JPS54112876A - Preparation of 1-substituted-1,4-dihydro-4-oxo-3-quinoline carboxylic acid derivatives - Google Patents

Preparation of 1-substituted-1,4-dihydro-4-oxo-3-quinoline carboxylic acid derivatives

Info

Publication number
JPS54112876A
JPS54112876A JP1879378A JP1879378A JPS54112876A JP S54112876 A JPS54112876 A JP S54112876A JP 1879378 A JP1879378 A JP 1879378A JP 1879378 A JP1879378 A JP 1879378A JP S54112876 A JPS54112876 A JP S54112876A
Authority
JP
Japan
Prior art keywords
dihydro
oxo
substituted
preparation
carboxylic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1879378A
Other languages
Japanese (ja)
Inventor
Hideo Yasukui
Kitaro Saji
Mitsuo Nakashita
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Priority to JP1879378A priority Critical patent/JPS54112876A/en
Publication of JPS54112876A publication Critical patent/JPS54112876A/en
Pending legal-status Critical Current

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  • Quinoline Compounds (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an antibiotic, in high purity and in a short time, by the alkylation of an N-hydroxyquinoline derivative in the presence of a specific compound such as tetraalkyl ammonium halide.
CONSTITUTION: An N-hydroxyquinoline derivative I (R1-3 are H, halogen, nitro, etc.) is made to react with an alkylating agent such as methyl iodide, methyl bromide, etc., in the presence of a quaternary amine base such as tetraalkylammonium halide, etc. or potassium fluoride, and pref. an acid acceptor, at 15W120°C, and the reaction product is hydrolyzed to afford the objective compound II (R is lower alkyl, etc.). The amount of the quaternary amine base or potassium fluoride is ≥1 wt.% based on the compound I.
COPYRIGHT: (C)1979,JPO&Japio
JP1879378A 1978-02-20 1978-02-20 Preparation of 1-substituted-1,4-dihydro-4-oxo-3-quinoline carboxylic acid derivatives Pending JPS54112876A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1879378A JPS54112876A (en) 1978-02-20 1978-02-20 Preparation of 1-substituted-1,4-dihydro-4-oxo-3-quinoline carboxylic acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1879378A JPS54112876A (en) 1978-02-20 1978-02-20 Preparation of 1-substituted-1,4-dihydro-4-oxo-3-quinoline carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
JPS54112876A true JPS54112876A (en) 1979-09-04

Family

ID=11981469

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1879378A Pending JPS54112876A (en) 1978-02-20 1978-02-20 Preparation of 1-substituted-1,4-dihydro-4-oxo-3-quinoline carboxylic acid derivatives

Country Status (1)

Country Link
JP (1) JPS54112876A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861779A (en) * 1985-09-18 1989-08-29 Pfizer Inc. Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861779A (en) * 1985-09-18 1989-08-29 Pfizer Inc. Anti-bacterial substituted bridged-diazabicycloalkyl quinolone carboxylic acids

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