JPH11508134A - 肥満症蛋白質中間体およびその製法と使用 - Google Patents

肥満症蛋白質中間体およびその製法と使用

Info

Publication number
JPH11508134A
JPH11508134A JP9503935A JP50393597A JPH11508134A JP H11508134 A JPH11508134 A JP H11508134A JP 9503935 A JP9503935 A JP 9503935A JP 50393597 A JP50393597 A JP 50393597A JP H11508134 A JPH11508134 A JP H11508134A
Authority
JP
Japan
Prior art keywords
protein
glu
ser
replaced
gly
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9503935A
Other languages
English (en)
Japanese (ja)
Inventor
ヘイル，ジョン・エドワード
マッケラー，ウォーレン・キャメロン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPH11508134A publication Critical patent/JPH11508134A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J3/00—Working-up of proteins for foodstuffs
    • A23J3/30—Working-up of proteins for foodstuffs by hydrolysis
    • A23J3/32—Working-up of proteins for foodstuffs by hydrolysis using chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Obesity (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP9503935A 1995-06-22 1996-06-20 肥満症蛋白質中間体およびその製法と使用 Pending JPH11508134A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US45195P 1995-06-22 1995-06-22
US60/000,451 1995-06-22
PCT/US1996/010613 WO1997000886A1 (fr) 1995-06-22 1996-06-20 Intermediaires de proteines contre l'obesite, leur preparation et leur utilisation

Publications (1)

Publication Number Publication Date
JPH11508134A true JPH11508134A (ja) 1999-07-21

Family

ID=21691591

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9503935A Pending JPH11508134A (ja) 1995-06-22 1996-06-20 肥満症蛋白質中間体およびその製法と使用

Country Status (5)

Country Link
EP (1) EP0833835A4 (fr)
JP (1) JPH11508134A (fr)
AU (1) AU6284896A (fr)
CA (1) CA2224867A1 (fr)
WO (1) WO1997000886A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2217698A1 (fr) * 1996-12-20 1998-06-20 Eli Lilly And Company Proteines contre l'obesite
US6420339B1 (en) 1998-10-14 2002-07-16 Amgen Inc. Site-directed dual pegylation of proteins for improved bioactivity and biocompatibility
DE10059336A1 (de) * 2000-11-29 2002-06-13 Scil Proteins Gmbh Herstellung von rekombinantem BMP-2
AU2002359288B2 (en) 2001-10-22 2008-07-31 Amgen, Inc. Use of leptin for treating human lipoatrophy and method of determining predisposition to said treatment
EP2416797A4 (fr) 2009-04-10 2013-04-24 Amylin Pharmaceuticals Llc Composés agonistes de l'amyline pour mammifères ayant une carence en strogènes
PT2621515T (pt) 2010-09-28 2017-07-12 Aegerion Pharmaceuticals Inc Polipéptido quimérico de leptina de foca-ser humano com solubilidade aumentada

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU674568B2 (en) * 1993-02-04 1997-01-02 Anaphore, Inc. Improved method for the refolding of proteins
US6309853B1 (en) * 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US5594101A (en) * 1995-03-03 1997-01-14 Eli Lilly And Company Anti-obesity proteins
GB9509164D0 (en) * 1995-05-05 1995-06-28 Smithkline Beecham Plc Novel compounds
ATE259650T1 (de) * 1995-08-17 2004-03-15 Amgen Inc Verfahren zur verringerung und zur erhaltung von verringerten blutspiegeln von lipiden mittels zubereitungen von ob-proteinen

Also Published As

Publication number Publication date
EP0833835A4 (fr) 1999-05-26
EP0833835A1 (fr) 1998-04-08
CA2224867A1 (fr) 1997-01-09
WO1997000886A1 (fr) 1997-01-09
AU6284896A (en) 1997-01-22

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