JPS5572152A - Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt - Google Patents
Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its saltInfo
- Publication number
- JPS5572152A JPS5572152A JP14495578A JP14495578A JPS5572152A JP S5572152 A JPS5572152 A JP S5572152A JP 14495578 A JP14495578 A JP 14495578A JP 14495578 A JP14495578 A JP 14495578A JP S5572152 A JPS5572152 A JP S5572152A
- Authority
- JP
- Japan
- Prior art keywords
- copper
- copper powder
- alkali metal
- acid
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- 229910052783 alkali metal Inorganic materials 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- -1 alkali metal salt Chemical class 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- JDMFXJULNGEPOI-UHFFFAOYSA-N 2,6-dichloroaniline Chemical class NC1=C(Cl)C=CC=C1Cl JDMFXJULNGEPOI-UHFFFAOYSA-N 0.000 abstract 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- FKLJPTJMIBLJAV-UHFFFAOYSA-N Compound IV Chemical compound O1N=C(C)C=C1CCCCCCCOC1=CC=C(C=2OCCN=2)C=C1 FKLJPTJMIBLJAV-UHFFFAOYSA-N 0.000 abstract 1
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 abstract 1
- 239000005751 Copper oxide Substances 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 229910052802 copper Inorganic materials 0.000 abstract 1
- 239000010949 copper Substances 0.000 abstract 1
- 229910000431 copper oxide Inorganic materials 0.000 abstract 1
- 229910000365 copper sulfate Inorganic materials 0.000 abstract 1
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- CMRLEIHOFQKMCW-UHFFFAOYSA-N n-(2,6-dichlorophenyl)formamide Chemical compound ClC1=CC=CC(Cl)=C1NC=O CMRLEIHOFQKMCW-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003457 sulfones Chemical group 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To prepare the title compound useful as an antiphlogistic and analgesic agent, in high yield, by reacting an alkali metal salt of an ortho-halogenophenylacetic acid with 2,6-dichloroformanilide in the presence of copper powder.
CONSTITUTION: The compound I is prepared by (1) reacting an alkali metal salt of an ortho-halogenophenylacetic acid II (X is halogen; M is alkali metal) with a 2,6-dichloro-aniline derivative III (Y is formyl, sulfone, or OH) in the absence or presence of solvent such as DMF, in the presence of copper (copper powder, reduced copper powder obtained by treating copper sulfate with Zn, or copper powder or copper oxide treated with iodine in acetone), and (2) hydrolyzing the resulting compound IV with an acid.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14495578A JPS5572152A (en) | 1978-11-25 | 1978-11-25 | Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14495578A JPS5572152A (en) | 1978-11-25 | 1978-11-25 | Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5572152A true JPS5572152A (en) | 1980-05-30 |
Family
ID=15374071
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP14495578A Pending JPS5572152A (en) | 1978-11-25 | 1978-11-25 | Preparation of 2-(2,6-dichloroanilino)phenylacetic acid and its salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5572152A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410724A (en) * | 1980-10-20 | 1983-10-18 | Zenyaku Kogyo Kabushiki Kaisha | Process for production of o-(2,6-dichloroanilino)-phenylacetic acid |
-
1978
- 1978-11-25 JP JP14495578A patent/JPS5572152A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4410724A (en) * | 1980-10-20 | 1983-10-18 | Zenyaku Kogyo Kabushiki Kaisha | Process for production of o-(2,6-dichloroanilino)-phenylacetic acid |
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