JPS5798232A - 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal - Google Patents

1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal

Info

Publication number
JPS5798232A
JPS5798232A JP55157049A JP15704980A JPS5798232A JP S5798232 A JPS5798232 A JP S5798232A JP 55157049 A JP55157049 A JP 55157049A JP 15704980 A JP15704980 A JP 15704980A JP S5798232 A JPS5798232 A JP S5798232A
Authority
JP
Japan
Prior art keywords
compound expressed
naphthyl
methoxy
formula
acetal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP55157049A
Other languages
Japanese (ja)
Inventor
Genichi Dobashi
Shuichi Mitamura
Atsuji Kitajima
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP55157049A priority Critical patent/JPS5798232A/en
Priority to NZ198271A priority patent/NZ198271A/en
Priority to IE393/88A priority patent/IE53540B1/en
Priority to IE2057/81A priority patent/IE53333B1/en
Priority to PT73624A priority patent/PT73624B/en
Priority to GR65980A priority patent/GR75077B/el
Priority to DK396581A priority patent/DK161020C/en
Priority to YU2161/81A priority patent/YU43500B/en
Priority to AR286701A priority patent/AR228067A1/en
Priority to EP84113585A priority patent/EP0151702B1/en
Priority to ES505375A priority patent/ES505375A0/en
Priority to AT81304154T priority patent/ATE20338T1/en
Priority to IN1023/CAL/81A priority patent/IN155107B/en
Priority to IL74744A priority patent/IL74744A/en
Priority to PH26181A priority patent/PH17798A/en
Priority to NO813088A priority patent/NO157616C/en
Priority to AT84113585T priority patent/ATE31056T1/en
Priority to DE8181304154T priority patent/DE3174810D1/en
Priority to EP81304154A priority patent/EP0048136B1/en
Priority to IL63791A priority patent/IL63791A0/en
Priority to FI812820A priority patent/FI73195C/en
Priority to DE8484113585T priority patent/DE3176543D1/en
Priority to RO110734A priority patent/RO86227B/en
Priority to RO110733A priority patent/RO85818B/en
Priority to KR1019810003384A priority patent/KR860000173B1/en
Priority to CA000385670A priority patent/CA1186318A/en
Priority to RO81105287A priority patent/RO82085A/en
Priority to DD81256548A priority patent/DD216007A5/en
Priority to PL1981232991A priority patent/PL133927B1/en
Priority to DD81233229A priority patent/DD202866A5/en
Priority to NO820123A priority patent/NO158015C/en
Priority to ES509056A priority patent/ES8302641A1/en
Publication of JPS5798232A publication Critical patent/JPS5798232A/en
Priority to CS828708A priority patent/CS255854B2/en
Priority to PH29246A priority patent/PH21751A/en
Priority to PH29248A priority patent/PH21746A/en
Priority to PH29247A priority patent/PH20879A/en
Priority to CA000454627A priority patent/CA1186319A/en
Priority to IN568/MAS/84A priority patent/IN160124B/en
Priority to IN569/MAS/84A priority patent/IN160312B/en
Priority to IL74744A priority patent/IL74744A0/en
Priority to AU45889/85A priority patent/AU599006B2/en
Priority to KR1019850007244A priority patent/KR860002164B1/en
Priority to KR1019850007245A priority patent/KR870000133B1/en
Priority to FI862106A priority patent/FI75336C/en
Priority to YU2288/86A priority patent/YU45076B/en
Priority to NO871680A priority patent/NO166708C/en
Priority to SG981/87A priority patent/SG98187G/en
Priority to MY825/87A priority patent/MY8700825A/en
Priority to HK205/89A priority patent/HK20589A/en
Priority to DK055790A priority patent/DK163056C/en
Priority to DK055690A priority patent/DK163179C/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:A compound expressed by formulaI[R1, R2 and R3 are lower alkyl or R1 and R2 together may form a cyclic acetal; Y is H or RSO2- (R is aromatic group or alkyl which may have a substituent group)].
EXAMPLE: 1-(6-Methoxy-2-naphthyl)-2-hydroxy-1-propanone dimethyl acetal.
USE: An intermediate capable of preparing an α-(6-methoxy-2-naphthyl)alkanoic acid or an ester thereof useful as an anti-inflammatory and an analgesic agent by an easy operation easily in high yield.
PROCESS: A compound expressed by formula III (X is halogen) is reacted with a compound expressed by the formula R1OM (M is alkali metal) in the presence of a compound expressed by the formula R1OH to give a compound expressed by formulaIa (R1 is R2). The resultant compound is then reacted with an O-sulfonylating agent to afford the aimed compound expressed by formulaIb, which is then hydrolyzed to give the compound expressed by formula II (R4 is H or lower alkyl) with ease.
COPYRIGHT: (C)1982,JPO&Japio
JP55157049A 1980-09-11 1980-11-10 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal Pending JPS5798232A (en)

Priority Applications (51)

Application Number Priority Date Filing Date Title
JP55157049A JPS5798232A (en) 1980-11-10 1980-11-10 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal
NZ198271A NZ198271A (en) 1980-09-11 1981-09-04 Preparation of alpha-aromatic-substituted alkanoic acids and intermediates
IE393/88A IE53540B1 (en) 1980-09-11 1981-09-04 Alpha-hydroxyketone acetals
IE2057/81A IE53333B1 (en) 1980-09-11 1981-09-04 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
PT73624A PT73624B (en) 1980-09-11 1981-09-07 PROCESS FOR PREPARING ALPHA-AROMATIC GROUP SUBSTITUTED ALKANOIC ACIDS OR ESTERS THEREOF
GR65980A GR75077B (en) 1980-09-11 1981-09-08
DK396581A DK161020C (en) 1980-09-11 1981-09-08 PROCEDURE FOR THE PREPARATION OF AN AROMATIC GROUP OF ALFA-SUBSTITUTED ALCANCARBOXYLIC ACIDS OR ESTERS THEREOF, AND CONNECTIONS FOR USING THE PROCEDURE
YU2161/81A YU43500B (en) 1980-09-11 1981-09-09 Process for obtaining alcanoic acids with a substituted alpha-aromatic group or esters thereof
AR286701A AR228067A1 (en) 1980-09-11 1981-09-09 A PROCEDURE TO PREPARE SUBSTITUTED ALKANOIC ACID WITH AN ALPHA-AROMATIC GROUP, OR ITS ESTER
EP84113585A EP0151702B1 (en) 1980-09-11 1981-09-10 Alpha-hydroxyketone acetals
ES505375A ES505375A0 (en) 1980-09-11 1981-09-10 A PROCEDURE FOR PREPARING A SUBSTITUTED ALKANOIC ACID WITH AN AROMATIC GROUP IN ALPHA POSITION.
AT81304154T ATE20338T1 (en) 1980-09-11 1981-09-10 PROCESS FOR THE PREPARATION OF ALKYLIC ACIDS OR THEIR ESTERS ALPHA-SUBSTITUTED BY AN AROMATIC GROUP.
IN1023/CAL/81A IN155107B (en) 1980-09-11 1981-09-10
IL74744A IL74744A (en) 1980-09-11 1981-09-10 1-aryl-2-hydroxy acetals
PH26181A PH17798A (en) 1980-09-11 1981-09-10 Process for preparation of alpha-aromatic group substituted alkanoic acid or esters thereof
NO813088A NO157616C (en) 1980-09-11 1981-09-10 METHOD OF PREPARING ONE WITH AN AROMATIC GROUP OF A-SUBSTITUTED ALKANIC ACID, AND ESTERS THEREOF.
AT84113585T ATE31056T1 (en) 1980-09-11 1981-09-10 ACETALS OF ALPHA-HYDROXYKETONES.
DE8181304154T DE3174810D1 (en) 1980-09-11 1981-09-10 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
EP81304154A EP0048136B1 (en) 1980-09-11 1981-09-10 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
IL63791A IL63791A0 (en) 1980-09-11 1981-09-10 Preparation of alpha-aryl-alkanoic acids and esters thereof
FI812820A FI73195C (en) 1980-09-11 1981-09-10 FOERFARANDE FOER FRAMSTAELLNING AV ALKANSYROR, VILKA I -STAELLNING AER SUBSTITUERADE MED EN AROMATISK GRUPP, OCH ESTRAR DAERAV, NYA MELLANPRODUKTER OCH DERAS FRAMSTAELLNING.
DE8484113585T DE3176543D1 (en) 1980-09-11 1981-09-10 Alpha-hydroxyketone acetals
RO110734A RO86227B (en) 1980-09-11 1981-09-11 Process for preparing some substituted alpha-sulphonyloxyphenone acetals
RO110733A RO85818B (en) 1980-09-11 1981-09-11 Process for preparing aromatically alpha-substituted alkanoic acids and esters thereof
KR1019810003384A KR860000173B1 (en) 1980-09-11 1981-09-11 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
CA000385670A CA1186318A (en) 1980-09-11 1981-09-11 PROCESS FOR PREPARATION OF .alpha.-AROMATIC GROUP SUBSTITUTED ALKANOIC ACID OR ESTERS THEREOF
RO81105287A RO82085A (en) 1980-09-11 1981-09-11 PROCESS FOR THE PREPARATION OF ALKANOIC ACIDS WITH AN ALPHA AROMATIC OR ESTERIC SUBSTITUENT
DD81256548A DD216007A5 (en) 1980-09-11 1981-09-11 PROCESS FOR PREPARING ALPHA SULPHONYLOXYKETONE ACETALES
PL1981232991A PL133927B1 (en) 1980-09-11 1981-09-11 Process for preparing alkanocarboxylic acids substituted in position alpha with aromatic group or their esters
DD81233229A DD202866A5 (en) 1980-09-11 1981-09-11 METHOD FOR PRODUCING ALPHA-SUBSTITUTED ALKANSAEURES
NO820123A NO158015C (en) 1980-09-11 1982-01-15 CONNECTION FOR USE IN THE PREPARATION OF ALFA-SUBSTITUTED ALKANIC ACIDS OR ESTERS.
ES509056A ES8302641A1 (en) 1980-09-11 1982-01-26 A procedure for preparing an acetal of an alpha-sulfonyl-oxycetone. (Machine-translation by Google Translate, not legally binding)
CS828708A CS255854B2 (en) 1980-09-11 1982-12-02 A method for producing α-sulfonyloxycetone acetals
PH29246A PH21751A (en) 1980-09-11 1983-07-18 Intermediates used in the process for the preparation of alpha-sulfonyloxyketone acetal
PH29248A PH21746A (en) 1980-09-11 1983-07-18 Process for the preparation of alpha-sulfonyloxy-ketone acetal
PH29247A PH20879A (en) 1980-09-11 1983-07-18 Process for the preparation of alpha-aromatic group substituted alkanoic acid or esters thereof
CA000454627A CA1186319A (en) 1980-09-11 1984-05-17 Alphasulfonyloxyketone acetals
IN568/MAS/84A IN160124B (en) 1980-09-11 1984-08-04
IN569/MAS/84A IN160312B (en) 1980-09-11 1984-08-04
IL74744A IL74744A0 (en) 1980-09-11 1985-03-28 1-aryl-2-hydroxy acetals
AU45889/85A AU599006B2 (en) 1980-09-11 1985-08-07 Alpha-hydroxy dialkyl acetals
KR1019850007244A KR860002164B1 (en) 1980-09-11 1985-09-30 Preparation of α-aromatic group substituted alkanoic acid and esters thereof
KR1019850007245A KR870000133B1 (en) 1980-09-11 1985-09-30 Method for preparing α-sulfonyloxyketone acetal
FI862106A FI75336C (en) 1980-09-11 1986-05-20 Use of alpha-hydroxy ketone acetals.
YU2288/86A YU45076B (en) 1980-09-11 1986-12-31 Process for obtaining new alphasulphonyloxiketone-acethale
NO871680A NO166708C (en) 1980-09-11 1987-04-22 INTERMEDIATES FOR THE PREPARATION OF ALKANIC ACIDS AND ESTERS THEREOF.
SG981/87A SG98187G (en) 1980-09-11 1987-11-04 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
MY825/87A MY8700825A (en) 1980-09-11 1987-12-30 Process for preparing alpha-aromatic group substituted alkanoic acids or estersthereof
HK205/89A HK20589A (en) 1980-09-11 1989-03-09 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof
DK055790A DK163056C (en) 1980-09-11 1990-03-02 ANALOGY PROCEDURE FOR THE PREPARATION OF ALFA SULPHONYLOXYKETON ACETALS
DK055690A DK163179C (en) 1980-09-11 1990-03-02 ALFA-HYDROXYKETONE ACETALS

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55157049A JPS5798232A (en) 1980-11-10 1980-11-10 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal

Publications (1)

Publication Number Publication Date
JPS5798232A true JPS5798232A (en) 1982-06-18

Family

ID=15641071

Family Applications (1)

Application Number Title Priority Date Filing Date
JP55157049A Pending JPS5798232A (en) 1980-09-11 1980-11-10 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal

Country Status (1)

Country Link
JP (1) JPS5798232A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192325A (en) * 1981-04-30 1982-11-26 Syntex Pharma Int Manufacture of alpha-arylalkanoic acids and precurcors therefor
JPS6341439A (en) * 1986-08-01 1988-02-22 ザンボン・エス．ピ−．エイ． Synthesis of carboxylic acid
JPH02262532A (en) * 1981-12-11 1990-10-25 Syntex Pharmceut Internatl Ltd Optically active ketal
JP2020517590A (en) * 2017-04-24 2020-06-18 アイジーエム グループ ビー．ヴィ． A convenient oxidative functionalization of alkyl aryl ketones.

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57192325A (en) * 1981-04-30 1982-11-26 Syntex Pharma Int Manufacture of alpha-arylalkanoic acids and precurcors therefor
JPH02262532A (en) * 1981-12-11 1990-10-25 Syntex Pharmceut Internatl Ltd Optically active ketal
JPS6341439A (en) * 1986-08-01 1988-02-22 ザンボン・エス．ピ−．エイ． Synthesis of carboxylic acid
JP2020517590A (en) * 2017-04-24 2020-06-18 アイジーエム グループ ビー．ヴィ． A convenient oxidative functionalization of alkyl aryl ketones.
US11203580B2 (en) 2017-04-24 2021-12-21 Igm Group B.V. Simple oxidative functionalized of alkyl aryl ketones

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