JPH11501904A - クラブラン酸の塩、バンコマイシンおよび１種またはそれ以上のベータ−ラクタム系抗生物質を含んでなる医薬処方 - Google Patents

クラブラン酸の塩、バンコマイシンおよび１種またはそれ以上のベータ−ラクタム系抗生物質を含んでなる医薬処方

Info

Publication number: JPH11501904A
Authority: JP; Japan
Prior art keywords: vancomycin; clavulanic acid; clavulanate; formulation; lactam antibiotics
Prior art date: 1995-01-19
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Pending

Application number

JP8522059A

Other languages

English (en)

Japanese (ja)

Inventor

ベリー，バレリー

ブライアント，ジョアンナ

ウッドナット，ゲイリー

ペアソン，スチュアート

シンプソン，イエイン

ムーア，ローランド

Original Assignee

スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-01-19

Filing date

1996-01-17

Publication date

1999-02-16

1996-01-17 Application filed by スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー filed Critical スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー

1999-02-16 Publication of JPH11501904A publication Critical patent/JPH11501904A/ja

Status Pending legal-status Critical Current

Links

108010059993 Vancomycin Proteins 0.000 title claims abstract description 55
229960003165 vancomycin Drugs 0.000 title claims abstract description 55
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 title claims abstract description 55
HZZVJAQRINQKSD-PBFISZAISA-N clavulanic acid Chemical class OC(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 HZZVJAQRINQKSD-PBFISZAISA-N 0.000 title claims abstract description 41
239000003782 beta lactam antibiotic agent Substances 0.000 title claims abstract description 22
239000002132 β-lactam antibiotic Substances 0.000 title claims abstract description 22
229940124586 β-lactam antibiotics Drugs 0.000 title claims abstract description 22
MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 title claims abstract 9
239000008194 pharmaceutical composition Substances 0.000 title claims description 10
HZZVJAQRINQKSD-UHFFFAOYSA-N Clavulanic acid Natural products OC(=O)C1C(=CCO)OC2CC(=O)N21 HZZVJAQRINQKSD-UHFFFAOYSA-N 0.000 claims abstract description 38
239000000203 mixture Substances 0.000 claims abstract description 34
238000009472 formulation Methods 0.000 claims abstract description 29
229960003324 clavulanic acid Drugs 0.000 claims abstract description 27
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208000015181 infectious disease Diseases 0.000 claims abstract description 18
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238000011282 treatment Methods 0.000 claims abstract description 12
ABVRVIZBZKUTMK-JSYANWSFSA-M potassium clavulanate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21 ABVRVIZBZKUTMK-JSYANWSFSA-M 0.000 claims abstract description 7
238000007911 parenteral administration Methods 0.000 claims abstract description 5
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OHKOGUYZJXTSFX-KZFFXBSXSA-N ticarcillin Chemical compound C=1([C@@H](C(O)=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)C=CSC=1 OHKOGUYZJXTSFX-KZFFXBSXSA-N 0.000 claims description 17
238000000034 method Methods 0.000 claims description 12
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LSQZJLSUYDQPKJ-NJBDSQKTSA-N amoxicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 LSQZJLSUYDQPKJ-NJBDSQKTSA-N 0.000 claims description 10
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LSQZJLSUYDQPKJ-UHFFFAOYSA-N p-Hydroxyampicillin Natural products O=C1N2C(C(O)=O)C(C)(C)SC2C1NC(=O)C(N)C1=CC=C(O)C=C1 LSQZJLSUYDQPKJ-UHFFFAOYSA-N 0.000 claims description 9
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239000002552 dosage form Substances 0.000 claims description 6
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ILVPFTMKCHREDJ-UHFFFAOYSA-N methyl 5-amino-2-fluorobenzoate Chemical compound COC(=O)C1=CC(N)=CC=C1F ILVPFTMKCHREDJ-UHFFFAOYSA-N 0.000 claims description 5
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RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 abstract description 8
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BYHDFCISJXIVBV-YWUHCJSESA-M amoxicillin sodium Chemical compound [Na+].C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=C(O)C=C1 BYHDFCISJXIVBV-YWUHCJSESA-M 0.000 abstract 1
ZBBCUBMBMZNEME-QBGWIPKPSA-L ticarcillin disodium Chemical compound [Na+].[Na+].C=1([C@@H](C([O-])=O)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)C=CSC=1 ZBBCUBMBMZNEME-QBGWIPKPSA-L 0.000 abstract 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 47
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-1 azulocillin Chemical compound 0.000 description 9
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ODFHGIPNGIAMDK-NJBDSQKTSA-N azidocillin Chemical compound C1([C@@H](N=[N+]=[N-])C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 ODFHGIPNGIAMDK-NJBDSQKTSA-N 0.000 description 1
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WZPBZJONDBGPKJ-VEHQQRBSSA-N aztreonam Chemical compound O=C1N(S([O-])(=O)=O)[C@@H](C)[C@@H]1NC(=O)C(=N/OC(C)(C)C(O)=O)\C1=CSC([NH3+])=N1 WZPBZJONDBGPKJ-VEHQQRBSSA-N 0.000 description 1
229960003644 aztreonam Drugs 0.000 description 1
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229960002588 cefradine Drugs 0.000 description 1
SYLKGLMBLAAGSC-QLVMHMETSA-N cefsulodin Chemical compound C1=CC(C(=O)N)=CC=[N+]1CC1=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)[C@@H](C=3C=CC=CC=3)S(O)(=O)=O)[C@H]2SC1 SYLKGLMBLAAGSC-QLVMHMETSA-N 0.000 description 1
229960003202 cefsulodin Drugs 0.000 description 1
229960001668 cefuroxime Drugs 0.000 description 1
JFPVXVDWJQMJEE-IZRZKJBUSA-N cefuroxime Chemical compound N([C@@H]1C(N2C(=C(COC(N)=O)CS[C@@H]21)C(O)=O)=O)C(=O)\C(=N/OC)C1=CC=CO1 JFPVXVDWJQMJEE-IZRZKJBUSA-N 0.000 description 1
229960002620 cefuroxime axetil Drugs 0.000 description 1
229940106164 cephalexin Drugs 0.000 description 1
ZAIPMKNFIOOWCQ-UEKVPHQBSA-N cephalexin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CC=CC=C1 ZAIPMKNFIOOWCQ-UEKVPHQBSA-N 0.000 description 1
229940124587 cephalosporin Drugs 0.000 description 1
150000001780 cephalosporins Chemical class 0.000 description 1
RDLPVSKMFDYCOR-UEKVPHQBSA-N cephradine Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@@H]3N(C2=O)C(=C(CS3)C)C(O)=O)=CCC=CC1 RDLPVSKMFDYCOR-UEKVPHQBSA-N 0.000 description 1
229960003326 cloxacillin Drugs 0.000 description 1
LQOLIRLGBULYKD-JKIFEVAISA-N cloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=CC=CC=C1Cl LQOLIRLGBULYKD-JKIFEVAISA-N 0.000 description 1
238000011260 co-administration Methods 0.000 description 1
239000003086 colorant Substances 0.000 description 1
238000011284 combination treatment Methods 0.000 description 1
HGBLNBBNRORJKI-WCABBAIRSA-N cyclacillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)C1(N)CCCCC1 HGBLNBBNRORJKI-WCABBAIRSA-N 0.000 description 1
229960004244 cyclacillin Drugs 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
239000012895 dilution Substances 0.000 description 1
238000010790 dilution Methods 0.000 description 1
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
229960002457 epicillin Drugs 0.000 description 1
RPBAFSBGYDKNRG-NJBDSQKTSA-N epicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CCC=CC1 RPBAFSBGYDKNRG-NJBDSQKTSA-N 0.000 description 1
230000008029 eradication Effects 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
230000007773 growth pattern Effects 0.000 description 1
230000002458 infectious effect Effects 0.000 description 1
201000007119 infective endocarditis Diseases 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
229960001977 loracarbef Drugs 0.000 description 1
JAPHQRWPEGVNBT-UTUOFQBUSA-N loracarbef Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3C(=C(Cl)CC[C@@H]32)C([O-])=O)=O)[NH3+])=CC=CC=C1 JAPHQRWPEGVNBT-UTUOFQBUSA-N 0.000 description 1
229960000198 mezlocillin Drugs 0.000 description 1
YPBATNHYBCGSSN-VWPFQQQWSA-N mezlocillin Chemical compound N([C@@H](C(=O)N[C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C=1C=CC=CC=1)C(=O)N1CCN(S(C)(=O)=O)C1=O YPBATNHYBCGSSN-VWPFQQQWSA-N 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
235000019371 penicillin G benzathine Nutrition 0.000 description 1
229940056360 penicillin g Drugs 0.000 description 1
229940056367 penicillin v Drugs 0.000 description 1
229950009506 penicillinase Drugs 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
BPLBGHOLXOTWMN-MBNYWOFBSA-N phenoxymethylpenicillin Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)COC1=CC=CC=C1 BPLBGHOLXOTWMN-MBNYWOFBSA-N 0.000 description 1
239000002953 phosphate buffered saline Substances 0.000 description 1
229960002292 piperacillin Drugs 0.000 description 1
WCMIIGXFCMNQDS-IDYPWDAWSA-M piperacillin sodium Chemical compound [Na+].O=C1C(=O)N(CC)CCN1C(=O)N[C@H](C=1C=CC=CC=1)C(=O)N[C@@H]1C(=O)N2[C@@H](C([O-])=O)C(C)(C)S[C@@H]21 WCMIIGXFCMNQDS-IDYPWDAWSA-M 0.000 description 1
239000003910 polypeptide antibiotic agent Substances 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
DWHGNUUWCJZQHO-ZVDZYBSKSA-M potassium;(2s,5r,6r)-6-[[(2r)-2-amino-2-(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid;(2r,3z,5r)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylate Chemical compound [K+].[O-]C(=O)[C@H]1C(=C/CO)/O[C@@H]2CC(=O)N21.C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=C(O)C=C1 DWHGNUUWCJZQHO-ZVDZYBSKSA-M 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
HOCWPKXKMNXINF-XQERAMJGSA-N propicillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C(CC)OC1=CC=CC=C1 HOCWPKXKMNXINF-XQERAMJGSA-N 0.000 description 1
229960003672 propicillin Drugs 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
238000009097 single-agent therapy Methods 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008223 sterile water Substances 0.000 description 1
230000001954 sterilising effect Effects 0.000 description 1
238000004659 sterilization and disinfection Methods 0.000 description 1
238000011421 subcutaneous treatment Methods 0.000 description 1
229960004932 sulbenicillin Drugs 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
239000003826 tablet Substances 0.000 description 1
238000012360 testing method Methods 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
230000035899 viability Effects 0.000 description 1
238000005303 weighing Methods 0.000 description 1
229910052724 xenon Inorganic materials 0.000 description 1
229960004529 xenon Drugs 0.000 description 1
FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

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Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Gastroenterology & Hepatology (AREA)
Organic Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP8522059A 1995-01-19 1996-01-17 クラブラン酸の塩、バンコマイシンおよび１種またはそれ以上のベータ−ラクタム系抗生物質を含んでなる医薬処方 Pending JPH11501904A (ja)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9500978.3A GB9500978D0 (en)	1995-01-19	1995-01-19	Pharmaceutical formulations
GB9500978.3		1995-01-19
PCT/EP1996/000302 WO1996022105A1 (fr)	1995-01-19	1996-01-17	Formulations pharmaceutiques comprenant un sel d'acide clavulanique, de la vancomycine et une ou plusieurs beta-lactamines

Publications (1)

Publication Number	Publication Date
JPH11501904A true JPH11501904A (ja)	1999-02-16

Family

ID=10768207

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP8522059A Pending JPH11501904A (ja)	1995-01-19	1996-01-17	クラブラン酸の塩、バンコマイシンおよび１種またはそれ以上のベータ−ラクタム系抗生物質を含んでなる医薬処方

Country Status (4)

Country	Link
EP (1)	EP0804220A1 (fr)
JP (1)	JPH11501904A (fr)
GB (1)	GB9500978D0 (fr)
WO (1)	WO1996022105A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008530082A (ja) *	2005-02-14	2008-08-07	ヴィーナス・レメディーズ・リミテッド	薬剤耐性菌による感染性病状のための非経口的併用療法

1995
- 1995-01-19 GB GBGB9500978.3A patent/GB9500978D0/en active Pending
1996
- 1996-01-17 WO PCT/EP1996/000302 patent/WO1996022105A1/fr not_active Ceased
- 1996-01-17 EP EP96901332A patent/EP0804220A1/fr not_active Withdrawn
- 1996-01-17 JP JP8522059A patent/JPH11501904A/ja active Pending

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2008530082A (ja) *	2005-02-14	2008-08-07	ヴィーナス・レメディーズ・リミテッド	薬剤耐性菌による感染性病状のための非経口的併用療法

Also Published As

Publication number	Publication date
GB9500978D0 (en)	1995-03-08
EP0804220A1 (fr)	1997-11-05
WO1996022105A1 (fr)	1996-07-25

Publication	Publication Date	Title
AU2011373912B2 (en)	2016-09-29	Pharmaceutical compositions comprising beta-lactam antibiotic, sulbactam and beta-lactamase inhibitor
JPH08505868A (ja)	1996-06-25	クラブラン酸のみまたは他のベータ−ラクタム抗生物質と混合されたクラブラン酸からなる薬剤処方
AU2013308128A1 (en)	2015-04-30	Antibacterial compositions
US20030109503A1 (en)	2003-06-12	Pharmaceutical formulations comprising clavulanic acid alone or in combination with other beta-lactam antibiotics
WO2001045667A2 (fr)	2001-06-28	Poudres hydrosolubles destinees a des solutions orales et leur utilisation
WO1994027600A1 (fr)	1994-12-08	Preparations pharmaceutiques a base d'acide clavulanique et d'un agent antimycobacterien
US5658887A (en)	1997-08-19	Pharmaceutical formulations comprising a clavulanic acid salt and erithromycin derivatite
EP0003618B1 (fr)	1981-01-28	Composition anti-bactérienne et son usage
CA2468036C (fr)	2008-01-22	Methode de traitement des infections bacteriennes a l'aide de gemifloxacine ou d'un sel de celle-ci et d'une .beta.-lactamine
WO1996022105A1 (fr)	1996-07-25	Formulations pharmaceutiques comprenant un sel d'acide clavulanique, de la vancomycine et une ou plusieurs beta-lactamines
AU648792B2 (en)	1994-05-05	Veterinary treatment for pigs
EP1313500B1 (fr)	2004-10-13	Associations dalfopristine/quinupristine avec le cefpirome
CA2079328C (fr)	2002-01-29	Formulation veterinaire d'amoxycilline et d'acide clavunalique et leurs derives
EA004594B1 (ru)	2004-06-24	Способ лечения устойчивой к медикаментам инфекции mycobacterium tuberculosis
IE83642B1 (en)		Veterinary treatment
EP3096778A2 (fr)	2016-11-30	Dose ultra-faible de lysostaphine pour le traitement de mrsa
CA2054440A1 (fr)	1993-01-07	Formulations pharmaceutiques
Montravers et al.	1998	Early bacterial and inflammatory responses to antibiotic therapy in a model of polymicrobial peritonitis in rats
JPS6143116A (ja)	1986-03-01	細菌性感染症の治療および治療薬
MC1350A1 (fr)	1981-06-22	Compositions ayant des proprietes antibiotiques et un procede pour la preparation de ces compositions

JPH11501904A - クラブラン酸の塩、バンコマイシンおよび１種またはそれ以上のベータ−ラクタム系抗生物質を含んでなる医薬処方 - Google Patents

Info

Links

Classifications

Landscapes

Applications Claiming Priority (3)

Publications (1)

Family

ID=10768207

Family Applications (1)

Country Status (4)

Cited By (1)

Cited By (1)

Also Published As

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