JPS5581854A - Sulfur-containing compound - Google Patents
Sulfur-containing compoundInfo
- Publication number
- JPS5581854A JPS5581854A JP15516678A JP15516678A JPS5581854A JP S5581854 A JPS5581854 A JP S5581854A JP 15516678 A JP15516678 A JP 15516678A JP 15516678 A JP15516678 A JP 15516678A JP S5581854 A JPS5581854 A JP S5581854A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- carboxylic acid
- group
- diuretic
- carboxyl group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 title 1
- 239000011593 sulfur Substances 0.000 title 1
- 239000002934 diuretic Substances 0.000 abstract 3
- 230000001882 diuretic effect Effects 0.000 abstract 3
- -1 thioester compound Chemical class 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 238000003436 Schotten-Baumann reaction Methods 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 239000002220 antihypertensive agent Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000003396 thiol group Chemical group [H]S* 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:The thioester compound of the carboxyl group of a carboxylic acid-type diuretic and the sulfhydryl group of an N-mercaptoacylamino acid, and its salt.
EXAMPLE: (4R)-3-[(2s)-S-{[2,3-dichloro-4-(2-methylenebutanoyl)-phenoxy] acetyl}-3-mercapto-2-methylpropanoyl]-4-thiazolidine-carboxylic acid.
USE: A long-acting diuretic hypotensive agent having high stability against lowering of the titer and generation of a ill-odor, etc.
PROCESS: A compound I (R4 is a carboxylic acid-type diuretic group wherein the OH of the carboxyl group is removed; Y is OH or halogen; Z is 1W3C alkylene) is subjected to the Schotten-Baumann reaction with a compound II (R1 is H or lower alkyl; R2 is H, phenyl, etc.; R3 is H or CH3) to give a thioester compound.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15516678A JPS5581854A (en) | 1978-12-14 | 1978-12-14 | Sulfur-containing compound |
| US06/086,996 US4483861A (en) | 1978-10-31 | 1979-10-22 | Antihypertensive sulfur-containing compounds |
| GB7936988A GB2038800B (en) | 1978-10-31 | 1979-10-25 | Antihypertensive sulphurcontaining compounds |
| SE7908994A SE448541B (en) | 1978-10-31 | 1979-10-30 | NEW TIAZOLIDINE AND PYRROLIDINE DERIVATIVES AND A PHARMACEUTICAL PREPARATION THEREOF |
| IT26923/79A IT1124841B (en) | 1978-10-31 | 1979-10-30 | COMPOUNDS CONTAINING SULFUR ANTI-HYPERTENSION |
| CH977979A CH642351A5 (en) | 1978-10-31 | 1979-10-31 | Antihypertensive, SULPHUR CONTAINING COMPOUNDS, PROCESS FOR PRODUCING THE SAME AND CONTAINING THEM Pharmaceutical Compositions. |
| DE19792944037 DE2944037A1 (en) | 1978-10-31 | 1979-10-31 | ANTI-HYPERTENSIVE SULFURING COMPOUNDS |
| FR7926983A FR2440365A1 (en) | 1978-10-31 | 1979-10-31 | NOVEL MERCAPTO-AZOLIDINE-CARBOXYLIC ACID DERIVATIVES USEFUL AS HYPERTENSORS |
| US06/395,128 US4496578A (en) | 1978-10-31 | 1982-07-06 | Antihypertensive sulfur-containing compounds |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15516678A JPS5581854A (en) | 1978-12-14 | 1978-12-14 | Sulfur-containing compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5581854A true JPS5581854A (en) | 1980-06-20 |
Family
ID=15599945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15516678A Pending JPS5581854A (en) | 1978-10-31 | 1978-12-14 | Sulfur-containing compound |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5581854A (en) |
-
1978
- 1978-12-14 JP JP15516678A patent/JPS5581854A/en active Pending
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