JPS5490165A - 7-alkylidenebicyclo2.2.1heptene derivbatives - Google Patents
7-alkylidenebicyclo2.2.1heptene derivbativesInfo
- Publication number
- JPS5490165A JPS5490165A JP15658077A JP15658077A JPS5490165A JP S5490165 A JPS5490165 A JP S5490165A JP 15658077 A JP15658077 A JP 15658077A JP 15658077 A JP15658077 A JP 15658077A JP S5490165 A JPS5490165 A JP S5490165A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- cyano
- atom
- attached form
- ethylenedioxyoctylidene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- ZGEGCLOFRBLKSE-UHFFFAOYSA-N 1-Heptene Chemical compound CCCCCC=C ZGEGCLOFRBLKSE-UHFFFAOYSA-N 0.000 title abstract 3
- -1 ethylenedioxy Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 238000006261 Adler reaction Methods 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 210000001772 blood platelet Anatomy 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 230000015271 coagulation Effects 0.000 abstract 1
- 238000005345 coagulation Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000037356 lipid metabolism Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 1
- 150000003180 prostaglandins Chemical class 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:7-Alkylidenebicyclo[2.2.1]heptene derivative of formula I (R is alkyl; A,B are H, OH; or A and B together form ethylenedioxy; or A and B together with the C atom to which they are attached form CO; X, Y are H, halogen, cyano, acetoxy, etc.; or X and Y together with the C atom to which they are attached form CO).
EXAMPLE: 2-Chloro-2-cyano-7-(3,3-ethylenedioxyoctylidene)-bicyclo[2.2.1]hept-5- ene.
USE: An intermediate for the economic synthesis of prostaglandins having activities to the smooth muscle, blood pressure, lipid metabolism, blood platelet coagulation, etc.
PROCESS: The compound IV which is one of the compound I, is prepared by the Diels-Adler reaction of a compound II with a compound III (X', Y' are the groups of X,Y excluding CO, or COOH).
COPYRIGHT: (C)1979,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15658077A JPS5490165A (en) | 1977-12-27 | 1977-12-27 | 7-alkylidenebicyclo2.2.1heptene derivbatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15658077A JPS5490165A (en) | 1977-12-27 | 1977-12-27 | 7-alkylidenebicyclo2.2.1heptene derivbatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5490165A true JPS5490165A (en) | 1979-07-17 |
| JPS6135980B2 JPS6135980B2 (en) | 1986-08-15 |
Family
ID=15630860
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15658077A Granted JPS5490165A (en) | 1977-12-27 | 1977-12-27 | 7-alkylidenebicyclo2.2.1heptene derivbatives |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5490165A (en) |
-
1977
- 1977-12-27 JP JP15658077A patent/JPS5490165A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6135980B2 (en) | 1986-08-15 |
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