JPS54148798A - Bridged catharanthus alkaloid dimer - Google Patents

Bridged catharanthus alkaloid dimer

Info

Publication number
JPS54148798A
JPS54148798A JP5962979A JP5962979A JPS54148798A JP S54148798 A JPS54148798 A JP S54148798A JP 5962979 A JP5962979 A JP 5962979A JP 5962979 A JP5962979 A JP 5962979A JP S54148798 A JPS54148798 A JP S54148798A
Authority
JP
Japan
Prior art keywords
bridged
catharanthus alkaloid
alkaloid dimer
dimer
catharanthus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5962979A
Other languages
English (en)
Japanese (ja)
Inventor
Ei Konratsudo Robaato
Gaazon Keeto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of JPS54148798A publication Critical patent/JPS54148798A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP5962979A 1978-05-15 1979-05-14 Bridged catharanthus alkaloid dimer Pending JPS54148798A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/905,667 US4199504A (en) 1978-05-15 1978-05-15 Bridged cathranthus alkaloid dimers

Publications (1)

Publication Number Publication Date
JPS54148798A true JPS54148798A (en) 1979-11-21

Family

ID=25421234

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5962979A Pending JPS54148798A (en) 1978-05-15 1979-05-14 Bridged catharanthus alkaloid dimer

Country Status (21)

Country Link
US (1) US4199504A (de)
EP (3) EP0033981A3 (de)
JP (1) JPS54148798A (de)
AU (1) AU4691379A (de)
BE (1) BE876155A (de)
CA (1) CA1114816A (de)
CS (1) CS214792B2 (de)
DD (3) DD150467A5 (de)
DK (1) DK197579A (de)
ES (3) ES480561A1 (de)
FI (1) FI791519A7 (de)
FR (2) FR2435480A1 (de)
GB (1) GB2022080A (de)
GR (1) GR73047B (de)
IL (1) IL57434A0 (de)
LU (1) LU81254A1 (de)
PH (3) PH14999A (de)
PL (2) PL120896B1 (de)
PT (1) PT69589A (de)
RO (1) RO81682B (de)
ZA (1) ZA792271B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4362664A (en) * 1980-12-29 1982-12-07 Eli Lilly And Company Vinblastine oxazolidinedione disulfides and related compounds
DE3483336D1 (de) * 1983-03-30 1990-11-08 Lilly Industries Ltd Vincaleukoblastin-derivate.
AU5240999A (en) * 1998-07-31 2000-02-21 Goldsmith Seeds Inc. Trimeric and polymeric alkaloids
JP4776843B2 (ja) 1999-10-01 2011-09-21 イムノゲン インコーポレーティッド 免疫複合体及び化学療法剤を用いる癌治療用組成物及び方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR204004A1 (es) * 1973-04-02 1975-11-12 Lilly Co Eli Procedimientos para preparar derivados de vinblastina leurosidina y leurocristina
IL48685A (en) * 1975-01-09 1980-03-31 Lilly Co Eli Amides of vincadioline and vinblastine
GR69783B (de) * 1976-09-08 1982-07-07 Lilly Co Eli
US4115388A (en) * 1977-03-30 1978-09-19 Eli Lilly And Company 3'-Oxygenated derivatives of 4'-deoxy VLB "A" and "B" and related 1-formyl compounds
HU181874B (en) * 1977-08-08 1983-11-28 Lilly Co Eli Process for preparing amides of deacetyl-leurosine and deacetyl-leuroformine

Also Published As

Publication number Publication date
EP0032756A2 (de) 1981-07-29
ES480561A1 (es) 1980-04-01
CS214792B2 (en) 1982-05-28
RO81682A (ro) 1983-04-29
CA1114816A (en) 1981-12-22
PH14999A (en) 1982-03-22
FR2438052A1 (fr) 1980-04-30
GB2022080A (en) 1979-12-12
PL215593A1 (de) 1980-06-16
EP0032756A3 (de) 1981-09-09
EP0033981A2 (de) 1981-08-19
PL120896B1 (en) 1982-03-31
DK197579A (da) 1979-11-16
ES480562A1 (es) 1980-04-01
EP0033981A3 (de) 1981-09-09
PL222094A1 (de) 1980-10-20
PT69589A (en) 1979-06-01
PH14907A (en) 1982-01-29
LU81254A1 (fr) 1979-09-10
BE876155A (fr) 1979-11-12
IL57434A0 (en) 1979-09-30
PH14904A (en) 1982-01-29
EP0005620A1 (de) 1979-11-28
DD147543A5 (de) 1981-04-08
US4199504A (en) 1980-04-22
GR73047B (de) 1984-01-26
DD143618A5 (de) 1980-09-03
FR2435480A1 (fr) 1980-04-04
AU4691379A (en) 1979-11-22
DD150467A5 (de) 1981-09-02
RO81682B (ro) 1983-04-30
ZA792271B (en) 1980-12-31
ES480560A1 (es) 1980-04-01
FI791519A7 (fi) 1981-01-01

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