JPS5490166A - Preparation of 7-(3-oxo-1-alkenyl)-2-chloro-2-cyanobicyclo 2.2.1hept-5-ene derivatives - Google Patents

Preparation of 7-(3-oxo-1-alkenyl)-2-chloro-2-cyanobicyclo 2.2.1hept-5-ene derivatives

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Publication number
JPS5490166A
JPS5490166A JP15658177A JP15658177A JPS5490166A JP S5490166 A JPS5490166 A JP S5490166A JP 15658177 A JP15658177 A JP 15658177A JP 15658177 A JP15658177 A JP 15658177A JP S5490166 A JPS5490166 A JP S5490166A
Authority
JP
Japan
Prior art keywords
acid
cyanobicyclo
chloro
prostaglandins
treating
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP15658177A
Other languages
Japanese (ja)
Inventor
Tamotsu Fujisawa
Takeo Kobori
Kunikazu Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP15658177A priority Critical patent/JPS5490166A/en
Publication of JPS5490166A publication Critical patent/JPS5490166A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful as an intermediate of prostaglandins having activites to the smooth muscle, blood pressure, lipid metabolism, blood platelet coagulation, etc., by treating the corresponding 7-alkylidene compound under acidic conditions.
CONSTITUTION: The title compound II is prepared by treating 7-alkylidene-2- chloro-2-cyanobicyclo[2.2.1]hept-5-ene derivative of formula I (R is alkyl; A and B together form ethylenedioxy; or together with the C atom to which they are attached form CO) under acidic condition with a mineral acid such as sulfuric acid, hydrochloric acid, phosphoric acid, etc., or an organic sulfonic acid as p-toluene sulfonic acid, benzenesulfonic acid, etc. Since the compound II can be converted to a precursor of 12-epiprostaglandin by reduction, prostaglandins are economically produced therefrom without introducing a side chain.
COPYRIGHT: (C)1979,JPO&Japio
JP15658177A 1977-12-27 1977-12-27 Preparation of 7-(3-oxo-1-alkenyl)-2-chloro-2-cyanobicyclo 2.2.1hept-5-ene derivatives Pending JPS5490166A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP15658177A JPS5490166A (en) 1977-12-27 1977-12-27 Preparation of 7-(3-oxo-1-alkenyl)-2-chloro-2-cyanobicyclo 2.2.1hept-5-ene derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15658177A JPS5490166A (en) 1977-12-27 1977-12-27 Preparation of 7-(3-oxo-1-alkenyl)-2-chloro-2-cyanobicyclo 2.2.1hept-5-ene derivatives

Publications (1)

Publication Number Publication Date
JPS5490166A true JPS5490166A (en) 1979-07-17

Family

ID=15630881

Family Applications (1)

Application Number Title Priority Date Filing Date
JP15658177A Pending JPS5490166A (en) 1977-12-27 1977-12-27 Preparation of 7-(3-oxo-1-alkenyl)-2-chloro-2-cyanobicyclo 2.2.1hept-5-ene derivatives

Country Status (1)

Country Link
JP (1) JPS5490166A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0456852U (en) * 1990-09-25 1992-05-15
JPH04114923U (en) * 1991-03-28 1992-10-12 積水化学工業株式会社 circumference

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0456852U (en) * 1990-09-25 1992-05-15
JPH04114923U (en) * 1991-03-28 1992-10-12 積水化学工業株式会社 circumference

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