Arg 965 970 975 AAC AGG CTG CTG ACC GAG ACC GGC CTG GCA TTG CCC ACC ACC CTC GTC 3331 Asn Arg Leu Leu Thr Glu Thr Gly Leu Ala Leu Pro Thr Thr Leu Val 980 985 990 TAC GAC CGG CCC ACC CCT CGC GCC CTG GCG CAG TTC CTC CAC ACC GAG 3379 Tyr Asp Arg Pro Thr Pro Arg Ala Leu Ala Gln Phe Leu His Thr Glu 995 1000 1005 1010 TTG CTC GAC GGC TCC CCC TCG GGC TCC GTC CTC GCA CCG GCG CAG AAG 3427 Leu Leu Asp Gly Ser Pro Ser Gly Ser Val Leu Ala Pro Ala Gln Lys 1015 1020 1025 AGC TTC GAG GCC GGC GGG CCC GGA GTG CTC TCG TCG GCC GCG GTA GGG 3475 Ser Phe Glu Ala Gly Gly Pro Gly Val Leu Ser Ser Ala Ala Val Gly 1030 1035 1040 GTG TCG GAC GCC CGG GGC GGC AGC CGG GAC GAC GAC GAC CCG ATC GCC 3523 Val Ser Asp Ala Arg Gly Gly Ser Arg Asp Asp Asp Asp Pro Ile Ala 1045 1050 1055 ATC GTG GGT GTC GGC TGC CGG CTC CCC GGC GGC GTC GAC TCG CGC GCC 3571 Ile Val Gly Val Gly Cys Arg Leu Pro Gly Gly Val Asp Ser Arg Ala 1060 1065 1070 GCT CTC TGG GAG CTG CTG GAG TCC GGC GCC GAC GCC ATC TCG TCC TTC 3619 Ala Leu Trp Glu Leu Leu Glu Ser Gly Ala Asp Ala Ile Ser Ser Phe 1075 1080 1085 1090 CCC ACC GAC CGC GGC TGG GAC CTC GAC GGG CTG TAC GAC CCC GAG CCC 3667 Pro Thr Asp Arg Gly Trp Asp Leu Asp Gly Leu Tyr Asp Pro Glu Pro 1095 1100 1105 GGG ACG CCC GGC AAG ACC TAT GTG CGG GAG GGC GGG TTC CTG CAC TCG 3715 Gly Thr Pro Gly Lys Thr Tyr Val Arg Glu Gly Gly Phe Leu His Ser 1110 1115 1120 GCG GCC GAG TTC GAC GCG GAG TTC TTC GGG ATA TCG CCG CGC GAG GCC 3763 Ala Ala Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala 1125 1130 1135 ACG GCC ATG GAC CCG CAG CAG CGC TTG CTG CTG GAA GCG TCG TGG GAG 3811 Thr Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Ala Ser Trp Glu 1140 1145 1150 GCC CTC GAG GAC GCC GGA GTG CTC CCC GAG TCA CTG CGC GGC GGC GAC 3859 Ala Leu Glu Asp Ala Gly Val Leu Pro Glu Ser Leu Arg Gly Gly Asp 1155 1160 1165 1170 GCC GGA GTG TTC GTC GGC GCC ACC GCA CCG GAG TAC GGG CCG AGG CTT 3907 Ala Gly Val Phe Val Gly Ala Thr Ala Pro Glu Tyr Gly Pro Arg Leu 1175 1180 1185 CAC GAG GGA GCG GAC GGA TAC GAG GGG TAC CTG CTC ACC GGC ACC ACC 3955 His Glu Gly Ala Asp Gly Tyr Glu Gly Tyr Leu Leu Thr Gly Thr Thr 1190 1195 1200 GCG AGC GTG GCC TCC GGC CGG ATC GCC TAC ACC CTC GGC ACC GGC GGA 4003 Ala Ser Val Ala Ser Gly Arg Ile Ala Tyr Thr Leu Gly Thr Gly Gly 1205 1210 1215 CCG GCG CTC ACC GTC GAC ACC GCG TGC TCC TCG TCC CTG GTG GCG CTG 4051 Pro Ala Leu Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu 1220 1225 1230 CAC CTG GCC GTG CAG GCG CTG CGC CGG GGC GAG TGC GGG CTG GCT CTG 4099 His Leu Ala Val Gln Ala Leu Arg Arg Gly Glu Cys Gly Leu Ala Leu 1235 1240 1245 1250 GCG GGC GGC GCC ACG GTG ATG TCG GGG CCC GGC ATG TTC GTG GAG TTC 4147 Ala Gly Gly Ala Thr Val Met Ser Gly Pro Gly Met Phe Val Glu Phe 1255 1260 1265 TCG CGG CAG CGC GGG CTC GCC CCC GAC GGC CGC TGC ATG CCG TTC TCC 4195 Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Met Pro Phe Ser 1270 1275 1280 GCC GAT GCC GAC GGT ACG GCC TGG TCC GAG GGT GTC GCC GTA CTG GCA 4243 Ala Asp Ala Asp Gly Thr Ala Trp Ser Glu Gly Val Ala Val Leu Ala 1285 1290 1295 CTG GAG CGG CTC TCC GAC GCC CGG CGT GCG GGA CAC CGG GTG CTG GGC 4291 Leu Glu Arg Leu Ser Asp Ala Arg Arg Ala Gly His Arg Val Leu Gly 1300 1305 1310 GTG GTG CGG GGC AGT GCG GTC AAC CAG GAC GGT GCC AGC AAC GGC CTG 4339 Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu 1315 1320 1325 1330 ACC GCT CCC AAC CGC TCC GCG CAG GAG GGC GTC ATC CGA GCT GCC CTG 4387 Thr Ala Pro Asn Arg Ser Ala Gln Glu Gly Val Ile Arg Ala Ala Leu 1335 1340 1345 GCC GAC GCC GGC CTC GCG CCG GGT GAC GTG GAC GCG GTG GAG GCG CAC 4435 Ala Asp Ala Gly Leu Ala Pro Gly Asp Val Asp Ala Val Glu Ala His 1350 1355 1360 GGT ACG GGG ACG GCG CTG GGC GAT CCG ATC GAG GCG AGC GCG CTG CTG 4483 Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Ser Ala Leu Leu 1365 1370 1375 GCC ACG TAC GGG CGT GAG CGG GTG GGC GAC CCC TTG TGG CTC GGG TCG 4531 Ala Thr Tyr Gly Arg Glu Arg Val Gly Asp Pro Leu Trp Leu Gly Ser 1380 1385 1390 CTG AAG TCC AAC GTC GGT CAC ACC CAG GCC GCC GCG GGG GCC GCG GGT 4579 Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Ala Ala Gly 1395 1400 1405 1410 GTG GTC AAG ATG CTG CTT GCC CTG GAG CAC GGC ACG CTG CCG CGG ACA 4627 Val Val Lys Met Leu Leu Ala Leu Glu His Gly Thr Leu Pro Arg Thr 1415 1420 1425 CTT CAC GCG GAC CGG CCC AGC ACG CAC GTC GAC TGG TCG TCG GGC ACC 4675 Leu His Ala Asp Arg Pro Ser Thr His Val Asp Trp Ser Ser Gly Thr 1430 1435 1440 GTC GCC CTG CTG GCA GAG GCG CGC CGG TGG CCC CGG CGG TCG GAC CGC 4723 Val Ala Leu Leu Ala Glu Ala Arg Arg Trp Pro Arg Arg Ser Asp Arg 1445 1450 1455 CCG CGC CGG GCG GCT GTG TCG TCG TTC GGG ATC AGT GGG ACG AAC GCG 4771 Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr Asn Ala 1460 1465 1470 CAT CTG ATC ATC GAG GAG GCG CCG GAG TGG GTC GAG GAC ATC GAC GGC 4819 His Leu Ile Ile Glu Glu Ala Pro Glu Trp Val Glu Asp Ile Asp Gly 1475 1480 1485 1490 GTC GCT GCT CCT GAC CGC GGT ACC GCG GAC GCG GCT GCT CCG TCG CCG 4867 Val Ala Ala Pro Asp Arg Gly Thr Ala Asp Ala Ala Ala Pro Ser Pro 1495 1500 1505 CTG TTG TTG TCC GCG CGG TCG GAG GGG GCG TTG CGG GCG CAG GCG GTG 4915 Leu Leu Leu Ser Ala Arg Ser Glu Gly Ala Leu Arg Ala Gln Ala Val 1510 1515 1520 CGG TTG GGT GAG TAC GTG GAG CGG GTG GGT GCG GAT CCG CGG GAT GTG 4963 Arg Leu Gly Glu Tyr Val Glu Arg Val Gly Ala Asp Pro Arg Asp Val 1525 1530 1535 GCT TAT TCG CTG GCT TCG ACG CGG ACT CTT TTC GAG CAC CGT GCG GTG 5011 Ala Tyr Ser Leu Ala Ser Thr Arg Thr Leu Phe Glu His Arg Ala Val 1540 1545 1550 GTG CCG TGT GGT GGG CGT GGG GAG CTC GTC GCT GCT CTT GGT GGG TTT 5059 Val Pro Cys Gly Gly Arg Gly Glu Leu Val Ala Ala Leu Gly Gly Phe 1555 1560 1565 1570 GCT GCC GGG AGG GTG TCT GGG GGT GTG CGG TCC GGG CGG GCT GTG CCG 5107 Ala Ala Gly Arg Val Ser Gly Gly Val Arg Ser Gly Arg Ala Val Pro 1575 1580 1585 GGT GGG GTG GGG GTG TTG TTC ACG GGT CAG GGT GCG CAG TGG GTT GGT 5155 Gly Gly Val Gly Val Leu Phe Thr Gly Gln Gly Ala Gln Trp Val Gly 1590 1595 1600 ATG GGG CGT GGG TTG TAT GCG GGG GGT GGG GTG TTT GCG GAG GTG CTG 5203 Met Gly Arg Gly Leu Tyr Ala Gly Gly Gly Val Phe Ala Glu Val Leu 1605 1610 1615 GAT GAG GTG TTG TCG ATG GTG GGG GAG GTG GAT GGT CGG TCG TTG CGG 5251 Asp Glu Val Leu Ser Met Val Gly Glu Val Asp Gly Arg Ser Leu Arg 1620 1625 1630 GAT GTG ATG TTC GGC GAC GTC GAC GTG GAC GCG GGT GCC GGG GCT GAT 5299 Asp Val Met Phe Gly Asp Val Asp Val Asp Ala Gly Ala Gly Ala Asp 1635 1640 1645 1650 GCG GGT GCC GGT GCG GGT GCT GGG GTC GGT TCT GGT TCC GGT TCT GTG 5347 Ala Gly Ala Gly Ala Gly Ala Gly Val Gly Ser Gly Ser Gly Ser Val 1655 1660 1665 GGT GGG TTG TTG GGT CGG ACG GAG TTT GCT CAG CCT GCG CTG TTT GCG 5395 Gly Gly Leu Leu Gly Arg Thr Glu Phe Ala Gln Pro Ala Leu Phe Ala 1670 1675 1680 TTG GAG GTG GCG TTG TTC CGG GCG TTG GAG GCT CGG GGT GTG GAG GTG 5443 Leu Glu Val Ala Leu Phe Arg Ala Leu Glu Ala Arg Gly Val Glu Val 1685 1690 1695 TCG GTG GTG TTG GGT CAT TCG GTG GGG GAG GTG GCT GCT GCG TAT GTG 5491 Ser Val Val Leu Gly His Ser Val Gly Glu Val Ala Ala Ala Tyr Val 1700 1705 1710 GCG GGG GTG TTG TCG TTG GGT GAT GCG GTG CGG TTG GTG GTG GCG CGG 5539 Ala Gly Val Leu Ser Leu Gly Asp Ala Val Arg Leu Val Val Ala Arg 1715 1720 1725 1730 GGT GGG TTG ATG GGT GGG TTG CCG GTG GGT GGG GGG ATG TGG TCG GTG 5587 Gly Gly Leu Met Gly Gly Leu Pro Val Gly Gly Gly Met Trp Ser Val 1735 1740 1745 GGG GCG TCG GAG TCG GTG GTG CGG GGG GTT GTT GAG GGG TTG GGG GAG 5635 Gly Ala Ser Glu Ser Val Val Arg Gly Val Val Glu Gly Leu Gly Glu 1750 1755 1760 TGG GTG TCG GTT GCG GCG GTG AAT GGG CCG CGG TCG GTG GTG TTG TCG 5683 Trp Val Ser Val Ala Ala Val Asn Gly Pro Arg Ser Val Val Leu Ser 1765 1770 1775 GGT GAT GTG GGT GTG CTG GAG TCG GTG GTT GCC TCG CTG ATG GGG GAT 5731 Gly Asp Val Gly Val Leu Glu Ser Val Val Ala Ser Leu Met Gly Asp 1780 1785 1790 GGG GTG GAG TGC CGG CGG TTG GAT GTG TCG CAT GGG TTT CAT TCG GTG 5779 Gly Val Glu Cys Arg Arg Leu Asp Val Ser His Gly Phe His Ser Val 1795 1800 1805 1810 TTG ATG GAG CCG GTG TTG GGG GAG TTC CGG GGG GTT GTG GAG TCG TTG 5827 Leu Met Glu Pro Val Leu Gly Glu Phe Arg Gly Val Val Glu Ser Leu 1815 1820 1825 GAG TTC GGT CGG GTG CGG CCG GGT GTG GTG GTG GTG TCG GGT GTG TCG 5875 Glu Phe Gly Arg Val Arg Pro Gly Val Val Val Val Ser Gly Val Ser 1830 1835 1840 GGT GGG GTG GTG GGT TCG GGG GAG TTG GGG GAT CCG GGG TAT TGG GTG 5923 Gly Gly Val Val Gly Ser Gly Glu Leu Gly Asp Pro Gly Tyr Trp Val 1845 1850 1855 CGT CAT GCG CGG GAG GCG GTG CGT TTC GCG GAT GGG GTG GGG GTG GTG 5971 Arg His Ala Arg Glu Ala Val Arg Phe Ala Asp Gly Val Gly Val Val 1860 1865 1870 CGT GGT CTG GGT GTG GGG ACG TTG GTG GAG GTG GGT CCG CAT GGG GTG 6019 Arg Gly Leu Gly Val Gly Thr Leu Val Glu Val Gly Pro His Gly Val 1875 1880 1885 1890 CTG ACG GGG ATG GCG GGT GAG TGC CTG GGG GCC GGT GAT GAT GTG GTG 6067 Leu Thr Gly Met Ala Gly Glu Cys Leu Gly Ala Gly Asp Asp Val Val 1895 1900 1905 GTG GTG CCG GCG ATG CGG CGG GGC CGT GCG GAG CGG GAG GTG TTC GAG 6115 Val Val Pro Ala Met Arg Arg Gly Arg Ala Glu Arg Glu Val Phe Glu 1910 1915 1920 GCG GCG CTG GCG ACG GTG TTC ACC CGG GAC GCC GGC CTG GAC GCC ACG 6163 Ala Ala Leu Ala Thr Val Phe Thr Arg Asp Ala Gly Leu Asp Ala Thr 1925 1930 1935 GCA CTC CAC ACC GGG AGC ACC GGC CGG CGC ATC GAC CTC CCC ACC TAC 6211 Ala Leu His Thr Gly Ser Thr Gly Arg Arg Ile Asp Leu Pro Thr Tyr 1940 1945 1950 CCC TTC CAA CGC GAC CGC TAC TGG CTG GAC CCC GTT CGC ACC GCC GTG 6259 Pro Phe Gln Arg Asp Arg Tyr Trp Leu Asp Pro Val Arg Thr Ala Val 1955 1960 1965 1970 ACC GGC GTC GAG CCC GCC GGC TCG CCG GCG GAC GCT CGG GCC ACT GAG 6307 Thr Gly Val Glu Pro Ala Gly Ser Pro Ala Asp Ala Arg Ala Thr Glu 1975 1980 1985 CGG GGA CGG TCG ACG ACG GCC GGG ATC CGC TAC CGC GTC GCT TGG CAG 6355 Arg Gly Arg Ser Thr Thr Ala Gly Ile Arg Tyr Arg Val Ala Trp Gln 1990 1995 2000 CCG GCC GTC GTC GAC CGC GGC AAC CCC GGG CCT GCC GGT CAT GTG CTG 6403 Pro Ala Val Val Asp Arg Gly Asn Pro Gly Pro Ala Gly His Val Leu 2005 2010 2015 CTT CTG GCC CCG GAC GAG GAC ACG GCC GAC TCC GGA CTC GCC CCC GCG 6451 Leu Leu Ala Pro Asp Glu Asp Thr Ala Asp Ser Gly Leu Ala Pro Ala 2020 2025 2030 ATC GCA CGT GAA CTC GCC GTG CGC GGG GCC GAG GTC CAC ACC GTC GCC 6499 Ile Ala Arg Glu Leu Ala Val Arg Gly Ala Glu Val His Thr Val Ala 2035 2040 2045 2050 GTG CCG GTC GGT ACA GGC CGG GAG GCA GCC GGG GAC CTG TTG CGG GCC 6547 Val Pro Val Gly Thr Gly Arg Glu Ala Ala Gly Asp Leu Leu Arg Ala 2055 2060 2065 GCC GGT GAC GGT GCC GCC CGC AGC ACC CGA GTT CTG TGG CTC GCC CCG 6595 Ala Gly Asp Gly Ala Ala Arg Ser Thr Arg Val Leu Trp Leu Ala Pro 2070 2075 2080 GCC GAG CCG GAC GCG GCC GAC GCC GTC GCC CTC GTC CAG GCG CTG GGC 6643 Ala Glu Pro Asp Ala Ala Asp Ala Val Ala Leu Val Gln Ala Leu Gly 2085 2090 2095 GAG GCG GTA CCC GAA GCC CCG CTC TGG ATC ACC ACC CGT GAG GCG GCG 6691 Glu Ala Val Pro Glu Ala Pro Leu Trp Ile Thr Thr Arg Glu Ala Ala 2100 2105 2110 GCC GTG CGG CCG GAC GAG ACC CCT TCC GTC GGG GGC GCT CAG CTG TGG 6739 Ala Val Arg Pro Asp Glu Thr Pro Ser Val Gly Gly Ala Gln Leu Trp 2115 2120 2125 2130 GGA CTC GGA CAG GTC GCC GCG CTC GAA CTG GGG CGG CGC TGG GGC GGC 6787 Gly Leu Gly Gln Val Ala Ala Leu Glu Leu Gly Arg Arg Trp Gly Gly 2135 2140 2145 TTG GCG GAC CTG CCC GGG AGT GCG TCG CCC GCG GTG CTC CGT ACG TTC 6835 Leu Ala Asp Leu Pro Gly Ser Ala Ser Pro Ala Val Leu Arg Thr Phe 2150 2155 2160 GTC GGG GCG CTG CTC GCC GGG GGA GAG AAC CAG TTC GCG GTA CGG CCC 6883 Val Gly Ala Leu Leu Ala Gly Gly Glu Asn Gln Phe Ala Val Arg Pro 2165 2170 2175 TCC GGC GTC CAT GTC CGC CGT GTG GTT CCC GCG CCC GTC CCC GTC CCG 6931 Ser Gly Val His Val Arg Arg Val Val Pro Ala Pro Val Pro Val Pro 2180 2185 2190 GCC TCC GCT CGC ACC GTC ACC ACG GCC CCC GCC ACC GCC GTC GGC GAG 6979 Ala Ser Ala Arg Thr Val Thr Thr Ala Pro Ala Thr Ala Val Gly Glu 2195 2200 2205 2210 GAC GCA CGG AAC GAC ACC TCG GAC GTG GTC GTG CCG GAC GAC CGG TGG 7027 Asp Ala Arg Asn Asp Thr Ser Asp Val Val Val Pro Asp Asp Arg Trp 2215 2220 2225 TCC TCC GGC ACC GTA CTG ATC ACC GGG GGC ACC GGT GCC CTG GGT GCG 7075 Ser Ser Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Ala Leu Gly Ala 2230 2235 2240 CAG GTC GCC CGC AGG CTC GCC CGG TCG GGC GCC GCG CGT CTG CTC CTG 7123 Gln Val Ala Arg Arg Leu Ala Arg Ser Gly Ala Ala Arg Leu Leu Leu 2245 2250 2255 GTG GGC CGG CGC GGC GCG GCC GGC CCC GGA GTG GGC GAA CTC GTC GAG 7171 Val Gly Arg Arg Gly Ala Ala Gly Pro Gly Val Gly Glu Leu Val Glu 2260 2265 2270 GAG CTG ACG GCG CTC GGT TCC GAA GTG GCC GTC GAG GCC TGC GAC GTC 7219 Glu Leu Thr Ala Leu Gly Ser Glu Val Ala Val Glu Ala Cys Asp Val 2275 2280 2285 2290 GCC GAC CGG GAC GCA CTG GCC GCG CTC CTC GCG GGC CTC CCC GAG GAG 7267 Ala Asp Arg Asp Ala Leu Ala Ala Leu Leu Ala Gly Leu Pro Glu Glu 2295 2300 2305 CGG CCC CTC GTC GCC GTA CTG CAC GCG GCA GGT GTG CTC GAC GAC GGT 7315 Arg Pro Leu Val Ala Val Leu His Ala Ala Gly Val Leu Asp Asp Gly 2310 2315 2320 GTG CTC GAC TCG CTC ACC TCC GAC CGG GTG GAC GCC GTA CTG CGG GAC 7363 Val Leu Asp Ser Leu Thr Ser Asp Arg Val Asp Ala Val Leu Arg Asp 2325 2330 2335 AAG GTC ACC GCC GCC CGT CAC CTG GAC GAG CTG ACC GCG GAC CTT CCG 7411 Lys Val Thr Ala Ala Arg His Leu Asp Glu Leu Thr Ala Asp Leu Pro 2340 2345 2350 CTC GAC GCC TTC GTG CTC TTC TCC TCC ATC GTC GGC GTG TGG GGC AAC 7459 Leu Asp Ala Phe Val Leu Phe Ser Ser Ile Val Gly Val Trp Gly Asn 2355 2360 2365 2370 GGA GGG CAG GCC GTC TAC GCG GCC GCC AAC GCC GCG CTC GAC GCC CTG 7507 Gly Gly Gln Ala Val Tyr Ala Ala Ala Asn Ala Ala Leu Asp Ala Leu 2375 2380 2385 GCG CAG CGG CGC CGG GCC AGG GGA GCC CGT GCC GCC TCG ATC GCC TGG 7555 Ala Gln Arg Arg Arg Ala Arg Gly Ala Arg Ala Ala Ser Ile Ala Trp 2390 2395 2400 GGG CCG TGG GCC GGT GCC GGA ATG GCC TCC GGA ACG GCG GCG AAG TCC 7603 Gly Pro Trp Ala Gly Ala Gly Met Ala Ser Gly Thr Ala Ala Lys Ser 2405 2410 2415 TTC GAA CGG GAC GGC GTC ACG GCC CTG GAC CCC GAG CGC GCG CTC GAC 7651 Phe Glu Arg Asp Gly Val Thr Ala Leu Asp Pro Glu Arg Ala Leu Asp 2420 2425 2430 GTC CTC GAC GAC GTG GTG GGC GCC GGC GGG ACC TCT GCC GCA GGG ACG 7699 Val Leu Asp Asp Val Val Gly Ala Gly Gly Thr Ser Ala Ala Gly Thr 2435 2440 2445 2450 CAC GCG GCC GGC GAG AGC TCC CTG CTC GTC GCC GAC GTG GAC TGG GAG 7747 His Ala Ala Gly Glu Ser Ser Leu Leu Val Ala Asp Val Asp Trp Glu 2455 2460 2465 ACC TTC GTC GGG CGT TCG GTC ACC CGC CGT ACC TGG TCG CTC TTC GAC 7795 Thr Phe Val Gly Arg Ser Val Thr Arg Arg Thr Trp Ser Leu Phe Asp 2470 2475 2480 GGC GTC TCC GCC GCC CGT TCG GCG CGT GCC GGC CAT GCC GCG GAC GAC 7843 Gly Val Ser Ala Ala Arg Ser Ala Arg Ala Gly His Ala Ala Asp Asp 2485 2490 2495 CGT GCC GCT CTC ACC CCA GGG ACG CGG CCG GGC GAC GGC GCA CCG GGC 7891 Arg Ala Ala Leu Thr Pro Gly Thr Arg Pro Gly Asp Gly Ala Pro Gly 2500 2505 2510 GGG AGC GGA CAG GAC GGG GGC GAG GGC CGG CCG TGG CTC TCC GTC GGC 7939 Gly Ser Gly Gln Asp Gly Gly Glu Gly Arg Pro Trp Leu Ser Val Gly 2515 2520 2525 2530 CCC TCG CCG GCG GAA CGC CGT CGT GCT CTG CTC ACG CTT GTG CGC TCG 7987 Pro Ser Pro Ala Glu Arg Arg Arg Ala Leu Leu Thr Leu Val Arg Ser 2535 2540 2545 GAG GCC GCC GGG ATC CTG CGC CAC GCC TCG GCC GAC GCG GTC GAC CCG 8035 Glu Ala Ala Gly Ile Leu Arg His Ala Ser Ala Asp Ala Val Asp Pro 2550 2555 2560 GAG CTG GCC TTC CGG TCC GCC GGG TTC GAC TCC CTC ACC GTT CTC GAA 8083 Glu Leu Ala Phe Arg Ser Ala Gly Phe Asp Ser Leu Thr Val Leu Glu 2565 2570 2575 CTG CGT AAC CGC CTG ACC GCT GCC ACC GGC CTG AAC CTG CCG AAC ACG 8131 Leu Arg Asn Arg Leu Thr Ala Ala Thr Gly Leu Asn Leu Pro Asn Thr 2580 2585 2590 CTG CTC TTC GAC CAC CCG ACC CCC CTC TCG CTC GCC TCC CAC CTG CAC 8179 Leu Leu Phe Asp His Pro Thr Pro Leu Ser Leu Ala Ser His Leu His 2595 2600 2605 2610 GAC GAA CTG TTC GGT CCC GAC AGC GAG GCG GAG CCG GCA GCG GCC GCC 8227 Asp Glu Leu Phe Gly Pro Asp Ser Glu Ala Glu Pro Ala Ala Ala Ala 2615 2620 2625 CCC ACG CCG GTC ATG GCC GAC GAG CGT GAG CCG ATC GCG ATC GTG GGC 8275 Pro Thr Pro Val Met Ala Asp Glu Arg Glu Pro Ile Ala Ile Val Gly 2630 2635 2640 ATG GCG TGC CGT TAC CCG GGC GGT GTG GCG TCG CCG GAC GAC CTG TGG 8323 Met Ala Cys Arg Tyr Pro Gly Gly Val Ala Ser Pro Asp Asp Leu Trp 2645 2650 2655 GAC CTG GTG GCC GGT GAC GGG CAC ACG CTC TCC CCG TTC CCG GCC GAC 8371 Asp Leu Val Ala Gly Asp Gly His Thr Leu Ser Pro Phe Pro Ala Asp 2660 2665 2670 CGT GGC TGG GAC GTC GAG GGG CTG TAC GAC CCG GAG CCG GGG GTG CCG 8419 Arg Gly Trp Asp Val Glu Gly Leu Tyr Asp Pro Glu Pro Gly Val Pro 2675 2680 2685 2690 GGC AAG AGC TAT GTA CGG GAA GGC GGG TTC CTG CGT TCC GCG GCC GAG 8467 Gly Lys Ser Tyr Val Arg Glu Gly Gly Phe Leu Arg Ser Ala Ala Glu 2695 2700 2705 TTC GAC GCG GAG TTC TTC GGG ATA TCG CCG CGC GAG GCC ACG GCC ATG 8515 Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Thr Ala Met 2710 2715 2720 GAC CCG CAG CAG CGG TTG CTG CTG GAG ACG TCG TGG GAG GCG CTG GAG 8563 Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala Leu Glu 2725 2730 2735 CGG GCC GGC ATC GTT CCG GAC TCG CTG CGC GGC ACC CGG ACC GGT GTC 8611 Arg Ala Gly Ile Val Pro Asp Ser Leu Arg Gly Thr Arg Thr Gly Val 2740 2745 2750 TTC AGC GGC ATC TCC CAG CAG GAC TAC GCG ACC CAG CTG GGG GAC GCC 8659 Phe Ser Gly Ile Ser Gln Gln Asp Tyr Ala Thr Gln Leu Gly Asp Ala 2755 2760 2765 2770 GCC GAC ACC TAC GGC GGG CAT GTG CTC ACG GGG ACC CTC GGC AGT GTG 8707 Ala Asp Thr Tyr Gly Gly His Val Leu Thr Gly Thr Leu Gly Ser Val 2775 2780 2785 ATC TCC GGT CGG GTT GCC TAT GCG TTG GGG TTG GAG GGG CCG GCG CTG 8755 Ile Ser Gly Arg Val Ala Tyr Ala Leu Gly Leu Glu Gly Pro Ala Leu 2790 2795 2800 ACG GTG GAC ACG GCG TGT TCG TCG TCG TTG GTG GCG TTG CAT CTG GCG 8803 Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His Leu Ala 2805 2810 2815 GTG CAG TCG TTG CGG CGG GGT GAG TGT GAT CTG GCG TTG GCC GGT GGG 8851 Val Gln Ser Leu Arg Arg Gly Glu Cys Asp Leu Ala Leu Ala Gly Gly 2820 2825 2830 GTG ACG GTG ATG GCG ACG CCG ACG GTG TTC GTG GAG TTC TCG CGG CAG 8899 Val Thr Val Met Ala Thr Pro Thr Val Phe Val Glu Phe Ser Arg Gln 2835 2840 2845 2850 CGG GGG CTG GCG GCG GAC GGG CGG TGC AAG GCG TTC GCG GAG GGT GCG 8947 Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Glu Gly Ala 2855 2860 2865 GAC GGG ACG GCG TGG GCG GAG GGT GTG GGT GTG CTG CTG GTG GAG CGG 8995 Asp Gly Thr Ala Trp Ala Glu Gly Val Gly Val Leu Leu Val Glu Arg 2870 2875 2880 CTT TCC GAC GCG CGC CGC AAC GGT CAT CGG GTG CTG GCG GTG GTG CGG 9043 Leu Ser Asp Ala Arg Arg Asn Gly His Arg Val Leu Ala Val Val Arg 2885 2890 2895 GGC AGT GCG GTC AAT CAG GAC GGT GCG AGC AAT GGG CTG ACG GCG CCG 9091 Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr Ala Pro 2900 2905 2910 AGT GGT CCG GCG CAG CAG CGG GTG ATC CGT GAG GCG CTG GCT GAT GCG 9139 Ser Gly Pro Ala Gln Gln Arg Val Ile Arg Glu Ala Leu Ala Asp Ala 2915 2920 2925 2930 GGG CTG GTG CCC GCC GAC GTG GAT GTG GTG GAG GCG CAC GGT ACG GGG 9187 Gly Leu Val Pro Ala Asp Val Asp Val Val Glu Ala His Gly Thr Gly 2935 2940 2945 ACG GCG CTG GGT GAT CCG ATC GAG GCG GGT GCG CTG CTG GCC ACG TAC 9235 Thr Ala Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu Leu Ala Thr Tyr 2950 2955 2960 GGG CGG GAG CGG GTC GGC GAT CCG TTG TGG CTC GGG TCG TTG AAG TCG 9283 Gly Arg Glu Arg Val Gly Asp Pro Leu Trp Leu Gly Ser Leu Lys Ser 2965 2970 2975 AAC ATC GGG CAT GCG CAG GCG GCT GCG GGT GTG GGT GGT GTG ATC AAG 9331 Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Gly Gly Val Ile Lys 2980 2985 2990 GTG GTG CAG GGG ATG CGG CAT GGG TCG TTG CCG CGG ACG CTG CAT GTG 9379 Val Val Gln Gly Met Arg His Gly Ser Leu Pro Arg Thr Leu His Val 2995 3000 3005 3010 GAT GCG CCG TCG TCG AAG GTG GAG TGG GCT TCG GGT GCG GTG GAG CTG 9427 Asp Ala Pro Ser Ser Lys Val Glu Trp Ala Ser Gly Ala Val Glu Leu 3015 3020 3025 CTG ACC GAG ACC CGG TCG TGG CCG CGG CGG GTG GAG CGG GTG CGG CGG 9475 Leu Thr Glu Thr Arg Ser Trp Pro Arg Arg Val Glu Arg Val Arg Arg 3030 3035 3040 GCC GCG GTG TCG GCG TTC GGG GTG AGC GGG ACC AAC GCC CAT GTG GTC 9523 Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His Val Val 3045 3050 3055 CTG GAG GAA GCG CCG GCG GAG GCC GGG AGC GAG CAC GGG GAC GGC CCT 9571 Leu Glu Glu Ala Pro Ala Glu Ala Gly Ser Glu His Gly Asp Gly Pro 3060 3065 3070 GAA CCT GAG CGG CCC GAC GCG GTG ACG GGT CCG TTG TCG TGG GTG CTT 9619 Glu Pro Glu Arg Pro Asp Ala Val Thr Gly Pro Leu Ser Trp Val Leu 3075 3080 3085 3090 TCT GCG CGG TCG GAG GGG GCG TTG CGG GCG CAG GCG GTG CGG TTG CGT 9667 Ser Ala Arg Ser Glu Gly Ala Leu Arg Ala Gln Ala Val Arg Leu Arg 3095 3100 3105 GAG TGT GTG GAG CGG GTG GGT GCG GAT CCG CGG GAT GTG GCG GGG TCG 9715 Glu Cys Val Glu Arg Val Gly Ala Asp Pro Arg Asp Val Ala Gly Ser 3110 3115 3120 TTG GTG GTG TCG CGT GCG TCG TTC GGT GAG CGT GCG GTG GTG GTG GGC 9763 Leu Val Val Ser Arg Ala Ser Phe Gly Glu Arg Ala Val Val Val Gly 3125 3130 3135 CGG GGG CGT GAG GAG TTG CTG GCG GGT CTG GAT GTG GTG GCT GCC GGG 9811 Arg Gly Arg Glu Glu Leu Leu Ala Gly Leu Asp Val Val Ala Ala Gly 3140 3145 3150 GCT CCT GTG GGT GTG TCT TCG GGG GCC GGT GCT GTG GTG CGG GGG AGT 9859 Ala Pro Val Gly Val Ser Ser Gly Ala Gly Ala Val Val Arg Gly Ser 3155 3160 3165 3170 GCG GTG CGG GGT CGT GGG GTG GGG GTG TTG TTC ACG GGT CAG GGT GCG 9907 Ala Val Arg Gly Arg Gly Val Gly Val Leu Phe Thr Gly Gln Gly Ala 3175 3180 3185 CAG TGG GTT GGT ATG GGG CGT GGG TTG TAT GCG GGG GGT GGG GTG TTT 9955 Gln Trp Val Gly Met Gly Arg Gly Leu Tyr Ala Gly Gly Gly Val Phe 3190 3195 3200 GCG GAG GTG CTG GAT GAG GTG TTG TCG GTG GTG GGG GAG GTG GAT GGT 10003 Ala Glu Val Leu Asp Glu Val Leu Ser Val Val Gly Glu Val Asp Gly 3205 3210 3215 CGG TCG TTG CGG GAT GTG ATG TTC GCG GAT GCT GAC TCG GTT TTG GGT 10051 Arg Ser Leu Arg Asp Val Met Phe Ala Asp Ala Asp Ser Val Leu Gly 3220 3225 3230 GGG TTG TTG GGT CGG ACG GAG TTT GCT CAG CCT GCG TTG TTT GCG TTG 10099 Gly Leu Leu Gly Arg Thr Glu Phe Ala Gln Pro Ala Leu Phe Ala Leu 3235 3240 3245 3250 GAG GTG GCG TTG TTC CGG GCG TTG GAG GCT CGG GGT GTG GAG GTG TCG 10147 Glu Val Ala Leu Phe Arg Ala Leu Glu Ala Arg Gly Val Glu Val Ser 3255 3260 3265 GTG GTG TTG GGT CAT TCG GTG GGG GAG GTG GCT GCT GCG TAT GTG GCG 10195 Val Val Leu Gly His Ser Val Gly Glu Val Ala Ala Ala Tyr Val Ala 3270 3275 3280 GGG GTG TTG TCG TTG GGT GAT GCG GTG CGG TTG GTG GTG GCG CGG GGT 10243 Gly Val Leu Ser Leu Gly Asp Ala Val Arg Leu Val Val Ala Arg Gly 3285 3290 3295 GGG TTG ATG GGT GGG TTG CCG GTG GGT GGG GGG ATG TGG TCG GTG GGG 10291 Gly Leu Met Gly Gly Leu Pro Val Gly Gly Gly Met Trp Ser Val Gly 3300 3305 3310 GCG TCG GAG TCG GTG GTG CGG GGG GTT GTT GAG GGG TTG GGG GAG TGG 10339 Ala Ser Glu Ser Val Val Arg Gly Val Val Glu Gly Leu Gly Glu Trp 3315 3320 3325 3330 GTG TCG GTT GCG GCG GTG AAT GGG CCG CGG TCG GTG GTG TTG TCG GGT 10387 Val Ser Val Ala Ala Val Asn Gly Pro Arg Ser Val Val Leu Ser Gly 3335 3340 3345 GAT GTG GGT GTG CTG GAG TCG GTG GTT GTC ACG CTG ATG GGG GAT GGG 10435 Asp Val Gly Val Leu Glu Ser Val Val Val Thr Leu Met Gly Asp Gly 3350 3355 3360 GTG GAG TGC CGG CGG TTG GAT GTG TCG CAT GGG TTT CAT TCG GTG TTG 10483 Val Glu Cys Arg Arg Leu Asp Val Ser His Gly Phe His Ser Val Leu 3365 3370 3375 ATG GAG CCG GTG TTG GGG GAG TTC CGG GGG GTT GTG GAG TCG TTG GAG 10531 Met Glu Pro Val Leu Gly Glu Phe Arg Gly Val Val Glu Ser Leu Glu 3380 3385 3390 TTC GGT CGG GTG CGG CCG GGT GTG GTG GTG GTG TCG GGT GTG TCG GGT 10579 Phe Gly Arg Val Arg Pro Gly Val Val Val Val Ser Gly Val Ser Gly 3395 3400 3405 3410 GGG GTG GTG GGT TCG GGG GAG TTG GGG GAT CCG GGG TAT TGG GTG CGT 10627 Gly Val Val Gly Ser Gly Glu Leu Gly Asp Pro Gly Tyr Trp Val Arg 3415 3420 3425 CAT GCG CGG GAG GCG GTG CGT TTC GCG GAT GGG GTG GGG GTG GTG CGT 10675 His Ala Arg Glu Ala Val Arg Phe Ala Asp Gly Val Gly Val Val Arg 3430 3435 3440 GGT CTG GGT GTG GGG ACG TTG GTG GAG GTG GGT CCG CAT GGG GTG CTG 10723 Gly Leu Gly Val Gly Thr Leu Val Glu Val Gly Pro His Gly Val Leu 3445 3450 3455 ACG GGG ATG GCG GGT CAG TGC CTG GAG GCC GGT GAT GAT GTG GTG GTG 10771 Thr Gly Met Ala Gly Gln Cys Leu Glu Ala Gly Asp Asp Val Val Val 3460 3465 3470 GTG CCG GCG ATG CGG CGG GGC CGT CCG GAG CGG GAG GTG TTC GAG GCG 10819 Val Pro Ala Met Arg Arg Gly Arg Pro Glu Arg Glu Val Phe Glu Ala 3475 3480 3485 3490 GCG CTG GCG ACG GTG TTC ACC CGG GAC GCC GGC CTC GAC GCC ACG ACA 10867 Ala Leu Ala Thr Val Phe Thr Arg Asp Ala Gly Leu Asp Ala Thr Thr 3495 3500 3505 CTC CAC ACC GGG AGC ACC GGC CGA CGC ATC GAC CTC CCC ACC TAC CCC 10915 Leu His Thr Gly Ser Thr Gly Arg Arg Ile Asp Leu Pro Thr Tyr Pro 3510 3515 3520 TTC CAA CAC AAC CGC TAC TGG GCA ACC GGC TCA GTG ACC GGT GCG ACC 10963 Phe Gln His Asn Arg Tyr Trp Ala Thr Gly Ser Val Thr Gly Ala Thr 3525 3530 3535 GGC ACC TCG GCA GCC GCG CGC TTC GGC CTG GAG TGG AAG GAC CAC CCC 11011 Gly Thr Ser Ala Ala Ala Arg Phe Gly Leu Glu Trp Lys Asp His Pro 3540 3545 3550 TTC CTC AGC GGC GCC ACG CCG ATA GCC GGC TCC GGC GCG CTG CTC CTC 11059 Phe Leu Ser Gly Ala Thr Pro Ile Ala Gly Ser Gly Ala Leu Leu Leu 3555 3560 3565 3570 ACC GGC AGG GTG GGG CTC GCT GCC CAC CCG TGG CTG GCC GAC CAC GCC 11107 Thr Gly Arg Val Gly Leu Ala Ala His Pro Trp Leu Ala Asp His Ala 3575 3580 3585 ATC TCC GGC ACG GTG CTG CTC CCC GGA ACG GCG ATC GCC GAC CTG CTG 11155 Ile Ser Gly Thr Val Leu Leu Pro Gly Thr Ala Ile Ala Asp Leu Leu 3590 3595 3600 CTG CGG GCG GTC GAG GAG GTC GGC GCC GGA GGG GTC GAG GAA CTG ACG 11203 Leu Arg Ala Val Glu Glu Val Gly Ala Gly Gly Val Glu Glu Leu Thr 3605 3610 3615 CTC CAT GAG CCC CTG CTC CTC CCC GAG CGA GGC GGC CTG CAC GTC CAG 11251 Leu His Glu Pro Leu Leu Leu Pro Glu Arg Gly Gly Leu His Val Gln 3620 3625 3630 GTG CTG GTC GAG GCG GCC GAC GAG CAG GGA CGG CGT GCC GTG GCA GTC 11299 Val Leu Val Glu Ala Ala Asp Glu Gln Gly Arg Arg Ala Val Ala Val 3635 3640 3645 3650 GCC GCA CGC CCG GAG GGC CCT GGG CGG GAC GGT GAG GAA CAG GAG TGG 11347 Ala Ala Arg Pro Glu Gly Pro Gly Arg Asp Gly Glu Glu Gln Glu Trp 3655 3660 3665 ACC CGG CAC GCG GAA GGC GTG CTC ACC TCC ACC GAG ACG GCC GTT CCG 11395 Thr Arg His Ala Glu Gly Val Leu Thr Ser Thr Glu Thr Ala Val Pro 3670 3675 3680 GAC ATG GGC TGG GCC GCC GGG GCC TGG CCG CCG CCC GGT GCC GAG CCG 11443 Asp Met Gly Trp Ala Ala Gly Ala Trp Pro Pro Pro Gly Ala Glu Pro 3685 3690 3695 ATC GAC GTC GAG GAG CTG TAC GAC GCG TTC GCC GCG GAC GGC TAC GGC 11491 Ile Asp Val Glu Glu Leu Tyr Asp Ala Phe Ala Ala Asp Gly Tyr Gly 3700 3705 3710 TAC GGC CCG GCC TTC ACC GCA CTG TCC GGC GTG TGG CGT CTC GGC GAC 11539 Tyr Gly Pro Ala Phe Thr Ala Leu Ser Gly Val Trp Arg Leu Gly Asp 3715 3720 3725 3730 GAA CTC TTC GCC GAG GTG CGG CGG CCC GCG GGG GGC GCG GGC ACG ACC 11587 Glu Leu Phe Ala Glu Val Arg Arg Pro Ala Gly Gly Ala Gly Thr Thr 3735 3740 3745 GGT GAC GGT TTC GGC GTC CAC CCC GCA CTC TTC GAT GCG GCC CTC CAC 11635 Gly Asp Gly Phe Gly Val His Pro Ala Leu Phe Asp Ala Ala Leu His 3750 3755 3760 CCG TGG CGC GCC GGC GGG CTG CTG CCC GAC ACG GGC GGC ACC ACC TGG 11683 Pro Trp Arg Ala Gly Gly Leu Leu Pro Asp Thr Gly Gly Thr Thr Trp 3765 3770 3775 GCG CCG TTC TCC TGG CAG GGC ATC GCG CTC CAC ACC ACC GGA GCC GAG 11731 Ala Pro Phe Ser Trp Gln Gly Ile Ala Leu His Thr Thr Gly Ala Glu 3780 3785 3790 ACG CTC CGC GTC AGA CTG GCC CCT GCG GCC GGC GGC ACC GAG TCG GCC 11779 Thr Leu Arg Val Arg Leu Ala Pro Ala Ala Gly Gly Thr Glu Ser Ala 3795 3800 3805 3810 TTC TCC GTA CAG GCC GCC GAC CCG GCG GGC ACC CCG GTC CTC ACC CTC 11827 Phe Ser Val Gln Ala Ala Asp Pro Ala Gly Thr Pro Val Leu Thr Leu 3815 3820 3825 GAC GCA CTG CTG CTC CGC CCG GTG ACC CTG GGG AGG GCC GAC GCG CCG 11875 Asp Ala Leu Leu Leu Arg Pro Val Thr Leu Gly Arg Ala Asp Ala Pro 3830 3835 3840 CAA CCG CTG TAC CGC GTC GAC TGG CAG CCG GTC GGC CAG GGG ACC GAG 11923 Gln Pro Leu Tyr Arg Val Asp Trp Gln Pro Val Gly Gln Gly Thr Glu 3845 3850 3855 GCC TCC GGC GCC CAG GGC TGG ACG GTG CTC GGG CAG GCC GCG GCC GAG 11971 Ala Ser Gly Ala Gln Gly Trp Thr Val Leu Gly Gln Ala Ala Ala Glu 3860 3865 3870 ACG GTC GCG CAG CCC GCC GCC CAT GCG GAC CTC ACC GCC CTG CGT ACG 12019 Thr Val Ala Gln Pro Ala Ala His Ala Asp Leu Thr Ala Leu Arg Thr 3875 3880 3885 3890 GCT GTG GCC GCG GCG GGA ACA CCC GTG CCC CGG CTG GTG GTC GTG TCG 12067 Ala Val Ala Ala Ala Gly Thr Pro Val Pro Arg Leu Val Val Val Ser 3895 3900 3905 CCG GTG GAC ACC CGG CTG GAC GAG GGG CCG GTG CTG GCG GAC GCC GAG 12115 Pro Val Asp Thr Arg Leu Asp Glu Gly Pro Val Leu Ala Asp Ala Glu 3910 3915 3920 GCT CGG GCC CGT GCG GGT GAC GGC TGG GAC GAC GAT CCC CTA CGT GTC 12163 Ala Arg Ala Arg Ala Gly Asp Gly Trp Asp Asp Asp Pro Leu Arg Val 3925 3930 3935 GCC CTC GGG CGC GGC CTG ACC CTG GTC CGG GAG TGG GTC GAG GAC GAA 12211 Ala Leu Gly Arg Gly Leu Thr Leu Val Arg Glu Trp Val Glu Asp Glu 3940 3945 3950 CGG TTG GCG GAC TCC CGG CTC GTC GTC CTC ACC CGT GGC GCG GTG GCG 12259 Arg Leu Ala Asp Ser Arg Leu Val Val Leu Thr Arg Gly Ala Val Ala 3955 3960 3965 3970 GCC GGT CCC GGC GAT GTG CCG GAC CTG ACA GGT GCG GCC CTG TGG GGG 12307 Ala Gly Pro Gly Asp Val Pro Asp Leu Thr Gly Ala Ala Leu Trp Gly 3975 3980 3985 CTG CTC CGC TCC GCG CAG TCG GAG TAT CCG GAC CGC TTC ACC CTC ATC 12355 Leu Leu Arg Ser Ala Gln Ser Glu Tyr Pro Asp Arg Phe Thr Leu Ile 3990 3995 4000 GAC GTG GAC GAT TCC CCC GAG TCC CGT GCG GCT CTG CCC CGG GCT CTG 12403 Asp Val Asp Asp Ser Pro Glu Ser Arg Ala Ala Leu Pro Arg Ala Leu 4005 4010 4015 GGA TCG GCC GAG CGA CAA CTC GCC CTG CGG ACG GGC GAC GTG CTG GCG 12451 Gly Ser Ala Glu Arg Gln Leu Ala Leu Arg Thr Gly Asp Val Leu Ala 4020 4025 4030 CCG GCC CTG GTC CCG ATG GCC ACC CGG CCG GCG GAG ACC ACT CCA GCG 12499 Pro Ala Leu Val Pro Met Ala Thr Arg Pro Ala Glu Thr Thr Pro Ala 4035 4040 4045 4050 ACG GCG GTC GCC TCG GCG ACA ACA CAG ACA CAG GTC ACC GCG CCC GCT 12547 Thr Ala Val Ala Ser Ala Thr Thr Gln Thr Gln Val Thr Ala Pro Ala 4055 4060 4065 CCC GAC GAC CCG GCT GCG GAT GCC GTG TTC GAC CCG GCG GGC ACC GTA 12595 Pro Asp Asp Pro Ala Ala Asp Ala Val Phe Asp Pro Ala Gly Thr Val 4070 4075 4080 CTG ATC ACC GGC GGC ACC GGC GCC CTG GGA CGG CGT GTC GCC TCG CAC 12643 Leu Ile Thr Gly Gly Thr Gly Ala Leu Gly Arg Arg Val Ala Ser His 4085 4090 4095 CTC GCG CGC CGG TAC GGC GTA CGC CAC ATG CTT CTG GTC AGC AGG CGT 12691 Leu Ala Arg Arg Tyr Gly Val Arg His Met Leu Leu Val Ser Arg Arg 4100 4105 4110 GGA CCG GAC GCC CCC GAG GCC GGT CCC CTG GAA CGG GAA CTC GCC GGT 12739 Gly Pro Asp Ala Pro Glu Ala Gly Pro Leu Glu Arg Glu Leu Ala Gly 4115 4120 4125 4130 CTC GGA GTC ACC GCC ACC TTC CTG GCA TGC GAC CTC ACC GAC ATC GAG 12787 Leu Gly Val Thr Ala Thr Phe Leu Ala Cys Asp Leu Thr Asp Ile Glu 4135 4140 4145 GCC GTA CGG AAG GCC GTC GCC GCG GTG CCG TCG GAC CAC CCG CTG ACC 12835 Ala Val Arg Lys Ala Val Ala Ala Val Pro Ser Asp His Pro Leu Thr 4150 4155 4160 GGT GTG GTG CAC ACC GCC GGC GTG CTG GAC GAC GGC GCC CTG ACC GGC 12883 Gly Val Val His Thr Ala Gly Val Leu Asp Asp Gly Ala Leu Thr Gly 4165 4170 4175 CTG ACC CGG CAA CGC CTC GAC ACC GTG CTG CGG CCC AAG GCC GAC GCC 12931 Leu Thr Arg Gln Arg Leu Asp Thr Val Leu Arg Pro Lys Ala Asp Ala 4180 4185 4190 GTG CGG AAC CTC CAC GAG GCG ACC CTC GAC CGG CCG CTG CGC GCG TTC 12979 Val Arg Asn Leu His Glu Ala Thr Leu Asp Arg Pro Leu Arg Ala Phe 4195 4200 4205 4210 GTC CTG TTC TCC GCC GCC GCC GGA CTC CTG GGC CGC CCC GGG CAG GCC 13027 Val Leu Phe Ser Ala Ala Ala Gly Leu Leu Gly Arg Pro Gly Gln Ala 4215 4220 4225 TCC TAC GCC GCC GCC AAC GCG GTC CTC GAC GCG CTC GCG GGA GCC CGC 13075 Ser Tyr Ala Ala Ala Asn Ala Val Leu Asp Ala Leu Ala Gly Ala Arg 4230 4235 4240 CGC GCG GCC GGA CTG CCC GCA GTG TCC CTG GCG TGG GGC CTG TGG GAC 13123 Arg Ala Ala Gly Leu Pro Ala Val Ser Leu Ala Trp Gly Leu Trp Asp 4245 4250 4255 GAG CAG ACG GGC ATG GCA GGA GGC CTC GAC GAG ATG GCC CTG CGC GTG 13171 Glu Gln Thr Gly Met Ala Gly Gly Leu Asp Glu Met Ala Leu Arg Val 4260 4265 4270 CTG CGC CGG GAC GGC ATC GCC GCG ATG CCT CCG GAG CAG GGG CTC GAA 13219 Leu Arg Arg Asp Gly Ile Ala Ala Met Pro Pro Glu Gln Gly Leu Glu 4275 4280 4285 4290 CTG CTC GAC CTG GCC CTG ACC GGA CAC CGG GAC GGA CCC GCC GTC CTC 13267 Leu Leu Asp Leu Ala Leu Thr Gly His Arg Asp Gly Pro Ala Val Leu 4295 4300 4305 GTC CCC CTC CTC CTC GAC GGC GCG GCC CTG CGC CGC ACG GCG AAG GAG 13315 Val Pro Leu Leu Leu Asp Gly Ala Ala Leu Arg Arg Thr Ala Lys Glu 4310 4315 4320 CGC GGC GCG GCC ACG ATG TCC CCC TTG CTG CGC GCC CTG CTG CCC GCC 13363 Arg Gly Ala Ala Thr Met Ser Pro Leu Leu Arg Ala Leu Leu Pro Ala 4325 4330 4335 GCC CTG CGC CGC AGC GGT GGA GCC GGC GCC CCC GCG GCG GCC GAC CGG 13411 Ala Leu Arg Arg Ser Gly Gly Ala Gly Ala Pro Ala Ala Ala Asp Arg 4340 4345 4350 CAC GGC AAG GAG GCG GAC CCC GGT GCG GGA CGC CTC GCA GGG ATG GTG 13459 His Gly Lys Glu Ala Asp Pro Gly Ala Gly Arg Leu Ala Gly Met Val 4355 4360 4365 4370 GCA CTC GAA GCG GCG GAG CGT TCC GCG GCC GTC CTT GAG CTG GTC ACC 13507 Ala Leu Glu Ala Ala Glu Arg Ser Ala Ala Val Leu Glu Leu Val Thr 4375 4380 4385 GAA CAG GTC GCC GAG GTC CTC GGC TAC GCG TCG GCC GCG GAG ATC GAG 13555 Glu Gln Val Ala Glu Val Leu Gly Tyr Ala Ser Ala Ala Glu Ile Glu 4390 4395 4400 CCC GAA CGA CCC TTC CGG GAG ATC GGC GTC GAC TCC CTG GCG GCG GTG 13603 Pro Glu Arg Pro Phe Arg Glu Ile Gly Val Asp Ser Leu Ala Ala Val 4405 4410 4415 GAG CTG CGC AAC CGG CTC AGC CGT CTG GTC GGC CTG CGG TTG CCG ACC 13651 Glu Leu Arg Asn Arg Leu Ser Arg Leu Val Gly Leu Arg Leu Pro Thr 4420 4425 4430 ACG CTG TCC TTC GAC CAC CCC ACG CCG AAG GAC ATG GCG CAG CAC ATC 13699 Thr Leu Ser Phe Asp His Pro Thr Pro Lys Asp Met Ala Gln His Ile 4435 4440 4445 4450 GAC GGG CAG CTC CCC CGC CCG GCC GGA GCC TCG CCC GCG GAC GCA GCG 13747 Asp Gly Gln Leu Pro Arg Pro Ala Gly Ala Ser Pro Ala Asp Ala Ala 4455 4460 4465 CTG GAA GGG ATC GGC GAC CTC GCG CGG GCG GTC GCC CTG CTG GGC ACG 13795 Leu Glu Gly Ile Gly Asp Leu Ala Arg Ala Val Ala Leu Leu Gly Thr 4470 4475 4480 GGC GAC GCC CGC CGG GCC GAG GTA CGA GAG CAG CTC GTC GGA CTG CTG 13843 Gly Asp Ala Arg Arg Ala Glu Val Arg Glu Gln Leu Val Gly Leu Leu 4485 4490 4495 GCC GCG CTC GAC CCA CCT GGG CGG ACG GGC ACC GCC GCA CCC GGC GTC 13891 Ala Ala Leu Asp Pro Pro Gly Arg Thr Gly Thr Ala Ala Pro Gly Val 4500 4505 4510 CCC TCC GGT GCC GAT GGC GCG GAA CCG ACC GTG ACG GAC CGG CTC GAC 13939 Pro Ser Gly Ala Asp Gly Ala Glu Pro Thr Val Thr Asp Arg Leu Asp 4515 4520 4525 4530 GAG GCG ACC GAC GAC GAG ATC TTC GCC TTC CTG GAC GAG CAG CTG TGA 13987 Glu Ala Thr Asp Asp Glu Ile Phe Ala Phe Leu Asp Glu Gln Leu * 4535 4540 4545

【００４８】配列番号：１４配列の長さ：４５４６アミノ酸配列の型：アミノ酸トポロジー：不明配列の種類：蛋白質配列 Met Ser Gly Glu Leu Ala Ile Ser Arg Ser Asp Asp Arg Ser Asp Ala 1 5 10 15 Val Ala Val Val Gly Met Ala Cys Arg Phe Pro Gly Ala Pro Gly Ile 20 25 30 Ala Glu Phe Trp Glu Leu Leu Arg Ser Gly Arg Gly Met Pro Thr Arg 35 40 45 Gln Asp Asp Gly Thr Trp Arg Ala Ala Leu Glu Asp His Ala Gly Phe 50 55 60 Asp Ala Gly Phe Phe Gly Met Asn Ala Arg Gln Ala Ala Ala Thr Asp 65 70 75 80 Pro Gln His Arg Leu Met Leu Glu Leu Gly Trp Glu Ala Leu Glu Asp 85 90 95 Ala Gly Ile Val Pro Gly Asp Leu Thr Gly Thr Asp Thr Gly Val Phe 100 105 110 Ala Gly Val Ala Ser Asp Asp Tyr Ala Val Leu Thr Arg Arg Ser Ala 115 120 125 Val Ser Ala Gly Gly Tyr Thr Ala Thr Gly Leu His Arg Ala Leu Ala 130 135 140 Ala Asn Arg Leu Ser His Phe Leu Gly Leu Arg Gly Pro Ser Leu Val 145 150 155 160 Val Asp Ser Ala Gln Ser Ala Ser Leu Val Ala Val Gln Leu Ala Cys 165 170 175 Glu Ser Leu Arg Arg Gly Glu Thr Ser Leu Ala Val Ala Gly Gly Val 180 185 190 Asn Leu Ile Leu Thr Glu Glu Ser Thr Thr Val Met Glu Arg Met Gly 195 200 205 Ala Leu Ser Pro Asp Gly Arg Cys His Thr Phe Asp Ala Arg Ala Asn 210 215 220 Gly Tyr Val Arg Gly Glu Gly Gly Gly Ala Val Val Leu Lys Pro Leu 225 230 235 240 Asp Ala Ala Leu Ala Asp Gly Asp Arg Val Tyr Cys Val Ile Lys Gly 245 250 255 Gly Ala Val Asn Asn Asp Gly Gly Gly Ala Ser Leu Thr Thr Pro Asp 260 265 270 Arg Glu Ala Gln Glu Ala Val Leu Arg Gln Ala Tyr Arg Arg Ala Gly 275 280 285 Val Ser Thr Gly Ala Val Arg Tyr Val Glu Leu His Gly Thr Gly Thr 290 295 300 Arg Ala Gly Asp Pro Val Glu Ala Ala Ala Leu Gly Ala Val Leu Gly 305 310 315 320 Ala Gly Ala Asp Ser Gly Arg Ser Thr Pro Leu Ala Val Gly Ser Val 325 330 335 Lys Thr Asn Val Gly His Leu Glu Gly Ala Ala Gly Ile Val Gly Leu 340 345 350 Ile Lys Ala Thr Leu Cys Val Arg Lys Gly Glu Leu Val Pro Ser Leu 355 360 365 Asn Phe Ser Thr Pro Asn Pro Asp Ile Pro Leu Asp Asp Leu Arg Leu 370 375 380 Arg Val Gln Thr Glu Arg Gln Glu Trp Asn Glu Glu Asp Asp Arg Pro 385 390 395 400 Arg Val Ala Gly Val Ser Ser Phe Gly Met Gly Gly Thr Asn Val His 405 410 415 Leu Val Ile Ala Glu Ala Pro Ala Ala Ala Gly Ser Ser Gly Ala Gly 420 425 430 Gly Ser Gly Ala Gly Ser Gly Ala Gly Ile Ser Ala Val Ser Gly Val 435 440 445 Val Pro Val Val Val Ser Gly Arg Ser Arg Val Val Val Arg Glu Ala 450 455 460 Ala Gly Arg Leu Ala Glu Val Val Glu Ala Gly Gly Val Gly Leu Ala 465 470 475 480 Asp Val Ala Val Thr Met Ala Asp Arg Ser Arg Phe Gly Tyr Arg Ala 485 490 495 Val Val Leu Ala Arg Gly Glu Ala Glu Leu Ala Gly Arg Leu Arg Ala 500 505 510 Leu Ala Gly Gly Asp Pro Asp Ala Gly Val Val Thr Gly Ala Val Leu 515 520 525 Asp Gly Gly Val Val Val Gly Ala Ala Pro Gly Gly Ala Gly Ala Ala 530 535 540 Gly Gly Ala Gly Ala Ala Gly Gly Ala Gly Gly Gly Gly Val Val Leu 545 550 555 560 Val Phe Pro Gly Gln Gly Thr Gln Trp Val Gly Met Gly Ala Gly Leu 565 570 575 Leu Gly Ser Ser Glu Val Phe Ala Ala Ser Met Arg Glu Cys Ala Arg 580 585 590 Ala Leu Ser Val His Val Gly Trp Asp Leu Leu Glu Val Val Ser Gly 595 600 605 Gly Ala Gly Leu Glu Arg Val Asp Val Val Gln Pro Val Thr Trp Ala 610 615 620 Val Met Val Ser Leu Ala Arg Tyr Trp Gln Ala Met Gly Val Asp Val 625 630 635 640 Ala Ala Val Val Gly His Ser Gln Gly Glu Ile Ala Ala Ala Thr Val 645 650 655 Ala Gly Ala Leu Ser Leu Glu Asp Ala Ala Ala Val Val Ala Leu Arg 660 665 670 Ala Gly Leu Ile Gly Arg Tyr Leu Ala Gly Arg Gly Ala Met Ala Ala 675 680 685 Val Pro Leu Pro Ala Gly Glu Val Glu Ala Gly Leu Ala Lys Trp Pro 690 695 700 Gly Val Glu Val Ala Ala Val Asn Gly Pro Ala Ser Thr Val Val Ser 705 710 715 720 Gly Asp Arg Arg Ala Val Ala Gly Tyr Val Ala Val Cys Gln Ala Glu 725 730 735 Gly Val Gln Ala Arg Leu Ile Pro Val Asp Tyr Ala Ser His Ser Arg 740 745 750 His Val Glu Asp Leu Lys Gly Glu Leu Glu Arg Val Leu Ser Gly Ile 755 760 765 Arg Pro Arg Ser Pro Arg Val Pro Val Cys Ser Thr Val Ala Gly Glu 770 775 780 Gln Pro Gly Glu Pro Val Phe Asp Ala Gly Tyr Trp Phe Arg Asn Leu 785 790 795 800 Arg Asn Arg Val Glu Phe Ser Ala Val Val Gly Gly Leu Leu Glu Glu 805 810 815 Gly His Arg Arg Phe Ile Glu Val Ser Ala His Pro Val Leu Val His 820 825 830 Ala Ile Glu Gln Thr Ala Glu Ala Ala Asp Arg Ser Val His Ala Thr 835 840 845 Gly Thr Leu Arg Arg Gln Asp Asp Ser Pro His Arg Leu Leu Thr Ser 850 855 860 Thr Ala Glu Ala Trp Ala His Gly Ala Thr Leu Thr Trp Asp Pro Ala 865 870 875 880 Leu Pro Pro Gly His Leu Thr Thr Leu Pro Thr Tyr Pro Phe Asn His 885 890 895 His His Tyr Trp Leu Asp Thr Ile Asp Gly Gly Gly Gly Asp Asp Ala 900 905 910 Thr Gln Glu Lys Glu Ser Gly Pro Leu Thr Arg Glu Leu Arg Gly Leu 915 920 925 Pro Ser Ser Gln Lys Gln Leu Gly Phe Leu Leu Asp Leu Val Cys Arg 930 935 940 His Thr Ala Val Val Leu Gly Leu Asp Thr Ala Ala Glu Val Asp Pro 945 950 955 960 Asp Leu Ser Phe Lys Lys Gln Gly Ile Gln Ser Met Thr Gly Val Glu 965 970 975 Leu Arg Asn Arg Leu Leu Thr Glu Thr Gly Leu Ala Leu Pro Thr Thr 980 985 990 Leu Val Tyr Asp Arg Pro Thr Pro Arg Ala Leu Ala Gln Phe Leu His 995 1000 1005 Thr Glu Leu Leu Asp Gly Ser Pro Ser Gly Ser Val Leu Ala Pro Ala 1010 1015 1020 Gln Lys Ser Phe Glu Ala Gly Gly Pro Gly Val Leu Ser Ser Ala Ala 1025 1030 1035 1040 Val Gly Val Ser Asp Ala Arg Gly Gly Ser Arg Asp Asp Asp Asp Pro 1045 1050 1055 Ile Ala Ile Val Gly Val Gly Cys Arg Leu Pro Gly Gly Val Asp Ser 1060 1065 1070 Arg Ala Ala Leu Trp Glu Leu Leu Glu Ser Gly Ala Asp Ala Ile Ser 1075 1080 1085 Ser Phe Pro Thr Asp Arg Gly Trp Asp Leu Asp Gly Leu Tyr Asp Pro 1090 1095 1100 Glu Pro Gly Thr Pro Gly Lys Thr Tyr Val Arg Glu Gly Gly Phe Leu 1105 1110 1115 1120 His Ser Ala Ala Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg 1125 1130 1135 Glu Ala Thr Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Ala Ser 1140 1145 1150 Trp Glu Ala Leu Glu Asp Ala Gly Val Leu Pro Glu Ser Leu Arg Gly 1155 1160 1165 Gly Asp Ala Gly Val Phe Val Gly Ala Thr Ala Pro Glu Tyr Gly Pro 1170 1175 1180 Arg Leu His Glu Gly Ala Asp Gly Tyr Glu Gly Tyr Leu Leu Thr Gly 1185 1190 1195 1200 Thr Thr Ala Ser Val Ala Ser Gly Arg Ile Ala Tyr Thr Leu Gly Thr 1205 1210 1215 Gly Gly Pro Ala Leu Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val 1220 1225 1230 Ala Leu His Leu Ala Val Gln Ala Leu Arg Arg Gly Glu Cys Gly Leu 1235 1240 1245 Ala Leu Ala Gly Gly Ala Thr Val Met Ser Gly Pro Gly Met Phe Val 1250 1255 1260 Glu Phe Ser Arg Gln Arg Gly Leu Ala Pro Asp Gly Arg Cys Met Pro 1265 1270 1275 1280 Phe Ser Ala Asp Ala Asp Gly Thr Ala Trp Ser Glu Gly Val Ala Val 1285 1290 1295 Leu Ala Leu Glu Arg Leu Ser Asp Ala Arg Arg Ala Gly His Arg Val 1300 1305 1310 Leu Gly Val Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn 1315 1320 1325 Gly Leu Thr Ala Pro Asn Arg Ser Ala Gln Glu Gly Val Ile Arg Ala 1330 1335 1340 Ala Leu Ala Asp Ala Gly Leu Ala Pro Gly Asp Val Asp Ala Val Glu 1345 1350 1355 1360 Ala His Gly Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Ser Ala 1365 1370 1375 Leu Leu Ala Thr Tyr Gly Arg Glu Arg Val Gly Asp Pro Leu Trp Leu 1380 1385 1390 Gly Ser Leu Lys Ser Asn Val Gly His Thr Gln Ala Ala Ala Gly Ala 1395 1400 1405 Ala Gly Val Val Lys Met Leu Leu Ala Leu Glu His Gly Thr Leu Pro 1410 1415 1420 Arg Thr Leu His Ala Asp Arg Pro Ser Thr His Val Asp Trp Ser Ser 1425 1430 1435 1440 Gly Thr Val Ala Leu Leu Ala Glu Ala Arg Arg Trp Pro Arg Arg Ser 1445 1450 1455 Asp Arg Pro Arg Arg Ala Ala Val Ser Ser Phe Gly Ile Ser Gly Thr 1460 1465 1470 Asn Ala His Leu Ile Ile Glu Glu Ala Pro Glu Trp Val Glu Asp Ile 1475 1480 1485 Asp Gly Val Ala Ala Pro Asp Arg Gly Thr Ala Asp Ala Ala Ala Pro 1490 1495 1500 Ser Pro Leu Leu Leu Ser Ala Arg Ser Glu Gly Ala Leu Arg Ala Gln 1505 1510 1515 1520 Ala Val Arg Leu Gly Glu Tyr Val Glu Arg Val Gly Ala Asp Pro Arg 1525 1530 1535 Asp Val Ala Tyr Ser Leu Ala Ser Thr Arg Thr Leu Phe Glu His Arg 1540 1545 1550 Ala Val Val Pro Cys Gly Gly Arg Gly Glu Leu Val Ala Ala Leu Gly 1555 1560 1565 Gly Phe Ala Ala Gly Arg Val Ser Gly Gly Val Arg Ser Gly Arg Ala 1570 1575 1580 Val Pro Gly Gly Val Gly Val Leu Phe Thr Gly Gln Gly Ala Gln Trp 1585 1590 1595 1600 Val Gly Met Gly Arg Gly Leu Tyr Ala Gly Gly Gly Val Phe Ala Glu 1605 1610 1615 Val Leu Asp Glu Val Leu Ser Met Val Gly Glu Val Asp Gly Arg Ser 1620 1625 1630 Leu Arg Asp Val Met Phe Gly Asp Val Asp Val Asp Ala Gly Ala Gly 1635 1640 1645 Ala Asp Ala Gly Ala Gly Ala Gly Ala Gly Val Gly Ser Gly Ser Gly 1650 1655 1660 Ser Val Gly Gly Leu Leu Gly Arg Thr Glu Phe Ala Gln Pro Ala Leu 1665 1670 1675 1680 Phe Ala Leu Glu Val Ala Leu Phe Arg Ala Leu Glu Ala Arg Gly Val 1685 1690 1695 Glu Val Ser Val Val Leu Gly His Ser Val Gly Glu Val Ala Ala Ala 1700 1705 1710 Tyr Val Ala Gly Val Leu Ser Leu Gly Asp Ala Val Arg Leu Val Val 1715 1720 1725 Ala Arg Gly Gly Leu Met Gly Gly Leu Pro Val Gly Gly Gly Met Trp 1730 1735 1740 Ser Val Gly Ala Ser Glu Ser Val Val Arg Gly Val Val Glu Gly Leu 1745 1750 1755 1760 Gly Glu Trp Val Ser Val Ala Ala Val Asn Gly Pro Arg Ser Val Val 1765 1770 1775 Leu Ser Gly Asp Val Gly Val Leu Glu Ser Val Val Ala Ser Leu Met 1780 1785 1790 Gly Asp Gly Val Glu Cys Arg Arg Leu Asp Val Ser His Gly Phe His 1795 1800 1805 Ser Val Leu Met Glu Pro Val Leu Gly Glu Phe Arg Gly Val Val Glu 1810 1815 1820 Ser Leu Glu Phe Gly Arg Val Arg Pro Gly Val Val Val Val Ser Gly 1825 1830 1835 1840 Val Ser Gly Gly Val Val Gly Ser Gly Glu Leu Gly Asp Pro Gly Tyr 1845 1850 1855 Trp Val Arg His Ala Arg Glu Ala Val Arg Phe Ala Asp Gly Val Gly 1860 1865 1870 Val Val Arg Gly Leu Gly Val Gly Thr Leu Val Glu Val Gly Pro His 1875 1880 1885 Gly Val Leu Thr Gly Met Ala Gly Glu Cys Leu Gly Ala Gly Asp Asp 1890 1895 1900 Val Val Val Val Pro Ala Met Arg Arg Gly Arg Ala Glu Arg Glu Val 1905 1910 1915 1920 Phe Glu Ala Ala Leu Ala Thr Val Phe Thr Arg Asp Ala Gly Leu Asp 1925 1930 1935 Ala Thr Ala Leu His Thr Gly Ser Thr Gly Arg Arg Ile Asp Leu Pro 1940 1945 1950 Thr Tyr Pro Phe Gln Arg Asp Arg Tyr Trp Leu Asp Pro Val Arg Thr 1955 1960 1965 Ala Val Thr Gly Val Glu Pro Ala Gly Ser Pro Ala Asp Ala Arg Ala 1970 1975 1980 Thr Glu Arg Gly Arg Ser Thr Thr Ala Gly Ile Arg Tyr Arg Val Ala 1985 1990 1995 2000 Trp Gln Pro Ala Val Val Asp Arg Gly Asn Pro Gly Pro Ala Gly His 2005 2010 2015 Val Leu Leu Leu Ala Pro Asp Glu Asp Thr Ala Asp Ser Gly Leu Ala 2020 2025 2030 Pro Ala Ile Ala Arg Glu Leu Ala Val Arg Gly Ala Glu Val His Thr 2035 2040 2045 Val Ala Val Pro Val Gly Thr Gly Arg Glu Ala Ala Gly Asp Leu Leu 2050 2055 2060 Arg Ala Ala Gly Asp Gly Ala Ala Arg Ser Thr Arg Val Leu Trp Leu 2065 2070 2075 2080 Ala Pro Ala Glu Pro Asp Ala Ala Asp Ala Val Ala Leu Val Gln Ala 2085 2090 2095 Leu Gly Glu Ala Val Pro Glu Ala Pro Leu Trp Ile Thr Thr Arg Glu 2100 2105 2110 Ala Ala Ala Val Arg Pro Asp Glu Thr Pro Ser Val Gly Gly Ala Gln 2115 2120 2125 Leu Trp Gly Leu Gly Gln Val Ala Ala Leu Glu Leu Gly Arg Arg Trp 2130 2135 2140 Gly Gly Leu Ala Asp Leu Pro Gly Ser Ala Ser Pro Ala Val Leu Arg 2145 2150 2155 2160 Thr Phe Val Gly Ala Leu Leu Ala Gly Gly Glu Asn Gln Phe Ala Val 2165 2170 2175 Arg Pro Ser Gly Val His Val Arg Arg Val Val Pro Ala Pro Val Pro 2180 2185 2190 Val Pro Ala Ser Ala Arg Thr Val Thr Thr Ala Pro Ala Thr Ala Val 2195 2200 2205 Gly Glu Asp Ala Arg Asn Asp Thr Ser Asp Val Val Val Pro Asp Asp 2210 2215 2220 Arg Trp Ser Ser Gly Thr Val Leu Ile Thr Gly Gly Thr Gly Ala Leu 2225 2230 2235 2240 Gly Ala Gln Val Ala Arg Arg Leu Ala Arg Ser Gly Ala Ala Arg Leu 2245 2250 2255 Leu Leu Val Gly Arg Arg Gly Ala Ala Gly Pro Gly Val Gly Glu Leu 2260 2265 2270 Val Glu Glu Leu Thr Ala Leu Gly Ser Glu Val Ala Val Glu Ala Cys 2275 2280 2285 Asp Val Ala Asp Arg Asp Ala Leu Ala Ala Leu Leu Ala Gly Leu Pro 2290 2295 2300 Glu Glu Arg Pro Leu Val Ala Val Leu His Ala Ala Gly Val Leu Asp 2305 2310 2315 2320 Asp Gly Val Leu Asp Ser Leu Thr Ser Asp Arg Val Asp Ala Val Leu 2325 2330 2335 Arg Asp Lys Val Thr Ala Ala Arg His Leu Asp Glu Leu Thr Ala Asp 2340 2345 2350 Leu Pro Leu Asp Ala Phe Val Leu Phe Ser Ser Ile Val Gly Val Trp 2355 2360 2365 Gly Asn Gly Gly Gln Ala Val Tyr Ala Ala Ala Asn Ala Ala Leu Asp 2370 2375 2380 Ala Leu Ala Gln Arg Arg Arg Ala Arg Gly Ala Arg Ala Ala Ser Ile 2385 2390 2395 2400 Ala Trp Gly Pro Trp Ala Gly Ala Gly Met Ala Ser Gly Thr Ala Ala 2405 2410 2415 Lys Ser Phe Glu Arg Asp Gly Val Thr Ala Leu Asp Pro Glu Arg Ala 2420 2425 2430 Leu Asp Val Leu Asp Asp Val Val Gly Ala Gly Gly Thr Ser Ala Ala 2435 2440 2445 Gly Thr His Ala Ala Gly Glu Ser Ser Leu Leu Val Ala Asp Val Asp 2450 2455 2460 Trp Glu Thr Phe Val Gly Arg Ser Val Thr Arg Arg Thr Trp Ser Leu 2465 2470 2475 2480 Phe Asp Gly Val Ser Ala Ala Arg Ser Ala Arg Ala Gly His Ala Ala 2485 2490 2495 Asp Asp Arg Ala Ala Leu Thr Pro Gly Thr Arg Pro Gly Asp Gly Ala 2500 2505 2510 Pro Gly Gly Ser Gly Gln Asp Gly Gly Glu Gly Arg Pro Trp Leu Ser 2515 2520 2525 Val Gly Pro Ser Pro Ala Glu Arg Arg Arg Ala Leu Leu Thr Leu Val 2530 2535 2540 Arg Ser Glu Ala Ala Gly Ile Leu Arg His Ala Ser Ala Asp Ala Val 2545 2550 2555 2560 Asp Pro Glu Leu Ala Phe Arg Ser Ala Gly Phe Asp Ser Leu Thr Val 2565 2570 2575 Leu Glu Leu Arg Asn Arg Leu Thr Ala Ala Thr Gly Leu Asn Leu Pro 2580 2585 2590 Asn Thr Leu Leu Phe Asp His Pro Thr Pro Leu Ser Leu Ala Ser His 2595 2600 2605 Leu His Asp Glu Leu Phe Gly Pro Asp Ser Glu Ala Glu Pro Ala Ala 2610 2615 2620 Ala Ala Pro Thr Pro Val Met Ala Asp Glu Arg Glu Pro Ile Ala Ile 2625 2630 2635 2640 Val Gly Met Ala Cys Arg Tyr Pro Gly Gly Val Ala Ser Pro Asp Asp 2645 2650 2655 Leu Trp Asp Leu Val Ala Gly Asp Gly His Thr Leu Ser Pro Phe Pro 2660 2665 2670 Ala Asp Arg Gly Trp Asp Val Glu Gly Leu Tyr Asp Pro Glu Pro Gly 2675 2680 2685 Val Pro Gly Lys Ser Tyr Val Arg Glu Gly Gly Phe Leu Arg Ser Ala 2690 2695 2700 Ala Glu Phe Asp Ala Glu Phe Phe Gly Ile Ser Pro Arg Glu Ala Thr 2705 2710 2715 2720 Ala Met Asp Pro Gln Gln Arg Leu Leu Leu Glu Thr Ser Trp Glu Ala 2725 2730 2735 Leu Glu Arg Ala Gly Ile Val Pro Asp Ser Leu Arg Gly Thr Arg Thr 2740 2745 2750 Gly Val Phe Ser Gly Ile Ser Gln Gln Asp Tyr Ala Thr Gln Leu Gly 2755 2760 2765 Asp Ala Ala Asp Thr Tyr Gly Gly His Val Leu Thr Gly Thr Leu Gly 2770 2775 2780 Ser Val Ile Ser Gly Arg Val Ala Tyr Ala Leu Gly Leu Glu Gly Pro 2785 2790 2795 2800 Ala Leu Thr Val Asp Thr Ala Cys Ser Ser Ser Leu Val Ala Leu His 2805 2810 2815 Leu Ala Val Gln Ser Leu Arg Arg Gly Glu Cys Asp Leu Ala Leu Ala 2820 2825 2830 Gly Gly Val Thr Val Met Ala Thr Pro Thr Val Phe Val Glu Phe Ser 2835 2840 2845 Arg Gln Arg Gly Leu Ala Ala Asp Gly Arg Cys Lys Ala Phe Ala Glu 2850 2855 2860 Gly Ala Asp Gly Thr Ala Trp Ala Glu Gly Val Gly Val Leu Leu Val 2865 2870 2875 2880 Glu Arg Leu Ser Asp Ala Arg Arg Asn Gly His Arg Val Leu Ala Val 2885 2890 2895 Val Arg Gly Ser Ala Val Asn Gln Asp Gly Ala Ser Asn Gly Leu Thr 2900 2905 2910 Ala Pro Ser Gly Pro Ala Gln Gln Arg Val Ile Arg Glu Ala Leu Ala 2915 2920 2925 Asp Ala Gly Leu Val Pro Ala Asp Val Asp Val Val Glu Ala His Gly 2930 2935 2940 Thr Gly Thr Ala Leu Gly Asp Pro Ile Glu Ala Gly Ala Leu Leu Ala 2945 2950 2955 2960 Thr Tyr Gly Arg Glu Arg Val Gly Asp Pro Leu Trp Leu Gly Ser Leu 2965 2970 2975 Lys Ser Asn Ile Gly His Ala Gln Ala Ala Ala Gly Val Gly Gly Val 2980 2985 2990 Ile Lys Val Val Gln Gly Met Arg His Gly Ser Leu Pro Arg Thr Leu 2995 3000 3005 His Val Asp Ala Pro Ser Ser Lys Val Glu Trp Ala Ser Gly Ala Val 3010 3015 3020 Glu Leu Leu Thr Glu Thr Arg Ser Trp Pro Arg Arg Val Glu Arg Val 3025 3030 3035 3040 Arg Arg Ala Ala Val Ser Ala Phe Gly Val Ser Gly Thr Asn Ala His 3045 3050 3055 Val Val Leu Glu Glu Ala Pro Ala Glu Ala Gly Ser Glu His Gly Asp 3060 3065 3070 Gly Pro Glu Pro Glu Arg Pro Asp Ala Val Thr Gly Pro Leu Ser Trp 3075 3080 3085 Val Leu Ser Ala Arg Ser Glu Gly Ala Leu Arg Ala Gln Ala Val Arg 3090 3095 3100 Leu Arg Glu Cys Val Glu Arg Val Gly Ala Asp Pro Arg Asp Val Ala 3105 3110 3115 3120 Gly Ser Leu Val Val Ser Arg Ala Ser Phe Gly Glu Arg Ala Val Val 3125 3130 3135 Val Gly Arg Gly Arg Glu Glu Leu Leu Ala Gly Leu Asp Val Val Ala 3140 3145 3150 Ala Gly Ala Pro Val Gly Val Ser Ser Gly Ala Gly Ala Val Val Arg 3155 3160 3165 Gly Ser Ala Val Arg Gly Arg Gly Val Gly Val Leu Phe Thr Gly Gln 3170 3175 3180 Gly Ala Gln Trp Val Gly Met Gly Arg Gly Leu Tyr Ala Gly Gly Gly 3185 3190 3195 3200 Val Phe Ala Glu Val Leu Asp Glu Val Leu Ser Val Val Gly Glu Val 3205 3210 3215 Asp Gly Arg Ser Leu Arg Asp Val Met Phe Ala Asp Ala Asp Ser Val 3220 3225 3230 Leu Gly Gly Leu Leu Gly Arg Thr Glu Phe Ala Gln Pro Ala Leu Phe 3235 3240 3245 Ala Leu Glu Val Ala Leu Phe Arg Ala Leu Glu Ala Arg Gly Val Glu 3250 3255 3260 Val Ser Val Val Leu Gly His Ser Val Gly Glu Val Ala Ala Ala Tyr 3265 3270 3275 3280 Val Ala Gly Val Leu Ser Leu Gly Asp Ala Val Arg Leu Val Val Ala 3285 3290 3295 Arg Gly Gly Leu Met Gly Gly Leu Pro Val Gly Gly Gly Met Trp Ser 3300 3305 3310 Val Gly Ala Ser Glu Ser Val Val Arg Gly Val Val Glu Gly Leu Gly 3315 3320 3325 Glu Trp Val Ser Val Ala Ala Val Asn Gly Pro Arg Ser Val Val Leu 3330 3335 3340 Ser Gly Asp Val Gly Val Leu Glu Ser Val Val Val Thr Leu Met Gly 3345 3350 3355 3360 Asp Gly Val Glu Cys Arg Arg Leu Asp Val Ser His Gly Phe His Ser 3365 3370 3375 Val Leu Met Glu Pro Val Leu Gly Glu Phe Arg Gly Val Val Glu Ser 3380 3385 3390 Leu Glu Phe Gly Arg Val Arg Pro Gly Val Val Val Val Ser Gly Val 3395 3400 3405 Ser Gly Gly Val Val Gly Ser Gly Glu Leu Gly Asp Pro Gly Tyr Trp 3410 3415 3420 Val Arg His Ala Arg Glu Ala Val Arg Phe Ala Asp Gly Val Gly Val 3425 3430 3435 3440 Val Arg Gly Leu Gly Val Gly Thr Leu Val Glu Val Gly Pro His Gly 3445 3450 3455 Val Leu Thr Gly Met Ala Gly Gln Cys Leu Glu Ala Gly Asp Asp Val 3460 3465 3470 Val Val Val Pro Ala Met Arg Arg Gly Arg Pro Glu Arg Glu Val Phe 3475 3480 3485 Glu Ala Ala Leu Ala Thr Val Phe Thr Arg Asp Ala Gly Leu Asp Ala 3490 3495 3500 Thr Thr Leu His Thr Gly Ser Thr Gly Arg Arg Ile Asp Leu Pro Thr 3505 3510 3515 3520 Tyr Pro Phe Gln His Asn Arg Tyr Trp Ala Thr Gly Ser Val Thr Gly 3525 3530 3535 Ala Thr Gly Thr Ser Ala Ala Ala Arg Phe Gly Leu Glu Trp Lys Asp 3540 3545 3550 His Pro Phe Leu Ser Gly Ala Thr Pro Ile Ala Gly Ser Gly Ala Leu 3555 3560 3565 Leu Leu Thr Gly Arg Val Gly Leu Ala Ala His Pro Trp Leu Ala Asp 3570 3575 3580 His Ala Ile Ser Gly Thr Val Leu Leu Pro Gly Thr Ala Ile Ala Asp 3585 3590 3595 3600 Leu Leu Leu Arg Ala Val Glu Glu Val Gly Ala Gly Gly Val Glu Glu 3605 3610 3615 Leu Thr Leu His Glu Pro Leu Leu Leu Pro Glu Arg Gly Gly Leu His 3620 3625 3630 Val Gln Val Leu Val Glu Ala Ala Asp Glu Gln Gly Arg Arg Ala Val 3635 3640 3645 Ala Val Ala Ala Arg Pro Glu Gly Pro Gly Arg Asp Gly Glu Glu Gln 3650 3655 3660 Glu Trp Thr Arg His Ala Glu Gly Val Leu Thr Ser Thr Glu Thr Ala 3665 3670 3675 3680 Val Pro Asp Met Gly Trp Ala Ala Gly Ala Trp Pro Pro Pro Gly Ala 3685 3690 3695 Glu Pro Ile Asp Val Glu Glu Leu Tyr Asp Ala Phe Ala Ala Asp Gly 3700 3705 3710 Tyr Gly Tyr Gly Pro Ala Phe Thr Ala Leu Ser Gly Val Trp Arg Leu 3715 3720 3725 Gly Asp Glu Leu Phe Ala Glu Val Arg Arg Pro Ala Gly Gly Ala Gly 3730 3735 3740 Thr Thr Gly Asp Gly Phe Gly Val His Pro Ala Leu Phe Asp Ala Ala 3745 3750 3755 3760 Leu His Pro Trp Arg Ala Gly Gly Leu Leu Pro Asp Thr Gly Gly Thr 3765 3770 3775 Thr Trp Ala Pro Phe Ser Trp Gln Gly Ile Ala Leu His Thr Thr Gly 3780 3785 3790 Ala Glu Thr Leu Arg Val Arg Leu Ala Pro Ala Ala Gly Gly Thr Glu 3795 3800 3805 Ser Ala Phe Ser Val Gln Ala Ala Asp Pro Ala Gly Thr Pro Val Leu 3810 3815 3820 Thr Leu Asp Ala Leu Leu Leu Arg Pro Val Thr Leu Gly Arg Ala Asp 3825 3830 3835 3840 Ala Pro Gln Pro Leu Tyr Arg Val Asp Trp Gln Pro Val Gly Gln Gly 3845 3850 3855 Thr Glu Ala Ser Gly Ala Gln Gly Trp Thr Val Leu Gly Gln Ala Ala 3860 3865 3870 Ala Glu Thr Val Ala Gln Pro Ala Ala His Ala Asp Leu Thr Ala Leu 3875 3880 3885 Arg Thr Ala Val Ala Ala Ala Gly Thr Pro Val Pro Arg Leu Val Val 3890 3895 3900 Val Ser Pro Val Asp Thr Arg Leu Asp Glu Gly Pro Val Leu Ala Asp 3905 3910 3915 3920 Ala Glu Ala Arg Ala Arg Ala Gly Asp Gly Trp Asp Asp Asp Pro Leu 3925 3930 3935 Arg Val Ala Leu Gly Arg Gly Leu Thr Leu Val Arg Glu Trp Val Glu 3940 3945 3950 Asp Glu Arg Leu Ala Asp Ser Arg Leu Val Val Leu Thr Arg Gly Ala 3955 3960 3965 Val Ala Ala Gly Pro Gly Asp Val Pro Asp Leu Thr Gly Ala Ala Leu 3970 3975 3980 Trp Gly Leu Leu Arg Ser Ala Gln Ser Glu Tyr Pro Asp Arg Phe Thr 3985 3990 3995 4000 Leu Ile Asp Val Asp Asp Ser Pro Glu Ser Arg Ala Ala Leu Pro Arg 4005 4010 4015 Ala Leu Gly Ser Ala Glu Arg Gln Leu Ala Leu Arg Thr Gly Asp Val 4020 4025 4030 Leu Ala Pro Ala Leu Val Pro Met Ala Thr Arg Pro Ala Glu Thr Thr 4035 4040 4045 Pro Ala Thr Ala Val Ala Ser Ala Thr Thr Gln Thr Gln Val Thr Ala 4050 4055 4060 Pro Ala Pro Asp Asp Pro Ala Ala Asp Ala Val Phe Asp Pro Ala Gly 4065 4070 4075 4080 Thr Val Leu Ile Thr Gly Gly Thr Gly Ala Leu Gly Arg Arg Val Ala 4085 4090 4095 Ser His Leu Ala Arg Arg Tyr Gly Val Arg His Met Leu Leu Val Ser 4100 4105 4110 Arg Arg Gly Pro Asp Ala Pro Glu Ala Gly Pro Leu Glu Arg Glu Leu 4115 4120 4125 Ala Gly Leu Gly Val Thr Ala Thr Phe Leu Ala Cys Asp Leu Thr Asp 4130 4135 4140 Ile Glu Ala Val Arg Lys Ala Val Ala Ala Val Pro Ser Asp His Pro 4145 4150 4155 4160 Leu Thr Gly Val Val His Thr Ala Gly Val Leu Asp Asp Gly Ala Leu 4165 4170 4175 Thr Gly Leu Thr Arg Gln Arg Leu Asp Thr Val Leu Arg Pro Lys Ala 4180 4185 4190 Asp Ala Val Arg Asn Leu His Glu Ala Thr Leu Asp Arg Pro Leu Arg 4195 4200 4205 Ala Phe Val Leu Phe Ser Ala Ala Ala Gly Leu Leu Gly Arg Pro Gly 4210 4215 4220 Gln Ala Ser Tyr Ala Ala Ala Asn Ala Val Leu Asp Ala Leu Ala Gly 4225 4230 4235 4240 Ala Arg Arg Ala Ala Gly Leu Pro Ala Val Ser Leu Ala Trp Gly Leu 4245 4250 4255 Trp Asp Glu Gln Thr Gly Met Ala Gly Gly Leu Asp Glu Met Ala Leu 4260 4265 4270 Arg Val Leu Arg Arg Asp Gly Ile Ala Ala Met Pro Pro Glu Gln Gly 4275 4280 4285 Leu Glu Leu Leu Asp Leu Ala Leu Thr Gly His Arg Asp Gly Pro Ala 4290 4295 4300 Val Leu Val Pro Leu Leu Leu Asp Gly Ala Ala Leu Arg Arg Thr Ala 4305 4310 4315 4320 Lys Glu Arg Gly Ala Ala Thr Met Ser Pro Leu Leu Arg Ala Leu Leu 4325 4330 4335 Pro Ala Ala Leu Arg Arg Ser Gly Gly Ala Gly Ala Pro Ala Ala Ala 4340 4345 4350 Asp Arg His Gly Lys Glu Ala Asp Pro Gly Ala Gly Arg Leu Ala Gly 4355 4360 4365 Met Val Ala Leu Glu Ala Ala Glu Arg Ser Ala Ala Val Leu Glu Leu 4370 4375 4380 Val Thr Glu Gln Val Ala Glu Val Leu Gly Tyr Ala Ser Ala Ala Glu 4385 4390 4395 4400 Ile Glu Pro Glu Arg Pro Phe Arg Glu Ile Gly Val Asp Ser Leu Ala 4405 4410 4415 Ala Val Glu Leu Arg Asn Arg Leu Ser Arg Leu Val Gly Leu Arg Leu 4420 4425 4430 Pro Thr Thr Leu Ser Phe Asp His Pro Thr Pro Lys Asp Met Ala Gln 4435 4440 4445 His Ile Asp Gly Gln Leu Pro Arg Pro Ala Gly Ala Ser Pro Ala Asp 4450 4455 4460 Ala Ala Leu Glu Gly Ile Gly Asp Leu Ala Arg Ala Val Ala Leu Leu 4465 4470 4475 4480 Gly Thr Gly Asp Ala Arg Arg Ala Glu Val Arg Glu Gln Leu Val Gly 4485 4490 4495 Leu Leu Ala Ala Leu Asp Pro Pro Gly Arg Thr Gly Thr Ala Ala Pro 4500 4505 4510 Gly Val Pro Ser Gly Ala Asp Gly Ala Glu Pro Thr Val Thr Asp Arg 4515 4520 4525 Leu Asp Glu Ala Thr Asp Asp Glu Ile Phe Ala Phe Leu Asp Glu Gln 4530 4535 4540 Leu * 4545

【００４９】配列番号：１５配列の長さ：１５塩基対配列の型：核酸鎖の数: 一本鎖トポロリー：直鎖状配列の種類：ＤＮＡ（genomic）配列 CGAGGCCGGC GGGCC

【図面の簡単な説明】

【図１】 Streptomyces fradiae ＤＮＡ（〜４５ｋ
ｂ）のチラクトンポリケチドシンターゼ領域（ｔｙｌ
Ｇ）のマップである。

【図２】チラクトン合成の生合成経路である。

【図３】ｔｙｌＧＤＮＡの全領域に及ぶ２つのクロ
ーンのマップである。

【図４】 Streptomyces ambofaciens ＤＮＡのｓｒｍ
Ｇ領域のマップである。ｋｂで示される距離はｓｒｍＧ
の開始部からの距離である。

【図５】プラテノリド合成の生合成経路である。

【図６】ｓｒｍＳＤＮＡの全領域に及ぶ２つのクロ
ーンのマップである。

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.⁶ 識別記号庁内整理番号ＦＩ技術表示箇所Ｃ１２Ｒ 1:465） (72)発明者スチュアート・アレン・クストスアメリカ合衆国46256インディアナ州インディアナポリス、ナラガンセット・コート 8206番 (72)発明者ポール・ロバート・ロステック・ジュニアアメリカ合衆国46237インディアナ州インディアナポリス、サフロン・ドライブ4247 番 (72)発明者キンバリー・リン・サットンアメリカ合衆国46163インディアナ州ニュー・パレスタイン、サウス・ファロー・トレイル3581番

Claims

【特許請求の範囲】

【請求項１】チラクトンシンターゼドメインをコード
する単離されたＤＮＡ配列を含むＤＮＡ分子。
【請求項２】単離されたＤＮＡ配列が配列番号１中
のヌクレオチド９４２−２１５６、２５７１−３５５
７、３６７５−３９２９、３９９３−５２６４、５６３
１−６６１７、７４１０−７９４９、８２２０−８４７
１、８５４１−９８１２、１０２６０−１１２４６、１
１３１９−１１８７６、１２８６１−１３４１５、１３
７１９−１３９７０、１４４１１−１５６９７、１６０
５５−１７１２２、１７１９８−１７７９４、１８５８
４−１９１３８、１９４１５−１９６６６、２０１３６
−２１４０４、２１７７１−２２７５７、２３５４１−
２４０７７、２４３６０−２４６１１、２４６７５−２
５９４９、２６２９２−２７２８４、２７３６０−２７
９１７、２８７６７−２９８１３、２９８２９−３０３
６８、３０６５１−３０９０２、３１３３７−３２６０
８、３２９７５−３３９６１、３４６９４−３５２３
６、３５４９２−３５７４３、３６３６０−３７６３
１、３７９８９−３８９８７、３９７５９−４０３１
３、４０５７５−４０８２６、および４１２３５−４１
３３３からなる群から選ばれるものである請求項１に記
載のＤＮＡ分子。
【請求項３】単離されたＤＮＡ配列が配列番号１で示
されるものである請求項１に記載のＤＮＡ分子。
【請求項４】チラクトンシンターゼドメインからなる
アミノ酸配列を含むポリペプチド。
【請求項５】該アミノ酸配列が、（ａ）配列番号２中
のアミノ酸４３−４４７、５８６−９１４、９５４−１
０３８、１０６０−１４８３、１６０６−１９３４、２
１９９−２３７８、２４６９−２５５２、２５７６−２
９９９、３１４９−３４７７、３５０２−３６８７、４
０１６−４２００、および４３０２−４３８５、（ｂ）
配列番号３中のアミノ酸２１−４４９、５６９−９２
４、９５０−１１４８、１４１２−１５９６、および１
６８９−１７７２、（ｃ）配列番号４中の４３−４６
５、５８８−９１６、１１７８−１３５６、１４５１−
１５３４、１５５６−１９８０、２０９５−２４２５、
２４５１−２６３６、３２７４−３４５３、および３５
４８−３６３１、（ｄ）配列番号５中のアミノ酸３６−
４５９、５８２−９１０、１１５５−１３３５、および
１４２１−１５０４、および（ｅ）配列番号６中のアミ
ノ酸３８−４６１、５８１−９１３、１１７１−１３５
５、１４４３−１５２６、および１６６３−１６９５か
らなる群から選ばれるものである請求項４に記載のポリ
ペプチド。
【請求項６】該アミノ酸配列が配列番号２、３、４、
５、および６から選ばれるものである請求項４に記載の
ポリペプチド。
【請求項７】請求項１に記載のＤＮＡ分子を含む組換
えＤＮＡベクター。
【請求項８】請求項７に記載の組換えＤＮＡベクター
で形質転換された宿主細胞。
【請求項９】単離されたＤＮＡ配列が配列番号１３で
示されるものである請求項１に記載のＤＮＡ分子。
【請求項１０】配列番号１４で示されるポリペプチ
ド。