JPS55164687A - Novel maytansinoid compound and its preparation - Google Patents

Novel maytansinoid compound and its preparation

Info

Publication number
JPS55164687A
JPS55164687A JP7379079A JP7379079A JPS55164687A JP S55164687 A JPS55164687 A JP S55164687A JP 7379079 A JP7379079 A JP 7379079A JP 7379079 A JP7379079 A JP 7379079A JP S55164687 A JPS55164687 A JP S55164687A
Authority
JP
Japan
Prior art keywords
formula
compound
maytansinol
reaction
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP7379079A
Other languages
English (en)
Inventor
Osamu Miyashita
Hiroshi Akimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Priority to JP7379079A priority Critical patent/JPS55164687A/ja
Priority to US06/092,954 priority patent/US4256746A/en
Priority to US06/153,905 priority patent/US4308268A/en
Priority to AT80103137T priority patent/ATE6158T1/de
Priority to DE8080103137T priority patent/DE3066482D1/de
Priority to EP80103137A priority patent/EP0021177B1/en
Priority to CA000353737A priority patent/CA1135261A/en
Publication of JPS55164687A publication Critical patent/JPS55164687A/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP7379079A 1978-11-14 1979-06-11 Novel maytansinoid compound and its preparation Pending JPS55164687A (en)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP7379079A JPS55164687A (en) 1979-06-11 1979-06-11 Novel maytansinoid compound and its preparation
US06/092,954 US4256746A (en) 1978-11-14 1979-11-09 Dechloromaytansinoids, their pharmaceutical compositions and method of use
US06/153,905 US4308268A (en) 1979-06-11 1980-05-28 Maytansinoids, pharmaceutical compositions thereof and method of use thereof
AT80103137T ATE6158T1 (de) 1979-06-11 1980-06-06 Maytansinoide, ihre herstellung und verwendung.
DE8080103137T DE3066482D1 (en) 1979-06-11 1980-06-06 Maytansinoids, their production and use
EP80103137A EP0021177B1 (en) 1979-06-11 1980-06-06 Maytansinoids, their production and use
CA000353737A CA1135261A (en) 1979-06-11 1980-06-10 Maytansinoids, their production and use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP7379079A JPS55164687A (en) 1979-06-11 1979-06-11 Novel maytansinoid compound and its preparation

Publications (1)

Publication Number Publication Date
JPS55164687A true JPS55164687A (en) 1980-12-22

Family

ID=13528328

Family Applications (1)

Application Number Title Priority Date Filing Date
JP7379079A Pending JPS55164687A (en) 1978-11-14 1979-06-11 Novel maytansinoid compound and its preparation

Country Status (6)

Country Link
US (1) US4308268A (ja)
EP (1) EP0021177B1 (ja)
JP (1) JPS55164687A (ja)
AT (1) ATE6158T1 (ja)
CA (1) CA1135261A (ja)
DE (1) DE3066482D1 (ja)

Families Citing this family (272)

* Cited by examiner, † Cited by third party
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