JPS579784A - Production of penem-3-carboxylic derivative - Google Patents

Production of penem-3-carboxylic derivative

Info

Publication number
JPS579784A
JPS579784A JP8498180A JP8498180A JPS579784A JP S579784 A JPS579784 A JP S579784A JP 8498180 A JP8498180 A JP 8498180A JP 8498180 A JP8498180 A JP 8498180A JP S579784 A JPS579784 A JP S579784A
Authority
JP
Japan
Prior art keywords
compound
phosphorous
formula
penem
triester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP8498180A
Other languages
Japanese (ja)
Other versions
JPH0316357B2 (en
Inventor
Eiji Oki
Sadao Oida
Akira Yoshida
Teruo Hayashi
Shinichi Sugawara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Priority to JP8498180A priority Critical patent/JPS579784A/en
Priority to CH3723/81A priority patent/CH651037A5/en
Priority to NL8102736A priority patent/NL8102736A/en
Priority to FR8111191A priority patent/FR2483924A1/en
Priority to DE19813122523 priority patent/DE3122523A1/en
Priority to US06/271,010 priority patent/US4395418A/en
Priority to ES502828A priority patent/ES502828A0/en
Priority to GB8117447A priority patent/GB2078220B/en
Priority to IT67783/81A priority patent/IT1144602B/en
Publication of JPS579784A publication Critical patent/JPS579784A/en
Publication of JPH0316357B2 publication Critical patent/JPH0316357B2/ja
Granted legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PURPOSE: The reaction of an azetidin-2-one derivative with a phosphorous triester or phosphorous acid triamide affords the titled compound that is important as a synthetic intermediate of penem-3-carboxylic acids, antibiotics.
CONSTITUTION: The reaction between a compound of formula I [R1 is H, alkyl, R4A (R4 is hydroxyl, alkoxy, acyloxy; A is alkylidene that may be substituted with trifluoromethyl); R2 is alkyl, alkenyl, aralkyl; R3 is carboxyl-protecting group; X is O, S; Y is O, S] and a phosphorous triester or phosphorous acid triamide is conducted in a solvent such as methanol or propanol to give the compound of formula II. The phosphorous triester is expressed by (R4)3P (R4 is alkoxy, dialkylamino) and the amount used is 2W20 equivalents per the compound of formula I.
COPYRIGHT: (C)1982,JPO&Japio
JP8498180A 1980-06-06 1980-06-23 Production of penem-3-carboxylic derivative Granted JPS579784A (en)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP8498180A JPS579784A (en) 1980-06-23 1980-06-23 Production of penem-3-carboxylic derivative
CH3723/81A CH651037A5 (en) 1980-06-06 1981-06-05 PENEM-3-CARBONIC ACID DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF.
NL8102736A NL8102736A (en) 1980-06-06 1981-06-05 PENEM-3-CARBONIC ACID COMPOUNDS AND THEIR PREPARATION.
FR8111191A FR2483924A1 (en) 1980-06-06 1981-06-05 PENEME-3-CARBOXYLIC ACID DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND THERAPEUTIC USE THEREOF
DE19813122523 DE3122523A1 (en) 1980-06-06 1981-06-05 PENEM-3-CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THE SAME
US06/271,010 US4395418A (en) 1980-06-06 1981-06-05 Penem-3-carboxylic acid derivatives
ES502828A ES502828A0 (en) 1980-06-06 1981-06-05 A PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF THE ACID PENEN-3-CARBOXILICO.
GB8117447A GB2078220B (en) 1980-06-06 1981-06-08 Penem-3-carboxylic acid derivatives and their preparation
IT67783/81A IT1144602B (en) 1980-06-06 1981-06-08 DERIVATIVES OF PENICIL 3 CARBOXYLIC ACID AND PROCEDURE FOR THEIR PREPARATION

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8498180A JPS579784A (en) 1980-06-23 1980-06-23 Production of penem-3-carboxylic derivative

Publications (2)

Publication Number Publication Date
JPS579784A true JPS579784A (en) 1982-01-19
JPH0316357B2 JPH0316357B2 (en) 1991-03-05

Family

ID=13845783

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8498180A Granted JPS579784A (en) 1980-06-06 1980-06-23 Production of penem-3-carboxylic derivative

Country Status (1)

Country Link
JP (1) JPS579784A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146777A (en) * 1981-02-02 1982-09-10 Schering Plough Corp Manufacture of 2-penem compounds, novel compounds manufactured thereby and pharmaceutic compositions containing them
JPS60188030A (en) * 1984-03-09 1985-09-25 Riichi Nakagawa Preparation of frozen "sushi"
US5856556A (en) * 1982-08-24 1999-01-05 Sankyo Company, Limited Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57146777A (en) * 1981-02-02 1982-09-10 Schering Plough Corp Manufacture of 2-penem compounds, novel compounds manufactured thereby and pharmaceutic compositions containing them
US5856556A (en) * 1982-08-24 1999-01-05 Sankyo Company, Limited Azetidinone derivatives, a process for their preparation and their use as intermediates in the preparation of carbapenem antibiotics
JPS60188030A (en) * 1984-03-09 1985-09-25 Riichi Nakagawa Preparation of frozen "sushi"

Also Published As

Publication number Publication date
JPH0316357B2 (en) 1991-03-05

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