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Taisho Pharmaceutical Co Ltd
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Taisho Pharmaceutical Co Ltd
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Application filed by Taisho Pharmaceutical Co LtdfiledCriticalTaisho Pharmaceutical Co Ltd
Priority to JP8270878ApriorityCriticalpatent/JPS559053A/en
Publication of JPS559053ApublicationCriticalpatent/JPS559053A/en
PURPOSE: To obtain an antibiotic preparation for rectal infusion, having improved dispersibility and absorbability through the rectum, by dispersing a specific novel penicilline derivative in the presence of a nonionic surfactant.
CONSTITUTION: A suppository, soft capsule, liquid, etc., prepared by dispersing D-α-(4-hydroxy-pirazino[2,3-f]quinoline-3-carboxyamide)-benzylpenicillin alkali metal salt (novel compound) of the formula in a mixture of a nonionic surfactant and a base. The compound of the formula is an antibiotic substance having brood antibiotic spectrum against Gram-positive and Gram-negative bacteria, and has only poor absorbability through the digestive tract by oral administration.
COPYRIGHT: (C)1980,JPO&Japio
JP8270878A1978-07-071978-07-07Preparation for rectal infusion
PendingJPS559053A
(en)
6-AMINO-7-HYDROXY-4,5,6,7-TETRAHYDROIMIDAZO(4,5 1-J,K)(1)BENZAZEPINE-2(1H)-ONEDERIVATE, THEIR SALTS, THEIR PRODUCTION, THEIR USE AS MEDICINES AND PREPARATIONS THIS CONTAINS.