JPH10501818A - 鋳型指向性環化 - Google Patents

鋳型指向性環化

Info

Publication number
JPH10501818A
JPH10501818A JP8502481A JP50248196A JPH10501818A JP H10501818 A JPH10501818 A JP H10501818A JP 8502481 A JP8502481 A JP 8502481A JP 50248196 A JP50248196 A JP 50248196A JP H10501818 A JPH10501818 A JP H10501818A
Authority
JP
Japan
Prior art keywords
peptide
formula
linker
group
resin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8502481A
Other languages
English (en)
Japanese (ja)
Inventor
ムーア，マイケル・リー
ニューランダー，ケネス・アレン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of JPH10501818A publication Critical patent/JPH10501818A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)
JP8502481A 1994-06-16 1995-06-16 鋳型指向性環化 Pending JPH10501818A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US26093394A 1994-06-16 1994-06-16
US08/260,933 1994-06-16
PCT/US1995/007620 WO1995034577A1 (en) 1994-06-16 1995-06-16 Template directed cyclization

Publications (1)

Publication Number Publication Date
JPH10501818A true JPH10501818A (ja) 1998-02-17

Family

ID=22991260

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8502481A Pending JPH10501818A (ja) 1994-06-16 1995-06-16 鋳型指向性環化

Country Status (3)

Country Link
EP (1) EP0765341A4 (de)
JP (1) JPH10501818A (de)
WO (1) WO1995034577A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6008321A (en) * 1998-03-16 1999-12-28 Pharmacopeia, Inc. Universal linker for combinatorial synthesis
AU2002346915A1 (en) * 2001-10-15 2003-04-28 Therascope Ag A method of forming a dynamic combinatorial library using a scaffold
FR2868067B1 (fr) * 2004-03-23 2006-06-23 Neomps Sa Derives d'amino-acides utiles comme agents de liaison a un support solide, leur procede de preparation et leur application a lasynthese de peptides

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0175266B1 (de) * 1984-09-12 1996-03-20 Rhone-Poulenc Rorer Pharmaceuticals Inc. Antihypertensive Derivate
JPH0745517B2 (ja) * 1989-11-08 1995-05-17 ダイセル化学工業株式会社 ペプチド、および環状ペプチドの製造方法
EP0788370A4 (de) * 1993-07-09 1998-07-08 Smithkline Beecham Corp Zyklische, teilzufallige peptidbibliotheken

Also Published As

Publication number Publication date
EP0765341A4 (de) 1998-09-16
EP0765341A1 (de) 1997-04-02
WO1995034577A1 (en) 1995-12-21

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