JPH09502987A - 殺菌性／浸透性が向上した（ｂｐｉ）タンパク質生成物および抗生物質の投与によるグラム陰性細菌感染の治療方法 - Google Patents

殺菌性／浸透性が向上した（ｂｐｉ）タンパク質生成物および抗生物質の投与によるグラム陰性細菌感染の治療方法

Info

Publication number: JPH09502987A
Authority: JP; Japan
Prior art keywords: gram; antibiotic; antibiotics; drug; negative bacterial
Prior art date: 1993-09-22
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP7509977A

Other languages

English (en)

Japanese (ja)

Inventor

コーエン，ジョナサン

クン，アダ，エイチ．，シー．

ランバート，ルイス，エイチ．，ジュニア

セカンドリトル，ロジャー，ジー．，ザ

Original Assignee

ゾーマコーポレイション

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-22

Filing date

1994-09-22

Publication date

1997-03-25

1994-09-22 Application filed by ゾーマコーポレイション filed Critical ゾーマコーポレイション

1997-03-25 Publication of JPH09502987A publication Critical patent/JPH09502987A/ja

Status Expired - Lifetime legal-status Critical Current

Links

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239000000814 tuberculostatic agent Substances 0.000 description 1
210000004881 tumor cell Anatomy 0.000 description 1
201000008297 typhoid fever Diseases 0.000 description 1
210000000689 upper leg Anatomy 0.000 description 1
210000002700 urine Anatomy 0.000 description 1
238000002255 vaccination Methods 0.000 description 1
125000002987 valine group Chemical group [H]N([H])C([H])(C(*)=O)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
238000009834 vaporization Methods 0.000 description 1
230000008016 vaporization Effects 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000035899 viability Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1
BPICBUSOMSTKRF-UHFFFAOYSA-N xylazine Chemical compound CC1=CC=CC(C)=C1NC1=NCCCS1 BPICBUSOMSTKRF-UHFFFAOYSA-N 0.000 description 1
229960001600 xylazine Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4742—Bactericidal/Permeability-increasing protein [BPI]
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Immunology (AREA)
Engineering & Computer Science (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Marine Sciences & Fisheries (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Cash Registers Or Receiving Machines (AREA)
Management, Administration, Business Operations System, And Electronic Commerce (AREA)

JP7509977A 1993-09-22 1994-09-22 殺菌性／浸透性が向上した（ｂｐｉ）タンパク質生成物および抗生物質の投与によるグラム陰性細菌感染の治療方法 Expired - Lifetime JPH09502987A (ja)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US12565193A	1993-09-22	1993-09-22
US08/125,651		1993-09-22
US27340194A	1994-07-11	1994-07-11
US08/273,401		1994-07-11
PCT/US1994/011225 WO1995008344A1 (fr)	1993-09-22	1994-09-22	Procede de traitement d'infections bacteriennes gram negatif par administration d'un produit proteique bactericide/augmentant la permeabilite (bpi) et d'un antibiotique

Publications (1)

Publication Number	Publication Date
JPH09502987A true JPH09502987A (ja)	1997-03-25

Family

ID=26823793

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP7509977A Expired - Lifetime JPH09502987A (ja)	1993-09-22	1994-09-22	殺菌性／浸透性が向上した（ｂｐｉ）タンパク質生成物および抗生物質の投与によるグラム陰性細菌感染の治療方法

Country Status (12)

Country	Link
US (2)	US5523288A (fr)
EP (1)	EP0759774B1 (fr)
JP (1)	JPH09502987A (fr)
AT (1)	ATE218880T1 (fr)
AU (1)	AU695814B2 (fr)
CA (1)	CA2172245C (fr)
DE (1)	DE69430823T2 (fr)
DK (1)	DK0759774T3 (fr)
ES (1)	ES2178656T3 (fr)
NZ (1)	NZ275205A (fr)
PT (1)	PT759774E (fr)
WO (1)	WO1995008344A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5652332A (en) *	1993-03-12	1997-07-29	Xoma	Biologically active peptides from functional domains of bactericidal/permeability-increasing protein and uses thereof
PT759774E (pt) *	1993-09-22	2002-11-29	Xoma Technology Ltd	Metodo para o tratamento de infeccoes bacterianas gram-negativas por administracao de um produto de proteina bactericida indutora da permeabilidade (bip) e de um antibiotico
US5447913A (en) *	1994-03-11	1995-09-05	Xoma Corporation	Therapeutic uses of bactericidal/permeability-increasing protein dimer products
WO1997004008A1 (fr) *	1995-07-20	1997-02-06	Xoma Corporation	Peptides antifongiques
AUPN771596A0 (en) *	1996-01-25	1996-02-15	Mclean, Allan Joseph	Methods of and compositions for potentiating the action of agents active on cell-wall sites of susceptible bacteria
DE69703689T2 (de)	1996-05-10	2001-05-10	Xoma Technology Ltd., Berkeley	Therapeutische anwendungen von bpi-protein-produkten zur behandlung von humaner meningococcämia
US5741779A (en) *	1996-05-10	1998-04-21	Xoma Corporation	Antithrombotic materials and methods
NZ332954A (en) *	1996-05-23	2000-07-28	Xoma Corp	Use of BPI protein products to treat humans with hemorrhage due to trauma
US5888973A (en)	1996-08-09	1999-03-30	Xoma Corporation	Anti-chlamydial uses of BPI protein products
US6180604B1 (en) *	1996-08-21	2001-01-30	Micrologix Biotech Inc.	Compositions and methods for treating infections using analogues of indolicidin
US6503881B2 (en) *	1996-08-21	2003-01-07	Micrologix Biotech Inc.	Compositions and methods for treating infections using cationic peptides alone or in combination with antibiotics
US6482796B2 (en) *	1996-11-01	2002-11-19	Xoma Corporation	Therapeutic uses of N-terminal BPI protein products in ANCA-positive patients
US6406880B1 (en)	1997-05-02	2002-06-18	Integrated Research Technology, Llc	Betaines as adjuvants to susceptibility testing and antimicrobial therapy
CA2288457A1 (fr) *	1997-05-02	1998-11-12	Integrated Research Technology, Llc	Utilisation de betaines comme adjuvants d'essais de sensibilite et d'une therapie anti-microbienne
US7067500B2 (en) *	1997-05-02	2006-06-27	Integrated Research Technology, Llc	Betaines as adjuvants to susceptibility testing and antimicrobial therapy
US6093573A (en) *	1997-06-20	2000-07-25	Xoma	Three-dimensional structure of bactericidal/permeability-increasing protein (BPI)
AU3642199A (en) *	1998-04-14	1999-11-01	Ribogene, Inc.	Assays for inhibitors of bacterial translation initiation factor
US6013631A (en) *	1998-06-19	2000-01-11	Xoma Corporation	Bactericidal/permeability-increasing protein (BPI) deletion analogs
US5977091A (en) *	1998-09-21	1999-11-02	The Research Foundation Of State University Of New York	Method of preventing acute lung injury
US6790661B1 (en) *	1999-07-16	2004-09-14	Verax Biomedical, Inc.	System for detecting bacteria in blood, blood products, and fluids of tissues
US6696239B1 (en) *	2000-04-20	2004-02-24	Biolog, Inc.	Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
US20020173464A1 (en) *	2000-12-01	2002-11-21	King George L.	Modulation of pericyte proliferation
DE60131015T2 (de)	2000-12-15	2008-07-10	Vertex Pharmaceuticals Inc., Cambridge	Bakterielle gyrase-hemmer und deren verwendung
US6835536B2 (en)	2001-08-21	2004-12-28	Micrologix Biotech Inc.	Antimicrobial cationic peptides and formulations thereof
AU2002328203C1 (en)	2001-08-24	2009-01-08	Migenix Inc.	Antimicrobial and anti-inflammatory peptides
US20030232401A1 (en) *	2002-06-12	2003-12-18	Pugia Michael J.	Bacterial test method by glycated label binding
US20040037895A1 (en) *	2002-08-23	2004-02-26	Alex Zhu	Methods of treating involuntary facial spasms and facial wrinkles
US7655646B2 (en) *	2003-01-21	2010-02-02	Thallion Pharmaceuticals, Inc.	Dibenzodiazepinone analogues, processes for their production and their use as pharmaceuticals
AU2004206046B2 (en) *	2003-01-21	2009-12-17	Thallion Pharmaceuticals Inc.	Farnesyl dibenzodiazepinones, processes for their production and their use as pharmaceuticals
CA2484638C (fr) *	2003-09-11	2008-03-25	Ecopia Biosciences Inc.	Polycetides polyeniques et methodes de production connexes
WO2006047891A1 (fr) *	2004-11-08	2006-05-11	Ecopia Biosciences Inc.	Composes aromatiques polycycliques et derives de ces derniers, ainsi que procedes pour leur preparation
EP1741440A1 (fr) *	2005-07-08	2007-01-10	Mellitus S.L.	Utilisation de la protéine BPI pour le traitement de troubles du métabolisme et de maladies cardiovasculaires
US20080114054A1 (en) *	2006-11-14	2008-05-15	Rath Microbes	Compositions and methods for reducing antimicrobial resistance of microbes
EP2601194B1 (fr)	2010-08-03	2016-05-25	Merck Sharp & Dohme Corp.	Composés d'imidazoyle fusionné utiles en tant qu'agents antimicrobiens
RU2609259C2 (ru) *	2011-01-14	2017-01-31	Сперо Тринем, Инк.	Пиримидиновые ингибиторы гиразы и топоизомеразы iv
WO2012112438A2 (fr) *	2011-02-16	2012-08-23	The Penn State Research Foundation	Compositions et agents antimicrobiens, et leurs méthodes de production et d'utilisation
CN103702994B (zh)	2011-06-20	2016-03-23	沃泰克斯药物股份有限公司	旋转酶和拓扑异构酶抑制剂的磷酸酯
US9018216B2 (en)	2012-07-18	2015-04-28	Vertex Pharmaceuticals Incorporated	Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
WO2014026143A1 (fr) *	2012-08-09	2014-02-13	Pono Corporation	Composés antimicrobiens conjugués et composés anticancéreux conjugués et leurs utilisations
WO2014160814A1 (fr) *	2013-03-26	2014-10-02	Rutgers, The State University Of New Jersey	Destruction bactérienne synthétique et améliorée mettant en jeu la bicyclomycine
JP2018529689A (ja) *	2015-09-17	2018-10-11	ソウル大学校産学協力団ＳｅｏｕｌＮａｔｉｏｎａｌＵｎｉｖｅｒｓｉｔｙＲ＆ＤｂＦｏｕｎｄａｔｉｏｎ	グラム陰性菌に対する抗菌活性を示す切断または折り畳まれたヘリックスペプチドまたはペプチド類似体およびその用途
US11185555B2 (en)	2016-04-11	2021-11-30	Noah James Harrison	Method to kill pathogenic microbes in a patient
US20210023101A1 (en) *	2017-07-19	2021-01-28	The University Of North Carolina At Chapel Hill	Potentiation of antibiotic effect

Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5028251A (fr) *	1973-07-12	1975-03-22
JPS55134471A (en) *	1979-04-04	1980-10-20	Toshiba Corp	Sales management system in small-scale computer constitution
JPS60128596A (ja) *	1983-12-15	1985-07-09	東芝テック株式会社	電子キヤツシユレジスタ
JPS619790A (ja) *	1984-06-25	1986-01-17	オムロン株式会社	電子式キヤツシユレジスタ

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1237671A (fr) *	1983-08-01	1988-06-07	Michael W. Fountain	Augmentation de l'activite pharmaceutique
US4863727A (en) *	1986-04-09	1989-09-05	Cetus Corporation	Combination therapy using interleukin-2 and tumor necrosis factor
US5198541A (en) *	1987-08-11	1993-03-30	New York University	Dna encoding bactericidal/permeability-increasing proteins
EP0652230B1 (fr) *	1987-08-11	2005-12-14	New York University	Fragments biologiquement actifs de protéine bactéricide/accroisant la perméabilité
ATE207205T1 (de) *	1988-06-23	2001-11-15	Ass Cape Cod Inc	Verfahren zumm assay von endotoxin-konzentration
US5234912A (en) *	1989-02-14	1993-08-10	Incyte Pharmaceuticals, Inc.	Pharmaceutical compositions comprising recombinant BPI proteins and a lipid carrier and uses thereof
US5308834A (en) *	1989-02-14	1994-05-03	Incyte Pharmaceuticals, Inc.	Treatment of endotoxin-associated shock and prevention thereof using a BPI protein
US5334584A (en) *	1989-02-14	1994-08-02	Incyte Pharamaceuticals, Inc.	Recombinant, non-glycosylated bpi protein and uses thereof
US5171739A (en) *	1989-02-14	1992-12-15	Incyte Pharmaceuticals, Inc.	Treatment of endotoxin-associated shock and preventation thereof using a BPI protein
US5089274A (en) *	1989-02-14	1992-02-18	Incyte Pharmaceuticals, Inc.	Use of bactericidal/permeability increasing protein or biologically active analogs thereof to treat endotoxin-related disorders
EP0563222B1 (fr) *	1990-12-03	1998-02-25	New York University	Fragments biologiquement actifs de proteines bactericides/accroissant la permeabilite
US5156665A (en) *	1991-01-03	1992-10-20	Rohm And Haas Company	Antimicrobial compositions comprising iodopropargyl compounds and isothiazolones and methods of controlling microbes
WO1993006228A1 (fr) *	1991-09-26	1993-04-01	Incyte Pharmaceuticals, Inc.	Nouvelle forme de proteine fixatrice des liposaccharides
US5643570A (en) *	1992-05-19	1997-07-01	Xoma Corporation	BPI-immunoglobulin fusion proteins
AU669723B2 (en) *	1992-05-19	1996-06-20	Xoma Corporation	Improved methods for the preparation of endotoxin-binding proteins
JP3946246B2 (ja) *	1993-02-02	2007-07-18	ゾーマ・コーポレイション	殺菌性／浸透性増大タンパク質（Ｂａｃｔｅｒｉｃｉｄａｌ／ＰｅｒｍｅａｂｉｌｉｔｙＩｎｃｒｅａｓｉｎｇｐｒｏｔｅｉｎ：ＢＰＩ）及び界面活性剤を含有する医薬組成物
US5420019A (en) *	1993-02-02	1995-05-30	Xoma Corporation	Stable bactericidal/permeability-increasing protein muteins
ES2123134T3 (es) *	1993-03-12	1999-01-01	Xoma Corp	Peptidos biologicamente activos de dominios funcionales de la proteina bactericida aumentadora de la permeabilidad y usos de los mismos.
CA2157925C (fr) *	1993-03-12	2000-06-06	Xoma Corporation	Traitement de maladies mycobacteriennes par administration de produits proteiniques bactericides augmentant la permeabilite
US5348942A (en) *	1993-03-12	1994-09-20	Xoma Corporation	Therapeutic uses of bactericidal/permeability increasing protein products
JPH08509703A (ja) *	1993-03-12	1996-10-15	ゾーマコーポレイション	殺菌／透過性増加タンパク質産物の治療用途
PT759774E (pt) *	1993-09-22	2002-11-29	Xoma Technology Ltd	Metodo para o tratamento de infeccoes bacterianas gram-negativas por administracao de um produto de proteina bactericida indutora da permeabilidade (bip) e de um antibiotico

1994
- 1994-09-22 PT PT94931793T patent/PT759774E/pt unknown
- 1994-09-22 WO PCT/US1994/011225 patent/WO1995008344A1/fr not_active Ceased
- 1994-09-22 ES ES94931793T patent/ES2178656T3/es not_active Expired - Lifetime
- 1994-09-22 JP JP7509977A patent/JPH09502987A/ja not_active Expired - Lifetime
- 1994-09-22 AT AT94931793T patent/ATE218880T1/de not_active IP Right Cessation
- 1994-09-22 AU AU80740/94A patent/AU695814B2/en not_active Ceased
- 1994-09-22 DE DE69430823T patent/DE69430823T2/de not_active Expired - Fee Related
- 1994-09-22 US US08/311,611 patent/US5523288A/en not_active Expired - Lifetime
- 1994-09-22 NZ NZ275205A patent/NZ275205A/en not_active IP Right Cessation
- 1994-09-22 CA CA002172245A patent/CA2172245C/fr not_active Expired - Fee Related
- 1994-09-22 DK DK94931793T patent/DK0759774T3/da active
- 1994-09-22 EP EP94931793A patent/EP0759774B1/fr not_active Expired - Lifetime
1996
- 1996-06-03 US US08/657,162 patent/US6140306A/en not_active Expired - Fee Related

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS5028251A (fr) *	1973-07-12	1975-03-22
JPS55134471A (en) *	1979-04-04	1980-10-20	Toshiba Corp	Sales management system in small-scale computer constitution
JPS60128596A (ja) *	1983-12-15	1985-07-09	東芝テック株式会社	電子キヤツシユレジスタ
JPS619790A (ja) *	1984-06-25	1986-01-17	オムロン株式会社	電子式キヤツシユレジスタ

Also Published As

Publication number	Publication date
US5523288A (en)	1996-06-04
CA2172245A1 (fr)	1995-03-30
ATE218880T1 (de)	2002-06-15
AU8074094A (en)	1995-04-10
DE69430823T2 (de)	2003-02-20
EP0759774B1 (fr)	2002-06-12
WO1995008344A1 (fr)	1995-03-30
ES2178656T3 (es)	2003-01-01
DK0759774T3 (da)	2002-10-07
NZ275205A (en)	1998-03-25
US6140306A (en)	2000-10-31
HK1014155A1 (en)	1999-09-24
CA2172245C (fr)	2003-04-08
PT759774E (pt)	2002-11-29
EP0759774A1 (fr)	1997-03-05
DE69430823D1 (de)	2002-07-18
AU695814B2 (en)	1998-08-20

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Publication	Publication Date	Title
JPH09502987A (ja)	1997-03-25	殺菌性／浸透性が向上した（ｂｐｉ）タンパク質生成物および抗生物質の投与によるグラム陰性細菌感染の治療方法
EP0754050B1 (fr)	2002-06-26	Procede et matieres de traitment d'infections bacteriennes a gram positif
WO1995008344A9 (fr)	1996-10-03	Procede de traitement d'infections bacteriennes gram negatif par administration d'un produit proteique bactericide/augmentant la permeabilite (bpi) et d'un antibiotique
Prins et al.	1995	Antibiotic-induced endotoxin release in patients with gram-negative urosepsis: a double-blind study comparing imipenem and ceftazidime
US5409898A (en)	1995-04-25	Compositions and methods for treating infections caused by organisms sensitive to β-lactam antibiotics
Wade et al.	1981	Piperacillin or ticarcillin plus amikacin: a double-blind prospective comparison of empiric antibiotic therapy for febrile granulocytopenic cancer patients
Wilson et al.	1998	Lung infections. 3. Pseudomonas aeruginosa and other related species.
JP2006321816A (ja)	2006-11-30	殺菌性／透過性増強タンパク質（ｂｐｉ）タンパク質産物を含む、改良された治療用組成物
Ariza et al.	1991	Aztreonam vs. cefotaxime in the treatment of gram-negative spontaneous peritonitis in cirrhotic patients
Goa et al.	2003	Panipenem/betamipron
JPWO2010147145A1 (ja)	2012-12-06	抗グラム陰性菌剤
CN110124012B (zh)	2023-06-16	一种颗粒溶素作为多粘菌素类抗生素增效剂的应用
Wilcox et al.	1985	Laboratory studies on coagulase-negative staphylococci from CAPD-associated peritonitis
Castro	1986	A comparative study of cefadroxil and co-trimoxazole in patients with lower respiratory tract infections
JP3665850B2 (ja)	2005-06-29	免疫賦活剤
Warren	1976	Cyclacillin: microbiological and pharmacological properties and use in chemotherapy of infection-a critical appraisal.
CN112513258A (zh)	2021-03-16	卤素过氧化物酶组合物及其用途
Andersen et al.	1980	Pivmecillinam in the treatment of therapy resistant urinary tract infections: A comparison with pivmecillinam, pivampicillin and their combination
CN111569079B (zh)	2022-08-26	一种抗葡萄球菌感染的抗体抗生素联合制剂
NZ329583A (en)	2001-04-27	Use of a BPI protein and an antibiotic to treat bacterial infections
HK1014155B (en)	2003-04-17	Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (bpi) protein product and antibiotic
HK1014160B (en)	2003-05-09	Anti-gram-positive bacterial methods and materials
Reynaert et al.	1980	Clinical evaluation of cefadroxil: a multicenter trial. II. Urinary tract infections