JPS54125680A - 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same - Google Patents
5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the sameInfo
- Publication number
- JPS54125680A JPS54125680A JP3296678A JP3296678A JPS54125680A JP S54125680 A JPS54125680 A JP S54125680A JP 3296678 A JP3296678 A JP 3296678A JP 3296678 A JP3296678 A JP 3296678A JP S54125680 A JPS54125680 A JP S54125680A
- Authority
- JP
- Japan
- Prior art keywords
- acid ester
- preparation
- same
- hypotensive agent
- agent containing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 239000002220 antihypertensive agent Substances 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title 1
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002184 metal Substances 0.000 abstract 2
- 239000003960 organic solvent Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 229940081066 picolinic acid Drugs 0.000 abstract 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- LIFCWPVHMDYZHU-UHFFFAOYSA-N 2,3-dihydro-1h-inden-5-yl 5-butoxypyridine-2-carboxylate Chemical compound N1=CC(OCCCC)=CC=C1C(=O)OC1=CC=C(CCC2)C2=C1 LIFCWPVHMDYZHU-UHFFFAOYSA-N 0.000 abstract 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 150000002989 phenols Chemical class 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3296678A JPS54125680A (en) | 1978-03-24 | 1978-03-24 | 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same |
| CA323,912A CA1115709A (fr) | 1978-03-24 | 1979-03-21 | Derives d'acide picolinique hydroxyle, substitue en 5 |
| IT48451/79A IT1115064B (it) | 1978-03-24 | 1979-03-22 | Derivati di acidi picolinici 5-sostituiti procedimento per preparli e composizioni ipertensive che li contengono |
| CH268779A CH637941A5 (fr) | 1978-03-24 | 1979-03-22 | Derives de l'acide picolinique substitues en position 5 et composition anti-hypertensive contenant ces derives. |
| ES478918A ES478918A1 (es) | 1978-03-24 | 1979-03-23 | Un procedimiento para la preparacion de acidos picolinicos 5-sustituidos y sus sales, esteres y amidas. |
| SE7902665A SE446863B (sv) | 1978-03-24 | 1979-03-23 | 5-substituerade pikolinsyraderivat, forfarande for framstellning derav och anvendning av foreningarna som aktiv bestandsdel i en antihypertensiv komposition |
| DE2911492A DE2911492C2 (de) | 1978-03-24 | 1979-03-23 | 5-Substituierte Picolinsäuren, deren Natrium-, Kalium-, Magnesium-, Calcium- und Aluminiumsalze, 5-Indanylester und Säureamide Verfahren zu deren Herstellung und antihypertonische Mittel, welche diese enthalten |
| GB7910324A GB2018753B (en) | 1978-03-24 | 1979-03-23 | 5-substituted picolinic acid derivatives a process for preparation thereof and ananti-hypertensive composition containing the same |
| BE0/194197A BE875070A (fr) | 1978-03-24 | 1979-03-23 | Derives d'acides picoliniques substitues en position 5, procede de preparation de ces derives et composition anti-hypertensive en contenant |
| NLAANVRAGE7902306,A NL178251C (nl) | 1978-03-24 | 1979-03-23 | 5-gesubstitueerde picolinezuren en derivaten daarvan met bloeddruk verlagende werking, werkwijze voor de bereiding daarvan en preparaten die ze bevatten. |
| FR7907345A FR2422639A1 (fr) | 1978-03-24 | 1979-03-23 | Derives d'acide picolinique substitue en 5, procede de preparation et composition anti-hypertensive contenant ces derives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3296678A JPS54125680A (en) | 1978-03-24 | 1978-03-24 | 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS54125680A true JPS54125680A (en) | 1979-09-29 |
Family
ID=12373644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3296678A Pending JPS54125680A (en) | 1978-03-24 | 1978-03-24 | 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS54125680A (fr) |
| BE (1) | BE875070A (fr) |
-
1978
- 1978-03-24 JP JP3296678A patent/JPS54125680A/ja active Pending
-
1979
- 1979-03-23 BE BE0/194197A patent/BE875070A/fr not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE875070A (fr) | 1979-07-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JPS5432460A (en) | Cycloalkylidenemethylphenylacetic acid derivative and their preparation | |
| JPS56115799A (en) | 2'-deoxy-3',5'-di-o-alkylcarbonyl-5-fluorouridine derivative, its preparation, and antitumor agnet containing the same | |
| JPS5549352A (en) | Cyclic iminocarboxylic acid derivative and its salt | |
| JPS57118555A (en) | Leucotriene-analog compound, its preparation, and leucotriene-biosynthesis inhibiting agent containing said compound as active component | |
| JPS54125680A (en) | 5-alkoxypicolinic acid ester, its preparation, and hypotensive agent containing the same | |
| JPS53135958A (en) | Substituted phenylacetic acid derivatives and their preparation | |
| JPS5711981A (en) | Theobromine derivative and its preparation | |
| EP0094612A3 (fr) | Dérivés d'acides alcoyloxazolyl acétiques, procédé de préparation et compositions pharmaceutiques les contenant | |
| JPS5754177A (ja) | Chikanchiazoorujudotai | |
| EP0481891A3 (fr) | Dérivés de l'acide phénoxyacétique, procédé pour leur préparation, et compositions pharmaceutiques les contenant | |
| JPS53119819A (en) | Substituted iso-valerianic acid and its ester | |
| JPS5732260A (en) | Mercaptofatty acid derivative and its preparation | |
| JPS56127378A (en) | 2-alkoxyindolizine derivative and its preparation | |
| JPS5579395A (en) | Novel germanium compound | |
| JPS5466653A (en) | Novel p-aminophenylacetic acid derivative, its preparation, and pharmaceurtical composition containing said derivative as effective component | |
| JPS5439017A (en) | Novel organic sulfonic acid esters and their preparation | |
| JPS5511502A (en) | Preparation of condensed heterocyclic compound | |
| JPS5735596A (en) | Ester derivative of deoxyfluorouridine | |
| JPS5436257A (en) | Substituted benzoic acid amide | |
| JPS5225785A (en) | Preparation of 2-substituted-4- trichloromethyl-6-trifluoromethyl-s- t riazines | |
| JPS52118470A (en) | Dithiolane derivatives | |
| JPS5448770A (en) | 5-alkoxypicolinic acid ester, its preparation and hypotensive agent containing the same | |
| JPS55104266A (en) | Novel pyridone derivative | |
| JPS559039A (en) | Novel propionic acid amide derivative and its preparation | |
| JPS5490158A (en) | Novel benzoylphenoxyacetic acid derivatives |