JPS56102794A - Preparation of pyrimidine ribonucleosides and pyrimidine deoxyribonucleosides - Google Patents
Preparation of pyrimidine ribonucleosides and pyrimidine deoxyribonucleosidesInfo
- Publication number
- JPS56102794A JPS56102794A JP5371879A JP5371879A JPS56102794A JP S56102794 A JPS56102794 A JP S56102794A JP 5371879 A JP5371879 A JP 5371879A JP 5371879 A JP5371879 A JP 5371879A JP S56102794 A JPS56102794 A JP S56102794A
- Authority
- JP
- Japan
- Prior art keywords
- pyrimidine
- imparter
- deoxyribose
- ribose
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title abstract 5
- 239000005549 deoxyribonucleoside Substances 0.000 title abstract 2
- 239000002342 ribonucleoside Substances 0.000 title abstract 2
- ASJSAQIRZKANQN-CRCLSJGQSA-N 2-deoxy-D-ribose Chemical compound OC[C@@H](O)[C@@H](O)CC=O ASJSAQIRZKANQN-CRCLSJGQSA-N 0.000 abstract 3
- HMFHBZSHGGEWLO-SOOFDHNKSA-N D-ribofuranose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-SOOFDHNKSA-N 0.000 abstract 3
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 abstract 3
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 abstract 3
- 241000894006 Bacteria Species 0.000 abstract 2
- HMFHBZSHGGEWLO-TXICZTDVSA-N beta-D-ribose Chemical group OC[C@H]1O[C@@H](O)[C@H](O)[C@@H]1O HMFHBZSHGGEWLO-TXICZTDVSA-N 0.000 abstract 2
- 241000588722 Escherichia Species 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical compound O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 150000001875 compounds Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 230000007704 transition Effects 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
PURPOSE: To prepare pyrimidine ribonucleosides or pyrimidine deoxyribonucleosides, by the transition of sugar part from a ribose imparter or deoxyribose imparter using a bacterium.
CONSTITUTION: A ribose imparter or deoxyribose imparter is reacted with a pyrimidine base shown by the formula I (X is OH or NH2; Y is H, NO2, halogen, alkoxy, or CF2; Z is H or COOH) in the presence of a bacterium belonging to the genus Escherichia, having an ability to transfer β-D-ribofuranosyl group of the ribose imparter or β-D-deoxyribofuranosyl group of the deoxyribose imparter to the first position of the compound shown by the formula I in an aqueous solution at 50W 65°C, to give a nucleoside shown by the formula II (X, Y, and Z are the same as those shown ealier; R is β-D-ribofuranosyl group or β-D-deoxyribofuranosyl group).
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5371879A JPS56102794A (en) | 1979-05-01 | 1979-05-01 | Preparation of pyrimidine ribonucleosides and pyrimidine deoxyribonucleosides |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5371879A JPS56102794A (en) | 1979-05-01 | 1979-05-01 | Preparation of pyrimidine ribonucleosides and pyrimidine deoxyribonucleosides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS56102794A true JPS56102794A (en) | 1981-08-17 |
Family
ID=12950600
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP5371879A Pending JPS56102794A (en) | 1979-05-01 | 1979-05-01 | Preparation of pyrimidine ribonucleosides and pyrimidine deoxyribonucleosides |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56102794A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6460396A (en) * | 1987-08-28 | 1989-03-07 | Ajinomoto Kk | Production of 2'-deoxycytidine |
| JPS6474998A (en) * | 1987-09-17 | 1989-03-20 | Ajinomoto Kk | Production of uridine |
| JPH01104190A (en) * | 1987-07-17 | 1989-04-21 | Ajinomoto Co Inc | Production of thymidine |
| US4835104A (en) * | 1987-06-16 | 1989-05-30 | Ajinomoto Co., Inc., Patent & Licensing Department | Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides |
| JPH01320995A (en) * | 1988-06-22 | 1989-12-27 | Japan Tobacco Inc | Production of nucleoside compound |
| JPH0223882A (en) * | 1988-07-12 | 1990-01-26 | Ajinomoto Co Inc | Production of 5-methyluridine |
| WO2007060886A1 (en) * | 2005-11-24 | 2007-05-31 | National University Corporation Hokkaido University | Therapeutic agent for neurodegenerative disease |
-
1979
- 1979-05-01 JP JP5371879A patent/JPS56102794A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4835104A (en) * | 1987-06-16 | 1989-05-30 | Ajinomoto Co., Inc., Patent & Licensing Department | Process for producing and purifying 2',3'-dideoxynucleosides, and process for producing 2',3'-dideoxy-2',3'-didehydronucleosides |
| JPH01104190A (en) * | 1987-07-17 | 1989-04-21 | Ajinomoto Co Inc | Production of thymidine |
| JPS6460396A (en) * | 1987-08-28 | 1989-03-07 | Ajinomoto Kk | Production of 2'-deoxycytidine |
| JPS6474998A (en) * | 1987-09-17 | 1989-03-20 | Ajinomoto Kk | Production of uridine |
| JPH01320995A (en) * | 1988-06-22 | 1989-12-27 | Japan Tobacco Inc | Production of nucleoside compound |
| JPH0223882A (en) * | 1988-07-12 | 1990-01-26 | Ajinomoto Co Inc | Production of 5-methyluridine |
| WO2007060886A1 (en) * | 2005-11-24 | 2007-05-31 | National University Corporation Hokkaido University | Therapeutic agent for neurodegenerative disease |
| US8318798B2 (en) | 2005-11-24 | 2012-11-27 | National University Corporation Hokkaldo University | Therapeutic agent for neurodegenerative disease |
| JP5145563B2 (en) * | 2005-11-24 | 2013-02-20 | 国立大学法人北海道大学 | Drugs for neurodegenerative diseases |
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