JPS5587773A - Production of cimetidine, antagonist to histamine h2 receptor - Google Patents

Production of cimetidine, antagonist to histamine h2 receptor

Info

Publication number: JPS5587773A
Authority: JP; Japan
Prior art keywords: compound; formula; alkyl; histamine; antagonist
Prior art date: 1978-12-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

JP15989578A

Other languages

English (en)

Other versions

JPS5914460B2 (ja

Inventor

Saburo Uchikuga

Tomoyasu Tashiro

Yasuko Osawa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sogo Pharmaceutical Co Ltd

Original Assignee

Sogo Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1978-12-27

Filing date

1978-12-27

Publication date

1980-07-02

1978-12-27 Application filed by Sogo Pharmaceutical Co Ltd filed Critical Sogo Pharmaceutical Co Ltd

1978-12-27 Priority to JP53159895A priority Critical patent/JPS5914460B2/ja

1979-05-04 Priority to GB7915698A priority patent/GB2038313B/en

1979-05-09 Priority to IT48981/79A priority patent/IT1162314B/it

1979-05-11 Priority to DE19792919131 priority patent/DE2919131A1/de

1979-05-18 Priority to FR7912697A priority patent/FR2445322A1/fr

1979-05-21 Priority to CH473079A priority patent/CH637943A5/fr

1979-08-08 Priority to IE1406/79A priority patent/IE48532B1/en

1980-01-17 Priority to US06/113,135 priority patent/US4413129A/en

1980-07-02 Publication of JPS5587773A publication Critical patent/JPS5587773A/ja

1984-04-04 Publication of JPS5914460B2 publication Critical patent/JPS5914460B2/ja

Status Expired legal-status Critical Current

Links

239000005557 antagonist Substances 0.000 title abstract 2
CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 title abstract 2
229960001380 cimetidine Drugs 0.000 title abstract 2
102000003710 Histamine H2 Receptors Human genes 0.000 title 1
108090000050 Histamine H2 Receptors Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 6
BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 4
NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 2
JEOZNMMOIBLWLV-UHFFFAOYSA-N 2-[(5-methyl-1h-imidazol-4-yl)methylsulfanyl]ethanamine Chemical compound CC=1N=CNC=1CSCCN JEOZNMMOIBLWLV-UHFFFAOYSA-N 0.000 abstract 1
QMVCRMKELLPOMY-UHFFFAOYSA-N 2-aminoethanethiol;sulfuric acid Chemical compound NCCS.OS(O)(=O)=O QMVCRMKELLPOMY-UHFFFAOYSA-N 0.000 abstract 1
LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000002622 anti-tumorigenesis Effects 0.000 abstract 1
239000006227 byproduct Substances 0.000 abstract 1
239000007795 chemical reaction product Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000012458 free base Substances 0.000 abstract 1
229960001340 histamine Drugs 0.000 abstract 1
229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
239000011707 mineral Substances 0.000 abstract 1
239000002994 raw material Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

JP53159895A 1978-12-27 1978-12-27 Ｈ↓２受容体「きつ」抗剤シメチジンの製造法 Expired JPS5914460B2 (ja)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
JP53159895A JPS5914460B2 (ja)	1978-12-27	1978-12-27	Ｈ↓２受容体「きつ」抗剤シメチジンの製造法
GB7915698A GB2038313B (en)	1978-12-27	1979-05-04	Process for preparing h-receptor antagonist cimetidine
IT48981/79A IT1162314B (it)	1978-12-27	1979-05-09	Procedimento per preparare cimetidina
DE19792919131 DE2919131A1 (de)	1978-12-27	1979-05-11	Verfahren zur herstellung des h tief 2 -rezeptor-antagonisten cimetidin
FR7912697A FR2445322A1 (fr)	1978-12-27	1979-05-18	Preparation de la cimetidine
CH473079A CH637943A5 (fr)	1978-12-27	1979-05-21	Procede de fabrication de la cimetidine.
IE1406/79A IE48532B1 (en)	1978-12-27	1979-08-08	Process for preparing h2-receptor antagonist cimetidine
US06/113,135 US4413129A (en)	1978-12-27	1980-01-17	Process for preparing the H2 -receptor antagonist cimetidine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP53159895A JPS5914460B2 (ja)	1978-12-27	1978-12-27	Ｈ↓２受容体「きつ」抗剤シメチジンの製造法

Publications (2)

Publication Number	Publication Date
JPS5587773A true JPS5587773A (en)	1980-07-02
JPS5914460B2 JPS5914460B2 (ja)	1984-04-04

Family

ID=15703511

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP53159895A Expired JPS5914460B2 (ja)	1978-12-27	1978-12-27	Ｈ↓２受容体「きつ」抗剤シメチジンの製造法

Country Status (8)

Country	Link
US (1)	US4413129A (ja)
JP (1)	JPS5914460B2 (ja)
CH (1)	CH637943A5 (ja)
DE (1)	DE2919131A1 (ja)
FR (1)	FR2445322A1 (ja)
GB (1)	GB2038313B (ja)
IE (1)	IE48532B1 (ja)
IT (1)	IT1162314B (ja)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4528378A (en) *	1982-03-29	1985-07-09	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4528377A (en) *	1982-03-29	1985-07-09	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4528375A (en) *	1982-03-29	1985-07-09	Bristol-Myers Company	Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
EP0224612A1 (de) *	1985-12-05	1987-06-10	HEUMANN PHARMA GMBH & CO	Verfahren zur Herstellung von N-Cyano-N'-methyl-N"[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidin
JPH01238574A (ja) *	1988-03-17	1989-09-22	Mitsui Toatsu Chem Inc	グアニジン誘導体の製造法
JPH01272570A (ja) *	1988-04-26	1989-10-31	Nippon Shokubai Kagaku Kogyo Co Ltd	４−メチル−５−［（２−アミノエチル）−チオメチル］−イミダゾールの製法
ES2009921A6 (es) *	1988-05-26	1989-10-16	Vinas Lab	Procedimiento para la obtencion de derivados imidazolicos.
US6353005B1 (en)	1999-03-02	2002-03-05	Sepracor, Inc.	Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6362202B1 (en)	1999-03-02	2002-03-26	Sepracor Inc.	Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US7157017B2 (en)	2003-11-26	2007-01-02	Buckman Laboratories International, Inc.	Fungicidal compositions and methods using cyanodithiocarbimates
CN104557720B (zh) *	2015-01-21	2017-03-15	盐城凯利药业有限公司	一种西咪替丁的制备方法
CN111320584A (zh) *	2020-03-30	2020-06-23	石家庄市普力制药有限公司	一种生产西咪替丁二缩物的生产方法
CN115960048B (zh) *	2021-10-09	2025-01-24	常州安迪沃克医药科技有限公司	一种甲氰咪胍的制备方法
CN114149348A (zh) *	2021-12-15	2022-03-08	河北新石制药有限公司	西咪替丁缩合杂质的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4048319A (en) *	1969-10-29	1977-09-13	Smith Kline & French Laboratories Limited	Method of inhibiting histamine activity with quanidine compounds
GB1338169A (en) *	1971-03-09	1973-11-21	Smith Kline French Lab	Ureas thioureas and guanidines
GB1397436A (en) *	1972-09-05	1975-06-11	Smith Kline French Lab	Heterocyclic n-cyanoguinidines
US3979398A (en) *	1973-02-08	1976-09-07	Smith Kline & French Laboratories Limited	Sulphoxides
GB1565647A (en) *	1975-07-31	1980-04-23	Smith Kline French Lab	Pharmacologically active compounds 4-substituted-imidazole-5-methanols
PT65369B (en) *	1975-08-20	1978-01-10	Smithkline Corp	Reduction process

1978
- 1978-12-27 JP JP53159895A patent/JPS5914460B2/ja not_active Expired
1979
- 1979-05-04 GB GB7915698A patent/GB2038313B/en not_active Expired
- 1979-05-09 IT IT48981/79A patent/IT1162314B/it active
- 1979-05-11 DE DE19792919131 patent/DE2919131A1/de not_active Withdrawn
- 1979-05-18 FR FR7912697A patent/FR2445322A1/fr active Granted
- 1979-05-21 CH CH473079A patent/CH637943A5/fr not_active IP Right Cessation
- 1979-08-08 IE IE1406/79A patent/IE48532B1/en unknown
1980
- 1980-01-17 US US06/113,135 patent/US4413129A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IE791406L (en)	1980-06-27
US4413129A (en)	1983-11-01
CH637943A5 (fr)	1983-08-31
GB2038313A (en)	1980-07-23
GB2038313B (en)	1983-01-19
IT1162314B (it)	1987-03-25
JPS5914460B2 (ja)	1984-04-04
DE2919131A1 (de)	1980-07-17
FR2445322B1 (ja)	1983-02-11
IT7948981A0 (it)	1979-05-09
FR2445322A1 (fr)	1980-07-25
IE48532B1 (en)	1985-02-20

Publication	Publication Date	Title
JPS5587773A (en)	1980-07-02	Production of cimetidine, antagonist to histamine h2 receptor
GB1397436A (en)	1975-06-11	Heterocyclic n-cyanoguinidines
ES8707733A1 (es)	1987-08-16	Un procedimiento para la preparacion de triazolobenzodiazepinas
IE39607L (en)	1975-01-13	Diheterocyclic ureas, thioureas, and guanidines
GB1131191A (en)	1968-10-23	New imidazole derivatives, their preparation and use
CH615916A5 (ja)	1980-02-29
GB1398426A (en)	1975-06-18	Heterocyclic substituted guanidines
GB1077076A (en)	1967-07-26	Novel imidazole derivatives and a process for the manufacture thereof
HU911277D0 (en)	1991-10-28	Process for producing sulfonyl-amino-substitued bicyclic hydroxam acid derivatives
ZA822759B (en)	1983-04-27	Manufacture of quaternary ammonium compounds
US4157340A (en)	1979-06-05	N,N'-[Bis(N-cyanoguanyl)]cystamine derivatives
BG100366A (en)	1996-07-31	Method for the preparation of substitued 4,6-diamino-5-cyanopyrimidines
EP0080739A3 (en)	1983-08-24	Process for preparing cimetidine
MY103208A (en)	1993-05-29	Cyanoguanidine derivative and process for preparation thereof
DE2964430D1 (en)	1983-02-03	Process for preparing symmetric 1,3-disubstituted ureas
GB1570213A (en)	1980-06-25	Imidazoles
US3923826A (en)	1975-12-02	Synthesis of 5-(beta-methylmercaptoethyl)-hydantoin
MY103207A (en)	1993-05-29	Cyanoguanidine derivative and process for preparation thereof
JPS56142269A (en)	1981-11-06	Novel imidazole compound and its preparation
IE44397B1 (en)	1981-11-18	Imidazoles
EP0269315A3 (en)	1988-07-06	Amine production
JPS55118476A (en)	1980-09-11	Novel amidine derivative and its preparation
US4322539A (en)	1982-03-30	Conversion of ethers to thioamines
JPS5663945A (en)	1981-05-30	Preparation of novel alkanolamine derivative
JPS5716892A (en)	1982-01-28	Synthesis of n-trialkylsilylmethylurea