JPH11199468A - Skin cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To prepare a skin cosmetic stable even after a long term preservation, capable of preventing inflammatory of the skin by ultraviolet rays, preventing and suppressing inflammatory pigmentation, and useful for a cosmetic lotion, an emulsion, a cream, a pack, an essence or the like by including methylhesperidin, a derivative of ascorbic acid and an organic acid salt. SOLUTION: This skin cosmetic contains (A) methylhesperidin of preferably 0.01-10.0 wt.%, (B) a derivative of ascorbic acid of preferably 0.1-6.0 wt.% and (C) an organic acid salt of preferably 0.1-6.0 wt.%. The component B is preferably an L-ascorbyl phosphate salt or an L-ascorbyl sulfate salt (e.g. magnesium L-ascorbyl phosphate and sodium ascorbyl sulfate). The component C is preferably a salt of tartaric acid, lactic acid, glycolic acid or the like. If necessary, the skin cosmetic can contain a medicinal agent, an antiinflammatory agent, an oily medicine, a moisture-keeping agent, a surfactant, a microbicidal agent, an antiseptic agent, an ultraviolet absorbent, an antioxidant or the like.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention is stable even when stored for a long period of time, and is excellent in the effect of preventing skin inflammation due to ultraviolet rays and the effect of preventing / suppressing inflammatory pigmentation. The present invention relates to a skin cosmetic having no irritation.

[0002]

2. Description of the Related Art One of the causes of skin inflammation is the transmission of ultraviolet rays (especially UVB) into the skin. In order to prevent inflammation, it is necessary to prevent the transmission of ultraviolet light by using an ultraviolet absorber, a pigment or the like. However, when inflammation occurs, arachidonic acid present in the cell membrane in the skin is released,
Various prostaglandins are produced via the cyclooxygenase system. On the other hand, various leukotrienes are also produced by the lipoxygenase system. These chemical mediators cause vasodilation of arterioles and cause erythema, as well as increasing vascular permeability and causing edema.
Causes inflammation. These chemical mediators act on melanocytes in various ways and also contribute to melanin synthesis in melanocytes. Melanin produced by oxidation of tyrosine in melanocytes is transferred to epidermal cells, which changes the color of the skin and causes darkening. It is known that as a substance having a function of preventing oxidation, a substance that captures and eliminates active oxygen, a substance that has an activity inhibiting effect on an enzyme tyrosinase involved in melanin biosynthesis, and the like are effective.

JP-A-55-87712 proposes a cosmetic composition containing superoxide dismutase (SOD) for capturing and eliminating active oxygen.
Quercetin (JP-A-55-92305), vitamin C derivative (JP-A-56-135411), and hydroquinone derivative (JP-A-60-56912) are compounded as substances having a tyrosinase activity inhibitory action. Whitening cosmetics have been proposed. For the purpose of suppressing inflammation due to ultraviolet rays, cosmetics containing fine particles of titanium oxide for blocking ultraviolet rays, ultraviolet absorbers and the like have been proposed.

[0004]

However, when these components were used alone, the effect of suppressing inflammation and the effect of whitening due to ultraviolet rays were not sufficiently recognized. SOD and vitamin C derivatives had insufficient storage stability. Quercetin and the glycoside rutin have safety concerns,
The solubility in water was insufficient for practical use. Cosmetics containing fine particles of titanium oxide, ultraviolet absorbers, etc. have the effect of preventing inflammation by suppressing the transmission of ultraviolet light to the skin, but the effect is not sufficient, and conventional fat-soluble ultraviolet light Since the absorbent was used, there was a sticky feeling when applied to the skin, and the feeling of use was not good. In the above situation, it is stable even if stored for a long time,
In addition, there has been a demand for a skin cosmetic which has an excellent effect of preventing skin inflammation due to ultraviolet rays and an effect of preventing / suppressing inflammatory pigmentation, and has no undesirable side effects or skin irritation on the human body.

[0005]

Means for Solving the Problems The present inventors have conducted intensive studies to obtain cosmetics free from the above-mentioned problems, and as a result, the use of methyl hesperidin, an ascorbic acid derivative and an organic acid salt satisfies the above requirements. It has been found that an excellent skin cosmetic can be obtained, and the present invention has been completed.

That is, the present invention is a skin cosmetic containing methyl hesperidin as the component (A), an ascorbyl derivative as the component (B), and an organic acid salt as the component (C).

[0007]

Embodiments of the present invention will be described below. Methyl hesperidin used in the present invention is a known substance listed in the official food additives, and is mainly a mixture of three chalcone compounds and three flavanone compounds. The blending amount of methyl hesperidin with respect to the total composition of the skin cosmetic composition of the present invention is usually desirably in the range of 0.01 to 10.0% by weight (hereinafter simply indicated as%).

The ascorbic acid derivative used in the present invention is preferably L-ascorbyl phosphate or L-ascorbyl sulfate, such as magnesium L-ascorbyl phosphate, sodium L-ascorbyl phosphate, sodium L-ascorbyl sulfate. And so on. These can be used alone or in combination of two or more. The amount of the ascorbic acid derivative relative to the total composition of the skin cosmetic of the present invention is usually desirably in the range of 0.1 to 6.0%.

The organic acid salt used in the present invention is not particularly limited, but an organic acid salt in which the ratio of the number of carboxyl groups to hydroxyl groups is 1 is particularly desirable. For example, tartaric acid, lactic acid,
It is a salt such as glycolic acid. At this time, as a counter ion, an inorganic ion such as a sodium ion, a potassium ion, a calcium ion and an ammonium ion, and an organic ion such as a triethanol ammonium ion are applied. These organic acid salts can be used alone or in combination of two or more. The above-mentioned organic acid salts also include optically active substances and racemic forms thereof. The amount of the organic acid salt relative to the total composition of the skin cosmetic composition of the present invention is usually desirably in the range of 0.1 to 6.0%.

[0010] In the present invention, furthermore, a medicinal agent, an anti-inflammatory agent, an oil agent, a humectant, a surfactant, a bactericide, a preservative, an ultraviolet absorber, an antioxidant, an organic and Inorganic powders, polymers, sequestering agents, dyes, fragrances, and the like can be added as necessary. The skin cosmetic of the present invention is applied to lotions, emulsions, creams, packs, essences and the like.

[0011]

Hereinafter, the present invention will be described with reference to examples.
Prior to that, the evaluation method is shown. Note that the present invention is not limited to these examples.

Evaluation method (1) UV erythema suppression test A sample application site and a base application site were set on the back skin of ten Hartley-type guinea pigs from which hair had been removed, and twice the minimum erythema dose (MED) of ultraviolet rays in the UVB region. Irradiation was carried out at two locations each. The sample and the base were applied 24 hours before and immediately after the irradiation, and the state of erythema was evaluated 24 hours after the irradiation according to the following criteria. The results were shown as the average of the evaluation points.

[Table 1]

(2) Skin color lightness reduction test subjects 20
The reference lightness (V0 value, V0 ′ value) of the sample application planned portion and the base application planned portion of the upper arm inner skin was measured. Then, the minimum erythema amount of UV in the UVB region of 1.5
A double dose was continuously irradiated for three days. The sample was applied 24 hours before irradiation and three times a day immediately after irradiation for 1 week continuously, and the skin lightness (Vn value, Vn 'value) of the sample-applied part and the base-applied part skin was measured one week after the start of irradiation. Then, V0'-Vn 'is defined as the lowering value of the base application portion, and V0'
0-Vn was defined as ΔV ′ and ΔV, respectively, and evaluation of suppression of decrease in skin color brightness was performed according to the following criteria. The lightness (V value) of the skin was calculated from X, Y, and Z values obtained by measuring with a high-speed spectral colorimeter. In addition, the evaluation
The average value of the evaluation scores of one person after one week was shown.

[Table 2]

(3) Storage stability test (sediment)
It was left at 0 ° C. for 6 months, and the presence or absence of the precipitate was visually inspected according to the following evaluation criteria.

[Table 3] (Appearance) The appearance of the sample, that is, the degree of coloring was visually examined with the following evaluation criteria.

[Table 4]

(4) Optical Patch Test A sample of 0.05 g was applied to the skin of the forearm flexion side of 25 subjects using a patch test patch with a circular lint cloth having a diameter of 1.0 cm. After the time-blocking was applied, summer sunlight was irradiated for 6 hours (3 hours a day for 2 days). The evaluation was performed according to the following criteria, and the results were shown as (±) or more 24 hours after irradiation.

[Table 5]

Examples 1-2, Comparative Examples 1-5 (Lotion) In the raw material composition shown in Table 6, the active ingredients shown in Table 7 were blended and mixed and dissolved by a usual method to prepare a lotion. The above-described tests were performed. Table 7 shows the results.

[0017]

[Table 6]

[0018]

[Table 7]

As shown in Table 7, the skin cosmetics of the present invention of Examples 1 and 2 showed clearly good results in various tests as compared with Comparative Examples, and did not cause skin irritation.

[0020]

As described above, the skin cosmetic of the present invention is stable even when stored for a long period of time, and is excellent in the effect of preventing skin inflammation due to ultraviolet rays and the effect of preventing and suppressing inflammatory pigmentation. Has no undesirable side effects or skin irritation on the human body.

Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/00 A61K 7/00 XW 31/19 31/19 31/375 ADA 31/375 ADA 31/665 31/665 31/70 ABE 31 / 70 ABE

Claims (1)

[Claims] 1. Component (A) methyl hesperidin,
A skin cosmetic containing an ascorbic acid derivative as the component (B) and an organic acid salt as the component (C).