JPS5612376A - Novel thiazolidone derivative, its preparation, and drug for ulcer having antidigestive action - Google Patents
Novel thiazolidone derivative, its preparation, and drug for ulcer having antidigestive actionInfo
- Publication number
- JPS5612376A JPS5612376A JP8705679A JP8705679A JPS5612376A JP S5612376 A JPS5612376 A JP S5612376A JP 8705679 A JP8705679 A JP 8705679A JP 8705679 A JP8705679 A JP 8705679A JP S5612376 A JPS5612376 A JP S5612376A
- Authority
- JP
- Japan
- Prior art keywords
- action
- ulcer
- drug
- antidigestive
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- 208000025865 Ulcer Diseases 0.000 title abstract 2
- 231100000397 ulcer Toxicity 0.000 title abstract 2
- SLYRGJDSFOCAAI-UHFFFAOYSA-N 1,3-thiazolidin-2-one Chemical class O=C1NCCS1 SLYRGJDSFOCAAI-UHFFFAOYSA-N 0.000 title 1
- OPHQOIGEOHXOGX-UHFFFAOYSA-N 3,4,5-trimethoxybenzaldehyde Chemical compound COC1=CC(C=O)=CC(OC)=C1OC OPHQOIGEOHXOGX-UHFFFAOYSA-N 0.000 abstract 2
- 230000005764 inhibitory process Effects 0.000 abstract 2
- FGAWSQOQZQIHPF-UHFFFAOYSA-N 2-(3,4,5-trimethoxyphenyl)-4H-1,3-thiazol-4-ide 1-oxide Chemical compound COC=1C=C(C=C(C=1OC)OC)C=1S(C=[C-]N=1)=O FGAWSQOQZQIHPF-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 210000005036 nerve Anatomy 0.000 abstract 1
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 abstract 1
- 239000003204 tranquilizing agent Substances 0.000 abstract 1
Landscapes
- Thiazole And Isothizaole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A 2-(3,4,5-trimethoxyphenyl)-4-thiazolidone shown by the formula I.
USE: A drug for ulcer having antidigestive action and low toxcity. Useful for remedying gastric ulcer and duodenal ulcer. Having mild blood pressure lowering action and nerve center redative action and no undesirable central inhibition, e.g., motor nerve inhibition, the drug can be useful as a hypotensive or tranquillizer.
PROCESS: For example, 3,4,5-trimethoxybenzaldehyde shown by the formula II is reacted with thioglycollic acid amide to give a compound shown by the formula I.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (10)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8705679A JPS5612376A (en) | 1979-07-09 | 1979-07-09 | Novel thiazolidone derivative, its preparation, and drug for ulcer having antidigestive action |
| CA000355457A CA1154447A (en) | 1979-07-09 | 1980-07-04 | 2-substituted-4-thiazolidones |
| GB8022293A GB2055816B (en) | 1979-07-09 | 1980-07-08 | Thiazolidones |
| IT23314/80A IT1131681B (en) | 1979-07-09 | 1980-07-08 | 4-THIAZOLIDONES 2-USEFUL SUBSTITUTES AS DRUGS AND PROCEDURE FOR THEIR PREPARATION |
| FR8015205A FR2468598B1 (en) | 1979-07-09 | 1980-07-08 | THIAZOLIDONES-4 SUBSTITUTED IN 2, THEIR PREPARATION PROCESS AND THE MEDICINES CONTAINING THEM |
| DE3026053A DE3026053C2 (en) | 1979-07-09 | 1980-07-09 | 2-substituted-4-thiazolidones |
| ES493649A ES8105308A1 (en) | 1979-07-09 | 1980-07-09 | 2-Substituted-4-thiazolidones |
| ES500075A ES8202545A1 (en) | 1979-07-09 | 1981-02-13 | 2-Substituted-4-thiazolidones |
| US06/412,964 US4540702A (en) | 1979-07-09 | 1982-08-30 | 2-Substituted-4-thiazolidones |
| US06/708,556 US4722932A (en) | 1979-07-09 | 1985-08-30 | 2-substituted-4-thiazolidones |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP8705679A JPS5612376A (en) | 1979-07-09 | 1979-07-09 | Novel thiazolidone derivative, its preparation, and drug for ulcer having antidigestive action |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS5612376A true JPS5612376A (en) | 1981-02-06 |
| JPS6310700B2 JPS6310700B2 (en) | 1988-03-08 |
Family
ID=13904276
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8705679A Granted JPS5612376A (en) | 1979-07-09 | 1979-07-09 | Novel thiazolidone derivative, its preparation, and drug for ulcer having antidigestive action |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5612376A (en) |
-
1979
- 1979-07-09 JP JP8705679A patent/JPS5612376A/en active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6310700B2 (en) | 1988-03-08 |
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