JPS54112892A - Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid - Google Patents

Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid

Info

Publication number: JPS54112892A
Authority: JP; Japan
Prior art keywords: compound; cephem; chloro; carboxylic acid; cephachlor
Prior art date: 1978-02-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP2067578A

Other languages

English (en)

Other versions

JPS611027B2 (ja

Inventor

Yoshinobu Yukioka

Mariko Munekage

Hitoshi Minato

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Shionogi and Co Ltd

Original Assignee

Shionogi and Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-02-23

Filing date

1978-02-23

Publication date

1979-09-04

1978-02-23 Application filed by Shionogi and Co Ltd filed Critical Shionogi and Co Ltd

1978-02-23 Priority to JP2067578A priority Critical patent/JPS54112892A/ja

1979-02-14 Priority to CA000321497A priority patent/CA1137976A/en

1979-02-16 Priority to AU44339/79A priority patent/AU519179B2/en

1979-02-21 Priority to FI790582A priority patent/FI70901C/fi

1979-02-22 Priority to FR7904600A priority patent/FR2418235A1/fr

1979-02-22 Priority to IL56726A priority patent/IL56726A0/xx

1979-02-22 Priority to IT67402/79A priority patent/IT1165634B/it

1979-02-22 Priority to GB7906368A priority patent/GB2016469B/en

1979-02-22 Priority to SE7901601A priority patent/SE445220B/sv

1979-02-22 Priority to DK078779A priority patent/DK157686C/da

1979-02-22 Priority to BE193641A priority patent/BE874377A/xx

1979-02-22 Priority to ES477962A priority patent/ES477962A1/es

1979-02-23 Priority to DE19792907153 priority patent/DE2907153A1/de

1979-02-23 Priority to NL7901453A priority patent/NL7901453A/xx

1979-02-23 Priority to SU792734000A priority patent/SU869560A3/ru

1979-02-23 Priority to AR275610A priority patent/AR223832A1/es

1979-02-23 Priority to CH183279A priority patent/CH644611A5/de

1979-08-08 Priority to IE551/79A priority patent/IE47929B1/en

1979-09-04 Publication of JPS54112892A publication Critical patent/JPS54112892A/ja

1980-05-14 Priority to US06/149,836 priority patent/US4339575A/en

1982-04-13 Priority to US06/367,974 priority patent/US4473567A/en

1986-01-13 Publication of JPS611027B2 publication Critical patent/JPS611027B2/ja

Status Granted legal-status Critical Current

Links

BDZFPCHZINOBKQ-VJSCVCEBSA-N (6R)-3-chloro-4-imidazolidin-1-yl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class N1(CNCC1)C1S[C@H]2N(C(=C1Cl)C(=O)O)C(C2)=O BDZFPCHZINOBKQ-VJSCVCEBSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 2
239000003242 anti bacterial agent Substances 0.000 abstract 2
229940088710 antibiotic agent Drugs 0.000 abstract 2
150000001299 aldehydes Chemical class 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
230000001588 bifunctional effect Effects 0.000 abstract 1
150000001767 cationic compounds Chemical class 0.000 abstract 1
230000032050 esterification Effects 0.000 abstract 1
238000005886 esterification reaction Methods 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
230000007062 hydrolysis Effects 0.000 abstract 1
238000006460 hydrolysis reaction Methods 0.000 abstract 1
229910001411 inorganic cation Inorganic materials 0.000 abstract 1
150000002576 ketones Chemical class 0.000 abstract 1
239000000463 material Substances 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
150000002892 organic cations Chemical class 0.000 abstract 1
239000002994 raw material Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/58—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3 with a nitrogen atom, which is a member of a hetero ring, attached in position 7
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Cephalosporin Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP2067578A 1978-02-23 1978-02-23 Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid Granted JPS54112892A (en)

Priority Applications (20)

Application Number	Priority Date	Filing Date	Title
JP2067578A JPS54112892A (en)	1978-02-23	1978-02-23	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid
CA000321497A CA1137976A (en)	1978-02-23	1979-02-14	Substituted-imidazolidinyl-3-chloro-3- cephem-4-carboxylic acids
AU44339/79A AU519179B2 (en)	1978-02-23	1979-02-16	Substituted-imidazolidinyl-3-chloro-3-cephem-4-carboxylic acids
FI790582A FI70901C (fi)	1978-02-23	1979-02-21	Foerfarande foer framstaellning av 7beta-(5-oxo-4-fenylimidazolidin-1-yl)-3-klor-3-cefem-4-karboxylsyror
ES477962A ES477962A1 (es)	1978-02-23	1979-02-22	Un procedimiento para preparar derivados de acido 3-cloro-3-cefem-4-carboxilico sustituido en 7b con imidazolidinilo.
IL56726A IL56726A0 (en)	1978-02-23	1979-02-22	Substituted imidazolidinyl-3-cephem-4-carboxylic acids,processes for preparing the same and pharmaceutical or veterinary formulations containing the same
IT67402/79A IT1165634B (it)	1978-02-23	1979-02-22	Derivati dell'acido imidazolininil 3 cloro 3 cefem 4 carbossilico e procedimento per la loro preparazione
GB7906368A GB2016469B (en)	1978-02-23	1979-02-22	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acids
SE7901601A SE445220B (sv)	1978-02-23	1979-02-22	Substituerad imidazolidinyl-3-klor-3-cefem-4-karboxylsyra
DK078779A DK157686C (da)	1978-02-23	1979-02-22	Analogifremgangsmaade til fremstilling af 7-beta-substituerede imidazolidinyl-3-chlor-3-cephem-4-carboxylsyrer eller farmaceutisk acceptable salte deraf
BE193641A BE874377A (fr)	1978-02-23	1979-02-22	Acides 7b-(imidazolidinyl substitue)-3-chloro-3-cepheme-4-carboxyliques
FR7904600A FR2418235A1 (fr)	1978-02-23	1979-02-22	Procede de preparation d'acides 7-imidazolidinyl substitue 3-chloro-3-cephem-4-carboxyliques et nouveaux produits ainsi obtenus, employes notamment comme agents antibacteriens
NL7901453A NL7901453A (nl)	1978-02-23	1979-02-23	Gesubstitueerd imidazolidinyl-3-chloor-3-cephem-4-car- bonzuur.
DE19792907153 DE2907153A1 (de)	1978-02-23	1979-02-23	7 beta -(5-oxo-4-phenylimidazolidin- 1-yl)-3-chlor-3-cephem-4-carbonsaeurederivate und verfahren zu ihrer herstellung
SU792734000A SU869560A3 (ru)	1978-02-23	1979-02-23	Способ получени замещенных 7-(5-оксо-4-фенилимидазолидин-1-ил)-3-хлор-3-цефем-4-карбоновых кислот
AR275610A AR223832A1 (es)	1978-02-23	1979-02-23	Procedimiento para preparar acidos 7-beta(5-oxo-4-fenil-imidazolidin-1-il)-3-cloro-3-cefem-4-carboxilicos y sus sales
CH183279A CH644611A5 (de)	1978-02-23	1979-02-23	Substituierte imidazolidinyl-3-chlor-3-cephem-4-carbonsaeuren, verfahren zu ihrer herstellung und pharmazeutische zubereitungen derselben.
IE551/79A IE47929B1 (en)	1978-02-23	1979-08-08	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acids
US06/149,836 US4339575A (en)	1978-02-23	1980-05-14	Substituted-imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid
US06/367,974 US4473567A (en)	1978-02-23	1982-04-13	Substituted-imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2067578A JPS54112892A (en)	1978-02-23	1978-02-23	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid

Publications (2)

Publication Number	Publication Date
JPS54112892A true JPS54112892A (en)	1979-09-04
JPS611027B2 JPS611027B2 (ja)	1986-01-13

Family

ID=12033758

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP2067578A Granted JPS54112892A (en)	1978-02-23	1978-02-23	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid

Country Status (19)

Country	Link
US (2)	US4339575A (ja)
JP (1)	JPS54112892A (ja)
AR (1)	AR223832A1 (ja)
AU (1)	AU519179B2 (ja)
BE (1)	BE874377A (ja)
CA (1)	CA1137976A (ja)
CH (1)	CH644611A5 (ja)
DE (1)	DE2907153A1 (ja)
DK (1)	DK157686C (ja)
ES (1)	ES477962A1 (ja)
FI (1)	FI70901C (ja)
FR (1)	FR2418235A1 (ja)
GB (1)	GB2016469B (ja)
IE (1)	IE47929B1 (ja)
IL (1)	IL56726A0 (ja)
IT (1)	IT1165634B (ja)
NL (1)	NL7901453A (ja)
SE (1)	SE445220B (ja)
SU (1)	SU869560A3 (ja)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS54112892A (en) *	1978-02-23	1979-09-04	Shionogi & Co Ltd	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid
US4727070A (en) *	1985-11-25	1988-02-23	Bristol-Myers Company	3-Propenzl cephalosporin isomer separation process and derivative
US5229509A (en) *	1989-01-10	1993-07-20	Antibioticos, S.A.	Process for the preparation of 3-chloro-cefem compounds

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NL125838C (ja) *	1965-11-24
FR2168924A2 (en) *	1972-01-26	1973-09-07	Bristol Myers Co	Hetacephalexin compsns - for human and veterinary antibacterial therapy, and as foodstuff additive
US3925372A (en) *	1973-02-23	1975-12-09	Lilly Co Eli	Alpha-aminoacyl-3-halo cephalosporins
DE2442539A1 (de) *	1974-09-05	1976-04-01	Squibb & Sons Inc	Cephalosporine und verfahren zu ihrer herstellung
DK154939C (da) *	1974-12-19	1989-06-12	Takeda Chemical Industries Ltd	Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
AU511344B2 (en) *	1975-10-06	1980-08-14	Bristol-Myers Company	"7-(2-substituted-4-(4-hydroxy phenyl) -5 ketoterahydroimidazo-1-yl) - 3- substituted thiomethyl-3-cephem-4-carboxylic acid derivatives
US4091213A (en) *	1975-12-12	1978-05-23	Bristol-Myers Company	7-Cyclizedamino-3-heterothiomethyl cephalosporin derivatives
JPS5289692A (en) *	1976-01-21	1977-07-27	Sankyo Co Ltd	Penicillin and cephalosporin derivatives and preparation thereof
US4042585A (en) *	1976-03-22	1977-08-16	Eli Lilly And Company	Process for preparation of 3-halomethylcephems
US4125716A (en) *	1977-12-16	1978-11-14	Bristol-Myers Company	Methoxymethyl esters of substituted imidazolidinyl-3-methyl-3-cephem-4-carboxylic acids
JPS54112892A (en) *	1978-02-23	1979-09-04	Shionogi & Co Ltd	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid
US4217275A (en) *	1979-02-28	1980-08-12	Bristol-Myers Company	β-Lactam antibiotic esterification process using methoxymethyl methane sulfonate
US4252950A (en) *	1979-10-12	1981-02-24	Eli Lilly And Company	3-Halo cephalosporins

1978
- 1978-02-23 JP JP2067578A patent/JPS54112892A/ja active Granted
1979
- 1979-02-14 CA CA000321497A patent/CA1137976A/en not_active Expired
- 1979-02-16 AU AU44339/79A patent/AU519179B2/en not_active Expired
- 1979-02-21 FI FI790582A patent/FI70901C/fi not_active IP Right Cessation
- 1979-02-22 DK DK078779A patent/DK157686C/da active
- 1979-02-22 FR FR7904600A patent/FR2418235A1/fr active Granted
- 1979-02-22 ES ES477962A patent/ES477962A1/es not_active Expired
- 1979-02-22 GB GB7906368A patent/GB2016469B/en not_active Expired
- 1979-02-22 SE SE7901601A patent/SE445220B/sv unknown
- 1979-02-22 IT IT67402/79A patent/IT1165634B/it active
- 1979-02-22 BE BE193641A patent/BE874377A/xx not_active IP Right Cessation
- 1979-02-22 IL IL56726A patent/IL56726A0/xx not_active IP Right Cessation
- 1979-02-23 DE DE19792907153 patent/DE2907153A1/de not_active Ceased
- 1979-02-23 NL NL7901453A patent/NL7901453A/xx active Search and Examination
- 1979-02-23 SU SU792734000A patent/SU869560A3/ru active
- 1979-02-23 AR AR275610A patent/AR223832A1/es active
- 1979-02-23 CH CH183279A patent/CH644611A5/de not_active IP Right Cessation
- 1979-08-08 IE IE551/79A patent/IE47929B1/en not_active IP Right Cessation
1980
- 1980-05-14 US US06/149,836 patent/US4339575A/en not_active Expired - Lifetime
1982
- 1982-04-13 US US06/367,974 patent/US4473567A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
FI790582A7 (fi)	1979-08-24
SU869560A3 (ru)	1981-09-30
JPS611027B2 (ja)	1986-01-13
US4339575A (en)	1982-07-13
AR223832A1 (es)	1981-09-30
DE2907153A1 (de)	1979-08-30
US4473567A (en)	1984-09-25
FI70901B (fi)	1986-07-18
IT1165634B (it)	1987-04-22
CH644611A5 (de)	1984-08-15
IE47929B1 (en)	1984-07-25
BE874377A (fr)	1979-06-18
CA1137976A (en)	1982-12-21
DK78779A (da)	1979-08-24
ES477962A1 (es)	1979-10-16
IT7967402A0 (it)	1979-02-22
SE7901601L (sv)	1979-08-24
IE790551L (en)	1979-08-23
IL56726A0 (en)	1979-05-31
GB2016469A (en)	1979-09-26
AU4433979A (en)	1979-08-30
DK157686B (da)	1990-02-05
DK157686C (da)	1990-07-16
GB2016469B (en)	1982-08-04
AU519179B2 (en)	1981-11-12
NL7901453A (nl)	1979-08-27
SE445220B (sv)	1986-06-09
FR2418235A1 (fr)	1979-09-21
FI70901C (fi)	1986-10-27
FR2418235B1 (ja)	1982-12-10

Publication	Publication Date	Title
KR830010039A (ko)	1983-12-24	페닐 지방성 카복실린산 유도체의 제조방법
JPS54112892A (en)	1979-09-04	Substituted imidazolidinyl-3-chloro-3-cephem-4-carboxylic acid
JPS5289695A (en)	1977-07-27	Novel 7alpha-methoxycephalosporins and preparation thereof
JPS55139394A (en)	1980-10-31	Novel synthetic method of thiol phosphate ester chloride
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JPS55108898A (en)	1980-08-21	25-hydroxy-24-oxocholesterol derivative and its preparation
JPS56108743A (en)	1981-08-28	3-nitro-2-hydroxy-4-phenylbutyric acid derivative, its ester and preparation thereof
JPS557832A (en)	1980-01-21	Preparation of fibrous zr-containing phosphoric acid compound
JPS5592363A (en)	1980-07-12	New 2-azetidinone derivative
JPS57126427A (en)	1982-08-06	Preparation of 1-substituted-azulene derivative
JPS5679668A (en)	1981-06-30	1,4-dihydro-4-oxonicotinic acid derivatice and its preparation
JPS5419950A (en)	1979-02-15	Synthetic method of methylenebisbenzophenone derivative
JPS5424888A (en)	1979-02-24	Novel 7alpha-methoxycephalosporins and their preparation
JPS57142937A (en)	1982-09-03	Norbornyl-2-aldehyde having unsaturated hydrocarbon side chain and its preparation
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JPS5479247A (en)	1979-06-25	Para-substituted phenylacetic acid derivative and its preparation
JPS5441858A (en)	1979-04-03	6-alkenyl-bicyclo3,1,0hexane-3-ene-2-one derivative and its preparation
JPS5759897A (en)	1982-04-10	Thiazolineazatidinone
JPS5287129A (en)	1977-07-20	4-trifluoromethyl phenoxy phenoxyankane carboxylic acid
JPS54157586A (en)	1979-12-12	Penicillin and cephalosporin
JPS5511501A (en)	1980-01-26	Novel 7-methoxycephalosporin
JPS5758640A (en)	1982-04-08	Hydroxycyclopentenone and its preparation
JPS54148790A (en)	1979-11-21	Ester of pseudomonic acid
JPS54115356A (en)	1979-09-07	1-substituted-5,6,-dithiocalicene derivative and its preparation
JPS5536411A (en)	1980-03-14	Benzylpenicillin derivative and their preparation