JPH1067620A - Hair grower - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair grower excellent in depilation-preventive effect and hair growing effect, containing a combination of specific plant extract(s) with an amine oxide. SOLUTION: This hair grower contains 0.005-20wt.%, on a dry basis, of extract(s) from Paeonia lactiflora Pallas (Paeonia albiflora Pallas var. irichocarpa Bunge) and/or Paeonia suffruticosa Andrews (Paeonia mountan Sims) (Paeoniaceae) and 0.0001-20wt.% of an amine oxide of the formula (R<1> is a 2-24C alkyl; R<2> is methyl or hydroxyethyl; A is monoxyethylene; (n) is 0-5) (e.g. N,N-dihydroxymethyl-2-dodecylamine oxide). The former extract is obtained from the root of the corresponding plant, while the latter extract from the root bark of the corresponding plant. The extractant to be used is an organic solvent. This hair grower is effective for treating/preventing depilation, being administered through direct coating or spraying on the skin; its daily dose is 0.01-100mg/kg for adult in one to four portions per day.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention belongs to the technical field related to hair restoration. More specifically, it belongs to the technical field related to a hair restorer having an excellent hair loss-preventing effect and a hair-growth effect such as a hair-growth effect, and the hair restorer of the present invention is used particularly in the fields of pharmaceuticals, quasi-drugs, and cosmetics.

[0002]

2. Description of the Related Art Hair restoration is a product that promotes or stimulates the growth of hair, and in today's aging society, the demand for hair growth is increasing year by year as social stress increases. In general, the causes of head baldness and hair loss include the activation of androgens in organs such as hair roots and sebaceous glands, decreased blood flow to hair follicles, excessive secretion of sebum, and the production of peroxides in the scalp. Various causes such as abnormalities, malnutrition, and stress are considered. Conventional hair restorations generally contain a substance having an action of removing or reducing factors considered to be the cause of baldness and hair loss. For example, vitamins such as vitamin B and vitamin E, amino acids such as serine and methionine, vasodilators such as assembly extract and acetylcholine derivatives, anti-inflammatory agents such as purple root extract and hinokitiol, female hormones such as estradiol, cepharanthin and the like Are used in the prevention and treatment of baldness and hair loss.

[0003]

However, in spite of many attempts as described above, the hair-growing effects such as the hair-growth-preventing effect and the hair-growth effect of the conventional hair-growing agent are not always sufficient. Was. The reason for this is that, as described above, the causes of baldness and hair loss are extremely diverse, and the mechanism of hair growth itself is also very complicated, so it is not enough to use a hair restoration that focuses only on those causes and one aspect of the mechanism. It is mentioned.

[0004]

Means for Solving the Problems In order to solve this problem, the present inventor has made intensive studies to provide a new hair restorer having an excellent hair loss preventing effect and a hair growth effect. As a result, the present inventors have found that a hair restorer prepared by combining a specific plant extract and a specific amine oxide has an excellent hair restorer effect, and completed the present invention.

That is, the present invention provides a hair restorer comprising the following components: Peony extract and / or peanut extract One or two amine oxides represented by the following formula (I)
More than species:

Embedded image (Wherein, R ¹ is a linear or branched alkyl group having 2 to 24 carbon atoms, R ² is a methyl group or a hydroxyethyl group, A is a monooxyethylene group, and n is 0 or more and 5 or less. Represents a number).

[0006]

Embodiments of the present invention will be described below. A. The hair restorer of the present invention comprises a peony extract and / or a peanut extract.

[0007] The peony extract used in the present invention is a peony [Paeonia lactiflora Pallas (Paeoni)
trichocarpa Bunge)] and the root extract of this closely related plant. In addition, the peanut extract is also a button family button [Paeonia suffruticosa Andre
ws (Paeonia mountan Sims) (Paeoniaceae)] and the root bark extract of this closely related plant. As a method for extracting these extracts from the above-mentioned raw materials, generally known methods can be used. For example, the above-mentioned raw materials are prepared from hot water, lower alcohols such as methanol and ethanol or hydrates of these lower alcohols or propylene glycol;
It can be obtained by solvent extraction with a solvent such as a polyhydric alcohol such as 1,3-butylene glycol or a hydrate of these polyhydric alcohols. Each of these plant extracts can be independently incorporated into the hair restoration of the present invention, or both can be incorporated in combination.

The amount of these plant extracts in the hair growth composition of the present invention should be appropriately changed according to the specific combination of the plant extract to be blended and the specific mode of the hair growth composition of the present invention. Although not to be limited, in general, in the total amount of hair restoration, as the dry weight of the plant extract,
0.005% by weight or more and 20% by weight or less are preferable,
Particularly preferably, the content is 0.01% by weight or more and 5% by weight or less. If the amount is less than the above 0.005% by weight, the intended effect of the present invention tends not to be sufficiently exerted, which is not preferable. If the amount exceeds 20% by weight, it often causes troubles in the preparation, which is not preferable. .

B. The hair restorer of the present invention comprises an amine oxide represented by the formula (I). The amine oxide (I) can be roughly classified into three modes.
That is, dimethylalkylamine oxide (a) in which R ² of amine oxide (I) is a methyl group and n = 0; similarly, R ² is a hydroxyethyl group;
Dihydroxyethylalkylamine oxide (b), which is 0, or dimethylalkylpolyoxyethyleneamine oxide (c), wherein R ² is a methyl group and n> 1.

R ¹ which is a straight-chain alkyl group or a branched-chain alkyl group having 2 to 24 carbon atoms is an ethyl group,
Propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl , Eicosacyl, heneicosacyl, docosacyl, tricosanyl or tetracosanyl; linear alkyl groups; isopropyl, isobutyl, sec-butyl, tert-butyl, isopentyl, neopentyl, tert-pentyl, isohexyl Examples include a branched alkyl group such as a group.

The polymerization number n of the monooxyethylene group A is in the range of 1 to 5 when the amine oxide (I) is dimethylalkylpolyoxyethylene amine oxide.

Specifically, dimethylalkylamine oxide (a) includes N, N-dimethyl-2-ethylamine oxide, N, N-dimethyl-2-butylamine oxide, N, N-dimethyl-2-hexylamine oxide , N, N-dimethyl-2-octylamine oxide,
N, N-dimethyl-2-decylamine oxide, N, N
-Dimethyl-2-dodecylamine oxide, N, N-dimethyl-2-tetradecylamine oxide, N, N-dimethyl-2-hexadecylamine oxide, N, N-dimethyl-2-octadecylamine oxide, N, N -Dimethyl-2-eicosylamine oxide, N, N-dimethyl-2-tetraeicosylamine oxide, N, N-
Dimethyl-2-decyltetradecylamine oxide and the like can be exemplified.

The dihydroxyethylalkylamine oxide (b) includes N, N-dihydroxyethyl-2-ethylamine oxide, N, N-dihydroxyethyl-2-butylamine oxide, N, N-dihydroxyethyl-2-hexyl. Amine oxide, N, N-dihydroxyethyl-2-hexylamine oxide, N, N
-Dihydroxyethyl-2-octylamine oxide,
N, N-dihydroxyethyl-2-ethyloctylamine oxide, N, N-dihydroxyethyl-2-decylamine oxide, N, N-dihydroxyethyl-2-dodecylamine oxide, N, N-dihydroxyethyl-
2-tetradecylamine oxide, N, N-dihydroxyethyl-2-hexadecylamine oxide, N, N-
Dihydroxyethyl-2-octadecylamine oxide, N, N-dihydroxyethyl-2-eicosylamine oxide, N, N-dihydroxyethyl-2-decyldecylamine oxide, N, N-dihydroxyethyl-
Examples include 2-decyldecylamine tetraeicosylamine oxide.

The dimethylalkyl polyoxyethylene amine oxide (c) includes dimethylethyl polyoxyethylene (1.5 mol) amine oxide, dimethylbutyl polyoxyethylene (3 mol) amine oxide, dimethylhexyl polyoxyethylene (c). 5 mol) amine oxide, dimethyl octyl polyoxyethylene (3 mol) amine oxide, dimethyl decyl polyoxy ethylene (1.5 mol) amine oxide, dimethyl dodecyl polyoxy ethylene (3 mol) amine oxide, dimethyl tetradecyl polyoxy ethylene (5 mol) amine oxide, dimethyl hexadecyl polyoxyethylene (3 mol) amine oxide, dimethyl octadecyl polyoxyethylene (1.5 mol) amine oxide, dimethyl eicosyl polio Shiechiren (1.5 mol) amine oxide, dimethyl tetra et eicosyl polyoxyethylene (1.5 moles) amine oxide can be exemplified.

These amine oxides (I) can be used alone in the hair restorer of the present invention, but can also be used in combination with a plurality of amine oxides (I).

The amount of the amine oxide (I) in the hair growth composition of the present invention may be appropriately changed according to the specific combination of the amine oxide (I) and the specific mode of the hair growth composition of the invention. Although it is not particularly limited in what is to be performed, generally 0.0001 in the total amount of the hair restoration
% By weight and 20% by weight or less, preferably 0.01% by weight or less.
It is particularly preferably at least 5% by weight and not more than 5% by weight. If the amount is less than 0.0001% by weight based on the total amount of the hair restorer, the intended effect of the present invention tends not to be sufficiently exerted, which is not preferable. Even if the amount exceeds 20% by weight, the amount increases. This is not preferable because no enhanced effect is observed. Thus, by combining the above-mentioned plant extract and the amine oxide (I) in combination, a hair restorer having an extremely excellent hair loss preventing effect and a hair growth effect is provided.

In the hair restoration of the present invention, the desired effect of the present invention is intended for the purpose of exhibiting the general effect of the hair restoration component normally incorporated in the hair restoration. Can be blended as long as is not impaired. For example, other alkoxycarbonyl pyridine N- oxide, Kapuroniumu chloride, assembly extract, vasodilators such as acetylcholine derivatives; serine, amino acids such as methionine, vitamin B _6, vitamin E or a derivative thereof, vitamins such as biotin; pantothenic An acid or a derivative thereof;
Glycyrrhetinic acid or a derivative thereof; nicotinic acid esters such as benzyl nicotinate; skin function enhancers such as cepharanthin; and female hormones such as estradiol can also be incorporated in the hair restorer of the present invention.

[0018] Also, plant extracts usually blended in hair restorations, such as Altea extract, yokuinin extract, peppermint extract, ginkgo extract, capsicum extract, aloe extract, wolfberry extract, mugwort extract, Rice extract,
Mankeishi extract, Mannen wax extract, Kosaiho extract, Enishida extract, Gentian extract, Tanjin extract, Loofah extract, Kikyo extract, Pine extract, Kuddin extract, Touki extract, safflower extract, Barberry extract Material, betel nut extract, eucalyptus extract, sprouts extract, mokutsu extract, gossip extract, psycho extract, tea extract, licorice extract, hop extract, chrysanthemum extract, senega extract, sesame extract, A hair extract of the present invention is blended with an extract of Sengoku, an extract of cashew, an extract of wolfberry, an extract of mugwort, an extract of cuckoo, an extract of maikai, an extract of saffron, an extract of rosemary, an extract of magnolia, a mallow extract, etc. be able to.

Also, hinokitiol. Hexachlorophen. Antibacterial agents such as benzalkonium chloride, cetylpyridinium chloride, undecylenic acid, trichlorocarbanide and bitionol; cooling agents such as menthol; salicylic acid, zinc or derivatives thereof; drugs such as lactic acid or its alkyl ester; organic acids such as citric acid Protease inhibitors such as tranexamic acid; amino acids such as arginine; oils such as olive oil, squalane, liquid paraffin, isopropyl myristate, higher fatty acids and higher alcohols;
Polyhydric alcohols such as glycerin and propylene glycol, other surfactants, humectants, thickeners, fragrances, antioxidants, ultraviolet absorbers, dyes, ethanol, water, etc., do not impair the intended effects of the present invention. Can be appropriately blended.

The form of the hair restorer of the present invention is not particularly limited as long as it can be applied to the outer skin such as a liquid, an emulsion, an ointment, and the like. Of the present invention can be prepared. In addition, the hair restoration of the present invention can be applied in various fields such as pharmaceuticals, quasi-drugs, and cosmetics.

The hair restorer of the present invention can be used for the treatment and prevention of alopecia, for example, the treatment and prevention of androgenetic alopecia, the treatment and prevention of diffuse alopecia common to women, the treatment of alopecia areata, etc. Can be widely used. It should be noted that the names of hair loss diseases shown here are examples, and diseases to which the hair restoration of the present invention can be applied are not limited to these hair loss diseases.

The hair restorer of the present invention is generally administered by transdermal administration such as directly applying or spraying on the skin. The dose of the hair restorer of the present invention should be appropriately determined according to individual differences such as age and degree of hair loss, but the dose for general adults is 0.01 to 100 mg / kg body weight. Daily, preferably 0.1 to 10 mg / day, which can be administered once a day or divided into 2 to 4 times a day.

[0023]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to Examples and the like, but the technical scope of the present invention should not be limited by these Examples and the like. First, prior to the disclosure of each embodiment, tests for examining the hair-growing effect of these embodiments and the like will be described.

1. Hair growth test Using C3H / HeNCrJ mice in the telogen phase of the hair cycle, the method of Ogawa et al. (Normal and Abnormal)
Epidermal Differentiation (Normal and
Abnormal Epidermal Differentiation, M. Seiji and
A hair growth test is performed according to IABernstein, pp. 159-170, 1982, published by The University of Tokyo. That is, mice are group 1
The number of mice was zero, and the mice were uncoated, divided into groups of Examples and Comparative Examples. The backs of the mice were shaved with a hair clipper and a shaver, and 0.1 ml of each sample was applied once a day. The hair growth effect of each sample was calculated as the area ratio of the hair growth part on the back of the mouse (the area of the hair growth part / the area of the shaved part × 100 = hair growth rate).
Assess by

2. Hair Restoration Effect Test In order to further examine the hair restoration effect such as the hair loss prevention effect and the hair growth effect of the hair restorer of the present invention, a tricogram test and a hair loss prevention test are performed on healthy individuals. Tricogram test The hair removed before and after use of the hair restoration was observed under a microscope,
Count the number of telogen follicles from the morphology of the follicles (the telogen follicles are the roots of hair that has stopped growing, and those who report hair loss have a higher percentage of this telogen follicle than normal people. Is observed.), And the hair growth effect of the hair growth material is compared by increasing or decreasing the ratio. Specifically, the hair restorer of the present invention was applied to the scalp of 10 male subjects twice a day, 5 ml per time, for 6 consecutive months, and applied to one subject immediately before application and immediately before the end of application for 6 months. One hundred hairs are withdrawn and each hair root is examined as described above.

Hair Loss Prevention Test The change in the number of hair loss before and after use of the hair restorer during hair washing was used as an index of the hair loss preventive effect of the hair restorer. That is, two months before the start of the tricogram test was defined as a sample non-application period, and the subject was washed every day one week before the start of the test and six days after the start, and the hair removed at that time was collected, and the thickness was 50 μm or more. The number of hair was counted. Then, the change rate of the average number of hair removals per day for each subject (the average number of hair removals during the hair application period / the average number of hair removals during the no application period × 100) was determined.

[Examples 1 to 19] Table 1 (Table 1-1)
A hair restorer was prepared according to the formulation shown in 2, 3).

[Table 1]

[0028]

[Table 2]

[0029]

[Table 3]

<Production method> To 95% ethanol, an amine oxide (I), an adduct of hydrogenated castor oil and ethylene oxide (40 mol), and a peony extract and / or a red pepper extract were added, and dissolved by stirring. Exchanged water was added and mixed to prepare a desired hair restorer.

The results of the hair growth test of the hair growth preparations of the examples shown in Table 1 are shown in Table 2 together with the results of the comparative examples.

[Table 4]

As described above, the hair restorer of the present invention containing the amine oxide (I) and the peony extract and / or the peanut extract which is a specific plant extract is a comparative example containing only one of these components. Compared to the hair nourishing
It was found that the hair growth effect of shifting the hair cycle from the telogen to the anagen was excellent.

Next, the above hair growth effect test was conducted on the hair growth material of Example 19 shown in Table 1. The result is the third
Shown in the table.

[Table 5]

As shown in Table 3, by applying the hair restorer of Example 19 to the subject, the number of hair removals decreased,
It was also found that the proportion of hair roots in the rest period of the hair cycle was also reduced, and it was revealed that the hair growth preparation of the present invention had an excellent hair growth effect. In view of the ingredients shown in Table 1 and the results of the hair growth test in each example shown in Table 2, the excellent hair growth observed in the hair growth preparation of Example 19 was considered. It is clear that the effect is also observed in the hair restoration in other examples.

Hereinafter, the formulations of the hair growth preparation of the present invention having various formulations are described. Each hair growth preparation had excellent hair growth and hair growth effects in the hair growth test and the hair growth effect test.
In addition, these hair nourishes which do not particularly describe the production method were produced by a conventional method according to the dosage form.

Example 20 Hair Tonic Weight% Peony (1,3-butylene glycol solution) 0.01 N, N-diethyl peroxymethyl-2-tetraeicosylamine oxyt 1.0 N, N-dimethyl-2- Tesylamine oxytol 1.0 Hinokitiol 1.0 Vitamin B6 0.2 Vitamin E acetate 0.02 Menthol 0.2 Assembly extract 1.0 Salicylic acid 0.1 Maikamika extract (ethanol extract) 0.5 Propylene glycol 2.0 Sodium hyaluronate 0.01 polyoxyethylene (10 mol) monostearate 2.0 75% ethanol Residue

[Example 21] Hair tonic wt% buttonpi extract (ethanol extract) 5.0 N, N-dimethyl-2-decylamine oxyt 0.05 dimethyloctylpolyoxyethylene (3 mol) amine oxyt 05 Hinokitiol 1.0 Vitamin B6 0.2 Vitamin E acetate 0.02 Menthol 0.2 Salicylic acid 0.1 Bracken extract (ethanol extract) 0.5 Propylene glycol 2.0 Sodium hyaluronate 0.01 Polyoxyethylene ( 10 mol) monostearate 2.0 70% ethanol residue

[Example 22] Hair tonic wt% buttonpi extract (1,3-butylene glycol solution) 2.5 Peony extract (ethanol extract) 2.5 N, N-dimethyl-2-todecylamine oxyto2 2.5 N, N-dimethyl-2-decyltetradecylamine oxyto 2.5 N, N-dimethylhydroxymethyl-2-hexadecylamine oxyto 2.5 N, N-dimethyl 2-hydroxymethyl-2-eicosylamine oxyto 2.5 Dimethylhexylpolyoxyethylene (5 mol) amine oxyto 2.5 dimethyltetradecylpolyoxyethylene (3 mol) amine oxy 2.5 N, N-dimethyl-2-decylamine oxyto 1.0 Altea extract (ethanol extract ) 0.05 Propylene glycol 2.0 65% ethanol Residue

Example 23 Hair Tonic 95% by weight 95% Ethanol 50.0 Monoammonium glycyrrhizinate 0.05 Bompi extract (Ethanol extract) 0.05 Peony (1,3-butylene glycol solution) 0.02 Saffron Extract (ethanol extract) 0.02 Rosemary extract (ethanol extract) 0.02 Peppermint extract (ethanol extract) 0.02 Touki extract (ethanol extract) 0.02 Altea extract (ethanol extract) Liquid) 0.02 Diou extract (ethanol extract) 0.02 Yokuinin extract (ethanol extract) 0.02 Sodium lauryl sulfate 0.1 N, N-dimethyl-2-decyltetradecylamine oxyto 0.5 N , N-Dihydroxymethyl-2-hexadecylamineoxytoxin 0 5-di-methylhexyl Ho ° polyoxyethylene (5 moles) Amin'okishito Bu 0.5 hydrogenated castor oil ethyleneoxy preparative Bu (40 mol) adduct 0.5 Succinic acid q.s. perfume and dye qs Purified water Balance

[Example 24] O / W emulsion type hair nourisher% by weight (A phase) N, N-dimethyl-2-hexylamine oxyt 1.0 N, N-diethyl humanoxymethyl-2-tesylamine oxyt 5 polyoxyethylene (60 mol) addition-hardened castor oil 2.0 glycerin 10.0 dipropylene glycol 10.0 1,3-butylene glycol 4.0 peony extract (ethanol extract) 0.01 buttonpipe extract (ethanol (Extract) 0.2 polyethylene glycol 1500 5.0 (phase B) cetyl isooctanoate 10.0 squalane 5.0 petrolatum 2.0 propylparaben 2.0 (phase C) carboxyvinyl polymer 1% aqueous solution 30.0 hexametaline Sodium acid 0.03 Purified water 8.35 (D phase) Purified water 4.5 (E phase) KOH 0.12 Purified water residue

<Preparation Method> The phases A and B were each dissolved by heating at 60 ° C., mixed, and treated with a homomixer to prepare a gel. Phase D was gradually added to the gel and dispersed with a homomixer. Next, C previously dissolved in this gel dispersion
The phase was added, and the previously dissolved phase E was added and emulsified with a homomixer to produce a desired O / W emulsion type hair restorer.

[Example 25] Cream hair restorer (% by weight) (A phase) dimethylhexylpolyoxyethylene (5 mol) amine oxyt 2.5 liquid paraffin 5.0 cetostearyl alcohol 5.5 glyceryl monostearate 3.0 EO (20 mol) -2-octyl decyl ether 3.0 propylparaben 0.3 Perfume 0.1 (Phase B) Peony extract (1,3-butylene glycol solution) 0.03 Peony extract (ethanol extract) 0.04 Glycerin 8.0 Dipropylene glycol 20.0 Polyethylene glycol 4000 5.0 Sodium hexametaphosphate 0.005 Purified water residue

<Production Method> The phases A and B were each dissolved by heating, mixed, and emulsified with a homomixer to obtain a desired creamy hair restorer.

[Example 26] Aerosol hair restoration weight% (stock solution formulation) 95% ethanol 50.0 Glycyrrhetinic acid 0.1 Red pepper extract (ethanol extract) 0.025 Peony extract (ethanol extract) 0.055 Assembly extract 0.1 Sodium lauryl sulfate 0.1 N, N-Dimethyl-2-tetradecylamine oxyto 0.2 N, N-Dimethyl peroxymethyl-2-decylamine oxyto 0.3 Cimethylmethyl peroxypolyoxyethylene (5 mol) Amine oxyto 0.1 Hardened castor oil Ethylene oxyto (40 mol) adduct 0.5 Suitable for lactic acid Suitable for sodium lactate Suitable for fragrance and dye Suitable for purified water Residue (filling formula) Stock solution 50.0 Liquefied petroleum gas 50.0

<Preparation Method> A stock solution was prepared by dissolving the stock solution formulation, filled into a can, fitted with a valve, and then filled with gas to prepare a desired aerosol hair growth material.

[0046]

Industrial Applicability According to the present invention, there is provided a hair restorer having a hair growth effect such as an excellent hair loss prevention effect and a hair growth effect.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Yosuke Nakazawa 1050 Nippa-cho, Kohoku-ku, Yokohama, Kanagawa Prefecture Inside Shiseido First Research Center Co., Ltd. (72) Inventor Shunsuke 1050 Nippacho, Kohoku-ku, Yokohama-shi, Kanagawa Inside Shiseido Daiichi Research Center Co., Ltd. (72) Inventor Masaaki Uemura 1050 Nippacho, Kohoku-ku, Yokohama, Kanagawa Prefecture Inside Shiseido Daiichi Research Center Co., Ltd. (72) Inventor Masahiro Tajima Niiwacho, Kohoku-ku, Yokohama, Kanagawa Prefecture 1050, Shiseido Daiichi Research Center Co., Ltd.

Claims (1)

[Claims] 1. A hair restorer comprising the following components: Peony extract and / or peanut extract One or two amine oxides represented by the following formula (I):
Species or more: (Wherein, R ¹ is a linear or branched alkyl group having 2 to 24 carbon atoms, R ² is a methyl group or a hydroxyethyl group, A is a monooxyethylene group, and n is 0 or more and 5 or less. Represents a number).