JPS5612352A - Ai-77, medically permissible salt thereof and their preparation - Google Patents
Ai-77, medically permissible salt thereof and their preparationInfo
- Publication number
- JPS5612352A JPS5612352A JP8689279A JP8689279A JPS5612352A JP S5612352 A JPS5612352 A JP S5612352A JP 8689279 A JP8689279 A JP 8689279A JP 8689279 A JP8689279 A JP 8689279A JP S5612352 A JPS5612352 A JP S5612352A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- preparation
- eluted
- adsorbed
- combines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 title abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000002596 lactones Chemical group 0.000 abstract 2
- 239000011347 resin Substances 0.000 abstract 2
- 229920005989 resin Polymers 0.000 abstract 2
- 241000194103 Bacillus pumilus Species 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 150000001338 aliphatic hydrocarbons Chemical class 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 230000002402 anti-lipaemic effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 239000001963 growth medium Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002609 medium Substances 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Furan Compounds (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:AI-77 of formula I [X is NR6 where R6 is H, R (R is 1W17C aliphatic hydrocarbon or 6W10C aromatic hydrocarbon), O; Y is NHR5 or combines with Z to form linkage; Z is H and other groups; R1, R3 and R5 are H, -CH2R, -COR; R2 is H or combine with T1 to form a linkage connecting with C and O in the lactone ring; T1 is hydroxyl; R4 combines with T2 to form linkage connecting with C and O in the lactone ring; T2 is hydroxyl].
EXAMPLE: The compound of formula II.
USE: Antiulcerative, anti-inflammatory, antilipemic, antiarrhythmic, vasodilator, or their intermediate.
PREPARATION: Bacillus pumilus AI-77 (FERM-4066) is aerobically cultured in a medium containing nitrogen and carbon sources, inorganic salts and so on at 25W 40°C and the resultant filtrate of the culture medium is adsorbed on a weak-acid cation resin. Then, it is eluted with a dilute acid and adsorbed on a macro-network resin. Finally, it is eluted with water or an organic solvent to give purified AI-77 of formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8689279A JPS5612352A (en) | 1979-07-11 | 1979-07-11 | Ai-77, medically permissible salt thereof and their preparation |
| GB8022059A GB2058047B (en) | 1979-07-11 | 1980-07-04 | Amides and amidines |
| FR8015179A FR2476085B1 (en) | 1979-07-11 | 1980-07-08 | COMPOUNDS OBTAINED BY CULTURE OF MICROORGANISMS BELONGING TO THE BACILLUS STRAIN AND METHOD FOR OBTAINING THEM |
| IT49209/80A IT1195309B (en) | 1979-07-11 | 1980-07-10 | AI-77 COMPOUNDS THEIR PHARMACEUTICALLY ACCEPTABLE SALTS AND PROCEDURE TO PRODUCE THEM |
| DE19803026214 DE3026214A1 (en) | 1979-07-11 | 1980-07-10 | SALICYL ACID DERIVATIVES, YOUR PHARMACEUTICALLY COMPATIBLE SALT AND METHOD FOR THE PRODUCTION THEREOF |
| NLAANVRAGE8003985,A NL187069C (en) | 1979-07-11 | 1980-07-10 | N-ACYL 3- (1-AMINO-3-METHYLBUTYL) -8-HYDROXY-3,4-DIHYDRO-ISOCOUMARINE COMPOUND, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL PREPARATION. |
| CH5281/80A CH654005A5 (en) | 1979-07-11 | 1980-07-10 | 3,4-DIHYDRO-8-HYDROXYISOCOUMARINS AND THEIR SALTS ACCEPTABLE IN PHARMACY. |
| US06/167,581 US4393225A (en) | 1979-07-11 | 1980-07-11 | AI-77 Compounds and pharmaceutically acceptable salts thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8689279A JPS5612352A (en) | 1979-07-11 | 1979-07-11 | Ai-77, medically permissible salt thereof and their preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5612352A true JPS5612352A (en) | 1981-02-06 |
| JPS6334863B2 JPS6334863B2 (en) | 1988-07-12 |
Family
ID=13899482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8689279A Granted JPS5612352A (en) | 1979-07-11 | 1979-07-11 | Ai-77, medically permissible salt thereof and their preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5612352A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643531A (en) * | 1989-12-12 | 1997-07-01 | Samsung Heavy Industry Co., Ltd. | Ferrous alloy composition and manufacture and coating methods of mechanical products using the same |
| JP2007509043A (en) * | 2003-10-07 | 2007-04-12 | レノビス， インコーポレイテッド | Amide derivatives and pharmaceutical compositions as ion channel ligands and methods of using them |
| JP2007291004A (en) * | 2006-04-25 | 2007-11-08 | Kotobuki Seiyaku Kk | Azulene derivatives and serum cholesterol lowering agents containing the same |
| WO2009022399A1 (en) * | 2007-08-10 | 2009-02-19 | Yoshichika Kameyama | Novel microorganism having gastric juice promoting action and composition secreted by the same |
-
1979
- 1979-07-11 JP JP8689279A patent/JPS5612352A/en active Granted
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5643531A (en) * | 1989-12-12 | 1997-07-01 | Samsung Heavy Industry Co., Ltd. | Ferrous alloy composition and manufacture and coating methods of mechanical products using the same |
| JP2007509043A (en) * | 2003-10-07 | 2007-04-12 | レノビス， インコーポレイテッド | Amide derivatives and pharmaceutical compositions as ion channel ligands and methods of using them |
| JP2007291004A (en) * | 2006-04-25 | 2007-11-08 | Kotobuki Seiyaku Kk | Azulene derivatives and serum cholesterol lowering agents containing the same |
| WO2009022399A1 (en) * | 2007-08-10 | 2009-02-19 | Yoshichika Kameyama | Novel microorganism having gastric juice promoting action and composition secreted by the same |
| JPWO2009022399A1 (en) * | 2007-08-10 | 2010-11-11 | 佳務 亀山 | Novel microorganism having gastric juice promoting action and secreted composition thereof |
| JP4695191B2 (en) * | 2007-08-10 | 2011-06-08 | 佳務 亀山 | Novel microorganism having gastric juice promoting action and secreted composition thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6334863B2 (en) | 1988-07-12 |
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