JPH11511113A5 - - Google Patents

Info

Publication number
JPH11511113A5
JPH11511113A5 JP1996531337A JP53133796A JPH11511113A5 JP H11511113 A5 JPH11511113 A5 JP H11511113A5 JP 1996531337 A JP1996531337 A JP 1996531337A JP 53133796 A JP53133796 A JP 53133796A JP H11511113 A5 JPH11511113 A5 JP H11511113A5
Authority
JP
Japan
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP1996531337A
Other languages
English (en)
Japanese (ja)
Other versions
JPH11511113A (ja
Filing date
Publication date
Priority claimed from GBGB9516943.9A external-priority patent/GB9516943D0/en
Application filed filed Critical
Publication of JPH11511113A publication Critical patent/JPH11511113A/ja
Publication of JPH11511113A5 publication Critical patent/JPH11511113A5/ja
Withdrawn legal-status Critical Current

Links

JP8531337A 1995-08-18 1996-08-19 シクロプロピルインドール類およびそのセコ前駆体、ならびにプロドラッグとしてのこれらの使用 Withdrawn JPH11511113A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9516943.9A GB9516943D0 (en) 1995-08-18 1995-08-18 Novel cyclopropylindoles and their secoprecursors,and their use as prodrugs
GB9516943.9 1995-08-18
PCT/NZ1996/000083 WO1997007097A1 (en) 1995-08-18 1996-08-19 Cyclopropylindoles and their seco precursors, and their use as prodrugs

Publications (2)

Publication Number Publication Date
JPH11511113A JPH11511113A (ja) 1999-09-28
JPH11511113A5 true JPH11511113A5 (2) 2004-07-22

Family

ID=10779431

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8531337A Withdrawn JPH11511113A (ja) 1995-08-18 1996-08-19 シクロプロピルインドール類およびそのセコ前駆体、ならびにプロドラッグとしてのこれらの使用

Country Status (8)

Country Link
US (1) US5985909A (2)
EP (1) EP0850220A1 (2)
JP (1) JPH11511113A (2)
AU (1) AU707644B2 (2)
CA (1) CA2229264A1 (2)
GB (1) GB9516943D0 (2)
NZ (1) NZ315410A (2)
WO (1) WO1997007097A1 (2)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ334344A (en) * 1996-09-12 2000-08-25 Cancer Res Campaign Tech benzo[e]indole and pyrrolo[3,2-e]indole compounds and their use as prodrugs
US6130237A (en) * 1996-09-12 2000-10-10 Cancer Research Campaign Technology Limited Condensed N-aclyindoles as antitumor agents
GB9712370D0 (en) 1997-06-14 1997-08-13 Aepact Ltd Therapeutic systems
EP0887348A1 (en) * 1997-06-25 1998-12-30 Boehringer Mannheim Italia S.p.A. Bis-Indole derivatives having antimetastatic activity, a process for their preparation and pharmaceutical compositions containing them
US6410584B1 (en) * 1998-01-14 2002-06-25 Cell Pathways, Inc. Method for inhibiting neoplastic cells with indole derivatives
GB9818730D0 (en) 1998-08-27 1998-10-21 Univ Portsmouth Collections of compounds
DE69930328T2 (de) 1998-08-27 2006-12-14 Spirogen Ltd., Ryde Dimere Pyrrolobenzodiazepine
US6909006B1 (en) * 1999-08-27 2005-06-21 Spirogen Limited Cyclopropylindole derivatives
EP2357009A1 (en) 2002-07-15 2011-08-17 Board of Regents, The University of Texas System Duramycin peptide binding to anionic phospholipids and aminophospholipids conjugates and their use in treating viral infections
GB0226593D0 (en) 2002-11-14 2002-12-24 Consultants Ltd Compounds
ZA200507752B (en) * 2003-03-28 2007-01-31 Threshold Pharmaceuticals Inc Compositions and methods for treating cancer
GB0321295D0 (en) 2003-09-11 2003-10-15 Spirogen Ltd Synthesis of protected pyrrolobenzodiazepines
CN102746336B (zh) 2005-06-29 2015-08-19 施瑞修德制药公司 氨基磷酸酯烷化剂前体药物
EP1994000B1 (en) * 2006-02-02 2017-08-23 Syntarga B.V. Water-soluble cc-1065 analogs and their conjugates
GB0619325D0 (en) * 2006-09-30 2006-11-08 Univ Strathclyde New compounds
EP2114157B1 (en) * 2006-12-26 2021-05-26 ImmunoGenesis, Inc. Phosphoramidate alkylator prodrug for the treatment of cancer
US9901567B2 (en) 2007-08-01 2018-02-27 Syntarga B.V. Substituted CC-1065 analogs and their conjugates
US20090118031A1 (en) * 2007-11-01 2009-05-07 Qualizza Gregory K Shaft Structure with Configurable Bending Profile
ES2572356T3 (es) 2007-11-09 2016-05-31 Peregrine Pharmaceuticals Inc Composiciones de anticuerpos dirigidos contra VEGF y procedimientos
UY31506A1 (es) * 2007-12-03 2009-08-03 Derivados de indolinona y procedimiento para su preparacion
AU2009320481C1 (en) 2008-11-03 2016-12-08 Syntarga B.V. Novel CC-1065 analogs and their conjugates
AU2011243294C1 (en) 2010-04-21 2015-12-03 Syntarga B.V. Novel conjugates of CC-1065 analogs and bifunctional linkers
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
EP2970269B1 (en) 2013-03-14 2017-04-19 Novartis AG 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases
EP3089963A1 (en) 2013-10-30 2016-11-09 Novartis AG 2-benzyl-benzimidazole complement factor b inhibitors and uses thereof
AU2015205574B2 (en) 2014-01-10 2019-08-15 Byondis B.V. Method for purifying Cys-linked antibody-drug conjugates
AU2022238571A1 (en) 2021-03-18 2023-09-14 Seagen Inc. Selective drug release from internalized conjugates of biologically active compounds

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0340243B1 (en) * 1986-12-19 1994-09-28 The Upjohn Company Cc-1065 analogs
GB8705477D0 (en) * 1987-03-09 1987-04-15 Carlton Med Prod Drug delivery systems
GB8919607D0 (en) * 1989-08-30 1989-10-11 Wellcome Found Novel entities for cancer therapy
AU648313B2 (en) * 1990-04-25 1994-04-21 Pharmacia & Upjohn Company Novel CC-1065 analogs
CA2122036C (en) * 1991-10-23 2002-09-17 Gillian Anlezark Bacterial nitroreductase for the reduction of cb 1954 and analogues thereof to a cytotoxic form
NZ240785A (en) * 1991-11-28 1995-08-28 Cancer Res Campaign Tech Substituted nitro aniline derivatives and medicaments
GB9314960D0 (en) * 1992-07-23 1993-09-01 Zeneca Ltd Chemical compounds
GB9323008D0 (en) * 1993-11-05 1994-01-05 Connors Thomas Improvements relating to cancer therapy

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