JPS5498711A - Novel easily decomposable anti-cholinergic, anti-secretic compound and pharmaceutical composition containing the same - Google Patents
Novel easily decomposable anti-cholinergic, anti-secretic compound and pharmaceutical composition containing the sameInfo
- Publication number
- JPS5498711A JPS5498711A JP15601378A JP15601378A JPS5498711A JP S5498711 A JPS5498711 A JP S5498711A JP 15601378 A JP15601378 A JP 15601378A JP 15601378 A JP15601378 A JP 15601378A JP S5498711 A JPS5498711 A JP S5498711A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- formula
- easily decomposable
- secretic
- cholinergic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000001078 anti-cholinergic effect Effects 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 125000002723 alicyclic group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001262 anti-secretory effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/90—Benzo [c] furans; Hydrogenated benzo [c] furans with an oxygen atom in position 1 and a nitrogen atom in position 3, or vice versa
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyrrole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86121077A | 1977-12-16 | 1977-12-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5498711A true JPS5498711A (en) | 1979-08-03 |
Family
ID=25335183
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15601378A Pending JPS5498711A (en) | 1977-12-16 | 1978-12-15 | Novel easily decomposable anti-cholinergic, anti-secretic compound and pharmaceutical composition containing the same |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5498711A (de) |
| AR (1) | AR222478A1 (de) |
| AT (1) | AT366380B (de) |
| AU (1) | AU531835B2 (de) |
| CA (1) | CA1102345A (de) |
| DE (1) | DE2854308A1 (de) |
| DK (1) | DK534178A (de) |
| ES (1) | ES476048A1 (de) |
| FR (1) | FR2422624A1 (de) |
| GB (1) | GB2010270B (de) |
| IE (1) | IE48012B1 (de) |
| IT (1) | IT1101735B (de) |
| NL (1) | NL7812257A (de) |
| NO (1) | NO148776C (de) |
| SE (1) | SE436027B (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015535849A (ja) * | 2012-10-05 | 2015-12-17 | スファエラ ファーマ ピーティーイー リミテッド | 新規化合物、それらの合成及びそれらの使用 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3045055A1 (de) * | 1980-11-29 | 1982-07-01 | Celamerck Gmbh & Co Kg, 6507 Ingelheim | Heterocyclische verbindungen |
| JPS5993075A (ja) * | 1982-11-18 | 1984-05-29 | Shionogi & Co Ltd | １−フタリジル−５−フルオロウラシル誘導体の製造法 |
| US4824676A (en) * | 1984-10-11 | 1989-04-25 | Schering Corporation | Physiological means of enhancing transdermal delivery of drugs |
| US5008111A (en) * | 1984-10-11 | 1991-04-16 | Schering Corporation | Physiological means of enhancing transdermal delivery of drugs |
| FR2703046B1 (fr) * | 1993-03-26 | 1995-05-05 | Poudres & Explosifs Ste Nale | Procédé de préparation d'oxalates et d'halogénoglyoxalates alpha- monohalogénés et nouveaux oxalates et halogénoglyoxalates alpha-monohalogénés . |
| AUPN814496A0 (en) | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US5962505A (en) * | 1998-08-31 | 1999-10-05 | Bobrove; Arthur M. | Method for treating hot flashes in humans |
| US6433003B1 (en) | 1999-04-23 | 2002-08-13 | Arthur M. Bobrove | Method for treating hyperhidrosis in mammals |
| AR044134A1 (es) * | 2003-05-02 | 2005-08-24 | Novartis Ag | Derivados de quinuclidina, metodo de preparacion y composiciones farmaceuticas. |
| EP1896038B1 (de) | 2005-06-03 | 2016-11-09 | Acrux DDS Pty Ltd | Verfahren und zusammensetzung für die transdermale abgabe von testosteron |
| US20100222393A1 (en) * | 2005-12-30 | 2010-09-02 | Naresh Kumar | Muscarinic receptor antagonists |
| MX2010004788A (es) | 2007-11-02 | 2010-09-14 | Acrux Dds Pty Ltd | Sistema de liberacion transdermica. |
| DE102013013397A1 (de) | 2013-08-13 | 2015-03-12 | Epinamics Gmbh | Aerosolspender für transdermal wirkende pharmazeutische Zusammensetzungen |
| CN110041264A (zh) * | 2019-04-11 | 2019-07-23 | 贺州学院 | 一种金刚烷基咪唑类离子液体及其制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL101555C (de) * | 1955-03-19 | |||
| BE798253A (nl) * | 1973-04-16 | 1973-10-16 | Bekaert Sa Nv | Zitmeubel |
| US3998815A (en) * | 1974-06-24 | 1976-12-21 | Interx Research Corporation | 1-hydrocarbonoyloxymethyl-3-carbamoyl or 3-carboethoxy-pyridinium salts |
-
1978
- 1978-11-29 DK DK534178A patent/DK534178A/da not_active Application Discontinuation
- 1978-12-12 IT IT30735/78A patent/IT1101735B/it active
- 1978-12-15 JP JP15601378A patent/JPS5498711A/ja active Pending
- 1978-12-15 SE SE7812911A patent/SE436027B/sv unknown
- 1978-12-15 NO NO784229A patent/NO148776C/no unknown
- 1978-12-15 AR AR274836A patent/AR222478A1/es active
- 1978-12-15 ES ES476048A patent/ES476048A1/es not_active Expired
- 1978-12-15 DE DE19782854308 patent/DE2854308A1/de not_active Withdrawn
- 1978-12-18 GB GB7848850A patent/GB2010270B/en not_active Expired
- 1978-12-18 NL NL7812257A patent/NL7812257A/xx not_active Application Discontinuation
- 1978-12-18 IE IE2499/78A patent/IE48012B1/en unknown
- 1978-12-18 AU AU42646/78A patent/AU531835B2/en not_active Expired
- 1978-12-18 CA CA318,112A patent/CA1102345A/en not_active Expired
- 1978-12-18 FR FR7835596A patent/FR2422624A1/fr active Granted
- 1978-12-18 AT AT0901478A patent/AT366380B/de active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015535849A (ja) * | 2012-10-05 | 2015-12-17 | スファエラ ファーマ ピーティーイー リミテッド | 新規化合物、それらの合成及びそれらの使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| NO148776C (no) | 1983-12-14 |
| AU531835B2 (en) | 1983-09-08 |
| SE7812911L (sv) | 1979-06-17 |
| IT7830735A0 (it) | 1978-12-12 |
| DK534178A (da) | 1979-06-17 |
| CA1102345A (en) | 1981-06-02 |
| FR2422624B1 (de) | 1983-10-14 |
| ATA901478A (de) | 1981-08-15 |
| SE436027B (sv) | 1984-11-05 |
| IE782499L (en) | 1979-06-16 |
| AT366380B (de) | 1982-04-13 |
| NL7812257A (nl) | 1979-06-19 |
| GB2010270B (en) | 1982-10-20 |
| AU4264678A (en) | 1979-06-21 |
| GB2010270A (en) | 1979-06-27 |
| IE48012B1 (en) | 1984-09-05 |
| ES476048A1 (es) | 1979-11-01 |
| NO148776B (no) | 1983-09-05 |
| IT1101735B (it) | 1985-10-07 |
| NO784229L (no) | 1979-06-19 |
| FR2422624A1 (fr) | 1979-11-09 |
| AR222478A1 (es) | 1981-05-29 |
| DE2854308A1 (de) | 1979-06-21 |
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