JPH11507036A5 - - Google Patents

Info

Publication number
JPH11507036A5
JPH11507036A5 JP1997500868A JP50086897A JPH11507036A5 JP H11507036 A5 JPH11507036 A5 JP H11507036A5 JP 1997500868 A JP1997500868 A JP 1997500868A JP 50086897 A JP50086897 A JP 50086897A JP H11507036 A5 JPH11507036 A5 JP H11507036A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
JP1997500868A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11507036A (ja
Filing date
Publication date
Priority claimed from US08/472,996 external-priority patent/US5643935A/en
Application filed filed Critical
Publication of JPH11507036A publication Critical patent/JPH11507036A/ja
Publication of JPH11507036A5 publication Critical patent/JPH11507036A5/ja
Ceased legal-status Critical Current

Links

JP9500868A 1995-06-07 1996-06-03 ジカチオン性ビス−ベンズイミダゾール類を用いた感染病治療方法 Ceased JPH11507036A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/472,996 US5643935A (en) 1995-06-07 1995-06-07 Method of combatting infectious diseases using dicationic bis-benzimidazoles
US08/472,996 1995-06-07
PCT/US1996/008084 WO1996040145A1 (en) 1995-06-07 1996-06-03 Methods of combatting infectious diseases using dicationic bis-benzimidazoles

Publications (2)

Publication Number Publication Date
JPH11507036A JPH11507036A (ja) 1999-06-22
JPH11507036A5 true JPH11507036A5 (2) 2004-07-22

Family

ID=23877744

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9500868A Ceased JPH11507036A (ja) 1995-06-07 1996-06-03 ジカチオン性ビス−ベンズイミダゾール類を用いた感染病治療方法

Country Status (9)

Country Link
US (11) US5643935A (2)
EP (1) EP0831832B1 (2)
JP (1) JPH11507036A (2)
AT (1) ATE256464T1 (2)
AU (1) AU705261B2 (2)
CA (1) CA2223912A1 (2)
DE (1) DE69631134T2 (2)
ES (1) ES2213775T3 (2)
WO (1) WO1996040145A1 (2)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770617A (en) * 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
US5935982A (en) * 1997-02-28 1999-08-10 The University Of North Carolina At Chapel Hill Methods of treating retroviral infection and compounds useful therefor
US6635668B1 (en) * 1998-07-22 2003-10-21 The University Of North Carolina At Chapel Hill Imidazoline receptor binding compounds
CA2344445A1 (en) * 1998-09-17 2000-03-23 The University Of North Carolina At Chapel Hill Antifungal activity of dicationic molecules
EP1685836A3 (en) * 1998-09-17 2007-05-09 University Of North Carolina At Chapel Hill Antifungal activity of dicationic molecules
EP1165096B1 (en) * 1999-03-29 2009-09-09 Shire Canada Inc. Use of cytidine derivatives for the treatment of leukaemia
DK1231910T3 (da) * 1999-11-16 2009-08-31 Oncozyme Pharma Inc Pentamidin til behandling af cancer
US7115665B1 (en) 2000-11-16 2006-10-03 Onocozyme Pharma, Inc. Inhibitors of endo-exonuclease activity for treating cancer
US7156809B2 (en) 1999-12-17 2007-01-02 Q-Tec Systems Llc Method and apparatus for health and disease management combining patient data monitoring with wireless internet connectivity
US6677377B2 (en) * 2000-06-21 2004-01-13 Georgetown University School Of Medicine Structure based discovery of inhibitors of matriptase for the treatment of cancer and other conditions
US6569853B1 (en) * 2000-11-06 2003-05-27 Combinatorx, Incorporated Combinations of chlorpromazine and pentamidine for the treatment of neoplastic disorders
US6706754B2 (en) * 2000-11-06 2004-03-16 The United States Of America As Represented By The Secretary Of The Army Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis
MXPA04001153A (es) * 2001-08-31 2005-02-17 Neurochem Int Ltd Derivados de amidina para tratar la amiloidosis.
AU2003302218A1 (en) 2002-05-16 2004-06-18 Genelabs Technologies, Inc Aryl and heteroaryl compounds as antibacterial and antifungal agents
MXPA04012628A (es) * 2002-06-13 2005-03-23 Patricia Olivershaffer DERIVADOS Y COMPUESTOS RELACIONADOS DEL áCIDO 2-UREIDO-6-HETEROARIL-3H-BENZOIMIDAZOL-4-CARBOXILICO COMO INHIBIDORES DE GIRASA Y/O TOPOISOMERASA IV PARA EL TRATAMIENTO DE INFECCIONES BACTERIALES.
US7582641B2 (en) * 2003-01-31 2009-09-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
AR042956A1 (es) * 2003-01-31 2005-07-13 Vertex Pharma Inhibidores de girasa y usos de los mismos
US7618974B2 (en) * 2003-01-31 2009-11-17 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8404852B2 (en) 2003-01-31 2013-03-26 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US7569591B2 (en) * 2003-01-31 2009-08-04 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US8193352B2 (en) * 2003-01-31 2012-06-05 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US20050054708A1 (en) * 2003-07-28 2005-03-10 Nichols Matthew James Combinations of drugs for the treatment of neoplasms
US20050080075A1 (en) * 2003-08-25 2005-04-14 Nichols M. James Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
US20050100508A1 (en) * 2003-11-12 2005-05-12 Nichols M. J. Methods for identifying drug combinations for the treatment of proliferative diseases
US20050158320A1 (en) * 2003-11-12 2005-07-21 Nichols M. J. Combinations for the treatment of proliferative diseases
US7262223B2 (en) * 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
WO2005089370A2 (en) 2004-03-16 2005-09-29 Goodis Charles J Endodontic files and obturator devices and methods of manufacturing same
US7459457B2 (en) 2004-04-13 2008-12-02 Icagen, Inc. Polycyclic pyridines as potassium ion channel modulators
DE102004031656A1 (de) * 2004-06-30 2006-01-19 Merck Patent Gmbh Tetrahydrochinoline
US7817792B2 (en) * 2006-05-04 2010-10-19 Microsoft Corporation Hyperlink-based softphone call and management
DE102007013856A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydropyrrolochinoline
DE102007013854A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Tetrahydrochinoline
DE102007013855A1 (de) 2007-03-20 2008-09-25 Merck Patent Gmbh Substituierte Tetrahydrochinoline
EP2194981B1 (en) * 2007-10-05 2011-11-23 Université de Mons-Hainaut Bisbenzimidazoles as antimalarial agents
US8748618B2 (en) 2009-05-13 2014-06-10 University Of Virginia Patent Foundation Inhibitors of inv(16) leukemia
RU2625305C2 (ru) 2011-01-14 2017-07-13 Сперо Тринем, Инк. Твердые формы ингибитора гиразы (r)-1-этил-3-[6-фтор-5[2-(1-гидрокси-1-метил-этил) пиримидин-5-ил]-7-(тетрагидрофуран-2-ил)-1н-бензимидазол-2-ил] мочевины
JP6085829B2 (ja) 2011-01-14 2017-03-01 スペロ トリネム, インコーポレイテッド ピリミジンジャイレースおよびトポイソメラーゼiv阻害剤
PT2663556E (pt) 2011-01-14 2014-11-27 Vertex Pharma Processo de fabrico de inibidores de girase e topoisomerase iv
EP2663558A1 (en) 2011-01-14 2013-11-20 Vertex Pharmaceuticals Incorporated Solid forms of gyrase inhibitor (r)-1-ethyl-3-[5-[2-{1-hydroxy-1-methyl-ethyl}pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl}-1h-benzimidazol-2-yl]urea
WO2012177707A1 (en) 2011-06-20 2012-12-27 Vertex Pharmaceuticals Incorporated Phosphate esters of gyrase and topoisomerase inhibitors
US9018216B2 (en) 2012-07-18 2015-04-28 Vertex Pharmaceuticals Incorporated Solid forms of (R)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1H-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
WO2014014845A1 (en) 2012-07-18 2014-01-23 Vertex Pharmaceuticals Incorporated Combination therapy comprising|1 -ethyl-3-[5-[2-{1 -hydroxy-1 -methyl-ethyl}pyrimidin-5-yl]-7-(tetra hydrofuran-2-|yl}-1 h-benzimidazol-2-yl]urea and derivatives thereof to treat mycobacterium|diseases
GB201506658D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
GB201506660D0 (en) 2015-04-20 2015-06-03 Cellcentric Ltd Pharmaceutical compounds
HK1248235A1 (zh) * 2015-05-15 2018-10-12 吉利德科学公司 具有作为吲哚胺2,3-二加氧酶抑制剂活性的苯并咪唑和咪唑并吡啶亚氨代甲酰胺化合物
EA201990395A1 (ru) 2016-07-27 2019-07-31 Юниверсити Оф Вирджиния Пэйтент Фаундейшн Варианты комбинированной терапии для лечения рака
US20200030295A1 (en) * 2016-08-02 2020-01-30 Friedrich-Alexander-Universität Erlangen-Nürnberg Heterocyclic diamidines

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1542284A (en) * 1976-01-09 1979-03-14 Barcrest Ltd Recording electrical information
ES467739A1 (es) * 1977-03-16 1979-07-01 Hoechst Ag Procedimiento para la preparacion de compuestos de bisbenci-midazolil sustituidos
DE2839989A1 (de) * 1978-09-14 1980-04-03 Hoechst Ag Substituierte bisbenzimidazolylverbindungen, ihre herstellung und ihre verwendung
US4963589A (en) * 1988-10-25 1990-10-16 The University Of North Carolina At Chapel Hill Methods for treating Giardia lamblia
US4933347A (en) * 1988-10-25 1990-06-12 University Of North Carolina At Chapel Hill Diamidines and bis(imidazolines) for the treatment of and prophylaxis against pneumocystis carinii pneumonia
US5134152A (en) * 1989-12-07 1992-07-28 Sankyo Company, Limited Oxetane derivatives and their use as anti-fungal or fungicidal agents
FR2674246B1 (fr) * 1991-03-21 1993-07-09 Roussel Uclaf Nouveaux derives de l'acide alpha-methylene 5-thiazolacetique, leur procede de preparation et les intermediaires de ce procede, leur application a titre de fongicides et les compositions les renfermant.
EP0508527A1 (en) * 1991-04-11 1992-10-14 UNIROYAL CHEMICAL COMPANY, Inc. New fungicidally active pyrazole compounds
US5362910A (en) * 1991-10-08 1994-11-08 Nicca Chemical Co., Ltd. Germicidal and fungicidal agent and a germicidal and fungicidal method
JPH05140114A (ja) * 1991-11-22 1993-06-08 Otsuka Chem Co Ltd アゾール−1−カルボン酸エステル誘導体及び殺菌剤
US5428051A (en) * 1992-10-13 1995-06-27 University Of North Carolina Methods of combating pneumocystis carinii pneumonia and compounds useful therefor
US5667975A (en) * 1994-05-06 1997-09-16 The University Of North Carolina Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans

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