|
ATE194384T1
(de)
|
1989-09-12 |
2000-07-15 |
Hoffmann La Roche |
Tnf-bindende proteine
|
|
US5705364A
(en)
†
|
1995-06-06 |
1998-01-06 |
Genentech, Inc. |
Mammalian cell culture process
|
|
US6656466B1
(en)
*
|
1995-06-06 |
2003-12-02 |
Genetech, Inc. |
Human tumor necrosis factor—immunoglobulin(TNFR1-IgG1) chimera composition
|
|
JP4306813B2
(ja)
|
1995-09-19 |
2009-08-05 |
アスビオファーマ株式会社 |
動物細胞の新規培養方法
|
|
TR199802238T2
(xx)
*
|
1996-05-08 |
1999-02-22 |
F. Hoffmann-La Roche Ag |
Astımın TNFR-Ig ile tedavisi.
|
|
ES2252876T5
(es)
*
|
1997-12-03 |
2014-04-03 |
Roche Diagnostics Gmbh |
Proceso para preparar polipéptidos con glicolización adecuada
|
|
US6140445A
(en)
*
|
1998-04-17 |
2000-10-31 |
Crompton Corporation |
Silane functional oligomer
|
|
US6528286B1
(en)
*
|
1998-05-29 |
2003-03-04 |
Genentech, Inc. |
Mammalian cell culture process for producing glycoproteins
|
|
EP1092037B1
(en)
*
|
1998-05-29 |
2005-12-28 |
Genentech, Inc. |
Cell culture process for producing glycoproteins
|
|
TR200504220T2
(tr)
|
1998-12-17 |
2007-04-24 |
Biogen Idec Ma Inc. |
Aktif limfotoksin-beta reseptör imunoglobülin şimeAktif limfotoksin-beta reseptör imunoglobülin şimerik proteinlerinin yüksek düzey ifadesi ve saflaştrik proteinlerinin yüksek düzey ifadesi ve saflaştırılması için bir yöntem.ırılması için bir yöntem.
|
|
GB9828624D0
(en)
*
|
1998-12-23 |
1999-02-17 |
Glaxo Group Ltd |
Production of proteins
|
|
KR100475417B1
(ko)
*
|
1998-12-30 |
2005-07-18 |
씨제이 주식회사 |
시알산 함량이 높은 재조합 당단백질의 제조방법
|
|
US7294481B1
(en)
|
1999-01-05 |
2007-11-13 |
Immunex Corporation |
Method for producing recombinant proteins
|
|
IL145893A0
(en)
|
1999-04-26 |
2002-07-25 |
Genentech Inc |
Cell culture process for glycoproteins
|
|
US6261805B1
(en)
*
|
1999-07-15 |
2001-07-17 |
Boyce Thompson Institute For Plant Research, Inc. |
Sialyiation of N-linked glycoproteins in the baculovirus expression vector system
|
|
KR100394474B1
(ko)
*
|
1999-12-18 |
2003-08-09 |
동아제약 주식회사 |
동물세포에서 재조합 당단백질의 연속식 대량생산 방법
|
|
AU2001258536A1
(en)
|
2000-05-16 |
2001-11-26 |
Lipoxen Technologies Limited |
Derivatisation of proteins in aqueous solution
|
|
AU2001271021A1
(en)
*
|
2000-07-05 |
2002-01-14 |
Japan As Represented By Secretary Of Osaka University |
Process for producing glycoprotein
|
|
US20030040095A1
(en)
*
|
2001-03-16 |
2003-02-27 |
Achille Arini |
Method for the production of pharmaceutically active recombinant proteins
|
|
AU2002316230A1
(en)
*
|
2001-06-13 |
2002-12-23 |
Genentech, Inc. |
Methods of culturing animal cells and polypeptide production in animal cells
|
|
US6872549B2
(en)
*
|
2002-03-27 |
2005-03-29 |
Immunex Corporation |
Methods for increasing polypeptide production
|
|
US20030190710A1
(en)
*
|
2002-03-28 |
2003-10-09 |
Devries Ruth L. |
Control of glycoforms in IgG
|
|
US6924124B1
(en)
*
|
2002-08-23 |
2005-08-02 |
Immunex Corporation |
Feeding strategies for cell culture
|
|
US7067279B1
(en)
*
|
2002-08-23 |
2006-06-27 |
Immunex Corporation |
Cell culture performance with betaine
|
|
US6974681B1
(en)
|
2002-08-23 |
2005-12-13 |
Immunex Corporation |
Cell culture performance with vanadate
|
|
DE60333228D1
(de)
*
|
2002-12-02 |
2010-08-12 |
Amgen Fremont Inc |
Gegen den tumor nekrose faktor gerichtete antikörper und deren verwendungen
|
|
CN101857851A
(zh)
*
|
2002-12-23 |
2010-10-13 |
布里斯托尔-迈尔斯斯奎布公司 |
用于蛋白质生产的哺乳动物细胞培养方法
|
|
DE60335024D1
(de)
*
|
2002-12-23 |
2010-12-30 |
Bristol Myers Squibb Co |
Produktqualitätsverbesserung in säugerzellkulturverfahrenzur proteinproduktion
|
|
US20040265964A1
(en)
*
|
2003-04-25 |
2004-12-30 |
Martin Allen |
Inducers of recombinant protein expression
|
|
WO2005040377A2
(en)
|
2003-10-24 |
2005-05-06 |
Selexis S.A. |
High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences
|
|
EP1697414A2
(en)
*
|
2003-12-23 |
2006-09-06 |
Applied Research Systems ARS Holding N.V. |
Process for the production of tumor necrosis factor-binding proteins
|
|
WO2005064002A1
(en)
*
|
2003-12-31 |
2005-07-14 |
Samyang Genex Corporation |
Method for mass production of secondary metabolites in plant cell culture by treatment of an alkanoic acid or salt thereof
|
|
EP1725673A1
(en)
*
|
2004-02-13 |
2006-11-29 |
Glycotope Gmbh |
Sialytated glycoproteins-process conditions and an efficient method for their production
|
|
TWI374935B
(en)
*
|
2004-08-27 |
2012-10-21 |
Pfizer Ireland Pharmaceuticals |
Production of α-abeta
|
|
TWI364458B
(en)
*
|
2004-08-27 |
2012-05-21 |
Wyeth Res Ireland Ltd |
Production of tnfr-lg
|
|
TWI384069B
(zh)
*
|
2004-08-27 |
2013-02-01 |
Pfizer Ireland Pharmaceuticals |
多胜肽之製法
|
|
AU2006247039B2
(en)
*
|
2005-05-19 |
2011-03-03 |
Amgen Inc. |
Compositions and methods for increasing the stability of antibodies
|
|
JP2008541746A
(ja)
*
|
2005-06-03 |
2008-11-27 |
ビオヴィトルム・アクチボラゲット（プブリクト） |
新規プロセス
|
|
KR100670105B1
(ko)
|
2005-06-29 |
2007-01-17 |
주식회사 셀트리온 |
콩가수분해물의 저분자량 분획을 이용하여 시알산 함량이증가된 에리스로포이에틴을 생산하는 방법 및 그에 의하여생산된 시알산 함량이 증가된 에리스로포이에틴
|
|
US8470318B2
(en)
|
2005-11-07 |
2013-06-25 |
The Rockefeller University |
Polypeptides with enhanced anti-inflammatory and decreased cytotoxic properties and relating methods
|
|
EP2253644B1
(en)
|
2005-12-20 |
2013-10-16 |
Bristol-Myers Squibb Company |
Compositions and methods for producing a composition
|
|
AR058568A1
(es)
|
2005-12-20 |
2008-02-13 |
Bristol Myers Squibb Co |
Metodos para producir una composicion con moleculas ctla4-ig a partir de un medio de cultivo
|
|
US20070190057A1
(en)
|
2006-01-23 |
2007-08-16 |
Jian Wu |
Methods for modulating mannose content of recombinant proteins
|
|
EP2264060B1
(en)
*
|
2006-01-26 |
2014-04-23 |
Recopharma AB |
Compositions and methods for inhibiting viral adhesion
|
|
MX2008012843A
(es)
*
|
2006-04-05 |
2009-01-19 |
Univ Rockefeller |
Polipeptidos con propiedades antiinflamatorias aumentadas y citotoxicas reducidas y metodos relacionados.
|
|
DK2041270T3
(da)
|
2006-07-13 |
2014-01-27 |
Wyeth Llc |
Fremstilling af glycoproteiner
|
|
TWI456062B
(zh)
*
|
2006-09-13 |
2014-10-11 |
Abbvie Inc |
細胞培養改良
|
|
US8911964B2
(en)
|
2006-09-13 |
2014-12-16 |
Abbvie Inc. |
Fed-batch method of making human anti-TNF-alpha antibody
|
|
US20080145893A1
(en)
*
|
2006-09-17 |
2008-06-19 |
Excellegene Sa |
Method for producing a recombinant protein at high specific productivity, high batch yield and high volumetric yield by means of transient transfection
|
|
EP2091969A4
(en)
*
|
2006-10-27 |
2010-05-12 |
Univ Rockefeller |
POLYPEPTIDES WITH IMPROVED INFLAMMATORY INHIBITION AND REDUCED CYTOTOXIC PROPERTIES AND RELATED METHODS THEREFOR
|
|
WO2008069244A1
(ja)
*
|
2006-12-05 |
2008-06-12 |
Kyowa Hakko Kogyo Co., Ltd. |
糖蛋白質組成物の製造方法
|
|
US8338088B2
(en)
*
|
2007-04-16 |
2012-12-25 |
Momenta Pharmaceuticals, Inc. |
Methods related to cell surface glycosylation
|
|
TW200902708A
(en)
|
2007-04-23 |
2009-01-16 |
Wyeth Corp |
Methods of protein production using anti-senescence compounds
|
|
US20090023186A1
(en)
*
|
2007-07-22 |
2009-01-22 |
Excellgene Sa |
Use of valproic acid for enhancing production of recombinant proteins in mammalian cells
|
|
WO2009023562A2
(en)
*
|
2007-08-09 |
2009-02-19 |
Wyeth |
Use of perfusion to enhance production of fed-batch cell culture in bioreactors
|
|
KR20140130512A
(ko)
*
|
2008-03-06 |
2014-11-10 |
할로자임, 아이엔씨 |
가용성 히알루로니다아제의 대규모 제조
|
|
TWI395593B
(zh)
|
2008-03-06 |
2013-05-11 |
Halozyme Inc |
可活化的基質降解酵素之活體內暫時性控制
|
|
JP5628790B2
(ja)
|
2008-04-07 |
2014-11-19 |
バイエル・ヘルスケア・エルエルシー |
糖タンパク質の組換え生産の方法
|
|
WO2009132130A2
(en)
|
2008-04-22 |
2009-10-29 |
The Rockefeller University |
Methods of identifying anti-inflammatory compounds
|
|
HRP20180738T1
(hr)
|
2008-09-15 |
2018-06-15 |
F. Hoffmann - La Roche Ag |
Pripravci i postupci za regulaciju stanične osmolarnosti
|
|
MX2011004201A
(es)
|
2008-10-20 |
2011-05-24 |
Abbott Lab |
Desactivacion viral durante purificacion de anticuerpos.
|
|
AU2009347206C1
(en)
|
2008-10-20 |
2016-12-08 |
Abbvie Inc. |
Isolation and purification of antibodies using Protein A affinity chromatography
|
|
CN103205407B
(zh)
|
2008-12-09 |
2016-03-16 |
哈洛齐梅公司 |
延长的可溶性ph20多肽及其用途
|
|
EP2403523A1
(en)
*
|
2009-03-06 |
2012-01-11 |
Halozyme, Inc. |
Temperature sensitive mutants of matrix metalloprotease 1 und uses thereof
|
|
US9540426B2
(en)
|
2009-10-06 |
2017-01-10 |
Bristol-Myers Squibb Company |
Mammalian cell culture processes for protein production
|
|
WO2011051231A1
(en)
|
2009-10-26 |
2011-05-05 |
F. Hoffmann-La Roche Ag |
Method for the production of a glycosylated immunoglobulin
|
|
ES2642629T3
(es)
|
2009-11-17 |
2017-11-17 |
E. R. Squibb & Sons, L.L.C. |
Métodos para la producción mejorada de proteínas
|
|
JP2013512674A
(ja)
*
|
2009-12-02 |
2013-04-18 |
アクセルロン ファーマ， インコーポレイテッド |
Ｆｃ融合タンパク質の血清半減期を増加させるための組成物および方法
|
|
DK2538968T3
(en)
*
|
2010-02-24 |
2017-12-11 |
Chiesi Farm Spa |
PROCEDURE FOR THE PREPARATION AND PURIFICATION OF RECOMBINANT LYSOSOMAL ALFA MANNOSIDASE
|
|
JPWO2012017925A1
(ja)
|
2010-08-02 |
2013-10-03 |
協和発酵キリン株式会社 |
物質の製造方法
|
|
CA2829774C
(en)
|
2011-03-14 |
2019-09-24 |
National Research Council Of Canada |
Method of viral production in cells
|
|
EP2702077A2
(en)
|
2011-04-27 |
2014-03-05 |
AbbVie Inc. |
Methods for controlling the galactosylation profile of recombinantly-expressed proteins
|
|
PL2702164T3
(pl)
|
2011-04-29 |
2016-06-30 |
Biocon Res Limited |
Sposób obniżania heterogeniczności przeciwciał i sposób ich wytwarzania
|
|
EP2718328A4
(en)
|
2011-06-08 |
2014-12-24 |
Acceleron Pharma Inc |
COMPOSITIONS AND METHODS FOR INCREASING THE HALF TIME OF SERUM
|
|
WO2013158273A1
(en)
|
2012-04-20 |
2013-10-24 |
Abbvie Inc. |
Methods to modulate c-terminal lysine variant distribution
|
|
US9150645B2
(en)
|
2012-04-20 |
2015-10-06 |
Abbvie, Inc. |
Cell culture methods to reduce acidic species
|
|
US9067990B2
(en)
|
2013-03-14 |
2015-06-30 |
Abbvie, Inc. |
Protein purification using displacement chromatography
|
|
US9249182B2
(en)
|
2012-05-24 |
2016-02-02 |
Abbvie, Inc. |
Purification of antibodies using hydrophobic interaction chromatography
|
|
CN102839157A
(zh)
*
|
2012-07-12 |
2012-12-26 |
扬州大学 |
稳定共表达hST3GalIV和β1-4GalT1的MDCK细胞系及构建方法和应用
|
|
HK1211981A1
(en)
|
2012-09-02 |
2016-06-03 |
Abbvie Inc. |
Methods to control protein heterogeneity
|
|
US9512214B2
(en)
|
2012-09-02 |
2016-12-06 |
Abbvie, Inc. |
Methods to control protein heterogeneity
|
|
NO2760138T3
(2)
|
2012-10-01 |
2018-08-04 |
|
|
|
US20140106405A1
(en)
*
|
2012-10-15 |
2014-04-17 |
Bristol-Myers Squibb Company |
Mammalian cell culture processes for protein production
|
|
EP2906683B1
(en)
|
2012-10-15 |
2017-05-31 |
Bristol-Myers Squibb Company |
Mammalian cell culture processes for protein production
|
|
SG11201507230PA
(en)
|
2013-03-12 |
2015-10-29 |
Abbvie Inc |
Human antibodies that bind human tnf-alpha and methods of preparing the same
|
|
US8921526B2
(en)
|
2013-03-14 |
2014-12-30 |
Abbvie, Inc. |
Mutated anti-TNFα antibodies and methods of their use
|
|
US9217168B2
(en)
|
2013-03-14 |
2015-12-22 |
Momenta Pharmaceuticals, Inc. |
Methods of cell culture
|
|
WO2014151878A2
(en)
|
2013-03-14 |
2014-09-25 |
Abbvie Inc. |
Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosacharides
|
|
US9017687B1
(en)
|
2013-10-18 |
2015-04-28 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same using displacement chromatography
|
|
AR095196A1
(es)
|
2013-03-15 |
2015-09-30 |
Regeneron Pharma |
Medio de cultivo celular libre de suero
|
|
CN105378480B
(zh)
|
2013-07-04 |
2018-06-12 |
豪夫迈·罗氏有限公司 |
检测血清样品中抗药物抗体的干扰抑制性免疫测定
|
|
TW201514305A
(zh)
|
2013-07-06 |
2015-04-16 |
Cadila Healthcare Ltd |
製造單株抗體之改良方法
|
|
US9598667B2
(en)
|
2013-10-04 |
2017-03-21 |
Abbvie Inc. |
Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins
|
|
US9085618B2
(en)
|
2013-10-18 |
2015-07-21 |
Abbvie, Inc. |
Low acidic species compositions and methods for producing and using the same
|
|
US8946395B1
(en)
|
2013-10-18 |
2015-02-03 |
Abbvie Inc. |
Purification of proteins using hydrophobic interaction chromatography
|
|
US9181337B2
(en)
|
2013-10-18 |
2015-11-10 |
Abbvie, Inc. |
Modulated lysine variant species compositions and methods for producing and using the same
|
|
US20150139988A1
(en)
|
2013-11-15 |
2015-05-21 |
Abbvie, Inc. |
Glycoengineered binding protein compositions
|
|
HRP20200100T1
(hr)
*
|
2014-02-27 |
2020-04-03 |
F. Hoffmann - La Roche Ag |
Modulacija rasta i glikozilacije stanica u rekombinantnoj proizvodnji glikoproteina
|
|
JP6652334B2
(ja)
|
2014-05-31 |
2020-02-19 |
Ｊｃｒファーマ株式会社 |
ウリジンとｎ−アセチル−ｄ−マンノサミンとを含有する培地
|
|
JP2017516484A
(ja)
*
|
2014-06-03 |
2017-06-22 |
ルピン・リミテッド |
タンパク質生産のための細胞培養工程
|
|
US20160130324A1
(en)
|
2014-10-31 |
2016-05-12 |
Shire Human Genetic Therapies, Inc. |
C1 Inhibitor Fusion Proteins and Uses Thereof
|
|
KR102007930B1
(ko)
|
2014-12-31 |
2019-08-06 |
주식회사 엘지화학 |
재조합 당단백질의 글리코실화 조절 방법
|
|
TW202440904A
(zh)
|
2015-08-04 |
2024-10-16 |
美商再生元醫藥公司 |
補充牛磺酸之細胞培養基及用法（二）
|
|
CA3005906A1
(en)
|
2015-11-19 |
2017-05-26 |
Shire Human Genetic Therapies, Inc. |
Recombinant human c1 esterase inhibitor and uses thereof
|
|
EP3397076A1
(en)
*
|
2015-12-29 |
2018-11-07 |
N.V. Nutricia |
Fermented formula with non-digestible oligosaccharides
|
|
EP3717656B1
(en)
*
|
2017-11-30 |
2024-03-13 |
F. Hoffmann-La Roche AG |
Process for culturing mammalian cells
|
|
EA202191352A1
(ru)
|
2018-11-13 |
2021-08-11 |
Янссен Байотек, Инк. |
Контроль содержания микроэлементов-металлов во время продукции антител к cd38
|
|
US12297451B1
(en)
|
2019-10-25 |
2025-05-13 |
Regeneron Pharmaceuticals, Inc. |
Cell culture medium
|
|
US11180540B2
(en)
|
2019-12-06 |
2021-11-23 |
Regeneron Pharmaceuticals, Inc. |
Anti-VEGF protein compositions and methods for producing the same
|
|
JP2023525034A
(ja)
|
2020-05-08 |
2023-06-14 |
リジェネロン・ファーマシューティカルズ・インコーポレイテッド |
Ｖｅｇｆトラップおよびミニトラップならびに眼障害およびがんの治療方法
|
|
AU2021332355A1
(en)
|
2020-08-31 |
2023-03-23 |
Regeneron Pharmaceuticals, Inc. |
Asparagine feed strategies to improve cell culture performance and mitigate asparagine sequence variants
|
|
KR20230134117A
(ko)
|
2021-01-20 |
2023-09-20 |
리제너론 파마슈티칼스 인코포레이티드 |
세포 배양물에서 단백질 역가를 개선시키는 방법
|
|
WO2023059800A2
(en)
|
2021-10-07 |
2023-04-13 |
Regeneron Pharmaceuticals, Inc. |
Systems and methods of ph modeling and control
|
|
CA3230985A1
(en)
|
2021-10-07 |
2023-04-13 |
Ross BROWNE |
Ph meter calibration and correction
|
|
WO2023167847A2
(en)
|
2022-03-02 |
2023-09-07 |
Regeneron Pharmaceuticals, Inc. |
Bioreactor for antibody production
|
|
WO2025219232A1
(en)
|
2024-04-15 |
2025-10-23 |
Evonik Operations Gmbh |
Application of small peptides supplemented cell culture media for improved cell performance
|