JPS5583771A - N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt - Google Patents
N-substituted trimethoxybenzylpiperazine derivative and its acid addition saltInfo
- Publication number
- JPS5583771A JPS5583771A JP15829178A JP15829178A JPS5583771A JP S5583771 A JPS5583771 A JP S5583771A JP 15829178 A JP15829178 A JP 15829178A JP 15829178 A JP15829178 A JP 15829178A JP S5583771 A JPS5583771 A JP S5583771A
- Authority
- JP
- Japan
- Prior art keywords
- compound
- addition salt
- acid addition
- trimethazidine
- condensed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 N-substituted trimethoxybenzylpiperazine Chemical class 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- 125000005678 ethenylene group Chemical group [H]C([*:1])=C([H])[*:2] 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000017531 blood circulation Effects 0.000 abstract 1
- 230000002213 calciumantagonistic effect Effects 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 210000004351 coronary vessel Anatomy 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000001965 increasing effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I or its acid addition salt (R1W5 are H, lower alkyl, lower alkoxy, nitro, or halogen; X is ethylene, propylene or ethenylene; when X is ethenylene, at least one of R1W5 is not H).
EXAMPLE: 1-(2,3,4-Trimethoxybenzyl)-4-(4-phenylpropyl)piperazine.
USE: Low-toxic drug having coronary vessel blood flow increasing and calcium antagonistic activity. Stronger activity than trimethazidine.
PROCESS: Trimethazidine is condensed with a carboxylic acid II or its halogenide to afford a compound III, which is reduced or condensed to obtain the compound I. As an alternative method, trimethazidine is condensed with an alcohol IV or its halogenide to obtain the compound I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15829178A JPS5583771A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15829178A JPS5583771A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5583771A true JPS5583771A (en) | 1980-06-24 |
Family
ID=15668385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP15829178A Pending JPS5583771A (en) | 1978-12-20 | 1978-12-20 | N-substituted trimethoxybenzylpiperazine derivative and its acid addition salt |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5583771A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995004050A1 (en) * | 1993-07-28 | 1995-02-09 | Santen Pharmaceutical Co., Ltd. | Novel 1,4-di(phenylalkyl)piperazine derivative |
-
1978
- 1978-12-20 JP JP15829178A patent/JPS5583771A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995004050A1 (en) * | 1993-07-28 | 1995-02-09 | Santen Pharmaceutical Co., Ltd. | Novel 1,4-di(phenylalkyl)piperazine derivative |
| US5736546A (en) * | 1993-07-28 | 1998-04-07 | Santen Pharmaceutical Co., Ltd. | 1,4-(diphenlyalkyl) piperazine derivatives |
| CN1042029C (en) * | 1993-07-28 | 1999-02-10 | 参天制药株式会社 | 1,4-(diphenylalkyl)piperazine derivatives and pharmaceutical compositions containing them |
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