JPS559024A - Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituent - Google Patents
Tetrahydro ml-236b, its derivative, and remedy for hyperlipemia comprising it as active constituentInfo
- Publication number
- JPS559024A JPS559024A JP8128678A JP8128678A JPS559024A JP S559024 A JPS559024 A JP S559024A JP 8128678 A JP8128678 A JP 8128678A JP 8128678 A JP8128678 A JP 8128678A JP S559024 A JPS559024 A JP S559024A
- Authority
- JP
- Japan
- Prior art keywords
- tetrahydro
- formula
- hyperlipemia
- remedy
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 201000005577 familial hyperlipidemia Diseases 0.000 title abstract 2
- 239000000470 constituent Substances 0.000 title 1
- AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract 5
- 229910052751 metal Inorganic materials 0.000 abstract 4
- 239000002184 metal Substances 0.000 abstract 4
- 125000005907 alkyl ester group Chemical group 0.000 abstract 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000003054 catalyst Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- -1 ML-236B carboxylic acid Chemical class 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:Tetrahydro ML-236B of formula I, a metal salt of the carboxylic acid of formula II: (M is metal element; n is the valence of the element), or an alkyl ester of formula III: (R is alkyl group).
USE: Remedies for hyperlipemia.
PROCESS: ML-236B is dissolved in tetrahydrofuran, and hydrogenated in the presence of a catalyst to give a tetrahydro ML-236B of formula I. An alkyl ester of ML-236B is dissolved in an alcohol and catalytically reduced in the presence of a catalyst to give an alkyl ester of ML-236B of formula III. The ester is converted into an alkali (earth) metal, or aluminum salt to give a metal salt of the tetrahydro ML-236B carboxylic acid of formula II.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8128678A JPS6026094B2 (en) | 1978-07-04 | 1978-07-04 | Tetrahydro ML↓-236B and its derivatives, and a therapeutic agent for hyperlipidemia containing the same as an active ingredient |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8128678A JPS6026094B2 (en) | 1978-07-04 | 1978-07-04 | Tetrahydro ML↓-236B and its derivatives, and a therapeutic agent for hyperlipidemia containing the same as an active ingredient |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS559024A true JPS559024A (en) | 1980-01-22 |
| JPS6026094B2 JPS6026094B2 (en) | 1985-06-21 |
Family
ID=13742124
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8128678A Expired JPS6026094B2 (en) | 1978-07-04 | 1978-07-04 | Tetrahydro ML↓-236B and its derivatives, and a therapeutic agent for hyperlipidemia containing the same as an active ingredient |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS6026094B2 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0033538A2 (en) | 1980-02-04 | 1981-08-12 | Merck & Co. Inc. | 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same |
| JPS56122374A (en) * | 1980-02-04 | 1981-09-25 | Merck & Co Inc | Hypocholesterolemic hydrogenation product and its manufacture |
| JPS57149247A (en) * | 1981-03-11 | 1982-09-14 | Sankyo Co Ltd | Trans tetrahydro ml-236b and its derivative |
| JPS58210043A (en) * | 1982-05-31 | 1983-12-07 | メルク エンド カムパニー インコーポレーテツド | 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)- 2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)- decahydronaphthyl-1(s))ethyl)- 4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one |
| US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4450171A (en) * | 1980-08-05 | 1984-05-22 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| JPS59122483A (en) * | 1982-12-28 | 1984-07-14 | Nippon Chemiphar Co Ltd | Novel monacolin derivative, its preparation and remedy for hyperlipemia containing the same |
| JPS6037043U (en) * | 1983-08-17 | 1985-03-14 | 松本 昌芳 | key point tape |
-
1978
- 1978-07-04 JP JP8128678A patent/JPS6026094B2/en not_active Expired
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0033538A2 (en) | 1980-02-04 | 1981-08-12 | Merck & Co. Inc. | 6(R)-(2-(8'-acyloxy-2'-methyl-6'-methyl (or hydrogen)-polyhydronaphthyl-1')-ethyl)-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones, the hydroxy acid form of said pyranones, the pharmaceutically acceptable salts of said hydroxy acids, and the lower alkyl, and phenyl, dimethylamino or acetylamino substituted lower alkyl esters of said hydroxy acid, processes for preparing the same, and a pharmaceutical antihypercholesterolemic composition containing the same |
| JPS56122374A (en) * | 1980-02-04 | 1981-09-25 | Merck & Co Inc | Hypocholesterolemic hydrogenation product and its manufacture |
| US4444784A (en) * | 1980-08-05 | 1984-04-24 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| US4450171A (en) * | 1980-08-05 | 1984-05-22 | Merck & Co., Inc. | Antihypercholesterolemic compounds |
| JPS57149247A (en) * | 1981-03-11 | 1982-09-14 | Sankyo Co Ltd | Trans tetrahydro ml-236b and its derivative |
| JPS58210043A (en) * | 1982-05-31 | 1983-12-07 | メルク エンド カムパニー インコーポレーテツド | 6(r)-(2-(8(s)(2,2-dimethylbutyryloxy)- 2(s),6(s)-dimethyl-1,2,3,4,4a(s),5,6,7,8,8a(s)- decahydronaphthyl-1(s))ethyl)- 4(r)-hydroxy-3,4,5,6-tetrahydro-2h-pyran-2-one |
| JPS59122483A (en) * | 1982-12-28 | 1984-07-14 | Nippon Chemiphar Co Ltd | Novel monacolin derivative, its preparation and remedy for hyperlipemia containing the same |
| JPS6037043U (en) * | 1983-08-17 | 1985-03-14 | 松本 昌芳 | key point tape |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6026094B2 (en) | 1985-06-21 |
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