JPS5553264A - 3-(n-substituted carbamoylthio)-2(s)-methylpropionic acid - Google Patents

3-(n-substituted carbamoylthio)-2(s)-methylpropionic acid

Info

Publication number
JPS5553264A
JPS5553264A JP12809578A JP12809578A JPS5553264A JP S5553264 A JPS5553264 A JP S5553264A JP 12809578 A JP12809578 A JP 12809578A JP 12809578 A JP12809578 A JP 12809578A JP S5553264 A JPS5553264 A JP S5553264A
Authority
JP
Japan
Prior art keywords
formula
compound
methylpropionic acid
substituted
carbamoylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP12809578A
Other languages
Japanese (ja)
Inventor
Katsuo Arimura
Takanori Oe
Mineo Tsuruta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Yoshitomi Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yoshitomi Pharmaceutical Industries Ltd filed Critical Yoshitomi Pharmaceutical Industries Ltd
Priority to JP12809578A priority Critical patent/JPS5553264A/en
Publication of JPS5553264A publication Critical patent/JPS5553264A/en
Pending legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:The title compound of formula I (R1, R2=H, alkyl, or aryl, or R1 and R2 may a group which form a heterocyclic ring together with the adjacent N atom; provided that α-carbon is S configuration).
EXAMPLE: 3-(N-ethylcarbamoylthio)-2(S)-methylpropionic acid.
USE: Analgesic and antiphlogistic agent. A synthetic intermediate of hypotensive agents having an excellent inhibitory activity to the angiotensin I converting enzyme.
PROCESS: A compound of formula I is obtained by the reaction of a compound of formula II (Y=halogen) and a compound of formula III, followed by the optical resolution. Moreover, a hypotensive agent of formula V is obtained in high yield by the condensation of the compound of formula I and a compound of formula IV, followed by the removal of N-substituted carbamoyl group.
COPYRIGHT: (C)1980,JPO&Japio
JP12809578A 1978-10-17 1978-10-17 3-(n-substituted carbamoylthio)-2(s)-methylpropionic acid Pending JPS5553264A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP12809578A JPS5553264A (en) 1978-10-17 1978-10-17 3-(n-substituted carbamoylthio)-2(s)-methylpropionic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP12809578A JPS5553264A (en) 1978-10-17 1978-10-17 3-(n-substituted carbamoylthio)-2(s)-methylpropionic acid

Publications (1)

Publication Number Publication Date
JPS5553264A true JPS5553264A (en) 1980-04-18

Family

ID=14976265

Family Applications (1)

Application Number Title Priority Date Filing Date
JP12809578A Pending JPS5553264A (en) 1978-10-17 1978-10-17 3-(n-substituted carbamoylthio)-2(s)-methylpropionic acid

Country Status (1)

Country Link
JP (1) JPS5553264A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787823A (en) * 1985-05-22 1988-11-29 Hultman Barry W Electromagnetic linear motor and pump apparatus

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4787823A (en) * 1985-05-22 1988-11-29 Hultman Barry W Electromagnetic linear motor and pump apparatus

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