JPS5585539A - Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid - Google Patents
Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acidInfo
- Publication number
- JPS5585539A JPS5585539A JP16171578A JP16171578A JPS5585539A JP S5585539 A JPS5585539 A JP S5585539A JP 16171578 A JP16171578 A JP 16171578A JP 16171578 A JP16171578 A JP 16171578A JP S5585539 A JPS5585539 A JP S5585539A
- Authority
- JP
- Japan
- Prior art keywords
- trans
- cis
- methyl
- species
- caustic alkali
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000926 separation method Methods 0.000 title 1
- 239000003513 alkali Substances 0.000 abstract 3
- 239000003518 caustics Substances 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: To separate a cis-and trans-1-methyl-4-isohexylcyclohexanecarboxylic acid ester mixture into its constitutents, in simple reaction processes, by hudrolyzing the mixture stepwise using a caustic alkali.
CONSTITUTION: A mixture of cis- and trans-1-methyl-4-isohexylcyclohexanecarboxylic acid esters is hydrolyzed in a water-containing alcohol at 30W40°C for 7W12 hours using a caustic alkali in an amount equimolar to the trans-ester, whereby the trans species of the carboxylic acid is separated selectively. Subsequently, unreacted cis species is refluxed under heating at 60W120°C for 5W8 hours in a water-containing alcohol, using a small excess mole of a caustic alkali, whereby cis species of the carboxylic acid is separated.
EFFECT: The desired compounds are obtained in high purity and yield at low costs.
USE: Medicines.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16171578A JPS5585539A (en) | 1978-12-22 | 1978-12-22 | Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP16171578A JPS5585539A (en) | 1978-12-22 | 1978-12-22 | Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5585539A true JPS5585539A (en) | 1980-06-27 |
Family
ID=15740493
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP16171578A Pending JPS5585539A (en) | 1978-12-22 | 1978-12-22 | Separation of cis- and trans-1-methyl-4-isohexyl- cyclohexanecarboxylic acid |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5585539A (en) |
-
1978
- 1978-12-22 JP JP16171578A patent/JPS5585539A/en active Pending
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